@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu32530: (2016-07-24 )
MEKQKLSVKNSITDYIEWLAQYGASADGGVTRLLYTKEWMDAQLAVKTEMSSFGLETRFDDVGNVFGRLSGTQSPDEVIVTGSHIDTVINGGKYDGAYGVLAAMLALKQLKETYGAPKKTLEAVSLCEEEGSRFPMTYWGSGNMTGVFSEQDAKEPRDESGVSLQTAMHESGFGKGVFQSAYRTDISAFVELHIEQGKTLEMSGRDLGIVTSIAGQRRYLVTLEGECNHAGTTSMKWRKDPLAASSRIIHELLLRSDELPDELRLTCGKITAEPNVANVIPGRVQFSIDIRHQHQHVLEQFHQDMVALINGICLQKGIRAVIDEYMRIEPVPMDERLKAAAFETALENGFSCEEMVSGAGHDAQMIGRRYPACMLFVPSRGGVSHSPKEYTSARQLEIGVRALTDLLYKLAY
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70.-.-......80........90-.-.......100.......110......-.120.......130.......140.....--..------150----...---..--....160.......170..--..--.-------..--..-180...--..--....190.......200.......210.......220.......230.--....-..240-.........---250....--...----260---.........270-.......280.......290.......300.......310..--.....320........330.......340-.......350-----........360.....-..370.......380.......390.......400.......410
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEKQKLS
V
K
N
S
I
T
D
Y
I
E
W
L
A
QYGASADG
G
V
T
R
L
L
Y
T
K
EWMDA
Q
L
A
V
K
T
E
M
S
SFGLET
R
F
D
D
V
G
N
V
F
G
RLSGT-Q-SP
D
E
V
I
V
TGSH
I
D
T
VING-G-KYD
G
A
Y
G
V
L
A
A
M
L
A
L
K
Q
L
K
E
T
YGA
P
K
-
K
T
L
E
A
V
S
L
C
E
EEGSRF
P
M
T
Y
WGSGN
M
T
G
V
--FS------E------QDA---KE--PRDESGV
S
L
Q
T
A
M
HE--SG--FG--
K
-------
G
V
--
F
Q
-
S
--
A
Y
R
--
T
D
--
I
S
A
F
V
E
L
H
IEQG
K
T
L
EMSGRD
L
G
I
V
T
SIAGQ
R
R
Y
L
V
T
L
EGECNHAGTT--SMKW-RKD---PL
A
A
S
S
R
I
I
---
H
E
L
L
LRS--DEL----
P
-----
D
E
L
R
L
TCGKITA-EPN
V
A
NVIPG
R
V
Q
F
S
I
D
I
R
H
Q
H
Q
H
V
L
E
Q
F
H
Q
D
M
V
A
L
I
N
G
I
C
L
--
Q
K
G
I
R
A
V
-
I
D
E
Y
MRIEPV
P
M
D
E
R
L
K
A
A
A
F
-
E
T
A
L
ENGF
S
------
C
E
E
M
V
SGAG
H
D
A
Q
M
I
G
-RRY
P
A
C
M
L
F
VPSRGGVSHS
P
K
E
YTS
A
R
Q
L
E
I
G
V
R
A
L
T
D
L
L
Y
K
LAY
2
PsiBlast_PDB
97.07
47%
-73
- C1 -
4PXD
3
ALLC_ECOLI
A:
[8-411]
--------
R
Q
A
I
E
E
T
L
P
W
L
S
S
F
G
A
D
P
A
G
G
M
T
R
L
L
Y
S
P
E
W
L
E
T
Q
Q
Q
F
K
K
R
M
A
A
S
G
L
E
T
R
F
D
E
V
G
N
L
Y
G
R
L
N
G
T
-
E
-
Y
P
Q
E
V
V
L
S
G
S
H
I
D
T
V
V
N
G
-
G
-
N
L
D
G
Q
F
G
A
L
A
A
W
L
A
I
D
W
L
K
T
Q
Y
G
A
P
L
-
R
T
V
E
V
V
A
M
A
E
A
E
G
S
R
F
P
Y
V
F
W
G
S
K
N
I
F
G
L
--
A
N
------
P
------
D
D
V
---
R
N
--
I
C
D
A
K
G
N
S
F
V
D
A
M
K
A
--
C
G
--
F
T
--
L
-------
P
N
--
A
P
-
L
--
T
P
R
--
Q
D
--
I
K
A
F
V
E
L
H
I
E
Q
G
C
V
L
E
S
N
G
Q
S
I
G
V
V
N
A
I
V
G
Q
R
R
Y
T
V
T
L
N
G
E
S
N
H
A
G
T
T
--
P
M
G
Y
-
R
R
D
---
T
V
Y
A
F
S
R
I
C
---
H
Q
S
V
E
K
A
--
K
R
M
----
G
-----
D
P
L
V
L
T
F
G
K
V
E
P
-
R
P
N
T
V
N
V
V
P
G
K
T
T
F
T
I
D
C
R
H
T
D
A
A
V
L
R
D
F
T
Q
Q
L
E
N
D
M
R
A
I
C
D
--
E
M
D
I
G
I
D
-
I
D
L
W
M
D
E
E
P
V
P
M
N
K
E
L
V
A
T
L
T
-
E
L
C
E
R
E
K
L
N
------
Y
R
V
M
H
S
G
A
G
H
D
A
Q
I
F
A
-
P
R
V
P
T
C
M
I
F
I
P
S
I
N
G
I
S
H
N
P
A
E
R
T
N
I
T
D
L
A
E
G
V
K
T
L
A
L
M
L
Y
Q
L
A
W
22
PsiBlast_CBE
96.64
47%
-71
- C1 -
4PXD
3
ALLC_ECOLI
B:
[8-411]
--------
R
Q
A
I
E
E
T
L
P
W
L
S
S
F
G
A
D
P
A
G
G
M
T
R
L
L
Y
S
P
E
W
L
E
T
Q
Q
Q
F
K
K
R
M
A
A
S
G
L
E
T
R
F
D
E
V
G
N
L
Y
G
R
L
N
G
T
-
E
-
Y
P
Q
E
V
V
L
S
G
S
H
I
D
T
V
V
N
G
-
G
-
N
L
D
G
Q
F
G
A
L
A
A
W
L
A
I
D
W
L
K
T
Q
Y
G
A
P
L
-
R
T
V
E
V
V
A
M
A
E
A
E
G
S
R
F
P
Y
V
F
W
G
S
K
N
I
F
G
L
--
A
N
------
P
------
D
D
V
---
R
N
--
I
C
D
A
K
G
N
S
F
V
D
A
M
K
A
--
C
G
--
F
T
--
L
-------
P
N
--
A
P
-
L
--
T
P
R
--
Q
D
--
I
K
A
F
V
E
L
H
I
E
Q
G
C
V
L
E
S
N
G
Q
S
I
G
V
V
N
A
I
V
G
Q
R
R
Y
T
V
T
L
N
G
E
S
N
H
A
G
T
T
--
P
M
G
Y
-
R
R
D
---
T
