@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu31050: (2016-07-21 )
MTLNMKVESMQKFHTFEIPTVIKHGIGAIKHTGEEVAALGVSKALLVTDPGIYKAGVADPVIESLKEAGIEVVLFNKVEPNPPVRLVNEGSELYKKENCNGLVAVGGGSSMDTAKAIGVEATHEGSVLDYEAADGKKPLENRIPPLTTIPTTAGTGSEVTQWAVITDEEREFKFNTGGPLIAAHLTIIDPELHVSMPPHVTAMTGIDALAHAIECYTMKFAQPITDAVALMAIEYAAHYIKRAFADGEDLEARYGMAQAAMLAGLSYGSESAGAAHAMSQTLGGIIPVAHGQCVAAMMGPVMEYNWKGYPEKFARIAKAFGIDTSKMTTEEAAKASVNWMYDLVEDLEVPTLEEQGVSPDMIERLSKEAMKDPQTFGNPRDLNEKAYNWIYKRCFNLTPKTV
Atome Classification :
(23 SA)
.........10........20........30........40.......-.50.-.-......60........70........80........90........100.......110.......120...-....130..-.....140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350-........360.......370.......380.......390.......400
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTL
N
M
K
V
E
S
M
Q
KFHTFE
I
P
T
V
I
K
H
G
I
G
A
IKHT
G
E
E
V
A
A
LGV
S
K
A
L
L
VT-DPGI-Y-KAGV
A
D
P
V
I
E
S
L
K
EAG
I
E
V
V
L
FNKVEPNP
P
V
R
L
VNE
G
S
E
L
Y
KKENC
N
G
L
V
A
VGGGSSMDT
A
K
A
IG
V
E
ATHEG-
S
V
L
D
YEAAD-GKKP
L
E
NRIPPLTTIPTTAGTGSE
V
T
Q
W
A
V
ITDEE
R
E
F
KFNTGG
P
L
I
A
A
H
L
T
I
IDP
E
L
H
VSMPP
H
V
T
A
M
T
G
I
D
A
L
A
H
A
I
E
C
Y
T
M
K
FAQ
P
I
T
D
A
V
A
L
M
A
I
E
Y
A
A
H
Y
I
K
R
AFADG
E
D
L
E
A
R
Y
G
M
A
Q
A
A
M
L
A
G
LSYGSESAG
A
A
H
A
M
S
Q
T
LG
G
I
I
PVAH
G
Q
C
V
A
A
M
MG
P
V
MEYNWKGY
P
E
K
F
A
R
I
A
K
A
FGIDTSKM
T
T
E
E
A
A
K
A
S
V
N
W
M
Y
D
L
V
E
DLEVP-
T
-
L
EEQGV
S
P
D
M
I
E
R
L
S
K
E
AMKDPQTFGNPRDL
N
E
K
A
Y
N
W
I
Y
K
R
C
FNLTPKTV
62
HHSearch
94.73
39%
-80
- C4 -
3BFJ
1
DHAT_KLEPN
A:
[4-387]
-----------
R
M
F
D
Y
L
V
P
N
V
N
F
F
G
P
N
A
I
S
V
V
G
E
R
C
Q
L
L
G
G
K
K
A
L
L
V
T
-
D
K
G
L
-
R
-
K
D
G
A
V
D
K
T
L
H
Y
L
R
E
A
G
I
E
V
A
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
A
T
H
E
G
-
D
L
Y
Q
Y
A
G
I
---
E
T
L
-
T
N
P
L
P
P
I
V
A
V
N
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
S
N
L
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
I
A
N
P
E
K
F
A
D
I
A
E
L
M
G
E
N
I
T
G
L
S
T
L
D
A
A
E
K
A
I
A
A
I
T
R
L
S
M
D
I
G
I
P
-
Q
H
L
R
D
L
G
V
K
E
T
D
F
P
Y
M
A
E
M
A
L
K
D
G
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
A
F
-------
60
HHSearch
90.39
36%
-81
- C4 -
3OX4
2
ADH2_ZYMMO
A:
[2-383]
-----------
A
S
S
T
F
Y
I
P
F
V
N
E
M
G
E
G
S
L
E
K
A
I
K
D
L
N
G
S
G
F
K
N
A
L
I
V
S
-
D
A
F
M
-
N
-
K
S
G
V
V
K
Q
V
A
D
L
L
K
A
Q
G
I
N
S
A
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
A
L
V
A
T
N
G
G
-
E
V
K
D
Y
E
G
I
---
D
K
S
-
K
K
P
A
L
P
L
M
S
I
N
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
T
P
I
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
T
A
C
D
N
G
K
D
M
P
A
R
E
A
M
A
Y
A
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
V
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
S
V
V
A
G
R
L
K
D
V
G
V
A
M
G
L
D
I
A
N
L
G
D
K
E
G
A
E
A
T
I
Q
A
V
R
D
L
A
A
S
I
G
I
P
-
A
N
L
T
E
L
G
A
K
K
E
D
V
P
L
L
A
D
H
A
L
K
D
A
C
A
L
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
L
S
A
F
-------
59
HHSearch
89.83
33%
-85
- C4 -
5BR4
6
FUCO_ECOLI
A:
[1-385]
----------
M
M
A
N
R
M
I
L
N
E
T
A
W
F
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
Y
