@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu29750: (2016-07-18 )
MSNTELELLRQKADELNLQILKLINERGNVVKEIGKAKEAQGVNRFDPVRERTMLNNIIENNDGPFENSTIQHIFKEIFKAGLELQEEDHSKALLVSRKKKPEDTIVDIKGEKIGDGQQRFIVGPCAVESYEQVAEVAAAAKKQGIKILRGGAFKPRTSPYDFQGLGVEGLQILKRVADEFDLAVISEIVTPAHIEEALDYIDVIQIGARNMQNFELLKAAGAVKKPVLLKRGLAATISEFINAAEYIMSQGNDQIILCERGIRTYETATRNTLDISAVPILKQETHLPVFVDVTHSTGRRDLLLPTAKAALAIGADGVMAEVHPDPSVALSDSAQQMAIPEFEKWLNELKPMVKVNA
Atome Classification :
(56 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.-----......150....--...160.......-170.......180.......190.......200.......210.......220.......230.......240.......250.......260.--....-..270..--.....280.......290......-----------.300.......310.......320.......330-........340.......350.-----.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
N
T
E
L
E
L
L
R
Q
K
A
D
E
L
N
L
Q
I
L
K
L
I
N
ER
G
N
V
V
K
E
I
G
K
A
K
EAQGVNRFD
P
V
R
E
R
T
M
L
N
N
I
I
ENNDGPFEN
S
T
I
Q
H
I
F
K
E
I
F
K
AGLELQEEDHS
K
A
L
L
V
SRKKKPED
T
I
V
D
I
KGEKIGDGQ
Q
R
F
I
VG
P
C
A
V
E
S
Y
E
Q
V
A
E
V
A
A
A
A
K
K-----Q
G
I
K
I
LRGGAFKP--RTSPYDFQGLG
V
E
-
G
L
Q
I
L
K
R
V
A
D
EF
D
L
A
V
I
S
E
IV
T
P
A
H
I
E
E
A
L
D
Y
I
D
V
I
Q
IGARNM
Q
N
F
E
L
L
K
AAGAVKK
P
V
L
L
K
R
G
L
A
A
T
I
S
E
F
I
N
A
A
E
Y
I
M
SQGN
D
Q
I
I
L
CERGI--R
T
Y
E-TATRN
T
L
--DISAVPILKQETHL
P
V
F
V
D
V
THST-----------GRR
D
L
L
LPTA
K
A
A
L
A
IGAD
G
V
M
A
EVHPDPSVAL--SDS
A
Q
QMA
I
P
E
F
E
K
W
L
N
EL
K
P
M
-----VKVNA
1
PsiBlast_PDB
94.64
76%
-98
- C2 -
3NVT
2
?
A:
[32-374]
-------
E
L
R
T
Q
V
D
Q
L
N
I
D
L
L
E
L
I
S
K
R
A
N
L
V
Q
E
I
G
K
I
K
G
-----
R
F
D
P
L
R
E
R
E
M
L
N
T
I
L
A
A
N
E
G
P
F
E
D
S
T
V
Q
K
L
F
K
E
I
F
K
A
G
L
E
L
Q
E
E
D
H
S
K
A
L
L
V
S
R
K
N
K
K
E
D
T
I
V
T
V
K
G
L
P
I
G
N
G
E
P
V
F
V
F
G
P
C
S
V
E
S
Y
E
Q
V
A
A
V
A
E
S
I
K
A
-----
K
G
L
K
L
I
R
G
G
A
F
K
P
--
R
T
S
P
Y
D
F
Q
G
L
G
L
E
-
G
L
K
I
L
K
R
V
S
D
E
Y
G
L
G
V
I
S
E
I
V
T
P
A
D
I
E
V
A
L
D
Y
V
D
V
I
Q
I
G
A
R
N
M
Q
N
F
E
L
L
K
A
A
G
R
V
D
K
P
I
L
L
K
R
G
L
S
A
T
I
E
E
F
I
G
A
A
E
Y
I
M
S
Q
G
N
G
K
I
I
L
C
E
R
G
I
--
R
T
Y
E
-
K
A
T
R
N
T
L
--
D
I
S
A
V
P
I
L
K
K
E
T
H
L
P
V
M
V
D
V
T
H
S
T
-----------
G
R
K
D
L
L
L
P
C
A
K
A
A
L
A
I
E
A
D
G
V
M
A
E
V
H
P
D
P
A
V
A
L
--
S
D
S
A
Q
Q
M
D
I
P
E
F
E
E
F
W
N
A
I
-------------
2
PsiBlast_PDB
94.62
76%
-103
- C2 -
3TFC
3
?
A:
[33-374]
--------
L
R
T
Q
V
D
Q
L
N
I
D
L
L
E
L
I
S
K
R
A
N
L
V
Q
E
I
G
K
I
K
-----
L
R
F
D
P
L
R
E
R
E
M
L
N
T
I
L
A
A
N
E
G
P
F
E
D
S
T
V
Q
K
L
F
K
E
I
F
K
A
G
L
E
L
Q
E
E
D
H
S
K
A
L
L
V
S
R
K
N
K
K
E
D
T
I
V
T
V
K
G
L
P
I
G
N
G
E
P
V
F
V
F
G
P
C
S
V
E
S
Y
E
Q
V
A
A
V
A
E
S
I
K
A
-----
K
G
L
K
L
I
R
G
G
A
F
K
P
--
R
T
S
P
Y
D
F
Q
G
L
G
L
E
-
G
L
K
I
L
K
R
V
S
D
E
Y
G
L
G
V
I
S
E
I
V
T
P
A
D
I
E
V
A
L
D
Y
V
D
V
I
Q
I
G
A
R
N
M
Q
N
F
E
L
L
K
A
A
G
R
V
D
K
P
I
L
L
K
R
G
L
S
A
T
I
E
E
F
I
G
A
A
E
Y
I
M
S
Q
G
N
G
K
I
I
L
C
E
R
G
I
--
R
T
Y
E
-
K
A
T
R
N
T
L
--
D
I
S
A
V
P
I
L
K
K
E
T
H
L
P
V
M
V
D
V
T
H
S
T
-----------
G
R
K
D
L
L
L
P
C
A
K
A
A
L
A
I
E
A
D
G
V
M
A
E
V
H
P
D
P
A
V
A
L
--
S
D
S
A
Q
Q
M
D
I
P
E
F
E
E
F
W
N
A
I
-------------
124
Fugue
94.47
75%
-98
- C2 -
3NVT
2
?
A:
[32-381]
-------
E
L
R
T
Q
V
D
Q
L
N
I
D
L
L
E
L
I
S
K
R
A
N
L
V
Q
E
I
G
K
I
K
-----
G
R
F
D
P
L
R
E
R
E
M
L
N
T
I
L
A
A
N
E
G
P
F
E
D
S
T
V
Q
K
L
F
K
E
I
F
K
A
G
L
E
L
Q
E
E
D
H
S
K
A
L
L
V
S
R
K
N
K
K
E
D
T
I
V
T
V
K
G
L
P
I
G
N
G
E
P
V
F
V
F
G
P
C
S
V
E
S
Y
E
Q
V
A
A
V
A
E
S
I
K
A
-----
K
G
L
K
L
I
R
G
G
A
F
K
P
--
R
T
S
P
Y
D
F
Q
G
L
G
L
E
-
G
L
K
I
L
K
R
V
S
D
E
Y
G
L
G
V
I
S
E
I
V
T
P
A
D
I
E
V
A
L
D
Y
V
D
V
I
Q
I
G
A
R
N
M
Q
N
F
E
L
L
K
A
A
G
R
V
D
K
P
I
L
L
K
R
G
L
S
A
T
I
E
E
F
I
G
A
A
E
Y
I
M
S
Q
G
N
G
K
I
I
L
C
E
R
G
I
--
R
T
Y
E
-
K
A
T
R
N
T
L
--
D
I
S
A
V
P
I
L
K
K
E
T
H
L
P
V
M
V
D
V
T
H
S
T
-----------
G
R
K
D
L
L
L
P
C
A
K
A
A
L
A
I
E
A
D
G
V
M
A
E
V
H
P
D
P
A
V
A
L
--
S
D
S
A
Q
Q
M
D
I
P
E
F
E
E
F
W
N
A
I
L
A
S
-----
N
L
V
P
-
21
PsiBlast_CBE
94.23
76%
-107
- C2 -
3TFC
3
?