V
Y
A
F
S
R
I
C
---
H
Q
S
V
E
K
A
--
K
R
M
----
G
-----
D
P
L
V
L
T
F
G
K
V
E
P
-
R
P
N
T
V
N
V
V
P
G
K
T
T
F
T
I
D
C
R
H
T
D
A
A
V
L
R
D
F
T
Q
Q
L
E
N
D
M
R
A
I
C
D
--
E
M
D
I
G
I
D
-
I
D
L
W
M
D
E
E
P
V
P
M
N
K
E
L
V
A
T
L
T
-
E
L
C
E
R
E
K
L
N
------
Y
R
V
M
H
S
G
A
G
H
D
A
Q
I
F
A
-
P
R
V
P
T
C
M
I
F
I
P
S
I
N
G
I
S
H
N
P
A
E
R
T
N
I
T
D
L
A
E
G
V
K
T
L
A
L
M
L
Y
Q
L
A
W
1
PsiBlast_PDB
95.08
47%
-77
- C1 -
1Z2L
5
ALLC_ECOLI
A:
[8-411]
--------
R
Q
A
I
E
E
T
L
P
W
L
S
S
F
G
A
D
P
A
G
G
M
T
R
L
L
Y
S
P
E
W
L
E
T
Q
Q
Q
F
K
K
R
M
A
A
S
G
L
E
T
R
F
D
E
V
G
N
L
Y
G
R
L
N
G
T
-
E
-
Y
P
Q
E
V
V
L
S
G
S
H
I
D
T
V
V
N
G
-
G
-
N
L
D
G
Q
F
G
A
L
A
A
W
L
A
I
D
W
L
K
T
Q
Y
G
A
P
L
-
R
T
V
E
V
V
A
M
A
E
E
E
G
S
R
F
P
Y
V
F
W
G
S
K
N
I
F
G
L
--
A
N
------
P
------
D
D
V
---
R
N
--
I
C
D
A
K
G
N
S
F
V
D
A
M
K
A
--
C
G
--
F
T
--
L
-------
P
N
--
A
P
-
L
--
T
P
R
--
Q
D
--
I
K
A
F
V
E
L
H
I
E
Q
G
C
V
L
E
S
N
G
Q
S
I
G
V
V
N
A
I
V
G
Q
R
R
Y
T
V
T
L
N
G
E
S
N
H
A
G
T
T
--
P
M
G
Y
-
R
R
D
---
T
V
Y
A
F
S
R
I
C
---
H
Q
S
V
E
K
A
--
K
R
M
----
G
-----
D
P
L
V
L
T
F
G
K
V
E
P
-
R
P
N
T
V
N
V
V
P
G
K
T
T
F
T
I
D
C
R
H
T
D
A
A
V
L
R
D
F
T
Q
Q
L
E
N
D
M
R
A
I
C
D
--
E
M
D
I
G
I
D
-
I
D
L
W
M
D
E
E
P
V
P
M
N
K
E
L
V
A
T
L
T
-
E
L
C
E
R
E
K
L
N
------
Y
R
V
M
H
S
G
A
G
H
D
A
Q
I
F
A
-
P
R
V
P
T
C
M
I
F
I
P
S
I
N
G
I
S
H
N
P
A
E
R
T
N
I
T
D
L
A
E
G
V
K
T
L
A
L
M
L
Y
Q
L
A
W
21
PsiBlast_CBE
94.62
47%
-73
- C1 -
1Z2L
5
ALLC_ECOLI
B:
[8-411]
--------
R
Q
A
I
E
E
T
L
P
W
L
S
S
F
G
A
D
P
A
G
G
M
T
R
L
L
Y
S
P
E
W
L
E
T
Q
Q
Q
F
K
K
R
M
A
A
S
G
L
E
T
R
F
D
E
V
G
N
L
Y
G
R
L
N
G
T
-
E
-
Y
P
Q
E
V
V
L
S
G
S
H
I
D
T
V
V
N
G
-
G
-
N
L
D
G
Q
F
G
A
L
A
A
W
L
A
I
D
W
L
K
T
Q
Y
G
A
P
L
-
R
T
V
E
V
V
A
M
A
E
E
E
G
S
R
F
P
Y
V
F
W
G
S
K
N
I
F
G
L
--
A
N
------
P
------
D
D
V
---
R
N
--
I
C
D
A
K
G
N
S
F
V
D
A
M
K
A
--
C
G
--
F
T
--
L
-------
P
N
--
A
P
-
L
--
T
P
R
--
Q
D
--
I
K
A
F
V
E
L
H
I
E
Q
G
C
V
L
E
S
N
G
Q
S
I
G
V
V
N
A
I
V
G
Q
R
R
Y
T
V
T
L
N
G
E
S
N
H
A
G
T
T
--
P
M
G
Y
-
R
R
D
---
T
V
Y
A
F
S
R
I
C
---
H
Q
S
V
E
K
A
--
K
R
M
----
G
-----
D
P
L
V
L
T
F
G
K
V
E
P
-
R
P
N
T
V
N
V
V
P
G
K
T
T
F
T
I
D
C
R
H
T
D
A
A
V
L
R
D
F
T
Q
Q
L
E
N
D
M
R
A
I
C
D
--
E
M
D
I
G
I
D
-
I
D
L
W
M
D
E
E
P
V
P
M
N
K
E
L
V
A
T
L
T
-
E
L
C
E
R
E
K
L
N
------
Y
R
V
M
H
S
G
A
G
H
D
A
Q
I
F
A
-
P
R
V
P
T
C
M
I
F
I
P
S
I
N
G
I
S
H
N
P
A
E
R
T
N
I
T
D
L
A
E
G
V
K
T
L
A
L
M
L
Y
Q
L
A
W
59
HHSearch
83.80
45%
7
- C1 -
4PXD
3
ALLC_ECOLI
A:
[5-410]
-----
T
H
F
R
Q
A
I
E
E
T
L
P
W
L
S
S
F
G
A
D
P
A
G
G
M
T
R
L
L
Y
S
P
E
W
L
E
T
Q
Q
Q
F
K
K
R
M
A
A
S
G
L
E
T
R
F
D
E
V
G
N
L
Y
G
R
L
N
G
T
-
E
Y
P
Q
-
E
V
V
L
S
G
S
H
I
D
T
V
V
N
G
-
G
N
L
D
G
Q
F
G
A
L
A
A
-
W
L
A
I
D
W
L
K
T
Q
-
Y
G
A
P
L
R
T
V
E
V
V
A
M
A
E
A
E
G
S
R
F
P
Y
V
F
W
G
S
K
N
I
F
G
L
--
A
N
------
P
------
D
D
V
---
R
N
--
I
C
D
A
K
G
N
S
F
V
D
A
M
K
A
--
C
G
--
F
T
LP
N
-------
A
P
-----
L
--
T
P
R
--
Q
D
--
I
K
A
F
V
E
L
H
I
E
Q
G
C
V
L
E
S
N
G
Q
S
I
G
V
V
N
A
I
V
G
Q
R
R
Y
T
V
T
L
N
G
E
S
N
H
A
G
T
---
T
P
M
G
Y
R
R
D
---
T
V
Y
A
F
S
R
I
C
---
H
Q
S
------
V
E
K
A
K
R
M
G
-----
D
P
L
V
L
T
F
G
K
V
E
P
-
R
P
N
T
V
N
V
V
P
G
K
T
T
F
T
I
D
C
R
H
T
D
A
A
V
L
R
D
F
T
Q
Q
L
E
N
D
M
R
A
I
C
D
--
E
M
D
I
G
I
D
-
I
D
L
W
M
D
E
E
P
V
P
M
N
K
E
L
V
A
T
L
T
-
E
L
C
E
R
E
K
L
N
------
Y
R
V
M
H
S
G
A
G
H
D
A
Q
I
F
A
-
P
R
V
P
T
C
M
I
F
I
P
S
I
N
G
I
S
H
N
P
A
E
R
T
N
I
T
D
L
A
E
G
V
K
T
L
A
L
M
L
Y
Q
L
A
-
25
PsiBlast_CBE
77.65
33%
-68
- C1 -
4WJB
8
?
