@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu31980: (2016-07-23 )
MLKGFTPWPDELAETYRKNGCWAGETFGDLLRDRAAKYGDRIAITCGNTHWSYRELDTRADRLAAGFQKLGIQQMDRVVVQLPNIKEFFEVIFALFRLGALPVFALPSHRSSEITYFCEFAEAAAYIIPDAYSGFDYRSLARQVQSKLPTLKNIIVAGEAEEFLPLEDLHAEPVKLPEVKSSDVAFLQLSGGSTGLSKLIPRTHDDYIYSLKRSVEVCWLDHSTVYLAALPMAHNYPLSSPGVLGVLYAGGRVVLSPSPSPDDAFPLIEREKVTITALVPPLAMVWMDAASSRRDDLSSLQVLQVGGAKFSAEAARRVKAVFGCTLQQVFGMAEGLVNYTRLDDPEEIIVNTQGKPMSPYDEMRVWDDHDRDVKPGETGHLLTRGPYTIRGYYKAEEHNAASFTEDGFYRTGDIVRLTRDGYIVVEGRAKDQINRGGEKVAAEEVENHLLAHPAVHDAAMVSMPDQFLGERSCVFIIPRDEAPKAAELKAFLRERGLAAYKIPDRVEFVESFPQTGVGKVSKKALREAISEKLLAGFKK
Atome Classification :
(27 SA)
.........10........20........30........40....---....50.........60........70........80........90........100.......110.......120.......130--........140.......150..-.....--160.--...--.....---170..----......180.......190.......200......-.210..-.....220.......230.......240.......250.......260.......270.......280.......--290--.......300.......310.......320---.......330...----....340----........350.......360.......370.-.....-.380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLKGFTP
W
P
D
E
L
A
E
T
Y
R
KNGCWAG
E
T
F
G
D
L
L
R
D
R
A
A
KYG
D
R
I
A
I
T
---CGNTH-
W
S
Y
R
E
L
D
T
R
A
D
R
L
A
A
G
F
Q
KL
G
I
Q
Q
M
D
R
V
V
V
QLP
N
I
K
E
F
F
E
V
I
F
A
L
F
RLGA
L
P
V
F
ALPSHRSS
E
I
T
Y
F
C
E
F
A
EA
A
A
Y
IIPDA---YSGF
D
Y
R
S
L
A
R
Q
V
Q
S
KL
P
T
L
K
N
I
-
I
VAGE--A--E--EFL--
P
L
E
DL---H-AEP----VKLPEVKSS
D
V
A
F
L
Q
LSGGST
G
L
S
K
LIPRTH
D
D
Y
I
-
Y
S
L
K
RS-
V
E
V
C
W
LDHS
T
V
Y
L
A
ALPMAHNYPLSSP
G
V
L
G
V
L
YAG
G
R
V
V
L
SPSPSPDDAFP
L
I
ERE
K
V
T
I
T
A
LV
P
P
L
A
M
V
W
M
D
A--ASS--RRD
D
L
S
S
L
Q
V
L
QVGGAKF
S
A
E
A
A
R
R
V
K
A
V
F
---
G
C
T
L
Q
Q
V
F
G
M
A
E
G
----
L
V
N
YTR-----LD
D
P
E
E
I
I
VNTQGKPMS
P
Y
D
EMRVWDDHDRDV-KPGET-G
H
L
L
TRG
P
Y
T
I
R
G
Y
Y
K
AEEHNAASFTEDGFYRTG
D
I
V
R
LTRD
G
Y
I
V
VEGRA
K
D
Q
I
NRGGEK
V
A
A
E
E
V
E
N
H
LLAHPAVH
D
A
A
M
VS
M
P
D
Q
F
LGER
S
C
V
F
I
I
PRDEAP
K
A
A
E
L
K
A
F
L
R
ERGLAAYKIP
D
R
V
E
F
V
E
SFPQTG
V
G
K
V
S
K
K
A
L
R
E
A
I
S
E
K
L
L
A
GFKK
36
HHSearch
98.98
99%
-103
- C4 -
1MDB
4
DHBE_BACSU
A:
[1-536]
M
L
K
G
F
T
P
W
P
D
E
L
A
E
T
Y
R
K
N
G
C
W
A
G
E
T
F
G
D
L
L
R
D
R
A
A
K
Y
G
D
R
I
A
I
T
---
C
G
N
T
H
-
W
S
Y
R
E
L
D
T
R
A
D
R
L
A
A
G
F
Q
K
L
G
I
Q
Q
K
D
R
V
V
V
Q
L
P
N
I
K
E
F
F
E
V
I
F
A
L
F
R
L
G
A
L
P
V
F
A
L
P
S
H
R
S
S
E
I
T
Y
F
C
E
F
A
E
A
A
A
Y
I
I
P
D
A
---
Y
S
G
F
D
Y
R
S
L
A
R
Q
V
Q
S
K
L
P
T
L
K
N
I
-
I
V
A
G
E
--
A
--
E
--
E
F
L
--
P
L
E
D
L
---
H
-
T
E
P
----
V
K
L
P
E
V
K
S
S
D
V
A
F
L
Q
L
S
G
G
S
T
G
L
S
K
L
I
P
R
T
H
D
D
Y
I
-
Y
S
L
K
R
S
-
V
E
V
C
W
L
D
H
S
T
V
Y
L
A
A
L
P
M
A
H
N
Y
P
L
S
S
P
G
V
L
G
V
L
Y
A
G
G
R
V
V
L
S
P
S
P
S
P
D
D
A
F
P
L
I
E
R
E
K
V
T
I
T
A
L
V
P
P
L
A
M
V
W
M
D
A
--
A
S
S
--
R
R
D
D
L
S
S
L
Q
V
L
Q
V
G
G
A
K
F
S
A
E
A
A
R
R
V
K
A
V
F
---
G
C
T
L
Q
Q
V
F
G
M
A
E
G
----
L
V
N
Y
T
R
-----
L
D
D
P
E
E
I
I
V
N
T
Q
G
K
P
M
S
P
Y
D
E
S
R
V
W
D
D
H
D
R
D
V
-
K
P
G
E
T
-
G
H
L
L
T
R
G
P
Y
T
I
R
G
Y
Y
K
A
E
E
H
N
A
A
S
F
T
E
D
G
F
Y
R
T
G
D
I
V
R
L
T
R
D
G
Y
I
V
V
E
G
R
A
K
D
Q
I
N
R
G
G
E
K
V
A
A
E
E
V
E
N
H
L
L
A
H
P
A
V
H
D
A
A
M
V
S
M
P
D
Q
F
L
G
E
R
S
C
V
F
I
I
P
R
D
E
A
P
K
A
A
E
L
K
A
F
L
R
E
R
G
L
A
A
Y
K
I
P
D
R
V
E
F
V
E
S
F
P
Q
T
G
V
G
K
V
S
K
K
A
L
R
E
A
I
S
E
K
L
L
A
G
---
1
PsiBlast_PDB
98.98
99%
-103
- C4 -
1MDB
4
DHBE_BACSU
A:
[1-536]
M
L
K
G
F
T
P
W
P
D
E
L
A
E
T
Y
R
K
N
G
C
W
A
G
E
T
F
G
D
L
L
R
D
R
A
A
K
Y
G
D
R
I
A
I
T
---
C
G
N
T
H
-
W
S
Y
R
E
L
D
T
R
A
D
R
L
A
A
G
F
Q
K
L
G
I
Q
Q
K
D
R
V
V
V
Q
L
P
N
I
K
E
F
F
E
V
I
F
A
L
F
R
L
G
A
L
P
V
F
A
L
P
S
H
R
S
S
E
I
T
Y
F
C
E
F
A
E
A
A
A
Y
I
I
P
D
A
---
Y
S
G
F
D
Y
R
S
L
A
R
Q
V
Q
S
K
L
P
T
L
K
N
I
-
I
V
A
G
E
--
A
--
E
--
E
F
L
--
P
L
E
D
L
---
H
-
T
E
P
----
V
K
L
P
E
V
K
S
S
D
V
A
F
L
Q
L
S
G
G
S
T
G
L
S
K
L
I
P
R
T
H
D
D
Y
I
-
Y
S
L
K
R
S
-
V
E
V
C
W
L
D
H
S
T
V
Y
L
A
A
L
P
M
A
H
N
Y
P
L
S
S
P
G
V
L
G
V
L
Y
A
G
G
R
V
V
L
S
P
S
P
S
P
D
D
A
F
P
L
I
E
R
E
K
V
T
I
T
A
L
V
P
P
L
A
M
V
W
M
D
A
--
A
S
S
--
R
R
D
D
L
S
S
L
Q
V
L
Q
V
G
G
A
K
F
S
A
E
A
A
R
R
V
K
A
V
F
---
G
C
T
L
Q
Q
V
F
G
M
A
E
G
