@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu31360: (2016-07-22 )
MENFTYYNPTKLIFGKGQLEQLRKEFKRYGKNVLLVYGGGSIKRNGLYDQVTGILKEEGAVVHELSGVEPNPRLATVEKGIGLCREHDIDFLLAVGGGSVIDCTKAIAAGVKYDGDAWDIFSKKVTAEDALPFGTVLTLAATGSEMNPDSVITNWETNEKFVWGSNVTHPRFSILDPENTFTVPENQTVYGMVDMMSHVFEQYFHNVENTPLQDRMCFAVLQTVIETAPKLLEDLENYELRETILYAGTIALNGTLQMGYFGDWASHTMEHAVSAVYDIPHAGGLAILFPNWMRYTLDTNVGRFKNLMLNMFDIDTEGKTDKEIALEGIDKLSAFWTSLGAPSRLADYNIGEEKLELIADIAAKEMEHGGFGNFQKLNKDDVLAILRASL
Atome Classification :
(20 SA)
---.........10........20........30..-.......40...-......50........60........70........80........90........100.......110.--..-....---120-.---..---..-...130.......140.......150.......160.......170.......180.......190.......200.......210------.......220.......230-----......-...240.....---.-.250-..---......-260--------........270...---....280.......290.......300.......310........320.......330.......340.......350.......360--.....---...------.370.........380.......390
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MENFTYYNP
T
K
L
I
FGK
G
Q
L
E
Q
L
R
K
E
F
K
RYG-K
N
-
V
L
L
V
YGGG-SIK-RNG
L
Y
D
Q
V
T
G
I
L
KEEG
A
V
V
H
ELSGVEPNP
R
L
A
T
V
E
K
G
IG
L
C
R
EHDI
D
F
L
L
A
VGGGSV
I
D
C
T
K
A
I
AAGVKY--DG-
D
A
W
D
---
I
F
--S---KK---VT-AEDALPF
G
T
V
L
T
L
AATGSEMNPD
S
V
ITNWETNE
K
F
V
WGSNVTHP
R
F
S
I
LDPEN
T
F
TVPENQ
T
V
Y
G
M
V
D
M
M
S
H
V
F
E
Q
Y
F
H
NVENTP
L
------
Q
D
R
M
C
F
A
V
L
Q
T
V
I
E
T
A
P
K
-------
L
L
E
D
L
E
-
N
Y
E
L
R
E
T
I
L
Y
A
---
G
-
T
I
A
--LN---
G
T
L
Q
MG-YF---------G
D
W
A
S
H
T
M
E
H
A
V
S
A
---
V
YDIPHAG
G
L
A
I
LFPN
W
M
R
Y
T
LDT
N
V
G
R
F
K
N
L
M
L
N
M
-
F
DIDTEGKT
D
K
E
I
A
L
E
G
I
D
K
L
S
A
F
W
T
SLGAPSRLADYNI
G
E
E
K
L
E
L
I
A
D
----
I
A
A
K
E
---
M
EH------GG--FGNFQKL
N
K
D
D
V
L
A
I
L
R
ASL
40
HHSearch
83.81
41%
-20
- C3 -
1VLJ
2
?
A:
[13-406]
---
M
E
N
F
V
F
H
N
P
T
K
I
V
F
G
R
G
T
I
P
K
I
G
E
E
I
K
N
A
G
-
I
R
K
V
L
F
L
Y
G
G
G
-
S
I
K
-
K
N
G
V
Y
D
Q
V
V
D
S
L
K
K
H
G
I
E
W
V
E
V
S
G
V
K
P
N
P
V
L
S
K
V
H
E
A
V
E
V
A
K
K
E
K
V
E
A
V
L
G
V
G
G
G
S
V
V
D
S
A
K
A
V
A
A
G
A
L
Y
--
E
G
-
D
I
W
D
---
A
F
--
I
---
G
K
---
Y
Q
-
I
E
K
A
L
P
I
F
D
V
L
T
I
S
A
T
G
T
E
M
N
G
N
A
V
I
T
N
E
K
T
K
E
K
Y
G
V
S
S
K
A
L
Y
P
K
V
S
I
I
D
P
S
V
Q
F
T
L
P
K
E
Q
T
V
Y
G
A
V
D
A
I
S
H
I
L
E
Y
Y
F
D
G
S
S
P
-
E
I
------
S
N
E
I
A
E
G
T
I
R
T
I
M
K
M
T
E
R
-------
L
I
E
K
P
D
-
D
Y
E
A
R
A
N
L
A
W
S
---
A
-
T
I
A
--
L
N
GTM
A
V
G
R
R
---
G
---------
G
E
W
A
C
H
R
I
E
H
S
L
S
A
---
L
Y
D
I
A
H
G
A
G
L
A
I
V
F
P
A
W
M
K
Y
V
Y
R
K
N
P
A
Q
F
E
R
F
A
K
K
I
-
F
G
F
E
G
E
---
G
E
E
L
I
L
K
G
I
E
A
F
K
N
W
L
K
K
V
G
A
P
V
S
L
K
D
A
G
I
P
E
E
D
I
D
K
I
V
D
----
N
V
M
L
L
---
V
E
K
NLKPKG
A
S
--
L
G
R
I
M
V
L
E
R
E
D
V
R
E
I
L
K
L
A
A
21
PsiBlast_CBE
83.71
41%
-9
- C3 -
1VLJ
2
?
