@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu32830: (2016-07-24 )
MKEAVIVSGARTPVGKAKKGSLATVRPDDLGAICVKETLKRAGGYEGNIDDLIIGCATPEAEQGLNMARNIGALAGLPYTVPAITVNRYCSSGLQSIAYAAEKIMLGAYDTAIAGGAESMSQVPMMGHVTRPNLALAEKAPEYYMSMGHTAEQVAKKYGVSREDQDAFAVRSHQNAAKALAEGKFKDEIVPVEVTVTEIGEDHKPMEKQFVFSQDEGVRPQTTADILSTLRPAFSVDGTVTAGNSSQTSDGAAAVMLMDREKADALGLAPLVKFRSFAVGGVPPEVMGIGPVEAIPRALKLAGLQLQDIGLFELNEAFASQAIQVIRELGIDEEKVNVNGGAIALGHPLGCTGTKLTLSLIHEMKRRNEQFGVVTMCIGGGMGAAGVFELC
Atome Classification :
(30 SA)
.........10.......-.-20........30........40-.-.----...-.-..50........60........70........80........90........100.......110.......120......-.-130------.---..--------------.----.--..--------.140--------.----------.-------------......---150.......160.......170.......180.......190.......200....-...210.......220.......230...-.--..-.240.......250.......260.......270.......280.......290.......300.......310.......320.......330---.---......340.......350.......360......--.--370........380.......390
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
E
A
V
I
VSGARTPVGKAK-K-G
S
L
A
TVRPD
D
L
G
A
I
C
V
K
E
T
L
K
R-A-G----GYE-G-NID
D
L
I
I
GCAT
P
E
A
E
Q
G
L
N
M
A
R
N
I
G
A
LAGLPYTVP
A
I
T
V
N
R
Y
C
S
S
G
L
Q
S
I
A
Y
A
A
E
K
I
M
LGAY
D
T
AIAGG
A
E
S
M
S
QVPMMGH-V-TR-------P---N
L
--------------
A
----
L
--
A
E
--------KA
P
---------
E
----------
Y
-------------
Y
M
SMG
H
---
T
A
E
Q
V
A
K
KYGVSREDQ
D
A
F
A
V
RSH
Q
N
A
A
K
A
L
AEGKFKD
E
I
V
P
V
E
V
T
V
TEIGEDHKP
M
-
E
K
Q
F
V
FSQDEGVRPQ
T
T
A
D
I
L
S
TLRPAFS-V--D
G
-
T
V
TAGNSSQTSDG
A
A
A
V
M
L
M
DREKADALG
L
A
P
L
V
K
F
R
S
FAVGGV
P
P
E
VMGI
G
P
V
E
A
I
P
R
A
L
K
L
AG
L
Q
L
Q
D
I
G
L
F
E
L
N
E
A
F
A
S
Q
A
I
Q
V
I
R
E
LGID---E---
E
K
V
NVNG
G
A
I
A
LGHPLGCTG
T
K
L
T
L
S
L
I
H
E
M
K
R
RN--E--Q-F
G
V
V
T
M
C
IGGGMGAAGVFELC
3
PsiBlast_PDB
95.87
48%
-75
- C8 -
2C7Y
-
THIK2_ARATH
A:
[51-437]
--
D
V
V
I
V
A
A
H
R
T
P
L
C
K
S
K
-
R
-
G
N
F
K
D
T
Y
P
D
D
L
L
