@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu30610: (2016-07-20 )
MSFLHVDHVTHTYFSIKEKTTAVRDIHFDAEKGDFISFLGPSGCGKTTLLSIIAGLIEPSEGRVLIEGREPNQKEHNIGYMLQQDYLFPWKSIEENVLLGLKIADTLTEESKAAALGLLPEFGLIDVEKKYPKELSGGMRQRAALARTLAPNPSLLLLDEPFSALDFQTKLSLENLVFRTLKEYQKTAVLVTHDIGEAIAMSDTIFLFSNQPGTIHQIFTIPKELAAMLPFDARQEPSFQTLFQTIWKELNSLEKQQRNH
Atome Classification :
(53 SA)
-.........10........20........30........40........50........60.......------.--------70----..--------.---------.-------...-------.-------.80...-.....90........---100--...----....-.110.......120--.......130---........140.......150.......160.......170....-...180.......190.......200.......210--.........220--.......230....--------------------...240.......250.......260------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-M
S
F
L
H
V
DHV
T
H
T
Y
F
S
I
KEK
T
T
A
V
R
D
I
H
FDAEKG
D
F
I
S
F
LGPSGC
G
K
T
T
L
L
S
I
I
A
G
L
IEPSE
G
R
V
L
I
EG------R--------E-----PN--------Q---------K-------EHN-------I-------
G
Y
M
L
QQ-DYLF
P
W
K
SIEEN
V
L
L
---
G
-
L
--
K
I
A
----
D
TLT-EESK
A
A
ALGLLPEF--GLI
D
V
E
K
K
Y
----
P
K
E
L
SG
G
M
R
Q
R
A
A
L
A
R
TLAPNP
S
L
L
L
LDEPFSALD
F
Q
TKL
S
L
E
N
L
-
V
F
R
T
L
K
E
Y
Q
K
T
A
V
L
V
THDIGEAIAMS
D
T
I
F
L
FSN----QPG
T
I
H
Q
I
F
T
I
P
--
K
E
L
A
A
MLPFDARQE--------------------P
S
F
Q
T
L
F
Q
T
I
W
K
E
L
N
S
L
E
K
Q
QRNH--------------------------------------------------------------------------------------------------
104
Fugue
81.50
33%
-13
- C1 -
1OXS
23
?
C:
[1-352]
-
M
V
R
I
I
V
K
N
V
S
K
V
F
--
K
K
G
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
------
R
--------
L
-----
V
A
SNGKLIVP
P
---------
E
-------
D
R
K
-------
I
-------
G
M
V
F
Q
T
-
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
---
P
-
L
--
T
N
M
----
K
M
S
K
-
E
E
I
R
K
R
V
E
E
V
A
K
I
L
--
D
I
H
H
V
L
N
H
F
----
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
-
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
------
G
K
L
V
Q
V
G
K
-----------
P
E
D
L
Y
D
N
--------------------
P
V
S
I
Q
V
A
S
L
I
-
G
E
I
N
E
L
E
G
K
V
T
N
E
GVVIGSLRFPVSVSSDRAIIGIRPEDVKLSKDVIKDDSWILVGKGKVKVIGYQGGLFRITITPLDSEEEIFTYSDHPIHSGEEVLVYVRKDKIKVFEK
115
HHSearch
72.23
37%
-58
- C1 -
1Z47
1
?
A:
[13-228]
--
M
T
I
E
F
V
G
V
E
K
I
Y
P
G
---
G
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
------
K
--------
R
-----
V
T
--------
D
LPP------
Q
-------
K
R
N
-------
V
-------
G
L
V
F
Q
N
-
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
---
G
-
L
--
R
E
K
----
R
V
P
K
-
D
E
M
D
A
R
V
R
E
L
L
R
F
M
--
R
L
E
S
Y
A
N
R
F
----
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
-
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
------
G
N
V
E
Q
F
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
122
HHSearch
71.94
36%
-62
- C1 -
3RLF
3
MALK_ECOLI
A:
[2-216]
--
A
S
V
Q
L
Q
N
V
T
K
A
W
G
----
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
------
K
--------
R
-----
M
N
--------
D
TPP------
A
-------
E
R
G
-------
V
-------
G
M
V
F
Q
S
-
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
---
G
-
L
--
K
L
A
----
G
A
K
K
-
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
--
Q
L
A
H
L
L
D
R
K
----
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
-
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
------
G
R
V
A
Q
V
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
107
Fugue
71.81
31%
7
- C1 -
1Z47
1
?