B:
[13-403]
---
M
E
N
F
V
F
H
N
P
T
K
I
V
F
G
R
G
T
I
P
K
I
G
E
E
I
K
N
A
G
I
R
K
-
V
L
F
L
Y
G
G
G
-
S
I
K
-
K
N
G
V
Y
D
Q
V
V
D
S
L
K
K
H
G
I
E
W
V
E
V
S
G
V
K
P
N
P
V
L
S
K
V
H
E
A
V
E
V
A
K
K
E
K
V
E
A
V
L
G
V
G
G
G
S
V
V
D
S
A
K
A
V
A
A
G
A
L
Y
--
E
G
-
D
I
W
D
---
A
F
--
I
---
G
K
---
Y
Q
-
I
E
K
A
L
P
I
F
D
V
L
T
I
S
A
T
G
T
E
M
N
G
N
A
V
I
T
N
E
K
T
K
E
K
Y
G
V
S
S
K
A
L
Y
P
K
V
S
I
I
D
P
S
V
Q
F
T
L
P
K
E
Q
T
V
Y
G
A
V
D
A
I
S
H
I
L
E
Y
Y
F
D
G
-
S
S
P
E
I
------
S
N
E
I
A
E
G
T
I
R
T
I
M
K
M
T
E
R
-------
L
I
E
K
P
D
-
D
Y
E
A
R
A
N
L
A
W
S
---
A
-
T
I
A
--
L
N
---
G
T
M
A
V
G
-
R
R
G--------
G
E
W
A
C
H
R
I
E
H
S
L
S
A
---
L
Y
D
I
A
H
G
A
G
L
A
I
V
F
P
A
W
M
K
Y
V
Y
R
K
N
P
A
Q
F
E
R
F
A
K
K
I
-
F
G
F
E
G
E
G
---
E
E
L
I
L
K
G
I
E
A
F
K
N
W
L
K
K
V
G
A
P
V
S
L
K
D
A
G
I
P
E
E
D
I
D
K
I
V
D
N
V
M
L
L
V
E
K
N
---
L
K
P
------
K
G
AS
L
G
R
I
M
V
L
E
R
E
D
V
R
E
I
L
K
---
1
PsiBlast_PDB
83.42
41%
-11
- C3 -
1VLJ
2
?
A:
[13-403]
---
M
E
N
F
V
F
H
N
P
T
K
I
V
F
G
R
G
T
I
P
K
I
G
E
E
I
K
N
A
G
I
R
K
-
V
L
F
L
Y
G
G
G
-
S
I
K
-
K
N
G
V
Y
D
Q
V
V
D
S
L
K
K
H
G
I
E
W
V
E
V
S
G
V
K
P
N
P
V
L
S
K
V
H
E
A
V
E
V
A
K
K
E
K
V
E
A
V
L
G
V
G
G
G
S
V
V
D
S
A
K
A
V
A
A
G
A
L
Y
--
E
G
-
D
I
W
D
---
A
F
--
I
---
G
K
---
Y
Q
-
I
E
K
A
L
P
I
F
D
V
L
T
I
S
A
T
G
T
E
M
N
G
N
A
V
I
T
N
E
K
T
K
E
K
Y
G
V
S
S
K
A
L
Y
P
K
V
S
I
I
D
P
S
V
Q
F
T
L
P
K
E
Q
T
V
Y
G
A
V
D
A
I
S
H
I
L
E
Y
Y
F
D
G
-
S
S
P
E
I
------
S
N
E
I
A
E
G
T
I
R
T
I
M
K
M
T
E
R
-------
L
I
E
K
P
D
-
D
Y
E
A
R
A
N
L
A
W
S
---
A
-
T
I
A
--
L
N
---
G
T
M
A
V
G
-
R
R
G--------
G
E
W
A
C
H
R
I
E
H
S
L
S
A
---
L
Y
D
I
A
H
G
A
G
L
A
I
V
F
P
A
W
M
K
Y
V
Y
R
K
N
P
A
Q
F
E
R
F
A
K
K
I
-
F
G
F
E
G
E
G
---
E
E
L
I
L
K
G
I
E
A
F
K
N
W
L
K
K
V
G
A
P
V
S
L
K
D
A
G
I
P
E
E
D
I
D
K
I
V
D
N
V
M
L
L
V
E
K
N
---
L
K
P
------
K
G
AS
L
G
R
I
M
V
L
E
R
E
D
V
R
E
I
L
K
---
23
PsiBlast_CBE
82.53
38%
-45
- C3 -
1OJ7
3
YQHD_ECOLI
C:
[22-385]
---
L
N
N
F
N
L
H
T
P
T
R
I
L
F
G
K
G
A
I
A
G
L
R
E
Q
I
P
-
H
D
-
A
R
-
V
L
I
T
Y
G
G
G
-
S
V
K
-
K
T
G
V
L
D
Q
V
L
D
A
L
K
--
G
M
D
V
L
E
F
G
G
I
E
P
N
P
A
Y
E
T
L
M
N
A
V
K
L
V
R
E
Q
K
V
T
F
L
L
A
V
G
G
G
S
V
L
D
G
T
K
F
I
A
A
A
A
N
Y
PE
N
I
-
D
P
W
H
---
I
L
--
Q
TGG
K
E
---
I
---
K
S
A
I
P
M
G
C
V
L
T
L
P
A
T
G
S
E
S
N
A
G
A
V
I
S
R
K
T
T
G
D
K
Q
A
F
H
S
A
H
V
Q
P
V
F
A
V
L
D
P
V
Y
T
Y
T
L
P
P
R
Q
V
A
N
G
V
V
D
A
F
V
H
T
V
E
Q
Y
V
T
K
P
V
D
A
K
I
------
H
D
R
F
A
E
G
I
L
L
T
L
I
E
D
G
P
K
-------
A
L
K
E
P
E
-
N
Y
D
V
R
A
N
V
M
W
A
---
A
-
T
Q
A
--
L
N
---
