@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu32820: (2016-07-24 )
MAKKAADVQKGGGFLIEDVTYDQMYTPEDFTDEHKMIAKTTEDYIEQDVLPHIDDIENHQFEHSVRLLKKAGELGLLGADVPEEYGGLGLDKISSALITEKFSRAGSFSLSYGAHVGIGSLPIVFFGSEEQKKKYLPGLASGEKIAAYALTEPGSGSDALGAKTTAVLNEAGTHYVLTGEKQWITNSAFADVFVVYAKVDGDKFSAFIVEKEFPGVSTGPEEKKMGIKGSSTRTLILDQAEVPKENLLGEIGKGHVIAFNILNIGRYKLAVGTIGASKRVIELSAAYANQRRQFKTPIAGFSLTQEKIGTMASRLYAMESSVYRTVGLFEDNMSQFTAEDLKDGRQIAKSIAEYAIECSLNKVFGSETLDYIVDEGVQIHGGYGFMQEYEVERAYRDSRINRIFEGTNEINRLIVPSTFLKKALKGELPLFEKAQSLQEELMMLMPEEPGSGVLEQEKYIVKQAKKIALFAAGLAAQKYGKAIDREQEILVNVADIVSNVYAMESAVLRTEKAIAAQGAEKAAQKVLYTEIFVQEAFNEIEAHAKESLIAMEEGDSLRMMLSALRKLTRVTPKNVIQKKREAAAGIFEAEKYTV
Atome Classification :
(36 SA)
.........10........20.-....-----...30...----..----...40........50.......-.60......----..70........80........90.---.......100..-.--.-.-----..-110-........120.......130.......140.......150.......160.......170.......180.......190.......200-------.---------.----.-------......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310----........320.......330.......340.......350.......360.......370.......380.......390.......400.......410....----------...420.....--..430.....--..440---.......---..-450.-----.......----460.......470........480.......490.......500.......510....-...520.......530.......540.......550.......560.......570.-......580.......590..--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAKKAADVQKG
G
G
F
L
I
E
DVTYD-QMYT-----PEDF
T
D
E
H
----
K
M
----
I
A
K
T
T
E
D
Y
I
E
Q
DVLPHIDDIEN-
H
Q
F
E
H
S
V
R
L
----
L
K
KAGELGLLGADV
P
E
E
YGGL
G
L
D
K
---
I
S
S
A
L
I
T
E
K
F
SR-A--G-S-----
F
S
-LS--YGAHVGIGS
L
P
I
V
F
FGS
E
E
Q
K
K
K
YLPGLASG
E
K
I
A
A
Y
A
LTEPGSGSDALGA
K
T
T
A
V
LNEAG
T
H
Y
V
L
TGEKQWITNSAF
A
D
V
F
V
V
Y
A
KVD---------G---------D----K-------
F
S
A
F
I
V
EKEFPGVSTG
P
E
E
K
KMGIKGSS
T
R
T
L
I
L
DQAEV
P
K
E
N
L
L
G
EIGKG
H
V
I
A
F
N
I
LNIG
R
Y
K
L
A
V
G
TIGAS
K
R
V
I
E
L
S
A
A
Y
A
NQ
R
R
Q
FKTPIAGF
S
L
T
Q
E
K
I
G
T
M
-----
A
S
R
L
Y
A
M
E
S
S
V
Y
R
T
V
GLFED
N
M
S
Q
F
T
A
E
D
L
K
D
G
R
Q
I
A
K
S
I
A
E
Y
A
I
E
C
S
L
N
K
VFG
S
E
T
L
D
Y
I
V
DE
G
V
Q
I
HGGYG
F
M
Q
E
Y
E
V
E
R
A
Y
R
D
S
R
I
N
R
I
F
E
G
T
N
E
I
N
R
L
IV
P
----------
S
T
F
L
K
K
A
LKGE--L
P
L
F
E
K
A
Q
S
L
--
Q
E
E
-----
L
M
M
LMPE---EP-G-SG-----
V
L
E
Q
E
K
Y
----
I
V
K
Q
A
K
K
I
A
L
F
A
-
A
G
L
A
A
Q
K
Y
G
K
A
ID
R
E
Q
E
I
L
V
N
V
A
D
I
V
S
N
V
Y
A
M
E
S
A
V
L
R
T
E
K
A
I
A
A-Q
G
A
E
K
A
A
Q
K
V
L
Y
T
E
I
F
V
Q
E
A
F
N
E
I
E
A
H
A
K
E
S
L
I
AMEEG
D
S
L
R
M
M
L
S
A
L
R
K
L
TRV
T
P
K
-
N
V
I
Q
K
K
R
E
A
AAGIFEAEKYTV--
1
PsiBlast_PDB
96.68
74%
-66
- C2 -
3OWA
7
?
A:
[11-597]
-------
A
V
K
G
G
S
F
L
V
D
E
I
T
I
D
-
Q
V
F
T
-----
P
E
D
F
S
S
E
H
----
K
M
----
I
A
K
T
T
E
D
F
I
V
N
E
V
L
P
E
L
E
Y
L
E
Q
-
H
E
F
D
R
S
V
R
L
----
L
K
E
A
G
E
L
G
L
L
G
A
D
V
P
E
E
Y
G
G
I
G
L
D
K
---
V
S
S
A
L
I
A
E
K
F
S
R
-
A
--
G
-
G
-----
F
A
-
I
T
--
H
G
A
H
V
G
I
G
S
L
P
I
V
L
F
G
N
E
E
Q
K
K
K
Y
L
P
L
L
A
T
G
E
K
L
A
A
Y
A
L
T
E
P
G
S
G
S
D
A
L
G
A
K
T
T
A
R
L
N
A
E
G
T
H
Y
V
L
N
G
E
K
Q
W
I
T
N
S
A
F
A
D
V
F
I
V
Y
A
K
I
D
---------
G
---------
E
----
H
-------
F
S
A
F
I
V
E
K
D
Y
A
G
V
S
T
S
P
E
E
K
K
M
G
I
K
C
S
S
T
R
T
L
I
L
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D
A
L
V
P
K
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N
L
L
G
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I
G
K
G
H
I
I
A
F
N
I
L
N
I
G
R
Y
K
L
G
V
G
T
V
G
S
A
K
R
A
V
E
I
S
A
Q
Y
A
N
Q
R
Q
Q
F
K
Q
P
I
A
R
F
P
L
I
Q
E
K
L
A
N
M
-----
A
A
K
T
Y
A
A
E
S
S
V
Y
R
T
V
G
L
F
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R
M
S
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K
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K
A
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A
A
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A
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S
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N
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V
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T
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D
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G
V
Q
I
H
G
G
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G
F
M
A
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M
Y
R
D
S
R
I
N
R
I
F
E
G
T
N
E
I
N
R
L
I
V
P
----------
G
T
F
L
R
K
A
M
K
G
E
--
L
P
L
L
Q
K
A
Q
K
L
--
Q
E
E
-----
L
M
M
M
------
E
V
-
G
-
D
E
-----
P
L
A
L
Q
K
Y
----
L
V
N
N
A
K
K
I
G
L
M
V
-
A
G
L
A
A
Q
K
Y
G
K
A
L
D
K
E
Q
E
I
L
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N
I
A
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I
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N
L
Y
A
M
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S
A
V
L
R
T
E
K
A
I
K
T
-
T
G
L
E
K
N
K
Q
K
V
L
Y
T
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V
F
C
Q
E
A
F
N
E
I
E
A
H
A
K
E
T
L
I
A
V
E
N
G
D
M
L
R
M
M
L
S
S
L
R
K
L
T
R
H
T
P
L
-
N
V
I
P
K
K
R
E
I
A
A
K
I
L
E
D
E
R
Y
T
V
--
111
HHSearch
89.99
75%
-37
- C2 -
3OWA
7
?
A:
[11-597]
-------
A
V
K
G
G
S
F
L
V
D
E
I
T
I
D
-
Q
V
F
T
-----
P
E
D
F
S
S
E
H
----
K
M
----
I
A
K
T
T
E
D
F
I
V
N
E
V
L
P
E
L
E
Y
L
E
Q
-
H
E
F
D
R
S
V
R
L
----
L
K
E
A
G
E
L
G
L
L
G
A
D
V
P
E
E
Y
G
G
I
G
L
D
K
---
V
S
S
A
L
I
A
E
K
F
S
R
-
A
--
G
-
G
-----
F
A
-
I
T
--
H
G
A
H
V
G
I
G
S
L
P
I
V
L
F
G
N
E
E
Q
K
K
K
Y
L
P
L
L
A
T
G
E
K
L
A
A
Y
A
L
T
E
P
G
S
G
S
D
A
L
G
A
K
T
T
A
R
L
N
A
E
G
T
H
Y
V
L
N
G
E
K
Q
W
I
T
N
S
A
F
A
D
V
F
I
V
Y
A
K
I
D
---------
G
---------
E
----
H
-------
F
S
A
F
I
V
E
K
D
Y
A
G
V
S
T
S
P
E
E
K
K
M
G
I
K
C
S
S
T
R
T
L
I
L
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D
A
L
V
P
K
E
N
L
L
G
E
I
G
K
G
H
I
I
A
F
N
I
L
N
I
G
R
Y
K
L
G
V
G
T
V
G
S
A
K
R
A
V
E
I
S
A
Q
Y
A
N
Q
R
Q
Q
F
K
Q
P
I
A
R
F
P
L
I
Q
E
K
L
A
N
M
-----
A
A
K
T
Y
A
A
E
S
S
V
Y
R
T
V
G
L
F
E
S
R
M
S
T
L
S
E
E
E
V
K
D
G
K
A
V
A
A
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I
A
E
Y
A
I
E
C
S
L
N
K
V
F
G
S
E
V
L
D
Y
T
V
D
E
G
V
Q
I
H
G
G
Y
G
F
M
A
E
Y
E
I
E
R
M
Y
R
D
S
R
I
N
R
I
F
E
G
T
N
E
I
N
R
L
I
V
P
----------
G
T
F
L
R
K
A
M
K
G
E
--
L
P
L
L
Q
K
A
Q
K
L
--
Q
E
E
-----
L
M
M
M
--
E
---
V
G
-
D
-
E
P
------
L
-
A
L
Q
K
----
Y
L
V
N
N
A
K
K
I
G
L
M
V
A
G
L
A
A
Q
K
Y
G
K
A
L
D
K
E
Q
E
I
L
V
N
I
A
D
I
V
S
N
L
Y
A
M
E
S
A
V
L
R
T
E
K
A
I
K
T
T
G
L
E
-
K
N
K
Q
K
V
L
Y
T
E
V
F
C
Q
E
A
F
N
E
I
E
A
H
A
K
E
T
L
I
A
V
E
N
G
D
M
L
R
M
M
L
S
S
L
R
K
L
T
R
H
T
P
L
-
N
V
I
P
K
K
R
E
I
A
A
K
I
L
E
D
E
R
Y
T
V
--
2
PsiBlast_PDB
87.08
54%
-73
- C2 -
2Z1Q
2
?