----
L
V
N
Y
T
R
-----
L
D
D
P
E
E
I
I
V
N
T
Q
G
K
P
M
S
P
Y
D
E
S
R
V
W
D
D
H
D
R
D
V
-
K
P
G
E
T
-
G
H
L
L
T
R
G
P
Y
T
I
R
G
Y
Y
K
A
E
E
H
N
A
A
S
F
T
E
D
G
F
Y
R
T
G
D
I
V
R
L
T
R
D
G
Y
I
V
V
E
G
R
A
K
D
Q
I
N
R
G
G
E
K
V
A
A
E
E
V
E
N
H
L
L
A
H
P
A
V
H
D
A
A
M
V
S
M
P
D
Q
F
L
G
E
R
S
C
V
F
I
I
P
R
D
E
A
P
K
A
A
E
L
K
A
F
L
R
E
R
G
L
A
A
Y
K
I
P
D
R
V
E
F
V
E
S
F
P
Q
T
G
V
G
K
V
S
K
K
A
L
R
E
A
I
S
E
K
L
L
A
G
---
2
PsiBlast_PDB
98.36
99%
-100
- C4 -
1MDF
2
DHBE_BACSU
A:
[1-536]
M
L
K
G
F
T
P
W
P
D
E
L
A
E
T
Y
R
K
N
G
C
W
A
G
E
T
F
G
D
L
L
R
D
R
A
A
K
Y
G
D
R
I
A
I
T
---
C
G
N
T
H
-
W
S
Y
R
E
L
D
T
R
A
D
R
L
A
A
G
F
Q
K
L
G
I
Q
Q
K
D
R
V
V
V
Q
L
P
N
I
K
E
F
F
E
V
I
F
A
L
F
R
L
G
A
L
P
V
F
A
L
P
S
H
R
S
S
E
I
T
Y
F
C
E
F
A
E
A
A
A
Y
I
I
P
D
A
---
Y
S
G
F
D
Y
R
S
L
A
R
Q
V
Q
S
K
L
P
T
L
K
N
I
-
I
V
A
G
E
--
A
--
E
--
E
F
L
--
P
L
E
D
L
---
H
-
T
E
P
----
V
K
L
P
E
V
K
S
S
D
V
A
F
L
Q
L
S
G
G
S
T
G
L
S
K
L
I
P
R
T
H
D
D
Y
I
-
Y
S
L
K
R
S
-
V
E
V
C
W
L
D
H
S
T
V
Y
L
A
A
L
P
M
A
H
N
Y
P
L
S
S
P
G
V
L
G
V
L
Y
A
G
G
R
V
V
L
S
P
S
P
S
P
D
D
A
F
P
L
I
E
R
E
K
V
T
I
T
A
L
V
P
P
L
A
M
V
W
M
D
A
--
A
S
S
--
R
R
D
D
L
S
S
L
Q
V
L
Q
V
G
G
A
K
F
S
A
E
A
A
R
R
V
K
A
V
F
---
G
C
T
L
Q
Q
V
F
G
M
A
E
G
----
L
V
N
Y
T
R
-----
L
D
D
P
E
E
I
I
V
N
T
Q
G
K
P
M
S
P
Y
D
E
S
R
V
W
D
D
H
D
R
D
V
-
K
P
G
E
T
-
G
H
L
L
T
R
G
P
Y
T
I
R
G
Y
Y
K
A
E
E
H
N
A
A
S
F
T
E
D
G
F
Y
R
T
G
D
I
V
R
L
T
R
D
G
Y
I
V
V
E
G
R
A
K
D
Q
I
N
R
G
G
E
K
V
A
A
E
E
V
E
N
H
L
L
A
H
P
A
V
H
D
A
A
M
V
S
M
P
D
Q
F
L
G
E
R
S
C
V
F
I
I
P
R
D
E
A
P
K
A
A
E
L
K
A
F
L
R
E
R
G
L
A
A
Y
K
I
P
D
R
V
E
F
V
E
S
F
P
Q
T
G
V
G
K
V
S
K
K
A
L
R
E
A
I
S
E
K
L
L
A
G
---
3
PsiBlast_PDB
97.24
98%
-100
- C4 -
1MD9
2
DHBE_BACSU
A:
[2-536]
-
L
K
G
F
T
P
W
P
D
E
L
A
E
T
Y
R
K
N
G
C
W
A
G
E
T
F
G
D
L
L
R
D
R
A
A
K
Y
G
D
R
I
A
I
T
---
C
G
N
T
H
-
W
S
Y
R
E
L
D
T
R
A
D
R
L
A
A
G
F
Q
K
L
G
I
Q
Q
K
D
R
V
V
V
Q
L
P
N
I
K
E
F
F
E
V
I
F
A
L
F
R
L
G
A
L
P
V
F
A
L
P
S
H
R
S
S
E
I
T
Y
F
C
E
F
A
E
A
A
A
Y
I
I
P
D
A
---
Y
S
G
F
D
Y
R
S
L
A
R
Q
V
Q
S
K
L
P
T
L
K
N
I
-
I
V
A
G
E
--
A
--
E
--
E
F
L
--
P
L
E
D
L
---
H
-
T
E
P
----
V
K
L
P
E
V
K
S
S
D
V
A
F
L
Q
L
S
G
G
S
T
G
L
S
K
L
I
P
R
T
H
D
D
Y
I
-
Y
S
L
K
R
S
-
V
E
V
C
W
L
D
H
S
T
V
Y
L
A
A
L
P
M
A
H
N
Y
P
L
S
S
P
G
V
L
G
V
L
Y
A
G
G
R
V
V
L
S
P
S
P
S
P
D
D
A
F
P
L
I
E
R
E
K
V
T
I
T
A
L
V
P
P
L
A
M
V
W
M
D
A
--
A
S
S
--
R
R
D
D
L
S
S
L
Q
V
L
Q
V
G
G
A
K
F
S
A
E
A
A
R
R
V
K
A
V
F
---
G
C
T
L
Q
Q
V
F
G
M
A
E
G
----
L
V
N
Y
T
R
-----
L
D
D
P
E
E
I
I
V
N
T
Q
G
K
P
M
S
P
Y
D
E
S
R
V
W
D
D
H
D
R
D
V
-
K
P
G
E
T
-
G
H
L
L
T
R
G
P
Y
T
I
R
G
Y
Y
K
A
E
E
H
N
A
A
S
F
T
E
D
G
F
Y
R
T
G
D
I
V
R
L
T
R
D
G
Y
I
V
V
E
G
R
A
K
D
Q
I
N
R
G
G
E
K
V
A
A
E
E
V
E
N
H
L
L
A
H
P
A
V
H
D
A
A
M
V
S
M
P
D
Q
F
L
G
E
R
S
C
V
F
I
I
P
R
D
E
A
P
K
A
A
E
L
K
A
F
L
R
E
R
G
L
A
A
Y
K
I
P
D
R
V
E
F
V
E
S
F
P
Q
T
G
V
G
K
V
S
K
K
A
L
R
E
A
I
S
E
K
L
L
A
G
---
40
HHSearch
70.30
48%
-41
- C4 -
4IZ6
2
ENTE_ECOLI
A:
[24-556]
---
P
F
T
R
W
P
E
E
F
A
R
R
Y
R
E
K
G
Y
W
Q
D
L
P
L
T
D
I
L
T
R
H
A
A
--
S
D
S
I
A
V
I
---
D
G
E
R
Q
-
L
S
Y
R
E
L
N
Q
A
A
D
N
L
A
C
S
L
R
R
Q
G
I
K
P
G
E
T
A
L
V
Q
L
G
N
V
A
E
L
Y
I
T
F
F
A
L
L
K
L
G
V
A
P
V
L
A
L
F
S
H
Q
R
S
E
L
N
A
Y
A
S
Q
I
E
P
A
L
L
I
A
D
R
Q
---
H
A
L
F
S
G
D
D
F
L
N
T
F
V
T
E
H
S
S
I
R
V
V
-
Q
L
L
N
D
-----
S
--
G
E
H
--
N
L
Q
D
A
I
N
H
P
-
A
E
D
----
F
T
A
T
P
S
P
A
D
E
V
A
Y
F
Q
L
S
G
G
-
T
G
T
P
K
L
I
P
R
T
H
N
D
Y
Y
-
Y
S
V
R
R
S
-
V
E
I
C
Q
F
T
Q
Q
T
R
Y
L
C
A
I
P
A
A
H
N
Y
A
M
S
S
P
G
S
L
G
V
F
L
A
G
G
T
V
V
L
A
A
D
P
S
A
T
L
C
F
P
L
I
E
K
H
Q
V
N
V
T
A
L
V
P
P
A
V
S
L
W
L
Q
A
--
L
I
E
GE
S
R
A
Q
L
A
S
L
K
L
L
Q
V
G
G
A
R
L
S
A
T
L
A
A
R
I
P
A
E
I
---
G
C
Q
L
Q
Q
V
F
G
M
A
E
G
----
L
V
N
Y
T
R
-----
L
D
D
S
A
E
K
I
I
H
T
Q
G
Y
P
M
C
P
D
D
E
V
W
V
A
D
A
E
G
N
P
L
-
P
Q
G
E
V
-
G
R
L
M
T
R
G
P
Y
T
F
R
G
Y
Y
K
S
P
Q
H
N
A
S
A
F
D
A
N
G
F
Y
C
S
G
D
L
I
S
I
D
P
E
G
Y
I
T
V
Q
G
R
E
K
D
Q
I
N
R
G
G
E
K
I
A
A
E
E
I
E
N
L
L
L
R
H
P
A
V
I
Y
A
A
L
V
S
M
E
D
E
L
M
G
E
K
S
C
A
Y
L
V
V
K
E
P
-
L
R
A
V
Q
V
R
R
F
L
R
E
Q
G
I
A
E
F
K
L
P
D
R
V
E
C
V
D
S
L
P
L
T
A
V
G
K
V
D
K
K
Q
L
R
Q
W
L
A
S
--------
23