G
L
I
G
A
G
-
V
P
---------
Q
D
W
A
T
H
M
L
G
H
E
L
T
A
---
M
H
G
L
D
H
A
Q
T
L
A
I
V
L
P
A
L
W
N
E
K
R
D
T
K
R
A
K
L
L
Q
Y
A
E
R
V
-
W
N
I
-
T
E
G
S
D
D
E
R
I
D
-
A
A
I
A
A
T
R
N
F
F
E
Q
L
G
V
P
T
H
L
S
D
Y
G
L
D
G
S
S
---
I
P
A
----
L
L
K
K
L
---
E
E
H
------
G
-----------------------
2
PsiBlast_PDB
81.51
38%
-38
- C3 -
1OJ7
2
YQHD_ECOLI
A:
[22-385]
---
L
N
N
F
N
L
H
T
P
T
R
I
L
F
G
K
G
A
I
A
G
L
R
E
Q
I
P
-
H
D
-
A
R
-
V
L
I
T
Y
G
G
G
-
S
V
K
-
K
T
G
V
L
D
Q
V
L
D
A
L
K
--
G
M
D
V
L
E
F
G
G
I
E
P
N
P
A
Y
E
T
L
M
N
A
V
K
L
V
R
E
Q
K
V
T
F
L
L
A
V
G
G
G
S
V
L
D
G
T
K
F
I
A
A
A
A
N
Y
PE
N
I
-
D
P
W
H
---
I
L
--
Q
T
GG
K
E
---
I
---
K
S
A
I
P
M
G
C
V
L
T
L
P
A
T
G
S
E
S
N
A
G
A
V
I
S
R
K
T
T
G
D
K
Q
A
F
H
S
A
H
V
Q
P
V
F
A
V
L
D
P
V
Y
T
Y
T
L
P
P
R
Q
V
A
N
G
V
V
D
A
F
V
H
T
V
E
Q
Y
V
T
K
P
V
D
A
K
I
------
H
D
R
F
A
E
G
I
L
L
T
L
I
E
D
G
P
K
-------
A
L
K
E
P
E
-
N
Y
D
V
R
A
N
V
M
W
A
---
A
-
T
Q
A
--
L
N
---
G
L
I
G
A
G
-
V
P
---------
Q
D
W
A
T
H
M
L
G
H
E
L
T
A
---
M
H
G
L
D
H
A
Q
T
L
A
I
V
L
P
A
L
W
N
E
K
R
D
T
K
R
A
K
L
L
Q
Y
A
E
R
V
-
W
N
I
-
T
E
G
S
D
D
E
R
I
D
-
A
A
I
A
A
T
R
N
F
F
E
Q
L
G
V
P
T
H
L
S
D
Y
G
L
D
G
S
S
---
I
P
A
----
L
L
K
K
L
---
E
E
H
------
G
-----------------------
22
PsiBlast_CBE
81.46
38%
-39
- C3 -
1OJ7
2
YQHD_ECOLI
D:
[22-385]
---
L
N
N
F
N
L
H
T
P
T
R
I
L
F
G
K
G
A
I
A
G
L
R
E
Q
I
P
-
H
D
-
A
R
-
V
L
I
T
Y
G
G
G
-
S
V
K
-
K
T
G
V
L
D
Q
V
L
D
A
L
K
--
G
M
D
V
L
E
F
G
G
I
E
P
N
P
A
Y
E
T
L
M
N
A
V
K
L
V
R
E
Q
K
V
T
F
L
L
A
V
G
G
G
S
V
L
D
G
T
K
F
I
A
A
A
A
N
Y
PE
N
I
-
D
P
W
H
---
I
L
--
Q
TGG
K
E
---
I
---
K
S
A
I
P
M
G
C
V
L
T
L
P
A
T
G
S
E
S
N
A
G
A
V
I
S
R
K
T
T
G
D
K
Q
A
F
H
S
A
H
V
Q
P
V
F
A
V
L
D
P
V
Y
T
Y
T
L
P
P
R
Q
V
A
N
G
V
V
D
A
F
V
H
T
V
E
Q
Y
V
T
K
P
V
D
A
K
I
------
H
D
R
F
A
E
G
I
L
L
T
L
I
E
D
G
P
K
-------
A
L
K
E
P
E
-
N
Y
D
V
R
A
N
V
M
W
A
---
A
-
T
Q
A
--
L
N
---
G
L
I
G
A
G
-
V
P
---------
Q
D
W
A
T
H
M
L
G
H
E
L
T
A
---
M
H
G
L
D
H
A
Q
T
L
A
I
V
L
P
A
L
W
N
E
K
R
D
T
K
R
A
K
L
L
Q
Y
A
E
R
V
-
W
N
I
-
T
E
G
S
D
D
E
R
I
D
-
A
A
I
A
A
T
R
N
F
F
E
Q
L
G
V
P
T
H
L
S
D
Y
G
L
D
G
S
S
---
I
P
A
----
L
L
K
K
L
---
E
E
H
------
G
-----------------------
24
PsiBlast_CBE
80.70
38%
-36
- C3 -
1OJ7
2
YQHD_ECOLI
B:
[22-385]
---
L
N
N
F
N
L
H
T
P
T
R
I
L
F
G
K
G
A
I
A
G
L
R
E
Q
I
P
-
H
D
-
A
R
-
V
L
I
T
Y
G
G
G
-
S
V
K
-
K
T
G
V
L
D
Q
V
L
D
A
L
K
--
G
M
D
V
L
E
F
G
G
I
E
P
N
P
A
Y
E
T
L
M
N
A
V
K
L
V
R
E
Q
K
V
T
F
L
L
A
V
G
G
G
S
V
L
D
G
T
K
F
I
A
A
A
A
N
Y
PE
N
I
-
D
P
W
H
---
I
L
--
