@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu30950: (2016-07-21 )
MKILFAVSECTPFVKSGGLADVAGALPKALARLGNEVAVMLPKYSQIPEPWKKRMKKQAECTVAVGWRQQYCGIEHMAENDVNYYFIDNEYYFNRDSLYGHYDDGERFAFFSRAVLEAAKVVNVQADIVHTHDWHTAMVNYLLKEEYRKHPFYERMKSVLTIHNLQFQGIFPPDVTHDLLGLEMDHFHYERLECNGFVNFMKAGIIAADHVTTVSPTYRNEIMTPYYGEQLEQVLQYREDDVTGILNGIDDTFYQPKSDPYIEAQYDSGDLACKLENKTKLQQRMGLPEKNDIPLISMVTRLTKQKGLDLVRRIMHELLEEQDIQLVVLGTGEREFEDYFRYAEFAFHEKCRAYIGFDEPLAHQIYAGSDMFLMPSKFEPCGLGQLIALQYGAIPIVRETGGLYDTVRAYQEEEGTGNGFTFSAFNAHDLKFTIERALSFYCQQDVWKSIVKTAMNADYSWGKSAKEYQRIFEQVTRSGRDVLE
Atome Classification :
(20 SA)
.........10........20........30........40...--.....--50........60---........70.........-----80........90....-------.-------...------100---.----.---------...--....110----..-.----....120...------.------.----------.--...130........140.......150.......160.......170.......180-----....-....------.--190-.---......--------..200.......210.......220....--.-..230....--...240--........250.......260.......270........280.......290.......300.......310.---......320.......330.......340.......350.--...-...360.....-..370.......380.......390.......400.....-----.---------.410---..---.---......420.......430.......-440.-.....---.450.......460.......470.......480..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
I
L
F
AVSEC
T
P
F
V
KSGG
L
A
D
V
A
G
A
L
P
K
A
L
A
R
LGN
E
V
A
V
ML
P
K
Y
--SQI
P
E
--
P
W
K
K
R
M
K
KQA
E
C
---
T
V
A
VG
W
R
Q
Q
-YCGI
E
H
MAE-----NDV
N
Y
Y
F
ID
N
E
Y
Y
FNR-------D-------S
L
Y
------
G
-----H----Y---------DDG--
E
R
F
A
F
F
S
----
R
A
-
V
----
L
E
A
A
K
--
V
V
N
------
V
------
Q
----------
A
--
D
I
V
HT-HD
W
H
T
A
M
V
N
Y
L
L
K
E
E
Y
R
KH
P
F
Y
E
R
M
K
S
V
L
T
I
HN
L
Q
F
Q
GIFPP
D
V
T
H
D
L
L
-------GLE
M
-
D
H
F
H
------
Y
--
E
---
R
---LECN
G
F
--------
V
N
F
M
K
A
G
I
IAADH
V
T
TVSPTYRNEIMTP
Y
--
Y
-
G
E
Q
L
E
Q
V
L
Q
--
Y
RED
D
---
V
T
G
I
L
NGIDDTFYQPKSD
P
Y
I
E
A
QYDSG
D
-
L
A
C
K
LE
N
K
T
K
L
Q
Q
RMGLPEKNDI
P
L
I
S
M
V
T
R
L
T
K
QK
G
L
D
L
V
R
R
---
I
M
H
E
L
L
E
EQD
I
Q
L
V
V
LGTG
E
R
E
F
E
D
Y
F
R
Y
A
E
F
A
F
H
E
K
C
R
A
--YIG-FDE
P
L
A
H
QIYA-GSD
M
F
LMPSKFEPCGL
G
Q
L
I
A
L
QYGA
I
P
I
V
RETGG
L
Y
D
T
V
-----
R
---------
A
Y
-----
Q
E---E---EGTGNG
F
T
F
S
AFNAH
D
L
K
F
T
I
E
R
A
L
S
-
F
Y
C
Q
-
Q
D
V
W
K
---
S
I
V
K
T
A
MNADYSWGK
S
A
K
E
Y
Q
R
I
F
E
Q
V
T
RSGRDVLE
33
HHSearch
82.76
37%
-37
* C2 *
2QZS
3
GLGA_ECOLI
A:
[1-477]
M
Q
V
L
H
V
C
S
E
M
F
P
L
L
K
T
G
G
L
A
D
V
I
G
A
L
P
A
A
Q
I
A
D
G
V
D
A
R
V
L
L
P
A
F
--
P
D
I
R
R
--
G
V
T
D
----
A
Q
V
V
---
S
R
R
D
T
F
A
G
H
--
I
T
L
L
F
G
H
Y
-----
N
G
V
G
I
Y
L
I
D
A
P
H
L
Y
D
R
P------
G
-------
S
P
Y
HDTNLF
A
-----
Y
----
T
---------
D
N
V
--
L
R
F
A
L
L
G
----
W
V
-
G
A
E
M
A
S
G
L
D
P
----
F
------
W
------
R
----------
P
--
D
V
V
H
A
-
H
D
W
H
A
G
L
A
P
A
Y
L
A
A
R
------
G
R
P
A
K
S
V
F
T
V
H
N
L
A
Y
Q
G
M
F
Y
A
H
H
M
N
-
D
I
-------
Q
L
P
W
-
S
F
F
N
------
I
--
H
---
G
---
L
E
F
N
G
Q
--------
I
S
F
L
K
A
G
L
Y
Y
A
D
H
I
T
A
V
S
P
T
Y
A
R
E
I
T
E
P
Q
FA
Y
-
G
M
--
E
G
L
L
Q
Q
R
H
R
E
G
R
---
L
S
G
V
L
N
G
V
D
E
K
I
W
S
P
E
T
D
L
L
L
A
S
R
Y
T
R
D
T
-
L
E
D
K
A
E
N
K
R
Q
L
Q
I
A
M
G
L
K
V
D
D
K
V
P
L
F
A
V
V
S
R
L
T
S
Q
K
G
L
D
L
V
L
E
---
A
L
P
G
L
L
E
-
Q
G
G
Q
L
A
L
L
G
A
G
D
P
V
L
Q
E
G
F
L
A
A
A
A
E
Y
P
G
Q
V
G
V
--
Q
I
G
-
Y
H
E
A
F
S
H
R
I
M
G
-
G
A
D
V
I
L
V
P
S
R
F
E
P
C
G
L
T
Q
L
Y
G
L
K
Y
G
T
L
P
L
V
R
R
T
G
G
L
A
D
T
V
-----
S
---------
D
C
-----
S
L
E
N
L
A
---
D
G
V
A
S
G
F
V
F
E
D
S
N
A
W
S
L
L
R
A
I
R
R
A
F
V
-
L
W
S
R
-
