@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu30220: (2016-07-19 )
MKIDSWLNERLDRMKEAGVHRNLRSMDGAPVPERNIDGENQTVWSSNNYLGLASDRRLIDAAQTALQQFGTGSSGSRLTTGNSVWHEKLEKKIASFKLTEAALLFSSGYLANVGVLSSLPEKEDVILSDQLNHASMIDGCRLSKADTVVYRHIDMNDLENKLNETQRYQRRFIVTDGVFSMDGTIAPLDQIISLAKRYHAFVVVDDAHATGVLGDSGQGTSEYFGVCPDIVIGTLSKAVGAEGGFAAGSAVFIDFLLNHARTFIFQTAIPPASCAAAHEAFNIIEASREKRQLLFSYISMIRTSLKNMGYVVKGDHTPIIPVVIGDAHKTVLFAEKLQGKGIYAPAIRPPTVAPGESRIRITITSDHSMGDIDHLLQTFHSIGKELHII
Atome Classification :
(25 SA)
.........10........20.---.----.-....-------.30.-...-.-...40--........50........60........70........80........90........100.......110.......120-........130.......140.......150.......160....--...170-.--.......180.......190.......200.......210.......220....---..--.230..-.......-240........250.......260.......270.......280..--...-----.--.290........300.......310..--..--....320....-...330.......340........350.......360.......370.......380.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
I
D
S
W
L
N
E
R
L
D
R
M
K
E
A
G
V
HR
N
---
L
----
R
-SMDG-------APVP-ERN-I-DGEN
Q
--
T
V
WSSN
N
Y
L
GLASD
R
R
L
I
D
A
A
Q
T
A
L
Q
QFGTGSSGSRLTTG
N
S
V
W
H
E
K
L
E
K
K
I
A
S
F
KLT
E
A
A
L
L
FSSGYLA
N
V
G
V
L
SSLPE--KE
D
V
I
LSDQLN
H
A
S
MIDGCRLSKA
D
T
V
V
Y
R
HI
D
M
N
D
L
E
N
K
L
N
E
T
Q
--
R
Y
Q
R
R
--
F
--
I
VTDGVFSMDGTI
A
P
L
D
Q
I
I
S
L
A
K
R
Y
H
A
F
V
V
V
DDAHATGVLGDSGQGT
S
E
Y
FGV---
C
P
--
D
I
--
V
I
-
G
T
L
S
K
A
V-GA-EGGFAA
G
S
A
V
F
I
D
F
L
L
N
H
A
R
T
F
I
FQTAIP
P
A
S
C
A
A
A
H
E
A
F
N
I
I
--
E
A
S
-----
R
--
E
K
-
R
Q
L
L
F
S
Y
I
S
M
I
R
T
S
L
K
NM
G
Y
-
V
V
K--GD--HT
P
I
I
P
V
V
IGD-AH
K
T
V
L
F
A
E
KLQGK-GIYAPAIRPPTVAPGE
S
R
I
R
I
T
I
TSDHSMG
D
I
D
H
L
L
Q
T
F
H
S
I
G
K
ELHII
59
Fugue
87.88
34%
-60
- C1 -
1BS0
3
BIOF_ECOLI
A:
[2-384]
-
S
W
Q
E
K
I
N
A
A
L
D
A
R
R
A
A
D
A
L
R
R
---
R
----
Y
-
P
V
A
Q
-------
G
A
G
R
-
W
L
V
-
A
-
D
D
R
Q
Y
--
L
N
F
S
S
N
D
Y
L
G
L
S
H
H
P
Q
I
I
R
A
W
Q
Q
G
A
E
Q
F
G
I
G
S
G
G
S
G
H
V
S
G
Y
S
V
V
H
Q
A
L
E
E
E
L
A
E
W
L
G
Y
S
R
A
L
L
F
I
S
G
F
A
A
N
Q
A
V
I
A
A
M
M
A
--
K
E
D
R
I
A
A
D
R
L
S
H
A
S
L
L
E
A
A
S
L
S
P
S
Q
L
R
R
F
A
H
N
D
V
T
H
L
A
R
L
L
A
S
-
P
--
C
P
G
Q
Q
--
M
--
V
V
T
E
G
V
F
S
M
D
G
D
S
A
P
L
A
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I
Q
Q
V
T
Q
Q
H
N
G
W
L
M
V
D
D
A
H
G
T
G
V
I
G
E
Q
G
R
G
S
C
W
L
Q
K
V
---
K
P
--
E
L
--
L
V
-
V
T
F
G
K
G
F
-
G
V
-
S
G
A
A
V
L
C
S
S
T
V
A
D
Y
L
L
Q
F
A
R
H
L
I
Y
S
T
S
M
P
P
A
Q
A
Q
A
L
R
A
S
L
A
V
I
R
S
D
E
G
-----
D
--
A
R
-
R
E
K
L
A
A
L
I
T
R
F
R
A
G
V
Q
D
L
P
F
-
T
L
A
--
D
S
--
C
S
A
I
Q
P
L
I
V
G
D
-
N
S
R
A
L
Q
L
A
E
K
L
R
Q
Q
-
G
C
W
V
T
A
I
R
P
P
T
V
P
A
G
T
A
R
L
-
L
T
L
T
A
A
H
E
M
Q
D
I
D
R
L
L
E
V
L
H
G
N
G
------