Q
TGG
K
E
---
I
---
K
S
A
I
P
M
G
C
V
L
T
L
P
A
T
G
S
E
S
N
A
G
A
V
I
S
R
K
T
T
G
D
K
Q
A
F
H
S
A
H
V
Q
P
V
F
A
V
L
D
P
V
Y
T
Y
T
L
P
P
R
Q
V
A
N
G
V
V
D
A
F
V
H
T
V
E
Q
Y
V
T
K
P
V
D
A
K
I
------
H
D
R
F
A
E
G
I
L
L
T
L
I
E
D
G
P
K
-------
A
L
K
E
P
E
-
N
Y
D
V
R
A
N
V
M
W
A
---
A
-
T
Q
A
--
L
N
---
G
L
I
G
A
G
-
V
P
---------
Q
D
W
A
T
H
M
L
G
H
E
L
T
A
---
M
H
G
L
D
H
A
Q
T
L
A
I
V
L
P
A
L
W
N
E
K
R
D
T
K
R
A
K
L
L
Q
Y
A
E
R
V
-
W
N
I
-
T
E
G
S
D
D
E
R
I
D
-
A
A
I
A
A
T
R
N
F
F
E
Q
L
G
V
P
T
H
L
S
D
Y
G
L
D
G
S
S
---
I
P
A
----
L
L
K
K
L
---
E
E
H
------
G
-----------------------
3
PsiBlast_PDB
77.98
28%
-88
- C3 -
3OWO
1
ADH2_ZYMMO
A:
[2-360]
----
A
S
S
T
F
Y
I
P
F
V
N
E
M
G
E
G
S
L
E
K
A
I
K
D
L
N
G
S
G
-
F
K
-
N
A
L
I
V
S
D
A
-
F
M
N
-
K
S
G
V
V
K
Q
V
A
D
L
L
K
A
Q
G
I
N
S
A
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
A
L
V
A
T
N
--
G
G
-
E
V
K
D
---
Y
E
--
G
---
I
D
---
K
S
-
K
K
P
A
L
P
L
M
S
I
N
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
-
S
S
T
A
A
T
P
I
------
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
T
-------
A
C
D
N
G
K
-
D
M
P
A
R
E
A
M
A
Y
A
Q
F
L
A
-
G
M
A
--
F
N
---
N
A
-
S
L
G
-
Y
V
--------------
H
A
M
A
H
Q
L
G
G
---
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
S
V
V
A
G
R
L
K
D
V
G
V
A
M
G
L
D
I
A
N
L
G
--
D
K
E
G
A
E
A
T
I
Q
A
V
R
D
L
A
A
S
I
G
I
P
A
N
L
T
E
L
G
A
K
K
E
D
V
P
L
L
A
D
----
H
A
L
K
D
------------------------------------
4
PsiBlast_PDB
77.31
28%
-83
- C3 -
3OX4
2
ADH2_ZYMMO
A:
[2-360]
----
A
S
S
T
F
Y
I
P
F
V
N
E
M
G
E
G
S
L
E
K
A
I
K
D
L
N
G
S
G
-
F
K
-
N
A
L
I
V
S
D
A
-
F
M
N
-
K
S
G
V
V
K
Q
V
A
D
L
L
K
A
Q
G
I
N
S
A
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
A
L
V
A
T
N
--
G
G
-
E
V
K
D
---
Y
E
--
G
---
I
D
---
K
S
-
K
K
P
A
L
P
L
M
S
I
N
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
-
S
S
T
A
A
T
P
I
------
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
T
-------
A
C
D
N
G
K
-
D
M
P
A
R
E
A
M
A
Y
A
Q
F
L
A
-
G
M
A
--
F
N
---
N
A
-
S
L
G
-
Y
V
--------------
H
A
M
A
H
Q
L
G
G
---
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
S
V
V
A
G
R
L
K
D
V
G
V
A
M
G
L
D
I
A
N
L
G
--
D
K
E
G
A
E
A
T
I
Q
A
V
R
D
L
A
A
S
I
G
I
P
A
N
L
T
E
L
G
A
K
K
E
D
V
P
L
L
A
D
----
H
A
L
K
D
------------------------------------
38
HHSearch
72.30
28%
-18
- C3 -
3BFJ
1
DHAT_KLEPN
A:
[4-387]
----
R
M
F
D
Y
L
V
P
N
V
N
F
F
G
P
N
A
I
S
V
V
G
E
R
C
Q
L
L
G
-
G
K
K
A
L
L
V
T
D
K
G
-
L
R
--
K
D
G
A
V
D
K
T
L
H
Y
L
R
E
A
G
I
E
V
A