PsiBlast_CBE
66.78
48%
-22
- C4 -
3RG2
1
ENTB_ECOLI (first)
I:
[7-539]
----
F
T
R
W
P
E
E
F
A
R
R
Y
R
E
K
G
Y
W
Q
D
L
P
L
T
D
I
L
T
R
H
A
A
S
--
D
S
I
A
V
I
---
D
G
E
R
Q
-
L
S
Y
R
E
L
N
Q
A
A
D
N
L
A
C
S
L
R
R
Q
G
I
K
P
G
E
T
A
L
V
Q
L
G
N
V
A
E
L
Y
I
T
F
F
A
L
L
K
L
G
V
A
P
V
L
A
L
F
S
H
Q
R
S
E
L
N
A
Y
A
S
Q
I
E
P
A
L
L
I
A
D
R
Q
HAL
F
S
G
D
D
F
L
N
T
F
V
T
E
H
S
S
I
R
V
V
Q
L
L
-
N
D
S
G
E
HN
L
--
Q
--
D
A
I
NH
P
A
E
D
F
---
T
---
P
----
S
P
-----
A
D
E
V
A
Y
F
Q
L
S
G
G
-
T
G
T
P
K
L
I
P
R
T
H
N
D
Y
Y
-
Y
S
V
R
R
S
-
V
E
I
C
Q
F
T
Q
Q
T
R
Y
L
C
A
I
P
A
A
H
N
Y
A
M
S
S
P
G
S
L
G
V
F
L
A
G
G
T
V
V
L
A
A
D
P
S
A
T
L
C
F
P
L
I
E
K
H
Q
V
N
V
T
A
L
V
P
P
A
V
S
L
W
L
Q
A
LI
E
G
E
--
S
R
A
Q
L
A
S
L
K
L
L
Q
V
G
G
A
R
L
S
A
T
L
A
A
R
I
P
A
E
I
---
G
C
Q
L
Q
Q
V
F
G
M
A
E
G
----
L
V
N
Y
T
R
-----
L
D
D
S
A
E
K
I
I
H
T
Q
G
Y
P
M
C
P
D
D
E
V
W
V
A
D
A
E
G
N
P
L
-
P
Q
G
E
V
-
G
R
L
M
T
R
G
P
Y
T
F
R
G
Y
Y
K
S
P
Q
H
N
A
S
A
F
D
A
N
G
F
Y
C
S
G
D
L
I
S
I
D
P
E
G
Y
I
T
V
Q
G
R
E
K
D
Q
I
N
R
G
G
E
K
I
A
A
E
E
I
E
N
L
L
L
R
H
P
A
V
I
Y
A
A
L
V
S
M
E
D
E
L
M
G
E
K
S
C
A
Y
L
V
V
K
-
E
P
L
R
A
V
Q
V
R
R
F
L
R
E
Q
G
I
A
E
F
K
L
P
D
R
V
E
C
V
D
S
L
P
L
T
A
V
G
K
V
D
K
K
Q
L
R
Q
W
L
A
S
R
A
S
A
G
---
5
PsiBlast_PDB
66.74
48%
-19
- C4 -
3RG2
2
ENTB_ECOLI (first)
A:
[7-539]
----
F
T
R
W
P
E
E
F
A
R
R
Y
R
E
K
G
Y
W
Q
D
L
P
L
T
D
I
L
T
R
H
A
A
S
--
D
S
I
A
V
I
---
D
G
E
R
Q
-
L
S
Y
R
E
L
N
Q
A
A
D
N
L
A
C
S
L
R
R
Q
G
I
K
P
G
E
T
A
L
V
Q
L
G
N
V
A
E
L
Y
I
T
F
F
A
L
L
K
L
G
V
A
P
V
L
A
L
F
S
H
Q
R
S
E
L
N
A
Y
A
S
Q
I
E
P
A
L
L
I
A
D
R
Q
HAL
F
S
G
D
D
F
L
N
T
F
V
T
E
H
S
S
I
R
V
V
Q
L
L
-
N
D
S
G
E
HN
L
--
Q
--
D
A
I
N
H
P
A
E
D
F
---
T
-
A
T
P
----
S
P
-----
A
D
E
V
A
Y
F
Q
L
S
G
G
T
T
G
T
P
K
L
I
P
R
T
H
N
D
Y
Y
-
Y
S
V
R
R
S
-
V
E
I
C
Q
F
T
Q
Q
T
R
Y
L
C
A
I
P
A
A
H
N
Y
A
M
S
S
P
G
S
L
G
V
F
L
A
G
G
T
V
V
L
A
A
D
P
S
A
T
L
C
F
P
L
I
E
K
H
Q
V
N
V
T
A
L
V
P
P
A
V
S
L
W
L
Q
A
L
I
E
G
E
--
S
R
A
Q
L
A
S
L
K
L
L
Q
V
G
G
A
R
L
S
A
T
L
A
A
R
I
P
A
E
I
---
G
C
Q
L
Q
Q
V
F
G
M
A
E
G
----
L
V
N
Y
T
R
-----
L
D
D
S
A
E
K
I
I
H
T
Q
G
Y
P
M
C
P
D
D
E
V
W
V
A
D
A
E
G
N
P
L
-
P
Q
G
E
V
-
G
R
L
M
T
R
G
P
Y
T
F
R
G
Y
Y
K
S
P
Q
H
N
A
S
A
F
D
A
N
G
F
Y
C
S
G
D
L
I
S
I
D
P
E
G
Y
I
T
V
Q
G
R
E
K
D
Q
I
N
R
G
G
E
K
I
A
A
E
E
I
E
N
L
L
L
R
H
P
A
V
I
Y
A
A
L
V
S
M
E
D
E
L
M
G
E
K
S
C
A
Y
L
V
V
K
-
E
P
L
R
A
V
Q
V
R
R
F
L
R
E
Q
G
I
A
E
F
K
L
P
D
R
V
E
C
V
D
S
L
P
L
T
A
V
G
K
V
D
K
K
Q
L
R
Q
W
L
A
S
R
A
S
A
G
---
28
PsiBlast_CBE
66.72
48%
-21
- C4 -
3RG2
2
ENTB_ECOLI (first)
C:
[7-539]
----
F
T
R
W
P
E
E
F
A
R
R
Y
R
E
K
G
Y
W
Q
D
L
P
L
T
D
I
L
T
R
H
A
A
S
--
D
S
I
A
V
I
---
D
G
E
R
Q
-
L
S
Y
R
E
L
N
Q
A
A
D
N
L
A
C
S
L
R
R
Q
G
I
K
P
G
E
T
A
L
V
Q
L
G
N
V
A
E
L
Y
I
T
F
F
A
L
L
K
L
G
V
A
P
V
L
A
L
F
S
H
Q
R
S
E
L
N
A
Y
A
S
Q
I
E
P
A
L
L
I
A
D
R
Q
HAL
F
S
G
D
D
F
L
N
T
F
V
T
E
H
S
S
I
R
V
V
Q
L
L
-
N
D
S
G
E
HN
L
--
Q
--
D
A
I
N
H
P
A
E
D
F
---
T
-
A
T
P
----
S
P
-----
A
D
E
V
A
Y
F
Q
L
S
G
G
T
T
G
T
P
K
L
I
P
R
T
H
N
D
Y
Y
-
Y
S
V
R
R
S
-
V
E
I
C
Q
F
T
Q
Q
T
R
Y
L
C
A
I
P
A
A
H
N
Y
A
M
S
S
P
G
S
L
G
V
F
L
A
G
G
T
V
V
L
A
A
D
P
S
A
T
L
C
F
P
L
I
E
K
H
Q
V
N
V
T
A
L
V
P
P
A
V
S
L
W
L
Q
A
L
I
E
G
E
--
S
R
A
Q
L
A
S
L
K
L
L
Q
V
G
G
A
R
L
S
A
T
L
A
A
R
I
P
A
E
I
---
G
C
Q
L
Q
Q
V
F
G
M
A
E
G
----
L
V
N
Y
T
R
-----
L
D
D
S
A
E
K
I
I
H
T
Q
G
Y
P
M
C
P
D
D
E
V
W
V
A
D
A
E
G
N
P
L
-
P
Q
G
E
V
-
G
R
L
M
T
R
G
P
Y
T
F
R
G
Y
Y
K
S
P
Q
H
N
A
S
A
F
D
A
N
G
F
Y
C
S
G
D
L
I
S
I
D
P
E
G
Y
I
T
V
Q
G
R
E
K
D
Q
I
N
R
G
G
E
K
I
A
A
E
E
I
E
N
L
L
L
R
H
P
A
V
I
Y
A
A
L
V
S
M
E
D
E
L
M
G
E
K
S
C
A
Y
L
V
V
K
-
E
P
L
R
A
V
Q
V
R
R
F
L
R
E
Q
G
I
A
E
F
K
L
P
D
R
V
E
C
V
D
S
L
P
L
T
A
V
G
K
V
D
K
K
Q
L
R
Q
W
L
A
S
R
A
S
A
G
---
26
PsiBlast_CBE
66.72
48%
-22
- C4 -
3RG2
2
ENTB_ECOLI (first)
E:
[7-539]
----
F
T
R
W
P
E
E
F
A
R
R
Y
R
E
K
G
Y
W
Q
D
L
P
L
T
D
I
L
T
R
H
A
A
S
--
D
S
I
A
V
I
---
D
G
E
R
Q
-
L
S
Y
R
E
L
N
Q
A
A
D
N
L
A
C
S
L
R
R
Q
G
I
K
P
G
E
T
A
L
V
Q
L
G
N
V
A
E
L
Y
I
T
F
F
A
L
L
K
L
G
V
A
P
V
L
A
L
F
S
H
Q
R
S
E
L
N
A
Y
A
S
Q
I
E
P
A
L
L
I
A
D
R
Q
HAL
F
S
G
D
D
F
L
N
T
F
V
T
E
H
S
S
I
R
V
V
Q
L
L
-
N
D
S
G
E
H
N
L
--
Q
--
