@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu31220: (2016-07-21 )
MVKHIWDSERAAQLPKGVEELVYRSNLIGSDRTVCNWGGGNTSMKTTEKDFRGREIEVMWVKGSGSDLATMKAHNFSGLKLDDIRPLIKRDQMPDEEMVDYLSHCMIDSKHPRPSIETLLHAFLPYKHVDHTHPDAIISICCADNGKQIAEDIYGNRFVWVPYVRPGFTLSKMIAEGVANNPHAELVLMEKHGLVTWGETSETCYQKTISIIQEAEQYINDRINQHEVFGGKRYQPLPEDKRKQILAGIMPVIRGAVSEEKKMILSYDDHDDVLEFVNSVQAPALSQIGAACPDHLVHTKRVPLYIDWNPETQDVHKLADLIKSGVETFTSEYQAYFTRNQQDGDQIFESAPRVILIPGIGMVNTGKSYAMSKVSGALYRRAIAVMKGATALGQFVSLHENESYHVEYWPLELYKLTLAPPEAEFSRKVALITGGAGGIGSAACRRFAAEGGHVIVADLNIEGAQKIAGEINDAYGKGRAMAVKMDVTKEEDVQSAFERAALAYGGIDIVVNNAGLATSSPFDETSLKEWNLNMNVLGTGYFLVAREAFKQMKHQNRGGSMVFVGSKNSVYAGKNASAYSSVKALETHLARCIAAEGGEFGIRVNSVLPDAVLQGSAIWGSSWREERAAAYGIEPDQLEEHYRKRTALLVNIYPEDIAEAIAFFASSKAEKTTGCMITVDGGVPAAFTR
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520....--...530.......540.-......550.......560.......570.......580.......590.......600.......610.......620.......630.-....-..640.......650.......660.......670.......680.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MVKHIWD
S
E
R
A
A
Q
L
P
K
G
V
E
E
L
V
Y
R
SNLIGSDR
T
V
C
NWGGGNTSMKTTEKDFRG
R
E
I
E
V
M
W
VKGSGS
D
L
A
T
M
K
AHNFSGL
K
L
D
D
I
R
P
L
I
K
RDQMP
D
E
E
M
V
D
Y
L
S
H
CMIDSKHPR
P
S
I
E
T
L
L
H
A
FLPYKHVDHTHPD
A
I
I
S
I
C
CADN
G
K
Q
I
A
E
D
IYG
N
R
F
V
W
V
PYVRPG
F
T
L
S
K
M
I
A
E
G
VANNPH
A
E
L
V
L
M
EKHG
L
V
TWGE
T
S
E
T
C
Y
Q
K
T
I
S
I
I
Q
E
A
E
Q
Y
I
N
DRI
N
Q
H
EVFGGKRYQPL
P
E
D
K
R
K
Q
I
L
A
G
I
M
P
V
I
R
G
AVSEE
K
K
M
I
L
SYDD
H
D
D
V
L
E
F
V
N
SVQA
P
A
L
S
Q
I
G
AAC
P
D
HLVHTKRV
P
L
Y
I
DWNPE
T
Q
D
V
H
K
L
A
D
L
I
K
S
G
V
E
T
F
T
S
E
Y
Q
A
Y
F
TRNQQD
G
D
Q
I
F
E
SAP
R
V
I
L
I
PGIGMVNTG
K
S
Y
A
M
S
K
V
S
G
A
L
Y
R
R
A
I
A
V
MK
G
A
T
A
L
G
Q
F
V
S
LHENE
S
Y
H
V
E
Y
W
P
L
E
L
Y
K
L
TLAPP
E
A
E
F
S
R
K
V
A
L
I
TGGAGG
I
G
S
A
A
C
R
R
F
A
AEGG
H
V
I
V
A
DLNIE
G
A
Q
K
I
A
G
E
I
N
D
AYGKG
R
A
M
A
V
K
MDVT
K
E
E
D
V
Q
S
A
F
E
R
A
A
L
AYG
G
I
D
I
V
VNNAGLATSSPFDETS--LKEWNL
N
M
N
V
LGT
G
Y
F
L
-
V
A
R
E
A
F
K
Q
M
K
HQNRGG
S
M
V
F
VGSKNSVYAGKNA
S
A
Y
S