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
A
T
H
--
E
G
-
D
L
Y
Q
---
Y
A
--
G
---
I
E
---
T
L
-
T
N
P
L
P
P
I
V
A
V
N
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
-
P
V
------
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
-------
A
V
A
L
G
S
-
N
L
Q
A
R
E
Y
M
A
Y
A
---
S
-
L
L
A
--
G
M
---
A
F
N
N
A
N
L
G
-------------
Y
V
H
A
M
A
H
Q
L
G
G
---
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
I
A
N
P
E
K
F
A
D
I
A
E
L
--
M
G
E
N
I
T
G
L
S
T
L
D
A
A
E
K
A
I
A
A
I
T
R
L
S
M
D
I
G
I
P
Q
H
L
R
D
L
G
V
K
E
T
D
F
P
Y
M
A
E
----
M
A
L
K
D
---
G
N
--------
A
--
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
A
F
5
PsiBlast_PDB
72.25
28%
-15
- C3 -
3BFJ
1
DHAT_KLEPN
A:
[6-387]
------
F
D
Y
L
V
P
N
V
N
F
F
G
P
N
A
I
S
V
V
G
E
R
C
Q
L
L
G
G
K
K
-
A
L
L
V
T
D
K
G
L
R
---
K
D
G
A
V
D
K
T
L
H
Y
L
R
E
A
G
I
E
V
A
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
A
T
H
--
E
G
-
D
L
Y
Q
---
Y
A
--
G
---
I
E
---
T
L
-
T
N
P
L
P
P
I
V
A
V
N
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
-
P
V
------
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
-------
A
V
A
L
G
S
-
N
L
Q
A
R
E
Y
M
A
Y
A
---
S
-
L
L
A
G
M
A
F
---
N
N
A
N
L
G
-
Y
V
--------------
H
A
M
A
H
Q
L
G
G
---
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
I
A
N
P
E
K
F
A
D
I
A
E
L
M
-
G
E
-
N
I
T
G
L
S
T
L
D
A
A
E
K
A
I
A
A
I
T
R
L
S
M
D
I
G
I
P
Q
H
L
R
D
L
G
V
K
E
T
D
F
P
Y
M
A
E
----
M
A
L
K
-----
D
G
------
N
A
--
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
A
F
25
Fugue
71.81
34%
25
- C3 -
1OJ7
2
YQHD_ECOLI
A:
[19-408]
KAG
L
N
N
F
N
L
H
T
P
T
R
I
L
F
G
K
G
A
I
A
G
L
R
E
Q
I
P
H
D
A
-
R
V
-
L
I
T
Y
-
G
G
G
-
S
V
K
-
K
T
G
V
L
D
Q
V
L
D
A
L
K
--
G
M
D
V
L
E
F
G
G
I
E
P
N
P
A
Y
E
T
L
M
N
A
V
K
L
V
R
E
Q
K
V
T
F
L
L
A
V
G
G
G
S
V
L
D
G
T
K
F
I
A
A
A
A
N
Y
--
P
E
-
N
I
D
P
W
H
I
L
Q
--
T
---
G
G
---
K
E
-
I
K
S
A
I
P
M
G
C
V
L
T
L
P
A
T
G
S
E
S
N
A
G
A
V
I
S
R
K
T
T
G
D
K
Q
A
F
H
S
A
H
V
Q
P
V
F
A
V
L
D
P
V
Y
T
Y
T
L
P
P
R
Q
V
A
N
G
V
V
D
A
F
V
H
T
V
E
Q
Y
V
T
K
P
V
D
A
K
I
------
H
D
R
F
A
E
G
I
L
L
T
L
I
E
D
G
P
K
-------
A
L
K
E
P
E
-
N
Y
D
V
R
A
N
V
M
W
A
---
A
-
T
Q
A
--
L
N
---
G
L
I
G
A
G
-
V
P
---------
Q
D
W
A
T
H
M
L
G
H
E
L
T
A
---
M
H
G
L
D
H
A
Q
T
L
A
I
V
L
P
A
L
W
N
E
K
R
D
T
K
R
A
K
L
L
Q
Y
A
E
R
V
-
W
N
--
I
T
E
G
S
D
D
E
R
I
D
A
A
I
A
A
T
R
N
F
F
E
Q
L
G
V
P
T
H
L
S
D
Y
G
L
D
G
S
S
I
P
A
L
L
K
----
K
L
E
E
H
----
G
M
------
T
Q
--
L
G
E
N
H
D
I
T
L
D
V
S
R
R
I
Y
E
A
A
R
36
HHSearch
70.34
26%
-17
* C3 *