D
A
I
NH
P
A
E
D
F
---
T
-
A
T
P
----
S
P
-----
A
D
E
V
A
Y
F
Q
L
S
--
T
T
G
T
P
K
L
I
P
R
T
H
N
D
Y
Y
-
Y
S
V
R
R
S
-
V
E
I
C
Q
F
T
Q
Q
T
R
Y
L
C
A
I
P
A
A
H
N
Y
A
M
S
S
P
G
S
L
G
V
F
L
A
G
G
T
V
V
L
A
A
D
P
S
A
T
L
C
F
P
L
I
E
K
H
Q
V
N
V
T
A
L
V
P
P
A
V
S
L
W
L
Q
A
L
I
E
G
E
--
S
R
A
Q
L
A
S
L
K
L
L
Q
V
G
G
A
R
L
S
A
T
L
A
A
R
I
P
A
E
I
---
G
C
Q
L
Q
Q
V
F
G
M
A
E
G
----
L
V
N
Y
T
R
-----
L
D
D
S
A
E
K
I
I
H
T
Q
G
Y
P
M
C
P
D
D
E
V
W
V
A
D
A
E
G
N
P
L
-
P
Q
G
E
V
-
G
R
L
M
T
R
G
P
Y
T
F
R
G
Y
Y
K
S
P
Q
H
N
A
S
A
F
D
A
N
G
F
Y
C
S
G
D
L
I
S
I
D
P
E
G
Y
I
T
V
Q
G
R
E
K
D
Q
I
N
R
G
G
E
K
I
A
A
E
E
I
E
N
L
L
L
R
H
P
A
V
I
Y
A
A
L
V
S
M
E
D
E
L
M
G
E
K
S
C
A
Y
L
V
V
K
-
E
P
L
R
A
V
Q
V
R
R
F
L
R
E
Q
G
I
A
E
F
K
L
P
D
R
V
E
C
V
D
S
L
P
L
T
A
V
G
K
V
D
K
K
Q
L
R
Q
W
L
A
S
R
A
S
A
G
---
27
PsiBlast_CBE
66.69
48%
-22
- C4 -
3RG2
2
ENTB_ECOLI (first)
D:
[7-539]
----
F
T
R
W
P
E
E
F
A
R
R
Y
R
E
K
G
Y
W
Q
D
L
P
L
T
D
I
L
T
R
H
A
A
S
--
D
S
I
A
V
I
---
D
G
E
R
Q
-
L
S
Y
R
E
L
N
Q
A
A
D
N
L
A
C
S
L
R
R
Q
G
I
K
P
G
E
T
A
L
V
Q
L
G
N
V
A
E
L
Y
I
T
F
F
A
L
L
K
L
G
V
A
P
V
L
A
L
F
S
H
Q
R
S
E
L
N
A
Y
A
S
Q
I
E
P
A
L
L
I
A
D
R
Q
HAL
F
S
G
D
D
F
L
N
T
F
V
T
E
H
S
S
I
R
V
V
Q
L
L
-
N
D
S
G
E
HN
L
--
Q
--
D
A
I
N
H
P
A
E
D
F
---
T
-
A
T
P
----
S
P
-----
A
D
E
V
A
Y
F
Q
L
S
G
--
T
G
T
P
K
L
I
P
R
T
H
N
D
Y
Y
-
Y
S
V
R
R
S
-
V
E
I
C
Q
F
T
Q
Q
T
R
Y
L
C
A
I
P
A
A
H
N
Y
A
M
S
S
P
G
S
L
G
V
F
L
A
G
G
T
V
V
L
A
A
D
P
S
A
T
L
C
F
P
L
I
E
K
H
Q
V
N
V
T
A
L
V
P
P
A
V
S
L
W
L
Q
A
L
I
E
G
E
--
S
R
A
Q
L
A
S
L
K
L
L
Q
V
G
G
A
R
L
S
A
T
L
A
A
R
I
P
A
E
I
---
G
C
Q
L
Q
Q
V
F
G
M
A
E
G
----
L
V
N
Y
T
R
-----
L
D
D
S
A
E
K
I
I
H
T
Q
G
Y
P
M
C
P
D
D
E
V
W
V
A
D
A
E
G
N
P
L
-
P
Q
G
E
V
-
G
R
L
M
T
R
G
P
Y
T
F
R
G
Y
Y
K
S
P
Q
H
N
A
S
A
F
D
A
N
G
F
Y
C
S
G
D
L
I
S
I
D
P
E
G
Y
I
T
V
Q
G
R
E
K
D
Q
I
N
R
G
G
E
K
I
A
A
E
E
I
E
N
L
L
L
R
H
P
A
V
I
Y
A
A
L
V
S
M
E
D
E
L
M
G
E
K
S
C
A
Y
L
V
V
K
-
E
P
L
R
A
V
Q
V
R
R
F
L
R
E
Q
G
I
A
E
F
K
L
P
D
R
V
E
C
V
D
S
L
P
L
T
A
V
G
K
V
D
K
K
Q
L
R
Q
W
L
A
S
R
A
S
A
G
---
21
PsiBlast_CBE
66.51
48%
-24
- C4 -
4IZ6
2
ENTE_ECOLI
B:
[25-557]
----
F
T
R
W
P
E
E
F
A
R
R
Y
R
E
K
G
Y
W
Q
D
L
P
L
T
D
I
L
T
R
H
A
A
S
--
D
S
I
A
V
I
---
D
G
E
R
Q
-
L
S
Y
R
E
L
N
Q
A
A
D
N
L
A
C
S
L
R
R
Q
G
I
K
P
G
E
T
A
L
V
Q
L
G
N
V
A
E
L
Y
I
T
F
F
A
L
L
K
L
G
V
A
P
V
L
A
L
F
S
H
Q
R
S
E
L
N
A
Y
A
S
Q
I
E
P
A
L
L
I
A
D
R
Q
HAL
F
S
G
D
D
F
L
N
T
F
V
T
E
H
S
S
I
R
V
V
Q
L
L
-
N
D
S
G
E
HN
L
--
Q
--
D
A
I
N
H
P
A
E
D
F
---
T
-
A
T
P
----
S
P
-----
A
D
E
V
A
Y
F
Q
L
S
G
--
T
G
T
P
K
L
I
P
R
T
H
N
D
Y
Y
-
Y
S
V
R
R
S
-
V
E
I
C
Q
F
T
Q
Q
T
R
Y
L
C
A
I
P
A
A
H
N
Y
A
M
S
S
P
G
S
L
G
V
F
L
A
G
G
T
V
V
L
A
A
D
P
S
A
T
L
C
F
P
L
I
E
K
H
Q
V
N
V
T
A
L
V
P
P
A
V
S
L
W
L
Q
A
L
I
E
G
E
--
S
R
A
Q
L
A
S
L
K
L
L
Q
V
G
G
A
R
L
S
A
T
L
A
A
R
I
P
A
E
I
---
G
C
Q
L
Q
Q
V
F
G
M
A
E
G
----
L
V
N
Y
T
R
-----
L
D
D
S
A
E
K
I
I
H
T
Q
G
Y
P
M
C
P
D
D
E
V
W
V
A
D
A
E
G
N
P
L
-
P
Q
G
E
V
-
G
R
L
M
T
R
G
P
Y
T
F
R
G
Y
Y
K
S
P
Q
H
N
A
S
A
F
D
A
N
G
F
Y
C
S
G
D
L
I
S
I
D
P
E
G
Y
I
T
V
Q
G
R
E
K
D
Q
I
N
R
G
G
E
K
I
A
A
E
E
I
E
N
L
L
L
R
H
P
A
V
I
Y
A
A
L
V
S
M
E
D
E
L
M
G
E
K
S
C
A
Y
L
V
V
K
-
E
P
L
R
A
V
Q
V
R
R
F
L
R
E
Q
G
I
A
E
F
K
L
P
D
R
V
E
C
V
D
S
L
P
L
T
A
V
G
K
V
D
K
K
Q
L
R
Q
W
L
A
S
R
A
S
A
G
---
4
PsiBlast_PDB
66.42
48%
0
- C- -
4IZ6
2
ENTE_ECOLI
A:
[25-561]
----
F
T
R
W
P
E
E
F
A
R
R
Y
R
E
K
G
Y
W
Q
D
L
P
L
T
D
I
L
T
R
H
A
A
S
--
D
S
I
A
V
I
---
D
G
E
R
Q
-
L
S
Y
R
E
L
N
Q
A
A
D
N
L
A
C
S
L
R
R
Q
G
I
K
P
G
E
T
A
L
V
Q
L
G
N
V
A
E
L
Y
I
T
F
F
A
L
L
K
L
G
V
A
P
V
L
A
L
F
S
H
Q
R
S
E
L
N
A
Y
A
S
Q
I
E
P
A
L
L
I
A
D
R
Q
HAL
F
S
G
D
D
F
L
N
T
F
V
T
E
H
S
S
I
R
V
V
Q
L
L
-
N
D
S
G
E
HN
L
--
Q
--
D
A
I
N
H
P
A
E
D
F
---
T
-
A
T
P
----
S
P
-----
A
D
E
V
A
Y
F
Q
L
S
G
G
-
T
G
T
P
K
L
I
P
R
T
H
N
D
Y
Y
-
Y
S
V
R
R
S
-
V
E
I
C
Q
F
T
Q
Q
T
R
Y
L
C
A
I
P
A
A
H
N
Y
A
M
S
S
P
G
S
L
G
V
F
L
A
G
G
T
V
V
L
A
A
D
P
S
A
T
L
C
F
P
L
I
E
K
H
Q
V
N
V
T
A
L
V
P
P
A
V
S
L
W
L
Q
A
L
I
E
G
E
--
S
R
A
Q
L
A
S
L
K
L
L
Q
V
G
G
A
R
L
S
A
T
L
A
A
R
I
P
A
E
I
---
G
C
Q
L
Q
Q
V
F
G
M
A
E
G
----
L
V
N
Y
T
R
-----
L
D
D
S
A
E
K
I
I
H
T
Q
G
Y
