@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu32600: (2016-07-24 )
MKKMLLFLIIAAVSMLTIAGCSSQSSSADGKVTLKFFHRWPKEPEKSYFEEVVKEFEKDHPDIDIQIEAVLNDSYKDKIKVMLGTTSPPDIYFSWSDEFAFKFIRGNKALDLSSYYKNDTDWSSQLVQSQITPFTYENKQYGVPWQMDAKSFFYNKDIFQKLNLDPPKTWDELIDVSKKLKEHGYTPISFGTKATWTISHYIGTLNQRMVDEKTREKDYNAKTGEFTDEGYVKALEKLQELMPYFNKHVNSVDHEYVRQQFKSGKSAMIYAETAEIKLVEPVNLGMFPFPEISGQKGSSEALTGAPEGFMISSRTKHPKEAMEFLQFLTSKRMGEKLVKDVGKYSAVQGTATEENATAIQREAVQHIVDAKSMVPWFDMDVDVEVADAYLTGVQQMLGGDMTPQQVMKAVQKAAKQVRASAE
Atome Classification :
(20 SA)
.........10........20........30........40........50.......----.60........70-.---.......80.....-....90...----...-..100.......110.......120-.......130..-.....140....-..-.150.......160..---.---.---...170.......180.--.--.-..-----..190.....--..200.......210-........220.......230.......240-.------.......250----..--..-...260.......270.--...-...----280-----.-------------...-----....-----------.290....-.-------.-.-300........310...--.....320.......330.......340.....-...350.--.-.----.------.------.------.---360.-.-....-.----370....-...380.......390.......400.......410.......420-----------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
K
M
L
L
F
L
I
I
A
A
V
S
M
L
T
IAGCSSQSSSAD
G
K
V
T
L
K
F
F
H
RWPKEP
E
K
S
Y
F
E
E
V
V
K
E
F
E
K----DHPD
I
D
I
Q
I
E
A
V
L-N---DSYK
D
K
I
K
-
V
M
L
GT-TSPP
D
I
Y
F
S----WS
D
-
E
F
A
F
K
F
IRGNKAL
D
L
S
S
YYKNDT
D
W
-
S
S
Q
L
V
Q
S
QITP
F
-
T
YENKQYGVPWQ-M
D
-
A
K
S
FFY
N
K
D
I
F
Q
KLNL---D---P---PK
T
W
D
E
L
I
D
V
S
K
K
L
K
EH--G--Y-TP-----ISFGT
K
A
T
W
T
--
I
S
H
Y
I
G
T
L
N
Q
R
M
V
D
--
E
K
TREKDYNAKTGEFT
D
E
G
Y
V
K
A
L
E
K
L
Q
E
L
--
M
------
P
Y
F
N
K
H
VNSV----
D
H
--
E
Y
-
V
R
Q
Q
F
KSGK
S
A
M
I
Y
A
ET--A
E
I
-
K
L
V
----
E
-------P-------------VNL-----GMFP-----------FPEISGQK-G-------S-S-E-ALTGAPE
G
F
M
-ISSR--TKH
P
K
E
A
M
E
F
L
Q
F
L
T
S
K
R
M
G
E
K
L
V
K
D
-
V
G
K
Y
SA-VQGTATE--E-
N
----
A
------
T
------
A
------
I
---
Q
R
E
A
-
V
-
Q
H
I
V
-
D
----
A
K
SMVPW-FDMDV
D
V
E
V
A
D
A
Y
L
T
G
V
Q
Q
M
LGGDM
T
P
Q
Q
V
M
K
A
V
Q
K
A
A
K
Q
V
RASAE-----------------------------------------------------------------------------------------------------------
24
HHSearch
86.22
26%
0
* C1 *
4G68
1
?
A:
[63-454]
-------------------------------
I
T
L
T
F
W
N
L
F
T
G
E
P
A
K
T
K
V
K
E
I
I
D
Q
W
N
K
----
E
N
P
N
V
Q
I
V
E
S
V
T
E
-
N
---
D
A
Y
K
T
K
I
K
-
A
A
I
A
A
-
N
E
A
P
D
I
F
Q
T
----
W
A
G
-
G
F
S
Q
P
F
V
E
A
G
K
V
L
Q
L
D
S
Y
L
N
D
G
--
T
-
K
D
Q
L
L
P
G
S
F
D
N
V
-
T
Y
N
G
K
I
Y
G
I
P
F
D
-
Q
Q
-
A
S
V
L
Y
I
N
K
E
L
F
D
K
Y
N
V
---
K
---
V
---
P
T
T
F
S
E
L
I
D
A
I
K
T
F
K
S
K
--
G
--
V
-
T
P
-----
F
A
L
G
E
K
D
E
W
P
--
G
M
W
Y
Y
D
M
I
A
L
R
E
G
G
--
V
Q
L
T
R
D
A
L
N
G
K
-
A
S
F
D
N
Q
A
F
T
D
A
A
Q
K
L
Q
D
M
--
V
N
A
----
G
A
F
D
S
G
F
M
G
L
----
T
R
--
D
E
-
A
T
A
E
F
N
Q
G
K
A
A
M
Y
F
G
G
N
--
F
D
A
A
A
F
V
----
S
DPSSLV-
K
-------------
G
K
I
-----
E
A
V
R
-----------
F
P
T
I
E
G
G
K
-
G
-------
D
-
P
-
T
E
Y
I
G
G
T
V
G
A
L
M
-
V
S
A
N
--
S
K
Y
K
D
E
A
V
R
A
A
K
Y
L
A
K
Q
L
S
D
M
D
Y
L
I
A
--
T
G
L
P
A
-
W
K
Y
D
N
I
D
Q-
S
-
K
----
V
------
D
------
P
------
L
---
E
I
Q
I
M
N
-
N
I
V
A
-
N
----
A
K
G
S
V
P
A
-
W
D
I
Y
L
S
G
D
A
A
Q
T
H
K
D
L
V
A
Q
L
F
A
K
Q
I
T
P
E
E
Y
S
K
Q
M
Q
Q
K
I
N
------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
83.03
26%
7
- C1 -
4G68
-
?