S
V
K
A
L
E
T
H
L
A
R
C
I
AAEGG
E
F
G
I
R
V
NSVL
P
D
A
V
LQGSAIWGSS
W
R
E
E
R
AAAYGI-
E
P
D
Q
-
L
E
E
H
Y
R
K
R
T
A
L
L
V
N
I
Y
P
E
D
I
A
E
A
I
A
F
F
ASSKAEKTT
G
C
M
I
T
VDGGVPAAFTR
42
PsiBlast_CBE
87.39
33%
0
- C- -
1GEG
2
BUDC_KLEPN
B:
[2-253]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
V
A
L
V
T
G
A
G
Q
G
I
G
K
A
I
A
L
R
L
V
K
D
G
F
A
V
A
I
A
D
Y
N
D
A
T
A
K
A
V
A
S
E
I
N
Q
A
--
G
G
H
A
V
A
V
K
V
D
V
S
D
R
D
Q
V
F
A
A
V
E
Q
A
R
K
T
L
G
G
F
D
V
I
V
N
N
A
G
V
A
P
S
T
P
I
E
S
I
T
P
E
I
V
D
K
V
Y
N
I
N
V
K
G
V
I
W
G
I
Q
A
A
V
E
A
F
K
K
E
G
H
---
G
G
K
I
I
N
A
C
S
Q
A
G
H
V
G
N
P
E
L
A
V
Y
S
S
S
K
F
A
V
R
G
L
T
Q
T
A
A
R
D
L
A
P
L
G
I
T
V
N
G
Y
C
P
G
I
V
K
--
T
P
M
W
A
E
I
D
R
Q
V
S
E
A
A
-
G
K
-
P
L
G
Y
-
G
T
A
E
F
A
K
R
I
T
L
G
R
L
S
E
P
E
D
V
A
A
C
V
S
Y
L
A
S
P
D
S
D
Y
M
T
G
Q
S
L
L
I
D
G
G
M
------
41
PsiBlast_CBE
87.39
33%
0
- C- -
1GEG
2
BUDC_KLEPN
C:
[2-253]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
V
A
L
V
T
G
A
G
Q
G
I
G
K
A
I
A
L
R
L
V
K
D
G
F
A
V
A
I
A
D
Y
N
D
A
T
A
K
A
V
A
S
E
I
N
Q
A
--
G
G
H
A
V
A
V
K
V
D
V
S
D
R
D
Q
V
F
A
A
V
E
Q
A
R
K
T
L
G
G
F
D
V
I
V
N
N
A
G
V
A
P
S
T
P
I
E
S
I
T
PE
I
V
D
K
V
Y
N
I
N
V
K
G
V
I
W
G
I
Q
A
A
V
E
A
F
K
K
E
G
H
---
G
G
K
I
I
N
A
C
S
Q
A
G
H
V
G
N
P
E
L
A
V
Y
S
S
S
K
F
A
V
R
G
L
T
Q
T
A
A
R
D
L
A
P
L
G
I
T
V
N
G
Y
C
P
G
I
V
K
--
T
P
M
W
A
E
I
D
R
Q
V
S
E
A
A
-
G
K
-
P
L
G
Y
-
G
T
A
E
F
A
K
R
I
T
L
G
R
L
S
E
P
E
D
V
A
A
C
V
S
Y
L
A
S
P
D
S
D
Y
M
T
G
Q
S
L
L
I
D
G
G
M
------
40
PsiBlast_CBE
87.39
33%
0
- C- -
1GEG
2
BUDC_KLEPN
D:
[2-253]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
V
A
L
V
T
G
A
G
Q
G
I
G
K
A
I
A
L
R
L
V
K
D
G
F
A
V
A
I
A
D
Y
N
D
A
T
A
K
A
V
A
S
E
I
N
Q
A
--
G
G
H
A
V
A
V
K
V
D
V
S
D
R
D
Q
V
F
A
A
V
E
Q
A
R
K
T
L
G
G
F
D
V
I
V
N
N
A
G
V
A
P
S
T
P
I
E
S
I
T
PE
I
V
D
K
V
Y
N
I
N
V
K
G
V
I
W
G
I
Q
A
A
V
E
A
F
K
K
E
G
H
---
G
G
K
I
I
N
A
C
S
Q
A
G
H
V
G
N
P
E
L
A
V
Y
S
S
S
K
F
A
V
R
G
L
T
Q
T
A
A
R
D
L
A
P
L
G
I
T
V
N
G
Y
C
P
G
I
V
K
--
T
P
M
W
A
E
I
D
R
Q
V
S
E
A
A
-
G
K
-
P
L
G