7
PsiBlast_PDB
87.45
36%
-70
- C1 -
1DJE
3
BIOF_ECOLI
A:
[45-384]
----------------------------------------------------------------
S
S
N
D
Y
L
G
L
S
H
H
P
Q
I
I
R
A
W
Q
Q
G
A
E
Q
F
G
I
G
S
G
G
S
G
H
V
S
G
Y
S
V
V
H
Q
A
L
E
E
E
L
A
E
W
L
G
Y
S
R
A
L
L
F
I
S
G
F
A
A
N
Q
A
V
I
A
A
M
M
A
--
K
E
D
R
I
A
A
D
R
L
S
H
A
S
L
L
E
A
A
S
L
S
P
S
Q
L
R
R
F
A
H
N
D
V
T
H
L
A
R
L
L
A
S
P
C
--
P
G
Q
Q
---
M
--
V
V
T
E
G
V
F
S
M
D
G
D
S
A
P
L
A
E
I
Q
Q
V
T
Q
Q
H
N
G
W
L
M
V
D
D
A
H
G
T
G
V
I
G
E
Q
G
R
G
S
C
W
L
Q
K
V
---
K
P
--
E
L
--
L
V
-
V
T
F
G
K
G
F
-
G
V
-
S
G
A
A
V
L
C
S
S
T
V
A
D
Y
L
L
Q
F
A
R
H
L
I
Y
S
T
S
M
P
P
A
Q
A
Q
A
L
R
A
S
L
A
V
I
--
R
S
D
-----
E
G
D
A
R
-
R
E
K
L
A
A
L
I
T
R
F
R
A
G
V
Q
D
L
P
F
-
T
L
A
--
D
S
--
C
S
A
I
Q
P
L
I
V
G
D
-
N
S
R
A
L
Q
L
A
E
K
L
R
Q
Q
-
G
C
W
V
T
G
I
R
P
P
T
V
P
A
G
I
A
R
L
R
L
T
L
T
A
A
H
E
M
Q
D
I
D
R
L
L
E
V
L
H
G
N
G
------
4
PsiBlast_PDB
87.36
36%
-65
- C1 -
1BS0
2
BIOF_ECOLI
A:
[45-384]
----------------------------------------------------------------
S
S
N
D
Y
L
G
L
S
H
H
P
Q
I
I
R
A
W
Q
Q
G
A
E
Q
F
G
I
G
S
G
G
S
G
H
V
S
G
Y
S
V
V
H
Q
A
L
E
E
E
L
A
E
W
L
G
Y
S
R
A
L
L
F
I
S
G
F
A
A
N
Q
A
V
I
A
A
M
M
A
--
K
E
D
R
I
A
A
D
R
L
S
H
A
S
L
L
E
A
A
S
L
S
P
S
Q
L
R
R
F
A
H
N
D
V
T
H
L
A
R
L
L
A
S
P
C
--
P
G
Q
Q
---
M
--
V
V
T
E
G
V
F
S
M
D
G
D
S
A
P
L
A
E
I
Q
Q
V
T
Q
Q
H
N
G
W
L
M
V
D
D
A
H
G
T
G
V
I
G
E
Q
G
R
G
S
C
W
L
Q
K
V
---
K
P
--
E
L
--
L
V
-
V
T
F
G
K
G
F
-
G
V
-
S
G
A
A
V
L
C
S
S
T
V
A
D
Y
L
L
Q
F
A
R
H
L
I
Y
S
T
S
M
P
P
A
Q
A
Q
A
L
R
A
S
L
A
V
I
--
R
S
D
-----
E
G
D
A
R
-
R
E
K
L
A
A
L
I
T
R
F
R
A
G
V
Q
D
L
P
F
-
T
L
A
--
D
S
--
C
S
A
I
Q
P
L
I
V
G
D
-
N
S
R
A
L
Q
L
A
E
K
L
R
Q
Q
-
G
C
W
V
T
A
I
R
P
P
T
V
P
A
G
T
A
R
L
-
L
T
L
T
A
A
H
E
M
Q
D
I
D
R
L
L
E
V
L
H
G
N
G
------
6
PsiBlast_PDB
85.67
36%
-65
- C1 -
1DJ9
3
BIOF_ECOLI
A:
[45-384]
----------------------------------------------------------------
S
S
N
D
Y
L
G
L
S
H
H
P
Q
I
I
R
A
W
Q
Q
G
A
E
Q
F
G
I
G
S
G
G
S
G
H
V
S
G
Y
S
V
V
H
Q
A
L
E
E
E
L
A
E
W
L
G
Y
S
R
A
L
L
F
I
S
G
F
A
A
N
Q
A
V
I
A
A
M
M
A
--
K
E
D
R
I
A
A
D
R
L
S
H
A
S
L
L
E
A
A
S
L
S
P
S
Q
L
R
R
F
A
H
N
D
V
T
H
L
A
R
L
L
A
S
P
C
--
P
G
Q
Q
---
M
--
V
V
T
E
G
V
F
S
M
D
G
D
S
A
P
L
A
E
I
Q
Q
V
T
Q
Q
H
N
G
W
L
M
V
D
D
A
H
G
T
G
V
I
G
E
Q
G
R
G
S
C
W
L
Q
K
V
---
K
P
--
E
L
--
L
V
-
V
T
F
G
K
G
F
-
G
V
-
S
G
A
A
V
L
C
S
S
T
V
A
D
Y
L
L
Q
F
A
R
H
L
I
Y
S
T
S
M
P
P
A
Q
A
Q
A
L
R
A
S
L
A
V
I
--
R
S
D
-----
E
G
D
A
R
-
R
E
K
L
A
A
L
I
T
R
F
R
A
G
V
Q
D
L
P
F
-
T
L
A
--
D
S
--
C
S
A
I
Q
P
L
I
V
G
D
-
N
S
R
A
L
Q
L
A
E
K
L
R
Q
Q
-
G
C
W
V
T
G
I
R
P
P
T
V
P
A
G
I
A
R
L
R
L
T
L
T
A
A
H
E
M
Q
D
I
D
R
L
L
E
V
L
H
G
N
G
------
1
PsiBlast_PDB
85.10
36%
-42
- C1 -
3A2B
2
?