A:
[11-355]
G
S
M
T
I
E
F
V
G
V
E
K
I
Y
---
P
G
G
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
------
K
--------
R
-----
V
T
DLP-----
P
---------
Q
-------
K
R
N
-------
V
-------
G
L
V
F
Q
N
-
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
---
G
-
L
--
R
E
K
----
R
V
P
K
-
D
E
M
D
A
R
V
R
E
L
L
R
F
M
--
R
L
E
S
Y
A
N
R
F
----
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
-
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
GNVE
Q
F
G
T
P
E
E
V
Y
E
K
P
GT
L
F
V
A
S
F
I
G
E
S
N
V
W
T
--------------------
R
A
V
Q
N
G
R
I
E
V
A
G
A
A
L
P
V
D
P
A
V
S
E
G
S
E
V
A
V
V
V
R
PKD
V
E
L
Q
P
A
S
EREAHAQVV
R
S
A
F
KGS
Y
S
A
C
W
I
R
T
KD
G
E
V
W
E
V
H
V
P
SADRHRWSPG
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R--------------------
21
PsiBlast_CBE
71.25
39%
-29
- C1 -
1Z47
1
?
B:
[30-233]
----------------------
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
------
K
--------
R
VTDL-
P
P
--------
Q
---------
K
--------
R
N
-------
V
-------
G
L
V
F
Q
N
-
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
---
G
-
L
--
R
E
K
----
R
V
P
K
-
D
E
M
D
A
R
V
R
E
L
L
R
F
M
--
R
L
E
S
Y
A
N
R
F
----
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
-
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
------
G
N
V
E
Q
-
F
G
T
P
--
E
E
V
---------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
70.83
35%
-36
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[5-237]
----
L
H
I
G
H
L
S
K
S
F
----
Q
N
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
------
K
--------
T
-----
I
F
--------
S
---------
K
NTNLPVR
E
R
R
-------
L
-------
G
Y
L
V
Q
E
-
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
---
G
-
L
--
G
N
G
----
K
G
R
T
-
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
--
G
I
S
E
L
A
G
R
Y
----
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
-
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
GRIL
Q
T
A
S
P
H
E
L
Y
R
Q
P
--
A
D
L
D
A
A
L
-----------------------------------------------------------------------------------------------------------------------------------------------------
108
Fugue
70.62
28%
-33
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
--
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
------
Q
ELTTLSES
E
-----
L
T
--------
K
---------
A
-------
R
R
Q
-------
I
-------
G
M
I
F
Q
H
-
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
---
P
-
L
--
E
L
D
----
N
T
P
K
-
D
E
V
K
R
R
V
T
E
L
L
S
L
V
--
G
L
G
D
K
H
D
S
Y
----
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
-
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
GELI
E
Q
D
T
V
S
E
V
F
S
H
P
--
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
LDIPEDYQERLQAEPFTDCV
P
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
NVNNNIISAQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEV-------------------------------------------------
24
PsiBlast_CBE
69.39
34%
-61
- C1 -
3PUZ
2
MALK_ECOLI
B:
[2-215]
--
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
----
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
------
K
--------
R
-----
M
N
--------
D
TPP------
A
-------
E
R
G
-------
V
-------
G
M
V
F
Q
S
-
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
---
G
-
L
--
K
L
A
----
G
A
K
K
-
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
--
Q
L
A
H
L
L
D
R
K
----
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
-
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
------
A
G
R
V
A
Q
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
69.02
34%
-62
- C1 -
3PUW
5
MALK_ECOLI
A:
[2-215]
--
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
----
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
------
K
--------
R
-----
M
N
--------
D
TPP------
A
-------
E
R
G
-------
V
-------
G
M
V
F
Q
S
-
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
---
G
-
L
--
K
L
A
----
G
A
K
K
-
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
--
Q
L
A
H
L
L
D
R
K
----
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
-
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
------
A
G
R
V
A
Q
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
68.90
34%
-65
- C1 -
4KHZ
-
?