Y
-
G
T
A
E
F
A
K
R
I
T
L
G
R
L
S
E
P
E
D
V
A
A
C
V
S
Y
L
A
S
P
D
S
D
Y
M
T
G
Q
S
L
L
I
D
G
G
M
------
39
PsiBlast_CBE
87.39
33%
0
- C- -
1GEG
2
BUDC_KLEPN
E:
[2-253]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
V
A
L
V
T
G
A
G
Q
G
I
G
K
A
I
A
L
R
L
V
K
D
G
F
A
V
A
I
A
D
Y
N
D
A
T
A
K
A
V
A
S
E
I
N
Q
A
--
G
G
H
A
V
A
V
K
V
D
V
S
D
R
D
Q
V
F
A
A
V
E
Q
A
R
K
T
L
G
G
F
D
V
I
V
N
N
A
G
V
A
P
S
T
P
I
E
S
I
T
PE
I
V
D
K
V
Y
N
I
N
V
K
G
V
I
W
G
I
Q
A
A
V
E
A
F
K
K
E
G
H
---
G
G
K
I
I
N
A
C
S
Q
A
G
H
V
G
N
P
E
L
A
V
Y
S
S
S
K
F
A
V
R
G
L
T
Q
T
A
A
R
D
L
A
P
L
G
I
T
V
N
G
Y
C
P
G
I
V
K
--
T
P
M
W
A
E
I
D
R
Q
V
S
E
A
A
-
G
K
-
P
L
G
Y
-
G
T
A
E
F
A
K
R
I
T
L
G
R
L
S
E
P
E
D
V
A
A
C
V
S
Y
L
A
S
P
D
S
D
Y
M
T
G
Q
S
L
L
I
D
G
G
M
------
38
PsiBlast_CBE
87.39
33%
0
- C- -
1GEG
2
BUDC_KLEPN
F:
[2-253]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
V
A
L
V
T
G
A
G
Q
G
I
G
K
A
I
A
L
R
L
V
K
D
G
F
A
V
A
I
A
D
Y
N
D
A
T
A
K
A
V
A
S
E
I
N
Q
A
--
G
G
H
A
V
A
V
K
V
D
V
S
D
R
D
Q
V
F
A
A
V
E
Q
A
R
K
T
L
G
G
F
D
V
I
V
N
N
A
G
V
A
P
S
T
P
I
E
S
I
T
PE
I
V
D
K
V
Y
N
I
N
V
K
G
V
I
W
G
I
Q
A
A
V
E
A
F
K
K
E
G
H
---
G
G
K
I
I
N
A
C
S
Q
A
G
H
V
G
N
P
E
L
A
V
Y
S
S
S
K
F
A
V
R
G
L
T
Q
T
A
A
R
D
L
A
P
L
G
I
T
V
N
G
Y
C
P
G
I
V
K
--
T
P
M
W
A
E
I
D
R
Q
V
S
E
A
A
-
G
K
-
P
L
G
Y
-
G
T
A
E
F
A
K
R
I
T
L
G
R
L
S
E
P
E
D
V
A
A
C
V
S
Y
L
A
S
P
D
S
D
Y
M
T
G
Q
S
L
L
I
D
G
G
M
------
37
PsiBlast_CBE
87.39
33%
0
- C- -
1GEG
2
BUDC_KLEPN
G:
[2-253]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
V
A
L
V
T
G
A
G
Q
G
I
G
K
A
I
A
L
R
L
V
K
D
G
F
A
V
A
I
A
D
Y
N
D
A
T
A
K
A
V
A
S
E
I
N
Q
A
--
G
G
H
A
V
A
V
K
V
D
V
S
D
R
D
Q
V
F
A
A
V
E
Q
A
R
K
T
L
G
G
F
D
V
I
V
N
N
A
G
V
A
P
S
T
P
I
E
S
I
T
PE
I
V
D
K
V
Y
N
I
N
V
K
G
V
I
W
G
I
Q
A
A
V
E
A
F
K
K
E
G
H
---
G
G
K
I
I
N
A
C
S
Q
A
G
H
V
G
N
P
E
L
A
V
Y
S
S
S
K
F
A
V
R
G
L
T
Q
T
A
A
R
D
L
A
P
L
G
I
T
V
N
G
Y
C
P
G
I
V
K
--
T
P
M
W
A
E
I
D
R
Q
V
S
E
A
A
-
G
K
-
P
L
G
Y
-
G
T
A
E
F
A
K
R
I
T
L
G
R
L
S
E
P
E
D
V
A
A
C
V
S
Y
L
A
S
P
D
S
D
Y
M
T
G
Q
S