C:
[39-427]
-------------------------------
I
T
L
T
F
W
N
L
F
T
G
E
P
A
K
T
K
V
K
E
I
I
D
Q
W
N
K
----
E
N
P
N
V
Q
I
V
E
S
V
T
E
-
N
---
D
A
Y
K
T
K
I
K
-
A
A
I
A
A
-
N
E
A
P
D
I
F
Q
T
----
W
A
G
-
G
F
S
Q
P
F
V
E
A
G
K
V
L
Q
L
D
S
Y
L
N
D
G
T
---
K
D
Q
L
L
P
G
S
F
D
N
V
-
T
Y
N
G
K
I
Y
G
I
P
F
D
-
Q
Q
-
A
S
V
L
Y
I
N
K
E
L
F
D
K
Y
N
V
---
K
---
V
---
P
T
T
F
S
E
L
I
D
A
I
K
T
F
K
S
K
--
G
--
V
-
T
P
-----
F
A
L
G
E
K
D
E
W
P
--
G
M
W
Y
Y
D
M
I
A
L
R
E
G
G
--
V
Q
L
T
R
D
A
L
N
G
K
A
-
S
F
D
N
Q
A
F
T
D
A
A
Q
K
L
Q
D
M
--
V
NA----
G
A
F
D
S
G
F
M
G
L
----
T
R
--
D
E
-
A
T
A
E
F
N
Q
G
K
A
A
M
Y
F
G
G
N
FD
A
A
A
-
F
V
S
----
D
-------
P
-------------
S
S
L
VKGKI
E
A
V
R
-----------
F
P
T
I
E
G
G
K
-
G
-------
D
P
T
-
E
-
Y
I
G
G
T
V
G
A
L
M
-
V
S
A
N
--
S
K
Y
K
D
E
A
V
R
A
A
K
Y
L
A
K
Q
L
S
D
M
D
Y
L
I
A
-
T
G
L
P
A
W
-
K
Y
D
N
I
D
Q
--
S
-
K
----
V
------
D
------
P
------
L
---
E
I
Q
I
-
M
-
N
N
I
V
A
N
----
A
K
G
S
V
P
A
-
W
D
I
Y
L
S
G
D
A
A
Q
T
H
K
D
L
V
A
Q
L
F
A
K
Q
I
T
P
E
E
Y
S
K
Q
M
Q
Q
---------------------------------------------------------------------------------------------------------------------
21
HHSearch
79.68
25%
27
- C1 -
4C1U
5
?
A:
[18-412]
-----------------------------
D
D
K
T
I
T
F
W
H
N
A
S
A
G
E
G
R
Q
Y
W
E
N
L
A
K
S
F
E
E
----
A
N
P
G
T
K
V
E
I
Q
A
I
Q
-
N
---
E
D
F
A
G
K
L
Q
-
T
A
M
Q
D
P
A
S
G
P
D
V
F
M
S
----
L
G
G
-
A
K
T
K
E
M
I
D
A
G
Q
V
M
D
L
T
D
K
I
S
D
T
--
V
-
K
T
D
-
M
K
T
T
L
S
A
A
-
T
F
D
G
K
V
Y
G
V
P
V
S
-
V
E
-
P
G
G
M
W
Y
S
K
D
L
F
K
K
A
G
V
---
S
D--
V
---
P
A
T
Y
E
E
L
L
A
D
A
K
K
L
K
D
S
--
G
--
T
-
D
A
-----
I
A
L
G
A
K
D
A
W
P
--
A
A
H
W
Y
Y
W
L
V
L
R
E
C
S
--
P
E
V
Y
D
K
S
V
-
Q
D
-
H
D
F
S
N
A
C
W
V
N
A
G
K
K
L
Q
E
L
--
K
D
L
----
K
V
F
N
D
G
F
L
T
T
TAQQ
G
A
--
N
S
-
S
A
G
L
L
A
N
H
K
A
A
M
E
L
M
G
A
--
W
E
P
G
V
L
K
----
D
L
TPDQKP
M
-------------
A
D
L
-----
G
F
F
A
-----------
F
P
E
V
A
G
G
E
G
E
-------
P
-
G
-
A
-
L
M
G
G
-
V
T
Y
F
C
-
V
N
P
----
K
A
S
Q
T
S
I
D
F
V
N
Y
M
G
E
K
K
N
Q
E
D
Y
A
K
A
-
F
S
T
I
P
A
-
S
E
P
A
R
A
V
--
V
------
T
------
D
------
E
------
S
---
L
K
Q
V
-
I
-
E
Y
L
D
-
K
----
A
P
S
M
Q
L
W
-
M
D
T
A
L
G
T
N
I
G
N
A
L
N
A
A
V
V
N
M
L
S
G
Q
G
S
P
E
D
I
V
K
A
M
Q
D
A
A
Q
K
-----------------------------------------------------------------------------------------------------------------
42
Fugue
75.49
18%
-42
- C1 -
3OO8
8
?
A:
[26-415]
-----------------------------
G
N
G
P
I
T
F
G
S
N
Y
S
D
E
A
P
K
A
A
F
A
S
L
M
Q
Q
A
T
T
-----
S
T
T
V
P
V
T
V
N
T
T
D
-
H
---
N
T
F
Q
N
N
I
S
-
N
Y
L
Q
G
--
T
P
D
S
L
A
T
W
----
F
A
G
-
Y
R
L
Q
F
F
A
A
Q
G
L
L
T
P
I
D
D
V
W
D
K
I
G
G
T
-
F
N
D
A
A
K
S
L
S
K
---
G
L
D
G
H
Y
Y
L
V
P
L
Y
-
N
Y
-
P
W
V
V
F
Y
N
K
S
V
F
Q
S
K
G
Y
---
E
---
V
---
P
A
S
W
E
A
F
I
A
L
A
R
K
M
Q
S
D
--
G
--
L
-
V
P
-----
L
A
F
A
D
K
D
G
W
P
--
A
L
G
T
F
D
I
L
N
L
R
I
N
G
--
Y
D
Y
H
I
K
L
M
K
H
E
V
-
P
W
T
D
P
G
V
T
K
V
F
D
Q
W
R
E
L
--
A
------
A
Y
Q
Q
K
G
A
N
G
R
----
T
W
--
Q
D
-
A
A
K
A
L
E
N
K
Q
A
G
M
M
F
Q
G
S
--
N
Q
V
-
A
A
N
YSAK
N
-------
L
-------------
P
D
L
-----
D
F
F
V
-----------
F
P
A
I
N
P
Q
Y
-
G
-------
T
-
D
---
Y
M
D
A
P
T
D
G
F
I
-
L
P
K
K
--
G
K
N
A
A
A
A
K
K
V
L
Q
Y
I
G
T
A
E
A
E
A
A
F
L
K
T
-
D
H
W
D
V
G
-
L
A
N
G
L
I
A
--
P
-
T
----
Y
------
N
------
D
------
I
---
Q
K
K
S
-
V
-
A
E
I
G
-
K
----
C
K
S
V
S
Q
F
-
M
E
R
D
T
V
P
D
M
A
N
A
M
I
K
L
I
Q
Q
F
I
D
-
Q
P
T
P
E
T
I
A
T
V
Q
K
S
A
E
D
Q
A
K
T
I
F
R
-----------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
73.89
25%
32
- C1 -
4C1T
3
?