B:
[29-374]
----
N
L
E
E
L
R
T
Q
V
D
Q
L
N
I
D
L
L
E
L
I
S
K
R
A
N
L
V
Q
------------------
E
R
E
M
L
N
T
I
L
A
A
N
E
G
P
F
E
D
S
T
V
Q
K
L
F
K
E
I
F
K
A
G
L
------
H
S
K
A
L
L
V
S
R
K
N
K
K
E
D
T
I
V
T
V
K
G
L
P
I
G
N
G
E
P
V
F
V
F
G
P
C
S
V
E
S
Y
E
Q
V
A
A
V
A
E
S
I
K
A
-----
K
G
L
K
L
I
R
G
G
A
F
K
P
--
R
T
S
P
Y
D
F
Q
G
L
G
L
E
-
G
L
K
I
L
K
R
V
S
D
E
Y
G
L
G
V
I
S
E
I
V
T
P
A
D
I
E
V
A
L
D
Y
V
D
V
I
Q
I
G
A
R
N
M
Q
N
F
E
L
L
K
A
A
G
R
V
D
K
P
I
L
L
K
R
G
L
S
A
T
I
E
E
F
I
G
A
A
E
Y
I
M
S
Q
G
N
G
K
I
I
L
C
E
R
G
I
--
R
T
Y
E
-
K
A
T
R
N
T
L
--
D
I
S
A
V
P
I
L
K
K
E
T
H
L
P
V
M
V
D
V
T
H
S
T
-----------
G
R
K
D
L
L
L
P
C
A
K
A
A
L
A
I
E
A
D
G
V
M
A
E
V
H
P
D
P
A
V
A
L
--
S
D
S
A
Q
Q
M
D
I
P
E
F
E
E
F
W
N
A
I
-------------
22
PsiBlast_CBE
93.41
76%
-104
- C2 -
3NVT
2
?
B:
[30-374]
-----
L
E
E
L
R
T
Q
V
D
Q
L
N
I
D
L
L
E
L
I
S
K
R
A
N
L
V
Q
--------------------
E
M
L
N
T
I
L
A
A
N
E
G
P
F
E
D
S
T
V
Q
K
L
F
K
E
I
F
K
A
G
L
E
L
Q
----
S
K
A
L
L
V
S
R
K
N
K
K
E
D
T
I
V
T
V
K
G
L
P
I
G
N
G
E
P
V
F
V
F
G
P
C
S
V
E
S
Y
E
Q
V
A
A
V
A
E
S
I
K
A
-----
K
G
L
K
L
I
R
G
G
A
F
K
P
--
R
T
S
P
Y
D
F
Q
G
L
G
L
E
-
G
L
K
I
L
K
R
V
S
D
E
Y
G
L
G
V
I
S
E
I
V
T
P
A
D
I
E
V
A
L
D
Y
V
D
V
I
Q
I
G
A
R
N
M
Q
N
F
E
L
L
K
A
A
G
R
V
D
K
P
I
L
L
K
R
G
L
S
A
T
I
E
E
F
I
G
A
A
E
Y
I
M
S
Q
G
N
G
K
I
I
L
C
E
R
G
I
--
R
T
Y
E
-
K
A
T
R
N
T
L
--
D
I
S
A
V
P
I
L
K
K
E
T
H
L
P
V
M
V
D
V
T
H
S
T
-----------
G
R
K
D
L
L
L
P
C
A
K
A
A
L
A
I
E
A
D
G
V
M
A
E
V
H
P
D
P
A
V
A
L
--
S
D
S
A
Q
Q
M
D
I
P
E
F
E
E
F
W
N
A
I
-------------
104
HHSearch
88.01
72%
-68
- C2 -
3NVT
2
?
A:
[32-381]
-------
E
L
R
T
Q
V
D
Q
L
N
I
D
L
L
E
L
I
S
K
R
A
N
L
V
Q
E
I
G
K
I
K
G
-----
R
F
D
P
L
R
E
R
E
M
L
N
T
I
L
A
A
N
E
G
P
F
E
D
S
T
V
Q
K
L
F
K
E
I
F
K
A
G
L
E
L
Q
E
E
D
H
S
K
A
L
L
V
S
R
K
N
K
K
E
D
T
I
V
T
V
K
G
L
P
I
G
N
G
E
P
V
F
V
F
G
P
C
S
V
E
S
Y
E
Q
V
A
A
V
A
E
S
I
K
A
-----
K
G
L
K
L
I
R
G
G
A
F
K
P
--
R
T
S
P
Y
D
F
Q
G
L
G
L
E
-
G
L
K
I
L
K
R
V
S
D
E
Y
G
L
G
V
I
S
E
I
V
T
P
A
D
I
E
V
A
L
D
Y
V
D
V
I
Q
I
G
A
R
N
M
Q
N
F
E
L
L
K
A
A
G
R
V
D
K
P
I
L
L
K
R
G
L
S
A
T
I
E
E
F
I
G
A
A
E
Y
I
M
S
Q
G
N
G
K
I
I
L
C
E
R
G
I
--
R
T
Y
E
K
A
-
T
R
N
T
L
--
D
I
S
A
V
P
I
L
K
K
E
T
H
L
P
V
M
V
D
V
T
H
S
T
-----------
G
R
K
D
L
L
L
P
C
A
K
A
A
L
A
I
E
A
D
--
G
V
M
A
E
V
H
P
D
P
A
V
AL
S
D
S
A
Q
Q
M
D
I
P
E
F
E
E
F
W
N
A
I
L
A
S
-----
N
L
V
P
-
8
PsiBlast_PDB
80.75
55%
-102
- C2 -
4C1K
3
?
A:
[5-258]
--------------------------------------------------------------------------------------------------
K
E
Y
K
E
K
T
V
V
K
I
N
D
V
K
F
G
E
G
F
T
-
I
I
A
G
P
C
S
I
E
S
R
D
Q
I
M
K
V
A
E
F
L
A
E
-----
V
G
I
K
V
L
R
G
G
A
F
K
P
--
R
T
S
P
Y
S
F
Q
G
Y
G
E
K
-
A
L
R
W
M
R
E
A
A
D
E
Y
G
L
V
T
V
T
E
V
M
D
T
R
H
V
E
L
V
A
K
Y
S
D
I
L
Q
I
G
A
R
N
S
Q
N
F
E
L
L
K
E
V
G
K
V
E
N
P
V
L
L
K
R
G
M
G
N
T
I
Q
E
L
L
Y
S
A
E
Y
I
M
A
Q
G
N
E
N
V
I
L
C
E
R
G
I
--
R
T
F
E
-
T
A
T
R
F
T
L
--
D
I
S
A
V
P
V
V
K
E
L
S
H
L
P
I
I
V
D
P
S
H
P
A
-----------
G
R
R
S
L
V
I
P
L
A
K
A
A
Y
A
I
G
A
D
G
I
M
V
E
V
H
P
E
P
E
K
A
L
--
S
D
S
Q
Q
Q
L
T
F
D
D
F
L
Q
L
L
K
E
L
E
A
L
----------
34
PsiBlast_CBE
79.71
55%
-103
- C2 -
1ZCO
3
?
B:
[5-258]
--------------------------------------------------------------------------------------------------
K
E
Y
D
E
K
T
V
V
K
I
N
D
V
K
F
G
E
G
F
T
-
I
I
A
G
P
C
S
I
E
S
R
E
Q
I
M
K
V
A
E
F
L
A
E
-----
V
G
I
K
V
L
R
G
G
A
F
K
P
--
R
T
S
P
Y
S
F
Q
G
Y
G
E
K
-
A
L
R
W
M
R
E
A
A
D
E
Y
G
L
V
T
V
T
E
V
M
D
T
R
H
V
E
L
V
A
K
Y
S
D
I
L
Q
I
G
A
R
N
S
Q
N
F
E
L
L
K
E
V
G
K
V
E
N
P
V
L
L
K
R
G
M
G
N
T
I
Q
E
L
L
Y
S
A
E
Y
I
M
A
Q
G
N
E
N
V
I
L
C
E
R
G
I
--
R
T
F
E
-
T
A
T
R
F
T
L
--
D
I
S
A
V
P
V
V
K
E
L
S
H
L
P
I
I
V
D
P
S
H
P
A
-----------
G
R
R
S
L
V
I
P
L
A
K
A
A
Y
A
I
G
A
D
G
I
M
V
E
V
H
P
E
P
E
K
A
L
--
S
D
S
Q
Q
Q
L
T
F
D
D
F
L
Q
L
L
K
E
L
E
A
L
----------
35
PsiBlast_CBE
79.19
55%
-96
- C2 -
4C1K
3
?