A
P
V
L
R
A
L
I
E
K
-
T
-
N
----
L
N
P
-
S
-
E
V
G
D
I
V
V
G
T
V
L
A
P
G
S
Q
R
A
S
E
C
R
M
A
A
F
Y
A
G
F
P
E
T
V
A
V
R
T
V
N
R
Q
C
S
S
G
L
Q
A
V
A
D
V
A
A
A
I
K
A
G
F
Y
D
I
G
I
G
A
G
L
E
S
M
T
T
N
P
-----------------------------------------
K
--
F
A
--------
Q
A
Q
---------
N
----------
C
-------------
L
L
P
M
G
V
---
T
S
E
N
V
A
Q
R
F
G
V
S
R
Q
E
Q
D
Q
A
A
V
D
S
H
R
K
A
A
A
A
T
A
A
G
K
F
K
D
E
I
I
P
V
K
---
T
K
L
V
D
P
K
T
G
D
-
E
K
P
I
T
V
S
V
D
D
G
I
R
P
T
T
T
L
A
S
L
G
K
L
K
P
V
F
K
-
K
--
D
G
-
T
T
T
A
G
N
S
S
Q
V
S
D
G
A
G
A
V
L
L
M
K
R
S
V
A
M
Q
K
G
L
P
V
L
G
V
F
R
T
F
A
A
V
G
V
D
P
A
I
M
G
I
G
P
A
V
A
I
P
A
A
V
K
A
A
G
L
E
L
D
D
I
D
L
F
E
I
N
E
A
F
A
S
Q
F
V
Y
C
R
N
K
L
G
L
D
---
P
---
E
K
I
N
V
N
G
G
A
M
A
I
G
H
P
L
G
A
T
G
A
R
C
V
A
T
L
L
H
E
M
K
R
R
G
--
K
DC
R
-
F
G
V
V
S
M
C
I
G
T
G
M
G
A
A
A
V
F
E
--
4
PsiBlast_PDB
95.19
48%
-76
- C8 -
2C7Z
-
THIK2_ARATH
A:
[51-437]
--
D
V
V
I
V
A
A
H
R
T
P
L
C
K
S
K
-
R
-
G
N
F
K
D
T
Y
P
D
D
L
L
A
P
V
L
R
A
L
I
E
K
-
T
-
N
----
L
N
P
-
S
-
E
V
G
D
I
V
V
G
T
V
L
A
P
G
S
Q
R
A
S
E
C
R
M
A
A
F
Y
A
G
F
P
E
T
V
A
V
R
T
V
N
R
Q
C
S
S
G
L
Q
A
V
A
D
V
A
A
A
I
K
A
G
F
Y
D
I
G
I
G
A
G
L
E
S
M
T
T
N
P
M
A
W
E
--------------------------------
K
----
K
--
F
A
--------
Q
A
Q
---------
N
----------
C
-------------
L
L
P
M
G
V
---
T
S
E
N
V
A
Q
R
F
G
V
S
R
Q
E
Q
D
Q
A
A
V
D
S
H
R
K
A
A
A
A
T
A
A
G
K
F
K
D
E
I
I
P
V
K
---
T
K
L
V
D
P
K
T
G
D
-
E
K
P
I
T
V
S
V
D
D
G
I
R
P
T
T
T
L
A
S
L
G
K
L
K
P
V
F
K
-
K
--
D
G
-
T
T
T
A
G
N
S
S
Q
V
S
D
G
A
G
A
V
L
L
M
K
R
S
V
A
M
Q
K
G
L
P
V
L
G
V
F
R
T
F
A
A
V
G
V
D
P
A
I
M
G
I
G
P
A
V
A
I
P
A
A
V
K
A
A
G
L
E
L
D
D
I
D
L
F
E
I
N
E
A
F
A
S
Q
F
V
Y
C
R
N
K
L
G
L
D
---
P
---
E
K
I
N
V
N
G
G
A
M
A
I
G
H
P
L
G
A
T
G
A
R
C
V
A
T
L
L
H
E
M
K
R
R
G
--
K
DC
R
-
F
G
V
V
S
M
C
I
G
T
G
M
G
A
A
A
V
F
E
--
6
PsiBlast_PDB
92.82
47%
-75
- C8 -
2IIK
-
THIK_HUMAN
A:
[37-421]
--
D
V
V
V
V
H
G
R
R
T
A
I
C
R
A
G
-
R
-
G
G
F
K
D
T