A:
[9-575]
--------
Q
K
G
G
G
W
L
L
E
--
V
P
E
-
R
V
Y
T
-----
P
E
D
F
D
E
S
V
----
K
E
----
I
A
R
T
T
R
T
F
V
E
R
E
V
L
P
L
L
E
R
M
E
H
-
G
E
L
E
L
N
V
P
L
----
M
R
K
A
G
E
L
G
L
L
A
I
D
V
P
E
E
Y
G
G
L
D
L
P
K
---
V
I
S
T
V
V
A
E
E
L
S
G
-
S
--
G
-
G
-----
F
S
-
V
T
--
Y
G
A
H
T
S
I
G
T
L
P
L
V
Y
F
G
T
E
E
Q
K
R
K
Y
L
P
K
L
A
S
G
E
W
I
A
A
Y
C
L
T
E
P
G
S
G
S
D
A
L
A
A
K
T
R
A
T
L
S
E
D
G
K
H
Y
I
L
N
G
V
K
Q
W
I
S
N
A
G
F
A
H
L
F
T
V
F
A
K
V
D
---------
G
---------
E
----
H
-------
F
T
A
F
L
V
E
R
D
T
P
G
L
S
F
G
P
E
E
K
K
M
G
I
K
A
S
S
T
R
Q
V
I
L
E
D
V
K
V
P
V
E
N
V
L
G
E
I
G
K
G
H
K
I
A
F
N
V
L
N
V
G
R
Y
K
L
G
A
G
A
V
G
G
A
K
R
A
L
E
L
S
A
Q
Y
A
T
Q
R
V
Q
F
G
R
P
I
G
R
F
G
L
I
Q
Q
K
L
G
E
M
-----
A
S
R
I
Y
A
A
E
S
A
V
Y
R
T
V
G
L
I
D
E
A
L
L
-----
G
K
K
G
P
E
A
V
M
A
G
I
E
E
Y
A
V
E
A
S
I
I
K
V
L
G
S
E
V
L
D
Y
V
V
D
E
G
V
Q
I
H
G
G
Y
G
Y
S
Q
E
Y
P
I
E
R
A
Y
R
D
A
R
I
N
R
I
F
E
G
T
N
E
I
N
R
L
L
I
P
----------
G
M
L
L
R
R
----------------------------------------
E
-
D
L
-----
E
L
H
Q
--------
V
Q
N
L
K
K
L
A
L
M
V
-
A
G
L
A
V
Q
K
Y
G
Q
G
V
E
E
E
Q
E
V
L
G
A
V
A
D
I
L
I
D
A
Y
A
A
E
S
A
L
L
R
A
R
R
L
---------
G
G
L
A
P
V
L
A
R
I
Y
L
A
Q
A
L
D
R
A
Q
A
G
A
L
S
V
L
P
R
L
V
E
G
D
E
A
R
V
V
Y
S
A
A
R
R
L
T
K
R
E
P
G
-
D
L
V
A
L
R
R
Q
A
A
E
A
V
L
E
A
G
G
Y
P
I
--
101
Fugue
85.57
55%
-77
- C2 -
2Z1Q
2
?
B:
[5-577]
----
K
K
L
W
Q
K
G
G
G
W
L
L
E
V
P
--
E
-
R
V
Y
T
-----
P
E
D
F
D
E
S
V
----
K
E
----
I
A
R
T
T
R
T
F
V
E
R
E
V
L
P
L
L
E
R
M
E
H
-
G
E
L
E
L
N
V
P
L
----
M
R
K
A
G
E
L
G
L
L
A
I
D
V
P
E
E
Y
G
G
L
D
L
P
K
---
V
I
S
T
V
V
A
E
E
L
S
G
-
S
--
G
-
G
-----
F
S
-
V
T
--
Y
G
A
H
T
S
I
G
T
L
P
L
V
Y
F
G
T
E
E
Q
K
R
K
Y
L
P
K
L
A
S
G
E
W
I
A
A
Y
C
L
T
E
P
G
S
G
S
D
A
L
A
A
K
T
R
A
T
L
S
E
D
G
K
H
Y
I
L
N
G
V
K
Q
W
I
S
N
A
G
F
A
H
L
F
T
V
F
A
K
V
D
---------
G
---------
E
----
H
-------
F
T
A
F
L
V
E
R
D
T
P
G
L
S
F
G
P
E
E
K
K
M
G
I
K
A
S
S
T
R
Q
V
I
L
E
D
V
K
V
P
V
E
N
V
L
G
E
I
G
K
G
H
K
I
A
F
N
V
L
N
V
G
R
Y
K
L
G
A
G
A
V
G
G
A
K
R
A
L
E
L
S
A
Q
Y
A
T
Q
R
V
Q
F
G
R
P
I
G
R
F
G
L
I
Q
Q
K
L
G
E
M
-----
A
S
R
I
Y
A
A
E
S
A
V
Y
R
T
V
G
L
I
D
E
A
L
-----
L
G
K
K
G
P
E
A
V
M
A
G
I
E
E
Y
A
V
E
A
S
I
I
K
V
L
G
S
E
V
L
D
Y
V
V
D
E
G
V
Q
I
H
G
G
Y
G
Y
S
Q
E
Y
P
I
E
R
A
Y
R
D
A
R
I
N
R
I
F
E
G
T
N
E
I
N
R
L
L
I
P
----------
G
M
L
L
R
R
A
E
P
E
D
-----------------------------------------------
L
E
L
H
----
Q
V
Q
N
L
K
K
L
A
L
M
V
-
A
G
L
A
V
Q
K
Y
G
Q
G
V
E
E
E
Q
E
V
L
G
A
V
A
D
I
L
I
D
A
Y
A
A
E
S
A
L
L
R
A
R
R
L
G
G
---------
L
A
P
V
L
A
R
I
Y
L
A
Q
A
L
D
R
A
Q
A
G
A
L
S
V
L
P
R
L
V
E
G
D
E
A
R
V
V
Y
S
A
A
R
R
L
T
K
R
E
P
G
-
D
L
V
A
L
R
R
Q
A
A
E
A
V
L
E
A
G
G
Y
P
I
PR
21
PsiBlast_CBE
85.10
54%
-78
- C2 -
2Z1Q
2
?
B:
[9-575]
--------
Q
K
G
G
G
W
L
L
E
--
V
P
E
-
R
V
Y
T
-----
P
E
D
F
D
E
S
V
----
K
E
----
I
A
R
T
T
R
T
F
V
E
R
E
V
L
P
L
L
E
R
M
E
H
-
G
E
L
E
L
N
V
P
L
----
M
R
K
A
G
E
L
G
L
L
A
I
D
V
P
E
E
Y
G
G
L
D
L
P
K
---
V
I
S
T
V
V
A
E
E
L
S
G
-
S
--
G
-
G
-----
F
S
-
V
T
--
Y
G
A
H
T
S
I
G
T
L
P
L
V
Y
F
G
T
E
E
Q
K
R
K
Y
L
P
K
L
A
S
G
E
W
I
A
A
Y
C
L
T
E
P
G
S
G
S
D
A
L
A
A
K
T
R
A
T
L
S
E
D
G
K
H
Y
I
L
N
G
V
K
Q
W
I
S
N
A
G
F
A
H
L
F
T
V
F
A
K
V
D
---------
G
---------
E
----
H
-------
F
T
A
F
L
V
E
R
D
T
P
G
L
S
F
G
P
E
E
K
K
M
G
I
K
A
S
S
T
R
Q
V
I
L
E
D
V
K
V
P
V
E
N
V
L
G
E
I
G
K
G
H
K
I
A
F
N
V
L
N
V
G
R
Y
K
L
G
A
G
A
V
G
G
A
K
R
A
L
E
L
S
A
Q
Y
A
T
Q
R
V
Q
F
G
R
P
I
G
R
F
G
L
I
Q
Q
K
L
G
E
M
-----
A
S
R
I
Y
A
A
E
S
A
V
Y
R
T
V
G
L
I
D
E
A
L
L
-----
G
K
K
G
P
E
A
V
M
A
G
I
E
E
Y
A
V
E
A
S
I
I
K
V
L
G
S
E
V
L
D
Y
V
V
D
E
G
V
Q
I
H
G
G
Y
G
Y
S
Q
E
Y
P
I
E
R
A
Y
R
D
A
R
I
N
R
I
F
E
G
T
N
E
I
N
R
L
L
I
P
----------
G
M
L
L
R
R
A
------------------------------------
E
P
-
E
-
D
L
-----
E
L
H
Q
--------
V
Q
N
L
K
K
L
A
L
M
V
-
A
G
L
A
V
Q
K
Y
G
Q
G
V
E
E
E
Q
E
V
L
G
A
V
A
D
I
L
I
D
A
Y
A
A
E
S
A
L
L
R
A
R
R
L
---------
G
G
L
A
P
V
L
A
R
I
Y
L
A
Q
A
L
D
R
A
Q
A
G
A
L
S
V
L
P
R
L
V
E
G
D
E
A
R
V
V
Y
S
A
A
R
R
L
T
K
R
E
P
G
-
D
L
V
A
L
R
R
Q
A
A
E
A
V
L
E
A
G
G
Y
P
I
--
112
HHSearch
83.78
55%
-59
- C2 -
2Z1Q
2
?
