@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu32130: (2016-07-23 )
MENVFDYEDIQLIPAKCIVNSRSECDTSVRLGGHTFKLPVVPANMQTIIDEKLAISLAENGYFYVMHRFEPETRIDFIKDMNARGLFSSISVGVKDEEYEFVRQLAEENLTPEYVTIDIAHGHSNAVIEMIQHLKKHLPDSFVIAGNVGTPEAVRELENAGADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTHGDIAKSIRFGATMVMIGSLFAGHEESPGQTIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMHVAHKGSIKDTLIEMEQDLQSSISYAGGTKLNAIRNVDYVIVKNSIFNGDKY
Atome Classification :
(41 SA)
.........10........20........30..-.-.-.....40........50........60.......----------------.----70.--.-----------.-----------------------..---.-...----80-----------.--.-.-.-----------.------------------------------------------------------------------------------------------------.------------------------------------------------------------------------------------------------...90........100.......110.......120.......130.......140....--...150.......160.......170.......180.......190.......---200-.---.---.......210.......220.......230.......240...-....250..--.....---------260.--.-----.--.....---.-270.......280.......290.......300......-.310........320....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MENVFD
Y
E
D
I
Q
L
I
P
A
K
CIVNSRSECDT
S
V
R
-LG-
G
-
H
-
T
F
K
L
PVVPA
N
M
Q
T
I
I
D
E
K
L
A
I
S
LAEN
G
Y
F
Y
V
M
H
R----------------F----E-P--
E
-----------
T
-----------------------
R
I
---
D
-
F
I
K
----D------------M--N-A-R-----------G------------------------------------------------------------------------------------------------L------------------------------------------------------------------------------------------------
F
S
S
ISVGVKD
E
E
Y
E
F
V
R
Q
L
A
E
ENLTP
E
Y
V
T
I
D
I
AHGH
S
N
A
V
I
E
M
I
Q
H
L
K
K
HLPD
S
F
V
I
AG--NVG
T
P
E
A
V
R
E
L
E
NAGADATKVGIGPG
K
V
C
I
T
K
IKTGFGTGG
W
Q
L
A
A
L
R
W
C
A
K
A---A---S---K---
P
I
IADGGIRT
H
G
D
I
A
K
S
I
RFG
A
T
M
V
M
I
G
S
L
FAGHEESPGQ
T
I
E
-KD
G
K
L
Y
K
E
Y--FG
S
A
S
---------
E
--F--Q-----K--GEKKN---V-EG
K
K
M
H
V
A
HKGS
I
K
D
T
L
I
E
M
E
Q
D
L
Q
S
S
ISYAGGTK
L
N
A
I
-RN-V
D
Y
V
I
V
KNSIFNGDKY
1
PsiBlast_PDB
99.01
88%
-105
- C2 -
2A1Y
1
GUAC_BACAN
A:
[10-330]
M
G
N
V
F
D
Y
E
D
I
Q
L
I
P
A
K
C
I
V
N
S
R
S
E
C
D
T
T
V
T
-
L
G
-
K
-
H
-
K
F
K
L
P
V
V
P
A
N
M
Q
T
I
I
D
E
R
I
A
T
Y
L
A
E
N
N
Y
F
Y
I
M
H
R
----------------
F
----
Q
-
P
--
E
-----------
K
-----------------------
R
I
---
S
-
F
I
R
----
D
------------
M
--
Q
-
S
-
R
-----------
G
------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------
I
A
S
I
S
V
G
V
K
E
D
E
Y
E
F
V
Q
Q
L
A
A
E
H
L
T
P
E
Y
I
T
I
D
I
A
H
G
H
S
N
A
V
I
N
M
I
Q
H
I
K
K
H
L
P
E
S
F
V
I
A
G
--
N
V
G
T
P
E
A
V
R
E
L
E
N
A
G
A
D
A
T
K
V
G
I
G
P
G
K
V
C
I
T
K
I
K
T
G
F
G
T
G
G
W
Q
L
A
A
L
R
W
C
A
K
A
---
A
---
S
---
K
---
P
I
I
A
D
G
G
I
R
T
N
G
D
V
A
K
S
I
R
F
G
A
T
M
V
M
I
G
S
L
F
A
G
H
E
E
S
P
G
E
T
I
E
-
K
---
L
Y
K
E
Y
--
F
G
S
-----------------------------------------
F
V
E
H
K
G
S
L
E
D
T
L
I
E
M
E
Q
D
L
Q
S
S
I
S
Y
A
G
G
T
K
L
D
S
I
-
R
T
-
V
D
Y
V
V
V
K
N
S
I
F
-----
11
PsiBlast_PDB
64.49
34%
-26
- C2 -
4MYX
6
?
A:
[35-352]
----
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
-
S
E
-
S
-
L
-
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
----------------
N
MS
I
E
Q
-
Q
--
A
-----------
E
-----------------------
Q
V
---
D
-
K
V
K
--------------------
R
-
S
-
G
-----------
G
------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
--
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
---
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
-
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
V
G
A
M
E
K---------------------
K
L
---
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
-
R
------------------
96
PsiBlast_CBE
63.92
33%
-4
- C2 -
4QJ1
4
?