B:
[28-399]
---------------
L
E
R
M
A
Q
I
G
A
T
P
K
G
G
V
C
R
L
A
L
T
D
L
D
R
E
S
R
D
L
F
V
Q
W
A
R
E
A
G
C
T
V
R
V
D
R
M
G
N
V
F
A
R
R
A
G
R
-
R
-
P
D
A
A
P
V
M
T
G
S
H
A
D
S
Q
P
T
G
-
G
-
R
Y
D
G
I
Y
G
V
L
G
G
L
E
V
V
R
A
L
N
D
A
A
I
E
T
E
-
R
P
V
D
V
V
I
W
T
N
E
E
G
S
R
F
A
P
A
M
V
S
A
G
V
F
S
G
V
--
Y
T
------
L
------
E
Y
G
---
L
S
--
R
T
D
G
A
G
R
T
I
G
E
E
L
E
R
--
I
G
--
Y
A
--
G
-------
A
E
--
P
V
-
G
--
G
Y
----
P
--
V
H
A
A
Y
E
L
H
I
E
Q
G
A
I
L
E
R
A
G
K
T
I
G
V
V
T
A
G
Q
G
Q
R
W
Y
E
V
T
L
T
G
V
D
A
H
A
G
T
T
--
P
M
A
F
-
R
R
D
---
A
L
V
G
A
A
R
M
I
---
S
F
V
E
V
L
G
--
R
R
Y
----
A
-----
P
D
A
R
A
T
V
G
M
I
E
A
-
R
P
N
S
R
N
T
V
P
G
G
C
F
F
T
V
E
F
R
H
P
D
D
A
V
L
D
E
L
D
A
A
L
R
A
E
L
A
R
V
A
D
--
E
T
G
L
G
A
Q
-
I
E
Q
I
F
T
Y
A
P
V
P
F
A
P
R
C
I
D
T
V
R
-
D
A
A
R
S
L
G
L
S
------
H
M
D
I
V
S
G
A
G
H
D
A
C
Y
V
A
-
R
V
A
P
T
G
M
I
F
V
P
C
V
--
L
S
H
N
E
A
E
-----------------------
24
PsiBlast_CBE
76.68
33%
-68
- C1 -
4WJB
7
?
C:
[28-399]
---------------
L
E
R
M
A
Q
I
G
A
T
P
K
G
G
V
C
R
L
A
L
T
D
L
D
R
E
S
R
D
L
F
V
Q
W
A
R
E
A
G
C
T
V
R
V
D
R
M
G
N
V
F
A
R
R
A
G
R
-
R
-
P
D
A
A
P
V
M
T
G
S
H
A
D
S
Q
P
T
G
-
G
-
R
Y
D
G
I
Y
G
V
L
G
G
L
E
V
V
R
A
L
N
D
A
A
I
E
T
E
-
R
P
V
D
V
V
I
W
T
N
E
E
G
S
R
F
A
P
A
M
V
S
A
G
V
F
S
G
V
--
Y
T
------
L
------
E
Y
G
---
L
S
--
R
T
D
G
A
G
R
T
I
G
E
E
L
E
R
--
I
G
--
Y
A
--
G
-------
A
E
--
P
V
-
G
--
G
Y
----
P
--
V
H
A
A
Y
E
L
H
I
E
Q
G
A
I
L
E
R
A
G
K
T
I
G
V
V
T
A
G
Q
G
Q
R
W
Y
E
V
T
L
T
G
V
D
A
H
A
G
T
T
--
P
M
A
F
-
R
R
D
---
A
L
V
G
A
A
R
M
I
---
S
F
V
E
V
L
G
--
R
R
Y
----
A
-----
P
D
A
R
A
T
V
G
M
I
E
A
-
R
P
N
S
R
N
T
V
P
G
G
C
F
F
T
V
E
F
R
H
P
D
D
A
V
L
D
E
L
D
A
A
L
R
A
E
L
A
R
V
A
D
--
E
T
G
L
G
A
Q
-
I
E
Q
I
F
T
Y
A
P
V
P
F
A
P
R
C
I
D
T
V
R
-
D
A
A
R
S
L
G
L
S
------
H
M
D
I
V
S
G
A
G
H
D
A
C
Y
V
A
-
R
V
A
P
T
G
M
I
F
V
P
C
V
--
L
S
H
N
E
A
E
-----------------------
5
PsiBlast_PDB
76.09
33%
-68
- C1 -
4WJB
7
?