A:
[2-215]
--
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
----
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
------
K
--------
R
-----
M
N
--------
D
TPP------
A
-------
E
R
G
-------
V
-------
G
M
V
F
Q
S
-
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
---
G
-
L
--
K
L
A
----
G
A
K
K
-
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
--
Q
L
A
H
L
L
D
R
K
----
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
-
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
------
A
G
R
V
A
Q
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
68.74
35%
-33
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[5-242]
----
L
H
I
G
H
L
S
K
S
F
----
Q
N
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
------
K
--------
T
-----
I
F
--------
S
---------
K
N
T
N
L
P
VR
E
R
R
-------
L
-------
G
Y
L
V
Q
E
-
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
---
G
-
L
--
G
N
G
----
K
G
R
T
-
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
--
G
I
S
E
L
A
G
R
Y
----
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
-
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
GRIL
Q
T
A
S
P
H
E
L
Y
R
Q
P
--
A
D
L
D
A
A
L
-----------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
68.26
34%
-63
- C1 -
3PUX
5
MALK_ECOLI
A:
[2-215]
--
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
----
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
------
K
--------
R
-----
M
N
--------
D
TPP------
A
-------
E
R
G
-------
V
-------
G
M
V
F
Q
S
-
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
---
G
-
L
--
K
L
A
----
G
A
K
K
-
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
--
Q
L
A
H
L
L
D
R
K
----
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
-
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
------
A
G
R
V
A
Q
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
68.12
34%
-64
- C1 -
4KI0
4
MALK_ECOLI
A:
[2-215]
--
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
----
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
------
K
--------
R
-----
M
N
--------
D
TPP------
A
-------
E
R
G
-------
V
-------
G
M
V
F
Q
S
-
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
---
G
-
L
--
K
L
A
----
G
A
K
K
-
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
--
Q
L
A
H
L
L
D
R
K
----
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
-
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
------
A
G
R
V
A
Q
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
68.10
34%
-64
- C1 -
3PUV
5
MALK_ECOLI
A:
[2-215]
--
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
----
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
------
K
--------
R
-----
M
N
--------
D
TPP------
A
-------
E
R
G
-------
V
-------
G
M
V
F
Q
S
-
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
---
G
-
L
--
K
L
A
----
G
A
K
K
-
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
--
Q
L
A
H
L
L
D
R
K
----
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
-
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
------
A
G
R
V
A
Q
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
68.08
34%
-64
- C1 -
3PUY
3
MALK_ECOLI
B:
[2-225]
--
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
----
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
------
K
--------
R
-----
M
N
--------
D
TPP------
A
-------
E
R
G
-------
V
-------
G
M
V
F
Q
S
-
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
---
G
-
L
--
K
L
A
----
G
A
K
K
-
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
--
Q
L
A
H
L
L
D
R
K
----
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
-
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
------
A
G
R
V
A
Q
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
68.06
34%
-59
- C1 -
3RLF
3
MALK_ECOLI
B:
[2-215]
--
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
----
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
------
K
--------
R
-----
M
N
--------
D
TPP------
A
-------
E
R
G
-------
V
-------
G
M
V
F
Q
S
-
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
---
G
-
L
--
K
L
A
----
G
A
K
K
-
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
--
Q
L
A
H
L
L
D
R
K
----
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
-
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
------
A
G
R
V
A
Q
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
67.47
34%
-60
- C1 -
3PUW
5
MALK_ECOLI
B:
[2-225]
--
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
----
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
------
K
--------
R
-----
M
N
--------
D
TPP------
A
-------
E
R
G
-------
V
-------
G
M
V
F
Q
S
-
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
---
G
-
L
--
K
L
A
----
G
A
K
K
-
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
--
Q
L
A
H
L
L
D
R
K
----
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
-
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
------
A
G
R
V
A
Q
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
67.37
34%
-63
- C1 -
3RLF
3
MALK_ECOLI
A:
[2-215]
--
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
----
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
------
K
--------
R
-----
M
N
--------