Q
K
A
L
I
V
T
-
D
K
T
L
-
V
-
Q
C
G
V
V
A
K
V
T
D
K
M
D
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
E
-
F
-
A
D
V
R
S
L
E
-
G
L
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
C
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
G
--
D
K
D
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
R
V
M
G
V
K
V
E
G
M
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
-
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
W
L
E
-----
46
PsiBlast_CBE
87.54
35%
-92
- C4 -
2BL4
2
FUCO_ECOLI
B:
[24-378]
------------------------
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
Y
Q
K
A
L
I
V
T
-
D
K
T
L
-
V
-
Q
C
G
V
V
A
K
V
T
D
K
M
D
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
-
I
S
N
N
P
-
E
F
A
D
V
R
S
L
E
-
G
L
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
G
--
D
K
D
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
R
V
M
G
V
K
V
E
G
M
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
-
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
---------------------
5
PsiBlast_PDB
87.07
35%
-95
- C4 -
2BI4
3
FUCO_ECOLI
A:
[24-378]
------------------------
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
Y
Q
K
A
L
I
V
T
-
D
K
T
L
-
V
-
Q
C
G
V
V
A
K
V
T
D
K
M
D
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
-
I
S
N
N
P
-
E
F
A
D
V
R
S
L
E
-
G
L
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
G
--
D
K
D
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
R
V
M
G
V
K
V
E
G
M
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
-
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
---------------------
21
PsiBlast_CBE
86.03
39%
-11
- C4 -
3BFJ
14
DHAT_KLEPN
T:
[4-387]
-----------
R
M
F
D
Y
L
V
P
N
V
N
F
F
G
P
N
A
I
S
V
V
G
E
R
C
Q
L
L
G
G
K
K
A
L
L
V
T
-
D
K
G
L
R--
K
D
G
A
V
D
K
T
L
H
Y
L
R
E
A
G
I
E
V
A
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
A
T
H
E
G
-
D
L
Y
Q
Y
A
----
G
I
E
T
L
T
N
P
L
P
P
I
V
A
V
N
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
S
N
L
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
I
A
N
P
E
K
F
A
D
I
A
E
L
M
G
E
N
I
T
G
L
S
T
L
D
A
A
E
K
A
I
A
A
I
T
R
L
S
M
D
I
G
I
P
-
Q
H
L
R
D
L
G
V
K
E
T
D
F
P
Y
M
A
E
M
A
L
K
D
G
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
A
F
-------
6
PsiBlast_PDB
85.90
35%
-90
- C4 -
2BL4
3
FUCO_ECOLI
A:
[24-378]
------------------------
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
Y
Q
K
A
L
I
V
T
-
D
K
T
L
-
V
-
Q
C
G
V
V
A
K
V
T
D
K
M
D
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
-
I
S
N
N
P
-
E
F
A
D
V
R
S
L
E
-
G
L
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
G
--
D
K
D
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
R
V
M
G
V
K
V
E
G
M
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
-
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
---------------------
8
PsiBlast_PDB
85.53
34%
-85
- C4 -
1RRM
4
FUCO_ECOLI
A:
[15-369]
------------------------
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
Y
Q
K
A
L
I
V
T
-
D
K
T
L
-
V
-
Q
C
G
V
V
A
K
V
T
D
K
M
D
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
-
I
S
N
N
P
-
E
F
A
D
V
