@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu30210: (2016-07-19 )
MKIDSWLNDRLDIAKEAGVHRNLRSMNGAPVPERNIDGENQTVWSSNNYLGLASDRRLIDAAQTALQQFGTGSSGSRLTTGNSVWHEKLEKKIASFKRTEAALLFSSGYLANVGVLSSLPEKEDVILSDQLNHASIIDGCRLSKADTVVYRHIDMNDLENKLNETQRYQRRFIVTDGVFSMDGTIVPLDQIISLAKRYHAFVVVDDAHATGVLGDSGRGTSEYFGVYPDIVIGTLSKAVGTEGGFAAGSAVFIDFLLNHARTFIFQTAIPPASCAAAHEAFNIRTSLKNMGYVVKGDHTPIIPVVIGDAHKTVIFAEKLQGKGIYAPAIRPPTVAPGESRIRITITSDHSMGDIDDLLKTFHSIGKELHII
Atome Classification :
(22 SA)
.........10........20..---......30.....-...40..-......50........60........70........80........90........100.......110.......120.......130.......140.......150.......160...--.--...170-.--.......180.......190.......200.......210.......220....---..--.230.........-240........250.......260.......270...----------..------------------..--------280-----------------..--------------------..-------------------....290-...-..--..300.......310.......320.......330.......340.......350.......360.......370
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
I
D
S
W
L
N
D
R
L
D
I
A
K
E
A
G
V
H
R
N
L
---
R
SMNGAPVPERNI-DGEN
Q
T
V
-WSSN
N
Y
L
GLASD
R
R
L
I
D
A
A
Q
T
A
L
Q
QFGTGSSGSRLTTG
N
S
V
W
H
E
K
L
E
K
K
I
A
S
F
KRT
E
A
A
L
L
FSSGYLA
N
V
G
V
L
SSLPEKE
D
V
I
LSDQLNH
A
S
IIDGCRLSKA
D
T
V
V
Y
R
HI
D
M
N
D
L
E
N
K
L
N
E
T
--
Q
--
R
Y
Q
R
R
--
F
--
I
V
TDGVFSMD
G
T
I
V
P
L
D
Q
I
I
S
L
A
K
R
Y
H
A
F
V
V
V
DDAHATGVLGDSGRGTSEYFGV---Y
P
--
D
I
--
V
I
G
T
L
S
K
A
V-GT-EGGFAA
G
S
A
V
F
I
D
F
L
L
N
H
A
R
T
F
I
FQTAIP
P
A
S
C
A
----------
A
A
------------------
H
E
--------
A
F
------------------
N
I
--------------------
R
T
-------------------
S
LKNM
G
Y
-
V
V
K-GD--HT
P
I
I
P
V
V
IGDA
H
K
T
V
I
F
A
E
KLQGKGIYAPAIRPPTVAPGE
S
R
I
R
I
T
I
TSDHSMG
D
I
D
D
L
L
K
T
F
H
S
IGKELHII
8
PsiBlast_PDB
85.35
35%
-76
- C1 -
1DJE
3
BIOF_ECOLI
A:
[45-384]
-------------------------------------------------
S
S
N
D
Y
L
G
L
S
H
H
P
Q
I
I
R
A
W
Q
Q
G
A
E
Q
F
G
I
G
S
G
G
S
G
H
V
S
G
Y
S
V
V
H
Q
A
L
E
E
E
L
A
E
W
L
G
Y
S
R
A
L
L
F
I
S
G
F
A
A
N
Q
A
V
I
A
A
M
M
A
K
E
D
R
I
A
A
D
R
L
S
H
A
S
L
L
E
A
A
S
L
S
P
S
Q
L
R
R
F
A
H
N
D
V
T
H
L
A
R
L
L
A
S
P
--
C
--
P
G
Q
Q
---
M
--
V
V
T
E
G
V
F
S
M
D
G
D
S
A
P
L
A
E
I
Q
Q
V
T
Q
Q
H
N
G
W
L
M
V
D
D
A
H
G
T
G
V
I
G
E
Q
G
R
G
S
C
W
L
Q
K
V
---
K
P
--
E
L
--
L
V
V
T
F
G