L
L
I
D
G
G
M
------
36
PsiBlast_CBE
87.39
33%
0
- C- -
1GEG
12
BUDC_KLEPN
H:
[2-253]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
V
A
L
V
T
G
A
G
Q
G
I
G
K
A
I
A
L
R
L
V
K
D
G
F
A
V
A
I
A
D
Y
N
D
A
T
A
K
A
V
A
S
E
I
N
Q
A
--
G
G
H
A
V
A
V
K
V
D
V
S
D
R
D
Q
V
F
A
A
V
E
Q
A
R
K
T
L
G
G
F
D
V
I
V
N
N
A
G
V
A
P
S
T
P
I
E
S
I
T
PE
I
V
D
K
V
Y
N
I
N
V
K
G
V
I
W
G
I
Q
A
A
V
E
A
F
K
K
E
G
H
---
G
G
K
I
I
N
A
C
S
Q
A
G
H
V
G
N
P
E
L
A
V
Y
S
S
S
K
F
A
V
R
G
L
T
Q
T
A
A
R
D
L
A
P
L
G
I
T
V
N
G
Y
C
P
G
I
V
K
--
T
P
M
W
A
E
I
D
R
Q
V
S
E
A
A
-
G
K
-
P
L
G
Y
-
G
T
A
E
F
A
K
R
I
T
L
G
R
L
S
E
P
E
D
V
A
A
C
V
S
Y
L
A
S
P
D
S
D
Y
M
T
G
Q
S
L
L
I
D
G
G
M
------
9
PsiBlast_PDB
87.39
33%
0
- C- -
1GEG
2
BUDC_KLEPN
A:
[2-253]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
V
A
L
V
T
G
A
G
Q
G
I
G
K
A
I
A
L
R
L
V
K
D
G
F
A
V
A
I
A
D
Y
N
D
A
T
A
K
A
V
A
S
E
I
N
Q
A
--
G
G
H
A
V
A
V
K
V
D
V
S
D
R
D
Q
V
F
A
A
V
E
Q
A
R
K
T
L
G
G
F
D
V
I
V
N
N
A
G
V
A
P
S
T
P
I
E
S
I
T
P
E
I
V
D
K
V
Y
N
I
N
V
K
G
V
I
W
G
I
Q
A
A
V
E
A
F
K
K
E
G
H
---
G
G
K
I
I
N
A
C
S
Q
A
G
H
V
G
N
P
E
L
A
V
Y
S
S
S
K
F
A
V
R
G
L
T
Q
T
A
A
R
D
L
A
P
L
G
I
T
V
N
G
Y
C
P
G
I
V
K
--
T
P
M
W
A
E
I
D
R
Q
V
S
E
A
A
-
G
K
-
P
L
G
Y
-
G
T
A
E
F
A
K
R
I
T
L
G
R
L
S
E
P
E
D
V
A
A
C
V
S
Y
L
A
S
P
D
S
D
Y
M
T
G
Q
S
L
L
I
D
G
G
M
------
14
PsiBlast_PDB
86.86
32%
-93
- C2 -
3WYE
1
BUDC_CORGT (first)
A:
[2-253]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
V
A
L
V
T
G
A
G
Q
G
I
G
K
A
I
A
L
R
L
V
K
D
G
F
A
V
A
I
A
D
Y
N
D
A
T
A
K
A
V
A
S
E
I
N
Q
A
--
G
G
H
A
V
A
V
K
V
D
V
S
D
R
D
Q
V
F
A
A
V
E
Q
A
R
K
T
L
G
G
F
D
V
I
V
N
N
A
G
I
A
Q
I
K
P
L
L
E
V
T
--
E
E
D
L
K
Q
I
Y
S
V
N
V
F
S
V
F
F
-
G
I
Q
A
A
V
E
A
F
K
K
E
G
H
G
G
K
I
I
N
A
A
S
I
A
A
I
Q
G
F
P
I
L
S
A
Y
S
T
T
K
F
A
V
R
G
L
T
Q
T
A
A
R
D
L
A
P
L
G
I
T
V
N
G
Y
C
P
G
I
V
--
G
T
G
M
W
-
E
Q
I
D
A
E
L
S
K
I
N
G
K
-
P
I
G
E
-
N
F
K
E
Y
S
S
S
I
A
L
G
R
P
S
V
P
E
D
V
A
G
L
V
S
F
L
A
S
P
D
S
D
Y
M
T
G
Q
S
L
L
I
D
G
G
M
------
28
PsiBlast_CBE
86.34
32%
-103
- C2 -
2D1Y
1
?