F:
[5-258]
--------------------------------------------------------------------------------------------------
K
E
Y
K
E
K
T
V
V
K
I
N
D
V
K
F
G
E
G
F
T
-
I
I
A
G
P
C
S
I
E
S
R
D
Q
I
M
K
V
A
E
F
L
A
E
-----
V
G
I
K
V
L
R
G
G
A
F
K
P
--
R
T
S
P
Y
S
F
Q
G
Y
G
E
K
-
A
L
R
W
M
R
E
A
A
D
E
Y
G
L
V
T
V
T
E
V
M
D
T
R
H
V
E
L
V
A
K
Y
S
D
I
L
Q
I
G
A
R
N
S
Q
N
F
E
L
L
K
E
V
G
K
V
E
N
P
V
L
L
K
R
G
M
G
N
T
I
Q
E
L
L
Y
S
A
E
Y
I
M
A
Q
G
N
E
N
V
I
L
C
E
R
G
I
--
R
T
F
E
-
T
A
T
R
F
T
L
--
D
I
S
A
V
P
V
V
K
E
L
S
H
L
P
I
I
V
D
P
S
H
P
A
-----------
G
R
R
S
L
V
I
P
L
A
K
A
A
Y
A
I
G
A
D
G
I
M
V
E
V
H
P
E
P
E
K
A
L
--
S
D
S
Q
Q
Q
L
T
F
D
D
F
L
Q
L
L
K
E
L
E
A
L
----------
38
PsiBlast_CBE
79.13
55%
-99
- C2 -
4C1K
3
?
C:
[5-258]
--------------------------------------------------------------------------------------------------
K
E
Y
K
E
K
T
V
V
K
I
N
D
V
K
F
G
E
G
F
T
-
I
I
A
G
P
C
S
I
E
S
R
D
Q
I
M
K
V
A
E
F
L
A
E
-----
V
G
I
K
V
L
R
G
G
A
F
K
P
--
R
T
S
P
Y
S
F
Q
G
Y
G
E
K
-
A
L
R
W
M
R
E
A
A
D
E
Y
G
L
V
T
V
T
E
V
M
D
T
R
H
V
E
L
V
A
K
Y
S
D
I
L
Q
I
G
A
R
N
S
Q
N
F
E
L
L
K
E
V
G
K
V
E
N
P
V
L
L
K
R
G
M
G
N
T
I
Q
E
L
L
Y
S
A
E
Y
I
M
A
Q
G
N
E
N
V
I
L
C
E
R
G
I
--
R
T
F
E
-
T
A
T
R
F
T
L
--
D
I
S
A
V
P
V
V
K
E
L
S
H
L
P
I
I
V
D
P
S
H
P
A
-----------
G
R
R
S
L
V
I
P
L
A
K
A
A
Y
A
I
G
A
D
G
I
M
V
E
V
H
P
E
P
E
K
A
L
--
S
D
S
Q
Q
Q
L
T
F
D
D
F
L
Q
L
L
K
E
L
E
A
L
----------
40
PsiBlast_CBE
79.07
54%
-97
- C2 -
4C1L
6
?
B:
[5-258]
--------------------------------------------------------------------------------------------------
K
E
Y
K
E
K
T
V
V
K
I
N
D
V
K
F
G
E
G
F
T
-
I
I
A
G
P
C
S
I
E
S
R
D
Q
I
M
K
V
A
E
F
L
A
E
-----
V
G
I
K
V
L
R
G
G
A
F
K
P
--
R
T
S
P
Y
S
F
Q
G
Y
G
E
K
-
A
L
R
W
M
R
E
A
A
D
E
Y
G
L
V
T
V
T
E
V
M
D
T
R
H
V
E
L
V
A
K
Y
S
D
I
L
Q
I
G
A
R
N
S
Q
N
F
E
L
L
K
E
V
G
K
V
E
N
P
V
L
L
K
R
G
M
G
N
T
I
Q
E
L
L
Y
S
A
E
Y
I
M
A
Q
G
N
E
N
V
I
L
C
E
R
G
I
--
R
T
F
E
-
T
A
T
R
F
T
L
--
D
D
S
A
V
P
V
V
K
E
L
S
H
L
P
I
I
V
D
P
S
H
P
A
-----------
G
R
R
S
L
V
I
P
L
A
K
A
A
Y
A
I
G
A
D
G
I
M
V
E
V
H
P
E
P
E
K
A
L
--
S
D
S
Q
Q
Q
L
T
F
D
D
F
L
Q
L
L
K
E
L
E
A
L
----------
29
PsiBlast_CBE
79.05
53%
-102
- C2 -
3PG9
2
AROF_THEMA
E:
[71-338]
----------------------------------------------------------------------------------------------
L
V
S
R
E
F
H
P
E
D
T
V
I
D
L
G
D
V
K
I
G
N
G
Y
F
T
I
I
A
G
P
C
S
V
E
G
R
E
M
L
M
E
T
A
H
F
L
S
E
-----
L
G
V
K
V
L
R
G
G
A
Y
K
P
--
R
T
S
P
Y
S
F
Q
G
L
G
E
K
-
G
L
E
Y
L
R
E
A
A
D
K
Y
G
M
Y
V
V
T
E
A
L
G
E
D
D
L
P
K
V
A
E
Y
A
D
I
I
Q
I
G
A
R
N
A
Q
N
F
R
L
L
S
K
A
G
S
Y
N
K
P
V
L
L
K
R
G
F
M
N
T
I
E
E
F
L
L
S
A
E
Y
I
A
N
S
G
N
T
K
I
I
L
C
E
R
G
I
--
R
T
F
E
-
K
A
T
R
N
T
L
--
D
I
S
A
V
P
I
I
R
K
E
S
H
L
P
I
L
V
D
P
S
H
S
G
-----------
G
R
R
D
L
V
I
P
L
S
R
A
A
I
A
V
G
A
H
G
I
I
V
E
V
H
P
E
P
E
K
A
L
--
S
D
G
K
Q
S
L
D
F
E
L
F
K
E
L
V
Q
E
M
K
K
L
ADALG
V
K
V
N
-
39
PsiBlast_CBE
78.84
55%
-102
- C2 -
4C1K
3
?
B:
[5-258]
--------------------------------------------------------------------------------------------------
K
E
Y
K
E
K
T
V
V
K
I
N
D
V
K
F
G
E
G
F
T
-
I
I
A
G
P
C
S
I
E
S
R
D
Q
I
M
K
V
A
E
F
L
A
E
-----
V
G
I
K
V
L
R
G
G
A
F
K
P
--
R
T
S
P
Y
S
F
Q
G
Y
G
E
K
-
A
L
R
W
M
R
E
A
A
D
E
Y
G
L
V
T
V
T
E
V
M
D
T
R
H
V
E
L
V
A
K
Y
S
D
I
L
Q
I
G
A
R
N
S
Q
N
F
E
L
L
K
E
V
G
K
V
E
N
P
V
L
L
K
R
G
M
G
N
T
I
Q
E
L
L
Y
S
A
E
Y
I
M
A
Q
G
N
E
N
V
I
L
C
E
R
G
I
--
R
T
F
E
-
T
A
T
R
F
T
L
--
D
I
S
A
V
P
V
V
K
E
L
S
H
L
P
I
I
V
D
P
S
H
P
A
-----------
G
R
R
S
L
V
I
P
L
A
K
A
A
Y
A
I
G
A
D
G
I
M
V
E
V
H
P
E
P
E
K
A
L
--
S
D
S
Q
Q
Q
L
T
F
D
D
F
L
Q
L
L
K
E
L
E
A
L
----------
37
PsiBlast_CBE
78.77
55%
-97
- C2 -
4C1K
3
?