K
G
F
-
G
V
-
S
G
A
A
V
L
C
S
S
T
V
A
D
Y
L
L
Q
F
A
R
H
L
I
Y
S
T
S
M
P
P
A
Q
A
Q
----------
A
L
------------------
R
A
--------
S
L
------------------
A
V
I
R
S
D
E
G
D
A
R
R
E
K
L
A
A
L
I
T
R
F
R
A
-------------------
G
V
Q
D
L
P
F
-
T
L
A
-
D
S
--
C
S
A
I
Q
P
L
I
V
G
D
N
S
R
A
L
Q
L
A
E
K
L
R
Q
Q
G
C
W
V
T
G
I
R
P
P
T
V
P
A
G
I
A
R
L
R
L
T
L
T
A
A
H
E
M
Q
D
I
D
R
L
L
E
V
L
H
G
N
G
------
7
PsiBlast_PDB
84.98
35%
-72
- C1 -
1DJ9
3
BIOF_ECOLI
A:
[45-384]
-------------------------------------------------
S
S
N
D
Y
L
G
L
S
H
H
P
Q
I
I
R
A
W
Q
Q
G
A
E
Q
F
G
I
G
S
G
G
S
G
H
V
S
G
Y
S
V
V
H
Q
A
L
E
E
E
L
A
E
W
L
G
Y
S
R
A
L
L
F
I
S
G
F
A
A
N
Q
A
V
I
A
A
M
M
A
K
E
D
R
I
A
A
D
R
L
S
H
A
S
L
L
E
A
A
S
L
S
P
S
Q
L
R
R
F
A
H
N
D
V
T
H
L
A
R
L
L
A
S
P
--
C
--
P
G
Q
Q
---
M
--
V
V
T
E
G
V
F
S
M
D
G
D
S
A
P
L
A
E
I
Q
Q
V
T
Q
Q
H
N
G
W
L
M
V
D
D
A
H
G
T
G
V
I
G
E
Q
G
R
G
S
C
W
L
Q
K
V
---
K
P
--
E
L
--
L
V
V
T
F
G
K
G
F
-
G
V
-
S
G
A
A
V
L
C
S
S
T
V
A
D
Y
L
L
Q
F
A
R
H
L
I
Y
S
T
S
M
P
P
A
Q
A
Q
----------
A
L
------------------
R
A
--------
S
L
------------------
A
V
I
R
S
D
E
G
D
A
R
R
E
K
L
A
A
L
I
T
R
F
R
A
-------------------
G
V
Q
D
L
P
F
-
T
L
A
-
D
S
--
C
S
A
I
Q
P
L
I
V
G
D
N
S
R
A
L
Q
L
A
E
K
L
R
Q
Q
G
C
W
V
T
G
I
R
P
P
T
V
P
A
G
I
A
R
L
R
L
T
L
T
A
A
H
E
M
Q
D
I
D
R
L
L
E
V
L
H
G
N
G
------
5
PsiBlast_PDB
84.60
35%
-67
- C1 -
1BS0
2
BIOF_ECOLI
A:
[45-384]
-------------------------------------------------
S
S
N
D
Y
L
G
L
S
H
H
P
Q
I
I
R
A
W
Q
Q
G
A
E
Q
F
G
I
G
S
G
G
S
G
H
V
S
G
Y
S
V
V
H
Q
A
L
E
E
E
L
A
E
W
L
G
Y
S
R
A
L
L
F
I
S
G
F
A
A
N
Q
A
V
I
A
A
M
M
A
K
E
D
R
I
A
A
D
R
L
S
H
A
S
L
L
E
A
A
S
L
S
P
S
Q
L
R
R
F
A
H
N
D
V
T
H
L
A
R
L
L
A
S
P
--
C
--
P
G
Q
Q
---
M
--
V
V
T
E
G
V
F
S
M
D
G
D
S
A
P
L
A
E
I
Q
Q
V
T
Q
Q
H
N
G
W
L
M
V
D
D
A
H
G
T
G
V
I
G
E
Q
G
R
G
S
C
W
L
Q
K
V
---
K
P
--
E
L
--
L
V
V
T
F
G
K
G
F
-
G
V
-
S
G
A
A
V
L
C
S
S
T
V
A
D
Y
L
L
Q
F
A
R
H
L
I
Y
S
T
S
M
P
P
A
Q
A
Q
----------
A
L
------------------
R
A
--------
S
L
------------------
A
V
I
R
S
D
E
G
D
A
R
R
E
K
L
A
A
L
I
T
R
F
R
A
-------------------
G
V
Q
D
L
P
F
-
T
L
A
-
D
S
--
C
S
A
I
Q
P
L
I
V
G
D
N
S
R
A
L
Q
L
A
E
K
L
R
Q
Q
G
C
W
V
T
A
I
R
P
P
T
V
P
A
G
T
A
R
L
-
L
T
L
T
A
A
H
E
M
Q
D
I
D
R
L
L
E
V
L
H
G
N
G
------
1
PsiBlast_PDB
84.45
36%
-40
- C1 -
3A2B
2
?