R
S
L
E
-
G
L
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
G
D
K
D
A
G
E
E
M
A
L
G
Q
--
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
R
V
M
G
V
K
V
E
G
M
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
-
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
---------------------
36
PsiBlast_CBE
85.40
39%
-12
- C4 -
3BFJ
1
DHAT_KLEPN
E:
[4-387]
-----------
R
M
F
D
Y
L
V
P
N
V
N
F
F
G
P
N
A
I
S
V
V
G
E
R
C
Q
L
L
G
G
K
K
A
L
L
V
T
-
D
K
G
L
R--
K
D
G
A
V
D
K
T
L
H
Y
L
R
E
A
G
I
E
V
A
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
A
T
H
E
G
-
D
L
Y
Q
Y
A
----
G
I
E
T
L
T
N
P
L
P
P
I
V
A
V
N
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
S
N
L
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
I
A
N
P
E
K
F
A
D
I
A
E
L
M
G
E
N
I
T
G
L
S
T
L
D
A
A
E
K
A
I
A
A
I
T
R
L
S
M
D
I
G
I
P
-
Q
H
L
R
D
L
G
V
K
E
T
D
F
P
Y
M
A
E
M
A
L
K
D
G
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
A
F
-------
7
PsiBlast_PDB
85.34
35%
-91
- C4 -
5BR4
6
FUCO_ECOLI
A:
[15-369]
------------------------
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
Y
Q
K
A
L
I
V
T
-
D
K
T
L
-
V
-
Q
C
G
V
V
A
K
V
T
D
K
M
D
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
-
I
S
N
N
P
-
E
F
A
D
V
R
S
L
E
-
G
L
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
C
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
G
--
D
K
D
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
R
V
M
G
V
K
V
E
G
M
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
-
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
---------------------
47
PsiBlast_CBE
84.99
35%
-92
- C4 -
2BI4
2
FUCO_ECOLI
B:
[24-378]
------------------------
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
Y
Q
K
A
L
I
V
T
-
D
K
T
L
-
V
-
Q
C
G
V
V
A
K
V
T
D
K
M
D
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
-
I
S
N
N
P
-
E
F
A
D
V
R
S
L
E
-
G
L
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
G
--
D
K
D
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
R
V
M
G
V
K
V
E
G
M
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
-
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
---------------------
48
PsiBlast_CBE
84.98
35%
-91
- C4 -
5BR4
6
FUCO_ECOLI
B:
[15-369]
------------------------
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
Y
Q
K
A
L
I
V
T
-
D
K
T
L
-
V
-
Q
C
G
V
V
A
K
V
T
D
K
M
D
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
-
I
S
N
N
P
-
E
F
A
D
V
R
S
L
E
-
G
L
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
C
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
G
--
D
K
D
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
R
V
M
G
V
K
V
E
G
M
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
-
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
---------------------
1
PsiBlast_PDB
84.81
39%
-11
- C4 -
3BFJ
1
DHAT_KLEPN
A:
[4-387]
-----------
R
M
F
D
Y
L
V
P
N
V
N
F
F
G
P
N
A
I
S
V
V
G
E
R
C
Q
L
L
G
G
K
K
A
L
L
V
T
-
D
K
G
L
R--
K
D
G
A
V
D
K
T
L
H
Y
L
R
E
A
G
I
E
V
A
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
A
T
H
E
G
-
D
L
Y
Q
Y
A
----
G
I
E
T
L
T
N
P
L
P
P
I
V
A
V
N
