@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu32370: (2016-07-24 )
MKEKLRLYHTNDLHSHFENWPKIVDYIEQKRKEHQSDGEETLVFDIGDHLDRFQFVTEATFGKANVDLLNRLHIDGAAIGNNEGITLPHEELAALYDHAEFPVIVSNLFDKNGNRPSWAVPYHIKSLKNGMSIAFLGVTVPYYPVYDKLGWTVTDALESIKETILEVKGQADIIVLLSHLGILDDQAVAEAVPEIDVILESHTHHLLEDGQVVNGVLLASAEKYGHYVGCVEITVDSVQRSINSKTASVQNMAEWTGESAETKAFLNEKEREAEEKLSDAVAELAQDAEVKWFEESELPLLLAYALKEWCETDISMVNSGVILGPLKAGPVTKLDLHRICPHPINPVAVRLTGEELKETIVHAASEQMEQLRIKGLGFRGEVMGKMVYAGVEVETKRLDDGITHVTRITLNGEDIEKHKQYSVAVLDMFTLGKLFPLIRDAAEKEYFMPEFLRDLLAWKLAQ
Atome Classification :
(20 SA)
.........10......----.---------------.-----------------20-----------......-------------...30------.......-----..40........50........-----60.......--.70........80........90.-.......100.......110.---.--..--....120.......130.......140------..-----....-----..----.150..--.....160......--.-170........180---------------..----------.-------------.----------------...190..--......200.....----..------------210----------------...-------------..-------------....220.......230...-....-240...--....---250--.----------..----------....260.-------......270.......280.......290---.----.......--.300....---..----------.----------310-.--........320..--..---.---..-330.......340..-.....350.......360.......370-.--.......380---.......-390.......400.......410------.----........420.......430..-.....440.......450.......460
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
E
K
L
R
L
Y
HT
N
D
L
H
S
H
F
----
E
---------------
N
-----------------
W
------------
P
K
I
V
D
Y
-------------
I
E
Q
K
-------
R
K
E
HQSD-----GE
E
T
L
V
F
DIGD
H
L
D
R
F
Q
F
V
T
EA-----TFGK
A
N
V
D
L
--
L
N
RLHID
G
A
AIGNNEGITL
P
H
E
E
L
-
A
A
L
YDHAE
F
P
V
I
V
S
N
L
F
D-KN---G--NR--PS
W
A
V
P
Y
H
I
K
S
L
KNG
M
S
I
A
F
L
G
VTV--------PY-----YP
V
Y
-----
D
K----LG
W
T
V
T
--
D
A
L
E
S
I
K
E
T
I
L
EVK--G-QA-DI
I
V
L
L
S
H
LGI---------------LD----------
D
-------------
Q
----------------
A
V
A
E
A-VP--
E
I
D
V
I
L
E
SH
T
H
H
L
L----ED------------G------------------
Q
V
V
-------------
N
G
-------------
V
L
L
ASAEKYG
H
Y
V
G
C
V
E
I
T
V
-
D
S
V
Q
-
R
S
INSK--
T
A
S
V
---
Q
N
M
--
A
----------
E
W----------TGES
A
E
T
K
-------
A
F
L
N
E
K
E
R
E
A
E
E
K
L
S
D
A
V
A
E
L
A
Q
DAE
V
-----
K
----
W
F
EESEL--
P
L
L
L
A
Y
A
L
---
K
E
----------
W
----------
C
---
E
--
T
D
I
S
M
VNS
G
V
I
L
G--PL---K---AG-PVTKL
D
L
H
R
ICPHPI-N
P
V
A
V
R
L
T
G
E
E
L
K
E
T
I
V
H
A
A
S
E
Q
M
E
Q
L
--
R
--IKGLG
F
R
G
E
V
---
M
G
K
M
V
YA-G
V
E
V
E
T
K
RLDDGI
T
H
V
T
R
I
T
L--------N----
G
E
D
I
E
K
H
KQY
S
V
A
V
L
D
M
F
T
L
G
K
L
-
F
P
L
I
R
D
A
A
EKEYF
M
P
E
F
L
R
D
L
L
A
W
KLAQ
33
HHSearch
78.88
24%
29
- C2 -
3IVE
5
?
A:
[4-483]
-
A
K
D
V
T
I
I
Y
T
N
D
L
H
A
H
V
----
E
---------------
P
Y
K
V
PWIADGKRDIGG--
W
------------
A
N
I
T
T
L
-------------
V
K
Q
E
-------
K
A
K
N
---------
K
A
T
W
F
F
D
A
G
D
Y
F
T
G
P
Y
-
I
S
S
L
-----
T
K
G
K
A
I
I
D
I
--
M
N
T
M
P
F
D
A
V
T
I
G
N
H
E
F
D
H
-
G
W
D
N
T
-
L
L
Q
L
S
Q
A
K
F
P
I
V
Q
G
N
I
F
Y
Q
N
S
---
S
--
K
S
---
F
W
D
K
P
Y
T
I
I
E
-
K
D
G
V
K
I
G
V
I
G
L
H
G
--------
V
F
-----
A
F
N
D
TVSAA
T
R
----
V
G
I
E
A
R
--
D
E
I
K
W
L
Q
R
Y
I
D
E
L
K
--
G
-
K
V
-
D
L
T
V
A
L
I
H
E
G
V
---------------
P
A
----------
R
QSSMD
V
R
R
A
L
D
K
D
I
----------------
Q
T
A
S
Q
-
V
K
--
G
L
D
I
L
I
T
G
H
A
H
V
G
T
----
P
E
------------
P
------------------
I
K
V
-------------
G
N
-------------
T
L
I
L
S
T
D
S
G
G
I
D
V
G
K
L
V
L
D
Y
-
K
E
K
P
-
H
N
F
T
V
K
--
N
F
E
L
---
K
T
I
Y
A
D
----------
E
W
----------
K
-
P
D
Q
Q
T
K
-------
Q
V
I
D
G
W
N
K
K
L
D
E
V
V
Q
Q
T
V
A
Q
S
P
V
E
L
K
R
-----
A
----
Y
G
E
S
A
S
L
--
G
N
L
A
A
D
A
L
---
L
A
----------
A
----------
A
---
G
KN
T
Q
L
A
L
T
N
S
G
G
I
R
N
--
E
I
---
P
---
A
G
-
A
I
T
M
G
G
V
I
S
T
F
P
F
P
N
-
E
L
V
T
M
E
L
T
G
K
Q
L
R
S
L
M
E
H
G
A
S
L
S
------------
N
G
V
L
----------
Q
V
S
K
G
L
E
M
K
Y
D
S
S
K
P
V
G
Q
R
V
I
T
L
T
L
--------
N
----
G
K
P
I
E
D
A
T
V
Y
H
I
A
T
Q
S
F
L
A
D
G
G
D
G
F
T
A
F
T
E
G
K
A
R
N
I
T
G
G
Y
Y
V
Y
H
A
V
V
D
Y
F
K
A
1
PsiBlast_PDB
74.27
23%
24
- C2 -
3IVD
4
?