A:
[18-412]
----------------------------
D
D
K
-
T
I
T
F
W
H
N
A
S
A
G
E
G
R
Q
Y
W
E
N
L
A
K
S
F
E
E
----
A
N
P
G
T
K
V
E
I
Q
A
I
Q
-
N
---
E
D
F
A
G
K
L
Q
T
A
M
Q
D
P
-
A
S
G
P
D
V
F
M
S
----
L
G
G
-
A
K
T
K
E
M
I
D
A
G
Q
V
M
D
L
T
D
K
I
---
S
D
T
-
V
K
T
D
M
K
T
T
L
S
A
A
-
T
F
D
G
K
V
Y
G
V
P
V
S
-
V
E
-
P
G
G
M
W
Y
S
K
D
L
F
K
K
A
G
V
S--
D
---
V
---
P
A
T
Y
E
E
L
L
A
D
A
K
K
L
K
D
S
--
G
--
T
-
D
A
-----
I
A
L
G
A
K
D
A
W
P
--
A
A
H
W
Y
Y
W
L
V
L
R
E
C
S
--
P
E
V
Y
D
K
--
S
V
Q
D
H
D
F
S
N
A
C
W
V
N
A
G
K
K
L
Q
E
L
K
D
L
------
K
V
F
N
D
G
F
L
T
T
-----------
T
A
Q
Q
G
A
N
S
S
A
G
L
L
A
N
H
K
--
A
A
M
-
E
L
M
G
AW-
E
-------
P
G
V
L
K
D
L
TPDQKPM
A
D
L
-----
G
F
F
A
-----------
F
P
E
V
A
G
G
E
-
G
-------
E
-
P
-
G
-
A
L
M
G
G
V
T
Y
F
C
-
V
N
P
K
--
A
S
--
Q
T
S
I
D
F
V
N
Y
M
G
E
K
K
N
Q
E
D
Y
A
K
----
A
F
S
T
-
I
--
P
A
S
E
--
P
-
A
----
R
------
A
------
V
------
V
---
T
D
E
S
-
L
-
K
Q
V
I
-
E
Y
L
D
K
A
P
S
M
Q
L
W
-
M
D
T
A
L
G
T
N
I
G
N
A
L
N
A
A
V
V
N
M
L
S
G
Q
G
S
P
E
D
I
V
K
A
M
Q
D
A
A
Q
K
-----------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
73.42
25%
35
- C1 -
4C1U
5
?
A:
[18-412]
----------------------------
D
D
K
-
T
I
T
F
W
H
N
A
S
A
G
E
G
R
Q
Y
W
E
N
L
A
K
S
F
E
E
----
A
N
P
G
T
K
V
E
I
Q
A
I
Q
-
N
---
E
D
F
A
G
K
L
Q
T
A
M
Q
D
P
-
A
S
G
P
D
V
F
M
S
----
L
G
G
-
A
K
T
K
E
M
I
D
A
G
Q
V
M
D
L
T
D
K
I
---
S
D
T
-
V
K
T
D
M
K
T
T
L
S
A
A
-
T
F
D
G
K
V
Y
G
V
P
V
S
-
V
E
-
P
G
G
M
W
Y
S
K
D
L
F
K
K
A
G
V
S--
D
---
V
---
P
A
T
Y
E
E
L
L
A
D
A
K
K
L
K
D
S
--
G
--
T
-
D
A
-----
I
A
L
G
A
K
D
A
W
P
--
A
A
H
W
Y
Y
W
L
V
L
R
E
C
S
--
P
E
V
Y
D
K
--
S
V
Q
D
H
D
F
S
N
A
C
W
V
N
A
G
K
K
L
Q
E
L
K
D
L
------
K
V
F
N
D
G
F
L
T
T
-----------
T
A
Q
Q
G
A
N
S
S
A
G
L
L
A
N
H
K
--
A
A
M
-
E
L
M
G
AW-
E
-------
P
G
V
L
K
D
L
TPDQKPM
A
D
L
-----
G
F
F
A
-----------
F
P
E
V
A
G
G
E
-
G
-------
E
-
P
-
G
-
A
L
M
G
G
V
T
Y
F
C
-
V
N
P
K
--
A
S
--
Q
T
S
I
D
F
V
N
Y
M
G
E
K
K
N
Q
E
D
Y
A
K
----
A
F
S
T
-
I
--
P
A
S
E
--
P
-
A
----
R
------
A
------
V
------
V
---
T
D
E
S
-
L
-
K
Q
V
I
-
E
Y
L
D
K
A
P
S
M
Q
L
W
-
M
D
T
A
L
G
T
N
I
G
N
A
L
N
A
A
V
V
N
M
L
S
G
Q
G
S
P
E
D
I
V
K
A
M
Q
D
A
A
Q
K
-----------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
73.09
25%
34
- C1 -
3ZKK
2
?
A:
[18-412]
----------------------------
D
D
K
-
T
I
T
F
W
H
N
A
S
A
G
E
G
R
Q
Y
W
E
N
L
A
K
S
F
E
E
----
A
N
P
G
T
K
V
E
I
Q
A
I
Q
-
N
---
E
D
F
A
G
K
L
Q
T
A
M
Q
D
P
-
A
S
G
P
D
V
F
M
S
----
L
G
G
-
A
K
T
K
E
M
I
D
A
G
Q
V
M
D
L
T
D
K
I
---
S
D
T
-
V
K
T
D
M
K
T
T
L
S
A
A
-
T
F
D
G
K
V
Y
G
V
P
V
S
-
V
E
-
P
G
G
M
W
Y
S
K
D
L
F
K
K
A
G
V
S--
D
---
V
---
P
A
T
Y
E
E
L
L
A
D
A
K
K
L
K
D
S
--
G
--
T
-
D
A
-----
I
A
L
G
A
K
D
A
W
P
--
A
A
H
W
Y
Y
W
L
V
L
R
E
C
S
--
P
E
V
Y
D
K
--
S
V
Q
D
H
D
F
S
N
A
C
W
V
N
A
G
K
K
L
Q
E
L
K
D
L
------
K
V
F
N
D
G
F
L
T
T
-----------
T
A
Q
Q
G
A
N
S
S
A
G
L
L
A
N
H
K
--
A
A
M
-
E
L
M
G
AW-
E
-------
P
G
V
L
K
D
L
TPDQKPM
A
D
L
-----
G
F
F
A
-----------
F
P
E
V
A
G
G
E
-
G
-------
E
-
P
-
G
-
A
L
M
G
G
V
T
Y
F
C
-
V
N
P
K
--
A
S
--
Q
T
S
I
D
F
V
N
Y
M
G
E
K
K
N
Q
E
D
Y
A
K
----
A
F
S
T
-
I
--
P
A
S
E
--
P
-
A
----
R
------
A
------
V
------
V
---
T
D
E
S
-
L
-
K
Q
V
I
-
E
Y
L
D
K
A
P
S
M
Q
L
W
-
M
D
T
A
L
G
T
N
I
G
N
A
L
N
A
A
V
V
N
M
L
S
G
Q
G
S
P
E
D
I
V
K
A
M
Q
D
A
A
Q
K
-----------------------------------------------------------------------------------------------------------------
22
HHSearch
73.06
22%
30
- C1 -
3VXB
4
?