P
S
L
W
R
---
F
V
Q
R
Q
A
M
A
M
D
F
S
W
Q
V
A
A
K
S
Y
R
E
L
Y
Y
R
L
K
--------
3
PsiBlast_PDB
81.34
36%
-27
- C2 -
2QZS
3
GLGA_ECOLI
A:
[1-473]
M
Q
V
L
H
V
C
S
E
M
F
P
L
L
K
T
G
G
L
A
D
V
I
G
A
L
P
A
A
Q
I
A
D
G
V
D
A
R
V
L
L
P
A
F
--
P
D
I
-------
R
R
G
V
T
D
A
Q
V
------
V
S
R
R
D
T
-
F
A
G
--
H
I
T
L
L
F
G
H
Y
N
G
V
G
I
Y
L
I
D
A
P
H
L
Y
D
R
PGSPYHD
T
-------
N
L
F
------
A
-----
Y
----
T
---------
D
N
V
--
L
R
F
A
L
L
G
----
W
V
-
G
----
A
E
M
A
S
--
G
L
D
------
P
FW----
R
----------
P
--
D
V
V
H
A
-
H
D
W
H
A
G
L
A
P
A
Y
L
A
A
R
G
R
P
------
A
K
S
V
F
T
V
H
N
L
A
Y
Q
G
M
F
Y
A
H
H
M
N
D
I
--------
Q
L
P
W
-
S
F
F
N
------
I
--
H
---
G
---
L
E
F
N
G
Q
--------
I
S
F
L
K
A
G
L
Y
Y
A
D
H
I
T
A
V
S
P
T
Y
A
R
E
I
T
E
P
Q
--
F
-
A
Y
G
M
E
G
L
L
Q
Q
R
H
R
E
G
R
---
L
S
G
V
L
N
G
V
D
E
K
I
W
S
P
E
T
D
L
L
L
A
S
R
Y
T
R
D
T
-
L
E
D
K
A
E
N
K
R
Q
L
Q
I
A
M
G
L
K
V
D
D
K
V
P
L
F
A
V
V
S
R
L
T
S
Q
K
G
L
D
L
V
L
E
---
A
L
P
G
L
L
E
-
Q
G
G
Q
L
A
L
L
G
A
G
D
P
V
L
Q
E
G
F
L
A
A
A
A
E
Y
P
G
Q
V
G
V
--
Q
I
G
-
Y
H
E
A
F
S
H
R
I
M
G
-
G
A
D
V
I
L
V
P
S
R
F
E
P
C
G
L
T
Q
L
Y
G
L
K
Y
G
T
L
P
L
V
R
R
T
G
G
L
A
D
T
V
-----
S
---------
D
C
-----
S
L
---
E
N
L
A
D
G
V
A
S
G
F
V
F
E
D
S
N
A
W
S
L
L
R
A
I
R
R
A
F
V
-
L
W
S
R
-
P
S
L
W
R
---
F
V
Q
R
Q
A
M
A
M
D
F
S
W
Q
V
A
A
K
S
Y
R
E
L
Y
------------
7
PsiBlast_PDB
80.56
36%
-28
- C2 -
3COP
3
GLGA_ECOLI
A:
[1-473]
M
Q
V
L
H
V
C
S
E
M
F
P
L
L
K
T
G
G
L
A
D
V
I
G
A
L
P
A
A
Q
I
A
D
G
V
D
A
R
V
L
L
P
A
F
--
P
D
I
-------
R
R
G
V
T
D
A
Q
V
------
V
S
R
R
D
T
-
F
A
G
--
H
I
T
L
L
F
G
H
Y
N
G
V
G
I
Y
L
I
D
A
P
H
L
Y
D
R
PGSPYHD
T
-------
N
L
F
------
A
-----
Y
----
T
---------
D
N
V
--
L
R
F
A
L
L
G
----
W
V
-
G
----
A
E
M
A
S
--
G
L
D
------
P
FW----
R
----------
P
--
D
V
V
H
A
-
H
D
W
H
A
G
L
A
P
A
Y
L
A
A
R
G
R
P
------
A
K
S
V
F
T
V
H
N
L
A
Y
Q
G
M
F
Y
A
H
H
M
N
D
I
--------
Q
L
P
W
-
S
F
F
N
------
I
--
H
---
G
---
L
E
F
N
G
Q
--------
I
S
F
L
K
A
G
L
Y
Y
A
D
H
I
T
A
V
S
P
T
Y
A
R
E
I
T
E
P
Q
--
F
-
A
Y
G
M
E
G
L
L
Q
Q
R
H
R
E
G
R
---
L
S
G
V
L
N
G
V
D
E
K
I
W
S
P
E
T
D
L
L
L
A
S
R
Y
T
R
D
T
-
L
E
D
K
A
E
N
K
R
Q
L
Q
I
A
M
G
L
K
V
D
D
K
V
P
L
F
A
V
V
S
R
L
T
S
Q
K
G
L
D
L
V
L
E
---
A
L
P
G
L
L
E
-
Q
G
G
Q
L
A
L
L
G
A
G
D
P
V
L
Q
E
G
F
L
A
A
A
A
E
Y
P
G
Q
V
G
V
--
Q
I
G
-
Y
H
E
A
F
S
H
R
I
M
G
-
G
A
D
V
I
L
V
P
S
R
F
A
P
C
G
L
T
Q
L
Y
G
L
K
Y
G
T
L
P
L
V
R
R
T
G
G
L
A
D
T
V
-----
S
---------
D
C
-----
S
L
---
E
N
L
A
D
G
V
A
S
G
F
V
F
E
D
S
N
A
W
S
L
L
R
A
I
R
R
A
F
V
-
L
W
S
R
-
P
S
L
W
R
---
F
V
Q
R
Q
A
M
A
M
D
F
S
W
Q
V
A
A
K
S
Y
R
E
L
Y
------------
5
PsiBlast_PDB
80.34
36%
-26
- C2 -
2R4U
6
GLGA_ECOLI
A:
[1-473]
M
Q
V
L
H
V
C
S
E
M
F
P
L
L
K
T
G
G
L
A
D
V
I
G
A
L
P
A
A
Q
I
A
D
G
V
D
A
R
V
L
L
P
A
F
--
P
D
I
-------
R
R
G
V
T
D
A
Q
V
------
V
S
R
R
D
T
-
F
A
G
--
H
I
T
L
L
F
G
H
Y
N
G
V
G
I
Y
L
I
D
A
P
H
L
Y
D
R
PGSPYHD
T
-------
N
L
F
------
A
-----
Y
----
T
---------
D
N
V
--
L
R
F
A
L
L
G
----
W
V
-
G
----
A
E
M
A
S
--
G
L
D
------
P
FW----
R
----------
P
--
D
V
V
H
A
-
H
D
W
H
A
G
L
A
P
A
Y
L
A
A
R
G
R
P
------
A
K
S
V
F
T
V
H
N
L
A
Y
Q
G
M
F
Y
A
H
H
M
N
D
I
--------
Q
L
P
W
-
S
F
F
N
------
I
--
H
---
G
---
L
E
F
N
G
Q
--------
I
S
F
L
K
A
G
L
Y
Y
A
D
H
I
T
A
V
S
P
T
Y
A
R
E
I
T
E
P
Q
--
F
-
A
Y
G
M
E
G
L
L
Q
Q
R
H
R
E
G
R
---
L
S
G
V
L
N
G
V
D
E
K
I
W
S
P
E
T
D
L
L
L
A
S
R
Y
T
R
D
T
-
L
E
D
K
A
E
N
K
R
Q
L
Q
I
A
M
G
L
K
V
D
D
K
V
P
L
F
A
V
V
S
R
L
T
S
Q
K
G
L
D
L
V
L
E
---
A
L
P
G
L
L
E
-
Q
G
G
Q
L
A
L
L
G
A
G
D
P
V
L
Q
E
G
F
L
A
A
A
A
E
Y
P
G
Q
V
G