D
TPP------
A
-------
E
R
G
-------
V
-------
G
M
V
F
Q
S
-
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
---
G
-
L
--
K
L
A
----
G
A
K
K
-
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
--
Q
L
A
H
L
L
D
R
K
----
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
-
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
------
A
G
R
V
A
Q
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
67.19
34%
-63
- C1 -
4JBW
-
MALK_ECOLI
A:
[2-215]
--
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
----
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
------
K
--------
R
-----
M
N
--------
D
TPP------
A
-------
E
R
G
-------
V
-------
G
M
V
F
Q
S
-
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
---
G
-
L
--
K
L
A
----
G
A
K
K
-
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
--
Q
L
A
H
L
L
D
R
K
----
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
-
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
------
A
G
R
V
A
Q
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
66.75
34%
-59
- C1 -
4KI0
3
MALK_ECOLI
B:
[2-215]
--
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
----
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
------
K
--------
R
-----
M
N
--------
D
TPP------
A
-------
E
R
G
-------
V
-------
G
M
V
F
Q
S
-
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
---
G
-
L
--
K
L
A
----
G
A
K
K
-
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
--
Q
L
A
H
L
L
D
R
K
----
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
-
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
------
A
G
R
V
A
Q
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
HHSearch
66.70
37%
-35
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[2-226]
-
T
A
A
L
H
I
G
H
L
S
K
S
F
Q
----
N
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
------
K
--------
T
-----
I
F
SKN
T
N
L
P
-
V
---------
R
-------
E
R
R
-------
L
-------
G
Y
L
V
Q
E
-
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
---
G
-
L
--
G
N
G
----
K
G
R
T
-
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
--
G
I
S
E
L
A
G
R
Y
----
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
-
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
------
G
R
I
L
Q
T
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
62.95
35%
-30
- C1 -
3TIF
7
Y796_METJA
B:
[1-218]
---
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
------
I
--------
K
-----
T
N
--------
D
LDDDELTKI
R
-------
R
D
K
-------
I
-------
G
F
V
F
Q
Q
-
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
---
P
-
L
IF
K
Y
R
----
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
-----
M
A
E
L
E
E
R
F
ANHK
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
-
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
F
G
E
R
I
I
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
HHSearch
62.01
30%
-54
- C1 -
4YER
4
?
A:
[4-247]
--
D
I
I
V
V
E
N
L
V
K
K
F
G
----
D
F
E
A
V
K
G
V
S
F
S
V
K
K
G
E
I
F
A
F
L
G
P
N
G
A
G
K
T
T
T
I
H
M
L
T
T
L
L
K
P
T
S
G
K
A
W
V
A
G
------
H
--------
D
-----
V
L
KE
P
R
----
E
---------
V
-------
R
R
K
-------
I
-------
G
I
V
F
Q
D
-
Q
S
L
D
R
E
L
T
A
Y
E
N
M
Y
I
---
H
-
G
--
K
I
Y
----
G
Y
G
G
-
E
K
L
K
K
R
I
L
E
L
L
E
F
V
--
E
L
L
E
F
K
D
K
P
----
V
K
T
F
S
G
G
M
A
R
R
L
E
I
A
R
S
L
I
H
E
P
E
V
L
F
L
D
E
P
T
I
G
L
D
P
H
T
R
A
H
M
W
E
Y
-
I
S
K
M
K
K
E
H
N
M
T
I
F
L
T
T
H
Y
M
D
E
A
E
Q
L
A
D
R
V
A
I
I
D
H
------
G
K
I
I
A
L
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
61.36
35%
-30
- C1 -
1L2T
4
Y796_METJA
B:
[1-218]
---
M
I
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
------
I
--------
K
-----
T
N
--------
D
LDDDELTKI
R
-------
R
D
K
-------
I
-------
G
F
V
F
Q
Q
-
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
---
P
-
L
IF
K
Y
R
----
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
-----
M
A
E
L
E
E
R
F
ANHK
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
-
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
F
G
E
R
I
I
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
61.35
35%
-29
- C1 -
1L2T
4
Y796_METJA
A:
[1-218]
---
M
I
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
------
I
--------
K
-----
T
N
--------
D
LD
D
D
E
L
T
K
I
R
-------
R
D
K
-------
I
-------
G
F
V
F
Q
Q
-
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
---
P
-
L
IF
K
Y
R
----
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
-----
M
A
E
L
E
E
R
F
ANHK
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
-
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
F
G
E
R
I
I
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
60.98
35%
-36
- C1 -
3TIF
7
Y796_METJA
A:
[1-218]
---
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
------
I
--------
K
-----
T
N
--------
D
LD
D
D
E
L
T
K
I
R
-------
R
D
K
-------
I
-------
G
F
V
F
Q
Q
-
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
---
P
-
L
IF
K
Y
R
----
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
-----
M
A
E
L
E
E
R
F
ANHK
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
-
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
R
F
G
E
R
I
I
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
60.63
34%
-48
- C1 -
4YMU
2
?