P
M
C
P
D
D
E
V
W
V
A
D
A
E
G
N
P
L
-
P
Q
G
E
V
-
G
R
L
M
T
R
G
P
Y
T
F
R
G
Y
Y
K
S
P
Q
H
N
A
S
A
F
D
A
N
G
F
Y
C
S
G
D
L
I
S
I
D
P
E
G
Y
I
T
V
Q
G
R
E
K
D
Q
I
N
R
G
G
E
K
I
A
A
E
E
I
E
N
L
L
L
R
H
P
A
V
I
Y
A
A
L
V
S
M
E
D
E
L
M
G
E
K
S
C
A
Y
L
V
V
K
-
E
P
L
R
A
V
Q
V
R
R
F
L
R
E
Q
G
I
A
E
F
K
L
P
D
R
V
E
C
V
D
S
L
P
L
T
A
V
G
K
V
D
K
K
Q
L
R
Q
W
L
A
S
R
A
S
A
G
---
25
PsiBlast_CBE
66.02
48%
0
- C- -
3RG2
1
ENTB_ECOLI (first)
G:
[7-542]
----
F
T
R
W
P
E
E
F
A
R
R
Y
R
E
K
G
Y
W
Q
D
L
P
L
T
D
I
L
T
R
H
A
A
S
--
D
S
I
A
V
I
---
D
G
E
R
Q
-
L
S
Y
R
E
L
N
Q
A
A
D
N
L
A
C
S
L
R
R
Q
-
I
K
P
G
E
T
A
L
V
Q
L
G
N
V
A
E
L
Y
I
T
F
F
A
L
L
K
L
G
V
A
P
V
L
A
L
F
S
H
Q
R
S
E
L
N
A
Y
A
S
Q
I
E
P
A
L
L
I
A
D
R
Q
HAL
F
S
G
D
D
F
L
N
T
F
V
T
E
H
S
S
I
R
V
V
Q
L
L
-
N
D
S
G
E
HN
L
--
Q
--
D
A
I
N
H
P
A
E
D
F
---
T
-
A
T
P
----
S
P
-----
A
D
E
V
A
Y
F
Q
L
S
G
G
T
T
G
T
-
K
L
I
P
R
T
H
N
D
Y
Y
-
Y
S
V
R
R
S
-
V
E
I
C
Q
F
T
Q
Q
T
R
Y
L
C
A
I
P
A
A
H
N
Y
A
M
S
S
P
G
S
L
G
V
F
L
A
G
G
T
V
V
L
A
A
D
P
S
A
T
L
C
F
P
L
I
E
K
H
Q
V
N
V
T
A
L
V
P
P
A
V
S
L
W
L
Q
A
L
I
E
G
E
--
S
R
A
Q
L
A
S
L
K
L
L
Q
V
G
G
A
R
L
S
A
T
L
A
A
R
I
P
A
E
I
---
G
C
Q
L
Q
Q
V
F
G
M
A
E
G
----
L
V
N
Y
T
R
-----
L
D
D
S
A
E
K
I
I
H
T
Q
G
Y
P
M
C
P
D
D
E
V
W
V
A
--
E
G
N
P
L
-
P
Q
G
E
V
-
G
R
L
M
T
R
G
P
Y
T
F
R
G
Y
Y
K
S
P
Q
H
N
A
S
A
F
D
A
N
G
F
Y
C
S
G
D
L
I
S
I
D
P
E
G
Y
I
T
V
Q
G
R
E
K
D
Q
I
N
R
G
G
E
K
I
A
A
E
E
I
E
N
L
L
L
R
H
P
A
V
I
Y
A
A
L
V
S
M
E
D
E
L
M
G
E
K
S
C
A
Y
L
V
V
K
-
E
P
L
R
A
V
Q
V
R
R
F
L
R
E
Q
G
I
A
E
F
K
L
P
D
R
V
E
C
V
D
S
L
P
L
T
A
V
G
K
V
D
K
K
Q
L
R
Q
W
L
A
S
R
A
S
A
G
---
24
PsiBlast_CBE
65.79
48%
-18
- C4 -
3RG2
2
ENTB_ECOLI (first)
H:
[7-539]
----
F
T
R
W
P
E
E
F
A
R
R
Y
R
E
K
G
Y
W
Q
D
L
P
L
T
D
I
L
T
R
H
A
A
S
--
D
S
I
A
V
I
---
D
G
E
R
Q
-
L
S
Y
R
E
L
N
Q
A
A
D
N
L
A
C
S
L
R
R
Q
G
I
K
P
G
E
T
A
L
V
Q
L
G
N
V
A
E
L
Y
I
T
F
F
A
L
L
K
L
G
V
A
P
V
L
A
L
F
S
H
Q
R
S
E
L
N
A
Y
A
S
Q
I
E
P
A
L
L
I
A
D
R
Q
HAL
F
S
G
D
D
F
L
N
T
F
V
T
E
H
S
S
I
R
V
V
Q
L
L
-
N
D
S
G
E
HN
L
--
Q
--
D
A
I
N
H
P
A
E
D
----
T
-
A
T
P
----
S
P
-----
A
D
E
V
A
Y
F
Q
L
S
G
G
T
T
G
T
P
K
L
I
P
R
T
H
N
D
Y
Y
-
Y
S
V
R
R
S
-
V
E
I
C
Q
F
T
Q
Q
T
R
Y
L
C
A
I
P
A
A
H
N
Y
A
M
S
S
P
G
S
L
G
V
F
L
A
G
G
T
V
V
L
A
A
D
P
S
A
T
L
C
F
P
L
I
E
K
H
Q
V
N
V
T
A
L
V
P
P
A
V
S
L
W
L
Q
A
L
I
E
G
E
--
S
R
A
Q
L
A
S
L
K
L
L
Q
V
G
G
A
R
L
S
A
T
L
A
A
R
I
P
A
E
I
---
G
C
Q
L
Q
Q
V
F
G
M
A
E
G
----
L
V
N
Y
T
R
-----
L
D
D
S
A
E
K
I
I
H
T
Q
G
Y
P
M
C
P
D
D
E
V
W
V
A
D
A
E
G
N
P
L
-
P
Q
G
E
V
-
G
R
L
M
T
R
G
P
Y
T
F
R
G
Y
Y
K
S
P
Q
H
N
A
S
A
F
D
A
N
G
F
Y
C
S
G
D
L
I
S
I
D
P
E
G
Y
I
T
V
Q
G
R
E
K
D
Q
I
N
R
G
G
E
K
I
A
A
E
E
I
E
N
L
L
L
R
H
P
A
V
I
Y
A
A
L
V
S
M
E
D
E
L
M
G
E
K
S
C
A
Y
L
V
V
K
-
E
P
L
R
A
V
Q
V
R
R
F
L
R
E
Q
G
I
A
E
F
K
L
P
D
R
V
E
C
V
D
S
L
P
L
T
A
V
G
K
V
D
K
K
Q
L
R
Q
W
L
A
S
R
A
S
A
G
---
22
PsiBlast_CBE
65.74
48%
-23
- C4 -
3RG2
15
ENTB_ECOLI (first)
J:
[7-539]
----
F
T
R
W
P
E
E
F
A
R
R
Y
R
E
K
G
Y
W
Q
D
L
P
L
T
D
I
L
T
R
H
A
A
S
--
D
S
I
A
V
I
---
D
G
E
R
Q
-
L
S
Y
R
E
L
N
Q
A
A
D
N
L
A
C
S
L
R
R
Q
G
I
K
P
G
E
T
A
L
V
Q
L
G
N
V
A
E
L
Y
I
T
F
F
A
L
L
K
L
G
V
A
P
V
L
A
L
F
S
H
Q
R
S
E
L
N
A
Y
A
S
Q
I
E
P
A
L
L
I
A
D
R
Q
HAL
F
S
G
D
D
F
L
N
T
F
V
T
E
H
S
S
I
R
V
V
Q
L
L
-
N
D
S
G
E
HN
L
--
Q
--
D
A
I
NH
P
A
E
D
F
---
T
-
A
T
P
----
S
P
-----
A
D
E
V
A
Y
F
Q
L
S
G
G
-
T
G
T
P
K
L
I
P
R
T
H
N
D
Y
Y
-
Y
S
V
R
R
S
-
V
E
I
C
Q
F
T
Q
Q
T
R
Y
L
C
A
I
P
A
A
H
N
Y
A
M
S
S
P
G
S
L
G
V
F
L
A
G
G
T
V
V
L
A
A
D
P
S
A
T
L
C
F
P
L
I
E
K
H
Q
V
N
V
T
A
L
V
P
P
A
V
S
L
W
L
Q
A
LI
E
G
E
--
S
R
A
Q
L
A
S
L
K
L
L
Q
V
G
G
A
R
L
S
A
T
L
A
A
R
I
P
A
E
I
---
G
C
Q
L
Q
Q
V
F
G
M
A
E
G
----
L
V
N
Y
T
R
-----
L
D
D
S
A
E
K
I
I
H
T
Q
G
Y
P
M
C
P
D
D
E
V
W
V
A
D
A
E
G
N
P
L
--
Q
G
E
V
--
R
L
M
T
R
G
P
Y
T
F
R
G
Y
Y
K
S
P
Q
H
N
A
S
A
F
D
A
N
G
F
Y
C
S
G
D
L
I
S
I
D
P
E
---
T
V
Q
G
R
E
K
D
Q
I
N
R
G
G
E
K
I
A
A
E
E
I
E
N
L
L
L
R
H
P
A
V
I
Y
A
A
L
V
S
M
E
D
E
L
M
G
E
K
S
C
A
Y
L
V
V
K
-
E
P
L
R
A
V
Q
V
R
R
F
L
R
E
Q
G
I
A
E
F
K
L
P
D
R
V
E
C
V
D
S
L
P
L
T
A
V
G
K
V
D
K
K
Q
L
R
Q
W
L
A
S
R
A
S
A
G
---
33
PsiBlast_CBE
65.12
44%
-46
- C4 -
3O82
3
?