V
--
Q
I
G
-
Y
H
E
A
F
S
H
R
I
M
G
-
G
A
D
V
I
L
V
P
S
R
F
E
P
C
G
L
T
Q
L
Y
G
L
K
Y
G
T
L
P
L
V
R
R
T
G
G
L
A
D
T
V
-----
S
---------
D
C
-----
S
L
---
E
N
L
A
D
G
V
A
S
G
F
V
F
E
D
S
N
A
W
S
L
L
R
A
I
R
R
A
F
V
-
L
W
S
R
-
P
S
L
W
R
---
F
V
Q
R
Q
A
M
A
M
D
F
S
W
Q
V
A
A
K
S
Y
R
E
L
Y
------------
8
PsiBlast_PDB
79.85
36%
-28
- C2 -
3CX4
19
GLGA_ECOLI
A:
[1-473]
M
Q
V
L
H
V
C
S
E
M
F
P
L
L
K
T
G
G
L
A
D
V
I
G
A
L
P
A
A
Q
I
A
D
G
V
D
A
R
V
L
L
P
A
F
--
P
D
I
-------
R
R
G
V
T
D
A
Q
V
------
V
S
R
R
D
T
-
F
A
G
--
H
I
T
L
L
F
G
H
Y
N
G
V
G
I
Y
L
I
D
A
P
H
L
Y
D
R
PGSPYHD
T
-------
N
L
F
------
A
-----
Y
----
T
---------
D
N
V
--
L
R
F
A
L
L
G
----
W
V
-
G
----
A
E
M
A
S
--
G
L
D
------
P
FW----
R
----------
P
--
D
V
V
H
A
-
H
D
W
H
A
G
L
A
P
A
Y
L
A
A
R
G
R
P
------
A
K
S
V
F
T
V
H
N
L
A
Y
Q
G
M
F
Y
A
H
H
M
N
D
I
--------
Q
L
P
W
-
S
F
F
N
------
I
--
H
---
G
---
L
E
F
N
G
Q
--------
I
S
F
L
K
A
G
L
Y
Y
A
D
H
I
T
A
V
S
P
T
Y
A
R
E
I
T
E
P
Q
--
F
-
A
Y
G
M
E
G
L
L
Q
Q
R
H
R
E
G
R
---
L
S
G
V
L
N
G
V
D
E
K
I
W
S
P
E
T
D
L
L
L
A
S
R
Y
T
R
D
T
-
L
E
D
K
A
E
N
K
R
Q
L
Q
I
A
M
G
L
K
V
D
D
K
V
P
L
F
A
V
V
S
R
L
T
S
Q
K
G
L
D
L
V
L
E
---
A
L
P
G
L
L
E
-
Q
G
G
Q
L
A
L
L
G
A
G
D
P
V
L
Q
E
G
F
L
A
A
A
A
E
Y
P
G
Q
V
G
V
--
Q
I
G
-
Y
H
E
A
F
S
H
R
I
M
G
-
G
A
D
V
I
L
V
P
S
R
F
A
P
C
G
L
T
Q
L
Y
G
L
K
Y
G
T
L
P
L
V
R
R
T
G
G
L
A
D
T
V
-----
S
---------
D
C
-----
S
L
---
E
N
L
A
D
G
V
A
S
G
F
V
F
E
D
S
N
A
W
S
L
L
R
A
I
R
R
A
F
V
-
L
W
S
R
-
P
S
L
W
R
---
F
V
Q
R
Q
A
M
A
M
D
F
S
W
Q
V
A
A
K
S
Y
R
E
L
Y
------------
4
PsiBlast_PDB
79.80
36%
-26
- C2 -
2R4T
15
GLGA_ECOLI
A:
[1-473]
M
Q
V
L
H
V
C
S
E
M
F
P
L
L
K
T
G
G
L
A
D
V
I
G
A
L
P
A
A
Q
I
A
D
G
V
D
A
R
V
L
L
P
A
F
--
P
D
I
-------
R
R
G
V
T
D
A
Q
V
------
V
S
R
R
D
T
-
F
A
G
--
H
I
T
L
L
F
G
H
Y
N
G
V
G
I
Y
L
I
D
A
P
H
L
Y
D
R
PGSPYHD
T
-------
N
L
F
------
A
-----
Y
----
T
---------
D
N
V
--
L
R
F
A
L
L
G
----
W
V
-
G
----
A
E
M
A
S
--
G
L
D
------
P
FW----
R
----------
P
--
D
V
V
H
A
-
H
D
W
H
A
G
L
A
P
A
Y
L
A
A
R
G
R
P
------
A
K
S
V
F
T
V
H
N
L
A
Y
Q
G
M
F
Y
A
H
H
M
N
D
I
--------
Q
L
P
W
-
S
F
F
N
------
I
--
H
---
G
---
L
E
F
N
G
Q
--------
I
S
F
L
K
A
G
L
Y
Y
A
D
H
I
T
A
V
S
P
T
Y
A
R
E
I
T
E
P
Q
--
F
-
A
Y
G
M
E
G
L
L
Q
Q
R
H
R
E
G
R
---
L
S
G
V
L
N
G
V
D
E
K
I
W
S
P
E
T
D
L
L
L
A
S
R
Y
T
R
D
T
-
L
E
D
K
A
E
N
K
R
Q
L
Q
I
A
M
G
L
K
V
D
D
K
V
P
L
F
A
V
V
S
R
L
T
S
Q
K
G
L
D
L
V
L
E
---
A
L
P
G
L
L
E
-
Q
G
G
Q
L
A
L
L
G
A
G
D
P
V
L
Q
E
G
F
L
A
A
A
A
E
Y
P
G
Q
V
G
V
--
Q
I
G
-
Y
H
E
A
F
S
H
R
I
M
G
-
G
A
D
V
I
L
V
P
S
R
F
E
P
C
G
L
T
Q
L
Y
G
L
K
Y
G
T
L
P
L
V
R
R
T
G
G
L
A
D
T
V
-----
S
---------
D
C
-----
S
L
---
E
N
L
A
D
G
V
A
S
G
F
V
F
E
D
S
N
A
W
S
L
L
R
A
I
R
R
A
F
V
-
L
W
S
R
-
P
S
L
W
R
---
F
V
Q
R
Q
A
M
A
M
D
F
S
W
Q
V
A
A
K
S
Y
R
E
L
Y
------------
6
PsiBlast_PDB
78.05
36%
-25
- C2 -
3GUH
7
GLGA_ECOLI
A:
[1-473]
M
Q
V
L
H
V
C
S
E
M
F
P
L
L
K
T
G
G
L
A
D
V
I
G
A
L
P
A
A
Q
I
A
D
G
V
D
A
R
V
L
L
P
A
F
--
P
D
I
-------
R
R
G
V
T
D
A
Q
V
------
V
S
R
R
D
T
-
F
A
G
--
H
I
T
L
L
F
G
H
Y
N
G
V
G
I
Y
L
I
D
A
P
H
L
Y
D
R
PGSPYHD
T
-------
N
L
F
------
A
-----
Y
----
T
---------
D
N
V
--
L
R
F
A
L
L
G
----
W
V
-
G
----
A
E
M
A
S
--
G
L
D
------
P
FW----
R
----------
P
--
D
V
V
H
A
-
H
D
W
H
A
G
L
A
P
A
Y
L
A
A
R
G
R
P
------
A
K
S
V
F
T
V
H
N
L
A
Y
Q
G
M
F
Y
A
H
H
M
N
D
I
--------
Q
L
P
W
-
S
F
F
N
------
I
--
H
---
G
---
L
E
F
N
G
Q
--------
I
S
F
L
K
A
G
L
Y
Y
A
D
H
I
T
A
V
S
P
T
Y
A
R
E
I
T
E
P
Q
--
F
-
A
Y
G
M
E
G
L
L
Q
Q
R
H
R
E
G
R
---
L
S