3OX4
2
ADH2_ZYMMO
A:
[2-383]
----
A
S
S
T
F
Y
I
P
F
V
N
E
M
G
E
G
S
L
E
K
A
I
K
D
L
N
G
S
G
-
F
K
N
A
L
I
V
S
D
A
F
--
M
N
-
K
S
G
V
V
K
Q
V
A
D
L
L
K
A
Q
G
I
N
S
A
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
A
L
V
A
T
N
--
G
G
-
E
V
K
D
---
Y
E
--
G
---
I
D
---
K
S
-
K
K
P
A
L
P
L
M
S
I
N
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
T
-
P
I
------
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
T
-------
A
C
D
N
G
K
-
D
M
P
A
R
E
A
M
A
Y
A
---
Q
-
F
L
A
--
G
M
---
A
F
N
N
A
S
L
G
-------------
Y
V
H
A
M
A
H
Q
L
G
G
---
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
S
V
V
A
G
R
L
K
D
V
G
V
A
--
M
G
L
D
I
A
N
L
G
D
K
E
G
A
E
A
T
I
Q
A
V
R
D
L
A
A
S
I
G
I
P
A
N
L
T
E
L
G
A
K
K
E
D
V
P
L
L
A
D
----
H
A
L
K
D
---
A
C
--------
A
--
L
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
L
S
A
F
35
HHSearch
68.10
24%
-23
- C3 -
5BR4
6
FUCO_ECOLI
A:
[1-383]
---
M
M
A
N
R
M
I
L
N
E
T
A
W
F
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
-
Y
Q
K
A
L
I
V
T
D
K
T
-
L
V
--
Q
C
G
V
V
A
K
V
T
D
K
M
D
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
--
P
E
-
F
-
A
D
---
V
R
SL
E
---
G
L
---
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
C
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
-
A
L
------
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
-------
S
V
A
G
---
D
K
D
A
G
E
E
M
A
L
G
---
Q
-
Y
V
A
--
G
M
---
G
F
S
N
V
G
L
G
-------------
L
V
H
G
M
A
H
P
L
G
A
---
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
R
V
--
M
G
V
K
V
E
G
M
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
L
A
Q
----
A
A
L
D
D
---
V
C
--------
T
--
G
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
W
13
PsiBlast_PDB
68.07
24%
-44
- C3 -
1RRM
4
FUCO_ECOLI
A:
[14-376]
----------------
F
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
-
Y
Q
-
K
A
L
I
V
T
D
K
-
T
L
V
-
Q
C
G
V
V
A
K
V
T
D
K
M
D
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
-
I
S
N
--
N
P
-
E
F
A
D
---
V
R
--
S
---
L
E
GLS
P
T
-
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
-
G
A
W
A
L
------
T
D
A
L
H
I
K
A
I
E
I
I
---
A
G
A
-------
L
R
G
S
V
A
G
D
K
D
A
G
E
E
M
A
L
G
---
Q
-
Y
V
A
--
G
M
---
G
F
S
N
V
G
-
L
------------
G
L
V
H
G
M
A
H
P
L
G
A
---
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
-
R
V
-
M
G
V
K
V
E
G
M
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
L
A
Q
----
A
A
L
D
D
---
V
C
T
------
G
----
G
N
P
R
E
A
T
L
E
D
I
V
-------
50
HHSearch
65.39
21%
-81
- C3 -
4MCA
5
?