B:
[10-440]
----
F
V
R
W
S
P
E
R
A
Q
H
Y
R
N
K
G
Y
W
I
D
Q
P
L
T
R
I
L
T
V
G
V
Q
S
H
P
H
S
L
A
I
I
---
C
G
E
R
Q
-
L
S
Y
I
E
L
D
R
L
S
T
N
L
A
T
R
L
A
E
K
G
L
G
K
G
D
T
A
L
V
Q
L
P
N
V
A
E
F
Y
I
V
F
F
A
L
L
K
A
G
V
V
V
L
N
A
L
Y
S
H
R
Q
Y
E
L
N
A
F
I
K
Q
I
Q
P
K
L
L
I
G
S
R
Q
---
H
E
V
F
S
N
N
Q
F
I
D
S
L
H
D
V
N
L
S
P
E
I
I
-
L
M
L
N
H
--
Q
--
A
--
T
D
F
--
G
L
L
D
W
---
I
-
E
T
P
AE
T
F
V
D
F
S
S
T
P
A
D
E
V
A
F
F
Q
L
S
G
G
S
T
G
T
P
K
L
I
P
R
T
H
N
D
Y
D
-
Y
S
V
R
A
S
-
A
E
I
C
G
L
N
S
N
T
R
L
L
C
A
L
P
A
P
H
N
F
M
L
S
S
P
G
A
L
G
V
L
H
A
G
G
C
V
V
M
A
P
N
P
E
P
L
N
C
F
S
I
I
Q
R
H
Q
V
N
M
A
S
L
V
P
S
A
V
I
M
W
L
E
K
--
A
A
Q
--
Y
K
D
Q
I
Q
S
L
K
L
L
Q
V
G
G
A
S
F
P
E
S
L
A
R
Q
V
P
E
V
L
---
N
C
K
L
Q
Q
V
F
G
M
A
E
G
----
L
V
N
Y
T
R
-----
L
D
D
S
D
E
Q
I
F
T
T
Q
G
R
P
I
S
S
D
D
E
I
K
I
V
D
E
Q
Y
R
E
V
-
P
E
G
E
I
-
G
M
L
A
T
R
G
P
Y
T
F
C
G
Y
Y
Q
S
P
E
H
N
S
Q
V
F
D
E
D
N
Y
Y
Y
S
G
D
L
V
Q
R
T
P
D
G
N
L
R
V
V
G
R
I
K
D
------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
64.94
44%
-47
- C4 -
3O84
4
?
B:
[10-440]
----
F
V
R
W
S
P
E
R
A
Q
H
Y
R
N
K
G
Y
W
I
D
Q
P
L
T
R
I
L
T
V
G
V
Q
S
H
P
H
S
L
A
I
I
---
C
G
E
R
Q
-
L
S
Y
I
E
L
D
R
L
S
T
N
L
A
T
R
L
A
E
K
G
L
G
K
G
D
T
A
L
V
Q
L
P
N
V
A
E
F
Y
I
V
F
F
A
L
L
K
A
G
V
V
V
L
N
A
L
Y
S
H
R
Q
Y
E
L
N
A
F
I
K
Q
I
Q
P
K
L
L
I
G
S
R
Q
---
H
E
V
F
S
N
N
Q
F
I
D
S
L
H
D
V
N
L
S
P
E
I
I
-
L
M
L
N
H
--
Q
--
A
--
T
D
F
--
G
L
L
D
W
---
I
-
E
T
P
AE
T
F
V
D
F
S
S
T
P
A
D
E
V
A
F
F
Q
L
S
G
G
S
T
G
T
P
K
L
I
P
R
T
H
N
D
Y
D
-
Y
S
V
R
A
S
-
A
E
I
C
G
L
N
S
N
T
R
L
L
C
A
L
P
A
P
H
N
F
M
L
S
S
P
G
A
L
G
V
L
H
A
G
G
C
V
V
M
A
P
N
P
E
P
L
N
C
F
S
I
I
Q
R
H
Q
V
N
M
A
S
L
V
P
S
A
V
I
M
W
L
E
K
--
A
A
Q
--
Y
K
D
Q
I
Q
S
L
K
L
L
Q
V
G
G
A
S
F
P
E
S
L
A
R
Q
V
P
E
V
L
---
N
C
K
L
Q
Q
V
F
G
M
A
E
G
----
L
V
N
Y
T
R
-----
L
D
D
S
D
E
Q
I
F
T
T
Q
G
R
P
I
S
S
D
D
E
I
K
I
V
D
E
Q
Y
R
E
V
-
P
E
G
E
I
-
G
M
L
A
T
R
G
P
Y
T
F
C
G
Y
Y
Q
S
P
E
H
N
S
Q
V
F
D
E
D
N
Y
Y
Y
S
G
D
L
V
Q
R
T
P
D
G
N
L
R
V
V
G
R
I
K
D
------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
64.76
44%
-46
- C4 -
3O82
3
?
A:
[10-439]
----
F
V
R
W
S
P
E
R
A
Q
H
Y
R
N
K
G
Y
W
I
D
Q
P
L
T
R
I
L
T
V
G
V
Q
S
H
P
H
S
L
A
I
I
---
C
G
E
R
Q
-
L
S
Y
I
E
L
D
R
L
S
T
N
L
A
T
R
L
A
E
K
G
L
G
K
G
D
T
A
L
V
Q
L
P
N
V
A
E
F
Y
I
V
F
F
A
L
L
K
A
G
V
V
V
L
N
A
L
Y
S
H
R
Q
Y
E
L
N
A
F
I
K
Q
I
Q
P
K
L
L
I
G
S
R
Q
---
H
E
V
F
S
N
N
Q
F
I
D
S
L
H
D
V
N
L
S
P
E
I
I
-
L
M
L
N
H
--
Q
--
A
--
T
D
F
--
G
L
L
D
W
---
I
-
E
T
P
AE
T
F
V
D
F
S
S
T
P
A
D
E
V
A
F
F
Q
L
S
G
G
S
T
G
T
P
K
L
I
P
R
T
H
N
D
Y
D
-
Y
S
V
R
A
S
-
A
E
I
C
G
L
N
S
N
T
R
L
L
C
A
L
P
A
P
H
N
F
M
L
S
S
P
G
A
L
G
V
L
H
A
G
G
C
V
V
M
A
P
N
P
E
P
L
N
C
F
S
I
I
Q
R
H
Q
V
N
M
A
S
L
V
P
S
A
V
I
M
W
L
E
K
--
A
A
Q
--
Y
K
D
Q
I
Q
S
L
K
L
L
Q
V
G
G
A
S
F
P
E
S
L
A
R
Q
V
P
E
V
L
---
N
C
K
L
Q
Q
V
F
G
M
A
E
G
----
L
V
N
Y
T
R
-----
L
D
D
S
D
E
Q
I
F
T
T
Q
G
R
P
I
S
S
D
D
E
I
K
I
V
D
E
Q
Y
R
E
V
-
P
E
G
E
I
-
G
M
L
A
T
R
G
P
Y
T
F
C
G
Y
Y
Q
S
P
E
H
N
S
Q
V
F
D
E
D
N
Y
Y
Y
S
G
D
L
V
Q
R
T
P
D
G
N
L
R
V
V
G
R
I
K
-------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
64.66
44%
-49
- C4 -
3U17
5
?
B:
[10-440]
----
F
V
R
W
S
P
E
R
A
Q
H
Y
R
N
K
G
Y
W
I
D
Q
P
L
T
R
I
L
T
V
G
V
Q
S
H
P
H
S
L
A
I
I
---
C
G
E
R
Q
-
L
S
Y
I
E
L
D
R
L
S
T
N
L
A
T
R
L
A
E
K
G
L
G
K
G
D
T
A
L
V
Q
L
P
N
V
A
E
F
Y
I
V
F
F
A
L
L
K
A
G
V
V
V
L
N
A
L
Y
S
H
R
Q
Y
E
L
N
A
F
I
K
Q
I
Q
P
K
L
L
I
G
S
R
Q
---
H
E
V
F
S
N
N
Q
F
I
D
S
L
H
D
V
N
L
S
P
E
I
I
-
L
M
L
N
H
--
Q
--
A
--
T
D
F
--
G
L
L
D
W
---
I
-
E
T
P
AE
T
F
V
D
F
S
S
T
P
A
D
E
V
A
F
F
Q
L
S
G
G
S
T
G
T
P
K
L
I
P
R
T
H
N
D
Y
D
-
Y
S
V
R
A
S
-
A
E
I
C
G
L
N
S
N
T
R
L
L
C
A
L
P
A
P
H
N
F
M
L
S
S
P
G
A
L
G
V
L
H
A
G
G
C
V
V
M
A
P
N
P
E
P
L
N
C
F
S
I
I
Q
R
H
Q
V
N
M
A
S
L
V
P
S
A
V
I
M
W
L
E
K
--
A
A
Q
--
Y
K
D
Q
I
Q
S
L
K
L
L
Q
V
G
G
A
S
F
P
E
S
L
A
R
Q
V
P
E
V
L
---
N
C
K
L
Q
Q
V
F
G
M
A
E
G
----
L
V
N
Y
T
R
-----
L
D
D
S
D
E
Q
I
F
T
T
Q
G
R
P
I
S
S
D
D
E
I
K
I
V
D
E
Q
Y
R
E
V
-
P
E
G
E
I
-
G
M
L
A
T
R
G
P
Y
T
F
C
G
Y
Y
Q
S
P
E
H
N
S
Q
V
F
D
E
D
N
Y
Y
Y
S
G
D
L
V
Q
R
T
P
D
G
N
L
R
V
V
G
R
I
K
D
------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
64.48
44%
-47
- C4 -
3O83
6
?