A:
[3-452]
L
A
K
D
V
T
I
I
Y
T
N
D
L
H
A
H
V
----
E
P
Y
K
V
PWIADGKRDIG
G
-----------------
W
------------
A
N
I
T
T
L
-------------
V
K
Q
E
-------
K
A
K
N
K
A
---------
T
W
F
F
D
A
G
D
Y
F
T
G
-
P
Y
I
S
S
L
-----
T
K
G
K
A
I
I
D
I
--
M
N
T
M
P
F
D
A
V
T
I
G
N
H
E
F
D
H
G
W
D
N
T
L
-
L
Q
L
-
S
Q
A
K
F
P
I
V
Q
G
N
I
F
Y
-
Q
N
---
S
--
S
K
--
S
F
W
D
K
P
Y
T
I
I
E
-
K
D
G
V
K
I
G
V
I
G
L
H
G
--------
V
F
A
F
N
D
T
V
S
A
A
-----
T
R
----
V
G
I
E
A
R
--
D
E
I
K
W
L
Q
R
Y
I
D
E
L
K
--
G
-
K
V
-
D
L
T
V
A
L
I
H
E
G
V
PARQSSMGGTD
V
R
R
A
L
D
K
---------
D
-------------
I
----------------
Q
T
A
S
Q
-
V
K
--
G
L
D
I
L
I
T
G
H
A
H
V
G
T
----
P
E
------------
P
------------------
I
K
V
-------------
G
N
-------------
T
L
I
L
S
T
D
S
G
G
I
D
V
G
K
L
V
L
D
Y
-
K
E
K
P
-
H
N
F
T
V
K
--
N
F
E
L
---
K
T
I
--
Y
AD--------
E
W
----------
K
P
D
Q
-
Q
T
K
-------
Q
V
I
D
G
W
N
K
K
L
D
E
V
V
Q
Q
T
V
A
Q
S
P
V
E
L
K
R
-----
A
----
Y
G
E
S
A
S
L
G
N
L
A
A
D
A
L
L
A
---
A
A
----------
G
----------
K
---
N
--
T
Q
L
A
L
T
N
S
G
G
I
R
N
--
E
I
---
P
---
A
G
-
A
I
T
M
G
G
V
I
S
T
F
P
F
P
N
-
E
L
V
T
M
E
L
T
G
K
Q
L
R
S
L
M
E
H
G
A
S
L
S
N
G
V
L
--
Q
-------------------
V
S
K
-
G
L
E
M
K
Y
D
S
S
K
P
V
G
Q
R
V
I
T
L
T
L
--------
N
----
G
K
P
I
E
D
A
T
V
Y
H
I
A
T
Q
S
F
L
A
D
G
-------------------------------
32
HHSearch
74.03
22%
5
- C2 -
2Z1A
4
?
A:
[28-516]
--
F
T
L
T
L
V
H
T
N
D
T
H
A
H
L
----
E
---------------
P
V
E
L
T
L
SG
E
K
T
P
V
G
G---
V
------------
A
R
R
V
A
L
-------------
F
D
R
V
-------
W
A
R
A
---------
K
N
P
L
F
L
D
A
G
D
V
F
Q
G
T
L
-
Y
F
N
Q
-----
Y
R
G
L
A
D
R
Y
F
--
M
H
R
L
R
Y
R
A
M
A
L
G
N
H
E
F
D
L
-
G
P
G
P
L
-
A
D
F
L
K
G
A
R
F
K
V
V
S
A
N
V
D
A
S
R
E
---
P
--
R
L
--
K
G
L
F
A
P
Y
A
V
V
V
-
V
G
G
E
R
V
G
I
I
G
L
T
T
--------
P
D
-----
T
R
E
I
S----
N
P
G---
P
T
V
A
F
L
--
D
P
Y
E
S
A
Q
K
A
V
Y
E
L
L
--
A
K
G
V
-
N
K
I
V
V
L
S
H
L
G
Y
---------------
G
E
----------
D
-------------
L
----------------
K
L
A
R
R
-
L
V
--
G
V
Q
V
I
V
G
G
H
S
H
T
L
L
----
G
S
------------
F
PHKELSPAGPY
P
T
V
V
K
N
-
P
E
G
-------------
K
D
-------------
V
L
V
V
Q
A
W
E
W
G
K
V
V
G
L
L
E
V
T
F
-
D
A
K
G
--
E
L
L
A
Y
--
K
G
E
A
---
L
L
M
--
T
PE--------
A
A
----------
P
-
E
D
F
F
A
K
-------
E
A
L
L
A
Y
A
Q
P
V
M
A
L
M
Q
Q
V
I
A
E
A
K
V
D
L
V
G
-----
E
RAVV
R
R
R
E
S
N
L
--
G
N
L
I
T
D
G
M
---
L
W
----------
K
----------
T
R
NA
G
--
T
Q
I
A
L
Q
N
G
G
G
I
R
A
--
S
I
---
P
---
K
G
-
P
I
T
V
G
K
V
Y
E
V
L
P
F
G
N
-
T
L
V
V
M
D
L
K
G
K
E
I
L
A
A
L
E
N
G
V
S
Q
W
E
N
--------
T
A
G
R
F
L
----------
Q
V
S
-
G
L
R
Y
A
F
D
L
S
R
P
A
G
S
R
V
V
R
V
E
V
--------
K
T
EKG
Y
V
P
L
D
L
E
A
T
Y
R
V
V
V
N
N
F
I
A
N
G
G
D
G
F
T
V
L
K
E
A
Q
G
Y
R
V
D
T
G
F
S
D
A
E
S
F
M
D
Y
L
K
E
5
PsiBlast_PDB
72.05
22%
28
- C2 -
1OI8
4
USHA_ECOLI
A:
[8-477]
---
K
I
T
V
L
H
T
N
D
H
H
G
H
F
--------------------------------------
W
RNEYGEYG
L
A
A
Q
K
T
L
V
D
G
-------------
I
----------
R
K
E
V
A
A
E
-----
G
G
S
V
L
L
L
S
G
G
D
I
---
N
T
G
V
C
E
S
-----
D
L
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
-
F
D
N
P
L
T
V
L
-
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
-
K
S
T--
G
--
E
R
LF
K
P
W
A
L
-
F
K
R
Q
D
L
K
----
I
A
V
I
G
L
T
T
DDTAKIGN
P
E
-----
Y
F
T
D
-----
I
E
----
F
R
K
P
A
D
--
E
A
K
L
V
I
Q
E
--
L
Q
Q
T
--
E
-
K
P
-
D
I
I
I
A
A
T
H
M
G
H
---------------
Y
D
NGEHGSNAPG
D
-------------
V
----------------
E
M
A
R
A
-
L
P
AG
S
L
A
M
I
V
G
G
H
S
Q
D
P
V
CMAA
E
N
------------
K
------------------
K
Q
V
DYVPG
T
P
C
K
P
D
Q
Q
N
G
-------------
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
-
R
N
G
E
M
K
M
V
N
Y
Q
L
I
P
V
N
L
---
K
K
K
--
V
----------
T
W
EDG
K
S
E
R
V
L
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
R
L
E
G
D
R
D
K
-----
V
----
R
F
V
Q
T
N
M
--
G
R
L
I
L
A
A
Q
---
M
D
----------
R
----------
T
---
G
--
A
D
F
A
V
M
S
G
G
G
I
R
D
--
S
I
---
E
---
A
G
-
D
I
S
Y
K
N
V
C
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
-----
Q
M
--