A:
[38-434]
--------------------------------
T
I
T
A
M
V
Y
G
D
--
D
A
V
K
V
Q
D
K
A
A
S
R
F
N
A
S
A
E
A
K
K
A
N
A
K
V
K
M
E
R
I
P
-
A
---
S
D
Y
P
A
K
L
R
-
T
A
M
G
S
-
P
N
A
P
D
I
F
F
N
----
W
G
G
-
G
S
I
K
A
Y
K
E
A
G
Q
L
V
D
L
T
D
V
I
K
S
D
E
V
L
-
S
T
G
F
L
P
S
V
V
A
A
G
-
S
L
D
G
H
E
Y
G
I
P
M
R
G
M
Q
-
P
V
L
L
F
Y
N
K
S
V
F
A
E
H
K
L
---
T
---
P
---
P
T
T
W
D
Q
L
L
D
N
V
A
K
L
K
K
A
--
G
--
V
-
T
P
-----
F
A
L
G
G
V
E
I
W
P
--
E
L
M
W
L
E
Y
L
V
D
R
I
G
G
--
P
Q
V
F
D
K
I
R
N
G
D
A
S
G
W
G
D
P
A
V
L
K
A
A
Q
T
V
K
Q
L
--
V
D
E
----
G
A
F
G
K
G
F
S
S
V
----
S
Y
NN
G
G
-
A
P
A
L
L
A
K
G
K
A
G
M
H
L
M
G
S
--
W
E
Y
S
T
Q
L
G
---
K
F
P
D
F
A
--
K
-------------
K
D
L
-----
G
W
C
A
-----------
F
P
S
F
E
G
G
A
-
G
-------
D
-
I
R
N
-
V
V
G
N
P
C
N
Y
W
S
-
V
N
A
R
--
T
G
N
K
D
G
A
I
A
F
L
R
D
C
A
S
E
A
Y
T
K
D
L
I
-
D
-
N
G
D
V
P
T
-
T
T
I
A
E
N
M
L-
D
S
S
----
P
------
N
------
P
------
E
---
F
A
K
F
-
Q
-
Y
Q
L
V
Q
K
----
A
P
N
F
T
L
S
-
W
D
Q
A
V
D
P
D
W
Q
Q
P
M
L
T
E
I
N
K
L
F
V
G
K
S
S
P
E
Q
F
V
S
A
L
K
G
---------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
72.15
23%
5
- C1 -
3VXB
4
?
A:
[64-433]
--------------------------------------------------------
E
A
----
K
K
A
N
A
K
V
K
M
E
R
I
P
-
A
---
S
D
Y
P
A
K
L
R
-
T
A
M
G
S
-
P
N
A
P
D
I
F
F
N
----
W
G
G
-
G
S
I
K
A
Y
K
E
A
G
Q
L
V
D
L
T
D
V
I
K
S
D
E
V
L
-
S
T
G
F
L
P
S
V
V
A
A
G
-
S
L
D
G
H
E
Y
G
I
P
M
R
G
M
Q
-
P
V
L
L
F
Y
N
K
S
V
F
A
E
H
K
L
---
T
---
P
---
P
T
T
W
D
Q
L
L
D
N
V
A
K
L
K
K
A
--
G
--
V
-
T
P
-----
F
A
L
G
G
V
E
I
W
P
--
E
L
M
W
L
E
Y
L
V
D
R
I
G
G
--
P
Q
V
F
D
K
I
R
N
G
D
A
S
G
W
G
D
P
A
V
L
K
A
A
Q
T
V
K
Q
L
--
V
D
E
----
G
A
F
G
K
G
F
S
S
V
----
S
Y
--
N
-------
N
G
G
A
P
A
L
L
A
K
G
K
--
A
G
M
-
H
L
M
----
G
SW
E
Y
---
S
-------------
T
Q
L
-----
G
K
F
P
D
F
A
K
KD
L
G
W
C
A
F
P
S
F
E
G
G
A
-
G
-------
D
-
I
-
R
-
N
V
V
G
N
P
C
N
Y
W
S
V
N
A
R
--
T
G
N
K
D
G
A
I
A
F
L
R
D
C
A
S
----
E
A
Y
T
K
D
-
L
I
D
N
G
D
-
V
P
T
T
T
I
A
--
E
-
N
----
M
------
L
DSSPN
P
E
------
F
---
A
K
F
Q
-
Y
-
Q
L
V
Q
-
K
----
A
P
N
F
T
L
S
-
W
D
Q
A
V
D
P
D
W
Q
Q
P
M
L
T
E
I
N
K
L
F
V
G
K
S
S
P
E
Q
F
V
S
A
L
K
----------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
71.86
25%
36
- C1 -
3ZKL
3
?