A:
[19-392]
--------------
K
A
K
G
L
Y
A
Y
F
---
R
P
I
Q
S
K
Q
D
T
E
V
K
I
-
D
G
R
R
V
L
M
-
F
G
S
N
S
Y
L
G
L
T
T
D
T
R
I
I
K
A
A
Q
D
A
L
E
K
Y
G
T
G
C
A
G
S
R
F
L
N
G
T
L
D
I
H
V
E
L
E
E
K
L
S
A
Y
V
G
K
E
A
A
I
L
F
S
T
G
F
Q
S
N
L
G
P
L
S
C
L
M
G
R
N
D
Y
I
L
L
D
E
R
D
H
A
S
I
I
D
G
S
R
L
S
F
S
K
V
I
K
Y
G
H
N
N
M
E
D
L
R
A
K
L
S
R
L
--
P
--
E
D
S
A
K
--
L
--
I
C
T
D
G
I
F
S
M
E
G
D
I
V
N
L
P
E
L
T
S
I
A
N
E
F
D
A
A
V
M
V
D
D
A
H
S
L
G
V
I
G
H
K
G
A
G
T
A
S
H
F
G
L
---
N
D
--
D
V
D
L
I
M
G
T
F
S
K
S
L
-
A
S
-
L
G
G
F
V
A
G
D
A
D
V
I
D
F
L
K
H
N
A
R
S
V
M
F
S
A
S
M
T
P
A
S
V
A
----------
S
T
------------------
L
K
--------
A
L
------------------
E
I
I
Q
N
E
P
E
H
I
E
K
L
W
K
N
T
D
Y
A
--
K
A
-------------------
Q
L
L
D
H
G
F
-
D
L
G
-
A
T
--
E
S
P
I
L
P
I
F
I
R
S
N
E
K
T
F
W
V
T
K
M
L
Q
D
D
G
V
F
V
N
P
V
V
S
P
A
V
P
A
E
E
S
L
I
R
F
S
L
M
A
T
H
T
Y
D
Q
I
D
E
A
I
E
K
M
V
K
V
F
K
Q
A
---
47
Fugue
84.32
34%
-61
- C1 -
1BS0
3
BIOF_ECOLI
A:
[2-384]
-
S
W
Q
E
K
I
N
A
A
L
D
A
R
R
A
A
D
A
L
R
R
R
---
Y
P
V
A
Q
G
A
G
R
W
L
V
A
-
D
D
R
Q
Y
L
N
-
F
S
S
N
D
Y
L
G
L
S
H
H
P
Q
I
I
R
A
W
Q
Q
G
A
E
Q
F
G
I
G
S
G
G
S
G
H
V
S
G
Y
S
V
V
H
Q
A
L
E
E
E
L
A
E
W
L
G
Y
S
R
A
L
L
F
I
S
G
F
A
A
N
Q
A
V
I
A
A
M
M
A
K
E
D
R
I
A
A
D
R
L
S
H
A
S
L
L
E
A
A
S
L
S
P
S
Q
L
R
R
F
A
H
N
D
V
T
H
L
A
R
L
L
A
S
---
P
--
C
P
G
Q
Q
--
M
--
V
V
T
E
G
V
F
S
M
D
G
D
S
A
P
L
A
E
I
Q
Q
V
T
Q
Q
H
N
G
W
L
M
V
D
D
A
H
G
T
G
V
I
G
E
Q
G
R
G
S
C
W
L
Q
K
V
---
K
P
--
E
L
--
L
V
V
T
F
G
K
G
F
-
G
V
-
S
G
A
A
V
L
C
S
S
T
V
A
D
Y
L
L
Q
F
A
R
H
L
I
Y
S
T
S
M
P
P
A
Q
A
Q
----------
A
L
------------------
R
A
--------
S
L
------------------
A
V
I
R
S
D
E
G
D
A
R
R
E
K
L
A
A
L
I
T
R
F
R
A
-------------------
G
V
Q
D
L
P
F
-
T
L
A
-
D
S
--
C
S
A
I
Q
P
L
I
V
G
D
N
S
R
A
L
Q
L
A
E
K
L
R
Q
Q
G
C
W
V
T
A
I
R
P
P
T
V
P
A
G
T
A
R
L
-
L
T
L
T
A
A
H
E
M
Q
D
I
D
R
L
L
E
V
L
H
G
N
G
------
6
PsiBlast_PDB
83.18
35%
-67
- C1 -
2G6W
1
BIOF_ECOLI
A:
[45-384]
-------------------------------------------------
S
S
N
D
Y
L
G
L
S
H
H
P
Q
I
I
R
A
W
Q
Q
G
A
E
Q
F
G
I
G
S
G
G
S
G
H
V
S
G
Y
S
V
V
H
Q
A
L
E
E
E
L
A
E
W
L
G
Y
S
R
A
L
L
F
I
S
G
F
A
A
N
Q
A
V
I
A
A
M
M
A
K
E
D
R
I
A
A
D
R
L
S
H
A
S
L
L
E
A
A
S
L
S
P
S
Q
L
R
R
F
A
H
N
D
V
T
H
L
A
R
L
L
A
S
P
--
C
--
P
G
Q
Q
---
M
--
V
V
T
E
G
V
F
S
M
D
G
D
S
A
P
L
A
E
I
Q
Q
V
T
Q
Q
H
N
G
W
L
M
V
D
D
A
H
G
T
G
V
I
G
E
Q
G
R
G
S
C
W
L
Q
K
V
---
K
P
--
E
L
--
L
V
V
T
F
G
K
G
F
-
G
V
-
S
G
A
A
V
L
C
S
S
T
V
A
D
Y
L
L
Q
F
A
R
H
L
I
Y
S
T
S
M
P
P
A
Q
A
Q
----------
A
L
------------------
R
A
--------
S
L
------------------
A
V
I
R
S
D
E
G
D
A
R
R
E
K
L
A
A
L
I
T
R
F
R
A
-------------------
G
V
Q
D
L
P
F
-
T
L
A
-
D
S
--
C
S
A
I
Q
P
L
I
V
G
D
N
S
R
A
L
Q
L
A
E
K
L
R
Q
Q
G
C
W
V
T
A
I
R
P
P
T
V
P
A
G
T
A
R
L
R
L
T
L
T
A
A
H
E
M
Q
D
I
D
R
L
L
E
V
L
H
G
N
G
------
4
PsiBlast_PDB
82.88
32%
-61
- C1 -
2X8U
-
?