A:
[8-575]
-------
W
Q
K
G
G
G
W
L
L
E
V
P
--
E
-
R
V
Y
T
-----
P
E
D
F
D
E
S
V
----
K
E
----
I
A
R
T
T
R
T
F
V
E
R
E
V
L
P
L
L
E
R
M
E
H
-
G
E
L
E
L
N
V
P
L
----
M
R
K
A
G
E
L
G
L
L
A
I
D
V
P
E
E
Y
G
G
L
D
L
P
K
---
V
I
S
T
V
V
A
E
E
L
S
G
-
S
--
G
-
G
-----
F
S
-
V
T
--
Y
G
A
H
T
S
I
G
T
L
P
L
V
Y
F
G
T
E
E
Q
K
R
K
Y
L
P
K
L
A
S
G
E
W
I
A
A
Y
C
L
T
E
P
G
S
G
S
D
A
L
A
A
K
T
R
A
T
L
S
E
D
G
K
H
Y
I
L
N
G
V
K
Q
W
I
S
N
A
G
F
A
H
L
F
T
V
F
A
K
V
D
---------
G
---------
E
----
H
-------
F
T
A
F
L
V
E
R
D
T
P
G
L
S
F
G
P
E
E
K
K
M
G
I
K
A
S
S
T
R
Q
V
I
L
E
D
V
K
V
P
V
E
N
V
L
G
E
I
G
K
G
H
K
I
A
F
N
V
L
N
V
G
R
Y
K
L
G
A
G
A
V
G
G
A
K
R
A
L
E
L
S
A
Q
Y
A
T
Q
R
V
Q
F
G
R
P
I
G
R
F
G
L
I
Q
Q
K
L
G
E
M
-----
A
S
R
I
Y
A
A
E
S
A
V
Y
R
T
V
G
L
I
D
E
A
L
L
G
K
K
-----
G
P
E
A
V
M
A
G
I
E
E
Y
A
V
E
A
S
I
I
K
V
L
G
S
E
V
L
D
Y
V
V
D
E
G
V
Q
I
H
G
G
Y
G
Y
S
Q
E
Y
P
I
E
R
A
Y
R
D
A
R
I
N
R
I
F
E
G
T
N
E
I
N
R
L
L
I
P
----------
G
M
L
L
R
R
------------------------------------------------------
E
D
L
E
L
H
Q
V
Q
N
L
K
K
L
A
L
M
V
-
A
G
L
A
V
Q
K
Y
G
Q
G
V
E
E
E
Q
E
V
L
G
A
V
A
D
I
L
I
D
A
Y
A
A
E
S
A
L
L
R
A
R
R
L
G
---------
G
L
A
P
V
L
A
R
I
Y
L
A
Q
A
L
D
R
A
Q
A
G
A
L
S
V
L
P
R
L
V
E
G
D
E
A
R
V
V
Y
S
A
A
R
R
L
T
K
R
E
P
G
-
D
L
V
A
L
R
R
Q
A
A
E
A
V
L
E
A
G
G
Y
P
I
--
70
PsiBlast_CBE
51.53
31%
-29
- C2 -
1UDY
4
ACADM_PIG
B:
[15-386]
----------------------------------
E
L
T
E
Q
Q
----
K
E
----
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
-
D
-
R
T
G
E
Y
P
V
P
L
----
L
K
R
A
W
E
L
G
L
M
N
T
H
I
P
E
S
F
G
G
L
G
L
G
I
---
I
D
S
C
L
I
T
E
E
L
A
Y
-
G
--
C
-
T
-----
G
V
-
Q
T
--
A
I
E
A
N
T
L
G
Q
V
P
L
I
I
G
G
N
Y
Q
Q
Q
K
K
Y
L
G
R
M
T
E
E
P
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
--
E
K
K
G
D
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
---------
P
---------
D
----
P
KAPASKA
F
T
G
F
I
V
E
A
D
T
P
G
V
Q
I
G
R
K
E
I
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
G
E
G
A
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
M
-----
A
M
K
V
E
L
A
R
L
S
Y
Q
R
------------
A
A
W
E
I
D
S
G
R
R
N
T
Y
----
Y
A
---
S
I
A
K
A
Y
A
A
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
51.00
31%
-29
- C2 -
1UDY
5
ACADM_PIG
D:
[15-386]
----------------------------------
E
L
T
E
Q
Q
----
K
E
----
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
-
D
-
R
T
G
E
Y
P
V
P
L
----
L
K
R
A
W
E
L
G
L
M
N
T
H
I
P
E
S
F
G
G
L
G
L
G
I
---
I
D
S
C
L
I
T
E
E
L
A
Y
-
G
--
C
-
T
-----
G
V
-
Q
T
--
A
I
E
A
N
T
L
G
Q
V
P
L
I
I
G
G
N
Y
Q
Q
Q
K
K
Y
L
G
R
M
T
E
E
P
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
--
E
K
K
G
D
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
---------
P
---------
D
----
P
KAPASKA
F
T
G
F
I
V
E
A
D
T
P
G
V
Q
I
G
R
K
E
I
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
G
E
G
A
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
M
-----
A
M
K
V
E
L
A
R
L
S
Y
Q
R
------------
A
A
W
E
I
D
S
G
R
R
N
T
Y
----
Y
A
---
S
I
A
K
A
Y
A
A
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
HHSearch
49.95
33%
23
- C2 -
2UXW
4
ACADV_HUMAN
A:
[28-601]
-----------
G
M
F
K
G
Q
-
L
T
T
D
Q
V
F
P
Y
-----
P
S
V
L
N
E
E
Q
----
T
Q
F
L
K
E
L
V
E
P
V
S
R
F
F
E
E
V
N
D
P
A
K
N
--
D
A
-
L
E
-
M
V
E
E
T
T
----
W
Q
G
L
K
E
L
G
A
F
G
L
Q
V
P
S
E
L
G
G
V
G
L
C
N
---
T
Q
Y
A
R
L
V
E
I
V
G
M
H
D
--
L
-
G
-----
V
G
-
I
T
--
L
G
A
H
Q
S
I
G
F
K
G
I
L
L
F
G
T
K
A
Q
K
E
K
Y
L
P
K
L
A
S
G
E
T
V
A
A
F
C
L
T
E
P
S
S
G
S
D
A
A
S
I
R
T
S
A
V
P
S
P
C
G
K
Y
Y
T
L
N
G
S
K
L
W
I
S
N
G
G
L
A
D
I
F
T
V
F
A
K
T
P
---------
V
T
D
PATG
A
V
K
E
----
K
-------
I
T
A
F
V
V
E
R
G
F
G
G
I
T
H
G
P
P
E
K
K
M
G
I
K
A
S
N
T
A
E
V
F
F
D
G
V
R
V
P
S
E
N
V
L
G
E
V
G
S
G
F
K
V
A
M
H
I
L
N
N
G
R
F
G
M
A
A
A
L
A
G
T
M
R
G
I
I
A
K
A
V
D
H
A
T
N
R
T
Q
F
G
E
K
I
H
N
F
G
L
I
Q
E
K
L
A
R
M
-----
V
M
L
Q
Y
V
T
E
S
M
A
Y
M
V
S
A
N
M
D
Q
G
A
------------------
T
D
F
Q
I
E
A
A
I
S
K
I
F
G
S
E
A
A
W
K
V
T
D
E
C
I
Q
I
M
G
G
M
G
F
M
K
E
P
G
V
E
R
V
L
R
D
L
R
I
F
R
I
F
E
G
T
N
D
I
L
R
L
F
V
A
----------
L
Q
G
C
M
D
K
G
K
E
L
--
S
G
L
G
S
A
L
K
N
P
FG--------------
S
GLS
L
S
G
L
V
H
P
-----
E
L
S
R
S
G
E
----
L
A
V
R
A
L
E
Q
F
A
T
V
-
V
E
A
K
L
I
K
H
K
K
G
I
V
N
E
Q
F
L
L
Q
R
L
A
D
G
A
I
D
L
Y
A
M
V
V
V
L
S
R
A
S
R
S
L
S
E
-
G
H
P
-
T
A
Q
H
E
K
M
L
C
D
T
W
C
I
E
A
A
A
R
I
R
E
G
M
A
A
L
Q
----
S
D
----------------
P
W
Q
Q
E
L
Y
R
N
F
K
S
I
S
K
A
L
V
E
R
G
G
V
V
T
--
72
PsiBlast_CBE
49.93
31%
-26
- C2 -
3MDE
4
ACADM_PIG
B:
[5-376]
----------------------------------
E
L
T
E
Q
Q
----
K
E
----
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
R
-
T
G
-
E
Y
P
V
P
L
----
L
K
R
A
W
E
L
G
L
M
N
T
H
I
P
E
S
F
G
G
L
G
L
G
I
---
I
D
S
C
L
I
T
E
E
L
A
Y
-
G
--
C
-
T
-----
G
V
-
Q
T
--
A
I
E
A
N
T
L
G
Q
V
P
L
I
I
G
G
N
Y
Q
Q
Q
K
K
Y
L
G
R
M
T
E
E
P
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
--
E
K
K
G
D
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
---------
P
---------
D
----
P
KAPASKA
F
T
G
F
I
V
E
A
D
T
P
G
V
Q
I
G
R
K
E
I
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
G
E
G
A
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
M
-----
A
M
K
V
E
L
A
R
L
S
Y
Q
R
------------
A
A
W
E
I
D
S
G
R
R
N
T
Y
----
Y
A
---
S
I
A
K
A
Y
A
A
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
49.36
31%
-28
- C2 -
1UDY
5
ACADM_PIG
A:
[15-386]
----------------------------------
E
L
T
E
Q
Q
----
K
E
----
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
-
D
-
R
T
G
E
Y