D:
[5-258]
--------------------------------------------------------------------------------------------------
K
E
Y
K
E
K
T
V
V
K
I
N
D
V
K
F
G
E
G
F
T
-
I
I
A
G
P
C
S
I
E
S
R
D
Q
I
M
K
V
A
E
F
L
A
E
-----
V
G
I
K
V
L
R
G
G
A
F
K
P
--
R
T
S
P
Y
S
F
Q
G
Y
G
E
K
-
A
L
R
W
M
R
E
A
A
D
E
Y
G
L
V
T
V
T
E
V
M
D
T
R
H
V
E
L
V
A
K
Y
S
D
I
L
Q
I
G
A
R
N
S
Q
N
F
E
L
L
K
E
V
G
K
V
E
N
P
V
L
L
K
R
G
M
G
N
T
I
Q
E
L
L
Y
S
A
E
Y
I
M
A
Q
G
N
E
N
V
I
L
C
E
R
G
I
--
R
T
F
E
-
T
A
T
R
F
T
L
--
D
I
S
A
V
P
V
V
K
E
L
S
H
L
P
I
I
V
D
P
S
H
P
A
-----------
G
R
R
S
L
V
I
P
L
A
K
A
A
Y
A
I
G
A
D
G
I
M
V
E
V
H
P
E
P
E
K
A
L
--
S
D
S
Q
Q
Q
L
T
F
D
D
F
L
Q
L
L
K
E
L
E
A
L
----------
26
PsiBlast_CBE
78.65
53%
-102
- C2 -
3PG9
2
AROF_THEMA
H:
[71-338]
----------------------------------------------------------------------------------------------
L
V
S
R
E
F
H
P
E
D
T
V
I
D
L
G
D
V
K
I
G
N
G
Y
F
T
I
I
A
G
P
C
S
V
E
G
R
E
M
L
M
E
T
A
H
F
L
S
E
-----
L
G
V
K
V
L
R
G
G
A
Y
K
P
--
R
T
S
P
Y
S
F
Q
G
L
G
E
K
-
G
L
E
Y
L
R
E
A
A
D
K
Y
G
M
Y
V
V
T
E
A
L
G
E
D
D
L
P
K
V
A
E
Y
A
D
I
I
Q
I
G
A
R
N
A
Q
N
F
R
L
L
S
K
A
G
S
Y
N
K
P
V
L
L
K
R
G
F
M
N
T
I
E
E
F
L
L
S
A
E
Y
I
A
N
S
G
N
T
K
I
I
L
C
E
R
G
I
--
R
T
F
E
-
K
A
T
R
N
T
L
--
D
I
S
A
V
P
I
I
R
K
E
S
H
L
P
I
L
V
D
P
S
H
S
G
-----------
G
R
R
D
L
V
I
P
L
S
R
A
A
I
A
V
G
A
H
G
I
I
V
E
V
H
P
E
P
E
K
A
L
--
S
D
G
K
Q
S
L
D
F
E
L
F
K
E
L
V
Q
E
M
K
K
L
ADALG
V
K
V
N
-
36
PsiBlast_CBE
78.64
55%
-100
- C2 -
4C1K
4
?
E:
[5-258]
--------------------------------------------------------------------------------------------------
K
E
Y
K
E
K
T
V
V
K
I
N
D
V
K
F
G
E
G
F
T
-
I
I
A
G
P
C
S
I
E
S
R
D
Q
I
M
K
V
A
E
F
L
A
E
-----
V
G
I
K
V
L
R
G
G
A
F
K
P
--
R
T
S
P
Y
S
F
Q
G
Y
G
E
K
-
A
L
R
W
M
R
E
A
A
D
E
Y
G
L
V
T
V
T
E
V
M
D
T
R
H
V
E
L
V
A
K
Y
S
D
I
L
Q
I
G
A
R
N
S
Q
N
F
E
L
L
K
E
V
G
K
V
E
N
P
V
L
L
K
R
G
M
G
N
T
I
Q
E
L
L
Y
S
A
E
Y
I
M
A
Q
G
N
E
N
V
I
L
C
E
R
G
I
--
R
T
F
E
-
T
A
T
R
F
T
L
--
D
I
S
A
V
P
V
V
K
E
L
S
H
L
P
I
I
V
D
P
S
H
P
A
-----------
G
R
R
S
L
V
I
P
L
A
K
A
A
Y
A
I
G
A
D
G
I
M
V
E
V
H
P
E
P
E
K
A
L
--
S
D
S
Q
Q
Q
L
T
F
D
D
F
L
Q
L
L
K
E
L
E
A
L
----------
9
PsiBlast_PDB
78.64
54%
-95
- C2 -
4C1L
4
?
A:
[5-258]
--------------------------------------------------------------------------------------------------
K
E
Y
K
E
K
T
V
V
K
I
N
D
V
K
F
G
E
G
F
T
-
I
I
A
G
P
C
S
I
E
S
R
D
Q
I
M
K
V
A
E
F
L
A
E
-----
V
G
I
K
V
L
R
G
G
A
F
K
P
--
R
T
S
P
Y
S
F
Q
G
Y
G
E
K
-
A
L
R
W
M
R
E
A
A
D
E
Y
G
L
V
T
V
T
E
V
M
D
T
R
H
V
E
L
V
A
K
Y
S
D
I
L
Q
I
G
A
R
N
S
Q
N
F
E
L
L
K
E
V
G
K
V
E
N
P
V
L
L
K
R
G
M
G
N
T
I
Q
E
L
L
Y
S
A
E
Y
I
M
A
Q
G
N
E
N
V
I
L
C
E
R
G
I
--
R
T
F
E
-
T
A
T
R
F
T
L
--
D
D
S
A
V
P
V
V
K
E
L
S
H
L
P
I
I
V
D
P
S
H
P
A
-----------
G
R
R
S
L
V
I
P
L
A
K
A
A
Y
A
I
G
A
D
G
I
M
V
E
V
H
P
E
P
E
K
A
L
--
S
D
S
Q
Q
Q
L
T
F
D
D
F
L
Q
L
L
K
E
L
E
A
L
----------
33
PsiBlast_CBE
78.63
53%
-103
- C2 -
1RZM
4
AROF_THEMA
B:
[71-338]
----------------------------------------------------------------------------------------------
L
V
S
R
E
F
H
P
E
D
T
V
I
D
L
G
D
V
K
I
G
N
G
Y
F
T
I
I
A
G
P
C
S
V
E
G
R
E
M
L
M
E
T
A
H
F
L
S
E
-----
L
G
V
K
V
L
R
G
G
A
Y
K
P
--
R
T
S
P
Y
S
F
Q
G
L
G
E
K
-
G
L
E
Y
L
R
E
A
A
D
K
Y
G
M
Y
V
V
T
E
A
L
G
E
D
D
L
P
K
V
A
E
Y
A
D
I
I
Q
I
G
A
R
N
A
Q
N
F
R
L
L
S
K
A
G
S
Y
N
K
P
V
L
L
K
R
G
F
M
N
T
I
E
E
F
L
L
S
A
E
Y
I
A
N
S
G
N
T
K
I
I
L
C
E
R
G
I
--
R
T
F
E
-
K
A
T
R
N
T
L
--
D
I
S
A
V
P
I
I
R
K
E
S
H
L
P
I
L
V
D
P
S
H
S
G
-----------
G
R
R
D
L
V
I
P
L
S
R
A
A
I
A
V
G
A
H
G
I
I
V
E
V
H
P
E
P
E
K
A
L
--
S
D
G
K
Q
S
L
D
F
E
L
F
K
E
L
V
Q
E
M
K
K
L
ADALG
V
K
V
N
-
3
PsiBlast_PDB
78.63
56%
-107
- C2 -
4GRS
-
AROF_THEMA
A:
[71-329]
----------------------------------------------------------------------------------------------
L
V
S
R
E
F
H
P
E
D
T
V
I
D
L
G
D
V
K
I
G
N
G
Y
F
T
I
I
A
G
P
C
S
I
E
S
R
D
Q
I
M
K
V
A
E
F
L
A
E
-----
V
G
I
K
V
L
R
G
G
A
F
K
P
--
R
T
S
P
Y
S
F
Q
G
Y
G
E
K
-
A
L
R
W
M
R
E
A
A
D
E
Y
G
L
V
T
V
T
E
V
M
D
T
R
H
V
E
L
V
A
K
Y
S
D
I
L
Q
I
G
A
R
N
S
Q
N
F
E
L
L
K
E
V
G
K
V
E
N
P
V
L
L
K
R
G
M
G
N
T
I
Q
E
L
L
Y
S
A
E
Y
I
M
A
Q
G
N
E
N
V
I
L
C
E
R
G
I
--
R
T
F
E
-
T
A
T
R
F
T
L
--
D
I
S
A
V
P
V
V
K
E
L
S
H
L
P
I
I
V
D
P
S
H
P
A
-----------
G
R
R
S
L
V
I
P
L
A
K
A
A
Y
A
I
G
A
D
G
I
M
V
E
V
H
P
E
P
E
K
A
L
--
S
D
S
Q
Q
Q
L
T
F
D
D
F
L
Q
L
L
K
E
L
E
A
L
----------
32
PsiBlast_CBE
78.39
53%
-99
- C2 -
3PG9
4
AROF_THEMA
B:
[71-338]
----------------------------------------------------------------------------------------------
L
V
S
R
E
F
H
P
E
D
T
V
I
D
L
G
D
V
K
I
G
N
G
Y
F
T
I
I
A
G
P
C
S
V
E
G
R
E
M
L
M
E
T
A
H
F
L
S
E
-----
L
G
V
K
V
L
R
G
G
A
Y
K
P
--
R
T
S
P
Y
S
F
Q
G
L
G
E
K
-
G
L
E
Y
L
R
E
A
A
D
K
Y
G
M
Y
V
V
T
E
A
L
G
E
D
D
L
P
K
V
A
E
Y
A
D
I
I
Q
I
G
A
R
N
A
Q
N
F
R
L
L
S
K
A
G
S
Y
N
K
P
V
L
L
K
R
G
F
M
N
T
I
E
E
F
L
L
S
A
E
Y
I
A
N
S
G
N
T
K
I
I
L
C
E
R
G
I
--
R
T
F
E
-
K
A
T
R
N
T
L
--
D
I
S
A
V
P
I
I
R
K
E
S
H
L
P
I
L
V
D
P
S
H
S
G
-----------
G
R
R
D
L
V
I
P
L
S
R
A
A
I
A
V
G
A
H
G
I
I
V
E
V
H
P
E
P
E
K
A
L
--
S
D
G
K
Q
S
L
D
F
E
L
F
K
E
L
V
Q
E
M
K
K
L
ADALG
V
K
V
N
-
41
PsiBlast_CBE
78.25
55%
-100
- C2 -
1VS1
2
?