C:
[4-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
G
K
G
V
L
V
T
G
G
A
R
G
I
G
R
A
I
A
Q
A
F
A
R
E
G
A
L
V
A
L
C
D
L
R
P
E
G
-
K
E
V
A
E
A
I
G
G
A
F
-------
F
Q
V
D
L
E
D
E
R
E
R
V
R
F
V
E
E
A
A
Y
A
L
G
R
V
D
V
L
V
N
N
A
A
I
A
A
P
G
S
A
L
T
V
R
--
L
P
E
W
R
R
V
L
E
V
N
L
T
A
P
M
H
-
L
S
A
L
A
A
R
E
M
R
K
V
G
-
G
G
A
I
V
N
V
A
S
V
Q
G
L
F
A
E
Q
E
N
A
A
Y
N
A
S
K
G
G
L
V
N
L
T
R
S
L
A
L
D
L
A
P
L
R
I
R
V
N
A
V
A
P
G
A
I
A
T
E
A
V
L
--------
E
A
I
A
L
S
P
-
D
P
E
R
-
T
R
R
D
W
E
D
L
H
A
L
R
R
L
G
K
P
E
E
V
A
E
A
V
L
F
L
A
S
E
K
A
S
F
I
T
G
A
I
L
P
V
D
G
G
M
T
A
S
F
--
25
PsiBlast_CBE
85.33
32%
-88
- C2 -
4TRR
2
?
C:
[10-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
L
N
G
K
T
A
V
V
T
G
A
A
S
G
I
G
K
E
I
A
L
E
L
A
K
A
G
A
A
V
A
I
A
D
L
N
Q
D
G
A
N
A
V
A
D
E
I
N
K
A
G
G
K
--
A
I
G
V
A
M
D
V
T
N
E
E
A
V
N
T
G
I
D
K
V
A
E
A
F
G
S
V
D
I
L
V
S
N
A
G
I
Q
I
V
N
P
I
E
N
Y
S
--
F
A
D
W
K
K
M
Q
A
I
H
V
D
G
A
F
L
-
T
T
K
A
A
L
K
H
M
Y
K
D
D
R
G
G
V
V
I
Y
M
G
S
V
H
S
H
E
A
S
P
L
K
S
A
Y
V
T
A
K
H
G
L
L
G
L
A
R
V
L
A
K
E
G
A
K
H
N
V
R
S
H
V
V
C
P
G
F
V
R
T
P
L
V
---
D
K
Q
I
P
E
Q
-----
I
S
E
E
E
V
-
I
K
K
V
M
L
G
N
T
V
D
G
V
F
T
T
V
Q
D
V
A
Q
T
V
L
F
L
S
A
F
P
S
A
A
L
T
G
Q
S
F
I
V
S
H
G
-------
107
HHSearch
84.88
32%
-93
- C2 -
4TRR
2
?