P
V
P
L
----
L
K
R
A
W
E
L
G
L
M
N
T
H
I
P
E
S
F
G
G
L
G
L
G
I
---
I
D
S
C
L
I
T
E
E
L
A
Y
-
G
--
C
-
T
-----
G
V
-
Q
T
--
A
I
E
A
N
T
L
G
Q
V
P
L
I
I
G
G
N
Y
Q
Q
Q
K
K
Y
L
G
R
M
T
E
E
P
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
--
E
K
K
G
D
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
---------
P
---------
D
----
P
KAPASKA
F
T
G
F
I
V
E
A
D
T
P
G
V
Q
I
G
R
K
E
I
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
G
E
G
A
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
M
-----
A
M
K
V
E
L
A
R
L
S
Y
Q
R
------------
A
A
W
E
I
D
S
G
R
R
N
T
Y
----
Y
A
---
S
I
A
K
A
Y
A
A
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
48.70
31%
-34
- C2 -
1RX0
12
ACAD8_HUMAN
D:
[19-393]
-----------------------------------
L
N
E
E
Q
----
K
E
----
F
Q
K
V
A
F
D
F
A
A
R
E
M
A
P
N
M
A
E
W
D
Q
-
K
E
L
-
F
P
V
D
V
----
M
R
K
A
A
Q
L
G
F
G
G
V
Y
I
Q
T
D
V
G
G
S
G
L
S
R
---
L
D
T
S
V
I
F
E
A
L
A
T
-
G
--
C
-
T
-----
S
T
-
T
A
--
Y
I
S
I
H
N
M
C
A
W
M
I
D
S
F
G
N
E
E
Q
R
H
K
F
C
P
P
L
C
T
M
E
K
F
A
S
Y
C
L
T
E
P
G
S
G
S
D
A
A
S
L
L
T
S
A
--
K
K
Q
G
D
H
Y
I
L
N
G
S
K
A
F
I
S
G
A
G
E
S
D
I
Y
V
V
M
C
R
T
G
---------
G
PGP------
K
----
G
-------
I
S
C
I
V
V
E
K
G
T
P
G
L
S
F
G
K
K
E
K
K
V
G
W
N
S
Q
P
T
R
A
V
I
F
E
D
C
A
V
P
V
A
N
R
I
G
S
E
G
Q
G
F
L
I
A
V
R
G
L
N
G
G
R
I
N
I
A
S
C
S
L
G
A
A
H
A
S
V
I
L
T
R
D
H
L
N
V
R
K
Q
F
G
E
P
L
A
S
N
Q
Y
L
Q
F
T
L
A
D
M
-----
A
T
R
L
V
A
A
R
--------
L
M
V
R
N
A
A
V
A
L
Q
E
E
R
K
D
A
V
A
L
----------
C
S
M
A
K
L
F
A
T
D
E
C
F
A
I
C
N
Q
A
L
Q
M
H
G
G
Y
G
Y
L
K
D
Y
A
V
Q
Q
Y
V
R
D
S
R
V
H
Q
I
L
E
G
S
N
E
V
M
R
I
L
I
S
----------
R
S
L
L
Q
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
47.80
31%
-34
- C2 -
1RX0
9
ACAD8_HUMAN
C:
[19-393]
-----------------------------------
L
N
E
E
Q
----
K
E
----
F
Q
K
V
A
F
D
F
A
A
R
E
M
A
P
N
M
A
E
W
D
Q
-
K
E
L
-
F
P
V
D
V
----
M
R
K
A
A
Q
L
G
F
G
G
V
Y
I
Q
T
D
V
G
G
S
G
L
S
R
---
L
D
T
S
V
I
F
E
A
L
A
T
-
G
--
C
-
T
-----
S
T
-
T
A
--
Y
I
S
I
H
N
M
C
A
W
M
I
D
S
F
G
N
E
E
Q
R
H
K
F
C
P
P
L
C
T
M
E
K
F
A
S
Y
C
L
T
E
P
G
S
G
S
D
A
A
S
L
L
T
S
A
--
K
K
Q
G
D
H
Y
I
L
N
G
S
K
A
F
I
S
G
A
G
E
S
D
I
Y
V
V
M
C
R
T
G
---------
G
PGP------
K
----
G
-------
I
S
C
I
V
V
E
K
G
T
P
G
L
S
F
G
K
K
E
K
K
V
G
W
N
S
Q
P
T
R
A
V
I
F
E
D
C
A
V
P
V
A
N
R
I
G
S
E
G
Q
G
F
L
I
A
V
R
G
L
N
G
G
R
I
N
I
A
S
C
S
L
G
A
A
H
A
S
V
I
L
T
R
D
H
L
N
V
R
K
Q
F
G
E
P
L
A
S
N
Q
Y
L
Q
F
T
L
A
D
M
-----
A
T
R
L
V
A
A
R
--------
L
M
V
R
N
A
A
V
A
L
Q
E
E
R
K
D
A
V
A
L
----------
C
S
M
A
K
L
F
A
T
D
E
C
F
A
I
C
N
Q
A
L
Q
M
H
G
G
Y
G
Y
L
K
D
Y
A
V
Q
Q
Y
V
R
D
S
R
V
H
Q
I
L
E
G
S
N
E
V
M
R
I
L
I
S
----------
R
S
L
L
Q
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
47.78
31%
-25
- C2 -
3MDD
2
ACADM_PIG
B:
[5-376]
----------------------------------
E
L
T
E
Q
Q
----
K
E
----
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
R
-
T
G
-
E
Y
P
V
P
L
----
L
K
R
A
W
E
L
G
L
M
N
T
H
I
P
E
S
F
G
G
L
G
L
G
I
---
I
D
S
C
L
I
T
E
E
L
A
Y
-
G
--
C
-
T
-----
G
V
-
Q
T
--
A
I
E
A
N
T
L
G
Q
V
P
L
I
I
G
G
N
Y
Q
Q
Q
K
K
Y
L
G
R
M
T
E
E
P
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
--
E
K
K
G
D
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
---------
P
---------
D
----
P
KAPASKA
F
T
G
F
I
V
E
A
D
T
P
G
V
Q
I
G
R
K
E
I
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
G
E
G
A
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
M
-----
A
M
K
V
E
L
A
R
L
S
Y
Q
R
------------
A
A
W
E
I
D
S
G
R
R
N
T
Y
----
Y
A
---
S
I
A
K
A
Y
A
A
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
47.66
31%
-25
- C2 -
3MDE
3
ACADM_PIG
A:
[5-376]
----------------------------------
E
L
T
E
Q
Q
----
K
E
----
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
R
-
T
G
-
E
Y
P
V
P
L
----
L
K
R
A
W
E
L
G
L
M
N
T
H
I
P
E
S
F
G
G
L
G
L
G
I
---
I
D
S
C
L
I
T
E
E
L
A
Y
-
G
--
C
-
T
-----
G
V
-
Q
T
--
A
I
E
A
N
T
L
G
Q
V
P
L
I
I
G
G
N
Y
Q
Q
Q
K
K
Y
L
G
R
M
T
E
E
P
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
--
E
K
K
G
D
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
---------
P
---------
D
----
P
KAPASKA
F
T
G
F
I
V
E
A
D
T
P
G
V
Q
I
G
R
K
E
I
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
G
E
G
A
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
M
-----
A
M
K
V
E
L
A
R
L
S
Y
Q
R
------------
A
A
W
E
I
D
S
G
R
R
N
T
Y
----
Y
A
---
S
I
A
K
A
Y
A
A
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
Fugue
47.64
32%
31
- C2 -
2UXW
4
ACADV_HUMAN
A:
[21-607]
-----
Q
S
M
S
F
A
V
G
M
F
K
G
Q
L
T
T
D
-
Q
V
F
P
YPSVL
N
E
E
Q
T
Q
F
L
----
K
E
----
L
V
E
P
V
S
R
F
F
E
E
V
N
D
P
A
K
N
D
A
L
E
-
M
V
---
E
E
T
T
----
W
Q
G
L
K
E
L
G
A
F
G
L
Q
V
P
S
E
L
G
G
V
G
L
C
N
---
T
Q
Y
A
R
L
V
E
I
V
G
M
-
H
D-
L
-
G
-----
V
G
-
I
T
--
L
G
A
H
Q
S
I
G
F
K
G
I
L
L
F
G
T
K
A
Q
K
E
K
Y
L
P
K
L
A
S
G
E
T
V
A
A
F
C
L
T
E
P
S
S
G
S
D
A
A
S
I
R
T
S
A
V
P
S
P
C
G
K
Y
Y
T
L
N
G
S
K
L
W
I
S
N
G
G
L
A
D
I
F
T
V
F
A
K
T
P
---------
V
T
D
PATG
A
V
K
E
----
K
-------
I
T
A
F
V
V
E
R
G
F
G
G
I
T
H
G
P
P
E
K
K
M
G
I
K
A
S
N
T
A
E
V
F
F
D
G
V
R
V
P
S
E
N
V
L
G
E
V
G
S
G
F
K
V
A
M
H
I
L
N
N
G
R
F
G
M
A
A
A
L
A
G
T
M
R
G
I
I
A
K
A
V
D
H
A
T
N
R
T
Q
F
G
E
K
I
H
N
F
G
L
I
Q
E
K
L
A
R
M
-----
V
M
L
Q
Y
V
T
E
S
M
A
Y
M
V
S
A
N
M
D
Q
G
A
T
------------------
D
F
Q
I
E
A
A
I
S
K
I
F
G
S
E
A
A
W
K
V
T
D
E
C
I
Q
I
M
G
G
M
G
F
M
K
E
P
G
V
E
R
V
L
R
D
L
R
I
F
R
I
F
E
G
T
N
D
I
L
R
L
F
V
A
----------
L
Q
G
C
M
D
K
G
K
E
L
--
S
G
L
G
S
A
L
K
N
P
--
F