A:
[18-412]
----------------------------
D
D
K
-
T
I
T
F
W
H
N
A
S
A
G
E
G
R
Q
Y
W
E
N
L
A
K
S
F
E
E
----
A
N
P
G
T
K
V
E
I
Q
A
I
Q
-
N
---
E
D
F
A
G
K
L
Q
T
A
M
Q
D
P
-
A
S
G
P
D
V
F
M
S
----
L
G
G
-
A
K
T
K
E
M
I
D
A
G
Q
V
M
D
L
T
D
K
I
---
S
D
T
-
V
K
T
D
M
K
T
T
L
S
A
A
-
T
F
D
G
K
V
Y
G
V
P
V
S
-
V
E
-
P
G
G
M
W
Y
S
K
D
L
F
K
K
A
G
V
S--
D
---
V
---
P
A
T
Y
E
E
L
L
A
D
A
K
K
L
K
D
S
--
G
--
T
-
D
A
-----
I
A
L
G
A
K
D
A
W
P
--
A
A
H
W
Y
Y
W
L
V
L
R
E
C
S
--
P
E
V
Y
D
K
--
S
V
Q
D
H
D
F
S
N
A
C
W
V
N
A
G
K
K
L
Q
E
L
K
D
L
------
K
V
F
N
D
G
F
L
T
T
-----------
T
A
Q
Q
G
A
N
S
S
A
G
L
L
A
N
H
K
--
A
A
M
-
E
L
M
G
AW-
E
-------
P
G
V
L
K
D
L
TPDQKPM
A
D
L
-----
G
F
F
A
-----------
F
P
E
V
A
G
G
E
-
G
-------
E
-
P
-
G
-
A
L
M
G
G
V
T
Y
F
C
-
V
N
P
K
--
A
S
--
Q
T
S
I
D
F
V
N
Y
M
G
E
K
K
N
Q
E
D
Y
A
K
----
A
F
S
T
-
I
--
P
A
S
E
--
P
-
A
----
R
------
A
------
V
------
V
---
T
D
E
S
-
L
-
K
Q
V
I
-
E
Y
L
D
K
A
P
S
M
Q
L
W
-
M
D
T
A
L
G
T
N
I
G
N
A
L
N
A
A
V
V
N
M
L
S
G
Q
G
S
P
E
D
I
V
K
A
M
Q
D
A
A
Q
K
-----------------------------------------------------------------------------------------------------------------
39
HHSearch
69.73
23%
27
- C1 -
4RJZ
2
?
A:
[26-405]
-------------------------------
V
T
L
T
L
W
S
L
D
R
---
D
I
Q
P
A
P
N
L
I
K
E
F
N
A
----
L
N
N
G
I
K
I
E
Y
R
Q
L
Q
-
F
---
D
D
V
V
S
E
S
M
-
R
A
Y
S
T
-
G
N
A
P
D
I
I
A
I
----
D
N
--
P
N
H
A
M
F
A
S
R
G
A
F
L
D
V
T
D
M
I
A
K
S
D
V
I
K
T
E
N
Y
F
P
G
P
L
K
S
V
-
T
W
D
G
K
Y
F
G
V
P
K
A
-
T
N
-
T
I
A
L
Y
Y
N
K
D
L
F
K
A
A
G
L
---
D
AAK
P
---
P
Q
T
W
D
E
L
V
D
A
A
R
K
L
T
N
P
AK
N
--
V
-
Y
G
-----
I
S
F
S
A
K
A
N
E
E
--
G
-
T
F
Q
F
L
P
W
A
Q
M
A
G
--
A
T
Y
---------
K
N
I
N
T
D
G
A
V
K
A
L
E
T
W
K
T
L
--
L
D
E
----
K
L
A
S
P
D
T
L
T
R
----
S
Q
--
W
D
-
S
T
A
T
F
N
A
G
N
A
A
M
A
I
S
G
P
--
W
E
I
D
R
M
L
----
K
DA-----
K
-------------
F
D
W
-----
G
V
T
L
-----------
L
P
V
P
T
P
D
A
-
P
-------
R
-
S
-
S
-
A
M
G
--
D
Y
N
W
A
-
I
F
S
K
--
T
K
H
P
A
E
A
F
K
A
I
E
F
F
A
S
K
D
K
D
M
-
F
-
K
N
-
F
G
Q
L
P
A
-
R
S
D
I
P
V
P
--
P
-
T
GN
A
L
K
------
D
------
E
------
A
---
L
K
T
F
-
V
-
E
Q
L
K
-
Y
----
A
Q
P
R
G
-
P
---
S
P
E
W
P
K
I
S
K
A
I
Q
D
A
I
Q
G
A
L
S
G
Q
M
T
P
K
A
A
L
D
Q
A
A
E
K
I
K
L
V
----------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
68.80
23%
7
- C1 -
3VXC
1
?
A:
[64-433]
--------------------------------------------------------
E
A
----
K
K
A
N
A
K
V
K
M
E
R
I
P
-
A
---
S
D
Y
P
A
K
L
R
-
T
A
M
G
S
-
P
N
A
P
D
I
F
F
N
----
W
G
G
-
G
S
I
K
A
Y
K
E
A
G
Q
L
V
D
L
T
D
V
I
K
S
D
E
V
L
-
S
T
G
F
L
P
S
V
V
A
A
G
-
S
L
D
G
H
E
Y
G
I
P
M
R
G
M
Q
-
P
V
L
L
F
Y
N
K
S
V
F
A
E
H
K
L
---
T
---
P
---
P
T
T
W
D
Q
L
L
D
N
V
A
K
L
K
K
A
--
G
--
V
-
T
P
-----
F
A
L
G
G
V
E
I
W
P
--
E
L
M
W
L
E
Y
L
V
D
R
I
G
G
--
P
Q
V
F
D
K
I
R
N
G
D
A
S
G
W
G
D
P
A
V
L
K
A
A
Q
T
V
K
Q
L
--
V
D
E
----
G
A
F
G
K
G
F
S
S
V
----
S
Y
--
N
-------
N
G
G
A
P
A
L
L
A
K
G
K
--
A
G
M
-
H
L
M
----
G
SW
E
Y
---
S
-------------
T
Q
L
-----
G
K
F
P
D
F
A
K
KD
L
G
W
C
A
F
P
S
F
E
G
G
A
-
G
-------
D
-
I
-
R
-
N
V
V
G
N
P
C
N
Y
W
S
V
N
A
R
--
T
G
N
K
D
G
A
I
A
F
L
R
D
C
A
S
----
E
A
Y
T
K
D
-
L
I
D
N
G
D
-
V
P
T
T
T
I
A
--
E
-
N
----
M
------
L
DSSPN
P
E
------
F
---
A
K
F
Q
-
Y
-
Q
L
V
Q
-
K
----
A
P
N
F
T
L
S
-
W
D
Q
A
V
D
P
D
W
Q
Q
P
M
L
T
E
I
N
K
L
F
V
G
K
S
S
P
E
Q
F
V
S
A
L
K
----------------------------------------------------------------------------------------------------------------------
34
HHSearch
68.49
19%
14
- C1 -
3OO8
8
?