A:
[13-340]
----
L
T
F
E
D
I
L
L
V
P
N
Y
S
E
V
L
P
R
-
E
V
S
L
E
T
K
-
L
T
-
K
-
N
V
S
L
K
I
P
L
I
S
S
A
M
D
T
V
T
E
H
L
M
A
V
G
M
A
R
L
G
G
I
G
I
I
H
K
N---------------
M
----
D
-
M
--
E
-----------
S
-----------------------
Q
V
---
N
E
V
L
K
----
V
------------
K
--
N
-
S
-
G
-----------
G
------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------
R
V
G
A
A
I
G
V
N
--
E
I
E
R
A
K
L
L
V
E
A
G
V
--
D
V
I
V
L
D
S
A
H
G
H
S
L
N
I
I
R
T
L
K
E
I
K
S
K
M
-
N
I
D
V
I
V
G
--
N
V
V
T
E
E
A
T
K
E
L
I
E
N
G
A
D
G
I
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
--
P
Q
I
T
A
I
E
K
C
S
S
V
---
A
---
S
---
K
F
G
I
P
I
I
A
D
G
G
I
R
Y
S
G
D
I
G
K
A
L
A
V
G
A
S
S
V
M
I
G
S
I
L
A
G
T
E
E
S
P
G
E
K
E
L
-
I
G
D
T
V
Y
K
Y
Y
--
R
G
M
G
S
VGAMK-----------------------
N
KMV
P
-
E
G
I
E
G
R
V
K
Y
K
G
E
M
E
G
V
V
Y
Q
L
V
G
G
L
R
S
C
M
G
Y
L
G
S
A
S
I
E
E
L
W
K
K
-
S
S
Y
V
E
I
T
T
S
-------
95
PsiBlast_CBE
63.89
33%
-10
- C2 -
4QJ1
4
?
B:
[13-340]
----
L
T
F
E
D
I
L
L
V
P
N
Y
S
E
V
L
P
R
-
E
V
S
L
E
T
K
-
L
T
-
K
-
N
V
S
L
K
I
P
L
I
S
S
A
M
D
T
V
T
E
H
L
M
A
V
G
M
A
R
L
G
G
I
G
I
I
H
K
N---------------
M
----
D
-
M
--
E
-----------
S
-----------------------
Q
V
---
N
E
V
L
K
----
V
------------
K
--
N
-
S
-
G
-----------
G
------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------
R
V
G
A
A
I
G
V
N
--
E
I
E
R
A
K
L
L
V
E
A
G
V
--
D
V
I
V
L
D
S
A
H
G
H
S
L
N
I
I
R
T
L
K
E
I
K
S
K
M
-
N
I
D
V
I
V
G
--
N
V
V
T
E
E
A
T
K
E
L
I
E
N
G
A
D
G
I
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
--
P
Q
I
T
A
I
E
K
C
S
S
V
---
A
---
S
---
K
F
G
I
P
I
I
A
D
G
G
I
R
Y
S
G
D
I
G
K
A
L
A
V
G
A
S
S
V
M
I
G
S
I
L
A
G
T
E
E
S
P
G
E
K
E
L
-
I
G
D
T
V
Y
K
Y
Y
--
R
G
M
G
S
V
G
A
M
K
S----------------------
N
KMV
P
-
E
G
I
E
G
R
V
K
Y
K
G
E
M
E
G
V
V
Y
Q
L
V
G
G
L
R
S
C
M
G
Y
L
G
S
A
S
I
E
E
L
W
K
K
-
S
S
Y
V
E
I
T
T
S
-------
116
HHSearch
63.38
33%
-9
- C2 -
3R2G
-
?
A:
[6-328]
--
Q
A
I
T
F
D
D
V
L
L
V
P
S
Y
N
H
H
E
S
R
R
V
V
E
T
T
S
T
D
R
L
-
G
K
L
-
T
L
N
L
P
V
I
S
A
N
M
D
T
I
T
E
S
N
M
A
N
F
M
H
S
K
G
A
M
G
A
L
H
R
----------------
F
----
M
T
I
--
E
-----------
E
-----------------------
N
I
---
Q
-
E
F
K
----
K
---------------
C
-
K
-
G
-----------
P
------------------------------------------------------------------------------------------------
V
------------------------------------------------------------------------------------------------
F
V
S
V
G
C
T
--
E
N
E
L
Q
R
A
E
A
L
R
D
A
G
--
A
D
F
F
C
V
D
V
A
H
A
H
A
K
Y
V
G
K
T
L
K
S
L
R
Q
L
L
G
-
S
R
C
I
M
A
G
-
N
V
A
T
Y
A
G
A
D
Y
L
A
S
C
G
A
D
I
I
K
A
G
I
G
G
G
S
V
C
S
T
R
I
K
T
G
F
G
V
P
--
M
L
T
C
I
Q
D
C
S
R
----
A
---
D
---
R
---
S
I
V
A
D
G
G
I
K
T
S
G
D
I
V
K
A
L
A
F
G
A
D
F
V
M
I
G
G
M
L
A
G
S
A
P
T
P
G
E
V
F
Q
K
D
D
G
S
K
V
K
R
Y
--
R
G
M
A
S
R
E
-------
A
--
Q
--
E
A
F
L
GQ
M
--
H
E
W
K
T
---
A
-
E
G
V
A
T
E
V
P
F
K
E
N
P
D
G
I
I
A
D
I
I
G
G
L
R
S
G
L
T
Y
A
G
A
D
S
I
S
E
L
-
Q
R
K
L
N
Y
V
I
V
T
Q
A
G
R
-----
48
PsiBlast_CBE
63.16
34%
-24
- C2 -
4QM1
3
?