G
S
-----
G
L
S
L
--
S
---
G
L
-
V
-
H
P
-----
E
L
S
R
S
G
E
----
L
A
V
R
A
L
E
Q
F
A
T
V
-
V
E
A
K
L
I
K
H
K
K
G
I
V
N
E
Q
F
L
L
Q
R
L
A
D
G
A
I
D
L
Y
A
M
V
V
V
L
S
R
A
S
R
S
L
S
E
--
G
H
P
T
A
Q
H
E
K
M
L
C
D
T
W
C
I
E
A
A
A
R
I
R
E
G
M
A
A
L
Q
----
S
D
P
W
Q
Q
E
L
Y
R
N
F
K
S
I
S
K
A
L
V
E
-
R
---------
G
G
V
V
T
S
N
P
L
G
F
--
37
PsiBlast_CBE
47.31
31%
-34
- C2 -
1RX0
10
ACAD8_HUMAN
B:
[19-393]
-----------------------------------
L
N
E
E
Q
----
K
E
----
F
Q
K
V
A
F
D
F
A
A
R
E
M
A
P
N
M
A
E
W
D
Q
-
K
E
L
-
F
P
V
D
V
----
M
R
K
A
A
Q
L
G
F
G
G
V
Y
I
Q
T
D
V
G
G
S
G
L
S
R
---
L
D
T
S
V
I
F
E
A
L
A
T
-
G
--
C
-
T
-----
S
T
-
T
A
--
Y
I
S
I
H
N
M
C
A
W
M
I
D
S
F
G
N
E
E
Q
R
H
K
F
C
P
P
L
C
T
M
E
K
F
A
S
Y
C
L
T
E
P
G
S
G
S
D
A
A
S
L
L
T
S
A
--
K
K
Q
G
D
H
Y
I
L
N
G
S
K
A
F
I
S
G
A
G
E
S
D
I
Y
V
V
M
C
R
T
G
---------
G
PGP------
K
----
G
-------
I
S
C
I
V
V
E
K
G
T
P
G
L
S
F
G
K
K
E
K
K
V
G
W
N
S
Q
P
T
R
A
V
I
F
E
D
C
A
V
P
V
A
N
R
I
G
S
E
G
Q
G
F
L
I
A
V
R
G
L
N
G
G
R
I
N
I
A
S
C
S
L
G
A
A
H
A
S
V
I
L
T
R
D
H
L
N
V
R
K
Q
F
G
E
P
L
A
S
N
Q
Y
L
Q
F
T
L
A
D
M
-----
A
T
R
L
V
A
A
R
--------
L
M
V
R
N
A
A
V
A
L
Q
E
E
R
K
D
A
V
A
L
----------
C
S
M
A
K
L
F
A
T
D
E
C
F
A
I
C
N
Q
A
L
Q
M
H
G
G
Y
G
Y
L
K
D
Y
A
V
Q
Q
Y
V
R
D
S
R
V
H
Q
I
L
E
G
S
N
E
V
M
R
I
L
I
S
----------
R
S
L
L
Q
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
47.19
31%
-27
- C2 -
1UDY
4
ACADM_PIG
C:
[15-386]
----------------------------------
E
L
T
E
Q
Q
----
K
E
----
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
-
D
-
R
T
G
E
Y
P
V
P
L
----
L
K
R
A
W
E
L
G
L
M
N
T
H
I
P
E
S
F
G
G
L
G
L
G
I
---
I
D
S
C
L
I
T
E
E
L
A
Y
-
G
--
C
-
T
-----
G
V
-
Q
T
--
A
I
E
A
N
T
L
G
Q
V
P
L
I
I
G
G
N
Y
Q
Q
Q
K
K
Y
L
G
R
M
T
E
E
P
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
--
E
K
K
G
D
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
---------
P
---------
D
----
P
KAPASKA
F
T
G
F
I
V
E
A
D
T
P
G
V
Q
I
G
R
K
E
I
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
G
E
G
A
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
M
-----
A
M
K
V
E
L
A
R
L
S
Y
Q
R
------------
A
A
W
E
I
D
S
G
R
R
N
T
Y
----
Y
A
---
S
I
A
K
A
Y
A
A
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
47.04
31%
-26
- C2 -
3MDD
2
ACADM_PIG
A:
[5-376]
----------------------------------
E
L
T
E
Q
Q
----
K
E
----
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
R
-
T
G
-
E
Y
P
V
P
L
----
L
K
R
A
W
E
L
G
L
M
N
T
H
I
P
E
S
F
G
G
L
G
L
G
I
---
I
D
S
C
L
I
T
E
E
L
A
Y
-
G
--
C
-
T
-----
G
V
-
Q
T
--
A
I
E
A
N
T
L
G
Q
V
P
L
I
I
G
G
N
Y
Q
Q
Q
K
K
Y
L
G
R
M
T
E
E
P
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
--
E
K
K
G
D
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
---------
P
---------
D
----
P
KAPASKA
F
T
G
F
I
V
E
A
D
T
P
G
V
Q
I
G
R
K
E
I
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
G
E
G
A
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
M
-----
A
M
K
V
E
L
A
R
L
S
Y
Q
R
------------
A
A
W
E
I
D
S
G
R
R
N
T
Y
----
Y
A
---
S
I
A
K
A
Y
A
A
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
HHSearch
46.95
34%
-26
- C2 -
2PG0
2
?
A:
[7-383]
--------------------------------
A
R
Y
L
R
E
E
H
----
H
M
----
F
R
A
A
F
R
K
F
L
E
K
E
A
Y
P
H
Y
N
D
W
E
K
-
R
G
-
I
I
P
R
S
F
----
W
A
K
M
G
E
N
G
F
L
C
P
W
V
D
E
K
Y
G
G
L
N
A
D
F
---
A
Y
S
V
V
I
N
E
E
L
E
K
V
G
--
S
-
S
-----
L
V
-
G
---
I
G
L
H
N
D
I
V
T
P
Y
I
A
S
Y
G
T
E
E
Q
K
Q
K
W
L
P
K
C
V
T
G
E
L
I
T
A
I
A
M
T
E
P
G
A
G
S
D
L
A
N
I
S
T
T
A
V
K
D
--
G
D
Y
Y
I
V
N
G
Q
K
T
F
I
T
N
G
I
H
A
D
L
I
V
V
A
C
K
T
D
---------
P
QAKPPH---
R
----
G
-------
I
S
L
L
V
V
E
R
D
T
P
G
F
T
R
G
R
K
L
E
K
V
G
L
H
A
Q
D
T
A
E
L
F
F
Q
D
A
K
V
P
A
Y
N
L
L
G
E
E
G
K
G
F
Y
Y
L
M
E
K
L
Q
Q
E
R
L
V
V
A
I
A
A
Q
T
A
A
E
V
M
F
S
L
T
K
Q
Y
V
K
Q
R
T
A
F
G
K
R
V
S
E
F
Q
T
V
Q
F
R
L
A
E
M
-----
A
T
E
I
A
L
G
R
T
F
V
D
R
V
I
E
E
H
M
A
G
-------------------
K
Q
I
V
T
E
V
S
M
A
K
W
W
I
T
E
M
A
K
R
V
A
A
E
A
M
Q
L
H
G
G
Y
G
Y
M
E
E
Y
E
I
A
R
R
Y
R
D
I
P
V
S
A
I
Y
A
G
T
N
E
M
M
K
T
I
I
A
----------
R
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
45.97
34%
26
- C2 -
3B96
2
ACADV_HUMAN
A:
[8-554]
------------
G
M
F
K
G
Q
L
T
T
D
-
Q
V
F
P
Y----
P
S
V
L
N
E
E
Q
T
Q
F
L
K
E
----
L
V
E
P
V
S
R
F
F
E
E
V
N
D
P
A
K
N
D
A
L
E
-
M
V
E
E
T
T
W
Q
G
----
L
K
---
E
L
G
A
F
G
L
Q
V
P
S
E
L
G
G
V
G
L
C
N
---
T
Q
Y
A
R
L
V
E
I
V
G
M
-
H
--
D
L
G
-----
V
G
-
I
T
--
L
G
A
H
Q
S
I
G
F
K
G
I
L
L
F
G
T
K
A
Q
K
E
K
Y
L
P
K
L
A
S
G
E
T
V
A
A
F
C
L
T
E
P
S
S
G
S
D
A
A
S
I
R
T
S
A
V
P
S
P
C
G
K
Y
Y
T
L
N
G
S
K
L
W
I
S
N
G
G
L
A
D
I
F
T
V
F
A
K
T
P
V
T
D
PATG
A
V
K
---------
E
----
K
-------
I
T
A
F
V
V
E
R
G
F
G
G
I
T
H
G
P
P
E
K
K
M
G
I
K
A
S
N
T
A
E
V
F
F
D
G
V
R
V
P
S
E
N
V
L
G
E
V
G
S
G
F
K
V
A
M
H
I
L
N
N
G
R
F
G
M
A
A
A
L
A
G
T
M
R
G
I
I
A
K
A
V
D
H
A
T
N
R
T
Q
F
G
E
K
I
H
N
F
G
L
I
Q
E
K
L
A
R
M
-----
V
M
L
Q
Y
V
T
E
S
M
A
Y
----
M
V
S
A
N
M
D
Q
--------------
G
A
T
D
F
Q
I
E
A
A
I
S
K
I
F
G
S
E
A
A
W
K
V
T
D
E
C
I
Q
I
M
G
G
M
G
F
M
K
E
P
G
V
E
R
V
L
R
D
L
R
I
F
R
I
F
E
G
T
N
D
I
L
R
L
F
V
A
L
Q
G
C
M
D
K
G
K
E
L
S
--------------------------LSL--
S
G
L
V
H
P
E
---
L
S
-
R
-
S
G
E
L
A
V
R
A
L
E
Q
F
A
T
----
V
V
-
E
A
K
L
I
-----------
K
H
K
K
G
I
V
N
E
Q
F
L
L
Q
R
L
A
D
G
A
I
D
L
Y
A
M
V
V
V
L
S
R
A
S
R
S
L
-
S
-
E
G
H
P
T
A
Q
H
E
K
M
L
C
D
T
W
C
I
E
A
----
A
A
R
I
R
E
G
M
A
A
L
Q
---------------------------------------------
100
PsiBlast_CBE
45.69
34%
-16
- C2 -
2DVL
2
?