K
--
P
D
S
G
A
Y
P
----------
Q
F
A
-
N
V
S
F
V
A
K
---
D
G
--
K
L
N
D
L
K
I
--------
K
----
G
E
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
-------------------------------
13
PsiBlast_PDB
71.60
22%
33
- C2 -
1OIE
1
USHA_ECOLI
A:
[8-477]
---
K
I
T
V
L
H
T
N
D
H
H
G
H
F
--------------------------------------
W
RNEYGEYG
L
A
A
Q
K
T
L
V
D
G
-------------
I
----------
R
K
E
V
A
A
E
-----
G
G
S
V
L
L
L
S
G
G
D
---
I
N
T
G
V
P
E
S
-----
D
L
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
-
F
D
N
P
L
T
V
L
-
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
-
K
S
T--
G
--
E
R
LF
K
P
W
A
L
-
F
K
R
Q
D
L
K
----
I
A
V
I
G
L
T
T
DDTAKIGN
P
E
-----
Y
F
T
D
-----
I
E
----
F
R
K
P
A
D
--
E
A
K
L
V
I
Q
E
--
L
Q
Q
T
--
E
-
K
P
-
D
I
I
I
A
A
T
H
M
G
H
---------------
Y
D
NGEHGCNAPG
D
-------------
V
----------------
E
M
A
R
A
-
L
P
AG
S
L
A
M
I
V
G
G
H
S
Q
D
P
V
CMAA
E
N
------------
K
------------------
K
Q
V
DYVPG
T
P
C
K
P
D
Q
Q
N
G
-------------
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
-
R
N
G
E
M
K
M
V
N
Y
Q
L
I
P
V
N
L
---
K
K
K
--
V
------------S
E
R
V
L
Y----
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
R
L
E
G
D
R
D
K
-----
V
----
R
F
V
Q
T
N
M
--
G
R
L
I
L
A
A
Q
---
M
D
----------
R
----------
T
---
G
--
A
D
F
A
V
M
S
G
G
G
I
R
D
--
S
I
---
E
---
A
G
-
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
-----
Q
M
--
K
--
P
D
S
G
A
Y
P
----------
Q
F
A
-
N
V
S
F
V
A
K
---
D
G
--
K
L
N
D
L
K
I
--------
K
----
G
E
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
-------------------------------
3
PsiBlast_PDB
71.30
22%
29
- C2 -
1HP1
7
USHA_ECOLI
A:
[8-468]
---
K
I
T
V
L
H
T
N
D
H
H
G
H
F
--------------------------------------
W
RNEYGEYG
L
A
A
Q
K
T
L
V
D
G
-------------
I
----------
R
K
E
V
A
A
E
-----
G
G
S
V
L
L
L
S
G
G
D
I
---
N
T
G
V
P
E
S
-----
D
L
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
-
F
D
N
P
L
T
V
L
-
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
-
K
S
T--
G
--
E
R
LF
K
P
W
A
L
-
F
K
R
Q
D
L
K
----
I
A
V
I
G
L
T
T
DDTAKIGN
P
E
-----
Y
F
T
D
-----
I
E
----
F
R
K
P
A
D
--
E
A
K
L
V
I
Q
E
--
L
Q
Q
T
--
E
-
K
P
-
D
I
I
I
A
A
T
H
M
G
H
---------------
Y
D
NGEHGSNAPG
D
-------------
V
----------------
E
M
A
R
A
-
L
P
AG
S
L
A
M
I
V
G
G
H
S
Q
D
P
V
CMAA
E
N
------------
K
------------------
K
Q
V
DYVPG
T
P
C
K
P
D
Q
Q
N
G
-------------
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
R
N
G
E
M
-
K
M
V
N
Y
Q
--
L
I
P
V
NLK
K
K
R
--
V
----------
L
Y
----------
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
R
L
E
G
D
R
D
K
-----
V
----
R
F
V
Q
T
N
M
--
G
R
L
I
L
A
A
Q
---
M
D
----------
R
----------
T
---
G
--
A
D
F
A
V
M
S
G
G
G
I
R
D
--
S
I
---
E
---
A
G
-
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
-----
Q
M
--
K
--
P
D
S
G
A
Y
P
----------
Q
F
A
-
N
V
S
F
V
A
K
---
D
G
--
K
L
N
D
L
K
I
--------
K
----
G
E
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
-------------------------------
10
PsiBlast_PDB
71.08
22%
37
- C2 -
1USH
7
USHA_ECOLI
A:
[33-502]
---
K
I
T
V
L
H
T
N
D
H
H
G
H
F
--------------------------------------
W
RNEYGEYG
L
A
A
Q
K
T
L
V
D
G
-------------
I
----------
R
K
E
V
A
A
E
-----
G
G
S
V
L
L
L
S
G
G
D
I
---
N
T
G
V
P
E
S
-----
D
L
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
-
F
D
N
P
L
T
V
L
-
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
-
K
S
T--
G
--
E
R
LF
K
P
W
A
L
-
F
K
R
Q
D
L
K
----
I
A
V
I
G
L
T
T
DDTAKIGN
P
E
-----
Y
F
T
D
-----
I
E
----
F
R
K
P
A
D
--
E
A
K
L
V
I
Q
E
--
L
Q
Q
T
--
E
-
K
P
-
D
I
I
I
A
A
T
H
M
G
H
---------------
Y
D
NGEHGSNAPG
D
-------------
V
----------------
E
M
A
R
A
-
L
P
AG
S
L
A
M
I
V
G
G
H
S
Q
D
P
V
CMAA
E
N
------------
K
------------------
K
Q
V
DYVPG
T
P
C
K
P
D
Q
Q
N
G
-------------
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
R
N
G
E
M
-
K
M
V
N
Y
Q
L
I
P
V
N
L
---
K
K
----------------RVLY------
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