B:
[35-357]
----
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
-
S
E
-
S
-
L
-
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
----------------
N
MS
I
E
Q
-
Q
--
A
-----------
E
-----------------------
Q
V
---
D
-
K
V
K
--------------------
R
-
S
-
G
-----------
G
------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
--
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
---
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
-
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
V
G
A
M
E
K---------------------
K
L
---
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
-
R
------------------
93
PsiBlast_CBE
63.12
33%
-10
- C2 -
4QJ1
7
?
D:
[13-340]
----
L
T
F
E
D
I
L
L
V
P
N
Y
S
E
V
L
P
R
-
E
V
S
L
E
T
K
-
L
T
-
K
-
N
V
S
L
K
I
P
L
I
S
S
A
M
D
T
V
T
E
H
L
M
A
V
G
M
A
R
L
G
G
I
G
I
I
H
K
N---------------
M
----
D
-
M
--
E
-----------
S
-----------------------
Q
V
---
N
E
V
L
K
----
V
------------
K
--
N
-
S
-
G
-----------
G
------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------
R
V
G
A
A
I
G
V
N
--
E
I
E
R
A
K
L
L
V
E
A
G
V
--
D
V
I
V
L
D
S
A
H
G
H
S
L
N
I
I
R
T
L
K
E
I
K
S
K
M
-
N
I
D
V
I
V
G
--
N
V
V
T
E
E
A
T
K
E
L
I
E
N
G
A
D
G
I
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
--
P
Q
I
T
A
I
E
K
C
S
S
V
---
A
---
S
---
K
FGI
P
I
I
A
D
G
G
I
R
Y
S
G
D
I
G
K
A
L
A
V
G
A
S
S
V
M
I
G
S
I
L
A
G
T
E
E
S
P
G
E
K
E
L
-
I
G
D
T
V
Y
K
Y
Y
--
R
G
M
G
S
VGAMKS----------------------
N
KMV
P
-
E
G
I
E
G
R
V
K
Y
K
G
E
M
E
G
V
V
Y
Q
L
V
G
G
L
R
S
C
M
G
Y
L
G
S
A
S
I
E
E
L
W
K
K
-
S
S
Y
V
E
I
T
T
S
-------
113
HHSearch
63.08
33%
-10
- C2 -
4MYA
4
?
A:
[32-369]
-
K
E
G
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
-
P
R
E
V
S
V
K
T
V
-
L
S
-
E
S
L
-
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
----------------
N
----
M
S
I
--
E
-----------
Q
-----------------------
Q
A
---
E
-
Q
V
D
----
K
V
-----------
K
--
R
-
S
-
G
-----------
G
------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
--
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
--
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
--
Q
L
T
A
V
Y
D
C
A
T
E
---
A
R
K
H
G
---
I
---
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
-
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
---------
V
--
G
--
A
-----
M
E
K-
K
K
L
V
---
P
-
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
-
R
E
N
A
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
-
94
PsiBlast_CBE
63.01
33%
-10
- C2 -
4QJ1
4
?
C:
[13-340]
----
L
T
F
E
D
I
L
L
V
P
N
Y
S
E
V
L
P
R
-
E
V
S
L
E
T
K
-
L
T
-
K
-
N
V
S
L
K
I
P
L
I
S
S
A
M
D
T
V
T
E
H
L
M
A
V
G
M
A
R
L
G
G
I
G
I
I
H
K
N---------------
M
----
D
-
M
--
E
-----------
S
-----------------------
Q
V
---
N
E
V
L
K
----
V
------------
K
--
N
-
S
-
G
-----------
G
------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------
R
V
G
A
A
I
G
V
N
--
E
I
E
R
A
K
L
L
V
E
A
G
V
--
D
V
I
V
L
D
S
A
H
G
H
S
L
N
I
I
R
T
L
K
E
I
K
S
K
M
-
N
I
D
V
I
V
G
--
N
V
V
T
E
E
A
T
K
E
L
I
E
N
G
A
D
G
I
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
--
P
Q
I
T
A
I
E
K
C
S
S
V
---
A
---
S
---
K
F
G
I
P
I
I
A
D
G
G
I
R
Y
S
G
D
I
G
K
A
L
A
V
G
A
S
S
V
M
I
G
S
I
L
A
G
T
E
E
S
P
G
E
K
E
L
-
I
G
D
T
V
Y
K
Y
Y
--
R
G
M
G
S
V
G
A
M
K
S----------------------
N
KMV
P
-
E
G
I
E
G
R
V
K
Y
K
G
E
M
E
G
V
V
Y
Q
L
V
G
G
L
R
S
C
M
G
Y
L
G
S
A
S
I
E
E
L
W
K
K
-
S
S
Y
V
E
I
T
T
S
-------
98
PsiBlast_CBE
62.53
33%
-10
- C2 -
4IXH
5
IMDH_CRYPV
C:
[13-340]
----
L
T
F
E
D
I
L
L
V
P
N
Y
S
E
V
L
P
R
-
E
V
S
L
E
T
K
-
L
T
-
K
-
N
V
S
L
K
I
P
L
I
S
S
A
M
D
T
V
T
E
H
L
M
A
V
G
M
A
R
L
G
G
I
G
I
I
H
K
N---------------
M
----
D
-
M
--
E
-----------
S
-----------------------
Q
V
---
N
E
V
L
K
----
V
------------
K
--
N
-
S
-
G
-----------
G
------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------
R
V
G
A
A
I
G
V
N
--
E
I
E
R
A
K
L
L
V
E
A
G
V
--
D
V
I
V
L
D
S
A
H
G
H
S
L
N
I
I
R
T
L
K
E
I
K
S
K
M
-
N
I
D
V
I
V
G
--
N
V
V
T
E
E
A
T
K
E
L
I
E
N
G
A
D
G
I
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
--
P
Q
I
T
A
I
E
K
C
S
S
V
---
A
---
S
---
K
FGI
P
I
I
A
D
G
G
I
R
Y
S
G
D
I
G
K
A
L
A
V
G
A
S
S
V
M
I
G
S
I
L
A
G
T
E
E
S
P
G
E
K
E
L
-
I
G
D
T
V
Y
K
Y
Y
--
R
G
M
G
S
VGAMKSG----------------------MV-
P
-
E
G
I
E
G
R
V
K
Y
K
G
E
M
E
G
V
V
Y
Q
L
V
G
G
L
R
S
C
M
G
Y
L
G
S
A
S
I
E
E
L
W
K
K
-
S
S
Y
V
E
I
T
T
S
-------
69
PsiBlast_CBE
62.46
34%
-28
- C2 -
4MY1
3
?