T
P
D
E
L
L
S
A
V
M
T
A
V
L
K
D
-
V
-
N
----
L
R
P
-
E
-
Q
L
G
D
I
C
V
G
N
V
L
-
Q
P
G
A
G
A
I
M
A
R
I
A
Q
F
L
S
D
I
P
E
T
V
P
L
S
T
V
N
R
Q
C
S
S
G
L
Q
A
V
A
S
I
A
G
G
I
R
N
G
S
Y
D
I
G
M
A
C
G
V
E
S
M
S
L
A
D
--
G
N
-
I
-
T
S
-----------
R
L
--------------
M
----
E
--
K
E
--------
K
A
R
---------
D
----------
C
-------------
L
I
P
M
G
I
---
T
S
E
N
V
A
E
R
F
G
I
S
R
E
K
Q
D
T
F
A
L
A
S
Q
Q
K
A
A
R
A
Q
S
K
G
C
F
Q
A
E
I
V
P
V
T
T
T
V
----
H
D
D
K
G
T
-
K
R
S
I
T
V
T
Q
D
E
G
I
R
P
S
T
T
M
E
G
L
A
K
L
K
P
A
F
K
-
K
--
D
G
-
S
T
T
A
G
N
S
S
Q
V
S
D
G
A
A
A
I
L
L
A
R
R
S
K
A
E
E
L
G
L
P
I
L
G
V
L
R
S
Y
A
V
V
G
V
P
P
D
I
M
G
I
G
P
A
Y
A
I
P
V
A
L
Q
K
A
G
L
T
V
S
D
V
D
I
F
E
I
N
E
A
F
A
S
Q
A
A
Y
C
V
E
K
L
R
L
P
---
P
---
E
K
V
N
P
L
G
G
A
V
A
L
G
H
P
L
G
C
T
G
A
R
Q
V
I
T
L
L
N
E
L
K
R
R
G
--
K
--
R
A
Y
G
V
V
S
M
C
I
G
T
G
M
G
A
A
A
V
F
E
--
21
PsiBlast_CBE
88.96
48%
-31
- C8 -
2WU9
3
THIK2_ARATH
B:
[31-417]
--
D
V
V
I
V
A
A
H
R
T
P
L
C
K
S
K
-
R
-
G
N
F
K
D
T
Y
P
D
D
L
L
A
P
V
L
R
A
L
I
E
K
-
T
-
N
----
L
N
P
-
S
-
E
V
G
D
I
V
V
G
T
V
L
A
P
G
S
Q
R
A
S
E
C
R
M
A
A
F
Y
A
G
F
P
E
T
V
A
V
R
T
V
N
R
Q
C
S
S
G
L
Q
A
V
A
D
V
A
A
A
I
K
A
G
F
Y
D
I
G
I
G
A
G
L
E
S
M
T
T
N
P
M
A
W
E
G
S
-
V
N
-------
P
---
A
V
--------------
K
----
K
--
F
A
--------
Q
A
Q
---------
N
----------
C
-------------
L
L
P
M
G
V
---
T
S
E
N
V
A
Q
R
F
G
V
S
R
Q
E
Q
D
Q
A
A
V
D
S
H
R
K
A
A
A
A
T
A
A
G
K
F
K
D
E
I
I
P
V
K
---
T
K
L
V
D
P
K
T
G
D
-
E
K
P
I
T
V
S
V
D
D
G
I
R
P
T
T
T
L
A
S
L
G
K
L
K
P
V
F
K
-
K
--
D
G
-
T
T
T
A
G
N
S
S
Q
V
S
D
G
A
G
A
V
L
L
M
K
R
S
V
A
M
Q
K
G
L
P
V
L
G
V
F
R
T
F
A
A
V
G
V
D
P
A
I
M
G
I
G
P
A
V
A
I
P
A
A
V
K
A
A
G
L
E
L
D
D
I
D
L
F
E
I
N
E
A
F
A
S
Q
F
V
Y
C
R
N
K
L
G
L
D
---
P
---
E
K
I
N
V
N
G
G
A
M
A
I
G
H
P
L
G
A
T
G
A
R
C
V
A
T
L
L
H
E
M
K
R
R
G
--
K
DC
R
-
F
G
V
V
S
M
C
I
G
T
G
M
G
A
A
A
V
F
E
--
2
PsiBlast_PDB
88.75
48%
-30
- C8 -
2WU9
6
THIK2_ARATH
A:
[31-417]
--
D
V
V
I
V
A
A