R
L
E
G
D
R
D
K
-----
V
----
R
F
V
Q
T
N
M
--
G
R
L
I
L
A
A
Q
---
M
D
----------
R
----------
T
---
G
--
A
D
F
A
V
M
S
G
G
G
I
R
D
--
S
I
---
E
---
A
G
-
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
-----
Q
M
--
K
--
P
D
S
G
A
Y
P
----------
Q
F
A
-
N
V
S
F
V
A
K
---
D
G
--
K
L
N
D
L
K
I
--------
K
----
G
E
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
-------------------------------
11
PsiBlast_PDB
71.05
22%
30
- C2 -
4WWL
15
USHA_ECOLI
A:
[8-477]
---
K
I
T
V
L
H
T
N
D
H
H
G
H
F
--------------------------------------
W
RNEYGEYG
L
A
A
Q
K
T
L
V
D
G
-------------
I
----------
R
K
E
V
A
A
E
-----
G
G
S
V
L
L
L
S
G
G
D
I
---
N
T
G
V
P
E
S
-----
D
L
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
-
F
D
N
P
L
T
V
L
-
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
-
K
S
T--
G
--
E
R
LF
K
P
W
A
L
-
F
K
R
Q
D
L
K
----
I
A
V
I
G
L
T
T
DD
T
A
K
I
G
N
P
E
-----
Y
F
T
D
-----
I
E
----
F
R
K
P
A
D
--
E
A
K
L
V
I
Q
E
--
L
Q
Q
T
--
E
-
K
P
-
D
I
I
I
A
A
T
H
M
G
H
---------------
Y
D
NGEHGSNAPG
D
-------------
V
----------------
E
M
A
R
A
-
L
P
AG
S
L
A
M
I
V
G
G
H
S
Q
D
P
V
CMAA
E
N
------------
K
------------------
K
Q
V
DYVPG
T
P
C
K
P
D
Q
Q
N
G
-------------
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
-
R
N
G
E
M
K
M
V
N
Y
Q
L
I
P
V
N
L
---
K
K
K
--
V
----------
T
W
EDG
K
S
E
R
V
L
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
R
L
E
G
D
R
D
K
-----
V
----
R
F
V
Q
T
N
M
--
G
R
L
I
L
A
A
Q
---
M
D
----------
R
----------
T
---
G
--
A
D
F
A
V
M
S
G
G
G
I
R
D
--
S
I
---
E
---
A
G
-
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
-----
Q
M
--
K
--
P
D
S
G
A
Y
P
----------
Q
F
A
-
N
V
S
F
V
A
K
---
D
G
--
K
L
N
D
L
K
I
--------
K
----
G
E
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
-------------------------------
7
PsiBlast_PDB
70.71
22%
32
- C2 -
1HO5
4
USHA_ECOLI
A:
[8-477]
---
K
I
T
V
L
H
T
N
D
H
H
G
H
F
--------------------------------------
W
RNEYGEYG
L
A
A
Q
K
T
L
V
D
G
-------------
I
----------
R
K
E
V
A
A
E
-----
G
G
S
V
L
L
L
S
G
G
D
I
---
N
T
G
V
P
E
S
-----
D
L
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
-
F
D
N
P
L
T
V
L
-
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
-
K
S
T--
G
--
E
R
LF
K
P
W
A
L
-
F
K
R
Q
D
L
K
----
I
A
V
I
G
L
T
T
DDTAKIGN
P
E
-----
Y
F
T
D
-----
I
E
----
F
R
K
P
A
D
--
E
A
K
L
V
I
Q
E
--
L
Q
Q
T
--
E
-
K
P
-
D
I
I
I
A
A
T
H
M
G
H
---------------
Y
D
NGEHGSNAPG
D
-------------
V
----------------
E
M
A
R
A
-
L
P
AG
S
L
A
M
I
V
G
G
H
S
Q
D
P
V
CMAA
E
N
------------
K
------------------
K
Q
V
DYVPG
T
P
C
K
P
D
Q
Q
N
G
-------------
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
-
R
N
G
E
M
K
M
V
N
Y
Q
L
I
P
V
N
L
---
K
K
K
--
V
----------
T
W
EDG
K
S
E
R
V
L
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
R
L
E
G
D
R
D
K
-----
V
----
R
F
V
Q
T
N
M
--
G
R
L
I
L
A
A
Q
---
M
D
----------
R
----------
T
---
G
--
A
D
F
A
V
M
S
G
G
G
I
R
D
--
S
I
---
E
---
A
G
-
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
-----
Q
M
--
K
--
P
D
S
G
A
Y
P
----------
Q
F
A
-
N
V
S
F
V
A
K
---
D
G
--
K
L
N
D
L
K
I
--------
K
----
G
E
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
-------------------------------
8
PsiBlast_PDB
70.67
22%
31
- C2 -
1HPU
3
USHA_ECOLI
A:
[8-477]
---
K
I
T
V
L
H
T
N
D
H
H
G
H
F
--------------------------------------
W
RNEYGEYG
L
A
A
Q
K
T
L
V
D
G
-------------
I
----------
R
K
E
V
A
A
E
-----
G
G
S
V
L
L
L
S
G
G
D
I
---
N
T
G
V
P
E
S
-----
D
L
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
-
F
D
N
P
L
T
V
L
-
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
-
K
S
T--
G
--
E
R
LF
K
P
W
A
L
-
F
K
R
Q
D
L
K
----
I
A
V
I
G
L
T
T
DDTAKIGN
P
E
-----
Y
F
T
D
-----
I
E
----
F
R
K
P
A
D
--
E
A
K
L
V
I
Q
E
--
L
Q
Q
T
--
E
-
K
P
-
D
I
I
I
A
A
T
H
M
G
H
---------------
Y
D
NGEHGSNAPG
D
-------------
V
----------------
E
M
A
R
A
-
L
P
AG
S
L
A
M
I
V
G
G
H
S
Q
D
P
V
CMAA
E
N
------------
K