F:
[35-352]
----
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
-
S
E
-
S
-
L
-
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
----------------
N
MS
I
E
Q
-
Q
--
A
-----------
E
-----------------------
Q
V
---
D
-
K
V
K
--------------------
R
-
S
-
G
-----------
G
------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
--
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
---
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
-
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
V
G
A
M
E
K
G---------------------
L
---
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
-
R
------------------
63
PsiBlast_CBE
62.45
34%
-27
- C2 -
4MY9
5
?
B:
[35-352]
----
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
-
S
E
-
S
-
L
-
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
----------------
N
MS
I
E
Q
-
Q
--
A
-----------
E
-----------------------
Q
V
---
D
-
K
V
K
--------------------
R
-
S
-
G
-----------
G
------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
--
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
---
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
-
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
V
G
A
M
E
K
G
SK-------------------
L
---
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
-
R
------------------
10
PsiBlast_PDB
62.31
34%
-20
- C2 -
4MY9
4
?
A:
[35-352]
----
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
-
S
E
-
S
-
L
-
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
----------------
N
MS
I
E
Q
-
Q
--
A
-----------
E
-----------------------
Q
V
---
D
-
K
V
K
--------------------
R
-
S
-
G
-----------
G
------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
--
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
---
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
-
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
V
G
A
M
E
K---------------------
K
L
---
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
-
R
------------------
73
PsiBlast_CBE
62.16
34%
-23
- C2 -
4MY1
3
?
B:
[35-352]
----
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
-
S
E
-
S
-
L
-
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
----------------
N
MS
I
E
Q
-
Q
--
A
-----------
E
-----------------------
Q
V
---
D
-
K
V
K
--------------------
R
-
S
-
G
-----------
G
------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
--
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
---
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
-
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
V
G
A
M
E
K
G
S--------------------
L
---
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
-
R
------------------
55
PsiBlast_CBE
62.07
34%
-24
- C2 -
4MYX
5
?
B:
[35-352]
----
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
-
S
E
-
S
-
L
-
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
----------------
N
MS
I
E
Q
-
Q
--
A
-----------
E
-----------------------
Q
V
---
D
-
K
V
K
--------------------
R
-
S
-
G
-----------
G
------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
--
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
---
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
-
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
VGAMEKGSK------------------
K
L
---
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
-
R
------------------
68
PsiBlast_CBE
62.06
34%
-21
- C2 -
4MY1
3
?
G:
[35-352]
----
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
-
S
E
-
S
-
L
-
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
----------------
N
MS
I
E
Q
-
Q
--
A
-----------
E
-----------------------
Q
V
---
D
-
K
V
K
--------------------
R
-
S
-
G
-----------
G
------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
--
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
---
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
-
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
VGAME-----------------------
L
---
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
-
R
------------------
46
PsiBlast_CBE
62.05
34%
-27
- C2 -
4QM1
3
?
D:
[35-356]
----
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
-
S
E
-
S
-
L
-
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
----------------
N
MSIE
Q
-
Q
--
A
-----------
E
-----------------------
Q
V
---
D
-
K
V
K
--------------------
R
-
S
-
G
-----------
G
------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
--
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
---
K
HGI
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
-
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
VGAME-----------------------
L
---
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
-
R
------------------
50
PsiBlast_CBE
61.97
34%
-26
- C2 -
4MYX
18
?
G:
[35-352]
----
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
-
S
E
-
S
-
L
-
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
----------------
N
MSIE
Q
-
Q
--
A
-----------
E
-----------------------
Q
V
---
D
-
K
V
K
--------------------
R
-
S
-
G
-----------
G
------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
--
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
---
K
HGI
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
-
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
VGAMEKGSK-----------------
K
K
L
---
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
-
R
------------------
91
PsiBlast_CBE
61.82
33%
-3
- C2 -
3KHJ
2
?