A:
[1-224]
---
M
I
F
V
N
D
V
Y
K
N
F
G
S
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
------
V
--------
K
-----
I
N
--------
N
---------
G
-------
K
V
N
-------
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
-
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
---
A
P
V
--
K
V
K
----
K
M
N
K
-
K
E
A
E
E
L
A
V
D
L
L
A
K
V
--
G
L
L
D
K
K
D
Q
Y
----
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
--
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
GVIV
E
E
G
T
P
E
E
I
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
55.92
35%
-27
- C1 -
4U00
3
?
A:
[19-231]
----------------------
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
LSVKDD
R
--------
A
-----
L
R
--------
E
---------
I
-------
R
R
E
-------
V
-------
G
M
V
F
Q
Q
-
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
---
A
P
M
--
R
V
R
----
R
W
P
R
-
E
K
A
E
K
K
A
L
E
L
L
E
R
V
--
G
I
L
D
Q
A
R
K
Y
----
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
--
V
M
R
D
L
A
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
GQIV
E
E
G
R
P
E
E
I
F
T
R
P
--
K
E
----------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
54.59
34%
-18
- C1 -
1VCI
1
?
A:
[26-243]
---------------------
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
------
R
--------
D
-----
V
T
--------
Y
LPP------
K
-------
D
R
N
-------
I
-------
S
M
V
F
Q
-------
H
M
T
V
Y
E
N
I
A
F
---
P
-
L
----
K
KFP
K
D
E
I
D
-
K
R
V
R
W
A
A
E
L
L
Q
I
E
------
E
L
L
N
R
Y
----
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
-
I
K
K
L
Q
Q
K
L
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
GQLL
Q
I
G
S
P
T
E
V
Y
L
R
P
--
N
S
V
---------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
49.67
32%
-49
- C1 -
2OLK
2
?
B:
[39-234]
----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
------
I
--------
N
-----
L
K
--------
A
---------
K
-------
D
T
N
LNKVREE
V
-------
G
M
V
F
Q
R
-
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
---
A
P
M
--
K
V
R
----
K
W
P
R
-
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
K
A
H
A
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
--
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
49.09
32%
-40
- C1 -
3C4J
4
?
B:
[39-234]
----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
------
I
--------
N
-----
L
K
--------
A
---------
K
-------
D
T
N
LNKVREE
V
-------
G
M
V
F
Q
R
-
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
---
A
P
M
--
K
V
R
----
K
W
P
R
-
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
K
A
H
A
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
--
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
49.02
33%
-50
- C1 -
3C41
3
?
K:
[18-213]
----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
------
I
--------
N
-----
L
K
--------
A
---------
K
-------
D
T
N
LNKVREE
V
-------
G
M
V
F
Q
R
-
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
---
A
P
M
--
K
V
R
----
K
W
P
R
-
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
K
A
H
A
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
--
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
48.85
32%
-43
- C1 -
2OLK
1
?
D:
[39-234]
----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
------
I
--------
N
-----
L
K
--------
A
---------
K
-------
D
T
N
LNKVREE
V
-------
G
M
V
F
Q
R
-
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
---
A
P
M
--
K
V
R
----
K
W
P
R
-
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
K
A
H
A
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
--
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
48.77
32%
-43
- C1 -
3C4J
3
?