A:
[15-392]
----------
V
E
E
L
K
A
K
G
L
Y
A
Y
---
F
----
R
-
P
I
Q
S
-------
K
Q
D
T
-
E
V
K
-
I
-
D
G
R
R
V
--
L
M
F
G
S
N
S
Y
L
G
L
T
T
D
T
R
I
I
K
A
A
Q
D
A
L
E
K
Y
G
T
G
C
A
G
S
R
F
L
N
G
T
L
D
I
H
V
E
L
E
E
K
L
S
A
Y
V
G
K
E
A
A
I
L
F
S
T
G
F
Q
S
N
L
G
P
L
S
C
L
M
G
--
R
N
D
Y
I
L
L
D
E
R
D
H
A
S
I
I
D
G
S
R
L
S
F
S
K
V
I
K
Y
G
H
N
N
M
E
D
L
R
A
K
L
S
R
L
P
--
E
D
S
A
K
--
L
--
I
C
T
D
G
I
F
S
M
E
G
D
I
V
N
L
P
E
L
T
S
I
A
N
E
F
D
A
A
V
M
V
D
D
A
H
S
L
G
V
I
G
H
K
G
A
G
T
A
S
H
F
G
L
---
N
D
--
D
V
D
L
I
M
-
G
T
F
S
K
S
L
-
A
S
-
L
G
G
F
V
A
G
D
A
D
V
I
D
F
L
K
H
N
A
R
S
V
M
F
S
A
S
M
T
P
A
S
V
A
S
T
L
K
A
L
E
I
I
--
Q
N
E
-----
P
--
E
H
-
I
E
K
L
W
K
N
T
D
Y
A
K
A
Q
L
L
D
H
G
F
-
D
L
G
--
A
T
--
E
S
P
I
L
P
I
F
I
R
S
-
N
E
K
T
F
W
V
T
K
M
L
Q
D
D
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G
V
F
V
N
P
V
V
S
P
A
V
P
A
E
E
S
L
I
R
F
S
L
M
A
T
H
T
Y
D
Q
I
D
E
A
I
E
K
M
V
K
V
F
K
Q
A
---
5
PsiBlast_PDB
84.06
36%
-64
- C1 -
2G6W
1
BIOF_ECOLI
A:
[45-384]
----------------------------------------------------------------
S
S
N
D
Y
L
G
L
S
H
H
P
Q
I
I
R
A
W
Q
Q
G
A
E
Q
F
G
I
G
S
G
G
S
G
H
V
S
G
Y
S
V
V
H
Q
A
L
E
E
E
L
A
E
W
L
G
Y
S
R
A
L
L
F
I
S
G
F
A
A
N
Q
A
V
I
A
A
M
M
A
--
K
E
D
R
I
A
A
D
R
L
S
H
A
S
L
L
E
A
A
S
L
S
P
S
Q
L
R
R
F
A
H
N
D
V
T
H
L
A
R
L
L
A
S
P
C
--
P
G
Q
Q
---
M
--
V
V
T
E
G
V
F
S
M
D
G
D
S
A
P
L
A
E
I
Q
Q
V
T
Q
Q
H
N
G
W
L
M
V
D
D
A
H
G
T
G
V
I
G
E
Q
G
R
G
S
C
W
L
Q
K
V
---
K
P
--
E
L
--
L
V
-
V
T
F
G
K
G
F
-
G
V
-
S
G
A
A
V
L
C
S
S
T
V
A
D
Y
L
L
Q
F
A
R
H
L
I
Y
S
T
S
M
P
P
A
Q
A
Q
A
L
R
A
S
L
A
V
I
--
R
S
D
-----
E
G
D
A
R
-
R
E
K
L
A
A
L
I
T
R
F
R
A
G
V
Q
D
L
P
F
-
T
L
A
--
D
S
--
C
S
A
I
Q
P
L
I
V
G
D
-
N
S
R
A
L
Q
L
A
E
K
L
R
Q
Q
-
G
C
W
V
T
A
I
R
P
P
T
V
P
A
G
T
A
R
L
R
L
T
L
T
A
A
H
E
M
Q
D
I
D
R
L
L
E
V
L
H
G
N
G
------
2
PsiBlast_PDB
83.24
37%
-23
- C1 -
3TQX
2
?
A:
[5-399]
Q
E
I
L
S
Q
L
N
K
E
I
E
G
L
K
K
A
G
L
Y
K
S
---
E
----
R
-
I
I
T
S
-------
P
Q
N
A
-
E
I
K
-
V
-
G
E
K
E
V
--
L
N
F
C
A
N
N
Y
L
G
L
A
D
H
P
A
L
I
K
T
A
Q
T
V
V
E
Q
Y
G
F
G
M
A
S
V
R
F
I
C
G
T
Q
T
I
H
K
E
L
E
K
D
I
S
E
F
L
G
T
D
D
T
I
L
Y
S
S
C
F
D
A
N
G
G
L
F
E
T
L
L
G
--
P
E
D
A
I
I
S
D
E
L
N
H
A
S
I
I
D
G
I
R
L
C
K
A
Q
R
Y
R
Y
K
N
N
A
M
G
D
L
E
A
K
L
K
E
A
D
--
E
K
G
A
R
--
F
K
L
I
A
T
D
G
V
F
S
M
D
G
I
I
A
D
L
K
S
I
C
D
L
A
D
K
Y
N
A
L
V
M
V
D
D
S
H
A
V
G
F
I
G
E
N
G
R
G
T
P
E
Y
C
G
V
---
A
D
RV
D
I
--
L
T
-
G
T
L
G
K
A
L
G
G
A
-
S
G
G
Y
T
S
G
H
K
E
I
I
E
W
L
R
N
R
S
R
P
Y
L
F
S
N
T
V
A
P
V
I
V
A
T
S
L
K
V
L
E
L
L
--
K
T
E
-----
G
--
P
Q
L
R
K
Q
L
Q
E
N
S
R
Y
F
R
A
G
M
E
K
L
G
F
Q
L
V
P
--
G
N
--
H
-
P
I
I
P
V
M
L
G
D
-
A
Q
L
A
T
N
M
A
D
H
L
L
Q
E
-
G
I
Y
V
V
G
F
S
Y
P
V
V
P
M
G
K
A
R
I
R
V
Q
M
S
A
V
H
T
Q
Q
Q
L
D
R
A
I
E
A
F
G
Q
V
G
K
K
L
G
A
I
45
HHSearch
82.15
35%
-60
- C1 -
3WY7
-
BIOF_MYCS2
A:
[37-381]
----------------------------------------------------------
E
--
L
D
L
A
S
N
D
Y
L
G
L
S
Q
H
P
D
V
L
D
G
G
V
E
A
L
R
T
W
G
G
G
A
G
G
S
R
L
V
T
G
N
T
E
L
H
E
A
F
E
H
Q
L
A
S
F
L
G
A
E
S
A
L
V
F
S
S
G
Y
T
A
N
L
G
A
L
V
A
L
S
G
--
P
G
S
L
I
V
S
D
A
L
S
H
A
S
L
V
D
A
C
R
L
S
R
A
R
V
V
V
S
P
H
R
D
V
D
A
V
D
A
A
L
A
A
R
---
T
E
E
R
A
--
V
--
V
V
T
E
S
V
F
S
A
D
G
D
L
A
P
L
R
D
L
H
A
V
C
R
R
H
G
A
L
L
L
V
D
E
A
H
G
L
G