B:
[3-366]
-----------------------------------
L
T
Q
E
Q
----
R
L
----
V
L
D
A
V
R
R
-
V
A
R
E
V
L
Y
P
L
A
P
E
Y
D
-
R
K
A
E
Y
P
W
P
Q
----
L
K
A
L
A
E
L
G
L
L
G
M
T
T
P
E
E
W
G
G
V
G
L
D
S
---
V
T
W
A
L
A
L
E
E
L
A
A
-
A
--
D
P
S
-----
V
A
-
V
I
--
V
S
V
T
S
G
L
P
Q
Y
M
L
L
R
F
G
S
E
A
Q
K
R
R
Y
L
V
P
L
A
R
G
E
W
I
G
A
F
C
L
T
E
P
Q
A
G
S
D
A
K
S
L
R
A
E
A
R
R
V
K
G
G
--
F
V
L
N
G
V
K
S
W
I
T
S
A
G
H
A
H
L
Y
V
V
M
A
R
T
E
-------------------
K
----
G
-------
I
S
A
F
L
V
E
K
G
T
P
G
L
S
F
G
R
P
E
E
K
M
G
L
H
A
A
H
T
A
E
V
R
L
E
E
V
F
V
P
E
E
N
L
L
G
E
E
G
R
G
L
A
Y
A
L
A
G
L
D
S
G
R
V
G
V
A
A
Q
A
V
G
I
A
R
G
A
F
E
I
A
K
A
Y
A
E
E
R
E
Q
F
G
K
K
L
K
E
H
Q
A
I
A
F
K
I
A
D
M
-----
H
V
K
I
A
A
A
R
A
L
V
L
E
A
-
A
R
K
K
D
R
G
E
R
F
T
L
E
A
S
A
A
K
L
F
A
S
A
A
A
V
E
------------------
V
T
R
E
A
V
Q
V
L
G
G
Y
G
Y
H
R
D
Y
R
V
E
R
Y
Y
R
D
A
K
V
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
45.49
33%
-22
- C2 -
2PG0
2
?
A:
[12-379]
-------------------------------------
E
E
H
----
H
M
----
F
R
A
A
F
R
K
F
L
E
K
E
A
Y
P
H
Y
N
D
W
E
K
-
R
G
I
I
P
R
-
S
F
----
W
A
K
M
G
E
N
G
F
L
C
P
W
V
D
E
K
Y
G
G
L
N
A
D
F
---
A
Y
S
V
V
I
N
E
E
L
E
K
-
V
--
G
-
S
-----
S
L
-
V
G
--
I
G
L
H
N
D
I
V
T
P
Y
I
A
S
Y
G
T
E
E
Q
K
Q
K
W
L
P
K
C
V
T
G
E
L
I
T
A
I
A
M
T
E
P
G
A
G
S
D
L
A
N
I
S
T
T
A
V
K
D
--
G
D
Y
Y
I
V
N
G
Q
K
T
F
I
T
N
G
I
H
A
D
L
I
V
V
A
C
K
T
D
---------
P
---------
Q
----
A
KPPHRG-
I
S
L
L
V
V
E
R
D
T
P
G
F
T
R
G
R
K
L
E
K
V
G
L
H
A
Q
D
T
A
E
L
F
F
Q
D
A
K
V
P
A
Y
N
L
L
G
E
E
G
K
G
F
Y
Y
L
M
E
K
L
Q
Q
E
R
L
V
V
A
I
A
A
Q
T
A
A
E
V
M
F
S
L
T
K
Q
Y
V
K
Q
R
T
A
F
G
K
R
V
S
E
F
Q
T
V
Q
F
R
L
A
E
M
-----
A
T
E
I
A
L
G
R
T
F
V
D
R
V
I
---
E
E
H
M
A
---------
G
K
Q
I
-------
V
T
E
V
S
M
A
K
W
W
I
T
E
M
A
K
R
V
A
A
E
A
M
Q
L
H
G
G
Y
G
Y
M
E
E
Y
E
I
A
R
R
Y
R
D
I
P
V
S
A
I
Y
A
G
T
N
E
M
M
K
T
I
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
45.27
34%
31
- C2 -
2UXW
4
ACADV_HUMAN
A:
[28-574]
------------
G
M
F
K
G
Q
L
T
T
D
-
Q
V
F
P
Y----
P
S
V
L
N
E
E
Q
T
Q
F
L
K
E
----
L
V
E
P
V
S
R
F
F
E
E
V
N
D
P
A
K
N
D
A
L
E
-
M
V
E
E
T
T
W
Q
G
----
L
K
---
E
L
G
A
F
G
L
Q
V
P
S
E
L
G
G
V
G
L
C
N
---
T
Q
Y
A
R
L
V
E
I
V
G
M
-
H
--
D
L
G
-----
V
G
-
I
T
--
L
G
A
H
Q
S
I
G
F
K
G
I
L
L
F
G
T
K
A
Q
K
E
K
Y
L
P
K
L
A
S
G
E
T
V
A
A
F
C
L
T
E
P
S
S
G
S
D
A
A
S
I
R
T
S
A
V
P
S
P
C
G
K
Y
Y
T
L
N
G
S
K
L
W
I
S
N
G
G
L
A
D
I
F
T
V
F
A
K
T
P
V
T
D
PATG
A
V
K
---------
E
----
K
-------
I
T
A
F
V
V
E
R
G
F
G
G
I
T
H
G
P
P
E
K
K
M
G
I
K
A
S
N
T
A
E
V
F
F
D
G
V
R
V
P
S
E
N
V
L
G
E
V
G
S
G
F
K
V
A
M
H
I
L
N
N
G
R
F
G
M
A
A
A
L
A
G
T
M
R
G
I
I
A
K
A
V
D
H
A
T
N
R
T
Q
F
G
E
K
I
H
N
F
G
L
I
Q
E
K
L
A
R
M
-----
V
M
L
Q
Y
V
T
E
S
M
A
Y
----
M
V
S
A
N
M
D
Q
--------------
G
A
T
D
F
Q
I
E
A
A
I
S
K
I
F
G
S
E
A
A
W
K
V
T
D
E
C
I
Q
I
M
G
G
M
G
F
M
K
E
P
G
V
E
R
V
L
R
D
L
R
I
F
R
I
F
E
G
T
N
D
I
L
R
L
F
V
A
L
Q
G
C
M
D
K
G
K
E
L
S
G
L
G
S
A
L
K
N
P
FG---------------SGLSL
S
G
L
V
H
P
E
---
L
S
-
R
-
S
G
E
L
A
V
R
A
L
E
Q
F
A
T
----
V
V
-
E
A
K
L
I
-----------
K
H
K
K
G
I
V
N
E
Q
F
L
L
Q
R
L
A
D
G
A
I
D
L
Y
A
M
V
V
V
L
S
R
A
S
R
S
L
-
S
-
E
G
H
P
T
A
Q
H
E
K
M
L
C
D
T
W
C
I
E
A
----
A
A
R
I
R
E
G
M
A
A
L
Q
---------------------------------------------
53
PsiBlast_CBE
45.03
33%
-22
- C2 -
2PG0
2
?
B:
[12-379]
-------------------------------------
E
E
H
----
H
M
----
F
R
A
A
F
R
K
F
L
E
K
E
A
Y
P
H
Y
N
D
W
E
K
-
R
G
I
I
P
R
-
S
F
----
W
A
K
M
G
E
N
G
F
L
C
P
W
V
D
E
K
Y
G
G
L
N
A
D
F
---
A
Y
S
V
V
I
N
E
E
L
E
K
-
V
--
G
-
S
-----
S
L
-
V
G
--
I
G
L
H
N
D
I
V
T
P
Y
I
A
S
Y
G
T
E
E
Q
K
Q
K
W
L
P
K
C
V
T
G
E
L
I
T
A
I
A
M
T
E
P
G
A
G
S
D
L
A
N
I
S
T
T
A
V
K
D
--
G
D
Y
Y
I
V
N
G
Q
K
T
F
I
T
N
G
I
H
A
D
L
I
V
V
A
C
K
T
D
---------
P
---------
Q
----
A
KPPHRG-
I
S
L
L
V
V
E
R
D
T
P
G
F
T
R
G
R
K
L
E
K
V
G
L
H
A
Q
D
T
A
E
L
F
F
Q
D
A
K
V
P
A
Y
N
L
L
G
E
E
G
K
G
F
Y
Y
L
M
E
K
L
Q
Q
E
R
L
V
V
A
I
A
A
Q
T
A
A
E
V
M
F
S
L
T
K
Q
Y
V
K
Q
R
T
A
F
G
K
R
V
S
E
F
Q
T
V
Q
F
R
L
A
E
M
-----
A
T
E
I
A
L
G
R
T
F
V
D
R
V
I
---
E
E
H
M
A
---------
G
K
Q
I
-------
V
T
E
V
S
M
A
K
W
W
I
T
E
M
A
K
R
V
A
A
E
A
M
Q
L
H
G
G
Y
G
Y
M
E
E
Y
E
I
A
R
R
Y
R
D
I
P
V
S
A
I
Y
A
G
T
N
E
M
M
K
T
I
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
43.25
32%
16
- C2 -
1BUC
3
ACDS_MEGEL
B:
[4-383]
----------------------------------
N
L
T
D
I
Q
----
Q
D
----
F
L
K
L
A
H
D
F
G
E
K
K
L
A
P
T
V
T
E
-
R
D
-
H
K
G
I
Y
D
K
E
L
----
I
D
E
L
L
S
L
G
I
T
G
A
Y
F
E
E
K
Y
G
G
S
G
D
D
G
GDV
L
S
Y
I
L
A
V
E
E
L
A
K
Y
D
--
A
-
G
-----
V
A
-
I
T
--
L
S
A
T
V
S
L
C
A
N
P
I
W
Q
F
G
T
E
A
Q
K
E
K
F
L
V
P
L
V
E
G
T
K
L
G
A
F
G
L
T
E
P
N
A
G
T
D
A
S
G
Q
Q
T
I
A
T
K
N
D
D
G
T
-
Y
T
L
N
G
S
K
I
F
I
T
N
G
G
A
A
D
I
Y
I
V
F
A
M
T
D
---------
K
---------
S
----
K
GNHG---
I
T
A
F
I
L
E
D
G
T
P
G
F
T
Y
G
K
K
E
D
K
M
G
I
H
T
S
Q
T
M
E
L
V
F
Q
D
V
K
V
P
A
E
N
M
L
G
E
E
G
K
G
F
K
I
A
M
M
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
A
D
A
V
E
Y
S
K
Q
R
V
Q
F
G
K
P
L
C
K
F
Q
S
I
S
F
K
L
A
D
M
-----
K
M
Q
I
E
A
A
R
N
L
V
Y
K
------------
A
A
C
K
K
Q
E
G
K
-------
P
F
T
V
D
A
A
I
A
K
R
V
A
S
D
V
A
M
R
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
E
V
Q
L
M
V
T
G
----------
G
A
L
L
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
42.15
33%
-4
- C2 -
1UKW
3
?