D:
[24-271]
-------------------------------------------------------------------------------------------------------
E
T
V
V
E
V
E
G
V
R
I
G
G
G
S
K
A
V
I
A
G
P
C
S
V
E
S
W
E
Q
V
R
E
A
A
L
A
V
K
E
-----
A
G
A
H
M
L
R
G
G
A
F
K
P
--
R
T
S
P
Y
S
F
Q
G
L
G
L
E
-
G
L
K
L
L
R
R
A
G
D
E
A
G
L
P
V
V
T
E
V
L
D
P
R
H
V
E
T
V
S
R
Y
A
D
M
L
Q
I
G
A
R
N
M
Q
N
F
P
L
L
R
E
V
G
R
S
G
K
P
V
L
L
K
R
G
F
G
N
T
V
E
E
L
L
A
A
A
E
Y
I
L
L
E
G
N
W
Q
V
V
L
V
E
R
G
I
--
R
T
F
E
-
P
S
T
R
F
T
L
--
D
V
A
A
V
A
V
L
K
E
A
T
H
L
P
V
I
V
D
P
S
H
P
A
-----------
G
R
R
S
L
V
P
A
L
A
K
A
G
L
A
A
G
A
D
G
L
I
V
E
V
H
P
N
P
E
E
A
L
--
S
D
A
K
Q
Q
L
T
P
G
E
F
A
R
L
M
G
E
L
R
------------
4
PsiBlast_PDB
78.18
53%
-100
- C2 -
1RZM
3
AROF_THEMA
A:
[71-338]
----------------------------------------------------------------------------------------------
L
V
S
R
E
F
H
P
E
D
T
V
I
D
L
G
D
V
K
I
G
N
G
Y
F
T
I
I
A
G
P
C
S
V
E
G
R
E
M
L
M
E
T
A
H
F
L
S
E
-----
L
G
V
K
V
L
R
G
G
A
Y
K
P
--
R
T
S
P
Y
S
F
Q
G
L
G
E
K
-
G
L
E
Y
L
R
E
A
A
D
K
Y
G
M
Y
V
V
T
E
A
L
G
E
D
D
L
P
K
V
A
E
Y
A
D
I
I
Q
I
G
A
R
N
A
Q
N
F
R
L
L
S
K
A
G
S
Y
N
K
P
V
L
L
K
R
G
F
M
N
T
I
E
E
F
L
L
S
A
E
Y
I
A
N
S
G
N
T
K
I
I
L
C
E
R
G
I
--
R
T
F
E
-
K
A
T
R
N
T
L
--
D
I
S
A
V
P
I
I
R
K
E
S
H
L
P
I
L
V
D
P
S
H
S
G
-----------
G
R
R
D
L
V
I
P
L
S
R
A
A
I
A
V
G
A
H
G
I
I
V
E
V
H
P
E
P
E
K
A
L
--
S
D
G
K
Q
S
L
D
F
E
L
F
K
E
L
V
Q
E
M
K
K
L
A
D
A
L
G
V
K
V
N
-
42
PsiBlast_CBE
77.48
55%
-99
- C2 -
1VS1
2
?
C:
[24-271]
-------------------------------------------------------------------------------------------------------
E
T
V
V
E
V
E
G
V
R
I
G
G
G
S
K
A
V
I
A
G
P
C
S
V
E
S
W
E
Q
V
R
E
A
A
L
A
V
K
E
-----
A
G
A
H
M
L
R
G
G
A
F
K
P
--
R
T
S
P
Y
S
F
Q
G
L
G
L
E
-
G
L
K
L
L
R
R
A
G
D
E
A
G
L
P
V
V
T
E
V
L
D
P
R
H
V
E
T
V
S
R
Y
A
D
M
L
Q
I
G
A
R
N
M
Q
N
F
P
L
L
R
E
V
G
R
S
G
K
P
V
L
L
K
R
G
F
G
N
T
V
E
E
L
L
A
A
A
E
Y
I
L
L
E
G
N
W
Q
V
V
L
V
E
R
G
I
--
R
T
F
E
-
P
S
T
R
F
T
L
--
D
V
A
A
V
A
V
L
K
E
A
T
H
L
P
V
I
V
D
P
S
H
P
A
-----------
G
R
R
S
L
V
P
A
L
A
K
A
G
L
A
A
G
A
D
G
L
I
V
E
V
H
P
N
P
E
E
A
L
--
S
D
A
K
Q
Q
L
T
P
G
E
F
A
R
L
M
G
E
L
R
------------
43
PsiBlast_CBE
77.36
55%
-102
- C2 -
1VS1
2
?
B:
[24-271]
-------------------------------------------------------------------------------------------------------
E
T
V
V
E
V
E
G
V
R
I
G
G
G
S
K
A
V
I
A
G
P
C
S
V
E
S
W
E
Q
V
R
E
A
A
L
A
V
K
E
-----
A
G
A
H
M
L
R
G
G
A
F
K
P
--
R
T
S
P
Y
S
F
Q
G
L
G
L
E
-
G
L
K
L
L
R
R
A
G
D
E
A
G
L
P
V
V
T
E
V
L
D
P
R
H
V
E
T
V
S
R
Y
A
D
M
L
Q
I
G
A
R
N
M
Q
N
F
P
L
L
R
E
V
G
R
S
G
K
P
V
L
L
K
R
G
F
G
N
T
V
E
E
L
L
A
A
A
E
Y
I
L
L
E
G
N
W
Q
V
V
L
V
E
R
G
I
--
R
T
F
E
-
P
S
T
R
F
T
L
--
D
V
A
A
V
A
V
L
K
E
A
T
H
L
P
V
I
V
D
P
S
H
P
A
-----------
G
R
R
S
L
V
P
A
L
A
K
A
G
L
A
A
G
A
D
G
L
I
V
E
V
H
P
N
P
E
E
A
L
--
S
D
A
K
Q
Q
L
T
P
G
E
F
A
R
L
M
G
E
L
R
------------
10
PsiBlast_PDB
77.33
55%
-98
- C2 -
1VS1
2
?