A:
[9-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
N
L
N
G
K
T
A
V
V
T
G
A
A
S
G
I
G
K
E
I
A
L
E
L
A
K
A
G
A
A
V
A
I
A
D
L
N
Q
D
G
A
N
A
V
A
D
E
I
N
K
A
--
G
G
K
A
I
G
V
A
M
D
V
T
N
E
E
A
V
N
T
G
I
D
K
V
A
E
A
F
G
S
V
D
I
L
V
S
N
A
G
I
Q
I
V
N
P
I
E
N
Y
S
--
F
A
D
W
K
K
M
Q
A
I
H
V
D
G
A
F
L
-
T
T
K
A
A
L
K
H
M
Y
K
D
D
R
G
G
V
V
I
Y
M
G
S
V
H
S
H
E
A
S
P
L
K
S
A
Y
V
T
A
K
H
G
L
L
G
L
A
R
V
L
A
K
E
G
A
K
H
N
V
R
S
H
V
V
C
P
G
F
V
R
T
P
--
L
V
D
K
Q
I
P
E
Q
------
I
-
S
E
E
E
V
I
K
K
V
M
L
G
N
T
V
D
G
V
F
T
T
V
Q
D
V
A
Q
T
V
L
F
L
S
A
F
P
S
A
A
L
T
G
Q
S
F
I
V
S
H
G
W
F
M
----
5
PsiBlast_PDB
84.78
32%
-92
- C2 -
4TRR
2
?
A:
[10-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
L
N
G
K
T
A
V
V
T
G
A
A
S
G
I
G
K
E
I
A
L
E
L
A
K
A
G
A
A
V
A
I
A
D
L
N
Q
D
G
A
N
A
V
A
D
E
I
N
K
A
G
G
K
--
A
I
G
V
A
M
D
V
T
N
E
E
A
V
N
T
G
I
D
K
V
A
E
A
F
G
S
V
D
I
L
V
S
N
A
G
I
Q
I
V
N
P
I
E
N
Y
S
--
F
A
D
W
K
K
M
Q
A
I
H
V
D
G
A
F
L
-
T
T
K
A
A
L
K
H
M
Y
K
D
D
R
G
G
V
V
I
Y
M
G
S
V
H
S
H
E
A
S
P
L
K
S
A
Y
V
T
A
K
H
G
L
L
G
L
A
R
V
L
A
K
E
G
A
K
H
N
V
R
S
H
V
V
C
P
G
F
V
R
T
P
L
V
---
D
K
Q
I
P
E
Q
-----
I
S
E
E
E
V
-
I
K
K
V
M
L
G
N
T
V
D
G
V
F
T
T
V
Q
D
V
A
Q
T
V
L
F
L
S
A
F
P
S
A
A
L
T
G
Q
S
F
I
V
S
H
G
-------
29
PsiBlast_CBE
84.76
32%
-109
- C2 -
2D1Y
1
?
B:
[4-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
G
K
G
V
L
V
T
G
G
A
R
G
I
G
R
A
I
A
Q
A
F
A
R
E
G
A
L
V
A
L
C
D
L
R
P
E
G
-
K
E
V
A
E
A
I
G
G
A
F
-------
F
Q
V
D
L
E
D
E
R
E
R
V
R
F
V
E
E
A
A
Y
A
L
G
R
V
D
V
L
V
N
N
A
A
I
A
A
P
G
S
A
L
T
V
R
--
L
P
E
W
R
R
V
L
E
V
N
L
T
A
P
M
H
-
L
S
A
L
A
A
R
E
M
R
K
V
G
-
G
G
A
I
V
N
V
A
S
V
Q
G
L
F
A
E
Q
E
N
A
A
Y
N
A
S
K
G
G
L
V
N
L
T
R
S
L
A
L
D
L
A
P
L
R
I
R
V
N
A
V
A
P
G
A
I
A
T
E
A
V
L
--------
E
A
I
--------
R
-
T
R
R
D
W
E
D
L
H
A
L
R
R
L
G
K
P
E
E
V
A
E
A
V
L
F
L
A
S
E
K
A
S
F
I
T
G
A
I
L
P
V
D
G
G
M
T
A
S
F
--
22
PsiBlast_CBE
84.23
32%
-97
- C2 -
4TRR
1
?