A:
[28-399]
---------------
L
E
R
M
A
Q
I
G
A
T
P
K
G
G
V
C
R
L
A
L
T
D
L
D
R
E
S
R
D
L
F
V
Q
W
A
R
E
A
G
C
T
V
R
V
D
R
M
G
N
V
F
A
R
R
A
G
R
-
R
-
P
D
A
A
P
V
M
T
G
S
H
A
D
S
Q
P
T
G
-
G
-
R
Y
D
G
I
Y
G
V
L
G
G
L
E
V
V
R
A
L
N
D
A
A
I
E
T
E
-
R
P
V
D
V
V
I
W
T
N
E
E
G
S
R
F
A
P
A
M
V
S
A
G
V
F
S
G
V
--
Y
T
------
L
------
E
Y
G
---
L
S
--
R
T
D
G
A
G
R
T
I
G
E
E
L
E
R
--
I
G
--
Y
A
--
G
-------
A
E
--
P
V
-
G
--
G
Y
----
P
--
V
H
A
A
Y
E
L
H
I
E
Q
G
A
I
L
E
R
A
G
K
T
I
G
V
V
T
A
G
Q
G
Q
R
W
Y
E
V
T
L
T
G
V
D
A
H
A
G
T
T
--
P
M
A
F
-
R
R
D
---
A
L
V
G
A
A
R
M
I
---
S
F
V
E
V
L
G
--
R
R
Y
----
A
-----
P
D
A
R
A
T
V
G
M
I
E
A
-
R
P
N
S
R
N
T
V
P
G
G
C
F
F
T
V
E
F
R
H
P
D
D
A
V
L
D
E
L
D
A
A
L
R
A
E
L
A
R
V
A
D
--
E
T
G
L
G
A
Q
-
I
E
Q
I
F
T
Y
A
P
V
P
F
A
P
R
C
I
D
T
V
R
-
D
A
A
R
S
L
G
L
S
------
H
M
D
I
V
S
G
A
G
H
D
A
C
Y
V
A
-
R
V
A
P
T
G
M
I
F
V
P
C
V
D
G
L
S
H
N
E
A
E
-----------------------
26
PsiBlast_CBE
75.07
33%
-40
- C1 -
5I4M
4
?
B:
[34-421]
-------------
D
S
L
M
E
V
A
K
I
G
A
T
P
K
G
G
V
C
R
L
A
L
T
D
L
D
K
A
A
R
D
L
I
V
G
W
A
K
A
A
G
C
T
V
T
V
D
T
M
G
N
V
F
M
R
R
A
G
R
-
V
-
A
D
A
A
P
V
V
T
G
S
H
A
D
S
Q
P
T
G
-
G
-
R
F
D
G
I
Y
G
V
L
G
G
L
E
V
I
R
S
L
N
D
H
G
I
E
T
E
-
H
P
V
E
V
V
I
W
T
N
E
E
G
S
R
F
A
P
A
M
V
A
S
G
V
F
A
G
V
--
F
P
------
L
------
E
Y
G
---
L
S
--
R
K
D
V
D
G
K
T
I
G
E
E
L
A
R
--
I
G
--
Y
A
----------
G
D
--
A
P
-
C
--
G
G
R
--
K
L
--
H
A
A
F
-
E
L
H
I
E
Q
G
P
I
L
E
A
E
-
K
T
I
G
V
V
T
D
A
Q
G
Q
R
W
Y
E
I
T
F
T
G
Q
E
A
H
A
G
P
T
--
P
M
P
R
-
R
R
D
---
A
L
L
G
A
S
R
V
V
----
D
L
V
N
R
I
G
L
D
H
A
----
P
-----
Y
G
C
-
A
T
V
G
M
M
Q
V
-
H
P
N
S
R
N
V
I
P
G
R
V
F
F
T
V
D
F
R
H
P
D
D
A
V
L
A
K
M
D
A
A
L
R
D
G
V
A
R
I
A
A
--
D
I
G
L
D
T
A
-
L
E
Q
I
F
Y
Y
A
P
I
A
F
D
S
A
C
V
A
A
V
R
-
A
A
A
D
R
F
G
Y
S
------
H
R
D
I
V
S
G
A
G
H
D
A
C
Y
L
A
-
Q
V
A
P
T
S
M
V
F
V
P
C
I
D
G
I
S
H
N
E
I
E
D
A
T
P
A
W
I
E
A
G
A
N
V
L
---------
23
PsiBlast_CBE
74.89
34%
-24
- C1 -
3N5F
4
AMAB2_GEOSE
B:
[14-406]
------------------
L
G
E
V
G
K
Q
P
S
G
G
V
T
R
L
S
F
T
A
E
E
R
R
A
K
D
L
V
A
S
Y
M
R
E
A
G
L
F
V
Y
E
D
A
A
G
N
L
I
G
R
K
E
G
T
-
N
-
P
D
A
T
V
V
L
V
G
S
H
L
D
S
V
Y
N
G
-
G
-
C
F
D
G
P
L
G
V
L
A
G
V
E
V
V
Q
T
M
N
E
H
G
V
V
T
H
-
H
P
I
E
V
V
A
F
T
D
E
E
G
A
R
F
R
F
G
M
I
G
S
R
A
M
A
G
T
--
L
P
-------------
P
E
A
---
L
E
--
C
R
D
A
E
G
I
S
L
A
E
A
M
K
Q
--
A
G
--
L
D
--
P
-------
D
R
--
L
P
-
Q
--
A
A
R
--
K
P
GT
V
K
A
Y
V
E
L
H
I
E
Q
G
R
V
L
E
E
T
G
L
P
V
G
I
V
T
G
I
A
G
L
I
W
V
K
F
T
I
E
G
K
A
E
H
A
G
A
T
--
P
M
S
L
-
R
R
D
---
P
M
A
A
A
A
Q
I
I
---
I
V
I
E
E
E
A
--
R
R
T
----
G
-----
T
T
V
G
-
T
V
G
Q
L
H
V
-
Y
P
G
G
I
N
V
I
P
E
R
V
E
F
V
L
D
L
R
D
L
K
A
E
V
R
D
Q
V
W
K
A
I
A
V
R
A
E
T
I
A
K
--
E
R
N
V
R
V
T
-
T
E
R
L
Q
E
M
P
P
V
L
C
S
D
E
V
K
R
A
A
E
-
A
A
C
Q
K
L
G
Y
P
------
S
F
W
L
P
S
G
A
A
H
D
S
V
Q
L
A
-
P
I
C
P
I
G
M
I
F
V
R
S
Q
D
G
V
S
H
S
P
A
E
W
S
T
K
E
D
C
A
A
G
A
E
V
L
Y
H
T
V
W
Q
L
A
-
6
PsiBlast_PDB
74.83
33%
-41
- C1 -
5I4M
4
?