A:
[39-399]
-----------------------------------
E
A
M
I
-
N
G
R
K
T
I
L
-
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
Q
A
L
D
E
F
G
S
G
T
T
G
S
R
V
L
N
G
T
Y
Q
G
H
K
A
C
E
D
A
L
K
E
F
Y
G
T
E
H
A
I
V
F
S
T
G
Y
Q
A
N
L
G
M
I
S
T
L
A
G
K
G
D
Y
I
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
W
L
G
D
A
E
I
V
R
F
R
H
N
S
V
E
D
L
D
K
R
L
G
R
L
--
P
--
A
E
A
G
K
--
L
--
V
V
L
E
G
V
Y
S
M
M
G
D
I
A
P
L
Q
E
M
V
A
V
S
K
K
H
G
A
M
I
L
V
D
E
A
H
G
M
G
F
F
G
E
H
G
R
G
V
F
E
E
A
G
V
---
E
A
--
D
V
D
F
V
V
G
T
F
S
K
S
V
-
G
T
-
V
G
G
F
C
V
S
N
H
P
K
F
E
V
L
R
L
V
C
R
P
Y
V
F
T
A
S
L
P
P
S
V
V
A
----------
T
A
------------------
A
T
--------
S
I
R
K
L
M
H
A
G
D
K
R
A
H
L
W
K
N
S
R
R
L
--------------------
H
Q
-------------------
G
L
R
D
M
G
Y
-
K
L
G
-
T
E
TA
Q
S
A
I
I
A
V
I
L
T
D
M
A
Q
A
V
A
L
W
Q
G
L
L
E
A
G
L
Y
V
N
T
A
R
P
P
A
T
P
A
G
M
F
L
L
R
C
S
L
C
A
E
H
S
D
E
Q
V
E
Q
I
L
G
M
F
E
S
A
G
R
A
T
G
V
I
17
PsiBlast_PDB
82.51
31%
-72
- C1 -
4BMK
6
?
A:
[80-440]
-----------------------------------
E
A
V
I
-
R
G
K
D
T
I
L
-
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
E
A
L
E
K
F
G
S
G
T
N
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
T
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
G
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
D
K
R
L
G
R
L
--
P
--
K
E
P
A
K
--
L
--
V
V
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
G
R
G
V
Y
E
A
Q
G
L
---
E
G
QI
D
F
--
V
V
G
T
F
S
A
S
V
-
G
T
-
V
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
L
M
T
A
------------------
H
E
K
R
E
R
L
W
S
N
A
R
------------------
A
L
--------------------
H
G
-------------------
G
L
K
A
M
G
F
-
R
L
G
-
T
E
TC
D
S
A
I
V
A
V
M
L
E
D
Q
E
Q
A
A
M
M
W
Q
A
L
L
D
G
G
L
Y
V
N
M
A
R
P
P
A
T
P
A
G
T
F
L
L
R
C
S
I
C
A
E
H
T
P
A
Q
I
Q
T
V
L
G
M
F
Q
A
A
G
R
A
V
G
V
I
10
PsiBlast_PDB
82.10
32%
-65
- C1 -
2W8J
1
?
A:
[58-418]
-----------------------------------
E
A
V
I
-
R
G
K
D
T
I
L
-
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
E
A
L
E
K
F
G
S
G
T
N
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
T
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
G
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
D
K
R
L
G
R
L
--
P
--
K
E
P
A
K
--
L
--
V
V
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
G
R
G
V
Y
E
A
Q
G
L
---
E
G
QI
D
F
--
V
V
G
T
F
S
K
S
V
-
G
T
-
V
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
L
M
T
A
------------------
H
E
K
R
E
R
L
W
S
N
A
R
------------------
A
L
--------------------
H
G
-------------------
G
L
K
A
M
G
F
-
R
L
G
-
T
E
TC
D
S
A
I
V
A
V
M
L
E
D
Q
E
Q
A
A
M
M
W
Q
A
L
L
D
G
G
L
Y
V
N
M
A
R
P
P
A
T
P
A
G
T
F
L
L
R
C
S
I
C
A
E
H
T
P
A
Q
I
Q
T
V
L
G
M
F
Q
A
A
G
R
A
V
G
V
I
63
HHSearch
81.90
35%
-60
- C1 -
3WY7
-
BIOF_MYCS2
A:
[37-381]
--------------------------------------------
E
L
D
-
L
A
S
N
D
Y
L
G
L
S
Q
H
P
D
V
L
D
G
G
V
E
A
L
R
T
W
G
G
G
A
G
G
S
R
L
V
T
G
N
T
E
L
H
E
A
F
E
H
Q
L
A
S
F
L
G
A
E
S
A
L
V
F
S
S
G
Y
T
A
N
L
G
A
L
V
A
L
S
G
P
G
S
L
I
V
S
D
A
L
S
H
A
S
L
V
D
A
C
R
L
S
R
A
R
V
V
V
S
P
H
R
D
V
D
A
V
D
A
A
L
A
A
R
-----
T
E
E
R
A
--
V
--
V
V
T
E
S
V
F
S
A
D
G
D
L
A
P
L
R
D
L
H
A
V
C
R
R
H
G
A
L
L
L
V
D
E
A
H
G
L
G
V
R
G
T
R
G
Q
G
L
L
H
E
V
G
L
AG-
A
P
--
D
I
V
-
M
T
T
T
L
S
K
A
L
-
G
S
-
Q
G
G
A
V
L
G
P
E
A
V
R
A
H
L
I
D
T
A
R
S
F
I
F
D
T
G
L
A
P
A
A
V
G
----------
A
A
------------------
S
A
--------
A
L
------------------
R
V
--------------------
L
D
A
E
P
Q
R
A
R
A
V
L
D
R
A
A
E
----
L
A
T
I
A
G
V
-
T
E
--
A
P
--
V
S
A
V
V
S
V
I
L
G
D
P
E
I
A
V
G
A
A
A
A
C
L
D
R
G
V
R
V
G
C
F
R
P
P
T
V
P
A
G
T
S
R
L
R
L
A
A
R
A
S
L
T
D
D
E
M
A
L
A
R
Q
V
L
T
D
V
L
A
T
A
R
--
11
PsiBlast_PDB
81.67
32%
-65
- C1 -
2XBN
1
?