A:
[39-234]
----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
------
I
--------
N
-----
L
K
--------
A
---------
K
-------
D
T
N
L
N
K
V
R
E
E
V
-------
G
M
V
F
Q
R
-
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
---
A
P
M
--
K
V
R
----
K
W
P
R
-
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
K
A
H
A
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
--
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
47.46
33%
-48
- C1 -
3C41
3
?
J:
[18-213]
----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
------
I
--------
N
-----
L
K
--------
A
---------
K
-------
D
T
N
LNKVREE
V
-------
G
M
V
F
Q
R
-
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
---
A
P
M
--
K
V
R
----
K
W
P
R
-
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
K
A
H
A
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
--
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
47.31
32%
-43
- C1 -
2OLJ
4
?
A:
[39-234]
----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
------
I
--------
N
-----
L
K
--------
A
---------
K
-------
D
T
N
L
N
K
V
R
E
E
V
-------
G
M
V
F
Q
R
-
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
---
A
P
M
--
K
V
R
----
K
W
P
R
-
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
K
A
H
A
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
--
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
46.93
32%
-37
- C1 -
2OLJ
3
?
B:
[39-234]
----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
------
I
--------
N
-----
L
K
--------
A
---------
K
-------
D
T
N
LNKVREE
V
-------
G
M
V
F
Q
R
-
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
---
A
P
M
--
K
V
R
----
K
W
P
R
-
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
K
A
H
A
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
--
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
46.66
32%
-46
- C1 -
2Q0H
4
?
A:
[39-234]
----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
------
I
--------
N
-----
L
K
--------
A
---------
K
-------
D
T
N
L
N
K
V
R
E
E
V
-------
G
M
V
F
Q
R
-
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
---
A
P
M
--
K
V
R
----
K
W
P
R
-
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
K
A
H
A
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
--
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
46.49
32%
-44
- C1 -
2OLK
1
?
C:
[39-234]
----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
------
I
--------
N
-----
L
K
--------
A
---------
K
-------
D
T
N
LNKVREE
V
-------
G
M
V
F
Q
R
-
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
---
A
P
M
--
K
V
R
----
K
W
P
R
-
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
K
A
H
A
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
--
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
46.31
32%
-45
- C1 -
2OLK
1
?
A:
[39-234]
----------------------
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
------
I
--------
N
-----
L
K
--------
A
---------
K
-------
D
T
N
L
N
K
V
R
E
E
V
-------
G
M
V
F
Q
R
-
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
---
A
P
M
--
K
V
R
----
K
W
P
R
-
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
K
D
K
A
H
A
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
--
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
43.01
33%
-62
- C1 -
4HLU
3
ECFA1_THEMA
C:
[26-217]
----------------------
V
L
K
D
V
N
A
E
F
E
T
G
K
I
Y
V
V
V
G
K
N
G
S
G
K
T
T
L
L
K
I
L
A
G
L
L
A
A
A
-
G
E
I
F
L
D
G
------
S
PA------
D
-----
P
F
--------
L
---------
L
-------
R
K
N
-------
V
-------
G
Y
V
F
Q
N
P
S
S
Q
I
I
G
A
T
V
E
E
D
V
A
F
---
S
-
L
--
E
I
M
----
G
L
D
E
-
S
E
M
R
K
R
I
K
K
V
L
E
L
V
--
G
L
S
G
L
A
A
A
D
----
P
L
N
L
S
G
G
Q
K
Q
R
L
A
I
A
S
M
L
A
R
D
T
R
F
L
A
L
D
E
P
V
S
M
L
D
P
P
S
Q
R
E
I
F
Q
--
V
L
E
S
L
K
N
E
G
K
G
I
I
L
V
T
H
E
L
-
E
Y
L
D
D
M
D
F
I
L
H
I
S
N
------
G
T
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
42.43
33%
-62
- C1 -
4HLU
2
ECFA1_THEMA
D:
[26-217]
----------------------
V
L
K
D
V
N
A
E
F
E
T
G
K
I
Y
V
V
V
G
K
N
G
S
G
K
T
T
L
L
K
I
L
A
G
L
L
A
A
A
-
G
E
I
F
L
D
G
------
S
PA------
D
-----
P
F
--------
L
---------
L
-------
R
K
N
-------
V
-------
G
Y
V
F
Q
N
P
S
S
Q
I
I
G
A
T
V
E
E
D
V
A
F
---
S
-
L
--
E
I
M
----
G
L
D
E
-
S
E
M
R
K
R
I
K
K
V
L
E
L
V
--
G
L
S
G
L
A
A
A
D
----
P
L
N
L
S
G
G
Q
K
Q
R
L
A
I
A
S
M
L
A
R
D
T
R
F
L
A
L
D
E
P
V
S
M
L
D
P
P
S
Q
R
E
I
F
Q
--
V
L
E
S
L
K
N
E
G
K
G
I
I
L
V
T
H
E
L
-
E
Y
L
D
D
M
D
F
I
L
H
I
S
N
------
G
T
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
33.97
31%
-112
- C1 -
3J15
1
?