B:
[4-377]
----------------------------------
S
L
T
E
E
Q
----
R
Q
----
L
Q
A
L
A
R
R
F
A
K
E
V
I
L
P
V
A
Q
E
Y
D
E
-
K
E
-
E
V
P
W
P
V
----
I
E
K
L
H
E
V
G
L
L
N
A
I
I
P
E
E
Y
G
G
M
G
L
K
M
---
L
D
E
V
I
V
G
E
E
L
A
Y
-
A
CM
G
-
I
-----
Y
T
-
I
P
--
M
A
S
D
L
G
I
--
T
P
V
L
L
A
G
T
E
E
Q
K
E
R
F
L
R
P
L
T
E
K
P
A
L
A
A
F
A
L
S
E
P
G
N
G
S
D
A
A
A
L
K
T
R
A
I
--
R
Q
G
D
H
Y
V
L
N
G
T
K
M
W
I
S
N
G
G
E
A
E
W
V
V
V
F
A
T
V
N
---------
P
---------
E
LRHK
G
-------
V
V
A
L
V
V
E
R
G
T
P
G
F
K
A
I
K
I
H
G
K
M
G
Q
R
A
S
G
T
Y
E
L
V
F
E
D
V
K
V
P
V
E
N
R
L
G
E
E
G
E
G
F
K
I
A
M
Q
T
L
N
K
T
R
I
P
V
A
A
G
S
V
G
V
A
R
R
A
L
D
E
A
R
K
Y
A
K
E
R
E
A
F
G
E
P
I
A
N
F
Q
A
I
Q
F
K
L
V
D
M
------------------
L
I
G
I
E
T
A
R
M
Y
T
Y
Y
A
A
W
L
A
D
------
Q
G
L
P
H
A
H
A
S
A
I
A
K
A
Y
A
S
E
I
A
F
E
A
A
N
Q
A
I
Q
I
H
G
G
Y
G
Y
V
R
E
F
P
V
E
K
L
L
R
D
V
K
L
N
Q
I
Y
E
G
T
N
E
I
Q
R
L
I
I
A
----------
R
H
I
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
41.58
33%
-5
- C2 -
1UKW
2
?
A:
[4-377]
----------------------------------
S
L
T
E
E
Q
----
R
Q
----
L
Q
A
L
A
R
R
F
A
K
E
V
I
L
P
V
A
Q
E
Y
D
E
-
K
E
-
E
V
P
W
P
V
----
I
E
K
L
H
E
V
G
L
L
N
A
I
I
P
E
E
Y
G
G
M
G
L
K
M
---
L
D
E
V
I
V
G
E
E
L
A
Y
-
A
C
M
G
-
I
-----
Y
T
-
I
P
--
M
A
S
D
L
G
I
--
T
P
V
L
L
A
G
T
E
E
Q
K
E
R
F
L
R
P
L
T
E
K
P
A
L
A
A
F
A
L
S
E
P
G
N
G
S
D
A
A
A
L
K
T
R
A
I
--
R
Q
G
D
H
Y
V
L
N
G
T
K
M
W
I
S
N
G
G
E
A
E
W
V
V
V
F
A
T
V
N
---------
P
---------
E
LRHK
G
-------
V
V
A
L
V
V
E
R
G
T
P
G
F
K
A
I
K
I
H
G
K
M
G
Q
R
A
S
G
T
Y
E
L
V
F
E
D
V
K
V
P
V
E
N
R
L
G
E
E
G
E
G
F
K
I
A
M
Q
T
L
N
K
T
R
I
P
V
A
A
G
S
V
G
V
A
R
R
A
L
D
E
A
R
K
Y
A
K
E
R
E
A
F
G
E
P
I
A
N
F
Q
A
I
Q
F
K
L
V
D
M
------------------
L
I
G
I
E
T
A
R
M
Y
T
Y
Y
A
A
W
L
A
D
------
Q
G
L
P
H
A
H
A
S
A
I
A
K
A
Y
A
S
E
I
A
F
E
A
A
N
Q
A
I
Q
I
H
G
G
Y
G
Y
V
R
E
F
P
V
E
K
L
L
R
D
V
K
L
N
Q
I
Y
E
G
T
N
E
I
Q
R
L
I
I
A
----------
R
H
I
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
41.13
35%
0
- C2 -
4L1F
5
?
B:
[4-379]
----------------------------------
N
L
T
E
D
Q
----
Q
M
----
I
K
D
M
A
A
E
F
A
E
K
F
L
A
P
T
V
E
E
R
D
K
A
H
I
W
D
R
--
K
L
----
I
D
K
M
G
E
A
G
F
C
G
I
C
F
P
E
E
Y
G
G
M
G
L
D
V
---
L
S
Y
I
L
A
V
E
E
L
S
K
-
V
--
D
-
D
-----
G
T
G
I
T
--
L
S
A
N
V
S
L
C
A
T
P
I
Y
M
F
G
T
E
E
Q
K
Q
K
Y
L
A
P
I
A
E
G
T
H
V
G
A
F
G
L
T
E
P
S
A
G
T
D
A
S
A
Q
Q
T
T
A
V
L
K
--
G
D
K
Y
I
L
N
G
S
K
I
F
I
T
N
G
K
E
A
D
T
Y
V
V
F
A
M
T
D
---------
K
---------
S
----
Q
GVHG---
I
S
A
F
I
L
E
K
G
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
C
E
V
P
K
E
N
L
L
G
K
E
G
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
R
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
A
D
M
-----
A
T
K
I
E
A
A
R
Y
L
V
Y
H
A
A
M
L
----------------
K
N
E
G
K
P
Y
S
E
A
A
---
A
M
A
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
----------
R
A
L
L
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
HHSearch
41.00
30%
-7
- C2 -
3NF4
1
?
A:
[15-386]
----------------------------------
L
P
S
Q
E
A
----
A
E
----
L
I
E
L
T
R
E
I
A
D
K
V
L
D
P
I
V
D
R
H
E
K
-
D
E
-
T
Y
P
E
G
V
----
F
E
Q
L
G
A
A
G
L
L
S
L
P
Q
P
E
E
W
G
G
G
G
Q
P
Y
---
E
V
Y
L
Q
V
L
E
E
I
A
A
R
W
--
A
-
S
-----
V
A
-
V
A
--
V
S
V
H
S
-
L
S
S
H
P
L
L
V
F
G
T
E
E
Q
K
K
R
W
L
P
G
M
L
S
G
E
Q
I
G
A
Y
S
L
S
E
P
Q
A
G
S
D
A
A
A
L
R
C
A
A
T
P
T
--
D
G
G
Y
V
I
N
G
S
K
S
W
I
T
H
G
G
K
A
D
F
Y
T
L
F
A
R
T
G
----------S--------
R
----
G
-------
V
S
C
F
L
V
P
A
D
Q
P
G
L
S
F
G
K
P
E
E
K
M
G
L
H
A
V
P
T
T
S
A
F
Y
D
N
A
R
I
D
A
D
R
R
I
G
E
E
G
Q
G
L
Q
I
A
F
S
A
L
D
S
G
R
L
G
I
A
A
V
A
T
G
L
A
Q
A
A
L
D
E
A
V
A
Y
A
N
E
------
K
I
I
D
H
-
G
L
G
F
L
L
A
D
M
-----
A
A
A
V
A
T
A
R
A
T
Y
L
D
A
A
R
R
R
D
Q
G
-------------------
R
P
Y
S
Q
Q
A
S
I
A
K
L
T
A
T
D
A
A
M
K
V
T
T
D
A
V
Q
V
F
G
G
V
G
Y
T
R
D
Y
R
V
E
R
Y
M
R
E
A
K
I
M
Q
I
F
E
G
T
N
Q
I
Q
R
L
V
I
A
----------
R
G
L
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
40.90
35%
2
- C2 -
4L1F
7
?