A:
[58-418]
-----------------------------------
E
A
V
I
-
R
G
K
D
T
I
L
-
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
E
A
L
E
K
F
G
S
G
T
N
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
T
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
G
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
D
K
R
L
G
R
L
--
P
--
K
E
P
A
K
--
L
--
V
V
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
G
R
G
V
Y
E
A
Q
G
L
---
E
G
QI
D
F
--
V
V
G
T
F
S
K
S
V
-
G
T
-
V
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
L
M
T
A
------------------
H
E
K
R
E
R
L
W
S
N
A
R
------------------
A
L
--------------------
H
G
-------------------
G
L
K
A
M
G
F
-
R
L
G
-
T
E
TC
D
S
A
I
V
A
V
M
L
E
D
Q
E
Q
A
A
M
M
W
Q
A
L
L
D
G
G
L
Y
V
N
M
A
R
P
P
A
T
P
A
G
T
F
L
L
R
C
S
I
C
A
E
H
T
P
A
Q
I
Q
T
V
L
G
M
F
Q
A
A
G
R
A
V
G
V
I
16
PsiBlast_PDB
81.26
32%
-65
- C1 -
2W8V
-
?
A:
[59-419]
-----------------------------------
E
A
V
I
-
R
G
K
D
T
I
L
-
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
E
A
L
E
K
F
G
S
G
T
W
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
T
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
G
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
D
K
R
L
G
R
L
--
P
--
K
E
P
A
K
--
L
--
V
V
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
G
R
G
V
Y
E
A
Q
G
L
---
E
G
QI
D
F
--
V
V
G
T
F
S
K
S
V
-
G
T
-
V
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
L
M
T
A
------------------
H
E
K
R
E
R
L
W
S
N
A
R
------------------
A
L
--------------------
H
G
-------------------
G
L
K
A
M
G
F
-
R
L
G
-
T
E
TC
D
S
A
I
V
A
V
M
L
E
D
Q
E
Q
A
A
M
M
W
Q
A
L
L
D
G
G
L
Y
V
N
M
A
R
P
P
A
T
P
A
G
T
F
L
L
R
C
S
I
C
A
E
H
T
P
A
Q
I
Q
T
V
L
G
M
F
Q
A
A
G
R
A
V
G
V
I
14
PsiBlast_PDB
81.15
32%
-66
- C1 -
2W8W
1
?
A:
[58-418]
-----------------------------------
E
A
V
I
-
R
G
K
D
T
I
L
-
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
E
A
L
E
K
F
G
S
G
T
Y
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
T
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
G
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
D
K
R
L
G
R
L
--
P
--
K
E
P
A
K
--
L
--
V
V
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
G
R
G
V
Y
E
A
Q
G
L
---
E
G
QI
D
F
--
V
V
G
T
F
S
K
S
V
-
G
T
-
V
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
L
M
T
A
------------------
H
E
K
R
E
R
L
W
S
N
A
R
------------------
A
L
--------------------
H
G
-------------------
G
L
K
A
M
G
F
-
R
L
G
-
T
E
TC
D
S
A
I
V
A
V
M
L
E
D
Q
E
Q
A
A
M
M
W
Q
A
L
L
D
G
G
L
Y
V
N
M
A
R
P
P
A
T
P
A
G
T
F
L
L
R
C
S
I
C
A
E
H
T
P
A
Q
I
Q
T
V
L
G
M
F
Q
A
A
G
R
A
V
G
V
I
65
HHSearch
80.81
30%
-65
- C- -
4IW7
-
?