G
V
L
N
G
V
D
E
K
I
W
S
P
E
T
D
L
L
L
A
S
R
Y
T
R
D
T
-
L
E
D
K
A
E
N
K
R
Q
L
Q
I
A
M
G
L
K
V
D
D
K
V
P
L
F
A
V
V
S
R
L
T
S
Q
K
G
L
D
L
V
L
E
---
A
L
P
G
L
L
E
-
Q
G
G
Q
L
A
L
L
G
A
G
D
P
V
L
Q
E
G
F
L
A
A
A
A
E
Y
P
G
Q
V
G
V
--
Q
I
G
-
Y
H
E
A
F
S
H
R
I
M
G
-
G
A
D
V
I
L
V
P
S
R
F
E
P
C
G
L
T
Q
L
Y
G
L
K
Y
G
T
L
P
L
V
R
R
T
G
G
L
A
D
T
V
-----
S
---------
D
C
-----
S
L
---
E
N
L
A
D
G
V
A
S
G
F
V
F
E
D
S
N
A
W
S
L
L
R
A
I
R
R
A
F
V
-
L
W
S
R
-
P
S
L
W
R
---
F
V
Q
R
Q
A
M
A
M
D
F
S
W
Q
V
A
A
K
S
Y
R
E
L
Y
------------
35
HHSearch
77.80
33%
-44
- C2 -
1RZU
1
GLGA1_RHIRD
A:
[1-477]
M
N
V
L
S
V
S
S
E
I
Y
P
L
I
K
T
G
G
L
A
D
V
V
G
A
L
P
I
A
L
E
A
H
G
V
R
T
R
T
L
I
P
G
Y
--
P
A
V
K
A
--
A
V
T
D
---
P
V
K
C
F
---
E
F
T
D
L
L
G
-
E
-
K
A
D
L
L
E
V
Q
H
-----
E
R
L
D
L
L
I
L
D
A
P
A
Y
Y
E
R
S------
G
-------
G
P
Y
------
L
GQTGK
D
----
Y
P--------
D
N
W
--
K
R
F
A
A
L
S
L
A
A
A
R
I
-
G
----
A
G
V
L
P
----
G
------
W
------
R
----------
P
--
D
M
V
H
A
-
H
D
W
Q
A
A
M
T
P
V
Y
M
R
Y
A
-----
E
T
P
E
I
P
S
L
L
T
I
H
N
I
A
F
Q
G
Q
F
G
A
N
I
F
S
-
K
L
-------
A
L
P
A
-
H
A
F
G
------
M
--
E
---
G
---
I
E
Y
Y
N
D
--------
V
S
F
L
K
G
G
L
Q
T
A
T
A
L
S
T
V
S
P
S
Y
A
E
E
I
L
T
A
E
--
F
-
G
M
G
L
E
G
-----
V
I
G
S
R
AHV
L
H
G
I
V
N
G
I
D
A
D
V
W
N
P
A
T
D
H
L
I
H
D
N
Y
S
A
A
N
-
L
K
N
R
A
L
N
K
K
A
V
A
E
H
F
R
I
D
-
D
D
G
S
P
L
F
C
V
I
S
R
L
T
W
Q
K
G
I
D
L
M
A
E
---
A
V
D
E
I
V
S
-
L
G
G
R
L
V
V
L
G
A
G
D
V
A
L
E
G
A
L
L
A
A
A
S
R
H
H
G
R
V
G
V
--
A
I
G
-
Y
-
N
E
P
L
S
H
L
M
Q
A
G
C
D
A
I
I
I
P
S
R
F
E
P
C
G
L
T
Q
L
Y
A
L
R
Y
G
C
I
P
V
V
A
R
T
G
G
L
A
D
T
V
-----
I
---------
D
A
-----
N
H
---
A
A
L
A
S
K
A
A
T
G
V
Q
F
S
P
V
T
L
D
G
L
K
Q
A
I
R
R
T
V
R
-
Y
Y
H
D
-
P
K
L
W
T
---
Q
M
Q
K
L
G
M
K
S
D
V
S
W
E
K
S
A
G
L
Y
A
A
L
Y
S
Q
L
I
S
-------
9
PsiBlast_PDB
77.79
33%
-26
- C2 -
1RZU
1
GLGA1_RHIRD
A:
[1-477]
M
N
V
L
S
V
S
S
E
I
Y
P
L
I
K
T
G
G
L
A
D
V
V
G
A
L
P
I
A
L
E
A
H
G
V
R
T
R
T
L
I
P
G
Y
--
P
A
V
------
K
A
A
V
T
D
P
V
K
C
FEF
T
D
L
L
G
E
K
A
D
-
L
L
E
V
Q
H
--------
E
R
L
D
L
L
I
L
D
A
P
A
Y
Y
E
R
-------
S
-------
G
--------
G
-----
P
----
Y
LGQTGKDYP
D
N
W
--
K
R
F
A
A
L
S
----
L
A
-
A
A
R
--
I
G
A
G
V
--
L
P
G
------
W
------
R
----------
P
--
D
M
V
H
A
-
H
D
W
Q
A
A
M
T
P
V
Y
M
R
--
Y
A
E
T
P
---
E
I
P
S
L
L
T
I
H
N
I
A
F
Q
G
Q
F
G
A
N
I
F
S
K
L
--------
A
L
P
A
-
H
A
F
G
------
M
--
E
---
G
---
I
E
Y
Y
N
D
--------
V
S
F
L
K
G
G
L
Q
T
A
T
A
L
S
T
V
S
P
S
Y
A
E
E
I
L
T
A
E
--
F
-
G
M
G
L
E
G
V
I
G
--
S
R
A
H
V
---
L
H
G
I
V
N
G
I
D
A
D
V
W
N
P
A
T
D
H
L
I
H
D
N
Y
S
A
A
N
-
L
K
N
R
A
L
N
K
K
A
V
A
E
H
F
R
I
-
D
D
D
G
S
P
L
F
C
V
I
S
R
L
T
W
Q
K
G
I
D
L
M
A
E
---
A
V
D
E
I
V
S
L
G
G
-
R
L
V
V
L
G
A
G
D
V
A
L
E
G
A
L
L
A
A
A
S
R
H
H
G
R
V
G
V
--
A
I
G
-
Y
N
E
P
L
S
H
L
M
Q
A
-
G
C
D
A
I
I
I
P
S
R
F
E
P
C
G
L
T
Q
L
Y
A
L
R
Y
G
C
I
P
V
V
A
R
T
G
G
L
A
D
T
V
IDAN
H
A
---------
A
L
-----
A
S
---
K
---
A
A
T
--
G
V
Q
F
S
P
V
T
L
D
G
L
K
Q
A
I
R
R
T
V
R
-
Y
Y
H
D
-
P
K
L
W
T
---
Q
M
Q
K
L
G
M
K
S
D
V
S
W
E
K
S
A
G
L
Y
A
A
L
Y
S
Q
L
I
S
-------
21
PsiBlast_CBE
77.18
33%
-22
- C2 -
1RZU
1
GLGA1_RHIRD
B:
[1-478]
M
N
V
L
S
V
S
S
E
I
Y
P
L
I
K
T
G
G
L
A
D
V
V
G
A
L
P
I
A
L
E
A
H
G
V
R
T
R
T
L
I
P
G
Y
--
P
A
V
------
K
A
A
V
T
D
P
V
K
C
FEF
T
D
L
L
G
E
K
A
D
-
L
L
E
V
Q
H
--------
E
R
L
D
L
L
I
L
D
A
P
A
Y
Y
E
R
-------
S
-------
G
--------
G
-----
P
----
Y
LGQTGKDYP
D
N
W
--
K
R
F
A
A
L
S
----
L
A
-
A
AR--
I
G
A
G
V
--
L
P
G
------
W
------
R
----------
P
--
D
M
V
H
A
-
H
D
W
Q
A
A
M
T
P
V
Y
M
R
--
Y
A
E
T
P
---