A:
[26-413]
-----------------------------
G
N
G
P
I
T
F
G
S
N
Y
S
D
E
A
P
K
A
A
F
A
S
L
M
Q
Q
A
T
T
-----
S
T
T
V
P
V
T
V
N
T
T
D
-
H
---
N
T
F
Q
N
N
I
S
-
N
Y
L
Q
--
G
T
P
D
S
L
A
T
W
----
F
A
G
-
Y
R
L
Q
F
F
A
A
Q
G
L
L
T
P
I
D
D
V
W
D
K
I
----
G
G
T
F
N
D
A
A
K
S
L
S
K
G
L
D
G
H
Y
Y
L
V
P
L
Y
-
N
Y
-
P
W
V
V
F
Y
N
K
S
V
F
Q
S
K
G
Y
---
E
---
V
---
P
A
S
W
E
A
F
I
A
L
A
R
K
M
Q
S
D
--
G
--
L
-
V
P
-----
L
A
F
A
D
K
D
G
W
P
--
A
L
G
T
F
D
I
L
N
L
R
I
N
G
--
Y
D
Y
H
I
K
L
M
K
H
E
-
V
P
W
T
D
P
G
V
T
K
V
F
D
Q
W
R
E
L
--
A
------
A
Y
Q
Q
K
G
A
N
G
R
----
T
W
--
Q
D
-
A
A
K
A
L
E
N
K
Q
A
G
M
M
F
Q
G
S
--
N
Q
V
A
A
N
Y
----
S
AKN----
L
-------------
P
D
L
-----
D
F
F
V
-----------
F
P
A
I
N
P
Q
Y
-
G
-------
T
-
D
Y
M
-
D
A
P
--
T
D
G
F
I
-
L
P
K
K
--
G
K
N
A
A
A
A
K
K
V
L
Q
Y
I
G
T
A
E
A
E
A
A
F
L
K
T
-
D
H
W
D
V
G
L
A
N
G
L
I
A
---
P
-
T
----
Y
------
N
------
D
------
I
---
Q
K
K
S
-
V
-
A
E
I
G
-
K
----
C
K
S
V
S
Q
F
-
M
E
R
D
T
V
P
D
M
A
N
A
M
I
K
L
I
Q
Q
F
I
D
Q
-
P
T
P
E
T
I
-
A
T
V
Q
K
S
A
E
D
Q
A
K
T
I
------------------------------------------------------------------------------------------------------------
50
Fugue
68.22
20%
-11
- C1 -
1Y4C
1
MALE_ECOLI
A:
[4-493]
------------------------------
E
G
K
L
V
I
W
I
N
--
G
D
K
G
Y
N
G
L
A
E
V
G
K
K
F
E
K
----
D
T
---
G
I
K
V
T
V
E
H
-
P
---
D
K
L
E
E
K
F
P
-
Q
V
A
A
T
-
G
D
G
P
D
I
I
F
W
----
A
H
D
-
R
F
G
-
G
Y
A
Q
S
G
L
L
A
E
I
T
P
D
K
A
F
Q
D
K
L
-
Y
P
F
T
W
D
A
----
V
-
R
Y
N
G
K
L
I
A
Y
P
I
A
-
V
E
-
A
L
S
L
I
Y
N
K
D
L
L
P
N
----------
P
---
P
K
T
W
E
E
I
P
A
L
D
K
E
L
K
A
K
--
G
--
K
-
S
A
-----
L
M
F
N
L
Q
E
P
Y
F
--
T
W
P
L
I
A
A
D
G
G
Y
A
F
K
--
Y
E
--
N
G
K
Y
D
I
K
D
V
G
V
D
N
A
G
A
K
A
G
L
T
F
L
V
D
L
--
I
------
K
N
-
K
H
M
N
A
D
T
----
D
Y
--
S
I
-
A
E
A
A
F
N
K
G
E
T
A
M
T
I
N
G
P
--
W
A
W
-
S
N
I
----
D
T
S
-----
K
-------------
V
N
Y
-----
G
V
T
V
-----------
L
P
T
F
K
G
Q
P
-
S
-------
K
-
P
-----
F
V
G
V
L
S
A
G
-
I
N
A
A
--
S
P
N
K
E
L
A
K
E
F
L
E
N
Y
L
L
T
D
E
G
L
E
A
V
N
K
-
D
K
P
L
G
A
-
V
A
L
K
S
Y
E
--
E
-
E
----
L
------
A
------
K
----------
D
P
R
I
-
A
-
A
T
M
E
-
N
----
A
Q
K
G
E
I
M
-
P
N
I
P
Q
M
S
A
F
W
Y
A
V
R
T
A
V
I
N
A
A
S
G
R
Q
T
V
D
E
A
L
K
D
A
Q
T
N
S
S
S
L
G
I
E
G
R
S
S
E
E
L
L
K
I
A
L
Q
E
A
Q
K
T
L
Q
Q
A
Q
E
L
A
K
KGGG
E
E
Q
L
K
R
A
L
K
R
A
D
R
N
L
W
A
A
Q
E
L
A
K
K
GGGGE
E
L
L
K
Q
A
L
Q
Q
A
Q
Q
L
L
R
Q
A
Q
E
L
A
K
K
GGG
E
E
L
L
K
Q
A
L
Q
Q
A
Q
Q
L
L
Q
Q
A
Q
E
L
AK
32
HHSearch
66.92
19%
25
- C1 -
2B3F
1
?
A:
[1-391]
-------------------------------
M
K
L
E
I
F
S
W
W
A
G
-
D
E
G
P
A
L
E
A
L
I
R
L
Y
K
Q
----
K
Y
P
G
V
E
V
I
N
A
T
V
T
-
G
G
AG
V
N
A
R
A
V
L
K
-
T
R
M
L
G
-
G
D
P
P
D
T
F
Q
V
----
H
A
G
M
E
L
I
G
T
W
V
V
A
N
R
M
E
D
L
S
A
L
F
R
Q
E
G
-
W
-
L
Q
A
F
P
K
G
L
I
D
L
I
-
S
Y
K
G
G
I
W
S
V
P
V
N
-
I
H
R
S
N
V
M
W
Y
L
P
A
K
L
K
G
W
G
V
---
N
---
P
---
P
R
T
W
D
K
F
L
A
T
C
Q
T
L
K
Q
K
--
G
--
L
E
A
P
-----
L
A
L
G
E
--
N
W
T
--
Q
Q
H
L
W
E
S
V
A
L
A
V
L
G
--
P
D
D
W
N
N
L
W
N
G
K
-
L
K
F
T
D
P
K
A
V
R
A
W
E
V
F
G
R
V
--
L
------
D
C
A
N
K
D
A
A
G
L
----
S
W
--
Q
Q
-
A
V
D
R
V
V
Q
G
K
A
A
F
N
I
M
G
D
--
W
A
A
G
Y
M
T
----
T
TLKLKP-
G
-------------
T
D
F
-----
A
W
A
P
-----------
S
P
G
T
Q
G
-
V
-------------
F
-
M
M
L
--
S
D
S
F
G
-
L
P
K
G
--
A
K
N
R
Q
N
A
I
N
W
L
R
L
V
G
S
K
E
G
Q
D
T
S
N
P
L
-
K
G
S
I
A
A
-
R
L
D
S
D
P
S
--
K
------
Y
------
N
------
A
------
Y
---
G
Q
S
A
-
M
-
R
D
W
R
-
S
----
N
R
I
V
G
S
L
V
H
G
A
V
A
P
E
S
F
M
S
Q
F
G
T
V
M
E
I
F
L
-
Q
T
R
N
P
Q
A
A
A
N
A
A
Q
A
I
A
D
Q
V
G
L
G
R
------------------------------------------------------------------------------------------------------------
30
HHSearch
65.75
20%
-14
- C1 -
5CI5
1
?