H:
[11-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
N
G
K
T
A
V
V
T
G
A
A
S
G
I
G
K
E
I
A
L
E
L
A
K
A
G
A
A
V
A
I
A
D
L
N
Q
D
G
A
N
A
V
A
D
E
I
N
K
A
G
G
K
--
A
I
G
V
A
M
D
V
T
N
E
E
A
V
N
T
G
I
D
K
V
A
E
A
F
G
S
V
D
I
L
V
S
N
A
G
I
Q
I
V
N
P
I
E
N
Y
S
--
F
A
D
W
K
K
M
Q
A
I
H
V
D
G
A
F
L
-
T
T
K
A
A
L
K
H
M
Y
K
D
D
R
G
G
V
V
I
Y
M
G
S
V
H
S
H
E
A
S
P
L
K
S
A
Y
V
T
A
K
H
G
L
L
G
L
A
R
V
L
A
K
E
G
A
K
H
N
V
R
S
H
V
V
C
P
G
F
V
R
T
P
L
V
---
D
K
Q
I
P
E
Q
A
K
---
I
S
E
E
E
V
-
I
K
K
V
M
L
G
N
T
V
D
G
V
F
T
T
V
Q
D
V
A
Q
T
V
L
F
L
S
A
F
P
S
A
A
L
T
G
Q
S
F
I
V
S
H
G
-------
26
PsiBlast_CBE
84.18
32%
-92
- C2 -
4TRR
2
?
B:
[10-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
L
N
G
K
T
A
V
V
T
G
A
A
S
G
I
G
K
E
I
A
L
E
L
A
K
A
G
A
A
V
A
I
A
D
L
N
Q
D
G
A
N
A
V
A
D
E
I
N
K
A
G
G
K
--
A
I
G
V
A
M
D
V
T
N
E
E
A
V
N
T
G
I
D
K
V
A
E
A
F
G
S
V
D
I
L
V
S
N
A
G
I
Q
I
V
N
P
I
E
N
Y
S
--
F
A
D
W
K
K
M
Q
A
I
H
V
D
G
A
F
L
-
T
T
K
A
A
L
K
H
M
Y
K
D
D
R
G
G
V
V
I
Y
M
G
S
V
H
S
H
E
A
S
P
L
K
S
A
Y
V
T
A
K
H
G
L
L
G
L
A
R
V
L
A
K
E
G
A
K
H
N
V
R
S
H
V
V
C
P
G
F
V
R
T
P
L
V
---
D
K
Q
I
P
E
Q
A
K
E
L
G
I
S
E
E
E
V
-
I
K
K
V
M
L
G
N
T
V
D
G
V
F
T
T
V
Q
D
V
A
Q
T
V
L
F
L
S
A
F
P
S
A
A
L
T
G
Q
S
F
I
V
S
H
G
-------
17
PsiBlast_PDB
83.70
29%
-95
- C2 -
2PNF
3
FABG_AQUAE
A:
[2-247]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
K
L
Q
G
K
V
S
L
V
T
G
S
T
R
G
I
G
R
A
I
A
E
K
L
A
S
A
G
S
T
V
I
I
T
G
T
S
G
E
R
A
K
A
V
A
E
E
I
A
N
K
Y
G
V
-
K
A
H
G
V
E
M
N
L
L
S
E
E
S
I
N
K
A
F
E
E
I
Y
N
L
V
D
G
I
D
I
L
V
N
N
A
G
I
T
R
D
K
L
F
L
R
M
S
--
L
L
D
W
E
E
V
L
K
V
N
L
T
G
T
F
L
-
V
T
Q
N
S
L
R
K
M
I
K
Q
-
R
W
G
R
I
V
N
I
S
S
V
V
G
F
T
G
N
V
G
Q
V
N
Y
S
T
T
K
A
G
L
I
G
F
T
K
S
L
A
K
E
L
A
P
R
N
V
L
V
N
A
V
A
P
G
F
I
--------------
E
T
D
M
T
A
V
-
L
S
E
E
-
I
K
Q
K
Y
K
E
Q
I
P
L
G
R
F
G
S
P
E
E
V
A
N
V
V
L
F
L
C
S
E
L
A
S
Y
I
T
G
E
V
I
H
V
N
G
G
M
------
53
PsiBlast_CBE
83.64