E
I
P
S
L
L
T
I
H
N
I
A
F
Q
G
Q
F
G
A
N
I
F
S
K
L
--------
A
L
P
A
-
H
A
F
G
------
M
--
E
---
G
---
I
E
Y
Y
N
D
--------
V
S
F
L
K
G
G
L
Q
T
A
T
A
L
S
T
V
S
P
S
Y
A
E
E
I
L
T
A
E
--
F
-
G
M
G
L
E
G
V
I
G
--
S
R
A
H
V
---
L
H
G
I
V
N
G
I
D
A
D
V
W
N
P
A
T
D
H
L
I
H
D
N
Y
S
A
A
N
-
L
K
N
R
A
L
N
K
K
A
V
A
E
H
F
R
I
-
D
D
D
G
S
P
L
F
C
V
I
S
R
L
T
W
Q
K
G
I
D
L
M
A
E
---
A
V
D
E
I
V
S
L
G
G
-
R
L
V
V
L
G
A
G
D
V
A
L
E
G
A
L
L
A
A
A
S
R
H
H
G
R
V
G
V
--
A
I
G
-
Y
N
E
P
L
S
H
L
M
Q
A
-
G
C
D
A
I
I
I
P
S
R
F
E
P
C
G
L
T
Q
L
Y
A
L
R
Y
G
C
I
P
V
V
A
R
T
G
G
L
A
D
T
V
IDANH
A
---------
A
L
-----
A
S
---
K
---
A
A
T
--
G
V
Q
F
S
P
V
T
L
D
G
L
K
Q
A
I
R
R
T
V
R
-
Y
Y
H
D
-
P
K
L
W
T
---
Q
M
Q
K
L
G
M
K
S
D
V
S
W
E
K
S
A
G
L
Y
A
A
L
Y
S
Q
L
I
S
K
------
22
Fugue
76.66
33%
-22
- C2 -
1RZU
1
GLGA1_RHIRD
A:
[1-477]
M
N
V
L
S
V
S
S
E
I
Y
P
L
I
K
T
G
G
L
A
D
V
V
G
A
L
P
I
A
L
E
A
H
G
V
R
T
R
T
L
I
P
G
Y
--
P
A
V
K
A
--
A
----
V
T
D
P
V
K
C
---
F
E
F
T
D
L
L
G
E
-
K
A
D
L
L
E
V
Q
H
-----
E
R
L
D
L
L
I
L
D
A
P
A
Y
Y
E
R
-------
S
GGPYLGQ
T
G
K
------
D
-----
Y
----
P
---------
D
N
W
--
K
R
F
A
A
L
S
----
L
A
-
A
----
A
R
I
G
A
GV
L
P
G
------
W
------
R
----------
P
--
D
M
V
H
A
-
H
D
W
Q
A
A
M
T
P
V
Y
M
R
Y
A
E
T
P
E
I
-----
P
S
L
L
T
I
H
N
I
A
F
Q
G
Q
F
G
A
N
I
F
S
K
L
--------
A
L
P
A
-
H
A
F
G
------
M
--
E
---
G
---
I
E
Y
Y
N
D
--------
V
S
F
L
K
G
G
L
Q
T
A
T
A
L
S
T
V
S
P
S
Y
A
E
E
I
L
T
A
E
--
F
-
G
M
G
L
E
G
V
I
G
--
S
R
A
H
V
---
L
H
G
I
V
N
G
I
D
A
D
V
W
N
P
A
T
D
H
L
I
H
D
N
Y
S
A
A
N
-
L
K
N
R
A
L
N
K
K
A
V
A
E
H
F
R
I
D
D
-
D
G
S
P
L
F
C
V
I
S
R
L
T
W
Q
K
G
I
D
L
M
A
E
---
A
V
D
E
I
V
S
-
L
G
G
R
L
V
V
L
G
A
G
D
V
A
L
E
G
A
L
L
A
A
A
S
R
H
H
G
R
V
G
V
--
A
I
G
-
Y
N
E
P
L
S
H
L
M
Q
A
-
G
C
D
A
I
I
I
P
S
R
F
E
P
C
G
L
T
Q
L
Y
A
L
R
Y
G
C
I
P
V
V
A
R
T
G
G
L
A
D
T
V
-----
I
DAN------
H
A
-----
A
L
---
A
---
S
K
A
A
T
G
V
Q
F
S
P
V
T
L
D
G
L
K
Q
A
I
R
R
T
V
R
-
Y
Y
H
D
-
P
K
L
W
T
---
Q
M
Q
K
L
G
M
K
S
D
V
S
W
E
K
S
A
G
L
Y
A
A
L
Y
S
Q
L
I
S
-------
2
PsiBlast_PDB
75.78
36%
-22
- C- -
3D1J
-
GLGA_ECOLI
A:
[1-473]
M
Q
V
L
H
V
S
S
E
M
F
P
L
L
K
T
G
G
L
A
D
V
I
G
A
L
P
A
A
Q
I
A
D
G
V
D
A
R
V
L
L
P
A
F
--
P
D
I
-------
R
R
G
V
T
D
A
Q
V
------
V
S
R
R
D
T
-
F
A
G
--
H
I
T
L
L
F
G
H
Y
N
G
V
G
I
Y
L
I
D
A
P
H
L
Y
D
R
PGSPYHD
T
-------
N
L
F
------
A
-----
Y
----
T
---------
D
N
V
--
L
R
F
A
L
L
G
----
W
V
-
G
----
A
E
M
A
S
--
G
L
D
------
P
FW----
R
----------
P
--
D
V
V
H
A
-
H
D
W
H
A
G
L
A
P
A
Y
L
A
A
R
G
R
P
------
A
K
S
V
F
T
V
H
N
L
A
Y
Q
G
M
F
Y
A
H
H
M
N
D
I
--------
Q
L
P
W
-
S
F
F
N
------
I
--
H
---
G
---
L
E
F
N
G
Q
--------
I
S
F
L
K
A
G
L
Y
Y
A
D
H
I
T
A
V
S
P
T
Y
A
R
E
I
T
E
P
Q
--
F
-
A
Y
G
M
E
G
L
L
Q
Q
R
H
R
E
G
R
---
L
S
G
V
L
N
G
V
D
E
K
I
W
S
P
E
T
D
L
L
L
A
S
R
Y
T
R
D
T
-
L
E
D
K
A
E
N
K
R
Q
L
Q
I
A
M
G
L
K
V
D
D
K
V
P
L
F
A
V
V
S
R
L
T
S
Q
K
G
L
D
L
V
L
E
---
A
L
P
G
L
L
E
-
Q
G
G
Q
L
A
L
L
G
A
G
D
P
V
L
Q
E
G
F
L
A
A
A
A
E
Y
P
G
Q
V
G
V
--
Q
I
G
-
Y
H
E
A
F
S
H
R
I
M
G
-
G
A
D
V
I
L
V
P
S
R
F
E
P
C
G
L
T
Q
L
Y
G
L
K
Y
G
T
L
P
L
V
R
R
T
G
G
L
A
D
T
V
-----
S
---------
D
S
-----
S
L
---
E
N
L
A
D
G
V
A
S
G
F
V
F
E
D
S
N
A
W
S
L
L
R
A
I
R
R
A
F
V
-
L
W
S
R
-
P
S
L
W
R
---
F
V
Q
R
Q
A
M
A
M
D
F
S
W
Q
V
A
A
K
S
Y
R
E
L
Y
------------
10
PsiBlast_PDB
75.53
33%
-25
- C2 -
1RZV
-
GLGA1_RHIRD
A:
[2-477]
-
N
V
L
S
V
S
S
E
I
Y
P
L
I
K
T
G
G
L
A
D
V
V
G
A
L
P
I
A
L
E
A
H
G
V
R
T
R
T
L
I
P
G
Y
--
P
A
V
------
K
A
A
V
T
D
P
V
K
C
FEF
T
D
L
L
G
E
K
A
D
-
L
L
E
V
Q
H
--------
E
R
L
D
L
L