------------------
K
Q
V
DYVPG
T
P
C
K
P
D
Q
Q
N
G
-------------
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
-
R
N
G
E
M
K
M
V
N
Y
Q
L
I
P
V
N
L
---
K
K
K
--
V
----------
T
W
EDG
K
S
E
R
V
L
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
R
L
E
G
D
R
D
K
-----
V
----
R
F
V
Q
T
N
M
--
G
R
L
I
L
A
A
Q
---
M
D
----------
R
----------
T
---
G
--
A
D
F
A
V
M
S
G
G
G
I
R
D
--
S
I
---
E
---
A
G
-
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
-----
Q
M
--
K
--
P
D
S
G
A
Y
P
----------
Q
F
A
-
N
V
S
F
V
A
K
---
D
G
--
K
L
N
D
L
K
I
--------
K
----
G
E
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
-------------------------------
35
HHSearch
70.59
19%
16
- C2 -
4Q7F
3
?
A:
[18-511]
--
S
N
I
A
F
Y
V
V
S
D
V
H
G
Y
I
----
F
---------------
P
TDFTSRNQYQPMG----
L
------------
L
L
A
N
H
V
-------------
I
E
Q
D
-------
R
R
Q
Y
---------
D
Q
S
F
K
I
D
N
G
D
F
L
Q
G
S
P
-
F
C
N
Y
L
I
A
H
S
G
S
S
Q
P
L
V
D
F
--
Y
N
R
M
A
F
D
F
G
T
L
G
N
H
E
F
N
Y
-
G
L
P
Y
L
-
K
D
T
L
R
R
L
N
Y
P
V
L
C
A
N
I
Y
E
N
D
S
---
T
---
L
----
T
D
N
G
V
K
Y
F
Q
-
V
G
D
Q
T
V
G
V
I
G
L
T
T
--------
Q
F
-----
I
P
H
W
E----
Q
P
EHI-
Q
S
L
T
F
H
--
S
A
F
E
I
L
Q
Q
Y
L
P
E
M
K
--
R
-
H
A
-
D
I
I
V
V
C
Y
H
G
G
F
---------------
E
K
----------
D
-------------
L
ESGTPTEVLTGENE
G
Y
A
M
L
E
A
F
S
K
--
D
I
D
I
F
I
T
G
H
Q
H
R
Q
I
----
A
E
------------
R
--------------------
F
-------------
K
Q
-------------
T
A
V
I
Q
P
G
T
R
G
T
T
V
G
R
V
V
L
S
T
-
D
E
Y
E
-
N
-
L
S
V
E
--
S
C
E
L
---
L
P
V
--
I
----------
D
D
----------
S
--
T
F
T
I
D
-------
E
D
D
Q
H
L
R
K
Q
L
E
D
W
L
D
Y
E
I
T
T
L
P
Y
D
M
T
I
NH
A
F
E
A
----
R
V
A
P
H
P
F
--
T
N
F
M
N
Y
A
L
---
L
E
----------
K
----------
S
---
D
--
A
D
V
A
C
T
A
L
F
D
S
A
S
--
G
F
-------
K
Q
-
V
V
T
M
R
D
V
I
N
N
Y
P
F
P
N
-
T
F
K
V
L
A
V
S
G
A
K
L
K
E
A
I
E
R
S
A
E
Y
F
D
V
K
N
--
D
E
V
S
V
S
A
D
F
L
E
P
K
PQH
F
N
Y
D
I
Y
G
-
G
V
S
Y
T
I
H
V
G
R
P
K
G
Q
R
V
S
N
M
M
I
--------
Q
----
G
H
A
V
D
L
K
Q
T
Y
T
I
C
V
N
N
Y
R
A
V
G
G
G
Q
Y
D
M
Y
I
D
A
P
-
V
V
K
D
I
Q
V
E
G
A
Q
L
L
I
D
F
L
S
N
12
PsiBlast_PDB
70.29
22%
32
- C2 -
1OID
1
USHA_ECOLI
A:
[8-477]
---
K
I
T
V
L
H
T
N
D
H
H
G
H
F
--------------------------------------
W
RNEYGEYG
L
A
A
Q
K
T
L
V
D
G
-------------
I
----------
R
K
E
V
A
A
E
-----
G
G
S
V
L
L
L
S
G
G
D
---
I
N
T
G
V
P
E
S
-----
D
L
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
-
F
D
N
P
L
T
V
L
-
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
-
K
S
T--
G
--
E
R
LF
K
P
W
A
L
-
F
K
R
Q
D
L
K
----
I
A
V
I
G
L
T
T
DDTAKIGN
P
E
-----
Y
F
T
D
-----
I
E
----
F
R
K
P
A
D
--
E
A
K
L
V
I
Q
E
--
L
Q
Q
T
--
E
-
K
P
-
D
I
I
I
A
A
T
H
M
G
H
---------------
Y
D
NGEHGCNAPG
D
-------------
V
----------------
E
M
A
R
A
-
L
P
AG
S
L
A
M
I
V
G
G
H
S
Q
D
P
V
CMAA
E
N
------------
K
------------------
K
Q
V
DYVPG
T
P
C
K
P
D
Q
Q
N
G
-------------
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
-
R
N
G
E
M
K
M
V
N
Y
Q
L
I
P
V
N
L
---
K
K
K
--
V
----------
T
W
EDG
K
S
E
R
V
L
Y
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
R
L
E
G
D
R
D
K
-----
V
----
R
F
V
Q
T
N
M
--
G
R
L
I
L
A
A
Q
---
M
D
----------
R
----------
T
---
G
--
A
D
F
A
V
M
S
G
G
G
I
R
D
--
S
I
---
E
---
A
G
-
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
-----
Q
M
--
K
--
P
D
S
G
A
Y
P
----------
Q
F
A
-
N
V
S
F
V
A
K
---
D
G
--
K
L
N
D
L
K
I
--------
K
----
G
E
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
-------------------------------
34
HHSearch
69.80
20%
36
- C2 -
1HP1
7
USHA_ECOLI
A:
[6-498]
-
T
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
F
----
W
---------------
R
NEYGEYG----------
L
------------
A
A
Q
K
T
L
-------------
V
D
G
I
-------
R
K
E
V
A
A
E
-----
G
G
S
V
L
L
L
S
G
G
D
I
N
T
G
V
P
-
E
S
D
L
-----
Q
D
A
E
P
D
F
R
G
--
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
-
P
L
T
V
L
-
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
K
S
T
---
G
--
E
R
----
L
F
K
P
W
A
L
F
K
-
R
Q
D