V
R
G
T
R
G
Q
G
L
L
H
E
V
G
L
AG-
A
P
--
D
I
V
-
M
T
-
T
T
L
S
K
A
L
-
G
S
-
Q
G
G
A
V
L
G
P
E
A
V
R
A
H
L
I
D
T
A
R
S
F
I
F
D
T
G
L
A
P
A
A
V
G
A
A
S
A
A
L
R
V
L
--
D
A
----------
E
-
P
Q
R
A
R
A
V
L
D
R
A
A
E
L
A
T
I
A
G
V
-
T
E
A
---
P
--
V
S
A
V
V
S
V
I
L
G
D
-
P
E
I
A
V
G
A
A
A
A
C
L
D
R
-
G
V
R
V
G
C
F
R
P
P
T
V
P
A
G
T
S
R
L
R
L
A
A
R
A
S
L
T
D
D
E
M
A
L
A
R
Q
V
L
T
D
V
L
A
T
A
R
--
43
HHSearch
81.48
38%
8
- C1 -
1FC4
2
KBL_ECOLI
A:
[12-399]
------
L
T
N
D
L
E
T
A
R
A
E
G
L
F
K
E
E
R
I
I
----
T
-
S
A
Q
Q
-------
A
D
I
T
---
V
-
A
-
D
G
S
H
V
--
I
N
F
C
A
N
N
Y
L
G
L
A
N
H
P
D
L
I
A
A
A
K
A
G
M
D
S
H
G
F
G
M
A
S
V
R
F
I
C
G
T
Q
D
S
H
K
E
L
E
Q
K
L
A
A
F
L
G
M
E
D
A
I
L
Y
S
S
C
F
D
A
N
G
G
L
F
E
T
L
L
G
--
A
E
D
A
I
I
S
D
A
L
N
H
A
S
I
I
D
G
V
R
L
C
K
A
K
R
Y
R
Y
A
N
N
D
M
Q
E
L
E
A
R
L
K
E
A
R
E
A
G
A
R
H
V
--
L
--
I
A
T
D
G
V
F
S
M
D
G
V
I
A
N
L
K
G
V
C
D
L
A
D
K
Y
D
A
L
V
M
V
D
D
S
H
A
V
G
F
V
G
E
N
G
R
G
S
H
E
Y
C
D
V
MG-
R
V
--
D
I
--
I
T
-
G
T
L
G
K
A
L
-
G
G
A
S
G
G
Y
T
A
A
R
K
E
V
V
E
W
L
R
Q
R
S
R
P
Y
L
F
S
N
S
L
A
P
A
I
V
A
A
S
I
K
V
L
E
M
V
--
E
A
G
-----
S
--
E
L
-
R
D
R
L
W
A
N
A
R
Q
F
R
E
Q
M
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A
A
G
F
-
T
L
A
--
G
A
--
D
H
A
I
I
P
V
M
L
G
D
-
A
V
V
A
Q
K
F
A
R
E
L
Q
K
E
-
G
I
Y
V
T
G
F
F
Y
P
V
V
P
K
G
Q
A
R
I
R
T
Q
M
S
A
A
H
T
P
E
Q
I
T
R
A
V
E
A
F
T
R
I
G
K
Q
L
G
V
-
44
HHSearch
81.40
28%
-71
- C- -
4IW7
-
?
A:
[26-371]
-------------------------------------------------------
D
D
S
I
--
I
D
F
T
T
S
D
Y
L
N
L
S
S
A
H
N
L
K
H
A
I
V
N
G
F
D
K
Y
G
F
G
S
K
--------
T
D
E
T
Q
Q
F
E
H
E
F
A
K
F
I
N
Y
P
R
A
I
F
F
S
S
G
F
M
A
N
L
A
I
Y
S
T
L
F
S
--
K
H
D
S
I
F
A
D
K
Y
I
H
A
S
I
I
D
G
I
K
L
S
Q
A
K
L
R
R
Y
K
H
Q
Q
L
S
Q
L
Q
D
I
Y
D
-------
G
K
S
--
F
--
I
T
T
E
G
V
F
S
T
S
G
S
I
T
Q
L
D
K
L
A
K
I
T
---
P
E
K
L
I
V
D
E
A
H
S
F
G
V
L
G
K
N
G
R
G
A
I
N
S
F
R
I
SYK
N
C
--
L
I
--
C
V
-
F
P
L
G
K
A
F
-
G
G
-
V
G
A
V
V
C
T
T
E
A
I
A
E
Y
L
I
Q
F
A
R
N
Y
I
Y
T
T
A
L
P
P
M
I
L
K
A
A
L
I
Q
L
K
N
L
--
E
N
V
-----
N
--
D
N
-
R
A
R
L
Q
Q
N
I
T
F
F
N
E
L
C
D
A
K
D
L
-
E
L
V
S-
K
D
--
L
S
P
I
R
S
I
Q
L
N
N
-
A
N
L
A
I
R
L
K
D
K
L
F
E
N
-
K
I
I
V
S
-
F
R
Y
P
T
----
Q
A
I
L
R
F
S
L
H
S
N
N
T
F
D
Q
I
Q
Q
A
L
E
I
I
S
K
E
V
K
Y
E
Y
--
3
PsiBlast_PDB
80.78
37%
-1
- C1 -
1FC4
2
KBL_ECOLI
A:
[12-400]
------
L
T
N
D
L
E
T
A
R
A
E
G
L
F
K
E
---
E
----
R
-
I
I
T
S
-------
A
Q
Q
A
-
D
I
T
-
V
A
D
G
S
H
V
--
I
N
F
C
A
N
N
Y
L
G
L
A
N
H
P
D
L
I
A
A
A
K
A
G
M
D
S
H
G
F
G
M
A
S
V
R
F
I
C
G
T
Q
D
S
H
K
E
L
E
Q
K
L
A
A
F
L
G
M
E
D
A
I
L
Y
S
S
C
F
D
A
N
G
G
L
F
E
T
L
L
G
--
A
E
D
A
I
I
S
D
A
L
N
H
A
S
I
I
D
G
V
R
L
C
K
A
K
R
Y
R
Y
A
N
N
D
M
Q
E
L
E
A
R
L
K
E
A
R
--
E
A
G
A
R
H
V
L
--
I
A
T
D
G
V
F
S
M
D
G
V
I
A
N
L
K
G
V
C
D
L
A
D
K
Y
D
A
L
V
M
V
D
D
S
H
A
V
G
F
V
G
E
N
G
R
G
S
H
E
Y
C
D
V
---
M
G
RV
D
I
--
I
T
-
G
T
L
G
K
A
L
G
G
A
-
S
G
G
Y
T
A
A
R
K
E
V
V
E
W
L
R
Q
R
S
R
P
Y
L
F
S
N
S
L
A
P
A
I
V
A
A
S
I
K
V
L
E
M
V
--
E
A
G
-----
S
--
E
L
-
R
D
R
L
W
A
N
A
R
Q
F
R
E
Q
M
S
A
A
G
F
-
T
L
A
--
G
A
--
D
H
A
I
I
P
V
M
L
G
D
-
A
V
V
A
Q
K
F
A
R
E
L
Q
K
E
-
G
I
Y
V
T
G
F
F
Y
P
V
V
P
K
G
Q
A
R
I
R
T
Q
M
S
A
A
H
T
P
E
Q
I
T
R
A
V
E
A
F
T
R
I
G
K
Q
L
G
V
I
8
PsiBlast_PDB
79.14
33%
-18
- C1 -
2X8U
-
?