A:
[4-379]
----------------------------------
N
L
T
E
D
Q
----
Q
M
----
I
K
D
M
A
A
E
F
A
E
K
F
L
A
P
T
V
E
E
R
D
K
A
H
I
W
D
R
--
K
L
----
I
D
K
M
G
E
A
G
F
C
G
I
C
F
P
E
E
Y
G
G
M
G
L
D
V
---
L
S
Y
I
L
A
V
E
E
L
S
K
-
V
--
D
-
D
-----
G
T
G
I
T
--
L
S
A
N
V
S
L
C
A
T
P
I
Y
M
F
G
T
E
E
Q
K
Q
K
Y
L
A
P
I
A
E
G
T
H
V
G
A
F
G
L
T
E
P
S
A
G
T
D
A
S
A
Q
Q
T
T
A
V
L
K
--
G
D
K
Y
I
L
N
G
S
K
I
F
I
T
N
G
K
E
A
D
T
Y
V
V
F
A
M
T
D
---------
K
---------
S
----
Q
GVHG---
I
S
A
F
I
L
E
K
G
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
C
E
V
P
K
E
N
L
L
G
K
E
G
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
R
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
A
D
M
-----
A
T
K
I
E
A
A
R
Y
L
V
Y
H
A
A
M
L
----------------
K
N
E
G
K
P
Y
S
E
A
A
---
A
M
A
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
----------
R
A
L
L
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
40.20
32%
15
- C2 -
1BUC
3
ACDS_MEGEL
A:
[4-383]
----------------------------------
N
L
T
D
I
Q
----
Q
D
----
F
L
K
L
A
H
D
F
G
E
K
K
L
A
P
T
V
T
E
-
R
D
-
H
K
G
I
Y
D
K
E
L
----
I
D
E
L
L
S
L
G
I
T
G
A
Y
F
E
E
K
Y
G
G
S
G
D
D
G
GD
V
L
S
Y
I
L
A
V
E
E
L
A
K
Y
D
--
A
-
G
-----
V
A
-
I
T
--
L
S
A
T
V
S
L
C
A
N
P
I
W
Q
F
G
T
E
A
Q
K
E
K
F
L
V
P
L
V
E
G
T
K
L
G
A
F
G
L
T
E
P
N
A
G
T
D
A
S
G
Q
Q
T
I
A
T
K
N
D
D
G
T
-
Y
T
L
N
G
S
K
I
F
I
T
N
G
G
A
A
D
I
Y
I
V
F
A
M
T
D
---------
K
---------
S
----
K
GNHG---
I
T
A
F
I
L
E
D
G
T
P
G
F
T
Y
G
K
K
E
D
K
M
G
I
H
T
S
Q
T
M
E
L
V
F
Q
D
V
K
V
P
A
E
N
M
L
G
E
E
G
K
G
F
K
I
A
M
M
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
A
D
A
V
E
Y
S
K
Q
R
V
Q
F
G
K
P
L
C
K
F
Q
S
I
S
F
K
L
A
D
M
-----
K
M
Q
I
E
A
A
R
N
L
V
Y
K
------------
A
A
C
K
K
Q
E
G
K
-------
P
F
T
V
D
A
A
I
A
K
R
V
A
S
D
V
A
M
R
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
E
V
Q
L
M
V
T
G
----------
G
A
L
L
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
39.53
35%
13
- C2 -
1JQI
4
ACADS_RAT
A:
[4-384]
------------------------
V
Y
Q
-----
S
V
E
L
P
E
T
H
----
Q
M
----
L
R
Q
T
C
R
D
F
A
E
K
E
L
V
P
I
A
A
Q
L
D
K
E
H
L
F
P
T
S
Q
------
V
K
K
M
G
E
L
G
L
L
A
M
D
V
P
E
E
L
S
G
A
G
L
D
Y
---
L
A
Y
S
I
A
L
E
E
I
S
R
-
G
--
C
-
A
S
T
G
V
I
M
S
-
V
N
--
N
S
L
Y
L
G
----
P
I
L
K
F
G
S
S
Q
Q
K
Q
Q
W
I
T
P
F
T
N
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
--
R
E
E
G
D
S
W
V
L
N
G
T
K
A
W
I
T
N
S
W
E
A
S
A
T
V
V
F
A
S
T
D
---------
R
---------
S
----
R
QNKG---
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
A
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
E
N
L
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
A
S
L
D
C
A
V
K
Y
A
E
N
R
H
A
F
G
A
P
L
T
K
L
Q
N
I
Q
F
K
L
A
D
M
-----
A
L
A
L
E
S
A
R
L
L
T
W
R
-
A
A
M
L
K
D
N
K
K
P
F
T
K
E
S
------------------
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
Y
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
----------
G
H
L
L
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
38.83
35%
8
- C2 -
1JQI
4
ACADS_RAT
B:
[4-384]
------------------------
V
Y
Q
-----
S
V
E
L
P
E
T
H
----
Q
M
----
L
R
Q
T
C
R
D
F
A
E
K
E
L
V
P
I
A
A
Q
L
D
K
E
H
L
F
P
T
S
Q
------
V
K
K
M
G
E
L
G
L
L
A
M
D
V
P
E
E
L
S
G
A
G
L
D
Y
---
L
A
Y
S
I
A
L
E
E
I
S
R
-
G
--
C
-
A
STGVI
M
S
-
V
N
--
N
S
L
Y
L
G
----
P
I
L
K
F
G
S
S
Q
Q
K
Q
Q
W
I
T
P
F
T
N
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
--
R
E
E
G
D
S
W
V
L
N
G
T
K
A
W
I
T
N
S
W
E
A
S
A
T
V
V
F
A
S
T
D
---------
R
---------
S
----
R
QNKG---
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
A
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
E
N
L
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
A
S
L
D
C
A
V
K
Y
A
E
N
R
H
A
F
G
A
P
L
T
K
L
Q
N
I
Q
F
K
L
A
D
M
-----
A
L
A
L
E
S
A
R
L
L
T
W
R
-
A
A
M
L
K
D
N
K
K
P
F
T
K
E
S
------------------
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
Y
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
----------
G
H
L
L
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
37.20
33%
2
- C2 -
4N5F
10
?
A:
[11-381]
---------------------------------
E
L
Y
T
E
D
Q
----
R
M
----
I
R
D
A
A
R
A
F
A
T
E
M
L
A
P
N
A
------
A
Q
W
D
H
D
A
H
L
P
D
A
I
V
A
Q
L
G
E
L
G
L
L
G
M
I
V
P
Q
E
L
G
G
S
Y
T
D
Y
---
V
A
Y
A
L
A
M
E
E
V
A
--
A
--
G
-
D
-----
A
A
-
C
A
T
M
M
S
V
H
N
S
V
G
C
G
P
I
L
G
F
G
T
P
A
Q
K
D
R
W
L
A
D
M
A
A
G
R
V
I
G
A
F
C
L
T
E
P
H
A
G
S
E
A
N
N
L
R
T
R
A
E
L
R
D
G
--
Q
W
V
L
N
G
A
K
Q
F
V
T
N
G
Q
R
A
G
V
A
I
V
F
A
M
T
D
---------
P
---------
E
----
A
GKRG---
I
S
A
F
L
V
P
T
D
T
P
G
F
I
V
G
K
P
E
K
K
M
G
I
R
A
S
D
T
C
P
I
T
F
E
N
C
A
I
P
E
D
N
L
L
G
N
R
G
E
G
L
K
I
A
L
S
N
L
E
G
G
R
I
G
I
A
A
Q
A
L
G
I
A
R
A
A
F
D
K
A
R
R
Y
A
G
E
R
V
Q
F
G
K
P
I
A
E
H
Q
A
I
Q
Q
K
L
A
D
M
A
V
Q
I
N
A
A
R
L
L
V
H
H
A
A
K
L
R
T
A
G
L
------------------------
P
C
L
S
E
A
S
Q
A
K
L
F
A
S
E
M
A
E
R
V
C
S
D
A
I
Q
I
H
G
G
Y
G
Y
L
V
D
Y
E
V
E
R
H
Y
R
D
A
R
I
T
Q
I
Y
E
G
T
S
E
V
Q
R
M
V
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
35.49
33%
-5
- C2 -
4N5F
10
?
B:
[11-381]
---------------------------------
E
L
Y
T
E
D
Q
----
R
M
----
I
R
D
A
A
R
A
F
A
T
E
M
L
A
P
N
A
------
A
Q
W
D
H
D
A
H
L
P
D
A
I
V
A
Q
L
G
E
L
G
L
L
G
M
I
V
P
Q
E
L
G
G
S
Y
T
D
Y
---
V
A
Y
A
L
A
M
E
E
V
A
--
A
--
G
-
D
-----
A
A
-
C
A
T
M
M
S
V
H
N
S
V
G
C
G
P
I
L
G
F
G
T
P
A
Q
K
D
R
W
L
A
D
M
A
A
G
R
V
I
G
A
F
C
L
T
E
P
H
-------
L
R
T
R
A
E
L
R
D
----
W
V
L
N
G
A
K
Q
F
V
T
N
G
Q
R
A
G
V
A
I
V
F
A
M
T
D
---------
P
---------
E
----
A
GKRG---
I
S
A
F
L
V
P
T
D
T
P
G
F
I
V
G
K
P
E
K
K
M
G
I
R
A
S
D
T
C
P
I
T
F
E
N
C
A
I
P
E
D
N
L
L
G
N
R
G
E
G
L
K
I
A
L
S
N
L
E
G
G
R
I
G
I
A
A
Q
A
L
G
I
A
R
A
A
F
D
K
A
R
R
Y
A
G
E
R
V
Q
F
G
K
P
I
A
E
H
Q
A
I
Q
Q
K
L
A
D
M
A
V
Q
I
N
A
A
R
L
L
V
H
H
A
A
K
L
R
T
A
G
L
------------------------
P
C
L
S
E
A
S
Q
A
K
L
F
A
S
E
M
A
E
R
V
C
S
D
A
I
Q
I
H
G
G
Y
G
Y
L
V
D
Y
E
V
E
R
H
Y
R
D
A
R
I
T
Q
I
Y
E
G
T
S
E
V
Q
R
M
V
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------