L
K
I
A
V
I
G
L
T
T
--------
D
D
-----
T
A
K
I
G----
N
P
EYF-
T
D
I
E
F
R
--
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
-
K
P
-
D
I
I
I
A
A
T
H
M
G
H
---------------
Y
D
NGEHGSNAPG
D
-------------
V
----------------
E
M
A
R
A
-
L
P
AG
S
L
A
M
I
V
G
G
H
S
Q
D
P
V
----
C
M
------------
A
AENKKQVDYVPG
T
P
C
K
P
-
D
Q
Q
-------------
N
G
-------------
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
-
R
N
G
E
-
M
K
M
--
V
--
N
Y
Q
L
---
I
P
V
--
N
LKKKRVLYTP
E
I
----------
A
-
E
N
Q
Q
M
I
-------
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
R
L
E
G
-----
D
R
D
K
V
R
F
V
Q
T
N
M
--
G
R
L
I
L
A
A
Q
---
M
D
----------
R
----------
T
---
G
--
A
D
F
A
V
M
S
G
G
G
I
R
D
--
S
I
---
E
---
A
G
-
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
Q
M
K
P
---------
D
S
G
A
Y
P
----------
Q
F
A
-
N
V
S
F
V
A
K
-----
D
G
K
L
N
D
L
K
I
--------
K
----
G
E
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
D
N
K
P
-
G
Y
V
N
T
G
F
I
D
A
E
V
L
K
A
Y
I
Q
K
9
PsiBlast_PDB
69.35
22%
22
- C2 -
2USH
7
USHA_ECOLI
A:
[33-502]
---
K
I
T
V
L
H
T
N
D
H
H
G
H
F
--------------------------------------
W
RNEYGEYG
L
A
A
Q
K
T
L
V
D
G
-------------
I
----------
R
K
E
V
A
A
E
-----
G
G
S
V
L
L
L
S
G
G
D
I
---
N
T
G
V
P
E
S
-----
D
L
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
-
F
D
N
P
L
T
V
L
-
R
Q
Q
E
K
W
A
K
F
P
L
L
S
A
N
I
Y
Q
-
K
S
T--
G
--
E
R
LF
K
P
W
A
L
-
F
K
R
Q
D
L
K
----
I
A
V
I
G
L
T
T
DDTAK----------
Y
F
T
D
-----
I
E
----
F
R
K
P
A
D
--
E
A
K
L
V
I
Q
E
--
L
Q
Q
T
--
E
-
K
P
-
D
I
I
I
A
A
T
H
M
G
H
---------------
Y
D
NGEHGSNAPG
D
-------------
V
----------------
E
M
A
R
A
-
L
P
AG
S
L
A
M
I
V
G
G
H
S
Q
D
P
V
CMAA
E
N
------------
K
------------------
K
Q
V
D
Y
V
P
G
T
P
C
K
P
D
Q
Q
N
G
-------------
I
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
R
N
G
E
M
-
K
M
V
N
Y
Q
L
I
P
V
N
L
---
K
K
K
--
V
------------S
E
R
V
L
Y----
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
R
L
E
G
D
R
D
K
-----
V
----
R
F
V
Q
T
N
M
--
G
R
L
I
L
A
A
Q
---
M
D
----------
R
----------
T
---
G
--
A
D
F
A
V
M
S
G
G
G
I
R
D
--
S
I
---
E
---
A
G
-
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
-----
Q
M
--
K
--
P
D
S
G
A
Y
P
----------
Q
F
A
-
N
V
S
F
V
A
K
------------
K
I
--------
K
----
G
E
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
-------------------------------
31
HHSearch
68.67
20%
28
- C2 -
4H2G
5
5NTD_HUMAN
A:
[23-531]
-
P
W
E
L
T
I
L
H
T
N
D
V
H
S
R
L
----
E
---------------
Q
TSEDSSKCVDASRCMGG
V
------------
A
R
L
F
T
K
-------------
V
Q
Q
I
-------
R
R
A
E
---------
P
N
V
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
-
W
F
T
V
-----
Y
K
G
A
E
V
A
H
F
--
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
-
G
V
E
G
L
I
E
P
L
L
K
E
A
K
F
P
I
L
S
A
N
I
K
A
K
G
P
---
L
A
S
Q
I
--
S
G
L
Y
L
P
Y
K
V
L
P
-
V
G
D
E
V
V
G
I
V
G
Y
T
S
--------
K
E
-----
T
P
F
L
S----
N
P
G---
T
N
L
V
F
E
--
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
--
T
L
N
V
-
N
K
I
I
A
L
G
H
S
G
F
---------------
E
M
----------
D
-------------
K
----------------
L
I
A
Q
K
-
V
R
--
G
V
D
V
V
V
G
G
H
S
N
T
F
L
----
Y
T
------------
G
NPPSKEVPAGKYPFIVTS
D
D
G
-------------
R
K
-------------
V
P
V
V
Q
A
Y
A
F
G
K
Y
L
G
Y
L
K
I
E
F
-
D
E
R
G
-
N
-
V
I
S
S
--
H
G
N
P
---
I
L
L
--
D
S---------
S
I
----------
P
-
E
D
P
S
I
K
-------
A
D
I
N
K
W
R
I
K
L
D
D
Y
S
T
Q
E
L
G
K
T
I
V
Y
L
D
G
SSQS-
C
----
R
F
R
E
C
N
M
--
G
N
L
I
C
D
A
M
---
I
N
----------
N
N
LRHADEMFW
N
---
H
--
V
S
M
C
I
L
N
G
G
G
I
R
S
--
P
I
---
D
ERN
D
G
-
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
-
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
H
S
V
H
R
Y
G
--------
Q
S
T
G
E
F
L
----------
Q
V
G
-
G
I
H
V
V
Y
D
L
S
R
K
P
G
D
R
V
V
K
L
D
V
L
C
TACA
V
P
S
----
Y
D
P
L
K
M
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
G
D
G
F
Q
M
I
K
D
E
-
L
L
R
H
D
S
G
D
Q
D
I
N
V
V
S
T
Y
I
S
K
37
HHSearch
67.54
19%
-1
- C2 -
2WDC
17
?