A:
[24-271]
-------------------------------------------------------------------------------------------------------
E
T
V
V
E
V
E
G
V
R
I
G
G
G
S
K
A
V
I
A
G
P
C
S
V
E
S
W
E
Q
V
R
E
A
A
L
A
V
K
E
-----
A
G
A
H
M
L
R
G
G
A
F
K
P
--
R
T
S
P
Y
S
F
Q
G
L
G
L
E
-
G
L
K
L
L
R
R
A
G
D
E
A
G
L
P
V
V
T
E
V
L
D
P
R
H
V
E
T
V
S
R
Y
A
D
M
L
Q
I
G
A
R
N
M
Q
N
F
P
L
L
R
E
V
G
R
S
G
K
P
V
L
L
K
R
G
F
G
N
T
V
E
E
L
L
A
A
A
E
Y
I
L
L
E
G
N
W
Q
V
V
L
V
E
R
G
I
--
R
T
F
E
-
P
S
T
R
F
T
L
--
D
V
A
A
V
A
V
L
K
E
A
T
H
L
P
V
I
V
D
P
S
H
P
A
-----------
G
R
R
S
L
V
P
A
L
A
K
A
G
L
A
A
G
A
D
G
L
I
V
E
V
H
P
N
P
E
E
A
L
--
S
D
A
K
Q
Q
L
T
P
G
E
F
A
R
L
M
G
E
L
R
------------
7
PsiBlast_PDB
77.24
55%
-100
- C2 -
1ZCO
2
?
A:
[5-258]
--------------------------------------------------------------------------------------------------
K
E
Y
D
E
K
T
V
V
K
I
N
D
V
K
F
G
E
G
F
T
-
I
I
A
G
P
C
S
I
E
S
R
E
Q
I
M
K
V
A
E
F
L
A
E
-----
V
G
I
K
V
L
R
G
G
A
F
K
P
--
R
T
S
P
Y
S
F
Q
G
Y
G
E
K
-
A
L
R
W
M
R
E
A
A
D
E
Y
G
L
V
T
V
T
E
V
M
D
T
R
H
V
E
L
V
A
K
Y
S
D
I
L
Q
I
G
A
R
N
S
Q
N
F
E
L
L
K
E
V
G
K
V
E
N
P
V
L
L
K
R
G
M
G
N
T
I
Q
E
L
L
Y
S
A
E
Y
I
M
A
Q
G
N
E
N
V
I
L
C
E
R
G
I
--
R
T
F
E
-
T
A
T
R
F
T
L
--
D
I
S
A
V
P
V
V
K
E
L
S
H
L
P
I
I
V
D
P
S
H
P
A
-----------
G
R
R
S
L
V
I
P
L
A
K
A
A
Y
A
I
G
A
D
G
I
M
V
E
V
H
P
E
P
E
K
A
L
--
S
D
S
Q
Q
Q
L
T
F
D
D
F
L
Q
L
L
K
E
L
E
A
L
----------
106
HHSearch
71.82
51%
-62
- C2 -
1VS1
2
?
A:
[14-276]
---------------------------------------------------------------------------------------------
K
L
A
L
K
S
E
E
R
R
E
T
V
V
E
V
E
G
V
R
I
G
G
G
S
K
A
V
I
A
G
P
C
S
V
E
S
W
E
Q
V
R
E
A
A
L
A
V
K
E
-----
A
G
A
H
M
L
R
G
G
A
F
K
P
--
R
T
S
P
Y
S
F
Q
G
L
G
L
E
-
G
L
K
L
L
R
R
A
G
D
E
A
G
L
P
V
V
T
E
V
L
D
P
R
H
V
E
T
V
S
R
Y
A
D
M
L
Q
I
G
A
R
N
M
Q
N
F
P
L
L
R
E
V
G
R
S
G
K
P
V
L
L
K
R
G
F
G
N
T
V
E
E
L
L
A
A
A
E
Y
I
L
L
E
G
N
W
Q
V
V
L
V
E
-
R
G
I
R
T
F
E
P
-
S
T
-
R
F
T
L
--
D
V
A
A
V
A
V
L
K
E
A
T
H
L
P
V
I
V
D
P
S
H
P
A
-----------
G
R
R
S
L
V
P
A
L
A
K
A
G
L
A
A
G
A
D
G
L
I
V
E
V
H
P
N
P
E
E
A
L
--
S
D
A
K
Q
Q
L
T
P
G
E
F
A
R
L
M
G
E
L
R
W
H
-----
R
L
L
--
47
PsiBlast_CBE
52.32
31%
6
- C2 -
3E0I
4
KDSA_AQUAE
A:
[7-244]
-------------------------------------------------------------------------------------------------------------------------
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
K
F
K
E
V
E
F
V
F
K
S
S
F
D
K
AN
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
N
V
V
E
K
L
K
F
G
G
A
K
E
I
Y
L
T
E
R
G
T
-------
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
A
K
--
V
I
Y
D
A
T
H
S
V
QLPGGLGD
K
S
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
V
G
C
D
G
V
F
M
E
T
H
P
E
P
E
K
A
L
--
S
D
A
S
T
Q
L
P
L
S
Q
L
E
-------------------
13
PsiBlast_PDB
52.11
31%
8
- C2 -
1FWT
4
KDSA_AQUAE
A:
[7-244]
-------------------------------------------------------------------------------------------------------------------------
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
K
F
K
E
V
E
F
V
F
K
S
S
F
D
K
AN
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
N
V
V
E
K
L
K
F
G
G
A
K
E
I
Y
L
T
E
R
G
T
-------
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
A
K
--
V
I
Y
D
A
T
H
S
V
Q
L
P
GGLGD
K
S
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
V
G
C
D
G
V
F
M
E
T
H
P
E
P
E
K
A
L
--
S
D
A
S
T
Q
L
P
L
S
Q
L
E
-------------------
76
PsiBlast_CBE
52.04
31%
12
- C2 -
1T8X
3
KDSA_AQUAE
B:
[7-244]
-------------------------------------------------------------------------------------------------------------------------
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
K
F
K
E
V
E
F
V
F
K
S
S
F
D
K
AN
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
G
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
N
V
V
E
K
L
K
F
G
G
A
K
E
I
Y
L
T
E
R
G
T
-------
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
A
K
--
V
I
Y
D
A
T
H
S
V
QLPGG------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
V
G
C
D
G
V
F
M
E
T
H
P
E
P
E
K
A
L
--
S
D
A
S
T
Q
L
P
L
S
Q
L
E
-------------------
14
PsiBlast_PDB
51.92
31%
9
- C2 -
1FWW
4
KDSA_AQUAE
A:
[7-244]
-------------------------------------------------------------------------------------------------------------------------
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
K
F
K
E
V
E
F
V
F
K
S
S
F
D
K
AN
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
N
V
V
E
K
L
K
F
G
G
A
K
E
I
Y
L
T
E
R
G
T
-------
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
A
K
--
V
I
Y
D
A
T
H
S
V
Q
L
P
GGLGD
K
S
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
V
G
C
D
G
V
F
M
E
T
H
P
E
P
E
K
A
L
--
S
D
A
S
T
Q
L
P
L
S
Q
L
E
-------------------
51
PsiBlast_CBE
51.54
31%
9
- C2 -
2A21
4
KDSA_AQUAE
A:
[7-244]
-------------------------------------------------------------------------------------------------------------------------
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
K
F
K
E
V
E
F
V
F
K
S
S
F
D
K
AN
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
N
V
V
E
K
L
K
F
G
G
A
K
E
I
Y
L
T
E
R
G
T
-------
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
A
K
--
V
I
Y
D
A
T
H
S
V
QLPGGLGD
K
S
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
V
G
C
D
G
V
F
M
E
T
H
P
E
P
E
K
A
L
--
S
D
A
S
T
Q
L
P
L
S
Q
L
E
-------------------
49
PsiBlast_CBE
51.48
31%
7
- C2 -
2A2I
4
KDSA_AQUAE
A:
[7-244]
-------------------------------------------------------------------------------------------------------------------------
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
K
F
K
E
V
E
F
V
F
K
S
S
F
D
K
AN
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
N
V
V
E
K
L
K
F
G
G
A
K
E
I
Y
L
T
E
R
G
T
-------
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
A
K
--
V
I
Y
D
A
T
H
S
V
QLPGGLGD
K
S
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
V
G
C
D
G
V
F
M
E
T
H
P
E
P
E
K
A
L
--
S
D
A
S
T
Q
L
P
L
S
Q
L
E
-------------------
58
PsiBlast_CBE
51.35
31%
13
- C2 -
1JCY
4
KDSA_AQUAE
B:
[7-244]
-------------------------------------------------------------------------------------------------------------------------
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
K
F
K
E
V
E
F
V
F
K
S
S
F
D
K
AN
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
N
V
V
E
K
L
K
F
G
G
A
K
E
I
Y
L
T
E
R
G
T
-------
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
A
K
--
V
I
Y
D
A
T
H
S
V
QLPG-------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
V
G
C
D
G
V
F
M
E
T
H
P
E
P
E
K
A
L
--
S
D
A
S
T
Q
L
P
L
S
Q
L
E
-------------------
65
PsiBlast_CBE
51.31
31%
13
- C2 -
1FWT
4
KDSA_AQUAE
B:
[7-244]
-------------------------------------------------------------------------------------------------------------------------
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
K
F
K
E
V
E
F
V
F
K
S
S
F
D