B:
[10-440]
----
F
V
R
W
S
P
E
R
A
Q
H
Y
R
N
K
G
Y
W
I
D
Q
P
L
T
R
I
L
T
V
G
V
Q
S
H
P
H
S
L
A
I
I
---
C
G
E
R
Q
-
L
S
Y
I
E
L
D
R
L
S
T
N
L
A
T
R
L
A
E
K
G
L
G
K
G
D
T
A
L
V
Q
L
P
N
V
A
E
F
Y
I
V
F
F
A
L
L
K
A
G
V
V
V
L
N
A
L
Y
S
H
R
Q
Y
E
L
N
A
F
I
K
Q
I
Q
P
K
L
L
I
G
S
R
Q
---
H
E
V
F
S
N
N
Q
F
I
D
S
L
H
D
V
N
L
S
P
E
I
I
-
L
M
L
N
H
--
Q
--
A
--
T
D
F
--
G
L
L
D
W
---
I
-
E
T
P
AE
T
F
V
D
F
S
S
T
P
A
D
E
V
A
F
F
Q
L
S
G
G
S
T
G
T
P
K
L
I
P
R
T
H
N
D
Y
D
-
Y
S
V
R
A
S
-
A
E
I
C
G
L
N
S
N
T
R
L
L
C
A
L
P
A
P
H
N
F
M
L
S
S
P
G
A
L
G
V
L
H
A
G
G
C
V
V
M
A
P
N
P
E
P
L
N
C
F
S
I
I
Q
R
H
Q
V
N
M
A
S
L
V
P
S
A
V
I
M
W
L
E
K
--
A
A
Q
--
Y
K
D
Q
I
Q
S
L
K
L
L
Q
V
G
G
A
S
F
P
E
S
L
A
R
Q
V
P
E
V
L
---
N
C
K
L
Q
Q
V
F
G
M
A
E
G
----
L
V
N
Y
T
R
-----
L
D
D
S
D
E
Q
I
F
T
T
Q
G
R
P
I
S
S
D
D
E
I
K
I
V
D
E
Q
Y
R
E
V
-
P
E
G
E
I
-
G
M
L
A
T
R
G
P
Y
T
F
C
G
Y
Y
Q
S
P
E
H
N
S
Q
V
F
D
E
D
N
Y
Y
Y
S
G
D
L
V
Q
R
T
P
D
G
N
L
R
V
V
G
R
I
K
D
------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
64.34
44%
-48
- C4 -
3U16
6
?
A:
[10-439]
----
F
V
R
W
S
P
E
R
A
Q
H
Y
R
N
K
G
Y
W
I
D
Q
P
L
T
R
I
L
T
V
G
V
Q
S
H
P
H
S
L
A
I
I
---
C
G
E
R
Q
-
L
S
Y
I
E
L
D
R
L
S
T
N
L
A
T
R
L
A
E
K
G
L
G
K
G
D
T
A
L
V
Q
L
P
N
V
A
E
F
Y
I
V
F
F
A
L
L
K
A
G
V
V
V
L
N
A
L
Y
S
H
R
Q
Y
E
L
N
A
F
I
K
Q
I
Q
P
K
L
L
I
G
S
R
Q
---
H
E
V
F
S
N
N
Q
F
I
D
S
L
H
D
V
N
L
S
P
E
I
I
-
L
M
L
N
H
--
Q
--
A
--
T
D
F
--
G
L
L
D
W
---
I
-
E
T
P
AE
T
F
V
D
F
S
S
T
P
A
D
E
V
A
F
F
Q
L
S
G
--
T
G
T
P
K
L
I
P
R
T
H
N
D
Y
D
-
Y
S
V
R
A
S
-
A
E
I
C
G
L
N
S
N
T
R
L
L
C
A
L
P
A
P
H
N
F
M
L
S
S
P
G
A
L
G
V
L
H
A
G
G
C
V
V
M
A
P
N
P
E
P
L
N
C
F
S
I
I
Q
R
H
Q
V
N
M
A
S
L
V
P
S
A
V
I
M
W
L
E
K
--
A
A
Q
--
Y
K
D
Q
I
Q
S
L
K
L
L
Q
V
G
G
A
S
F
P
E
S
L
A
R
Q
V
P
E
V
L
---
N
C
K
L
Q
Q
V
F
G
M
A
E
G
----
L
V
N
Y
T
R
-----
L
D
D
S
D
E
Q
I
F
T
T
Q
G
R
P
I
S
S
D
D
E
I
K
I
V
D
E
Q
Y
R
E
V
-
P
E
G
E
I
-
G
M
L
A
T
R
G
P
Y
T
F
C
G
Y
Y
Q
S
P
E
H
N
S
Q
V
F
D
E
D
N
Y
Y
Y
S
G
D
L
V
Q
R
T
P
D
G
N
L
R
V
V
G
R
I
K
-------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
64.30
44%
-46
- C4 -
3U16
4
?
B:
[10-441]
----
F
V
R
W
S
P
E
R
A
Q
H
Y
R
N
K
G
Y
W
I
D
Q
P
L
T
R
I
L
T
V
G
V
Q
S
H
P
H
S
L
A
I
I
---
C
G
E
R
Q
-
L
S
Y
I
E
L
D
R
L
S
T
N
L
A
T
R
L
A
E
K
G
L
G
K
G
D
T
A
L
V
Q
L
P
N
V
A
E
F
Y
I
V
F
F
A
L
L
K
A
G
V
V
V
L
N
A
L
Y
S
H
R
Q
Y
E
L
N
A
F
I
K
Q
I
Q
P
K
L
L
I
G
S
R
Q
---
H
E
V
F
S
N
N
Q
F
I
D
S
L
H
D
V
N
L
S
P
E
I
I
-
L
M
L
N
H
--
Q
--
A
--
T
D
F
--
G
L
L
D
W
---
I
-
E
T
P
AE
T
F
V
D
F
S
S
T
P
A
D
E
V
A
F
F
Q
L
S
G
G
S
T
G
T
P
K
L
I
P
R
T
H
N
D
Y
D
-
Y
S
V
R
A
S
-
A
E
I
C
G
L
N
S
N
T
R
L
L
C
A
L
P
A
P
H
N
F
M
L
S
S
P
G
A
L
G
V
L
H
A
G
G
C
V
V
M
A
P
N
P
E
P
L
N
C
F
S
I
I
Q
R
H
Q
V
N
M
A
S
L
V
P
S
A
V
I
M
W
L
E
K
--
A
A
Q
--
Y
K
D
Q
I
Q
S
L
K
L
L
Q
V
G
G
A
S
F
P
E
S
L
A
R
Q
V
P
E
V
L
---
N
C
K
L
Q
Q
V
F
G
M
A
E
G
----
L
V
N
Y
T
R
-----
L
D
D
S
D
E
Q
I
F
T
T
Q
G
R
P
I
S
S
D
D
E
I
K
I
V
D
E
Q
Y
R
E
V
-
P
E
G
E
I
-
G
M
L
A
T
R
G
P
Y
T
F
C
G
Y
Y
Q
S
P
E
H
N
S
Q
V
F
D
E
D
N
Y
Y
Y
S
G
D
L
V
Q
R
T
P
D
G
N
L
R
V
V
G
R
I
K
D
Q
-----------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
64.22
44%
-47
- C4 -
3O83
6
?
A:
[10-439]
----
F
V
R
W
S
P
E
R
A
Q
H
Y
R
N
K
G
Y
W
I
D
Q
P
L
T
R
I
L
T
V
G
V
Q
S
H
P
H
S
L
A
I
I
---
C
G
E
R
Q
-
L
S
Y
I
E
L
D
R
L
S
T
N
L
A
T
R
L
A
E
K
G
L
G
K
G
D
T
A
L
V
Q
L
P
N
V
A
E
F
Y
I
V
F
F
A
L
L
K
A
G
V
V
V
L
N
A
L
Y
S
H
R
Q
Y
E
L
N
A
F
I
K
Q
I
Q
P
K
L
L
I
G
S
R
Q
---
H
E
V
F
S
N
N
Q
F
I
D
S
L
H
D
V
N
L
S
P
E
I
I
-
L
M
L
N
H
--
Q
--
A
--
T
D
F
--
G
L
L
D
W
---
I
-
E
T
P
AE
T
F
V
D
F
S
S
T
P
A
D
E
V
A
F
F
Q
L
S
G
G
--
G
T
P
K
L
I
P
R
T
H
N
D
Y
D
-
Y
S
V
R
A
S
-
A
E
I
C
G
L
N
S
N
T
R
L
L
C
A
L
P
A
P
H
N
F
M
L
S
S
P
G
A
L
G
V
L
H
A
G
G
C
V
V
M
A
P
N
P
E
P
L
N
C
F
S
I
I
Q
R
H
Q
V
N
M
A
S
L
V
P
S
A
V
I
M
W
L
E
K
--
A
A
Q
--
Y
K
D
Q
I
Q
S
L
K
L
L
Q
V
G
G
A
S
F
P
E
S
L
A
R
Q
V
P
E
V
L
---
N
C
K
L
Q
Q
V
F
G
M
A
E
G
----
L
V
N
Y
T
R
-----
L
D
D
S
D
E
Q
I
F
T
T
Q
G
R
P
I
S
S
D
D
E
I
K
I
V
D
E
Q
Y
R
E
V
-
P
E
G
E
I
-
G
M
L
A
T
R
G
P
Y
T
F
C
G
Y
Y
Q
S
P
E
H
N
S
Q
V
F
D
E
D
N
Y
Y
Y
S
G
D
L
V
Q
R
T
P
D
G
N
L
R
V
V
G
R
I
K
-------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
63.93
44%
-47
- C4 -
3O84
5
?