A:
[81-536]
--
P
L
A
Y
L
L
S
Y
V
D
F
V
E
L
A
----
R
---------------
T
FGPIGG-----------
M
------------
G
A
L
T
A
L
-------------
I
R
D
Q
-------
K
A
R
V
E
A
E
-----
G
G
K
A
L
V
L
D
G
G
D
T
W
T
N
S
G
-
L
S
L
L
-----
T
R
G
E
A
V
V
R
W
--
Q
N
L
V
G
V
D
H
M
V
-
S
H
W
E
W
T
L
-
G
R
E
R
V
-
E
E
L
L
G
L
F
R
G
E
F
L
S
Y
N
I
V
D
D
L
F
---
G
--
D
P
----
L
F
P
A
Y
R
I
H
R
-
V
G
P
Y
A
L
A
V
V
G
A
S
Y
--------
P
Y
-----
V
K
V
S
-----
H
P
ESFT
E
G
L
S
F
A
--
L
D
E
R
R
L
Q
E
A
V
D
K
A
R
--
A
E
G
A
-
N
A
V
V
L
L
S
H
N
G
M
---------------
Q
L
----------
D
-------------
A
----------------
A
L
A
E
R
-
I
R
--
G
I
D
L
I
L
S
G
H
T
H
D
L
T
----
P
R
------------
P
------------------
W
R
V
-------------
G
K
-------------
T
W
I
V
A
G
S
A
A
G
K
A
L
M
R
V
D
L
K
L
-
W
K
G
G
---
I
A
N
L
--
R
V
R
V
---
L
P
V
--
L
AE--------
H
L
----------
P
-
K
A
E
D
V
E
-------
A
F
L
K
A
Q
L
A
P
H
Q
D
H
L
F
T
P
L
A
V
S
E
T
L
L
Y
K
-----
R
----
D
T
L
Y
S
T
W
--
D
Q
L
V
G
E
A
V
---
K
A
----------
I
----------
Y
------
P
E
V
E
V
V
F
S
P
A
V
R
W
G
T
T
I
---
L
---
P
G
Q
A
I
T
W
D
H
L
Y
A
Y
T
G
F
T
Y
P
E
L
Y
L
F
Y
L
R
G
A
Q
I
K
A
V
L
E
D
I
A
S
N
V
F
T
S
D
PF
Y
--
Q
Q
G
G
D
V
S
----------
R
V
F
-
G
L
R
Y
V
L
D
P
D
A
P
T
G
E
R
V
R
E
V
E
V
--------
G
----
G
R
P
L
D
P
N
R
R
Y
L
A
A
A
Y
G
G
R
------
L
Q
R
V
G
E
A
K
--
P
G
Y
E
P
R
P
I
Y
E
V
L
A
E
Y
L
R
S
14
PsiBlast_PDB
67.02
20%
12
- C2 -
4H2I
5
5NTD_HUMAN
A:
[3-413]
---
E
L
T
I
L
H
T
N
D
V
H
S
R
L
EQTS
E
---------------
D
-----------------
S
------------
S
K
C
V
D
A
SRCMGG
V
A
R
L
F
T
K
V
Q
Q
I
-------
R
R
A
E
P
N
---------
V
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
-
V
-----
Y
K
G
A
E
V
A
H
F
--
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
G
V
E
G
L
I
-
E
P
L
L
K
E
A
K
F
P
I
L
S
A
N
I
K
A
-
K
G
PLA
S
--
Q
I
--
S
G
L
Y
L
P
Y
K
V
L
P
V
G
D
E
V
-
V
G
I
V
G
Y
T
S
--------
K
E
-----
T
P
F
L
-----
S
N
----
P
G
T
N
L
V
F
E
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
--
T
L
N
V
-
N
K
I
I
A
L
G
H
S
G
F
---------------
E
M
----------
D
-------------
K
----------------
L
I
A
Q
K
-
V
R
--
G
V
D
V
V
V
G
G
H
S
N
T
F
L
----
Y
T
------------
G
NPPSK-------------
E
V
P
-------------
A
G
KYP
F
I
V
T
S
DD
G
R
K
V
P
V
V
Q
A
Y
A
F
G
K
Y
L
G
Y
L
K
I
E
F
-
D
E
R
G
-
N
V
I
S
S
H
--
G
N
P
I
L
LD
S
S
I
--
P
----------
E
D
----------
P
S
I
K
A
D
I
N
-------
K
W
R
I
K
L
D
D
Y
S
T
Q
E
L
G
K
T
I
V
Y
L
D
G
S
S
Q
S
-----
C
----
R
F
R
E
C
N
M
--
G
N
L
I
C
D
A
M
---
I
N
N
N
L
R
HADEMF
W
----------
N
---
H
--
V
S
M
C
I
L
N
G
G
G
I
R
S
--
P
I
D
ER
N
---
D
G
-
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
-
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
H
S
------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
66.87
23%
-1
- C2 -
2Z1A
4
?