A:
[31-399]
---------------------------------
M
D
K
-------
V
L
S
P
T
E
A
M
-
I
-
N
G
R
K
T
--
I
L
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
Q
A
L
D
E
F
G
S
G
T
T
G
S
R
V
L
N
G
T
Y
Q
G
H
K
A
C
E
D
A
L
K
E
F
Y
G
T
E
H
A
I
V
F
S
T
G
Y
Q
A
N
L
G
M
I
S
T
L
A
G
--
K
G
D
Y
I
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
W
L
G
D
A
E
I
V
R
F
R
H
N
S
V
E
D
L
D
K
R
L
G
R
L
P
--
A
E
A
G
K
--
L
--
V
V
L
E
G
V
Y
S
M
M
G
D
I
A
P
L
Q
E
M
V
A
V
S
K
K
H
G
A
M
I
L
V
D
E
A
H
G
M
G
F
F
G
E
H
G
R
G
V
F
E
E
A
G
V
---
E
A
--
D
V
D
F
V
V
-
G
T
F
S
K
S
V
-
G
T
-
V
G
G
F
C
V
S
N
H
P
K
F
E
V
L
R
L
V
C
R
P
Y
V
F
T
A
S
L
P
P
S
V
V
A
T
A
A
T
S
I
R
K
L
--
M
H
A
-----
G
--
D
K
-
R
A
H
L
W
K
N
S
R
R
L
H
Q
G
L
R
D
M
G
Y
-
K
L
G
--
T
E
TA
Q
S
A
I
I
A
V
I
L
T
D
-
M
A
Q
A
V
A
L
W
Q
G
L
L
E
A
-
G
L
Y
V
N
T
A
R
P
P
A
T
P
A
G
M
F
L
L
R
C
S
L
C
A
E
H
S
D
E
Q
V
E
Q
I
L
G
M
F
E
S
A
G
R
A
T
G
V
I
38
HHSearch
78.69
38%
12
- C1 -
3TQX
2
?
A:
[5-399]
Q
E
I
L
S
Q
L
N
K
E
I
E
G
L
K
K
A
G
L
Y
K
S
E
R
I
I
----
T
-
S
P
Q
N
-------
A
E
I
----
K
-
V
-
G
E
K
E
V
--
L
N
F
C
A
N
N
Y
L
G
L
A
D
H
P
A
L
I
K
T
A
Q
T
V
V
E
Q
Y
G
F
G
M
A
S
V
R
F
I
C
G
T
Q
T
I
H
K
E
L
E
K
D
I
S
E
F
L
G
T
D
D
T
I
L
Y
S
S
C
F
D
A
N
G
G
L
F
E
T
L
L
G
--
P
E
D
A
I
I
S
D
E
L
N
H
A
S
I
I
D
G
I
R
L
C
K
A
Q
R
Y
R
Y
K
N
N
A
M
G
D
L
E
A
K
L
K
E
A
D
E
K
G
A
R
F
K
--
L
--
I
A
T
D
G
V
F
S
M
D
G
I
I
A
D
L
K
S
I
C
D
L
A
D
K
Y
N
A
L
V
M
V
D
D
S
H
A
V
G
F
I
G
E
N
G
R
G
T
P
E
Y
C
G
V
AD-
R
V
--
D
I
--
L
T
-
G
T
L
G
K
A
L
-
G
G
A
S
G
G
Y
T
S
G
H
K
E
I
I
E
W
L
R
N
R
S
R
P
Y
L
F
S
N
T
V
A
P
V
I
V
A
T
S
L
K
V
L
E
L
L
--
K
T
E
-----
G
P
-
Q
L
-
R
K
Q
L
Q
E
N
S
R
Y
F
R
A
G
M
E
K
L
G
F
-
Q
L
V
--
P
G
--
N
H
P
I
I
P
V
M
L
G
D
-
A
Q
L
A
T
N
M
A
D
H
L
L
Q
E
-
G
I
Y
V
V
G
F
S
Y
P
V
V
P
M
G
K
A
R
I
R
V
Q
M
S
A
V
H
T
Q
Q
Q
L
D
R
A
I
E
A
F
G
Q
V
G
K
K
L
G
A
I
39
HHSearch
78.46
31%
-65
- C- -
2W8T
-
?
A:
[51-417]
-------------------------
M
----
E
-
Q
V
K
S
-------
P
T
E
A
---
V
-
I
-
R
G
K
D
T
--
I
L
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
E
A
L
E
K
F
G
S
G
T
C
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
T
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
G
--
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
D
K
R
L
G
R
L
P
--
K
E
P
A
K
--
L
--
V
V
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
G
R
G
V
Y
E
A
Q
G
L
EG-
Q
I
--
D
F
--
V
V
-
G
T
F
S
K
S
V
-
G
T
-
V
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
L
--
M
T
A
-----
H
--
E
K
-
R
E
R
L
W
S
N
A
R
A
L
H
G
G
L
K
A
M
G
F
-
R
L
G
TE
T
C
--
D
S
A
I
V
A
V
M
L
E
D
-
Q
E
Q
A
A
M
M
W
Q
A
L
L
D
G
-
G
L
Y
V
N
M
A
R
P
P
A
T
P
A
G
T
F
L
L
R
C
S
I
C
A
E
H
T
P
A
Q
I
Q
T
V
L
G
M
F
Q
A
A
G
R
A
V
G
--
60
Fugue
76.19
32%
-4
- C1 -
2BWN
4
HEM1_RHOCB
A:
[2-397]
-
D
Y
N
L
A
L
D
K
A
I
Q
K
L
H
D
E
G
R
Y
R
T
---
F
----
I
-
D
I
E
R
EKGAFP
K
A
Q
W
N
-
R
P
D
-
G
-
G
K
Q
D
I
--
T
V
W
C
G
N
D
Y
L
G
M
G
Q
H
P
V
V
L
A
A
M
H
E
A
L
E
A
V
G
A
G
S
G
G
T
R
N
I
S
G
T
T
A
Y
H
R
R
L
E
A
E
I
A
G
L
H
Q
K
E
A
A
L
V
F
S
S
A
Y
N
A
N
D
A
T
L
S
T
L
R
V
L
F
P
G
L