A:
[26-371]
-----------------------------------------
D
D
S
I
I
D
-
F
T
T
S
D
Y
L
N
L
S
S
A
H
N
L
K
H
A
I
V
N
G
F
D
K
Y
G
F
G
S
K
--------
T
D
E
T
Q
Q
F
E
H
E
F
A
K
F
I
N
Y
P
R
A
I
F
F
S
S
G
F
M
A
N
L
A
I
Y
S
T
L
F
S
K
H
D
S
I
F
A
D
K
Y
I
H
A
S
I
I
D
G
I
K
L
S
Q
A
K
L
R
R
Y
K
H
Q
Q
L
S
Q
L
Q
D
I
Y
D
---------
G
K
S
--
F
--
I
T
T
E
G
V
F
S
T
S
G
S
I
T
Q
L
D
K
L
A
K
I
T
---
P
E
K
L
I
V
D
E
A
H
S
F
G
V
L
G
K
N
G
R
G
A
I
N
S
F
R
I
SYK
N
C
--
L
I
--
C
V
F
P
L
G
K
A
F
-
G
G
-
V
G
A
V
V
C
T
T
E
A
I
A
E
Y
L
I
Q
F
A
R
N
Y
I
Y
T
T
A
L
P
P
M
I
L
K
----------
A
A
------------------
L
I
--------
Q
L
------------------
K
N
--------------------
L
E
N
V
N
D
N
R
A
R
L
Q
Q
N
I
T
F
F
N
E
-
L
C
D
A
K
D
L
-
E
L
V
S
K
D
--
L
S
P
I
R
S
I
Q
L
N
N
A
N
L
A
I
R
L
K
D
K
L
F
E
N
K
I
I
V
S
-
F
R
Y
P
T
----
Q
A
I
L
R
F
S
L
H
S
N
N
T
F
D
Q
I
Q
Q
A
L
E
I
I
S
K
E
V
K
Y
E
Y
--
15
PsiBlast_PDB
80.68
32%
-67
- C- -
2W8U
-
?
A:
[59-419]
-----------------------------------
E
A
V
I
-
R
G
K
D
T
I
L
-
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
E
A
L
E
K
F
G
S
G
T
Y
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
T
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
G
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
D
K
R
L
G
R
L
--
P
--
K
E
P
A
K
--
L
--
V
V
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
G
R
G
V
Y
E
A
Q
G
L
---
E
G
QI
D
F
--
V
V
G
T
F
S
K
S
V
-
G
T
-
V
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
L
M
T
A
------------------
H
E
K
R
E
R
L
W
S
N
A
R
------------------
A
L
--------------------
H
G
-------------------
G
L
K
A
M
G
F
-
R
L
G
-
T
E
TC
D
S
A
I
V
A
V
M
L
E
D
Q
E
Q
A
A
M
M
W
Q
A
L
L
D
G
G
L
Y
V
N
M
A
R
P
P
A
T
P
A
G
T
F
L
L
R
C
S
I
C
A
E
H
T
P
A
Q
I
Q
T
V
L
G
M
F
Q
A
A
G
R
A
V
G
V
I
62
HHSearch
79.50
38%
-1
- C1 -
1FC4
2
KBL_ECOLI
A:
[9-399]
---
Y
Q
Q
L
T
N
D
L
E
T
A
R
A
E
G
L
F
K
E
E
R
I
I
T
S
A
Q
Q
A
D
I
T
--
V
A
-
D
G
S
H
V
I
N
-
F
C
A
N
N
Y
L
G
L
A
N
H
P
D
L
I
A
A
A
K
A
G
M
D
S
H
G
F
G
M
A
S
V
R
F
I
C
G
T
Q
D
S
H
K
E
L
E
Q
K
L
A
A
F
L
G
M
E
D
A
I
L
Y
S
S
C
F
D
A
N
G
G
L
F
E
T
L
L
G
A
E
D
A
I
I
S
D
A
L
N
H
A
S
I
I
D
G
V
R
L
C
K
A
K
R
Y
R
Y
A
N
N
D
M
Q
E
L
E
A
R
L
K
E
A
--
R
E
A
G
A
R
H
V
--
L
--
I
A
T
D
G
V
F
S
M
D
G
V
I
A
N
L
K
G
V
C
D
L
A
D
K
Y
D
A
L
V
M
V
D
D
S
H
A
V
G
F
V
G
E
N
G
R
G
S
H
E
Y
C
D
V
MG-
R
V
--
D
I
--
I
T
G
T
L
G
K
A
L
-
G
G
A
S
G
G
Y
T
A
A
R
K
E
V
V
E
W
L
R
Q
R
S
R
P
Y
L
F
S
N
S
L
A
P
A
I
V
A
----------
A
S
------------------
I
K
--------
V
L
------------------
E
M
--------------------
V
E
A
G
S
E
L
R
D
R
L
W
A
N
A
R
Q
F
R
E
-
Q
M
S
A
A
G
F
-
T
L
A
-
G
A
--
D
H
A
I
I
P
V
M
L
G
D
A
V
V
A
Q
K
F
A
R
E
L
Q
K
E
G
I
Y
V
T
G
F
F
Y
P
V
V
P
K
G
Q
A
R
I
R
T
Q
M
S
A
A
H
T
P
E
Q
I
T
R
A
V
E
A
F
T
R
I
G
K
Q
L
G
V
-
21
PsiBlast_CBE
79.23
31%
-74
- C1 -
4BMK
4
?