H
R
T
P
L
C
K
S
K
-
R
-
G
N
F
K
D
T
Y
P
D
D
L
L
A
P
V
L
R
A
L
I
E
K
-
T
-
N
----
L
N
P
-
S
-
E
V
G
D
I
V
V
G
T
V
L
A
P
G
S
Q
R
A
S
E
C
R
M
A
A
F
Y
A
G
F
P
E
T
V
A
V
R
T
V
N
R
Q
C
S
S
G
L
Q
A
V
A
D
V
A
A
A
I
K
A
G
F
Y
D
I
G
I
G
A
G
L
E
S
M
T
T
N
P
M
A
W
E
G
S
-
V
N
-------
P
---
A
V
--------------
K
----
K
--
F
A
--------
Q
A
Q
---------
N
----------
C
-------------
L
L
P
M
G
V
---
T
S
E
N
V
A
Q
R
F
G
V
S
R
Q
E
Q
D
Q
A
A
V
D
S
H
R
K
A
A
A
A
T
A
A
G
K
F
K
D
E
I
I
P
V
K
---
T
K
L
V
D
P
K
T
G
D
-
E
K
P
I
T
V
S
V
D
D
G
I
R
P
T
T
T
L
A
S
L
G
K
L
K
P
V
F
K
-
K
--
D
G
-
T
T
T
A
G
N
S
S
Q
V
S
D
G
A
G
A
V
L
L
M
K
R
S
V
A
M
Q
K
G
L
P
V
L
G
V
F
R
T
F
A
A
V
G
V
D
P
A
I
M
G
I
G
P
A
V
A
I
P
A
A
V
K
A
A
G
L
E
L
D
D
I
D
L
F
E
I
N
E
A
F
A
S
Q
F
V
Y
C
R
N
K
L
G
L
D
---
P
---
E
K
I
N
V
N
G
G
A
M
A
I
G
H
P
L
G
A
T
G
A
R
C
V
A
T
L
L
H
E
M
K
R
R
G
--
K
DC
R
-
F
G
V
V
S
M
C
I
G
T
G
M
G
A
A
A
V
F
E
--
101
HHSearch
88.33
49%
-33
- C8 -
2WU9
7
THIK2_ARATH
A:
[29-418]
G
D
D
V
V
I
V
A
A
H
R
T
P
L
C
K
S
K
-
R
-
G
N
F
K
D
T
Y
P
D
D
L
L
A
P
V
L
R
A
L
I
E
K
-
T
-
N
----
L
N
P
-
S
-
E
V
G
D
I
V
V
G
T
V
L
A
P
G
S
Q
R
A
S
E
C
R
M
A
A
F
Y
A
G
F
P
E
T
V
A
V
R
T
V
N
R
Q
C
S
S
G
L
Q
A
V
A
D
V
A
A
A
I
K
A
G
F
Y
D
I
G
I
G
A
G
L
E
S
M
T
T
N
P
M
A
W
E
-
G
-
S
V
N------
P
---
A
V
--------------
K
----
K
--
F
A
--------
Q
A
Q
---------
N
----------
C
-------------
L
L
P
M
G
V
---
T
S
E
N
V
A
Q
R
F
G
V
S
R
Q
E
Q
D
Q
A
A
V
D
S
H
R
K
A
A
A
A
T
A
A
G
K
F
K
D
E
I
I
P
V
K
T
K
L
V
D
P
K
T
G
---
D
-
E
K
P
I
T
V
S
V
D
D
G
I
R
P
T
T
T
L
A
S
L
G
K
L
K
P
V
F
K
-
K
--
D
G
-
T
T
T
A
G
N
S
S
Q
V
S
D
G
A
G
A
V
L
L
M
K
R
S
V
A
M
Q
K
G
L
P
V
L
G
V
F
R
T
F
A
A
V
G
V
D
P
A
I
M
G
I
G
P
A
V
A
I
P
A
A
V
K
A
A
G
L
E
L
D
D
I
D
L
F
E
I
N
E
A
F
A
S
Q
F
V
Y
C
R
N
K
L
G
L
D
---
P
---
E
K
I
N
V
N
G
G
A
M
A
I
G
H
P
L
G
A
T
G
A
R
C
V
A
T
L
L
H
E
M
K
R
R
G
KD
C
--
R
-
F
G
V
V
S
M
C
I
G
T
G
M
G
A
A
A
V
F
E
R
-
1
PsiBlast_PDB
86.75
47%
-31
- C- -
2WUA
-
?