I
I
Y
S
D
S
L
N
H
A
S
M
I
E
G
I
K
R
N
A
G
P
K
R
I
F
R
H
N
D
V
A
H
L
R
E
L
I
A
A
D
D
--
P
A
A
P
K
--
L
--
I
A
F
E
S
V
Y
S
M
D
G
D
F
G
P
I
K
E
I
C
D
I
A
E
E
F
G
A
L
T
Y
I
D
E
V
H
A
V
G
M
Y
G
P
R
G
A
G
V
A
E
R
D
G
L
---
M
H
RI
D
I
--
F
N
-
G
T
L
A
K
A
Y
-
G
V
-
F
G
G
Y
I
A
A
S
A
R
M
V
D
A
V
R
S
Y
A
P
G
F
I
F
S
T
S
L
P
P
A
I
A
A
G
A
Q
A
S
I
A
F
L
K
T
A
E
G
-----
Q
--
K
L
-
R
D
A
Q
Q
M
H
A
K
V
L
K
M
R
L
K
A
L
G
M
-
P
I
I
--
D
H
--
G
S
H
I
V
P
V
V
I
G
D
-
P
V
H
T
K
A
V
S
D
M
L
L
S
D
Y
G
V
Y
V
Q
P
I
N
F
P
T
V
P
R
G
T
E
R
L
R
F
T
P
S
P
V
H
D
L
K
Q
I
D
G
L
V
H
A
M
D
L
L
W
------
18
PsiBlast_PDB
76.10
36%
-66
- C1 -
3WY7
-
BIOF_MYCS2
A:
[37-355]
--------------------------------------------------
E
-
L
-
D
--------
L
A
S
N
D
Y
L
G
L
S
Q
H
P
D
V
L
D
G
G
V
E
A
L
R
T
W
G
G
G
A
G
G
S
R
L
V
T
G
N
T
E
L
H
E
A
F
E
H
Q
L
A
S
F
L
G
A
E
S
A
L
V
F
S
S
G
Y
T
A
N
L
G
A
L
V
A
L
S
G
--
P
G
S
L
I
V
S
D
A
L
S
H
A
S
L
V
D
A
C
R
L
S
R
A
R
V
V
V
S
P
H
-
R
D
V
D
A
V
D
A
A
L
A
A
R
--
T
E
E
R
A
--
V
--
V
V
T
E
S
V
F
S
A
D
G
D
L
A
P
L
R
D
L
H
A
V
C
R
R
H
G
A
L
L
L
V
D
E
A
H
G
L
G
V
R
G
T
R
G
Q
G
L
L
H
E
V
G
L
AG-
A
P
--
D
I
--
V
M
T
T
T
L
S
K
A
L
-
G
S
-
Q
G
G
A
V
L
G
P
E
A
V
R
A
H
L
I
D
T
A
R
S
F
I
F
D
T
G
L
A
P
A
A
V
G
A
A
S
A
A
L
R
V
L
--
D
A
E
-----
P
--
Q
R
-
A
R
A
V
L
D
R
A
A
----
E
L
A
T
I
A
G
-
V
T
E
--
A
P
--
V
S
A
V
V
S
V
I
L
G
D
-
P
E
I
A
V
G
A
A
A
A
C
L
D
R
-
G
V
R
V
G
C
F
R
P
P
T
V
P
A
G
T
S
R
L
R
L
----------------------------
42
HHSearch
75.70
35%
-7
* C1 *
1BS0
3
BIOF_ECOLI
A:
[7-383]
------
I
N
A
A
L
D
A
R
R
A
A
D
A
L
R
R
R
Y
P
V
----
A
-
Q
G
A
G
-------
R
W
L
V
---
A
---
D
D
R
Q
Y
--
L
N
F
S
S
N
D
Y
L
G
L
S
H
H
P
Q
I
I
R
A
W
Q
Q
G
A
E
Q
F
G
I
G
S
G
G
S
G
H
V
S
G
Y
S
V
V
H
Q
A
L
E
E
E
L
A
E
W
L
G
Y
S
R
A
L
L
F
I
S
G
F
A
A
N
Q
A
V
I
A
A
M
M
A
--
K
E
D
R
I
A
A
D
R
L
S
H
A
S
L
L
E
A
A
S
L
S
P
S
Q
L
R
R
F
A
H
N
D
V
T
H
L
A
R
L
L
A
S
P
---
C
P
G
Q
Q
--
M
--
V
V
T
E
G
V
F
S
M
D
G
D
S
A
P
L
A
E
I
Q
Q
V
T
Q
Q
H
N
G
W
L
M
V
D
D
A
H
G
T
G
V
I
G
E
Q
G
R
G
S
C
W
L
Q
K
V
---
K
P
--
E
L
--
L
V
-
V
T
F
G
K
G
F
-
G
V
-
S
G
A
A
V
L
C
S
S
T
V
A
D
Y
L
L
Q
F
A
R
H
L
I
Y
S
T
S
M
P
P
A
Q
A
Q
A
L
R
A
S
L
A
V
I
--
R
S
D
-----
E
G
D
A
R
-
R
E
K
L
A
A
L
I
T
R
F
R
A
G
V
Q
D
L
P
F
-
T
L
A
--
D
S
--
C
S
A
I
Q
P
L
I
V
G
D
-
N
S
R
A
L
Q
L
A
E
K
L
R
Q
Q
-
G
C
W
V
T
A
I
R
P
P
T
V
P
A
G
T
A
R
L
-
L
T
L
T
A
A
H
E
M
Q
D
I
D
R
L
L
E
V
L
H
G
N
-------
29
PsiBlast_CBE
75.66
32%
-4
- C1 -
2BWN
3
HEM1_RHOCB
D:
[1-393]
M
D
Y
N
L
A
L
D
K
A
I
Q
K
L
H
D
E
G
R
Y
R
T
---
F
IDIE
R
-
E
K
G
A
-------
F
P
K
A
-
Q
W
N
R
P
-
D
G
G
K
Q
DI
T
V
W
C
G
N
D
Y
L
G
M
G
Q
H
P
V
V
L
A
A
M
H
E
A
L
E
A
V
G
A
G
S
G
G
T
R
N
I
S
G
T
T
A
Y
H
R
R
L
E
A
E
I
A
G
L
H
Q
K
E
A
A
L
V
F
S
S
A
Y
N
A
N
D
A
T
L
S
T
L
R
V
LF
P
G
L
I
I
Y
S
D
S
L
N
H
A
S
M
I
E
G
I
K
R
N
A
G
P
K
R
I
F
R
H
N
D
V
A
H
L
R
E
L
I
A
A
D
D
--
P
A
A
P
K
--
L
--
I
A
F
E
S
V
Y
S
M
D
G
D
F
G
P
I
K
E
I
C
D
I
A
E
E
F
G
A
L
T
Y
I
D
E
V
H
A
V
G
M
Y
G
P
R
G
A
G
V
A
E
R
D
G
L
---
M
H
RI
D
I
--
F
N
-
G
T
L
A
K
A
Y
-
G
V
-
F
G
G
Y
I
A
A
S
A
R
M
V
D
A
V
R
S
Y
A