I
L
D
A
P
A
Y
Y
E
R
-------
S
-------
G
--------
G
-----
P
----
Y
LGQTGKDYP
D
N
W
--
K
R
F
A
A
L
S
----
L
A
-
A
A
R
--
I
G
A
G
V
--
L
P
G
------
W
------
R
----------
P
--
D
M
V
H
A
-
H
D
W
Q
A
A
M
T
P
V
-----
Y
M
R
Y
A
E
T
P
E
I
P
S
L
L
T
I
H
N
I
A
F
Q
G
Q
F
G
A
N
I
F
S
K
L
--------
A
L
P
A
-
H
A
F
G
------
M
--
E
---
G
---
I
E
Y
Y
N
D
--------
V
S
F
L
K
G
G
L
Q
T
A
T
A
L
S
T
V
S
P
S
Y
A
E
E
I
L
T
A
E
--
F
-
G
M
G
L
E
G
V
I
G
--
S
R
A
H
V
---
L
H
G
I
V
N
G
I
D
A
D
V
W
N
P
A
T
D
H
L
I
H
D
N
Y
S
A
A
N
-
L
K
N
R
A
L
N
K
K
A
V
A
E
H
F
R
I
-
D
D
D
G
S
P
L
F
C
V
I
S
R
L
T
W
Q
K
G
I
D
L
M
A
E
---
A
V
D
E
I
V
S
L
G
G
-
R
L
V
V
L
G
A
G
D
V
A
L
E
G
A
L
L
A
A
A
S
R
H
H
G
R
V
G
V
--
A
I
G
-
Y
N
E
P
L
S
H
L
M
Q
A
-
G
C
D
A
I
I
I
P
S
R
F
E
P
C
G
L
T
Q
L
Y
A
L
R
Y
G
C
I
P
V
V
A
R
T
G
G
L
A
D
T
V
IDAN
H
A
---------
A
L
-----
A
S
---
K
---
A
A
T
--
G
V
Q
F
S
P
V
T
L
D
G
L
K
Q
A
I
R
R
T
V
R
-
Y
Y
H
D
-
P
K
L
W
T
---
Q
M
Q
K
L
G
M
K
S
D
V
S
W
E
K
S
A
G
L
Y
A
A
L
Y
S
Q
L
I
S
-------
1
PsiBlast_PDB
73.35
34%
-10
- C2 -
4HLN
1
?
A:
[126-623]
-
S
I
V
F
V
T
G
E
A
A
P
--------
D
V
C
G
S
L
P
I
A
L
A
A
R
G
H
R
V
M
V
V
M
P
R
Y
LN
G
T
S
D
K
--
N
Y
A
K
A
L
Y
T
G
K
H
I
---
K
I
P
C
F
G
G
S
H
-
E
V
T
F
F
H
E
Y
R
-----
D
N
V
D
W
V
F
V
D
H
P
S
Y
H
R
P
-----------------------------------
N
FGAFG----
D
N
Q
--
F
R
Y
T
L
L
C
----
Y
A
-
A
----
C
E
A
P
L
--
I
L
E
------
L
GGYIYG
Q
----------
S
--
C
M
F
V
V
-
N
D
W
H
A
S
L
V
P
V
L
L
A
A
K
Y
R
P
Y
G
V
Y
R
D
S
R
S
T
L
V
I
H
N
L
A
H
Q
G
V
E
P
A
S
T
Y
P
D
L
G
LPPEWYG
A
L
E
W
-
V
F
P
E
------
W
--
A
---
R
RHA
L
D
K
G
E
A
--------
V
N
F
L
K
G
A
V
V
T
A
D
R
I
V
T
V
S
Q
G
Y
S
W
E
V
T
T
A
E
--
G
-
G
Q
G
L
N
E
L
L
S
--
S
R
K
S
V
---
L
N
G
I
V
N
G
I
D
I
N
D
W
N
P
T
T
D
K
C
L
P
H
H
Y
S
V
D
D
-
L
S
G
K
A
K
C
K
A
E
L
Q
R
E
L
G
L
P
V
R
E
D
V
P
L
I
G
F
I
G
R
L
D
Y
Q
K
G
I
D
L
I
K
M
---
A
I
P
D
L
M
R
E
-
D
V
Q
F
V
M
L
G
S
G
D
P
V
F
E
G
W
M
R
S
T
E
S
S
Y
K
D
K
F
R
G
--
W
V
G
-
F
S
V
P
V
S
H
R
I
T
A
-
G
C
D
I
L
L
M
P
S
R
F
E
P
C
G
L
N
Q
L
Y
A
M
Q
Y
G
T
V
P
V
V
H
G
T
G
G
L
R
D
T
V
-----
E
---------
T
F
NPFGA
K
G
---
E
---
E
G
T
--
G
W
A
F
S
P
L
T
V
E
K
M
L
W
A
L
R
T
A
I
S
T
F
R
E
H
-
K
P
S
W
E
---
G
L
M
K
R
G
M
T
K
D
H
T
W
D
H
A
A
E
Q
Y
E
Q
I
F
E
-----------
11
PsiBlast_PDB
72.58
31%
-9
- C2 -
3VUE
4
SSG1_ORYSJ
A:
[10-513]
M
N
V
V
F
V
G
A
E
M
A
P
W
S
K
T
G
G
L
G
D
V
L
G
G
L
P
P
A
M
A
A
N
G
H
R
V
M
V
I
S
P
R
Y
--
D
Q
Y
K
D
--
A
W
D
T
S
V
V
A
E
-------
I
K
V
A
D
R
Y
E
-
R
V
R
F
F
H
C
Y
K
-----
R
G
V
D
R
V
F
I
D
H
P
S
F
L
E
K
-----------------------------------
K
---------
D
N
Q
--
M
R
F
S
L
L
C
----
Q
A
-
A
----
L
E
A
P
R
--
I
L
N
------
L
------
N
NNPYFKGTYG
E
--
D
V
V
F
V
C
N
D
W
H
T
G
P
L
A
S
Y
L
K
N
N
Y
Q
P
N
G
I
Y
R
N
A
K
V
A
F
C
I
H
N
I
S
Y
Q
G
R
F
---
A
F
E
D
Y
P
-------
E
L
N
L
S
E
R
F
R
------
S
--
S
---
F
---
D
F
I
D
G
Y
DTPV
E
G
R
K
I
N
W
M
K
A
G
I
L
E
A
D
R
V
L
T
V
S
P
Y
Y
A
E
E
L
I
S
G
I
--
A
R
G
C
E
L
D
N
I
M
----
R
L
T
G
---
I
T
G
I
V
N
G
M
D
V
S
E
W
D
P
S
K
D
K
Y
I
T
A
K
Y
D
A
T
T
A
I
E
A
K
A
L
N
K
E
A
L
Q
A
E
A
G
L
P
V
D
R
K
I
P
L
I
A
F
I
G
R
L
E
E
Q
K
G
P
D
V
M
A
A
---
A
I
P
E
L
M
Q
E
-
D
V
Q
I
V
L
L
G
T
G
K
K
K
F
E
K
L
L
K
S
M
E
E
K
Y
P
G
K
V
R
A
--
V
V
K
-
F
N
A
P
L
A
H
L
I
M
A
-
G
A
D
V
L
A
V
P
S
R
F
E
P
C
G
L
I
Q
L
Q
G
M
R
Y
G
T
P
C
A
C
A
S
T
G
G
L
V
D
T
V
IEGK-
T
---------
G
F
-----
H
M
---
G
---
R
L
S
V
D
C
K
V
V
E
P
S
D
V
K
K
V
A
A
T
L
K
R
A
I
K
-
V
-
V
G
-
T
P
A
Y
E
---
E
M
V
R
N
C
M
N
Q
D
L
S
W
K
G
P
A
K
N
W
E
N
V
L
L
G
L
G
V
-------
39
HHSearch
72.34
35%
9
- C2 -
4HLN
1
?