A:
[10-439]
----
F
V
R
W
S
P
E
R
A
Q
H
Y
R
N
K
G
Y
W
I
D
Q
P
L
T
R
I
L
T
V
G
V
Q
S
H
P
H
S
L
A
I
I
---
C
G
E
R
Q
-
L
S
Y
I
E
L
D
R
L
S
T
N
L
A
T
R
L
A
E
K
G
L
G
K
G
D
T
A
L
V
Q
L
P
N
V
A
E
F
Y
I
V
F
F
A
L
L
K
A
G
V
V
V
L
N
A
L
Y
S
H
R
Q
Y
E
L
N
A
F
I
K
Q
I
Q
P
K
L
L
I
G
S
R
Q
---
H
E
V
F
S
N
N
Q
F
I
D
S
L
H
D
V
N
L
S
P
E
I
I
-
L
M
L
N
H
--
Q
--
A
--
T
D
F
--
G
L
L
D
W
---
I
-
E
T
P
AE
T
F
V
D
F
S
S
T
P
A
D
E
V
A
F
F
Q
L
S
G
--
T
G
T
P
K
L
I
P
R
T
H
N
D
Y
D
-
Y
S
V
R
A
S
-
A
E
I
C
G
L
N
S
N
T
R
L
L
C
A
L
P
A
P
H
N
F
M
L
S
S
P
G
A
L
G
V
L
H
A
G
G
C
V
V
M
A
P
N
P
E
P
L
N
C
F
S
I
I
Q
R
H
Q
V
N
M
A
S
L
V
P
S
A
V
I
M
W
L
E
K
--
A
A
Q
--
Y
K
D
Q
I
Q
S
L
K
L
L
Q
V
G
G
A
S
F
P
E
S
L
A
R
Q
V
P
E
V
L
---
N
C
K
L
Q
Q
V
F
G
M
A
E
G
----
L
V
N
Y
T
R
-----
L
D
D
S
D
E
Q
I
F
T
T
Q
G
R
P
I
S
S
D
D
E
I
K
I
V
D
E
Q
Y
R
E
V
-
P
E
G
E
I
-
G
M
L
A
T
R
G
P
Y
T
F
C
G
Y
Y
Q
S
P
E
H
N
S
Q
V
F
D
E
D
N
Y
Y
Y
S
G
D
L
V
Q
R
T
P
D
G
N
L
R
V
V
G
R
I
K
-------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
63.75
44%
-48
- C4 -
3U17
6
?
A:
[10-439]
----
F
V
R
W
S
P
E
R
A
Q
H
Y
R
N
K
G
Y
W
I
D
Q
P
L
T
R
I
L
T
V
G
V
Q
S
H
P
H
S
L
A
I
I
---
C
G
E
R
Q
-
L
S
Y
I
E
L
D
R
L
S
T
N
L
A
T
R
L
A
E
K
G
L
G
K
G
D
T
A
L
V
Q
L
P
N
V
A
E
F
Y
I
V
F
F
A
L
L
K
A
G
V
V
V
L
N
A
L
Y
S
H
R
Q
Y
E
L
N
A
F
I
K
Q
I
Q
P
K
L
L
I
G
S
R
Q
---
H
E
V
F
S
N
N
Q
F
I
D
S
L
H
D
V
N
L
S
P
E
I
I
-
L
M
L
N
H
--
Q
--
A
--
T
D
F
--
G
L
L
D
W
---
I
-
E
T
P
AE
T
F
V
D
F
S
S
T
P
A
D
E
V
A
F
F
Q
L
S
G
--
T
G
T
P
K
L
I
P
R
T
H
N
D
Y
D
-
Y
S
V
R
A
S
-
A
E
I
C
G
L
N
S
N
T
R
L
L
C
A
L
P
A
P
H
N
F
M
L
S
S
P
G
A
L
G
V
L
H
A
G
G
C
V
V
M
A
P
N
P
E
P
L
N
C
F
S
I
I
Q
R
H
Q
V
N
M
A
S
L
V
P
S
A
V
I
M
W
L
E
K
--
A
A
Q
--
Y
K
D
Q
I
Q
S
L
K
L
L
Q
V
G
G
A
S
F
P
E
S
L
A
R
Q
V
P
E
V
L
---
N
C
K
L
Q
Q
V
F
G
M
A
E
G
----
L
V
N
Y
T
R
-----
L
D
D
S
D
E
Q
I
F
T
T
Q
G
R
P
I
S
S
D
D
E
I
K
I
V
D
E
Q
Y
R
E
V
-
P
E
G
E
I
-
G
M
L
A
T
R
G
P
Y
T
F
C
G
Y
Y
Q
S
P
E
H
N
S
Q
V
F
D
E
D
N
Y
Y
Y
S
G
D
L
V
Q
R
T
P
D
G
N
L
R
V
V
G
R
I
K
-------------------------------------------------------------------------------------------------------------
45
HHSearch
61.83
44%
-43
- C4 -
3O83
6
?
A:
[11-439]
-----
V
R
W
S
P
E
R
A
Q
H
Y
R
N
K
G
Y
W
I
D
Q
P
L
T
R
I
L
T
V
G
V
Q
S
H
P
H
S
L
A
I
I
---
C
G
E
R
Q
-
L
S
Y
I
E
L
D
R
L
S
T
N
L
A
T
R
L
A
E
K
G
L
G
K
G
D
T
A
L
V
Q
L
P
N
V
A
E
F
Y
I
V
F
F
A
L
L
K
A
G
V
V
V
L
N
A
L
Y
S
H
R
Q
Y
E
L
N
A
F
I
K
Q
I
Q
P
K
L
L
I
G
S
R
Q
---
H
E
V
F
S
N
N
Q
F
I
D
S
L
H
D
V
N
L
S
P
E
I
I
L
M
L
N
H
Q
--
A
--
T
DF
G
L
L
--
D
W
I
E
T
---
P
A
E
T
F
----
V
D
F
S
S
T
P
A
D
E
V
A
F
F
Q
L
S
G
G
--
G
T
P
K
L
I
P
R
T
H
N
D
Y
D
-
Y
S
V
R
A
S
-
A
E
I
C
G
L
N
S
N
T
R
L
L
C
A
L
P
A
P
H
N
F
M
L
S
S
P
G
A
L
G
V
L
H
A
G
G
C
V
V
M
A
P
N
P
E
P
L
N
C
F
S
I
I
Q
R
H
Q
V
N
M
A
S
L
V
P
S
A
V
I
M
W
L
E
K
--
A
A
Q
--
Y
K
D
Q
I
Q
S
L
K
L
L
Q
V
G
G
A
S
F
P
E
S
L
A
R
Q
V
P
E
V
L
---
N
C
K
L
Q
Q
V
F
G
M
A
E
G
----
L
V
N
Y
T
R
-----
L
D
D
S
D
E
Q
I
F
T
T
Q
G
R
P
I
S
S
D
D
E
I
K
I
V
D
E
Q
Y
R
E
V
-
P
E
G
E
I
-
G
M
L
A
T
R
G
P
Y
T
F
C
G
Y
Y
Q
S
P
E
H
N
S
Q
V
F
D
E
D
N
Y
Y
Y
S
G
D
L
V
Q
R
T
P
D
G
N
L
R
V
V
G
R
I
K
-------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
52.77
30%
9
- C4 -
1ULT
1
LCFCS_THET8
A:
[22-532]
----------------------------
D
F
L
E
R
A
A
A
L
F
G
R
K
E
V
V
S
R
L
H
T
G
E
V
H
R
T
T
Y
A
E
V
Y
Q
R
A
R
R
L
M
G
G
L
R
A
L
G
V
G
V
G
D
R
V
A
T
L
G
F
N
H
F
R
H
L
E
A
Y
F
A
V
P
G
M
G
A
V
L
H
T
A
N
P
R
L
S
P
K
E
I
A
Y
I
L
N
H
A
E
D
K
V
L
L
F
D
P
--------
N
L
L
P
L
V
E
A
I
R
G
E
L
K
T
V
Q
H
F
-
V
V
M
D
E
--
K
AP
E
--
G
Y
L
--
A
Y
E
E
A
LGE
E
-
A
D
P
----
V
R
V
P
E
R
A
A
C
G
M
A
Y
---
T
T
G
T
T
G
L
P
K
G
V
V
Y
S
H
R
A
L
V
L
H
S
L
A
A
S
L
V
D
G
T
A
L
S
E
K
D
V
V
L
P
V
V
P
M
F
H
V
N
A
W
C
L
P
-
Y
A
A
T
L
V
G
A
K
Q
V
L
P
G
P
R
L
D
P
A
S
L
V
E
L
F
D
G
E
G
V
T
F
T
A
G
V
P
T
V
W
L
A
L
A
D
Y
--
L
E
S
--
T
G
H
R
L
K
T
L
R
R
L
V
V
G
G
S
A
----
A
P
R
S
L
I
A
R
F
E
R
M
G
V
E
V
R
Q
G
Y
G
L
T
E
T
SPVV
V
Q
N
F
V
K
SHLES
L
S
E
E
E
K
L
T
L
K
A
K
T
G
L
P
I
P
L
V
R
L
R
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A
D
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E
G
R
P
V
P
K
D
G
K
A
L
G
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Q
L
K
G
P
W
I
T
G
G
Y
Y
G
N
E
E
A
T
R
S
A
L
T
P
D
G
F
F
R
T
G
D
I
A
V
W
D
E
E
G
Y
V
E
I
K
D
R
L
K
D
L
I
K
S
G
G
E
W
I
S
S
V
D
L
E
N
A
L
M
G
H
P
K
V
K
E
A
A
V
V
A
I
P
H
P
K
W
Q
E
R
P
L
A
V
V
V
P
R
G
E
K
P
T
P
E
E
L
N
E
H
L
L
K
A
G
F
A
K
W
Q
L
P
D
A
Y
V
F
A
E
E
I
P
R
T
S
A
G
K
F
L
K
R
A
L
R
E
------------