P
G
F
I
F
S
T
S
L
P
P
A
I
A
A
G
A
Q
A
S
I
A
F
L
--
K
T
A
EGQKL
R
--
D
A
-
Q
Q
M
---
H
A
K
V
L
K
M
R
L
K
A
L
G
M
-
P
I
I
--
D
H
--
G
S
H
I
V
P
V
V
I
G
D
P
V
H
T
K
A
V
S
D
M
L
L
S
D
Y
-
G
V
Y
V
Q
P
I
N
F
P
T
V
P
R
G
T
E
R
L
R
F
T
P
S
P
V
H
D
L
K
Q
I
D
G
L
V
H
A
M
----------
30
PsiBlast_CBE
75.48
32%
-2
- C1 -
2BWN
2
HEM1_RHOCB
B:
[1-393]
M
D
Y
N
L
A
L
D
K
A
I
Q
K
L
H
D
E
G
R
Y
R
T
---
F
I
D
I
E
R
-
E
K
G
A
-------
F
P
K
A
-
Q
W
N
R
P
-
D
G
G
K
Q
D
I
T
V
W
C
G
N
D
Y
L
G
M
G
Q
H
P
V
V
L
A
A
M
H
E
A
L
E
A
V
G
A
G
S
G
G
T
R
N
I
S
G
T
T
A
Y
H
R
R
L
E
A
E
I
A
G
L
H
Q
K
E
A
A
L
V
F
S
S
A
Y
N
A
N
D
A
T
L
S
T
L
R
V
L
F
P
G
L
I
I
Y
S
D
S
L
N
H
A
S
M
I
E
G
I
K
R
N
A
G
P
K
R
I
F
R
H
N
D
V
A
H
L
R
E
L
I
A
A
D
D
--
P
A
A
P
K
--
L
--
I
A
F
E
S
V
Y
S
M
D
G
D
F
G
P
I
K
E
I
C
D
I
A
E
E
F
G
A
L
T
Y
I
D
E
V
H
A
V
G
M
Y
G
P
R
G
A
G
V
A
E
R
D
G
L
---
M
H
RI
D
I
--
F
N
-
G
T
L
A
K
A
Y
-
G
V
-
F
G
G
Y
I
A
A
S
A
R
M
V
D
A
V
R
S
Y
A
P
G
F
I
F
S
T
S
L
P
P
A
I
A
A
G
A
Q
A
S
I
A
F
L
--
K
T
A
E
G
Q
K
L
R
--
D
A
-
Q
Q
M
---
H
A
K
V
L
K
M
R
L
K
A
L
G
M
-
P
I
I
--
D
H
--
G
S
H
I
V
P
V
V
I
G
D
P
V
H
T
K
A
V
S
D
M
L
L
S
D
Y
-
G
V
Y
V
Q
P
I
N
F
P
T
V
P
R
G
T
E
R
L
R
F
T
P
S
P
V
H
D
L
K
Q
I
D
G
L
V
H
A
M
----------
17
PsiBlast_PDB
75.33
31%
-0
- C1 -
4BMK
6
?
A:
[48-440]
-
K
F
D
G
L
I
A
E
R
-
Q
K
L
L
D
S
G
V
T
D
P
---
F
----
A
I
V
M
E
Q
-------
V
K
S
P
T
E
A
V
-
I
-
R
G
K
D
T
--
I
L
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
E
A
L
E
K
F
G
S
G
T
N
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
T
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
G
--
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
D
K
R
L
G
R
L
P
--
K
E
P
A
K
--
L
--
V
V
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
G
R
G
V
Y
E
A
Q
G
L
---
E
G
QI
D
F
--
V
V
-
G
T
F
S
A
S
V
-
G
T
-
V
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
L
--
M
T
A
-----
H
--
E
K
-
R
E
R
L
W
S
N
A
R
A
L
H
G
G
L
K
A
M
G
F
-
R
L
G
--
T
E
TC
D
S
A
I
V
A
V
M
L
E
D
-
Q
E
Q
A
A
M
M
W
Q
A
L
L
D
G
-
G
L
Y
V
N
M
A
R
P
P
A
T
P
A
G
T
F
L
L
R
C
S
I
C
A
E
H
T
P
A
Q
I
Q
T
V
L
G
M
F
Q
A
A
G
R
A
V
G
V
I
10
PsiBlast_PDB
74.99
31%
4
- C1 -
2W8J
1
?
A:
[26-418]
-
K
F
D
G
L
I
A
E
R
-
Q
K
L
L
D
S
G
V
T
D
P
---
F
----
A
I
V
M
E
Q
-------
V
K
S
P
T
E
A
V
-
I
-
R
G
K
D
T
--
I
L
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
E
A
L
E
K
F
G
S
G
T
N
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
T
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
G
--
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
D
K
R
L
G
R
L
P
--
K
E
P
A
K
--
L
--
V
V
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
G
R
G
V
Y
E
A
Q
G
L
---
E
G
QI
D
F
--
V
V
-
G
T
F
S
K
S
V
-
G
T
-
V
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
L
--
M
T
A
-----
H
--
E
K
-
R
E
R
L
W
S
N
A
R
A
L
H
G
G
L
K
A
M
G
F
-
R
L
G
--
T
E
TC
D
S
A
I
V
A
V
M
L
E
D
-
Q
E
Q
A
A
M
M
W
Q
A
L
L
D
G
-
G
L
Y
V
N
M
A
R
P
P
A
T
P
A
G
T
F
L
L
R
C
S
I
C
A
E
H
T
P
A
Q
I
Q
T
V
L
G
M
F
Q
A
A
G
R
A
V
G
V
I
14
PsiBlast_PDB
74.84
31%
0
- C1 -
2W8W
1
?