A:
[49-435]
--
D
V
V
I
V
A
A
Y
R
S
P
L
C
K
A
K
-
R
-
G
G
L
K
D
T
Y
P
D
D
I
L
A
P
V
L
K
A
L
I
E
K
-
T
-
N
----
I
N
P
-
A
-
E
V
G
D
I
V
V
G
S
V
L
G
A
G
S
Q
R
A
S
E
C
R
M
A
A
F
Y
A
G
F
P
E
T
V
P
V
R
T
V
N
R
Q
C
S
S
G
L
Q
A
V
A
D
V
A
A
A
I
K
A
G
F
Y
D
I
G
I
G
A
G
L
E
S
M
T
A
N
P
M
A
W
E
G
S
-
V
N
-------
P
---
K
V
--------------
K
----
T
--
M
A
--------
Q
A
Q
---------
D
----------
C
-------------
L
L
P
M
G
I
---
T
S
E
N
V
A
Q
K
F
S
I
T
R
Q
E
Q
D
Q
A
A
V
G
S
H
R
K
T
A
A
A
T
A
A
G
R
F
K
D
E
I
I
P
I
K
---
T
K
I
V
D
P
K
T
G
D
-
E
K
P
V
T
I
S
V
D
D
G
I
R
P
G
T
S
L
A
D
L
A
K
L
K
P
V
F
R
-
K
--
D
G
-
S
T
T
A
G
T
S
S
Q
V
S
D
G
A
G
A
V
L
L
M
K
R
S
I
A
L
Q
K
G
L
P
I
L
G
V
F
R
T
F
A
A
V
G
V
P
P
S
I
M
G
I
G
P
A
V
A
I
P
A
A
V
K
A
A
G
L
Q
I
D
D
I
D
L
F
E
I
N
E
A
F
A
S
Q
F
V
Y
C
Q
K
K
L
E
I
D
---
P
---
Q
K
I
N
V
N
G
G
A
M
A
I
G
H
P
L
G
A
T
G
A
R
C
V
A
T
L
L
H
E
M
K
R
R
G
--
R
DC
R
-
F
G
V
V
S
M
C
I
G
T
G
M
G
A
A
A
V
F
E
--
112
HHSearch
83.37
46%
-19
- C8 -
1WDK
2
FADA_PSEFR
C:
[5-390]
-
R
D
V
V
I
V
D
F
G
R
T
P
M
G
R
S
K
-
G
-
G
M
H
R
N
T
R
A
E
D
M
S
A
H
L
I
S
K
V
L
E
R
N
S
-
K
----
V
D
P
-
G
-
E
V
E
D
V
I
W
G
C
V
N
Q
T
L
E
Q
G
W
N
I
A
R
M
A
S
L
M
T
Q
I
P
H
T
S
A
A
Q
T
V
S
R
L
C
G
S
S
M
S
A
L
H
T
A
A
Q
A
I
M
T
G
N
G
D
V
F
V
V
G
G
V
E
H
M
G
H
V
S
M
M
H
G
-
V
-
D
--------
P
---
N
P
--------------
H
----
M
--
S
L
--------
Y
A
A
---------
K
----------
A
-------------
S
G
M
M
G
L
---
T
A
E
M
L
G
K
M
H
G
I
S
R
E
Q
Q
D
A
F
A
V
R
S
H
Q
L
A
H
K
A
T
V
E
G
K
F
K
D
E
I
I
P
M
Q
G
Y
D
--------
E
N
-
G
F
L
K
I
F
D
Y
D
E
T
I
R
P
D
T
T
L
E
S
L
A
A
L
K
P
A
F
N
-
P
K-
G
G
-
T
V
T
A
G
T
S
S
Q
I
T
D
G
A
S
C
M
I
V
M
S
A
Q
R
A
K
D
L
G
L
E
P
L
A
V
I
R
S
M
A
V
A
G
V
D
P
A
I
M
G
Y
G
P
V
P
A
T
Q
K
A
L
K
R
A
G
L
N
M
A
D
I
D
F
I
E
L
N
E
A
F
A
A
Q
A
L
P
V
L
K
D
L
K
V
L
---
D
KMN
E
K
V
N
L
H
G
G
A
I
A
L
G
H
P
F
G
C
S
G
A
R
I
S
G
T
L
L
N
V
M
K
Q
N
G
--
G
--
T
-
F
G
L
S
T
M
C
I
G
L
G
Q
G
I
A
T
V
F
E
R
V
115
HHSearch
83.31
48%
-25
* C8 *
4WYS
-
ATOB_ECOLI
A:
[1-392]
M
K
N
C
V
I
V
S
A
V
R
T
A
I
G
S
-
F
-
N
-
G
S
L
A
S
T
S
A
I
D
L
G
A
T
V
I
K
A
A
I
E
R
-
A
-
K
----
I
D
S
-
Q