A:
[22-414]
------------------------------
S
K
T
L
T
I
W
I
G
G
Q
V
A
E
L
D
E
T
W
N
S
V
I
K
T
F
E
E
----
K
Y
-
G
I
S
V
E
V
Q
L
F
G
-
F
---
D
T
Y
Y
D
K
L
V
-
T
A
L
Q
A
-
G
K
G
P
D
L
A
F
A
----
D
L
G
-
G
W
V
P
T
F
A
E
K
G
W
L
E
P
M
E
E
H
L
K
N
W
E
G
T
--
A
Q
I
W
P
N
L
W
P
T
V
-
T
Y
K
K
I
R
Y
G
L
P
W
Y
-
T
D
-
C
R
L
L
L
Y
N
K
A
M
F
E
K
A
G
L
---
N
PDN
P
---
P
K
T
W
D
E
L
L
D
A
A
L
K
I
T
D
T
--
K
NR
I
-
Y
G
-----
Y
G
V
S
G
T
K
T
E
H
--
T
T
L
G
Y
M
M
F
-
L
Y
A
A
G
--
G
K
L
L
T
D
D
-
Y
S
K
-
A
A
F
D
S
P
E
G
L
K
A
L
K
F
Y
T
D
L
--
A
KK----
Y
N
V
S
P
N
A
I
Q
Y
----
H
E
--
D
D
-
Y
R
N
M
M
A
Q
N
R
V
A
M
A
I
G
G
P
--
W
S
F
P
L
I
E
----
A
A
NPDI--
A
-------------
G
K
Y
-----
S
V
A
L
-----------
H
P
Y
D
A
K
P
A
-------------
S
-
V
L
G
--
G
W
A
L
V
-
I
P
S
S
--
S
P
N
K
E
D
A
W
K
L
A
E
Y
L
T
S
F
D
V
W
M
K
W
V
E
E
K
G
G
P
M
P
T
-
R
M
D
V
C
K
K
S-
K
L
A
----
N
------
D
------
V
------
K
---
W
Q
I
I
-
F
-
E
T
F
P
-
H
----
A
V
A
R
P
-
P
---
I
P
Q
Y
P
Q
I
S
E
Q
I
Q
T
M
V
Q
R
V
L
L
G
E
L
T
P
E
E
A
I
K
I
A
A
E
N
V
N
K
I
L
G
A
-------------------------------------------------------------------------------------------------------------
45
Fugue
64.52
18%
1
- C1 -
2UVH
2
?
A:
[5-408]
----------------------------
E
V
N
L
R
M
S
W
W
G
---
G
N
G
R
H
Q
V
T
L
K
A
L
E
E
F
H
K
----
Q
H
P
N
I
N
V
K
A
E
Y
T
G
-
W
---
D
G
H
L
S
R
L
T
-
T
Q
I
A
G
-
G
T
E
P
D
V
M
Q
T
-----
N
W
-
N
W
L
P
I
F
S
K
D
G
T
G
F
Y
N
L
F
S
V
K
E
Q
L
D
--
L
A
Q
F
D
P
K
E
L
Q
Q
T
-
T
V
N
G
K
L
N
G
I
P
I
S
-
V
T
-
A
R
I
F
Y
F
N
D
A
T
W
A
K
A
G
L
---
E
---
Y
---
P
K
T
W
D
E
L
L
A
A
G
K
V
F
K
E
K
--
L
--
G
-
D
Q
YYP
V
V
L
E
H
Q
D
T
L
A
L
I
--
R
S
Y
M
T
Q
K
Y
N
I
P
T
I
D
--
E
A
N
-------
K
K
F
A
Y
S
P
E
Q
W
V
E
F
F
T
M
Y
K
T
M
--
V
D
N
HVMP
S
T
K
Y
Y
A
S
F
G
K
----
S
N
--
M
Y
-
E
M
K
P
W
I
N
G
E
W
A
G
T
Y
M
W
N
--
S
T
I
-
T
K
Y
----
S
DNLTK--
P
-------------
A
K
L
-----
V
L
G
P
-----------
Y
P
M
L
P
G
A
K
-
D
-------
A
-
G
---
L
F
F
K
P
A
Q
M
L
S
-
I
G
K
S
--
T
K
H
P
Q
E
S
A
M
L
I
N
F
L
L
N
S
K
E
G
V
E
A
L
G
L
-
E
R
G
V
P
L
-
S
A
T
A
V
T
Q
--
L
-
R
----
A
S
GVIKD
E
------
D
------
P
---
S
V
A
G
-
L
-
N
M
A
L
-
E
----
L
P
H
K
M
T
T
-
S
P
Y
F
D
D
P
Q
I
V
S
L
F
G
D
A
I
Q
Y
I
D
Y
G
Q
K
T
V
Q
E
T
A
E
Y
F
N
K
Q
G
D
R
I
L
K
R
A
M
R----------------------------------------------------------------------------------------------------------
31
HHSearch
62.57
20%
27
- C1 -
4R6K
1
YESO_BACSU
A:
[32-427]
-----------------------------
E
D
V
T
L
R
I
A
W
-
W
G
G
Q
P
R
H
D
Y
T
T
K
V
I
E
L
Y
E
K
----
K
N
P
H
V
H
I
E
A
E
F
A
N
-
W
---
D
D
Y
W
K
K
L
A
-
P
M
S
A
A
-
G
Q
L
P
D
V
I
Q
M
----
D
T
--
A
Y
L
A
Q
Y
G
K
K
N
Q
L
E
D
L
T
P
Y
T
K
D
G
T
I
D
-
V
S
S
I
D
E
N
M
L
S
G
G
-
K
I
D
N
K
L
Y
G
F
T
L
G
-
V
N
-
V
L
S
V
I
A
N
E
D
L
L
K
K
A
G
V
---
S
---
I
NQE
N
W
T
W
E
D
Y
E
K
L
A
Y
D
L
Q
E
K
A-
G
--
V
-
Y
G
-----
S
N
G
M
H
P
------
P
D
I
F
F
P
-
Y
Y
L
R
T
K
G
--
E
R
F
Y
K
E
D
G
T
G
L
-
A
Y
Q
D
D
Q
L
F
V
D
Y
F
E
R
Q
L
R
L
--
V
K
A
----
K
T
S
P
T
P
D
E
S
A
----
Q
I
--
K
G
M
E
D
D
F
I
V
K
G
K
S
A
I
T
W
N
Y
S
--
N
Q
Y
L
G
F
A
----
R
L
T
-----
D
-------------
S
P
L
-----
S
L
Y
L
-----------
P
P
E
Q
M
Q
E
K
-
A
---------
L
-
T
-
L
K
P
--
S
M
L
F
S
-
I
P
K
S
--
S
E
H
K
K
E
A
A
K
F
I
N
F
F
V
N
N
E
E
A
N
Q
L
I
K
G
-
E
R
G
V
P
V
-
S
D
K
V
A
D
A
I
K
P
-
K
----
L
------
N
------
E
------
E
E
T
N
I
V
E
Y
-
V
-
E
T
A
S
-
K
----
N
I
S
K
A
D
P
-
P
E
P
V
G
S
A
E
V
I
K
L
L
K
D
T
S
D
Q
I
L
Y
Q
K
V
S
P
E
K
A
A
K
T
F
R
K
K
A
N
E
I
L
E
R
N
------------------------------------------------------------------------------------------------------------
35
HHSearch
62.51
22%
34
- C1 -
3QUF
3
?