A:
[2-355]
-----
L
R
I
I
Q
S
P
G
K
Y
I
Q
G
A
N
A
L
A
A
V
G
Q
Y
A
K
S
L
A
-
D
H
-
Y
L
V
I
A
D
D
F
-
V
M
K
-
L
A
--
G
D
T
L
M
G
S
L
Q
Q
H
G
V
K
H
H
-
A
A
L
F
N
G
E
C
C
H
K
E
I
D
R
L
G
R
E
L
K
A
H
G
C
R
G
V
I
G
V
G
G
G
K
T
L
D
T
A
K
A
I
A
H
Y
---------------------------------
Q
Q
L
P
V
V
L
I
P
T
I
A
S
T
D
A
P
T
S
A
L
S
V
I
Y
T
E
Q
G
-
E
F
A
E
Y
L
I
Y
P
R
N
P
D
M
V
V
M
D
V
A
I
I
A
K
A
P
V
R
L
L
V
A
G
M
G
D
A
L
S
T
Y
F
E
A
Q
A
C
F
D
A
Q
-
A
T
SMAGGK
S
T
L
A
A
L
S
L
A
R
L
C
Y
D
T
L
L
A
E
G
V
K
A
K
L
A
V
E
A
G
V
-
V
T
E
A
V
E
R
I
I
E
A
---
N
T
Y
L
S
--
G
I
---
G
F
E
S
S
G
L
A
-------------
A
A
H
A
I
H
N
G
F
T
V
LEE
C
H
H
L
Y
H
G
E
K
V
A
F
G
T
L
A
Q
--------------
L
V
L
---
Q
N
S
----------
P
M
A
Q
I
E
T
V
L
A
F
C
H
R
I
G
L
P
I
T
L
A
E
M
G
V
S
G
D
A
V
E
K
I
M
A
----
V
A
Q
A
S
C
AA
G
E
-------
T
I
--
H
N
M
P
F
K
V
T
P
A
G
V
Q
A
A
I
L
T
A
-
37
HHSearch
64.85
26%
3
- C3 -
4FR2
1
?
A:
[16-398]
-----
A
Y
D
F
L
M
P
S
V
N
F
F
G
P
G
V
I
S
K
I
G
E
R
A
K
M
L
G
-
M
K
K
P
V
I
V
T
D
K
F
-
L
E
N
L
K
N
G
A
V
A
Q
T
L
A
S
L
K
K
S
G
V
D
Y
V
V
Y
N
G
V
E
P
N
P
K
I
H
N
I
K
E
V
K
T
L
Y
E
K
E
D
A
D
S
I
I
T
V
G
G
G
S
A
H
D
T
G
K
G
A
G
I
I
M
T
N
--
G
D
-
D
I
T
K
---
L
A
--
G
---
I
E
---
T
L
-
K
N
P
L
P
P
L
I
A
V
N
T
T
A
G
T
G
S
E
L
T
R
H
A
V
I
T
N
E
E
T
H
L
K
F
V
V
V
S
W
R
N
I
P
L
V
S
F
N
D
P
T
L
M
L
D
I
P
K
G
L
T
A
A
T
G
M
D
A
F
V
Q
A
V
E
P
Y
V
S
V
D
H
N
-
P
I
------
T
D
S
Q
C
I
Q
A
I
K
L
I
E
S
S
L
R
E
-------
A
V
A
N
G
H
-
N
L
Q
A
R
T
K
M
V
E
A
---
E
-
M
L
A
--
G
M
---
A
F
N
N
A
N
L
G
-------------
Y
V
H
A
M
A
H
Q
L
G
G
---
Q
Y
D
A
P
H
G
V
C
C
A
L
L
L
P
Y
A
E
E
Y
N
L
I
A
D
P
E
R
F
A
E
L
A
R
I
--
M
G
E
N
T
D
G
L
S
T
R
D
A
A
E
L
S
I
K
A
M
K
Q
L
S
E
D
V
G
I
P
H
S
I
K
D
I
G
A
K
P
E
D
F
D
L
M
A
E
----
N
A
L
K
D
---
G
N
--------
A
--
F
S
N
P
R
K
G
T
K
E
D
I
V
K
I
F
Q
E
A
Y
11
PsiBlast_PDB
64.29
24%
-29
- C3 -
2BI4
3
FUCO_ECOLI
A:
[11-385]
---
M
A
N
R
M
I
L
N
E
T
A
W
-
F
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
-
Y
Q
-
K
A
L
I
V
T
D
K
-
T
L
V
-
Q
C
G
V
V
A
K
V
T
D
K
M
D
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
-
I
S
N
--
N
P
-
E
F
A
D
---
V
R
--
S
---
L
E
GLS
P
T
-
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