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
S
N
L
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
I
A
N
P
E
K
F
A
D
I
A
E
L
M
G
E
N
I
T
G
L
S
T
L
D
A
A
E
K
A
I
A
A
I
T
R
L
S
M
D
I
G
I
P
-
Q
H
L
R
D
L
G
V
K
E
T
D
F
P
Y
M
A
E
M
A
L
K
D
G
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
A
F
-------
38
PsiBlast_CBE
84.79
39%
-10
- C4 -
3BFJ
1
DHAT_KLEPN
C:
[4-387]
-----------
R
M
F
D
Y
L
V
P
N
V
N
F
F
G
P
N
A
I
S
V
V
G
E
R
C
Q
L
L
G
G
K
K
A
L
L
V
T
-
D
K
G
L
R--
K
D
G
A
V
D
K
T
L
H
Y
L
R
E
A
G
I
E
V
A
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
A
T
H
E
G
-
D
L
Y
Q
Y
A
----
G
I
E
T
L
T
N
P
L
P
P
I
V
A
V
N
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
S
N
L
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
I
A
N
P
E
K
F
A
D
I
A
E
L
M
G
E
N
I
T
G
L
S
T
L
D
A
A
E
K
A
I
A
A
I
T
R
L
S
M
D
I
G
I
P
-
Q
H
L
R
D
L
G
V
K
E
T
D
F
P
Y
M
A
E
M
A
L
K
D
G
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
A
F
-------
37
PsiBlast_CBE
84.60
39%
-11
- C4 -
3BFJ
1
DHAT_KLEPN
D:
[4-387]
-----------
R
M
F
D
Y
L
V
P
N
V
N
F
F
G
P
N
A
I
S
V
V
G
E
R
C
Q
L
L
G
G
K
K
A
L
L
V
T
-
D
K
G
L
R--
K
D
G
A
V
D
K
T
L
H
Y
L
R
E
A
G
I
E
V
A
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
A
T
H
E
G
-
D
L
Y
Q
Y
A
----
G
I
E
T
L
T
N
P
L
P
P
I
V
A
V
N
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
S
N
L
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
I
A
N
P
E
K
F
A
D
I
A
E
L
M
G
E
N
I
T
G
L
S
T
L
D
A
A
E
K
A
I
A
A
I
T
R
L
S
M
D
I
G
I
P
-
Q
H
L
R
D
L
G
V
K
E
T
D
F
P
Y
M
A
E
M
A
L
K
D
G
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
A
F
-------
39
PsiBlast_CBE
84.48
39%
-11
- C4 -
3BFJ
1
DHAT_KLEPN
B:
[4-387]
-----------
R
M
F
D
Y
L
V
P
N
V
N
F
F
G
P
N
A
I
S
V
V
G
E
R
C
Q
L
L
G
G
K
K
A
L
L
V
T
-
D
K
G
L
R--
K
D
G
A
V
D
K
T
L
H
Y
L
R
E
A
G
I
E
V
A
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
A
T
H
E
G
-
D
L
Y
Q
Y
A
----
G
I
E
T
L
T
N
P
L
P
P
I
V
A
V
N
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
S
N
L
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
I
A
N
P
E
K
F
A
D
I
A
E
L
M
G
E
N
I
T
G
L
S
T
L
D
A
A
E
K
A
I
A
A
I
T
R
L
S
M
D
I
G
I
P
-
Q
H
L
R
D
L
G
V
K
E
T
D
F
P
Y
M
A
E
M
A
L
K
D
G
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
A
F
-------
40
PsiBlast_CBE
84.46
37%
-33
- C4 -
3OX4
2
ADH2_ZYMMO
D:
[5-383]
--------------
T
F
Y
I
P
F
V
N
E
M
G
E
G
S
L
E
K
A
I
K
D
L
N
G
S
G
F
K
N
A
L
I
V
S
-
D
A
F
M
-
N
-
K
S
G
V
V
K
Q
V
A
D
L
L
K
A
Q
G
I
N
S
A
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
A
L
V
A
T
N
G
G
-
E
V
K
D
Y
E
G
I
D
K
S
K
K
P
----
A
L
P
L
M
S
I
N
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
T
P
I
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
T
A
C
D
N
G
K
D
M
P
A
R
E
A
M
A
Y
A
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
V
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
S
V
V
A
G
R
L
K
D
V
G
V
A
M
G
L
D
I
A
N
L
G
D
K
E
G
A
E
A
T
I
Q
A
V
R
D
L
A
A
S
I
G
I
P
A
N
-
L
T
E
L
G
A
K
K
E
D
V
P
L
L
A
D
H
A
L
K
D
A
C
A
L
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
L
S
A
F
-------
35
PsiBlast_CBE
84.18
39%
-11
- C4 -
3BFJ