B:
[13-339]
----
L
T
F
E
D
I
L
L
V
P
N
Y
S
E
V
L
P
R
-
E
V
S
L
E
T
K
-
L
T
-
K
-
N
V
S
L
K
I
P
L
I
S
S
A
M
D
T
V
T
E
H
L
M
A
V
G
M
A
R
L
G
G
I
G
I
I
H
K
N---------------
M
----
D
-
M
--
E
-----------
S
-----------------------
Q
V
N
--
E
-
V
L
K
----
V
------------
K
--
N
-
S
-
G
-----------
G
------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------
R
V
G
A
A
I
G
V
N
--
E
I
E
R
A
K
L
L
V
E
A
G
V
--
D
V
I
V
L
D
S
A
H
G
H
S
L
N
I
I
R
T
L
K
E
I
K
S
K
M
-
N
I
D
V
I
V
G
--
N
V
V
T
E
E
A
T
K
E
L
I
E
N
G
A
D
G
I
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
--
P
Q
I
T
A
I
E
K
C
S
S
V
---
A
---
S
---
K
F
G
I
P
I
I
A
D
G
G
I
R
Y
S
G
D
I
G
K
A
L
A
V
G
A
S
S
V
M
I
G
S
I
L
A
G
T
E
E
S
P
G
E
K
E
L
-
I
G
D
T
V
Y
K
Y
Y
--
R
G
M
G
S
V
G
A
M
K
------------------------MV-
P
-
E
G
I
E
G
R
V
K
Y
K
G
E
M
E
G
V
V
Y
Q
L
V
G
G
L
R
S
C
M
G
Y
L
G
S
A
S
I
E
E
L
W
K
K
-
S
S
Y
V
E
I
T
T
--------
90
PsiBlast_CBE
61.82
33%
-10
- C2 -
3KHJ
2
?
C:
[13-340]
----
L
T
F
E
D
I
L
L
V
P
N
Y
S
E
V
L
P
R
-
E
V
S
L
E
T
K
-
L
T
-
K
-
N
V
S
L
K
I
P
L
I
S
S
A
M
D
T
V
T
E
H
L
M
A
V
G
M
A
R
L
G
G
I
G
I
I
H
K
N---------------
M
----
D
-
M
--
E
-----------
S
-----------------------
Q
V
N
--
E
-
V
L
K
----
V
------------
K
--
N
-
S
-
G
-----------
G
------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------
R
V
G
A
A
I
G
V
N
--
E
I
E
R
A
K
L
L
V
E
A
G
V
--
D
V
I
V
L
D
S
A
H
G
H
S
L
N
I
I
R
T
L
K
E
I
K
S
K
M
-
N
I
D
V
I
V
G
--
N
V
V
T
E
E
A
T
K
E
L
I
E
N
G
A
D
G
I
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
--
P
Q
I
T
A
I
E
K
C
S
S
V
---
A
---
S
---
K
F
G
I
P
I
I
A
D
G
G
I
R
Y
S
G
D
I
G
K
A
L
A
V
G
A
S
S
V
M
I
G
S
I
L
A
G
T
E
E
S
P
G
E
K
E
L
-
I
G
D
T
V
Y
K
Y
Y
--
R
---------------------------------------
G
I
E
G
R
V
K
Y
K
G
E
M
E
G
V
V
Y
Q
L
V
G
G
L
R
S
C
M
G
Y
L
G
S
A
S
I
E
E
L
W
K
K
-
S
S
Y
V
E
I
T
T
S
-------
56
PsiBlast_CBE
61.65
34%
-22
- C2 -
4MYA
3
?
B:
[35-352]
----
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
-
S
E
-
S
-
L
-
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
----------------
N
MS
I
E
Q
-
Q
--
A
-----------
E
-----------------------
Q
V
---
D
-
K
V
K
--------------------
R
-
S
-
G
-----------
G
------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
--
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
---
K
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
-
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
V
G
A
M
E
K---------------------
K
L
---
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
-
R
------------------
66
PsiBlast_CBE
61.52
34%
-24
- C2 -
4MY8
7
?
B:
[35-352]
----
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
-
S
E
-
S
-
L
-
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
----------------
N
MSIE
Q
-
Q
--
A
-----------
E
-----------------------
Q
V
---
D
-
K
V
K
--------------------
R
-
S
-
G
-----------
G
------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
--
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
---
K
HGI
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
-
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
VGAMEK----------------------
L
---
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
-
R
------------------
107
HHSearch
61.23
31%
-3
- C2 -
4ZQM
2
IMDH_MYCTU
A:
[45-387]
-
M
L
G
L
T
F
D
D
V
L
L
L
P
A
A
S
D
V
V
-
P
A
T
A
D
T
S
S
Q
-
L
T
-
K
K
I
-
R
L
K
V
P
L
V
S
S
A
M
D
T
V
T
E
S
R
M
A
I
A
M
A
R
A
G
G
M
G
V
L
H
R
----------------
N
----
L
P
V
--
A
-----------
E
-----------------------
Q
A
---
G
-
Q
V
E
----
M
------------
V
--
K
-
R
S
G
-----------
G
------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------
L
V
G
A
A
V
G
V
G
G
D
A
W
V
R
A
M
M
L
V
D
A
G
--
V
D
V
L
V
V
D
T
A
H
A
H
N
R
L
V
L
D
M
V
G
K
L
K
S
E
V
-
G
D
R
V
E
V
V
G
G
N
V
A
T
R
S
A
A
A
A
L
V
D
A
G
A
D
A
V
K
V
G
V
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
A
P
--
Q
I
T
A
I
L
E
A
V
A
A
---
C
R
P
A
G
---
V
---
P
V
I
A
D
G
G
L
Q
Y
S
G
D
I
A
K
A
L
A
A
G
A
S
T
A
M
L
G
S
L
L
A
G
T
A
E
A
P
G
E
L
I
F
-
V
N
G
K
Q
Y
K
S
Y
--
R
G
M
G
S
---------
L
--
G
AM------------
L
V
---
P
-
E
G
I
E
G
R
V
P
F
R
G
P
L
S
S
V
I
H
Q
L
T
G
G
L
R
A
A
M
G
Y
T
G
S
P
T
I
E
V
L
-
Q
Q
-
A
Q
F
V
R
I
T
P
A
G
L
-----
65
PsiBlast_CBE
60.62
34%
-26
- C2 -
4MY8
5
?