A:
[30-426]
----
L
T
L
V
H
T
N
D
T
H
A
H
L
----
E
----------------------------------------------
P
V
E
L
T
L
-------------
S
G
E
K
T
P
V
G
G
V
A
R
R
V
A
L
F
D
R
V
W
A
R
A
K
N
P
L
F
L
D
A
G
D
V
F
Q
G
T
L
Y
F
N
Q
Y
-----
R
-
G
L
A
D
R
Y
F
--
M
H
R
L
R
Y
R
A
M
A
L
G
N
H
E
-
F
D
L
G
P
G
P
L
-
A
D
F
L
K
G
A
R
F
K
V
V
S
A
N
V
D
A
-
S
R
---
E
--
P
R
--
L
K
G
L
F
A
P
Y
A
V
V
V
V
G
G
E
R
V
G
I
I
G
L
T
T
--------
P
D
-----
T
R
E
I
-----
S
N
----
P
G
P
T
V
A
F
L
D
P
Y
E
S
A
Q
K
A
V
Y
E
L
L
--
A
-
K
G
V
N
K
I
V
V
L
S
H
L
G
Y
---------------
G
E
----------
D
-------------
L
----------------
K
L
A
R
R
-
L
V
--
G
V
Q
V
I
V
G
G
H
S
H
T
L
L
----
G
S
F
PHKELSPAGPY
P
------------------
T
V
V
-------------
K
N
PEG
K
D
--------
V
L
V
V
Q
A
W
E
W
G
K
V
V
G
L
L
E
V
T
F
-
D
A
K
G
-
E
L
L
A
Y
K
--
G
E
A
L
---
L
M
T
--
P
----------
E
A
----------
A
P
E
D
F
F
A
K
E
A
L
L
---
A
Y
A
Q
P
V
M
A
L
M
Q
Q
V
I
A
E
A
K
V
D
L
V
G
E
R
A
V
-----
V
----
R
R
R
E
S
N
L
--
G
N
L
I
T
D
G
M
L
W
K
T
R
----------
N
----------
A
---
G
--
T
Q
I
A
L
Q
N
G
G
G
I
R
A
--
S
I
---
P
---
K
G
-
P
I
T
V
G
K
V
Y
E
V
L
P
F
G
N
-
T
L
V
V
M
D
L
K
G
K
E
I
L
A
A
L
E
N
G
V
S
Q
---------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
66.54
20%
13
- C2 -
4H2G
5
5NTD_HUMAN
A:
[25-435]
---
E
L
T
I
L
H
T
N
D
V
H
S
R
L
EQTS
E
---------------
D
-----------------
S
------------
S
K
C
V
D
A
SRCMGG
V
A
R
L
F
T
K
V
Q
Q
I
-------
R
R
A
E
P
N
---------
V
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
-
V
-----
Y
K
G
A
E
V
A
H
F
--
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
G
V
E
G
L
I
-
E
P
L
L
K
E
A
K
F
P
I
L
S
A
N
I
K
A
-
K
G
P
L
A
S
--
Q
I
--
S
G
L
Y
L
P
Y
K
V
L
P
V
G
D
E
V
-
V
G
I
V
G
Y
T
S
--------
K
E
-----
T
P
F
L
-----
S
N
----
P
G
T
N
L
V
F
E
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
--
T
L
N
V
-
N
K
I
I
A
L
G
H
S
G
F
---------------
E
M
----------
D
-------------
K
----------------
L
I
A
Q
K
-
V
R
--
G
V
D
V
V
V
G
G
H
S
N
T
F
L
----
Y
T
------------
G
NPPSK-------------
E
V
P
-------------
A
G
KYPFIVTSDDG
R
K
V
P
V
V
Q
A
Y
A
F
G
K
Y
L
G
Y
L
K
I
E
F
-
D
E
R
G
-
N
V
I
S
S
H
--
G
N
P
I
L
LD
S
S
I
--
P
----------
E
D
----------
P
S
I
K
A
D
I
N
-------
K
W
R
I
K
L
D
D
Y
S
T
Q
E
L
G
K
T
I
V
Y
L
D
G
S
S
Q
S
-----
C
----
R
F
R
E
C
N
M
--
G
N
L
I
C
D
A
M
---
I
N
N
N
LRHADEMF
W
----------
N
---
H
--
V
S
M
C
I
L
N
G
G
G
I
R
S
--
P
I
D
ER
N
---
D
G
-
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
-
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
H
S
------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
66.48
20%
15
- C2 -
4H2F
4
5NTD_HUMAN
A:
[25-435]
---
E
L
T
I
L
H
T
N
D
V
H
S
R
L
EQTS
E
---------------
D
-----------------
S
------------
S
K
C
V
D
A
SR
C
M
G
G
V
A
R
L
F
T
K
V
Q
Q
I
-------
R
R
A
E
P
N
---------
V
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
-
V
-----
Y
K
G
A
E
V
A
H
F
--
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
G
V
E
G
L
I
-
E
P
L
L
K
E
A
K
F
P
I
L
S
A
N
I
K
A
-
K
G
PLA
S
--
Q
I
--
S
G
L
Y
L
P
Y
K
V
L
P
V
G
D
E
V
-
V
G
I
V
G
Y
T
S
--------
K
E
-----
T
P
F
L
-----
S
N
----
P
G
T
N
L
V
F
E
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
--
T
L
N
V
-
N
K
I
I
A
L
G
H
S
G
F
---------------
E
M
----------
D
-------------
K
----------------
L
I
A
Q
K
-
V
R
--
G
V
D
V
V
V
G
G
H
S
N
T
F
L
----
Y
T
------------
G
NPPSK-------------
E
V
P
-------------
A
G
KYPF
I
V
T
S
DDG
R
K
V
P
V
V
Q
A
Y
A
F
G
K
Y
L
G
Y
L
K
I
E
F
-
D
E
R
G
-
N
V
I
S
S
H
--
G
N
P
I
L
LD
S
S
I
--
P
----------
E
D
----------
P
S
I
K
A
D
I
N
-------
K
W
R
I
K
L
D
D
Y
S
T
Q
E
L
G
K
T
I
V
Y
L
D
G
S
S
Q
S
-----
C
----
R
F
R
E
C
N
M
--
G
N
L
I
C
D
A
M
---
I
N
N
N
L
R
HADEMF
W
----------
N
---
H
--
V
S
M
C
I
L
N
G
G
G
I
R
S
--
P
I
D
ER
N
---
D
G
-
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
-
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
H
S
------------------------------------------------------------------------------------------------------------------------