-
H
V
D
E
V
I
M
G
N
V
L
Q
A
G
L
-
G
Q
N
P
A
R
Q
A
L
L
K
S
G
L
A
E
T
V
C
G
F
T
V
N
K
V
C
G
S
G
L
K
S
V
A
L
A
A
Q
A
I
Q
A
G
Q
A
Q
S
I
V
A
G
G
M
E
N
M
S
L
A
P
Y
L
L
D
-
A
K
A
R
-------
S
GYR
L
G
--------------
D
----
G
--
Q
V
--------
Y
D
V
I
L
R
D
GLMCA
T
----------
H
-------------
G
Y
H
M
G
I
---
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
M
Q
D
E
L
A
L
H
S
Q
R
K
A
A
A
A
I
E
S
G
A
F
T
A
E
I
V
P
V
N
V
V
T
---------
R
-
K
K
T
F
V
F
S
Q
D
E
F
P
K
A
N
S
T
A
E
A
L
G
A
L
R
P
A
F
D
-
K
--
A
G
-
T
V
T
A
G
N
A
S
G
I
N
D
G
A
A
A
L
V
I
M
E
E
S
A
A
L
A
A
G
L
T
P
L
A
R
I
K
S
Y
A
S
G
G
V
P
P
A
L
M
G
M
G
P
V
P
A
T
Q
K
A
L
Q
L
A
G
L
Q
L
A
D
I
D
L
I
E
A
N
E
A
F
A
A
Q
F
L
A
V
G
K
N
L
G
F
D
---
S
---
E
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
L
H
A
M
Q
A
R
D
--
K
--
T
-
L
G
L
A
T
L
C
I
G
G
G
Q
G
I
A
M
V
I
E
R
-
12
PsiBlast_PDB
83.22
45%
-14
- C8 -
3GOA
2
FADA_SALTY
A:
[2-385]
-
E
Q
V
V
I
V
D
A
I
R
T
P
M
G
R
S
K
-
G
-
G
A
F
R
N
V
R
A
E
D
L
S
A
H
L
M
R
S
L
L
A
R
-
N
-
P
----
S
L
T
-
A
A
T
L
D
D
I
Y
W
G
C
V
Q
Q
T
L
E
Q
G
F
N
I
A
R
N
A
A
L
L
A
E
I
P
H
S
V
P
A
V
T
V
N
R
L
C
G
S
S
M
Q
A
L
H
D
A
A
R
M
I
M
T
G
D
A
Q
V
C
L
V
G
G
V
E
H
M
G
H
V
P
M
-
S
H
-
G
-
V
D
-------
F
---
H
P
--------------
G
----
L
--
S
-----------------------------------------------
G
M
M
G
L
---
T
A
E
M
L
S
R
L
H
G
I
S
R
E
M
Q
D
Q
F
A
A
R
S
H
A
R
A
W
A
A
T
Q
S
G
A
F
K
T
E
I
I
P
T
G
------
G
H
D
A
D
G
V
-
L
K
Q
F
N
Y
--
D
E
V
I
R
P
E
T
T
V
E
A
L
S
T
L
R
P
A
F
D
P
V
--
S
G
-
T
V
T
A
G
T
S
S
A
L
S
D
G
A
A
A
M
L
V
M
S
E
S
R
A
R
E
L
G
L
K
P
R
A
R
I
R
S
M
A
V
V
G
C
D
P
S
I
M
G
Y
G
P
V
P
A
S
K
L
A
L
K
K
A
G
L
S
A
S
D
I
D
V
F
E
M
N
E
A
F
A
A
Q
I
L
P
C
I
K
D
L
G
L
M
---
E
QID
E
K
I
N
L
N
G
G
A
I
A
L
G
H
P
L
G
C
S
G
A
R
I
S
T
T
L
I
N
L
M
E
R
K
D
--
A
--
Q
-
F
G
L
A
T
M
C
I
G
L
G
Q
G
I
A
T
V
F
E
--
7
PsiBlast_PDB
83.12
45%
-14
- C8 -
1WDK
2
FADA_PSEFR
C:
[5-388]
-
R
D
V
V
I
V
D
F
G
R
T
P
M
G
R
S
K
-
G
-
G
M
H
R
N
T
R
A
E
D
M
S
A
H
L
I
S
K
V
L
E
R
-
N
-
S
----
K
V
D
P
G
-
E
V
E
D
V
I
W
G
C
V
N
Q
T
L
E
Q
G
W
N
I
A
R
M
A
S
L
M
T
Q
I
P
H
T
S
A
A
Q
T
V
S
R
L
C
G
S
S
M