A:
[34-421]
-------------
D
S
L
M
E
V
A
K
I
G
A
T
P
K
G
G
V
C
R
L
A
L
T
D
L
D
K
A
A
R
D
L
I
V
G
W
A
K
A
A
G
C
T
V
T
V
D
T
M
G
N
V
F
M
R
R
A
G
R
-
V
-
A
D
A
A
P
V
V
T
G
S
H
A
D
S
Q
P
T
G
-
G
-
R
F
D
G
I
Y
G
V
L
G
G
L
E
V
I
R
S
L
N
D
H
G
I
E
T
E
-
H
P
V
E
V
V
I
W
T
N
E
E
G
S
R
F
A
P
A
M
V
A
S
G
V
F
A
G
V
--
F
P
------
L
------
E
Y
G
---
L
S
--
R
K
D
V
D
G
K
T
I
G
E
E
L
A
R
--
I
G
--
Y
A
----------
G
D
--
A
P
-
C
--
G
G
R
--
K
L
--
H
A
A
F
-
E
L
H
I
E
Q
G
P
I
L
E
A
E
-
K
T
I
G
V
V
T
D
A
Q
G
Q
R
W
Y
E
I
T
F
T
G
Q
E
A
H
A
G
P
T
--
P
M
P
R
-
R
R
D
---
A
L
L
G
A
S
R
V
V
----
D
L
V
N
R
I
G
L
D
H
A
----
P
-----
Y
G
C
-
A
T
V
G
M
M
Q
V
-
H
P
N
S
R
N
V
I
P
G
R
V
F
F
T
V
D
F
R
H
P
D
D
A
V
L
A
K
M
D
A
A
L
R
D
G
V
A
R
I
A
A
--
D
I
G
L
D
T
A
-
L
E
Q
I
F
Y
Y
A
P
I
A
F
D
S
A
C
V
A
A
V
R
-
A
A
A
D
R
F
G
Y
S
------
H
R
D
I
V
S
G
A
G
H
D
A
C
Y
L
A
-
Q
V
A
P
T
S
M
V
F
V
P
C
I
D
G
I
S
H
N
E
I
E
D
A
T
P
A
W
I
E
A
G
A
N
V
L
---------
57
HHSearch
71.47
33%
1
- C1 -
4WJB
7
?
A:
[18-421]
-----
R
V
D
G
D
R
L
W
A
S
L
E
R
M
A
Q
I
G
A
T
P
K
G
G
V
C
R
L
A
L
T
D
L
D
R
E
S
R
D
L
F
V
Q
W
A
R
E
A
G
C
T
V
R
V
D
R
M
G
N
V
F
A
R
R
A
G
R
R
P
-
D
A
-
A
P
V
M
T
G
S
H
A
D
S
Q
P
T
G
-
G
-
R
Y
D
G
I
Y
G
V
L
G
G
L
E
V
V
R
A
L
N
D
A
-
A
I
E
T
E
R
P
V
D
V
V
I
W
T
N
E
E
G
S
R
------
F
A
P
A
M
V
S
A
--
G
V
F
S
GVYT
L
------
E
Y
G
---
L
S
--
R
T
D
G
A
G
R
T
I
G
E
E
L
E
R
--
I
G
YA
G
A
--
E
-------
P
V
---------
G
G
--
Y
P
--
V
H
A
A
Y
E
L
H
I
E
Q
G
A
I
L
E
R
A
G
K
T
I
G
V
V
T
A
G
Q
G
Q
R
W
Y
E
V
T
L
T
G
V
D
A
H
A
G
T
T
--
P
M
A
F
-
R
R
D
---
A
L
V
G
A
A
R
M
I
---
S
F
V
------
E
V
L
G
R
R
Y
A
-----
P
D
A
R
A
T
V
G
M
I
E
A
-
R
P
N
S
R
N
T
V
P
G
G
C
F
F
T
V
E
F
R
H
P
D
D
A
V
L
D
E
L
D
A
A
L
R
A
E
L
A
R
V
A
D
--
E
T
G
L
G
A
Q
-
I
E
Q
I
F
T
Y
A
P
V
P
F
A
P
R
C
I
D
T
V
R
-
D
A
A
R
S
L
G
L
S
------
H
M
D
I
V
S
G
A
G
H
D
A
C
Y
V
A
-
R
V
A
P
T
G
M
I
F
V
P
C
V
D
G
L
S
H
N
E
A
E
A
I
T
P
E
W
A
T
A
G
A
D
V
L
L
R
A
V
L
Q
S
A
-
56
HHSearch
71.24
35%
-3
- C1 -
3N5F
3
AMAB2_GEOSE
A:
[3-406]
-------
Q
G
E
R
L
W
Q
R
L
M
E
L
G
E
V
G
K
Q
P
S
G
G
V
T
R
L
S
F
T
A
E
E
R
R
A
K
D
L
V
A
S
Y
M
R
E
A
G
L
F
V
Y
E
D
A
A
G
N
L
I
G
R
K
E
G
T
-
N
P
D
A
-
T
V
V
L
V
G
S
H
L
D
S
V
Y
N
G
-
G
-
C
F
D
G
P
L
G
V
L
A
G
V
E
V
V
Q
T
M
N
E
H
-
G
V
V
T
H
H
P
I
E
V
V
A
F
T
D
E
E
G
A
R
F
R
F
G
M
I
G
S
R
A
M
A
G
T
--
L
P
-------------
P
E
A
---
L
E
--
C
R
D
A
E
G
I
S
L
A
E
A
M
K
Q
--
A
G
---
L
--
D
-------
P
D
RL
P
Q
A
A
--
R
K
P
--
G
T
--
V
K
A
Y
V
E
L
H
I
E
Q
G
R
V
L
E
E
T
G
L
P
V
G
I
V
T
G
I
A
G
L
I
W
V
K
F
T
I
E
G
K
A
E
H
A
G
A
T
--
P
M
S
L
-
R
R
D
---
P
M
A
A
A
A
Q
I
I
---
I
V
I
------
E
E
E
A
R
R
-
T
-----
G
T
T
V
G
T
V
G
Q
L
H
V
-
Y
P
G
G
I
N
V
I
P
E
R
V
E
F
V
L
D
L
R
D
L
K
A
E
V
R
D
Q
V
W
K
A
I
A
V
R
A
E
T
I
A
K
--
E
R
N
V
R
V
T
-
T
E
R
L
Q
E
M
P
P
V
L
C
S
D
E
V
K
R
A
A
E
-
A
A
C
Q
K
L
G
Y
P
------
S
F
W
L
P
S
G
A
A
H
D
S
V
Q
L
A
-
P
I
C
P
I
G
M
I
F
V
R
S
Q
D
G
V
S
H
S
P
A
E
W
S
T
K
E
D
C
A
A
G
A
E
V
L
Y
H
T
V
W
Q
L
A
-
9
PsiBlast_PDB
71.06
30%
5
- C1 -
4PXC
4
UAH_ARATH
A:
[20-428]