A:
[125-632]
R
S
I
V
F
V
T
G
E
A
A
P
--------
D
V
C
G
S
L
P
I
A
L
A
A
R
G
H
R
V
M
V
V
M
P
R
Y
--
L
N
G
T
S
DK
N
Y
A
K
A
L
Y
T
G
K
H
I
---
K
I
P
C
-
F
G
G
S
H
E
V
T
F
F
H
E
Y
R
-----
D
N
V
D
W
V
F
V
D
H
P
S
Y
H
R
P
-------------------------------NFGA
F
G--------
D
N
Q
--
F
R
Y
T
L
L
C
----
Y
A
-
A
----
C
E
A
P
L
--
I
L
E
LGGYIY
G
------
Q
----------
S
--
C
M
F
V
V
-
N
D
W
H
A
S
L
V
P
V
L
L
A
A
K
Y
R
P
Y
G
V
Y
R
D
S
R
S
T
L
V
I
H
N
L
A
H
Q
G
V
E
P
A
S
T
Y
P
-
D
L
-------
G
L
P
P
-
E
W
Y
G
AL
E
W
V
F
P
EW
A
RRH
A
---
L
D
K
G
E
A
--------
V
N
F
L
K
G
A
V
V
T
A
D
R
I
V
T
V
S
Q
G
Y
S
W
E
V
T
T
A
E
--
G
-
G
Q
G
L
N
E
L
L
S
--
S
R
K
S
V
---
L
N
G
I
V
N
G
I
D
I
N
D
W
N
P
T
T
D
K
C
L
P
H
H
Y
S
V
D
D
-
L
S
G
K
A
K
C
K
A
E
L
Q
R
E
L
G
L
P
V
R
E
D
V
P
L
I
G
F
I
G
R
L
D
Y
Q
K
G
I
D
L
I
K
M
---
A
I
P
D
L
M
R
-
E
D
V
Q
F
V
M
L
G
S
G
D
P
V
F
E
G
W
M
R
S
T
E
S
--
S
Y
K
D
K
F
R
G
W
V
G
-
F
S
V
P
V
S
H
R
I
T
A
-
G
C
D
I
L
L
M
P
S
R
F
E
P
C
G
L
N
Q
L
Y
A
M
Q
Y
G
T
V
P
V
V
H
G
T
G
G
L
R
D
T
V
-----
E
TFNPFGAK
G
E
E
-----------------
G
T
G
W
A
F
S
P
L
T
V
E
K
M
L
W
A
L
R
T
A
I
S
-
T
F
R
E
H
K
P
S
W
E
---
G
L
M
K
R
G
M
T
K
D
H
T
W
D
H
A
A
E
Q
Y
E
Q
I
F
E
W
A
F
V
D
Q
P
Y
V
--
12
PsiBlast_PDB
70.90
31%
-10
- C2 -
3VUF
4
SSG1_ORYSJ
A:
[10-513]
M
N
V
V
F
V
G
A
E
M
A
P
W
S
K
T
G
G
L
G
D
V
L
G
G
L
P
P
A
M
A
A
N
G
H
R
V
M
V
I
S
P
R
Y
--
D
Q
Y
K
D
--
A
W
D
T
S
V
V
A
E
-------
I
K
V
A
D
R
Y
E
-
R
V
R
F
F
H
C
Y
K
-----
R
G
V
D
R
V
F
I
D
H
P
S
F
L
E
K
-----------------------------------
K
---------
D
N
Q
--
M
R
F
S
L
L
C
----
Q
A
-
A
----
L
E
A
P
R
--
I
L
N
------
L
------
N
NNPYFKGTYG
E
--
D
V
V
F
V
C
N
D
W
H
T
G
P
L
A
S
Y
L
K
N
N
Y
Q
P
N
G
I
Y
R
N
A
K
V
A
F
C
I
H
N
I
S
Y
Q
G
R
F
---
A
F
E
D
Y
P
-------
E
L
N
L
S
E
R
F
R
------
S
--
S
---
F
---
D
F
I
D
G
Y
DTPV
E
G
R
K
I
N
W
M
K
A
G
I
L
E
A
D
R
V
L
T
V
S
P
Y
Y
A
E
E
L
I
S
G
I
--
A
R
G
C
E
L
D
N
I
M
----
R
L
T
G
---
I
T
G
I
V
N
G
M
D
V
S
E
W
D
P
S
K
D
K
Y
I
T
A
K
Y
D
A
T
T
A
I
E
A
K
A
L
N
K
E
A
L
Q
A
E
A
G
L
P
V
D
R
K
I
P
L
I
A
F
I
G
R
L
E
E
Q
K
G
P
D
V
M
A
A
---
A
I
P
E
L
M
Q
E
-
D
V
Q
I
V
L
L
G
T
G
K
K
K
F
E
K
L
L
K
S
M
E
E
K
Y
P
G
K
V
R
A
--
V
V
K
-
F
N
A
P
L
A
H
L
I
M
A
-
G
A
D
V
L
A
V
P
S
R
F
E
P
C
G
L
I
Q
L
Q
G
M
R
Y
G
T
P
C
A
C
A
S
T
G
G
L
V
D
T
V
IEGK-
T
---------
G
F
-----
H
M
---
G
---
R
L
S
V
D
C
K
V
V
E
P
S
D
V
K
K
V
A
A
T
L
K
R
A
I
K
-
V
-
V
G
-
T
P
A
Y
E
---
E
M
V
R
N
C
M
N
Q
D
L
S
W
K
G
P
A
K
N
W
E
N
V
L
L
G
L
G
V
-------
14
PsiBlast_PDB
67.00
27%
-39
- C2 -
3FRO
3
?