C:
[35-352]
----
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
-
S
E
-
S
-
L
-
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
----------------
N
MSIE
Q
-
Q
--
A
-----------
E
-----------------------
Q
V
---
D
-
K
V
K
--------------------
R
-
S
-
G
-----------
G
------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
--
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
---
K
HGI
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
-
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
VGAMEK---------------------
K
L
---
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
-
R
------------------
47
PsiBlast_CBE
60.57
34%
-23
- C2 -
4QM1
3
?
C:
[35-358]
----
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
R
E
V
S
V
K
T
V
L
-
S
E
-
S
-
L
-
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
----------------
N
MSIE
Q
-
Q
--
A
-----------
E
-----------------------
Q
V
---
D
-
K
V
K
--------------------
R
-
S
-
G
-----------
G
------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
--
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
--
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
--
P
Q
L
T
A
V
Y
D
C
A
T
E
---
A
---
R
---
K
HGI
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
-
Y
Q
G
R
Q
F
K
V
Y
--
R
G
M
G
S
VGAM----------------------------
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
-
R
------------------
81
PsiBlast_CBE
59.82
34%
-6
- C2 -
4IX2
2
?
B:
[14-334]
----
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
P
N
T
-
A
D
L
R
T
R
-
L
T
-
K
-
N
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
N---------------
M
----
S
-
I
--
E
-----------
Q
-----------------------
Q
A
---
A
-
Q
V
H
----
Q
------------
V
--
K
I
S
-
G
-----------
G
------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
--
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
--
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
--
P
Q
I
T
A
I
A
D
A
A
G
V
---
A
---
N
---
E
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
-
Y
Q
G
R
S
Y
K
A
Y
R
G
M
------------------------------------
P
-
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
-
R
T
-----------------
80
PsiBlast_CBE
59.78
34%
-13
- C2 -
4IX2
2
?
C:
[14-334]
----
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
P
N
T
-
A
D
L
R
T
R
-
L
T
-
K
-
N
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
N---------------
M
----
S
-
I
--
E
-----------
Q
-----------------------
Q
A
---
A
-
Q
V
H
----
Q
------------
V
--
K
I
S
-
G
-----------
G
------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
--
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
--
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
--
P
Q
I
T
A
I
A
D
A
A
G
V
---
A
---
N
---
E
YGI
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
-
Y
Q
G
R
S
Y
K
A
Y
RG
M
------------------------------------
P
-
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
-
R
T
-----------------
79
PsiBlast_CBE
59.49
34%
-8
- C2 -
4IX2
2
?
D:
[14-334]
----
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
P
N
T
-
A
D
L
R
T
R
-
L
T
-
K
-
N
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
N---------------
M
----
S
-
I
--
E
-----------
Q
-----------------------
Q
A
---
A
-
Q
V
H
----
Q
------------
V
--
K
I
S
-
G
-----------
G
------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
--
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
--
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
--
P
Q
I
T
A
I
A
D
A
A
G
V
---
A
---
N
---
E
YGI
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
-
Y
Q
G
R
S
Y
K
A
Y
RG
M
------------------------------------
P
-
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
-
R
T
-----------------
82
PsiBlast_CBE
59.09
34%
-2
- C2 -
4FO4
3
?
B:
[14-334]
----
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
P
N
T
-
A
D
L
R
T
R
-
L
T
-
K
-
N
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
N---------------
M
----
S
-
I
--
E
-----------
Q
-----------------------
Q
A
---
A
-
Q
V
H
----
Q
------------
V
--
K
I
S
-
G
-----------
G
------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
--
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
--
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
--
P
Q
I
T
A
I
A
D
A
A
G
V
---
A
---
N
---
E
YGI
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
-
Y
Q
G
R
S
Y
K
A
Y
RG
M
G
S
L
G
---------
A
--
M
--
S
----------
K
L
V
---
P
-
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
-
R
T
-----------------
18
PsiBlast_PDB
58.84
34%
-7
- C2 -
4QNE
3
?
A:
[14-334]
----
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
P
N
T
-
A
D
L
R
T
R
-
L
T
-
K
-
N
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
N---------------
M
----
S
-
I
--
E
-----------
Q
-----------------------
Q
A
---
A
-
Q
V
H
----
Q
------------
V
--
K
I
S
-
G
-----------
G
------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
--
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
--
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
--
P
Q
I
T
A
I
A
D
A
A
G
V
---
A
---
N
---
E
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
-
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
---------
A
--
M
--
S
-----------
L
V
---
P
-
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
-
R
T
-----------------
19
PsiBlast_PDB
58.45
34%
-3
- C2 -
4X3Z
3
?
A:
[14-334]
----
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
P
N
T
-
A
D
L
R
T
R
-
L
T
-
K
-
N
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
N---------------
M
----
S
-
I
--
E
-----------
Q
-----------------------
Q
A
---
A
-
Q
V
H
----
Q
------------
V
--
K
I
S
-
G
-----------
G
------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
--
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
--
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
--
P
Q
I
T
A
I
A
D
A
A
G
V
---
A
---
N
---
E
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
-
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
---------
A
--
M
--
S
-----------
L
V
---
P
-
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
-
R
T
-----------------
17
PsiBlast_PDB
57.83
34%
-13
- C2 -
4QQ3
3
?