K
AN
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
N
V
V
E
K
L
K
F
G
G
A
K
E
I
Y
L
T
E
R
G
T
-------
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
A
K
--
V
I
Y
D
A
T
H
S
V
QLPG--------
M
R
E
F
I
F
P
L
I
R
A
A
V
A
V
G
C
D
G
V
F
M
E
T
H
P
E
P
E
K
A
L
--
S
D
A
S
T
Q
L
P
L
S
Q
L
E
-------------------
77
PsiBlast_CBE
51.30
31%
8
- C2 -
1T8X
3
KDSA_AQUAE
A:
[7-244]
-------------------------------------------------------------------------------------------------------------------------
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
K
F
K
E
V
E
F
V
F
K
S
S
F
D
K
AN
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
G
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
N
V
V
E
K
L
K
F
G
G
A
K
E
I
Y
L
T
E
R
G
T
-------
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
A
K
--
V
I
Y
D
A
T
H
S
V
QLPGG------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
V
G
C
D
G
V
F
M
E
T
H
P
E
P
E
K
A
L
--
S
D
A
S
T
Q
L
P
L
S
Q
L
E
-------------------
53
PsiBlast_CBE
51.16
31%
5
- C2 -
1PE1
4
KDSA_AQUAE
A:
[7-244]
-------------------------------------------------------------------------------------------------------------------------
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
K
F
K
E
V
E
F
V
F
K
S
S
F
D
K
AN
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
N
V
V
E
K
L
K
F
G
G
A
K
E
I
Y
L
T
E
R
G
T
-------
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
A
K
--
V
I
Y
D
A
T
H
S
V
QLPGG------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
V
G
C
D
G
V
F
M
E
T
H
P
E
P
E
K
A
L
--
S
D
A
S
T
Q
L
P
L
S
Q
L
E
-------------------
61
PsiBlast_CBE
51.14
31%
12
- C2 -
1FXQ
3
KDSA_AQUAE
B:
[7-244]
-------------------------------------------------------------------------------------------------------------------------
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
K
F
K
E
V
E
F
V
F
K
S
S
F
D
K
AN
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
N
V
V
E
K
L
K
F
G
G
A
K
E
I
Y
L
T
E
R
G
T
-------
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
A
K
--
V
I
Y
D
A
T
H
S
V
QLPGGLGD
K
S
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
V
G
C
D
G
V
F
M
E
T
H
P
E
P
E
K
A
L
--
S
D
A
S
T
Q
L
P
L
S
Q
L
E
-------------------
17
PsiBlast_PDB
51.06
31%
12
- C2 -
1FXQ
3
KDSA_AQUAE
A:
[7-244]
-------------------------------------------------------------------------------------------------------------------------
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
K
F
K
E
V
E
F
V
F
K
S
S
F
D
K
AN
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
N
V
V
E
K
L
K
F
G
G
A
K
E
I
Y
L
T
E
R
G
T
-------
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
A
K
--
V
I
Y
D
A
T
H
S
V
QLPGGLGD
K
S
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
V
G
C
D
G
V
F
M
E
T
H
P
E
P
E
K
A
L
--
S
D
A
S
T
Q
L
P
L
S
Q
L
E
-------------------
46
PsiBlast_CBE
50.99
31%
10
- C2 -
3E0I
4
KDSA_AQUAE
B:
[7-244]
-------------------------------------------------------------------------------------------------------------------------
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
K
F
K
E
V
E
F
V
F
K
S
S
F
D
K
AN
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
N
V
V
E
K
L
K
F
G
G
A
K
E
I
Y
L
T
E
R
G
T
-------
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
A
K
--
V
I
Y
D
A
T
H
S
V
QLPG-------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
V
G
C
D
G
V
F
M
E
T
H
P
E
P
E
K
A
L
--
S
D
A
S
T
Q
L
P
L
S
Q
L
E
-------------------
20
PsiBlast_PDB
50.94
31%
9
- C2 -
1JCY
4
KDSA_AQUAE
A:
[7-244]
-------------------------------------------------------------------------------------------------------------------------
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
K
F
K
E
V
E
F
V
F
K
S
S
F
D
K
AN
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
N
V
V
E
K
L
K
F
G
G
A
K
E
I
Y
L
T
E
R
G
T
-------
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
A
K
--
V
I
Y
D
A
T
H
S
V
QLPGGLGD
K
S
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
V
G
C
D
G
V
F
M
E
T
H
P
E
P
E
K
A
L
--
S
D
A
S
T
Q
L
P
L
S
Q
L
E
-------------------
64
PsiBlast_CBE
50.91
31%
14
- C2 -
1FWW
4
KDSA_AQUAE
B:
[7-244]
-------------------------------------------------------------------------------------------------------------------------
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
K
F
K
E
V
E
F
V
F
K
S
S
F
D
K
AN
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
N
V
V
E
K
L
K
F
G
G
A
K
E
I
Y
L
T
E
R
G
T
-------
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
A
K
--
V
I
Y
D
A
T
H
S
V
QLPG-------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
V
G
C
D
G
V
F
M
E
T
H
P
E
P
E
K
A
L
--
S
D
A
S
T
Q
L
P
L
S
Q
L
E
-------------------
74
PsiBlast_CBE
50.78
31%
13
- C2 -
1T96
3
KDSA_AQUAE
B:
[7-244]
-------------------------------------------------------------------------------------------------------------------------
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
K
F
K
E
V
E
F
V
F
K
S
S
F
D
K
AN
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
G
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
N
V
V
E
K
L
K
F
G
G
A
K
E
I
Y
L
T
E
R
G
T
-------
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
A
K
--
V
I
Y
D
A
T
H
S
V
QLPG-------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
V
G
C
D
G
V
F
M
E
T
H
P
E
P
E
K
A
L
--
S
D
A
S
T
Q
L
P
L
S
Q
L
E
-------------------
57
PsiBlast_CBE
50.59
31%
10
- C2 -
1PCK
4
KDSA_AQUAE
A:
[7-244]
-------------------------------------------------------------------------------------------------------------------------
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
K
F
K
E
V
E
F
V
F
K
S
S
F
D
K
AN
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
N
V
V
E
K
L
K
F
G
G
A
K
E
I
Y
L
T
E
R
G
T
-------
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
A
K
--
V
I
Y
D
A
T
H
S
V
QLPGGLG-----
M
R
E
F
I
F
P
L
I
R
A
A
V
A
V
G
C
D
G
V
F
M
E
T
H
P
E
P
E
K
A
L
--
S
D
A
S
T
Q
L
P
L
S
Q
L
E
-------------------
48
PsiBlast_CBE
50.57
31%
15
- C2 -
2A2I
4
KDSA_AQUAE
B:
[7-244]
-------------------------------------------------------------------------------------------------------------------------
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
K
F
K
E
V
E
F
V
F
K
S
S
F
D
K
AN
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
N
V
V
E
K
L
K
F
G
G
A
K
E
I
Y
L
T
E
R
G
T
-------
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
A
K
--
V
I
Y
D
A
T
H
S
V
QLPG-------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
V
G
C
D
G
V
F
M
E
T
H
P
E
P
E
K
A
L
--
S
D
A
S
T
Q
L
P
L
S
Q
L
E
-------------------
11
PsiBlast_PDB
50.57
31%
14
- C2 -
1FWN
3
KDSA_AQUAE
A:
[7-244]
-------------------------------------------------------------------------------------------------------------------------