A:
[3-427]
M
K
V
L
L
L
G
F
E
F
L
P
-
V
K
V
G
G
L
A
E
A
L
T
A
I
S
E
A
L
A
S
L
G
H
E
V
L
V
F
T
P
S
H
--
G
----------
R
F
Q
G
E
E
I
G
---
K
I
R
V
F
G
E
E
V
-
Q
V
K
V
S
Y
E
E
R
-----
G
N
L
R
I
Y
R
I
G
G
G
L
-
L
D
S
-------
E
-------
D
V
Y
------
G
-----
P
----
G
---------
W
D
G
L
I
R
K
A
V
T
F
G
----
R
A
S
V
----
L
L
L
N
D
--
L
L
R
------
E
------
E
----------
P
LP
D
V
V
H
F
-
H
D
W
H
T
V
F
A
G
A
L
I
K
K
-------
Y
F
K
I
P
A
V
F
T
I
H
R
L
N
-
K
S
K
L
P
A
F
Y
F
H
E
A
G
-------
L
S
E
L
-
A
P
Y
P
------
D
--
I
---
D
---
P
E
H
T
G
---------------
G
Y
I
A
-
D
I
V
T
T
V
S
R
G
Y
----
L
I
D
E
--
W
-
G
-----
F
F
R
--
N
F
E
G
K
---
I
T
Y
V
F
N
G
I
D
C
S
F
W
---
N
E
S
Y
L
T
G
S
R
D
---------
E
R
K
K
S
L
L
S
K
F
G
M
D
E
G
V
T
F
M
F
I
G
R
F
D
R
--
G
Q
K
G
V
D
V
L
L
K
A
I
E
I
L
S
S
K
K
E
F
Q
E
M
R
F
I
I
I
G
K
G
D
P
E
L
E
G
W
A
R
S
L
E
E
K
H
G
N
V
K
V
I
--
T
E
M
-
L
S
R
E
F
V
R
E
L
Y
G
-
S
V
D
F
V
I
I
P
S
Y
F
E
P
F
G
L
V
A
L
E
A
M
C
L
G
A
I
P
I
A
S
A
V
G
G
L
R
D
I
I
-----
T
---------------------------
N
E
T
G
I
L
V
K
A
G
D
P
G
E
L
A
N
A
I
L
K
A
L
E
-
L
-
S
R
-
S
D
L
S
K
F
R
E
N
C
K
K
R
A
M
S
--
F
S
W
E
K
S
A
E
R
Y
V
K
A
Y
------------
13
PsiBlast_PDB
66.75
27%
-35
- C2 -
3L01
9
?
A:
[3-427]
M
K
V
L
L
L
G
F
E
F
L
P
-
V
K
V
G
G
L
A
E
A
L
T
A
I
S
E
A
L
A
S
L
G
H
E
V
L
V
F
T
P
S
H
--
G
----------
R
F
Q
G
E
E
I
G
---
K
I
R
V
F
G
E
E
V
-
Q
V
K
V
S
Y
E
E
R
-----
G
N
L
R
I
Y
R
I
G
G
G
L
-
L
D
S
-------
E
-------
D
V
Y
------
G
-----
P
----
G
---------
W
D
G
L
I
R
K
A
V
T
F
G
----
R
A
S
V
----
L
L
L
N
D
--
L
L
R
------
E
------
E
----------
P
LP
D
V
V
H
F
-
H
D
W
H
T
V
F
A
G
A
L
I
K
K
-------
Y
F
K
I
P
A
V
F
T
I
H
R
L
N
-
K
S
K
L
P
A
F
Y
F
H
E
A
G
-------
L
S
E
L
-
A
P
Y
P
------
D
--
I
---
D
---
P
E
H
T
G
---------------
G
Y
I
A
-
D
I
V
T
T
V
S
R
G
Y
----
L
I
D
E
--
W
-
G
-----
F
F
R
--
N
F
E
G
K
---
I
T
Y
V
F
N
G
I
D
C
S
F
W
---
N
E
S
Y
L
T
G
S
R
D
---------
E
R
K
K
S
L
L
S
K
F
G
M
D
E
G
V
T
F
M
F
I
G
R
F
D
R
--
G
Q
K
G
V
D
V
L
L
K
A
I
E
I
L
S
S
K
K
E
F
Q
E
M
R
F
I
I
I
G
K
G
D
P
E
L
E
G
W
A
R
S
L
E
E
K
H
G
N
V
K
V
I
--
T
E
M
-
L
S
R
E
F
V
R
E
L
Y
G
-
S
V
D
F
V
I
I
P
S
Y
F
E
P
F
G
L
V
A
L
E
A
M
C
L
G
A
I
P
I
A
S
A
V
G
G
L
R
D
I
I
-----
T
---------------------------
N
E
T
G
I
L
V
K
A
G
D
P
G
E
L
A
N
A
I
L
K
A
L
E
-
L
-
S
R
-
S
D
L
S
K
F
R
E
N
C
K
K
R
A
M
S
--
F
S
W
E
K
S
A
E
R
Y
V
K
A
Y
------------
15
PsiBlast_PDB
65.12
27%
-30
- C2 -
2BIS
8
?
A:
[4-428]
M
K
V
L
L
L
G
F
E
F
L
P
-
V
K
V
G
G
L
A
E
A
L
T
A
I
S
E
A
L
A
S
L
G
H
E
V
L
V
F
T
P
S
H
--
G
----------
R
F
Q
G
E
E
I
G
---
K
I
R
V
F
G
E
E
V
-
Q
V
K
V
S
Y
E
E
R
-----
G
N
L
R
I
Y
R
I
G
G
G
L
-
L
D
S
-------
E
-------
D
V
Y
------
G
-----
P
----
G
---------
W
D
G
L
I
R
K
A
V
T
F
G
----
R
A
S
V
----
L
L
L
N
D
--
L
L
R
------
E
------
E
----------
P
LP
D
V
V
H
F
-
H
D
W
H
T
V
F
A
G
A
L
I
K
K
-------
Y
F
K
I
P
A
V
F
T
I
H
R
L
N
-
K
S
K
L
P
A
F
Y
F
H
E
A
G
-------
L
S
E
L
-
A
P
Y
P
------
D
--
I
---
D
---
P
E
H
T
G
---------------
G
Y
I
A
-
D
I
V
T
T
V
S
R
G
Y
----
L
I
D
E
--
W
-
G
-----
F
F
R
--
N
F
E
G
K
---
I
T
Y
V
F
N
G
I
D
C
S
F
W
---
N
E
S
Y
L
T
G
S
R
D
---------
E
R
K
K
S
L
L
S
K
F
G
M
D
E
G
V
T
F
M
F
I
G
R
F
D
R
--
G
Q
K
G
V
D
V
L
L
K
A
I
E
I
L
S
S
K
K
E
F
Q
E
M
R
F
I
I
I
G
K
G
D
P
E
L
E
G
W
A
R
S
L
E
-
E
K
H
G
N
V
K
V
--
I
T
E
M
L
S
R
E
F
V
R
E
L
Y
G
-
S
V
D
F
V
I
I
P
S
Y
F
E
P
F
G
L
V
A
L
E
A
M
C
L
G
A
I
P
I
A
S
A
V
G
G
L
R
D
I
I
-----
T
---------------------------
N
E
T
G
I
L
V
K
A
G
D
P
G
E
L
A
N
A
I
L
K
A
L
E
-
L
-
S
R
-
S
D
L
S
K
F
R
E
N
C
K
K
R
A
M
S
--
F
S
W
E
K
S
A
E
R
Y
V
K
A
Y
------------