S
A
L
H
T
A
A
Q
A
I
M
T
G
N
G
D
V
F
V
V
G
G
V
E
H
M
G
H
V
S
M
M
-
H
-
G
-
V
D
-------
P
---
N
P
--------------
H
----
M
--
S
L
--------
Y
A
A
---------
K
----------
A
-------------
S
G
M
M
G
L
---
T
A
E
M
L
G
K
M
H
G
I
S
R
E
Q
Q
D
A
F
A
V
R
S
H
Q
L
A
H
K
A
T
V
E
G
K
F
K
D
E
I
I
P
M
Q
------
G
Y
D
E
N
G
F
-
L
K
--
I
F
D
Y
D
E
T
I
R
P
D
T
T
L
E
S
L
A
A
L
K
P
A
F
N
-
P
--
K
G
G
T
V
T
A
G
T
S
S
Q
I
T
D
G
A
S
C
M
I
V
M
S
A
Q
R
A
K
D
L
G
L
E
P
L
A
V
I
R
S
M
A
V
A
G
V
D
P
A
I
M
G
Y
G
P
V
P
A
T
Q
K
A
L
K
R
A
G
L
N
M
A
D
I
D
F
I
E
L
N
E
A
F
A
A
Q
A
L
P
V
L
K
D
L
K
V
L
---
D
KMN
E
K
V
N
L
H
G
G
A
I
A
L
G
H
P
F
G
C
S
G
A
R
I
S
G
T
L
L
N
V
M
K
Q
N
G
--
G
--
T
-
F
G
L
S
T
M
C
I
G
L
G
Q
G
I
A
T
V
F
E
--
104
HHSearch
82.83
47%
-9
- C8 -
3GOA
2
FADA_SALTY
A:
[1-386]
M
E
Q
V
V
I
V
D
A
I
R
T
P
M
G
R
-
S
-
K
G
G
A
F
R
N
V
R
A
E
D
L
S
A
H
L
M
R
S
L
L
A
R
-
N
P
S
----
L
T
A
-
A
-
T
L
D
D
I
Y
W
G
C
V
Q
Q
T
L
E
Q
G
F
N
I
A
R
N
A
A
L
L
A
E
I
P
H
S
V
P
A
V
T
V
N
R
L
C
G
S
S
M
Q
A
L
H
D
A
A
R
M
I
M
T
G
D
A
Q
V
C
L
V
G
G
V
E
H
M
G
H
V
P
M
S
H
G
----
V
-----------
D
F
--------------
H
----
P
--
G
L
--------
S
-------------------------------------
G
M
M
G
L
---
T
A
E
M
L
S
R
L
H
G
I
S
R
E
M
Q
D
Q
F
A
A
R
S
H
A
R
A
W
A
A
T
Q
S
G
A
F
K
T
E
I
I
P
T
G
G
--------
H
D
A
D
-
G
V
L
K
Q
F
N
Y
D
E
V
I
R
P
E
T
T
V
E
A
L
S
T
L
R
P
A
F
D
-
P
V-
S
G
-
T
V
T
A
G
T
S
S
A
L
S
D
G
A
A
A
M
L
V
M
S
E
S
R
A
R
E
L
G
L
K
P
R
A
R
I
R
S
M
A
V
V
G
C
D
P
S
I
M
G
Y
G
P
V
P
A
S
K
L
A
L
K
K
A
G
L
S
A
S
D
I
D
V
F
E
M
N
E
A
F
A
A
Q
I
L
P
C
I
K
D
L
G
L
M
EQI
D
---
E
K
I
N
L
N
G
G
A
I
A
L
G
H
P
L
G
C
S
G
A
R
I
S
T
T
L
I
N
L
M
E
R
K
D
--
A
--
Q
-
F
G
L
A
T
M
C
I
G
L
G
Q
G
I
A
T
V
F
E
R
-
25
PsiBlast_CBE
82.72
45%
-12
- C8 -
1WDK
2
FADA_PSEFR
D:
[5-388]
-
R
D
V
V
I
V
D
F
G
R
T
P
M
G
R
S
K
-
G
-
G
M
H
R
N
T
R
A
E
D
M
S
A
H
L
I
S
K
V
L
E
R
-
N
-
S
----
K
V
D
P
G
-
E
V
E
D
V
I
W
G
C
V
N
Q
T
L
E
Q
G
W
N
I
A
R
M
A
S
L
M
T
Q
I
P
H
T
S
A
A
Q
T
V
S
R
L
C
G
S
S
M
S
A
L
H
T
A
A
Q
A
I
M
T
G
N
G
D
V
F
V
V
G
G
V
E
H
M
G
H
V
S
M
M
-
H
-
G
-
V
D
-------
P
---
N
P
--------------
H
----
M
--
S
L
--------