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
K
F
K
E
V
E
F
V
F
K
S
S
F
D
K
AN
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
N
V
V
E
K
L
K
F
G
G
A
K
E
I
Y
L
T
E
R
G
T
-------
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
A
K
--
V
I
Y
D
A
T
H
S
V
QLPG-------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
V
G
C
D
G
V
F
M
E
T
H
P
E
P
E
K
A
L
--
S
D
A
S
T
Q
L
P
L
S
Q
L
E
-------------------
66
PsiBlast_CBE
50.48
31%
15
- C2 -
1FWS
4
KDSA_AQUAE
B:
[7-244]
-------------------------------------------------------------------------------------------------------------------------
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
LSEKF
K
E
V
E
F
V
F
K
S
S
F
D
K
AN
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
N
V
V
E
K
L
K
F
G
G
A
K
E
I
Y
L
T
E
R
G
T
-------
T
F
G
Y
N
N
L
VV
D
F
R
S
L
P
I
M
K
Q
W
A
K
--
V
I
Y
D
A
T
H
S
V
QLPG-------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
V
G
C
D
G
V
F
M
E
T
H
P
E
P
E
K
A
L
--
S
D
A
S
T
Q
L
P
L
S
Q
L
E
-------------------
12
PsiBlast_PDB
50.42
31%
14
- C2 -
1FWS
4
KDSA_AQUAE
A:
[7-244]
-------------------------------------------------------------------------------------------------------------------------
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
K
F
K
E
V
E
F
V
F
K
S
S
F
D
K
AN
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
N
V
V
E
K
L
K
F
G
G
A
K
E
I
Y
L
T
E
R
G
T
-------
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
A
K
--
V
I
Y
D
A
T
H
S
V
QLPG-------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
V
G
C
D
G
V
F
M
E
T
H
P
E
P
E
K
A
L
--
S
D
A
S
T
Q
L
P
L
S
Q
L
E
-------------------
54
PsiBlast_CBE
50.22
31%
14
- C2 -
1PCW
3
KDSA_AQUAE
B:
[7-244]
-------------------------------------------------------------------------------------------------------------------------
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
K
F
K
E
V
E
F
V
F
K
S
S
F
D
K
AN
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
N
V
V
E
K
L
K
F
G
G
A
K
E
I
Y
L
T
E
R
G
T
-------
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
A
K
--
V
I
Y
D
A
T
H
S
V
QLPG--------
M
R
E
F
I
F
P
L
I
R
A
A
V
A
V
G
C
D
G
V
F
M
E
T
H
P
E
P
E
K
A
L
--
S
D
A
S
T
Q
L
P
L
S
Q
L
E
-------------------
50
PsiBlast_CBE
50.12
31%
13
- C2 -
2A21
4
KDSA_AQUAE
B:
[7-244]
-------------------------------------------------------------------------------------------------------------------------
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
K
F
K
E
V
E
F
V
F
K
S
S
F
D
K
AN
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
N
V
V
E
K
L
K
F
G
G
A
K
E
I
Y
L
T
E
R
G
T
-------
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
A
K
--
V
I
Y
D
A
T
H
S
V
QLPG-------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
V
G
C
D
G
V
F
M
E
T
H
P
E
P
E
K
A
L
--
S
D
A
S
T
Q
L
P
L
S
Q
L
E
-------------------
83
PsiBlast_CBE
49.99
31%
9
- C2 -
1LRQ
4
KDSA_AQUAE
A:
[7-244]
-------------------------------------------------------------------------------------------------------------------------
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
K
F
K
E
V
E
F
V
F
K
S
S
F
D
K
AN
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
N
V
V
E
K
L
K
F
G
G
A
K
E
I
Y
L
T
E
R
G
T
-------
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
A
K
--
V
I
Y
D
A
T
G
S
V
QLPGGLGD
K
S
G
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
V
G
C
D
G
V
F
M
E
T
H
P
E
P
E
K
A
L
--
S
D
A
S
T
Q
L
P
L
S
Q
L
E
-------------------
71
PsiBlast_CBE
49.95
31%
9
- C2 -
1ZHA
3
KDSA_AQUAE
A:
[7-244]
-------------------------------------------------------------------------------------------------------------------------
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
K
F
K
E
V
E
F
V
F
K
S
S
F
D
K
AN
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
G
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
N
V
V
E
K
L
K
F
G
G
A
K
E
I
Y
L
T
E
R
G
T
-------
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
A
K
--
V
I
Y
D
A
T
H
S
V
QLPG-------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
V
G
C
D
G
V
F
M
E
T
H
P
E
P
E
K
A
L
--
S
D
A
S
T
Q
L
P
L
S
Q
L
E
-------------------
67
PsiBlast_CBE
49.79
31%
16
- C2 -
1FWN
3
KDSA_AQUAE
B:
[7-244]
-------------------------------------------------------------------------------------------------------------------------
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
LSEKF
K
E
V
E
F
V
F
K
S
S
F
D
K
AN
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
N
V
V
E
K
L
K
F
G
G
A
K
E
I
Y
L
T
E
R
G
T
-------
T
F
G
Y
N
N
L
VV
D
F
R
S
L
P
I
M
K
Q
W
A
K
--
V
I
Y
D
A
T
H
S
V
QLPG-------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
V
G
C
D
G
V
F
M
E
T
H
P
E
P
E
K
A
L
--
S
D
A
S
T
Q
L
P
L
S
Q
L
E
-------------------
56
PsiBlast_CBE
49.78
31%
12
- C2 -
1PCK
4
KDSA_AQUAE
B:
[7-244]
-------------------------------------------------------------------------------------------------------------------------
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
K
F
K
E
V
E
F
V
F
K
S
S
F
D
K
AN
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
R
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
N
V
V
E
K
L
K
F
G
G
A
K
E
I
Y
L
T
E
R
G
T
-------
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
A
K
--
V
I
Y
D
A
T
H
S
V
QLPG-------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
V
G
C
D
G
V
F
M
E
T
H
P
E
P
E
K
A
L
--
S
D
A
S
T
Q
L
P
L
S
Q
L
E
-------------------
70
PsiBlast_CBE
49.61
31%
15
- C2 -
1ZHA
3
KDSA_AQUAE
B:
[7-244]
-------------------------------------------------------------------------------------------------------------------------
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
K
F
K
E
V
E
F
V
F
K
S
S
F
D
K
AN
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
G
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
N
V
V
E
K
L
K
F
G
G
A
K
E
I
Y
L
T
E
R
G
T
-------
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
A
K
--
V
I
Y
D
A
T
H
S
V
QLPG-------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
V
G
C
D
G
V
F
M
E
T
H
P
E
P
E
K
A
L
--
S
D
A
S
T
Q
L
P
L
S
Q
L
E
-------------------
75
PsiBlast_CBE
49.56
31%
12
- C2 -
1T96
3
KDSA_AQUAE
A:
[7-244]
-------------------------------------------------------------------------------------------------------------------------
I
A
G
P
C
A
I
E
S
E
E
L
L
L
K
V
G
E
E
I
K
R
L
S
E
K
F
K
E
V
E
F
V
F
K
S
S
F
D
K
AN
R
S
S
I
H
S
F
R
G
H
G
L
E
Y
G
V
K
A
L
R
K
V
K
E
E
F
G
L
K
I
T
T
D
I
H
E
S
W
Q
A
E
P
V
A
E
V
A
D
I
I
Q
I
P
A
F
L
C
G
Q
T
D
L
L
L
A
A
A
K
T
G
R
A
V
N
V
K
K
G
Q
F
L
A
P
W
D
T
K
N
V
V
E
K
L
K
F
G
G
A
K
E
I
Y
L
T
E
R
G
T
-------
T
F
G
Y
N
N
L
V
V
D
F
R
S
L
P
I
M
K
Q
W
A
K
--
V
I
Y
D
A
T
H
S
V
QLPG-------
G
M
R
E
F
I
F
P
L
I
R
A
A
V
A
V
G
C
D
G
V
F
M
E
T
H
P
E
P
E
K
A
L
--
S
D
A
S
T
Q
L
P
L
S
Q
L
E
-------------------