A:
[14-334]
----
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
P
N
T
-
A
D
L
R
T
R
-
L
T
-
K
-
N
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
N---------------
M
----
S
-
I
--
E
-----------
Q
-----------------------
Q
A
---
A
-
Q
V
H
----
Q
------------
V
--
K
I
S
-
G
-----------
G
------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
--
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
--
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
--
P
Q
I
T
A
I
A
D
A
A
G
V
---
A
---
N
---
E
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
--------
G
R
S
Y
K
A
Y
R
G
M
G
------------------------------------------
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
-
R
T
-----------------
78
PsiBlast_CBE
57.04
34%
-3
- C2 -
4QNE
3
?
B:
[14-334]
----
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
P
N
T
-
A
D
L
R
T
R
-
L
T
-
K
-
N
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
N---------------
M
----
S
-
I
--
E
-----------
Q
-----------------------
Q
A
---
A
-
Q
V
H
----
Q
------------
V
--
K
I
S
-
G
-----------
G
------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
--
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
--
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
--
P
Q
I
T
A
I
A
D
A
A
G
V
---
A
---
N
---
E
YGI
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
-
Y
Q
G
R
S
Y
K
A
Y
RG
M
G
S
L
G
---------
A
--
M
--
S
-----------
L
V
---
P
-
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
-
R
T
-----------------
120
HHSearch
57.00
32%
-10
- C2 -
3USB
4
?
A:
[33-493]
--
E
G
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
-
P
R
E
V
S
V
K
T
V
-
L
S
E
S
-
L
-
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
----------------
N
----
M
-
S
I
-
E
Q
Q
A
--------
E
Q
V
D
K
V
K
R
SESGVIS
D
P
F
F
L
T
PEH
Q
V
---
Y
-
D
A
E
H
L
M
G
K
------------
Y
RI
S
-
G
-
V
-----------
P
------------------------------------------------------------------------------------------------
V
V
NNLDERKLV
G
I
I
T
N
R
D
M
R
F
IQDYSIKISDVMTK
E
Q
L
I
T
A
P
VGTT
L
S
E
A
E
K
I
L
Q
K
YKIE
K
L
P
L
V
D
NNGVLQ
G
L
I
T
I
K
D
I
E
K
V
I
E
F
PN
S
A
K
D
KQG
R
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
--
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
S
L
N
I
I
A
G
--
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
--
Q
L
T
A
V
Y
D
C
A
T
E
---
A
R
K
H
G
---
I
---
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
-
Y
Q
G
R
Q
F
K
V
------------------------------------------------
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
E
F
L
-
R
E
N
A
Q
F
I
R
M
S
G
A
G
L
L
----
77
PsiBlast_CBE
57.00
34%
-1
- C2 -
4X3Z
3
?
B:
[14-334]
----
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
P
N
T
-
A
D
L
R
T
R
-
L
T
-
K
-
N
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
N---------------
M
----
S
-
I
--
E
-----------
Q
-----------------------
Q
A
---
A
-
Q
V
H
----
Q
------------
V
--
K
I
S
-
G
-----------
G
------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
--
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
--
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
--
P
Q
I
T
A
I
A
D
A
A
G
V
---
A
---
N
---
E
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
-
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
---------
A
--
M
--
S
----------
K
L
V
---
P
-
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
-
R
T
-----------------
122
HHSearch
55.56
35%
16
- C2 -
1ZFJ
1
IMDH_STRPY
A:
[10-476]
--
K
G
Y
T
F
D
D
V
L
L
I
P
A
E
S
H
V
L
-
P
N
E
V
D
L
K
T
K
-
L
A
D
N
-
L
-
T
L
N
I
P
I
I
T
A
A
M
D
T
V
T
G
S
K
M
A
I
A
I
A
R
A
G
G
L
G
V
I
H
K
----------------
N
----
M
-
S
I
T
E
Q
A
E
E
V
R
K
V
K
R
S
E
NGVIID
P
F
F
L
T
PEH---------
K
V
---
S
-
E
A
E
E
L
M
Q
R
------------
Y
RI
S
-
G
-
V
-----------
P
I
V
ETLANRKLV
G
I
I
T
N
R
D
M
R
F
ISDYNAPISEHMTSEH
L
V
T
A
A
VGTD
L
E
T
A
E
R
I
L
H
E
H
RIE
K
L
P
L
V
D
NSGRLS
G
L
I
T
I
K
D
I
E
K
V
I
E
F
PHAAKDEFG
R
L
------------------------------------------------------------------------------------------------
L
V
A
A
A
V
G
V
T
S
D
T
F
E
R
A
E
A
L
F
E
A
G
--
A
D
A
I
V
I
D
T
A
H
G
H
S
A
G
V
L
R
K
I
A
E
I
R
A
H
F
P
N
R
T
L
I
A
G
--
N
I
A
T
A
E
G
A
R
A
L
Y
D
A
G
V
D
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
--
Q
V
T
A
I
Y
D
A
A
A
V
---
A
R
E
Y
G
---
K
---
T
I
I
A
D
G
G
I
K
Y
S
G
D
I
V
K
A
L
A
A
G
G
N
A
V
M
L
G
S
M
F
A
G
T
D
E
A
P
G
E
T
E
I
-
Y
Q
G
R
K
Y
K
T
Y
--
R
G
M
G
S
---------
I
AA
M
--
K
-----
K
---
N
K
L
V
---
P
-
E
G
I
E
G
R
V
A
Y
K
G
A
A
S
D
I
V
F
Q
M
L
G
G
I
R
S
G
M
G
Y
V
G
A
G
D
I
Q
E
L
-
H
E
N
A
Q
F
V
E
M
S
G
A
G
L
I
E
S
H
-
108
HHSearch
55.41
34%
12
- C2 -
4X3Z
4
?