---------------
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
-------
I
I
A
G
-----
A
L
R
G
S
V
--
A
---
G
-
D
K
D
--
A
G
---
E
E
M
A
L
G
-
Q
Y
V
A
G
M
G
FSNV
G
L
G
L
V
H
G
M
A
H
P
L
G
A
---
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
-
R
V
-
M
G
V
K
V
E
G
M
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
L
A
Q
----
A
A
L
D
D
---
V
C
T
------
G
----
G
N
P
R
E
A
T
L
E
D
I
V
-------
42
HHSearch
63.58
26%
-38
- C3 -
1O2D
3
?
A:
[15-369]
-------
E
F
Y
M
P
T
D
V
F
F
G
E
K
I
L
E
K
R
G
N
I
I
D
L
L
G
-
K
R
-
A
L
V
V
T
G
K
S
-
S
S
K
-
K
N
G
S
L
D
D
L
K
K
L
L
D
E
T
E
I
S
Y
E
I
F
D
E
V
E
E
N
P
S
F
D
N
V
M
K
A
V
E
R
Y
R
N
D
S
F
D
F
V
V
G
L
G
G
G
S
P
M
D
F
A
K
A
V
A
V
L
L
K
E
--
K
D
L
S
V
E
D
---
L
Y
--
D
---
R
E
----
K
-
V
K
H
W
L
P
V
V
E
I
P
T
T
A
G
T
G
S
E
V
T
P
Y
S
I
L
T
D
P
E
-
G
N
K
R
G
C
--
T
L
M
F
P
V
Y
A
F
L
D
P
R
Y
T
Y
S
M
S
D
E
L
T
L
S
T
G
V
D
A
L
S
H
A
V
E
G
Y
L
S
R
K
S
T
-
P
P
------
S
D
A
L
A
I
E
A
M
K
I
I
H
R
N
L
P
K
-------
A
I
E
--
G
-
N
R
E
A
R
K
K
M
F
V
A
---
S
-
C
L
A
--
G
M
---
V
I
A
Q
T
G
T
T
-------------
L
A
H
A
L
G
Y
P
L
T
T
---
E
K
G
I
K
H
G
K
A
T
G
M
V
L
P
F
V
M
E
V
M
K
E
E
I
P
E
K
V
D
T
V
N
H
I
--
F
G
G
----------------
S
L
L
K
F
L
K
E
L
G
L
Y
E
K
V
---
A
V
S
S
E
E
L
E
K
W
V
E
----
K
G
S
R
A
---
K
H
--------
L
--
K
N
T
P
G
T
F
T
P
E
K
I
R
N
I
Y
R
E
A
L
12
PsiBlast_PDB
63.32
24%
-30
- C3 -
2BL4
3
FUCO_ECOLI
A:
[11-385]
---
M
A
N
R
M
I
L
N
E
T
A
W
-
F
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
-
Y
Q
-
K
A
L
I
V
T
D
K
-
T
L
V
-
Q
C
G
V
V
A
K
V
T
D
K
M
D
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
-
I
S
N
--
N
P
-
E
F
A
D
---
V
R
--
S
---
L
E
GLS
P
T
-
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
---------------
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
-------
I
I
A
G
-----
A
L
R
G
S
V
--
A
---
G
-
D
K
D
--
A
G
---
E
E
M
A
L
G
-
Q
Y
V
A
G
M
G
FSNV
G
L
G
L
V
H
G
M
A
H
P
L
G
A
---
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
-
R
V
-
M
G
V
K
V
E
G
M
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
K
E
D
I
P
A
L
A
Q
----
A
A
L
D
D
---
V
C
T
------
G
----
G
N
P
R
E
A
T
L
E
D
I
V
-------