1
DHAT_KLEPN
F:
[4-387]
-----------
R
M
F
D
Y
L
V
P
N
V
N
F
F
G
P
N
A
I
S
V
V
G
E
R
C
Q
L
L
G
G
K
K
A
L
L
V
T
-
D
K
G
L
R--
K
D
G
A
V
D
K
T
L
H
Y
L
R
E
A
G
I
E
V
A
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
A
T
H
E
G
-
D
L
Y
Q
Y
A
----
G
I
E
T
L
T
N
P
L
P
P
I
V
A
V
N
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
S
N
L
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
I
A
N
P
E
K
F
A
D
I
A
E
L
M
G
E
N
I
T
G
L
S
T
L
D
A
A
E
K
A
I
A
A
I
T
R
L
S
M
D
I
G
I
P
-
Q
H
L
R
D
L
G
V
K
E
T
D
F
P
Y
M
A
E
M
A
L
K
D
G
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
A
F
-------
45
PsiBlast_CBE
83.46
37%
-30
- C4 -
3OWO
1
ADH2_ZYMMO
B:
[5-383]
--------------
T
F
Y
I
P
F
V
N
E
M
G
E
G
S
L
E
K
A
I
K
D
L
N
G
S
G
F
K
N
A
L
I
V
S
-
D
A
F
M
-
N
-
K
S
G
V
V
K
Q
V
A
D
L
L
K
A
Q
G
I
N
S
A
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
A
L
V
A
T
N
G
G
-
E
V
K
D
Y
E
G
I
D
K
S
K
K
P
----
A
L
P
L
M
S
I
N
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
T
P
I
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
T
A
C
D
N
G
K
D
M
P
A
R
E
A
M
A
Y
A
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
V
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
S
V
V
A
G
R
L
K
D
V
G
V
A
M
G
L
D
I
A
N
L
G
D
K
E
G
A
E
A
T
I
Q
A
V
R
D
L
A
A
S
I
G
I
P
A
N
-
L
T
E
L
G
A
K
K
E
D
V
P
L
L
A
D
H
A
L
K
D
A
C
A
L
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
L
S
A
F
-------
42
PsiBlast_CBE
83.35
37%
-32
- C4 -
3OX4
2
ADH2_ZYMMO
B:
[5-383]
--------------
T
F
Y
I
P
F
V
N
E
M
G
E
G
S
L
E
K
A
I
K
D
L
N
G
S
G
F
K
N
A
L
I
V
S
-
D
A
F
M
-
N
-
K
S
G
V
V
K
Q
V
A
D
L
L
K
A
Q
G
I
N
S
A
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
A
L
V
A
T
N
G
G
-
E
V
K
D
Y
E
G
I
D
K
S
K
K
P
----
A
L
P
L
M
S
I
N
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
T
P
I
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
T
A
C
D
N
G
K
D
M
P
A
R
E
A
M
A
Y
A
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
V
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
S
V
V
A
G
R
L
K
D
V
G
V
A
M
G
L
D
I
A
N
L
G
D
K
E
G
A
E
A
T
I
Q
A
V
R
D
L
A
A
S
I
G
I
P
A
N
-
L
T
E
L
G
A
K
K
E
D
V
P
L
L
A
D
H
A
L
K
D
A
C
A
L
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
L
S
A
F
-------
65
HHSearch
65.32
30%
9
- C4 -
1O2D
3
?
A:
[15-370]
--------------
E
F
Y
M
P
T
D
V
F
F
G
E
K
I
L
E
K
R
G
N
I
I
D
L
L
G
-
K
R
A
L
V
V
T
-
G
K
S
S
-
S
K
K
N
G
S
L
D
D
L
K
K
L
L
D
E
T
E
I
S
Y
E
I
F
D
E
V
E
E
N
P
S
F
D
N
V
M
K
A
V
E
R
Y
R
N
D
S
F
D
F
V
V
G
L
G
G
G
S
P
M
D
F
A
K
A
V
A
V
L
L
K
E
K
D
L
S
V
E
D
L
Y
D
R
--
E
--
K
-
V
K
H
W
L
P
V
V
E
I
P
T
T
A
G
T
G
S
E
V
T
P
Y
S
I
L
T
D
P
E
-
G
N
K
R
G
C
--
T
L
M
F
P
V
Y
A
F
L
D
P
R
Y
T
Y
S
M
S
D
E
L
T
L
S
T
G
V
D
A
L
S
H
A
V
E
G
Y
L
S
R
K
S
T
P
P
S
D
A
L
A
I
E
A
M
K
I
I
H
R
N
L
P
K
A
I
E
G
--
N
R
E
A
R
K
K
M
F
V
A
S
C
L
A
G
M
V
I
A
Q
T
G
T
T
L
A
H
A
L
G
Y
P
L
T
T
E
K
G
I
K
H
G
K
A
T
G
M
V
L
P
F
V
M
E
V
M
K
E
E
I
P
E
K
V
D
T
V
N
H
I
F
G
G
----------------
S
L
L
K
F
L
K
E
L
G
L
Y
-
E
K
V
---
A
V
S
S
E
E
L
E
K
W
V
E
K
G
S
R
A
K
H
L
K
N
T
P
G
T
F
T
P
E
K
I
R
N
I
Y
R
E
A
L
G
------
10
PsiBlast_PDB
58.38
30%
-23
- C4 -
1O2D
3
?