B:
[367-536]
--------------------------------
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
E
G
K
V
-----------------------------------
E
---------
W
-------
D
L
T
-------
V
-------
A
Y
K
P
Q
-----
Y
I
K
A
E
Y
E
G
T
V
Y
E
---
L
-
L
--
S
K
I
----
D
S
S
K
-
L
N
S
N
F
Y
K
T
E
L
L
K
P
L
--
G
I
I
D
L
Y
D
R
N
----
V
E
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
-
I
R
H
L
M
E
K
N
E
K
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
V
F
E
G
----
E
P
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
31.57
31%
-113
- C1 -
3BK7
1
?
A:
[381-550]
--------------------------------
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
E
G
K
V
-----------------------------------
E
---------
W
-------
D
L
T
-------
V
-------
A
Y
K
P
Q
-----
Y
I
K
A
E
Y
E
G
T
V
Y
E
---
L
-
L
--
S
K
I
----
D
S
S
K
-
L
N
S
N
F
Y
K
T
E
L
L
K
P
L
--
G
I
I
D
L
Y
D
R
N
----
V
E
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
-
I
R
H
L
M
E
K
N
E
K
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
V
F
E
G
----
E
P
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
18.26
31%
-3
- C1 -
2FFA
2
A:
[27-198]
-------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
------
H
--------
D
LALAD
P
N
--------
W
---------
L
-------
R
R
Q
-------
V
-------
G
V
V
L
Q
D
-
N
V
L
L
N
-
R
S
I
I
D
N
I
S
L
ANP
G
-
M
--
S
V
E
----
K
V
I
Y
-
A
A
K
L
A
G
A
H
D
F
I
S
E
L
RE
G
Y
N
T
I
V
G
E
Q
----
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
----
E
H
V
-
I
M
R
N
M
H
K
I
C
K
G
R
T
V
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
18.16
31%
-22
- C1 -
2FGJ
2
D:
[27-198]
-------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
------
H
--------
D
LALAD
P
N
--------
W
---------
L
-------
R
R
Q
-------
V
-------
G
V
V
L
Q
D
-
N
V
L
L
N
-
R
S
I
I
D
N
I
S
L
ANP
G
-
M
--
S
V
E
----
K
V
I
Y
-
A
A
K
L
A
G
A
H
D
F
I
S
E
L
RE
G
Y
N
T
I
V
G
E
Q
----
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
----
E
H
V
-
I
M
R
N
M
H
K
I
C
K
G
R
T
V
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
17.51
31%
-17
- C1 -
2FGJ
2
HLYBP_ECOLX
B:
[27-198]
-------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
------
H
--------
D
LALAD
P
N
--------
W
---------
L
-------
R
R
Q
-------
V
-------
G
V
V
L
Q
D
-
N
V
L
L
N
-
R
S
I
I
D
N
I
S
L
ANP
G
-
M
--
S
V
E
----
K
V
I
Y
-
A
A
K
L
A
G
A
H
D
F
I
S
E
L
RE
G
Y
N
T
I
V
G
E
Q
----
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
----
E
H
V
-
I
M
R
N
M
H
K
I
C
K
G
R
T
V
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
16.68
31%
-21
- C1 -
2FGJ
2
HLYBP_ECOLX
C:
[27-198]
-------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
------
H
--------
D
LALAD
P
N
--------
W
---------
L
-------
R
R
Q
-------