A:
[26-418]
-
K
F
D
G
L
I
A
E
R
-
Q
K
L
L
D
S
G
V
T
D
P
---
F
----
A
I
V
M
E
Q
-------
V
K
S
P
T
E
A
V
-
I
-
R
G
K
D
T
--
I
L
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
E
A
L
E
K
F
G
S
G
T
Y
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
T
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
G
--
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
D
K
R
L
G
R
L
P
--
K
E
P
A
K
--
L
--
V
V
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
G
R
G
V
Y
E
A
Q
G
L
---
E
G
QI
D
F
--
V
V
-
G
T
F
S
K
S
V
-
G
T
-
V
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
L
--
M
T
A
-----
H
--
E
K
-
R
E
R
L
W
S
N
A
R
A
L
H
G
G
L
K
A
M
G
F
-
R
L
G
--
T
E
TC
D
S
A
I
V
A
V
M
L
E
D
-
Q
E
Q
A
A
M
M
W
Q
A
L
L
D
G
-
G
L
Y
V
N
M
A
R
P
P
A
T
P
A
G
T
F
L
L
R
C
S
I
C
A
E
H
T
P
A
Q
I
Q
T
V
L
G
M
F
Q
A
A
G
R
A
V
G
V
I
11
PsiBlast_PDB
74.55
31%
2
- C1 -
2XBN
1
?
A:
[26-418]
-
K
F
D
G
L
I
A
E
R
-
Q
K
L
L
D
S
G
V
T
D
P
---
F
----
A
I
V
M
E
Q
-------
V
K
S
P
T
E
A
V
-
I
-
R
G
K
D
T
--
I
L
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
E
A
L
E
K
F
G
S
G
T
N
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
T
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
G
--
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
D
K
R
L
G
R
L
P
--
K
E
P
A
K
--
L
--
V
V
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
G
R
G
V
Y
E
A
Q
G
L
---
E
G
QI
D
F
--
V
V
-
G
T
F
S
K
S
V
-
G
T
-
V
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
L
--
M
T
A
-----
H
--
E
K
-
R
E
R
L
W
S
N
A
R
A
L
H
G
G
L
K
A
M
G
F
-
R
L
G
--
T
E
TC
D
S
A
I
V
A
V
M
L
E
D
-
Q
E
Q
A
A
M
M
W
Q
A
L
L
D
G
-
G
L
Y
V
N
M
A
R
P
P
A
T
P
A
G
T
F
L
L
R
C
S
I
C
A
E
H
T
P
A
Q
I
Q
T
V
L
G
M
F
Q
A
A
G
R
A
V
G
V
I
41
HHSearch
72.97
37%
19
- C1 -
3A2B
2
?
A:
[16-392]
-----------
E
E
L
K
A
K
G
L
Y
A
Y
---
F
RPI-
Q
-
S
K
Q
D
--------
T
E
V
---
K
-
I
-
D
G
R
R
V
--
L
M
F
G
S
N
S
Y
L
G
L
T
T
D
T
R
I
I
K
A
A
Q
D
A
L
E
K
Y
G
T
G
C
A
G
S
R
F
L
N
G
T
L
D
I
H
V
E
L
E
E
K
L
S
A
Y
V
G
K
E
A
A
I
L
F
S
T
G
F
Q
S
N
L
G
P
L
S
C
L
M
G
--
R
N
D
Y
I
L
L
D
E
R
D
H
A
S
I
I
D
G
S
R
L
S
F
S
K
V
I
K
Y
G
H
N
N
M
E
D
L
R
A
K
L
S
R
L
P
--
E
D
S
A
K
--
L
--
I
C
T
D
G
I
F
S
M
E
G
D
I
V
N
L
P
E
L
T
S
I
A
N
E
F
D
A
A
V
M
V
D
D
A
H
S
L
G
V
I
G
H
K
G
A
G
T
A
S
H
F
G
L
ND-
D
V
--
D
L
--
I
M
-
G
T
F
S
K
S
L
-
A
S
-
L
G
G
F
V
A
G
D
A
D
V
I
D
F
L
K
H
N
A
R
S
V
M
F
S
A
S
M
T
P
A
S
V
A
S
T
L
K
A
L
E
I
I
--
Q
N
E
-----
P
--
E
H
-
I
E
K
L
W
K
N
T
D
Y
A
K
A
Q
L
L
D
H
G
F
-
D
L
G
--
A
T
--
E
S
P
I
L
P
I
F
I
R
S
-
N
E
K
T
F
W
V
T
K
M
L
Q
D
D
-
G
V
F
V
N
P
V
V
S
P
A
V
P
A
E
E
S
L
I
R
F
S
L
M
A
T
H
T
Y
D
Q
I
D
E
A
I
E
K
M
V
K
V
F
K
Q
A
---
21
PsiBlast_CBE
71.65
31%
1
- C1 -
4BMK
4
?
B:
[48-438]
-
K
F
D
G
L
I
A
E
R
-
Q
K
L
L
D
S
G
V
T
D
P
---
F
----
A
I
V
M
E
Q
-------
V
K
S
P
T
E
A
V
-
I
-
R
G
K
D
T
--
I
L
L
G
T
Y
N
Y
M
G
M
T
F
D
P
D
V
I
A
A
G
K
E
A
L
E
K
F
G
S
G
T
N
G
S
R
M
L
N
G
T
F
H
D
H
M
E
V
E
Q
A
L
R
D
F
Y
G
T
T
G
A
I
V
F
S
T
G
Y
M
A
N
L
G
I
I
S
T
L
A
G
--
K
G
E
Y
V
I
L
D
A
D
S
H
A
S
I
Y
D
G
C
Q
Q
G
N
A
E
I
V
R
F
R
H
N
S
V
E
D
L
D
K
R
L
G
R
L
P
--
K
E
P
A
K
--
L
--
V
V
L
E
G
V
Y
S
M
L
G
D
I
A
P
L
K
E
M
V
A
V
A
K
K
H
G
A
M
V
L
V
D
E
A
H
S
M
G
F
F
G
P
N
G
R
G
V
Y
E
A
Q
G
L
---
E
G
QI
D
F
--
V
V
-
G
T
F
S
A
S
V
-
G
T
-
V
G
G
F
V
V
S
N
H
P
K
F
E
A
V
R
L
A
C
R
P
Y
I
F
T
A
S
L
P
P
S
V
V
A
T
A
T
T
S
I
R
K
L
--
M
T
A
-----
H
--
E
K
-
R
E
R
L
W
S
N
A
R
A
L
H
G
G
L
K
A
M
G
F
-
R
L
G
--
T
E
TC
D
S
A
I
V
A
V
M
L
E
D
-
Q
E
Q
A
A
M
M
W
Q
A
L
L
D
G
-
G
L
Y
V
N
M
A
----------
L
L
R
C
S
I
C
A
E
H
T
P
A
Q
I
Q
T
V
L
G
M
F
Q
A
A
G
R
A
V
G
--