B:
[80-438]
-----------------------------------
E
A
V
I
-
R
G
K
D
T
I
L
-
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
E
A
L
E
K
F
G
S
G
T
N
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
T
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
G
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
D
K
R
L
G
R
L
--
P
--
K
E
P
A
K
--
L
--
V
V
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
G
R
G
V
Y
E
A
Q
G
L
---
E
G
QI
D
F
--
V
V
G
T
F
S
A
S
V
-
G
T
-
V
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
TATTSIRKLM
T
A
------------------
H
E
KRERLWSN
A
R
------------------
A
L
--------------------
H
G
-------------------
G
L
K
A
M
G
F
-
R
L
G
-
T
E
TC
D
S
A
I
V
A
V
M
L
E
D
Q
E
Q
A
A
M
M
W
Q
A
L
L
D
G
G
L
Y
V
N
M
A
----------
L
L
R
C
S
I
C
A
E
H
T
P
A
Q
I
Q
T
V
L
G
M
F
Q
A
A
G
R
A
V
G
--
12
PsiBlast_PDB
79.08
32%
-64
- C- -
2JG2
-
?
A:
[59-419]
-----------------------------------
E
A
V
I
-
R
G
K
D
T
I
L
-
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
E
A
L
E
K
F
G
S
G
T
N
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
T
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
G
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
D
K
R
L
G
R
L
--
P
--
K
E
P
A
K
--
L
--
V
V
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
G
R
G
V
Y
E
A
Q
G
L
---
E
G
QI
D
F
--
V
V
G
T
F
S
K
S
V
-
G
T
-
V
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
L
M
T
A
------------------
H
E
K
R
E
R
L
W
S
N
A
R
------------------
A
L
--------------------
H
G
-------------------
G
L
K
A
M
G
F
-
R
L
G
-
T
E
TC
D
S
A
I
V
A
V
M
L
E
D
Q
E
Q
A
A
M
M
W
Q
A
L
L
D
G
G
L
Y
V
N
M
A
R
P
P
A
T
P
A
G
T
F
L
L
R
C
S
I
C
A
E
H
T
P
A
Q
I
Q
T
V
L
G
M
F
Q
A
A
G
R
A
V
G
V
I
13
PsiBlast_PDB
78.70
32%
-65
- C- -
2W8T
-
?
A:
[59-419]
-----------------------------------
E
A
V
I
-
R
G
K
D
T
I
L
-
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
E
A
L
E
K
F
G
S
G
T
C
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
T
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
G
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
D
K
R
L
G
R
L
--
P
--
K
E
P
A
K
--
L
--
V
V
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
G
R
G
V
Y
E
A
Q
G
L
---
E
G
QI
D
F
--
V
V
G
T
F
S
K
S
V
-
G
T
-
V
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
L
M
T
A
------------------
H
E
K
R
E
R
L
W
S
N
A
R
------------------
A
L
--------------------
H
G
-------------------
G
L
K
A
M
G
F
-
R
L
G
-
T
E
TC
D
S
A
I
V
A
V
M
L
E
D
Q
E
Q
A
A
M
M
W
Q
A
L
L
D
G
G
L
Y
V
N
M
A
R
P
P
A
T
P
A
G
T
F
L
L
R
C
S
I
C
A
E
H
T
P
A
Q
I
Q
T
V
L
G
M
F
Q
A
A
G
R
A
V
G
V
I
57
HHSearch
78.50
39%
6
- C1 -
3TQX
2
?
A:
[5-399]
Q
E
I
L
S
Q
L
N
K
E
I
E
G
L
K
K
A
G
L
Y
K
S
E
R
I
I
T
S
P
Q
N
A
E
I
---
K
V
-
G
E
K
E
V
L
N