A:
[16-313]
---------------
F
Y
M
P
T
D
V
F
F
G
E
K
I
L
E
K
R
G
N
I
I
D
L
L
G
-
K
R
A
L
V
V
T
G
K
S
S
S
-
K
-
K
N
G
S
L
D
D
L
K
K
L
L
D
E
T
E
I
S
Y
E
I
F
D
E
V
E
E
N
P
S
F
D
N
V
M
K
A
V
E
R
Y
R
N
D
S
F
D
F
V
V
G
L
G
G
G
S
P
M
D
F
A
K
A
V
A
V
L
L
K
E
K
D
---
L
S
V
E
D
L
Y
-
D
R
E
K
V
K
H
W
L
-
P
V
V
E
I
P
T
T
A
G
T
G
S
E
V
T
P
Y
S
I
L
T
D
P
E
G
N
---
K
R
G
C
T
L
M
F
P
V
Y
A
F
L
D
P
R
Y
T
Y
S
M
S
D
E
L
T
L
S
T
G
V
D
A
L
S
H
A
V
E
G
Y
L
S
R
K
S
T
P
P
S
D
A
L
A
I
E
A
M
K
I
I
H
R
N
L
P
K
A
I
E
G
N
R
--
E
A
R
K
K
M
F
V
A
S
C
L
A
G
M
V
I
A
Q
T
G
T
T
L
A
H
A
L
G
Y
P
L
T
T
E
K
G
I
K
H
G
K
A
T
G
M
V
L
P
F
V
M
E
V
M
K
E
E
I
P
E
K
V
D
T
V
N
H
I
F
G
-----------------------------------------------------------------------------------
11
PsiBlast_PDB
58.17
30%
-22
- C4 -
1VHD
3
?
A:
[6-303]
---------------
F
Y
M
P
T
D
V
F
F
G
E
K
I
L
E
K
R
G
N
I
I
D
L
L
G
-
K
R
A
L
V
V
T
G
K
S
S
S
-
K
-
K
N
G
S
L
D
D
L
K
K
L
L
D
E
T
E
I
S
Y
E
I
F
D
E
V
E
E
N
P
S
F
D
N
V
M
K
A
V
E
R
Y
R
N
D
S
F
D
F
V
V
G
L
G
G
G
S
P
M
D
F
A
K
A
V
A
V
L
L
K
E
K
D
---
L
S
V
E
D
L
Y
-
D
R
E
K
V
K
H
W
L
-
P
V
V
E
I
P
T
T
A
G
T
G
S
E
V
T
P
Y
S
I
L
T
D
P
E
G
N
---
K
R
G
C
T
L
M
F
P
V
Y
A
F
L
D
P
R
Y
T
Y
S
M
S
D
E
L
T
L
S
T
G
V
D
A
L
S
H
A
V
E
G
Y
L
S
R
K
S
T
P
P
S
D
A
L
A
I
E
A
M
K
I
I
H
R
N
L
P
K
A
I
E
G
--
N
R
E
A
R
K
K
M
F
V
A
S
C
L
A
G
M
V
I
A
Q
T
G
T
T
L
A
H
A
L
G
Y
P
L
T
T
E
K
G
I
K
H
G
K
A
T
G
M
V
L
P
F
V
M
E
V
M
K
E
E
I
P
E
K
V
D
T
V
N
H
I
F
G
-----------------------------------------------------------------------------------