A:
[11-350]
-
K
E
A
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
-
P
N
T
A
D
L
R
T
R
-
L
T
K
N
-
I
-
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
----------------
N
M---
S
-
I
--
E
Q
Q
A
--------
A
-----------------------
Q
V
---
H
-
Q
V
K
----
I
------------
S
--
G
-
G
-
L
-----------
R
------------------------------------------------------------------------------------------------
V
------------------------------------------------------------------------------------------------
G
A
A
V
G
A
A
--
P
G
N
E
E
R
V
K
A
L
V
E
A
G
--
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
--
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
--
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
Y
---
G
---
I
---
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
-
Y
Q
G
R
S
Y
K
A
Y
--
R
G
M
G
S
LG-------
A
--
M
--
S
-----------
L
V
---
P
-
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
-
R
T
K
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
-
114
HHSearch
54.26
34%
6
- C2 -
4R7J
8
?
A:
[7-367]
V
K
R
A
L
T
F
E
D
V
L
L
R
P
G
Y
S
E
V
L
-
P
K
E
V
K
I
H
T
K
-
L
T
K
N
-
I
-
T
L
N
M
P
L
I
S
A
A
M
D
T
V
T
E
H
R
A
A
I
M
M
A
R
L
G
G
L
G
V
I
H
K
----------------
N
----
M
D
I
--
A
S
Q
V
--------
R
-----------------------
E
V
---
K
-
R
V
K
----
K
SEKKRKEYPD
A
N
K
--
D
-
N
-
F
-----------
G
R
L
R
---------------------------------------------------------------------------------------------
V
------------------------------------------------------------------------------------------------
G
A
A
I
--
G
V
--
G
Q
M
D
R
V
D
A
L
V
E
A
G
--
V
D
V
V
V
L
D
S
A
H
G
H
S
K
G
I
I
D
T
V
K
A
I
K
A
K
Y
P
N
L
D
L
I
A
G
--
N
I
A
T
A
A
A
A
K
A
L
C
E
A
G
V
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
S
G
V
G
V
P
--
Q
I
S
A
I
D
E
C
V
E
E
---
A
N
K
F
G
---
V
---
P
V
I
A
D
G
G
I
K
Y
S
G
D
I
A
K
A
L
A
V
G
A
S
S
V
M
I
G
S
L
L
A
G
T
D
E
S
P
G
E
L
F
T
-
Y
Q
G
R
Q
Y
K
S
Y
--
R
G
M
G
S
---------
L
--
G
--
A
-----
M
QK---
L
V
---
P
-
E
G
I
E
G
R
V
P
Y
V
G
S
I
R
S
V
V
H
Q
L
L
G
G
L
R
S
S
M
G
Y
V
G
A
K
D
I
E
D
F
-
Q
K
R
A
E
F
V
E
I
T
T
A
G
L
K
E
S
H
-
126
HHSearch
54.18
35%
-19
* C2 *
5AHN
2
?
A:
[8-467]
---
A
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
L
-
P
K
D
V
S
L
K
T
R
-
L
T
R
G
-
I
-
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
----------------
N
----
M
G
I
--
E
Q
Q
A
A
E
V
-----
R
-----------------------
K
V
K
K
H------------------------------TYPL
A
S
K
D
EQG
R
------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------
R
V
G
A
A
V
G
T
G
A
D
T
G
E
R
V
A
A
L
V
A
A
G
--
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
D
V
Q
V
I
G
G
--
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
--
Q
I
S
A
I
A
N
V
A
A
A
---
L
---
E
GTG
V
---
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
-----------------------------------------------------------------
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
Q
Q
M
-
R
T
Q
P
Q
F
V
R
I
T
G
A
-------
84
PsiBlast_CBE
52.66
33%
14
- C2 -
4FEZ
6
?
A:
[14-356]
----
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
P
N
T
-
A
D
L
R
T
R
-
L
T
-
K
-
N
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
NMS
I
E
Q
Q
A
A
Q
V
H
Q
V
K
I
F
----
E
S---------------------------------------
K
P
---
N
-
A
C
K
----
D
------------
E
--
Q
-
G
-
R
------------------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
--
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
--
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
--
P
Q
I
T
A
I
A
D
A
A
G
V
---
A
---
N
---
E
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
-
Y
Q
G
R
S
Y
K
A
Y
R----------------------------------------------
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
-
R
T
-----------------
83
PsiBlast_CBE
51.75
33%
20
- C2 -
4FEZ
5
?
B:
[14-356]
----
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
P
N
T
-
A
D
L
R
T
R
-
L
T
-
K
-
N
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
NMS
I
E
Q
Q
A
A
Q
V
H
Q
V
K
I
F
----
E
S---------------------------------------
K
P
---
N
-
A
C
K
----
D
------------
E
--
Q
-
G
-
R
------------------------------------------------------------------------------------------------------------
L
------------------------------------------------------------------------------------------------
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
--
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
H
L
E
I
I
G
G
--
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
--
P
Q
I
T
A
I
A
D
A
A
G
V
---
A
---
N
---
E
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
-
Y
Q
G
R
S
Y
K
A
Y
---------------------------------------------
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
E
D
L
-
R
T
-----------------