-----------
L
Q
N
Q
I
D
E
L
S
S
F
S
D
A
P
S
P
S
V
T
R
V
L
Y
T
D
K
D
V
S
A
R
R
Y
V
K
N
L
M
A
L
A
G
L
T
V
R
E
D
A
V
G
N
I
F
G
K
W
D
G
L
-
E
-
P
N
L
P
A
V
A
T
G
S
H
I
D
A
I
P
Y
S
-
G
-
K
Y
D
G
V
V
G
V
L
G
A
I
E
A
I
N
V
L
K
R
S
G
F
K
P
K
-
R
S
L
E
I
I
L
F
T
S
A
E
P
T
R
F
G
I
S
C
L
G
S
R
L
L
A
G
S
K
E
L
A
------
E
------
A
L
K
---
T
T
--
V
V
D
G
Q
N
V
S
F
I
E
A
A
R
S
--
A
G
--
Y
A
--
E
DKDDDLS
S
V
--
F
L
-
K
----
K
--
G
S
--
Y
F
A
F
L
E
L
H
I
E
Q
G
P
I
L
E
D
E
G
L
D
I
G
V
V
T
A
I
A
A
P
A
S
L
K
V
E
F
E
G
N
G
G
H
A
G
A
V
--
L
M
P
Y
-
R
N
D
A
G
L
A
A
A
E
L
A
L
A
V
---
E
K
H
V
L
E
S
--
E
S
I
-----------
D
T
V
G
T
V
G
I
L
E
L
-
H
P
G
A
I
N
S
I
P
S
K
S
H
L
E
I
D
T
R
D
I
D
E
A
R
R
N
T
V
I
K
K
I
Q
E
S
A
N
T
I
A
K
--
K
R
K
V
K
L
S
-
E
F
K
I
V
N
Q
D
P
P
A
L
S
D
K
L
V
I
K
K
M
A
E
A
A
T
E
L
N
L
S
------
H
K
M
M
I
S
R
A
Y
H
D
S
L
F
M
A
-
R
I
S
P
M
G
M
I
F
I
P
C
Y
K
G
Y
S
H
K
P
E
E
Y
S
S
P
E
D
M
A
N
G
V
K
V
L
S
L
T
L
A
K
L
S
-
4
PsiBlast_PDB
70.47
34%
-21
- C1 -
3N5F
3
AMAB2_GEOSE
A:
[14-406]
------------------
L
G
E
V
G
K
Q
P
S
G
G
V
T
R
L
S
F
T
A
E
E
R
R
A
K
D
L
V
A
S
Y
M
R
E
A
G
L
F
V
Y
E
D
A
A
G
N
L
I
G
R
K
E
G
T
-
N
-
P
D
A
T
V
V
L
V
G
S
H
L
D
S
V
Y
N
G
-
G
-
C
F
D
G
P
L
G
V
L
A
G
V
E
V
V
Q
T
M
N
E
H
G
V
V
T
H
-
H
P
I
E
V
V
A
F
T
D
E
E
G
A
R
F
R
F
G
M
I
G
S
R
A
M
A
G
T
--
L
P
-------------
P
E
A
---
L
E
--
C
R
D
A
E
G
I
S
L
A
E
A
M
K
Q
--
A
G
--
L
D
--
P
-------
D
R
--
L
P
-
Q
--
A
A
R
--
K
P
GT
V
K
A
Y
V
E
L
H
I
E
Q
G
R
V
L
E
E
T
G
L
P
V
G
I
V
T
G
I
A
G
L
I
W
V
K
F
T
I
E
G
K
A
E
H
A
G
A
T
--
P
M
S
L
-
R
R
D
---
P
M
A
A
A
A
Q
I
I
---
I
V
I
E
E
E
A
--
R
R
T
----
G
-----
T
T
V
G
-
T
V
G
Q
L
H
V
-
Y
P
G
G
I
N
V
I
P
E
R
V
E
F
V
L
D
L
R
D
L
K
A
E
V
R
D
Q
V
W
K
A
I
A
V
R
A
E
T
I
A
K
--
E
R
N
V
R
V
T
-
T
E
R
L
Q
E
M
P
P
V
L
C
S
D
E
V
K
R
A
A
E
-
A
A
C
Q
K
L
G
Y
P
------
S
F
W
L
P
S
G
A
A
H
D
S
V
Q
L
A
-
P
I
C
P
I
G
M
I
F
V
R
S
Q
D
G
V
S
H
S
P
A
E
W
S
T
K
E
D
C
A
A
G
A
E
V
L
Y
H
T
V
W
Q
L
A
-
8
PsiBlast_PDB
70.29
30%
5
- C1 -
4PXB
4
UAH_ARATH
A:
[20-428]
-----------
L
Q
N
Q
I
D
E
L
S
S
F
S
D
A
P
S
P
S
V
T
R
V
L
Y
T
D
K
D
V
S
A
R
R
Y
V
K
N
L
M
A
L
A
G
L
T
V
R
E
D
A
V
G
N
I
F
G
K
W
D
G
L
-
E
-
P
N
L
P
A
V
A
T
G
S
H
I
D
A
I
P
Y
S
-
G
-
K
Y
D
G
V
V
G
V
L
G
A
I
E
A
I
N
V
L
K
R
S
G
F
K
P
K
-
R
S
L
E
I
I
L
F
T
S
A
E
P
T
R
F
G
I
S
C
L
G
S
R
L
L
A
G
S
K
E
L
A
------
E
------
A
L
K
---
T
T
--
V
V
D
G
Q
N
V
S
F
I
E
A
A
R
S
--
A
G
--
Y
A
--
E
DKDDDLS
S
V
--
F
L
-
K
----
K
--
G
S
--
Y
F
A
F
L
E
L
H
I
E
Q
G
P
I
L
E
D
E
G
L
D
I
G
V
V
T
A
I
A
A
P
A
S
L
K
V
E
F
E
G
N
G
G
H
A
G
A
V
--
L
M
P
Y
-
R
N
D
A
G
L
A
A
A
E
L
A
L
A
V
---
E
K
H
V
L
E
S
--
E
S
I
-----------
D
T
V
G
T
V
G
I
L
E
L
-
H
P
G
A
I
N
S
I
P
S
K
S
H
L
E
I
D
T
R
D
I
D
E
A
R
R
N
T
V
I
K
K
I
Q
E
S
A
N
T
I
A
K
--
K
R
K
V
K
L
S
-
E
F
K
I
V
N
Q
D
P
P
A
L
S
D
K
L
V
I
K
K
M
A
E
A
A
T
E
L
N
L
S
------
H
K
M
M
I
S
R
A
Y
H
D
S
L
F
M
A
-
R
I
S
P
M
G
M
I
F
I
P
C
Y
K
G
Y
S
H
K
P
E
E
Y
S
S
P
E
D
M
A
N
G
V
K
V
L
S
L
T
L
A
K
L
S
-
3
PsiBlast_PDB
70.23
45%
-5
- C1 -
2IMO
-