A:
[27-411]
----------------------------
G
G
K
T
K
I
S
F
Y
S
Y
F
K
D
----
N
Q
I
G
E
V
V
K
G
F
E
K
----
K
N
P
D
I
T
L
D
V
Q
Y
G
Q
D
P
---
A
Q
Y
I
S
T
L
Q
-
T
R
L
A
G
-
G
K
P
P
T
I
F
N
L
----
T
M
--
D
N
R
T
D
V
M
K
S
G
A
A
L
D
I
S
G
E
D
-----
F
-
L
D
G
I
D
D
T
N
F
A
L
F
-
Q
Q
D
G
K
T
Y
G
M
P
V
S
-
A
W
-
V
G
A
F
F
Y
N
K
D
I
L
K
K
A
G
Y
---
D
K--
F
---
P
K
T
W
D
E
F
I
E
M
G
K
K
I
N
S
N
--
G
--
S
-
T
A
-----
F
L
E
D
F
N
T
Q
I
A
G
S
F
T
G
L
L
A
S
Y
Y
-
G
E
Q
G
KS
G
D
L
D
A
D
I
W
S
G
K
-
S
T
F
T
K
-
D
W
T
P
V
F
K
R
W
E
A
A
--
A
K
A
----
G
V
I
P
Q
K
S
V
G
L
----
S
A
--
D
Q
-
V
K
Q
E
F
V
S
G
N
L
G
V
M
R
S
G
P
--
W
D
L
P
D
L
Q
----
K
S------
D
-------------
I
D
F
-----
G
V
A
P
-----------
F
P
A
Y
S
K
E
D
-
G
-------
Q
-
W
---
I
N
G
G
P
D
Q
G
F
A
-
I
A
S
R
AS
D
K
E
K
A
A
A
K
K
F
L
A
Y
L
N
S
E
E
G
L
E
A
F
T
S
A
-
A
G
T
L
S
L
-
S
S
K
Y
N
A
E
--
P
-------------
P
------
A
------
E
---
L
K
D
V
-
V
D
N
Y
F
K
-
Q
----
N
K
F
Y
W
V
N
-
W
P
-
K
S
P
T
V
M
S
T
E
G
I
A
Q
Q
Q
K
I
V
Q
G
Q
I
S
A
K
D
A
A
K
A
L
D
A
K
W
A
T
L
----------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
61.15
22%
22
- C1 -
5CI5
1
?
A:
[40-414]
------------------------------------------------
W
N
S
V
I
K
T
F
E
E
----
K
Y
-
G
I
S
V
E
V
Q
L
F
G
-
F
---
D
T
Y
Y
D
K
L
V
-
T
A
L
Q
A
-
G
K
G
P
D
L
A
F
A
D
LGG
W
V
P
-
T
F
A
E
K
-----
G
W
L
E
P
M
E
E
H
L
K
N
W
E
G
-
T
A
Q
I
W
P
N
L
W
P
T
V
-
T
Y
K
K
I
R
Y
G
L
P
W
Y
-
T
D
-
C
R
L
L
L
Y
N
K
A
M
F
E
K
A
G
L
NPD
N
---
P
---
P
K
T
W
D
E
L
L
D
A
A
L
K
I
T
D
T
--
K
--
N
-
R
I
-----
Y
G
Y
G
V
S
G
T
K
T
--
E
H
T
T
L
G
Y
M
M
F
L
Y
A
A
--
G
G
K
L
L
T
D
D
Y
S
K
A
A
F
D
S
P
E
G
-
L
K
A
L
K
F
Y
T
D
L
--
A
------
K
K
Y
N
V
S
P
N
A
I
----
Q
Y
H
E
D
D
-
Y
R
N
M
M
A
Q
N
R
V
A
M
A
I
G
G
P
--
W
S
F
-
P
L
I
----
E
-------
A
-------------
A
N
----------------------
P
D
I
A
G
K
Y
-
S
V
A
LHPYD
A
-
K
-
P
-
A
S
V
L
G
G
W
A
L
V
-
I
P
S
S
--
S
P
N
K
E
D
A
W
K
L
A
E
Y
L
T
S
F
D
V
W
M
K
W
V
E
E
-
K
G
G
P
M
P
-
T
R
M
D
V
C
K
--
K
-
S
----
K
------
L
------
A
ND
V
K
W
Q
I
---
I
F
E
T
-
F
-
P
H
A
V
------
A
R
P
P
I
P
Q
-
Y
P
-----
Q
I
S
E
Q
I
Q
T
M
V
Q
R
V
L
L
G
E
L
T
P
E
E
A
I
K
I
A
A
E
N
V
N
K
I
L
G
A
-------------------------------------------------------------------------------------------------------------