V
-------
G
V
V
L
Q
D
-
N
V
L
L
N
-
R
S
I
I
D
N
I
S
L
ANP
G
-
M
--
S
V
E
----
K
V
I
Y
-
A
A
K
L
A
G
A
H
D
F
I
S
E
L
RE
G
Y
N
T
I
V
G
E
Q
----
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
----
E
H
V
-
I
M
R
N
M
H
K
I
C
K
G
R
T
V
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
16.45
31%
-15
- C1 -
2FGJ
2
HLYBP_ECOLX
A:
[27-198]
-------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
------
H
--------
D
LALAD
P
N
--------
W
---------
L
-------
R
R
Q
-------
V
-------
G
V
V
L
Q
D
-
N
V
L
L
N
-
R
S
I
I
D
N
I
S
L
ANP
G
-
M
--
S
V
E
----
K
V
I
Y
-
A
A
K
L
A
G
A
H
D
F
I
S
E
L
RE
G
Y
N
T
I
V
G
E
Q
----
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
----
E
H
V
-
I
M
R
N
M
H
K
I
C
K
G
R
T
V
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
16.29
31%
-18
- C1 -
1XEF
3
HLYBP_ECOLX
B:
[21-192]
-------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
------
H
--------
D
LALAD
P
N
--------
W
---------
L
-------
R
R
Q
-------
V
-------
G
V
V
L
Q
D
-
N
V
L
L
N
-
R
S
I
I
D
N
I
S
L
ANP
G
-
M
--
S
V
E
----
K
V
I
Y
-
A
A
K
L
A
G
A
H
D
F
I
S
E
L
RE
G
Y
N
T
I
V
G
E
Q
----
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
----
E
H
V
-
I
M
R
N
M
H
K
I
C
K
G
R
T
V
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
15.82
31%
-11
- C1 -
1XEF
3
HLYBP_ECOLX
A:
[21-192]
-------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
------
H
--------
D
LALAD
P
N
--------
W
---------
L
-------
R
R
Q
-------
V
-------
G
V
V
L
Q
D
-
N
V
L
L
N
-
R
S
I
I
D
N
I
S
L
ANP
G
-
M
--
S
V
E
----
K
V
I
Y
-
A
A
K
L
A
G
A
H
D
F
I
S
E
L
RE
G
Y
N
T
I
V
G
E
Q
----
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
----
E
H
V
-
I
M
R
N
M
H
K
I
C
K
G
R
T
V
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
13.35
31%
-19
- C1 -
1XEF
3
D:
[21-192]
-------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
------
H
--------
D
LALAD
P
N
--------
W
---------
L
-------
R
R
Q
-------
V
-------
G
V
V
L
Q
D
-
N
V
L
L
N
-
R
S
I
I
D
N
I
S
L
ANP
G
-
M
--
S
V
E
----
K
V
I
Y
-
A
A
K
L
A
G
A
H
D
F
I
S
E
L
RE
G
Y
N
T
I
V
G
E
Q
----
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
----
E
H
V
-
I
M
R
N
M
H
K
I
C
K
G
R
T
V
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
13.03
31%
-16
- C1 -
1XEF
3
HLYBP_ECOLX
C:
[21-192]
-------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
------
H
--------
D
LALAD
P
N
--------
W
---------
L
-------
R
R
Q
-------
V
-------
G
V
V
L
Q
D
-
N
V
L
L
N
-
R
S
I
I
D
N
I
S
L
ANP
G
-
M
--
S
V
E
----
K
V
I
Y
-
A
A
K
L
A
G
A
H
D
F
I
S
E
L
RE
G
Y
N
T
I
V
G
E
Q
----
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
----
E
H
V
-
I
M
R
N
M
H
K
I
C
K
G
R
T
V
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------