ALLC_ECOLI
A:
[8-411]
--------
R
Q
A
I
E
E
T
L
P
W
L
S
S
F
G
A
D
----
M
T
R
L
L
Y
S
P
E
W
L
E
T
Q
Q
Q
F
K
K
R
M
A
A
S
G
L
E
T
R
F
D
E
V
G
N
L
Y
G
R
L
N
G
T
-
E
-
Y
P
Q
E
V
V
L
S
G
S
H
I
D
T
V
V
N
G
-
G
-
N
L
D
G
Q
F
G
A
L
A
A
W
L
A
I
D
W
L
K
T
Q
Y
G
A
P
L
-
R
T
V
E
V
V
A
M
A
E
E
E
G
S
R
F
P
Y
V
F
W
G
S
K
N
I
F
G
L
--
A
N
------
P
------
D
D
V
-------------
N
S
F
V
D
A
M
K
A
--
C
G
--
F
T
--
L
-------
P
N
--
A
P
-
L
--
T
P
R
--
Q
D
--
I
K
A
F
V
E
L
H
I
E
Q
G
C
V
L
E
S
N
G
Q
S
I
G
V
V
N
A
I
V
G
Q
R
R
Y
T
V
T
L
N
G
E
S
N
H
A
G
T
T
--
P
M
G
Y
-
R
R
D
---
T
V
Y
A
F
S
R
I
C
---
H
Q
S
V
E
K
A
--
K
R
M
----
G
-----
D
P
L
V
L
T
F
G
K
V
E
P
-
R
P
N
T
V
N
V
V
P
G
K
T
T
F
T
I
D
C
R
H
T
D
A
A
V
L
R
D
F
T
Q
Q
L
E
N
D
M
R
A
I
C
D
--
E
M
D
I
G
I
D
-
I
D
L
W
M
D
E
E
P
V
P
M
N
K
E
L
V
A
T
L
T
-
E
L
C
E
R
E
K
L
N
------
Y
R
V
M
H
S
G
A
G
H
D
A
Q
I
F
A
-
P
R
V
P
T
C
M
I
F
I
P
S
I
N
G
I
S
H
N
P
A
E
R
T
N
I
T
D
L
A
E
G
V
K
T
L
A
L
M
L
Y
Q
L
A
W
7
PsiBlast_PDB
69.71
31%
8
- C1 -
4PXE
4
UAH_ARATH
A:
[20-428]
-----------
L
Q
N
Q
I
D
E
L
S
S
F
S
D
A
P
S
P
S
V
T
R
V
L
Y
T
D
K
D
V
S
A
R
R
Y
V
K
N
L
M
A
L
A
G
L
T
V
R
E
D
A
V
G
N
I
F
G
K
W
D
G
L
-
E
-
P
N
L
P
A
V
A
T
G
S
H
I
D
A
I
P
Y
S
-
G
-
K
Y
D
G
V
V
G
V
L
G
A
I
E
A
I
N
V
L
K
R
S
G
F
K
P
K
-
R
S
L
E
I
I
L
F
T
S
E
E
P
T
R
F
G
I
S
C
L
G
S
R
L
L
A
G
S
K
E
L
A
------
E
------
A
L
K
---
T
T
--
V
V
D
G
Q
N
V
S
F
I
E
A
A
R
S
--
A
G
--
Y
A
--
E
DKDDDLS
S
V
--
F
L
-
K
----
K
--
G
S
--
Y
F
A
F
L
E
L
H
I
E
Q
G
P
I
L
E
D
E
G
L
D
I
G
V
V
T
A
I
A
A
P
A
S
L
K
V
E
F
E
G
N
G
G
H
A
G
A
V
--
L
M
P
Y
-
R
N
D
A
G
L
A
A
A
E
L
A
L
A
V
---
E
K
H
V
L
E
S
--
E
S
I
-----------
D
T
V
G
T
V
G
I
L
E
L
-
H
P
G
A
I
N
S
I
P
S
K
S
H
L
E
I
D
T
R
D
I
D
E
A
R
R
N
T
V
I
K
K
I
Q
E
S
A
N
T
I
A
K
--
K
R
K
V
K
L
S
-
E
F
K
I
V
N
Q
D
P
P
A
L
S
D
K
L
V
I
K
K
M
A
E
A
A
T
E
L
N
L
S
------
H
K
M
M
I
S
R
A
Y
H
D
S
L
F
M
A
-
R
I
S
P
M
G
M
I
F
I
P
C
Y
K
G
Y
S
H
K
P
E
E
Y
S
S
P
E
D
M
A
N
G
V
K
V
L
S
L
T
L
A
K
L
S
-
27
PsiBlast_CBE
69.66
31%
9
- C1 -
4PXE
4
UAH_ARATH
B:
[20-428]
-----------
L
Q
N
Q
I
D
E
L
S
S
F
S
D
A
P
S
P
S
V
T
R
V
L
Y
T
D
K
D
V
S
A
R
R
Y
V
K
N
L
M
A
L
A
G
L
T
V
R
E
D
A
V
G
N
I
F
G
K
W
D
G
L
-
E
-
P
N
L
P
A
V
A
T
G
S
H
I
D
A
I
P
Y
S
-
G
-
K
Y
D
G
V
V
G
V
L
G
A
I
E
A
I
N
V
L
K
R
S
G
F
K
P
K
-
R
S
L
E
I
I
L
F
T
S
E
E
P
T
R
F
G
I
S
C
L
G
S
R
L
L
A
G
S
KE
L
A
------
E
------
A
L
K
---
T
T
--
V
V
D
G
Q
N
V
S
F
I
E
A
A
R
S
--
A
G
--
Y
A
--
E
DKDDDLS
S
V
--
F
L
-
K
----
K
--
G
S
--
Y
F
A
F
L
E
L
H
I
E
Q
G
P
I
L
E
D
E
G
L
D
I
G
V
V
T
A
I
A
A
P
A
S
L
K
V
E
F
E
G
N
G
G
H
A
G
A
V
--
L
M
P
Y
-
R
N
D
AGL
A
A
A
E
L
A
L
A
V
---
E
K
H
V
L
E
S
--
E
S
I
-----------
D
T
V
G
T
V
G
I
L
E
L
-
H
P
G
A
I
N
S
I
P
S
K
S
H
L
E
I
D
T
R
D
I
D
E
A
R
R
N
T
V
I
K
K
I
Q
E
S
A
N
T
I
A
K
--
K
R
K
V
K
L
S
-
E
F
K
I
V
N
Q
D
P
P
A
L
S
D
K
L
V
I
K
K
M
A
E
A
A
T
E
L
N
L
S
------
H
K
M
M
I
S
R
A
Y
H
D
S
L
F
M
A
-
R
I
S
P
M
G
M
I
F
I
P
C
Y
K
G
Y
S
H
K
P
E
E
Y
S
S
P
E
D
M
A
N
G
V
K
V
L
S
L
T
L
A
K
L
S
-
60
HHSearch
68.15
30%
-5
- C1 -
5I4M
4
?