32%
-106
- C2 -
3WYE
1
BUDC_CORGT (first)
B:
[3-253]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
A
L
V
T
G
A
G
Q
G
I
G
K
A
I
A
L
R
L
V
K
D
G
F
A
V
A
I
A
D
Y
N
D
A
T
A
K
A
V
A
S
E
I
N
Q
A
--
G
G
H
A
V
A
V
K
V
D
V
S
D
R
D
Q
V
F
A
A
V
E
Q
A
R
K
T
L
G
G
F
D
V
I
V
N
N
A
G
I
A
Q
I
K
P
L
L
E
V
T
--
E
E
D
L
K
Q
I
Y
S
V
N
V
F
S
V
F
F
-
G
I
Q
A
A
V
E
A
F
K
K
E
G
H
G
G
K
I
I
N
A
A
S
I
A
A
I
Q
G
F
P
I
L
S
A
Y
S
T
T
K
F
A
V
R
G
L
T
Q
T
A
A
R
D
L
A
P
L
G
I
T
V
N
G
Y
C
P
G
I
V
--
G
T
G
M
W
-
E
Q
I
D
A
E
L
S
K
-----------------
S
I
A
L
G
R
P
S
V
P
E
D
V
A
G
L
V
S
F
L
A
S
P
D
S
D
Y
M
T
G
Q
S
L
L
I
D
G
G
M
------
23
PsiBlast_CBE
83.55
32%
-94
- C2 -
4TRR
1
?
F:
[10-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
L
N
G
K
T
A
V
V
T
G
A
A
S
G
I
G
K
E
I
A
L
E
L
A
K
A
G
A
A
V
A
I
A
D
L
N
Q
D
G
A
N
A
V
A
D
E
I
N
K
A
G
G
K
--
A
I
G
V
A
M
D
V
T
N
E
E
A
V
N
T
G
I
D
K
V
A
E
A
F
G
S
V
D
I
L
V
S
N
A
G
I
Q
I
V
N
P
I
E
N
Y
S
--
F
A
D
W
K
K
M
Q
A
I
H
V
D
G
A
F
L
-
T
T
K
A
A
L
K
H
M
Y
K
D
D
R
G
G
V
V
I
Y
M
G
S
V
H
S
H
E
A
S
P
L
K
S
A
Y
V
T
A
K
H
G
L
L
G
L
A
R
V
L
A
K
E
G
A
K
H
N
V
R
S
H
V
V
C
P
G
F
V
R
T
P
L
V
---
D
K
Q
I
P
E
------
I
S
E
E
E
V
-
I
K
K
V
M
L
G
N
T
V
D
G
V
F
T
T
V
Q
D
V
A
Q
T
V
L
F
L
S
A
F
P
S
A
A
L
T
G
Q
S
F
I
V
S
H
G
-------
18
PsiBlast_PDB
83.49
29%
-95
- C2 -
2P68
-
FABG_AQUAE
A:
[2-247]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
K
L
Q
G
K
V
S
L
V
T
G
S
T
R
G
I
G
R
A
I
A
E
K
L
A
S
A
G
S
T
V
I
I
T
G
T
S
G
E
R
A
K
A
V
A
E
E
I
A
N
K
Y
G
V
-
K
A
H
G
V
E
M
N
L
L
S
E
E
S
I
N
K
A
F
E
E
I
Y
N
L
V
D
G
I
D
I
L
V
N
N
A
G
I
T
R
D
K
L
F
L
R
M
S
--
L
L
D
W
E
E
V
L
K
V
N
L
T
G
T
F
L
-
V
T
Q
N
S
L
R
K
M
I
K
Q
-
R
W
G
R
I
V
N
I
S
S
V
V
G
F
T
G
N
V
G
Q
V
N
Y
S
T
T
K
A
G
L
I
G
F
T
K
S
L
A
K
E
L
A
P
R
N
V
L
V
N
A
V
A
P
G
F
I
--------------
E
T
D
M
T
A
V
-
L
S
E
E
-
I
K
Q
K
Y
K
E
Q
I
P
L
G
R
F
G
S
P
E
E
V
A
N
V
V
L
F
L
C
S
E
L
A
S
Y
I
T
G
E
V
I
H
V
N
G
G
M
------