-
F
C
A
N
N
Y
L
G
L
A
D
H
P
A
L
I
K
T
A
Q
T
V
V
E
Q
Y
G
F
G
M
A
S
V
R
F
I
C
G
T
Q
T
I
H
K
E
L
E
K
D
I
S
E
F
L
G
T
D
D
T
I
L
Y
S
S
C
F
D
A
N
G
G
L
F
E
T
L
L
G
P
E
D
A
I
I
S
D
E
L
N
H
A
S
I
I
D
G
I
R
L
C
K
A
Q
R
Y
R
Y
K
N
N
A
M
G
D
L
E
A
K
L
K
E
A
D
E
K
--
G
A
R
F
K
--
L
--
I
A
T
D
G
V
F
S
M
D
G
I
I
A
D
L
K
S
I
C
D
L
A
D
K
Y
N
A
L
V
M
V
D
D
S
H
A
V
G
F
I
G
E
N
G
R
G
T
P
E
Y
C
G
V
AD-
R
V
--
D
I
--
L
T
G
T
L
G
K
A
L
-
G
G
A
S
G
G
Y
T
S
G
H
K
E
I
I
E
W
L
R
N
R
S
R
P
Y
L
F
S
N
T
V
A
P
V
I
V
A
----------
T
S
------------------
L
K
--------
V
L
------------------
E
L
--------------------
L
K
T
E
G
P
Q
L
R
K
Q
L
Q
E
N
S
R
Y
F
R
A
G
M
E
K
L
G
F
-
Q
L
V
-
P
G
--
N
H
P
I
I
P
V
M
L
G
D
A
Q
L
A
T
N
M
A
D
H
L
L
Q
E
G
I
Y
V
V
G
F
S
Y
P
V
V
P
M
G
K
A
R
I
R
V
Q
M
S
A
V
H
T
Q
Q
Q
L
D
R
A
I
E
A
F
G
Q
V
G
K
K
L
G
A
I
3
PsiBlast_PDB
78.02
36%
-7
- C1 -
1FC4
2
KBL_ECOLI
A:
[12-400]
------
L
T
N
D
L
E
T
A
R
A
E
G
L
F
K
E
E
---
R
I
I
T
S
A
Q
Q
A
D
I
T
V
A
D
G
S
H
V
I
N
-
F
C
A
N
N
Y
L
G
L
A
N
H
P
D
L
I
A
A
A
K
A
G
M
D
S
H
G
F
G
M
A
S
V
R
F
I
C
G
T
Q
D
S
H
K
E
L
E
Q
K
L
A
A
F
L
G
M
E
D
A
I
L
Y
S
S
C
F
D
A
N
G
G
L
F
E
T
L
L
G
A
E
D
A
I
I
S
D
A
L
N
H
A
S
I
I
D
G
V
R
L
C
K
A
K
R
Y
R
Y
A
N
N
D
M
Q
E
L
E
A
R
L
K
E
A
--
R
--
E
A
G
A
R
H
V
L
--
I
A
T
D
G
V
F
S
M
D
G
V
I
A
N
L
K
G
V
C
D
L
A
D
K
Y
D
A
L
V
M
V
D
D
S
H
A
V
G
F
V
G
E
N
G
R
G
S
H
E
Y
C
D
V
---
M
G
RV
D
I
--
I
T
G
T
L
G
K
A
L
G
G
A
-
S
G
G
Y
T
A
A
R
K
E
V
V
E
W
L
R
Q
R
S
R
P
Y
L
F
S
N
S
L
A
P
A
I
V
A
----------
A
S
I
K
V
L
E
M
V
E
A
G
S
E
L
R
D
R
L
W
A
N
--------
A
R
------------------
Q
F
--------------------
R
E
-------------------
Q
M
S
A
A
G
F
-
T
L
A
-
G
A
--
D
H
A
I
I
P
V
M
L
G
D
A
V
V
A
Q
K
F
A
R
E
L
Q
K
E
G
I
Y
V
T
G
F
F
Y
P
V
V
P
K
G
Q
A
R
I
R
T
Q
M
S
A
A
H
T
P
E
Q
I
T
R
A
V
E
A
F
T
R
I
G
K
Q
L
G
V
I
2
PsiBlast_PDB
74.45
37%
-3
- C1 -
3TQX
2
?
A:
[5-399]
Q
E
I
L
S
Q
L
N
K
E
I
E
G
L
K
K
A
G
L
Y
K
S
E
---
R
I
I
T
S
P
Q
N
A
E
I
K
V
--
G
E
K
E
V
L
N
F
C
A
N
N
Y
L
G
L
A
D
H
P
A
L
I
K
T
A
Q
T
V
V
E
Q
Y
G
F
G
M
A
S
V
R
F
I
C
G
T
Q
T
I
H
K
E
L
E
K
D
I
S
E
F
L
G
T
D
D
T
I
L
Y
S
S
C
F
D
A
N
G
G
L
F
E
T
L
L
G
P
E
D
A
I
I
S
D
E
L
N
H
A
S
I
I
D
G
I
R
L
C
K
A
Q
R
Y
R
Y
K
N
N
A
M
G
D
L
E
A
K
L
K
E
A
--
D
--
E
K
G
A
R
--
F
K
L
I
A
T
D
G
V
F
S
M
D
G
I
I
A
D
L
K
S
I
C
D
L
A
D
K
Y
N
A
L
V
M
V
D
D
S
H
A
V
G
F
I
G
E
N
G
R
G
T
P
E
Y
C
G
V
---
A
D
RV
D
I
--
L
T
G
T
L
G
K
A
L
G
G
A
-
S
G
G
Y
T
S
G
H
K
E
I
I
E
W
L
R
N
R
S
R
P
Y
L
F
S
N
T
V
A
P
V
I
V
A
----------
T
S
------------------
L
K
--------
V
L
------------------
E
L
L
K
T
E
G
P
Q
L
R
K
Q
L
Q
E
N
S
R
Y
F
-
R
A
-------------------
G
M
E
K
L
G
F
Q
L
V
P
-
G
N
--
H
-
P
I
I
P
V
M
L
G
D
A
Q
L
A
T
N
M
A
D
H
L
L
Q
E
G
I
Y
V
V
G
F
S
Y
P
V
V
P
M
G
K
A
R
I
R
V
Q
M
S
A
V
H
T
Q
Q
Q
L
D
R
A
I
E
A
F
G
Q
V
G
K
K
L
G
A
I