A:
[26-429]
-----
K
V
D
G
R
R
L
W
D
S
L
M
E
V
A
K
I
G
A
T
P
K
G
G
V
C
R
L
A
L
T
D
L
D
K
A
A
R
D
L
I
V
G
W
A
K
A
A
G
C
T
V
T
V
D
T
M
G
N
V
F
M
R
R
A
G
R
V
A
-
D
A
-
A
P
V
V
T
G
S
H
A
D
S
Q
P
T
G
G
R
-
F
-
D
G
I
Y
G
V
L
G
G
L
E
V
I
R
S
L
N
D
H
-
G
I
E
T
E
H
P
V
E
V
V
I
W
T
N
E
E
G
S
R
-----
F
A
P
-
A
M
V
A
S
--
G
V
------
F
A
GVFP
L
E
Y
G
---
L
S
--
R
K
D
V
D
G
K
T
I
G
E
E
L
A
R
I
G
Y
A
--
G
D
--
A
-------
P
C
--------
G
G
---
R
K
--
L
H
A
A
F
E
L
H
I
E
Q
G
P
I
L
E
A
E
-
K
T
I
G
V
V
T
D
A
Q
G
Q
R
W
Y
E
I
T
F
T
G
Q
E
A
H
A
G
P
T
--
P
M
P
R
-
R
R
D
---
A
L
L
G
A
S
R
V
V
---
D
L
V
------
N
R
I
G
L
D
H
A
-----
P
Y
G
C
A
T
V
G
M
M
Q
V
H
P
-
N
S
R
N
V
I
P
G
R
V
F
F
T
V
D
F
R
H
P
D
D
A
V
L
A
K
M
D
A
A
L
R
D
G
V
A
R
I
A
A
--
D
I
G
L
D
T
A
-
L
E
Q
I
F
Y
Y
A
P
I
A
F
D
S
A
C
V
A
A
V
R
-
A
A
A
D
R
F
G
Y
S
------
H
R
D
I
V
S
G
A
G
H
D
A
C
Y
L
A
Q
V
A
P
T
S
-
M
V
F
V
P
C
I
D
G
I
S
H
N
E
I
E
D
A
T
P
A
W
I
E
A
G
A
N
V
L
L
H
A
M
L
S
R
A
-
64
HHSearch
64.46
30%
16
- C1 -
4PXE
4
UAH_ARATH
A:
[23-428]
-----------
Q
I
D
E
L
S
S
F
S
D
A
P
S
P
S
---
V
T
R
V
L
Y
T
D
K
D
V
S
A
R
R
Y
V
K
N
L
M
A
L
A
G
L
T
V
R
E
D
A
V
G
N
I
F
G
K
W
D
G
L
E
P
-
N
L
-
P
A
V
A
T
G
S
H
I
D
A
I
P
Y
S
-
G
-
K
Y
D
G
V
V
G
V
L
G
A
I
E
A
I
N
V
L
K
R
S
-
G
F
K
P
K
R
S
L
E
I
I
L
F
T
S
E
E
P
T
R
F
G
I
S
C
L
G
S
R
L
L
A
G
S
--
K
E
L
-----
A
------
E
A
----
L
K
T
T
V
V
D
G
Q
N
V
S
F
I
E
A
A
R
S
--
A
G
--
Y
A
--
E
-------
D
K
D-
D
D
-
L
SS
V
F
L
KK
G
S
--
Y
F
A
F
L
E
L
H
I
E
Q
G
P
I
L
E
D
E
G
L
D
I
G
V
V
T
A
I
A
A
P
A
S
L
K
V
E
F
E
G
N
G
G
H
A
G
A
V
LM
P
Y
-
R
--
N
D
---
A
G
L
A
A
A
E
L
A
---
L
A
V
------
E
K
H
----
V
L
E
SES
I
D
T
V
G
T
V
G
I
L
E
L
H
P
-
G
A
I
N
S
I
P
S
K
S
H
L
E
I
D
T
R
D
I
D
E
A
R
R
N
T
V
I
K
K
I
Q
E
S
A
N
T
I
A
K
--
K
R
K
V
K
L
S
E
F
K
I
V
N
Q
D
P
P
A
L
S
D
K
L
V
I
K
K
M
A
-
E
A
A
T
E
L
N
L
S
------
H
K
M
M
I
S
R
A
Y
H
D
S
L
F
M
A
R
I
S
P
M
G
-
M
I
F
I
P
C
Y
K
G
Y
S
H
K
P
E
E
Y
S
S
P
E
D
M
A
N
G
V
K
V
L
S
L
T
L
A
K
L
S
-
16
PsiBlast_PDB
58.44
30%
-1
- C1 -
1R43
5
?
A:
[79-439]
-----------------------------------------------
N
E
C
E
S
L
G
C
K
V
K
V
D
K
I
G
N
M
F
A
V
Y
P
G
--
K
-
N
G
G
K
P
T
A
T
G
S
H
L
D
T
Q
P
E
A
-
G
-
K
Y
D
G
I
L
G
V
L
A
G
L
E
V
L
R
T
F
K
D
N
N
Y
V
P
N
-
Y
D
V
C
V
V
V
W
F
N
E
E
G
A
R
F
A
R
S
C
T
G
S
S
V
W
S
H
D
--
L
S
------
L
------
E
E
A
Y
G
L
M
S
--
V
G
E
D
K
P
E
S
V
Y
D
S
L
K
N
--
I
G
--
Y
I
--
G
-------
D
T
--
P
A
-
S
--
Y
K
E
--
N
E
--
I
D
A
H
F
E
L
H
I
E
Q
G
P
I
L
E
D
E
N
K
A
I
G
I
V
T
G
V
Q
A
Y
N
W
Q
K
V
T
V
H
G
V
G
A
H
A
G
T
T
--
P
W
R
L
-
R
K
D
---
A
L
L
M
S
S
K
M
I
V
A
A
S
E
I
A
Q
R
H
--
N
G
L
--------------
F
T
C
G
I
I
D
A
-
K
P
Y
S
V
N
I
I
P
G
E
V
S
F
T
L
D
F
R
H
P
S
D
D
V
L
A
T
M
L
K
E
A
A
A
E
F
D
R
L
I
K
IN
D
G
G
A
L
S
Y
-
E
S
E
T
L
Q
V
S
P
A
---
V
N
F
H
E
V
C
I
-
E
C
V
S
R
S
A
F
A
Q
F
KKDQ
V
R
Q
I
W
S
G
A
G
H
D
S
C
Q
T
A
-
P
H
V
P
T
S
M
I
F
I
P
S
K
D
G
L
S
H
N
Y
Y
E
Y
S
S
P
E
E
I
E
N
G
F
K
V
L
---------