Y
A
A
---------
K
----------
A
-------------
S
G
M
M
G
L
---
T
A
E
M
L
G
K
M
H
G
I
S
R
E
Q
Q
D
A
F
A
V
R
S
H
Q
L
A
H
K
A
T
V
E
G
K
F
K
D
E
I
I
P
M
Q
------
G
Y
D
E
N
G
F
-
L
K
--
I
F
D
Y
D
E
T
I
R
P
D
T
T
L
E
S
L
A
A
L
K
P
A
F
N
-
P
--
K
G
G
T
V
T
A
G
T
S
S
Q
I
T
D
G
A
S
C
M
I
V
M
S
A
Q
R
A
K
D
L
G
L
E
P
L
A
V
I
R
S
M
A
V
A
G
V
D
P
A
I
M
G
Y
G
P
V
P
A
T
Q
K
A
L
K
R
A
G
L
N
M
A
D
I
D
F
I
E
L
N
E
A
F
A
A
Q
A
L
P
V
L
K
D
L
K
V
L
---
D
KMN
E
K
V
N
L
H
G
G
A
I
A
L
G
H
P
F
G
C
S
G
A
R
I
S
G
T
L
L
N
V
M
K
Q
N
G
--
G
--
T
-
F
G
L
S
T
M
C
I
G
L
G
Q
G
I
A
T
V
F
E
--
10
PsiBlast_PDB
82.69
45%
-14
- C8 -
2D3T
1
FADA_PSEFR
C:
[5-388]
-
R
D
V
V
I
V
D
F
G
R
T
P
M
G
R
S
K
-
G
-
G
M
H
R
N
T
R
A
E
D
M
S
A
H
L
I
S
K
V
L
E
R
-
N
-
S
----
K
V
D
P
G
-
E
V
E
D
V
I
W
G
C
V
N
Q
T
L
E
Q
G
W
N
I
A
R
M
A
S
L
M
T
Q
I
P
H
T
S
A
A
Q
T
V
S
R
L
C
G
S
S
M
S
A
L
H
T
A
A
Q
A
I
M
T
G
N
G
D
V
F
V
V
G
G
V
E
H
M
G
H
V
S
M
M
-
H
-
G
-
V
D
-------
P
---
N
P
--------------
H
----
M
--
S
L
--------
Y
A
A
---------
K
----------
A
-------------
S
G
M
M
G
L
---
T
A
E
M
L
G
K
M
H
G
I
S
R
E
Q
Q
D
A
F
A
V
R
S
H
Q
L
A
H
K
A
T
V
E
G
K
F
K
D
E
I
I
P
M
Q
------
G
Y
D
E
N
G
F
-
L
K
--
I
F
D
Y
D
E
T
I
R
P
D
T
T
L
E
S
L
A
A
L
K
P
A
F
N
-
P
--
K
G
G
T
V
T
A
G
T
S
S
Q
I
T
D
G
A
S
C
M
I
V
M
S
A
Q
R
A
K
D
L
G
L
E
P
L
A
V
I
R
S
M
A
V
A
G
V
D
P
A
I
M
G
Y
G
P
V
P
A
T
Q
K
A
L
K
R
A
G
L
N
M
A
D
I
D
F
I
E
L
N
E
A
F
A
A
Q
A
L
P
V
L
K
D
L
K
V
L
---
D
KMN
E
K
V
N
L
H
G
G
A
I
A
L
G
H
P
F
G
C
S
G
A
R
I
S
G
T
L
L
N
V
M
K
Q
N
G
--
G
--
T
-
F
G
L
S
T
M
C
I
G
L
G
Q
G
I
A
T
V
F
E
--
24
PsiBlast_CBE
82.52
45%
-14
- C8 -
1WDL
1
FADA_PSEFR
D:
[5-388]
-
R
D
V
V
I
V
D
F
G
R
T
P
M
G
R
S
K
-
G
-
G
M
H
R
N
T
R
A
E
D
M
S
A
H
L
I
S
K
V
L
E
R
-
N
-
S
----
K
V
D
P
G
-
E
V
E
D
V
I
W
G
C
V
N
Q
T
L
E
Q
G
W
N
I
A
R
M
A
S
L
M
T
Q
I
P
H
T
S
A
A
Q
T
V
S
R
L
C
G
S
S
M
S
A
L
H
T
A
A
Q
A
I
M
T
G
N
G
D
V
F
V
V
G
G
V
E
H
M
G
H
V
S
M
M
-
H
-
G
-
V
D
-------
P
---
N
P
--------------
H
----
M
--
S
L
--------
Y
A
A
---------
K
----------
A
-------------
S
G
M
M
G
L
---
T
A
E
M
L
G
K
M
H
G
I
S
R
E
Q
Q
D
A
F
A
V
R
S
H
Q
L
A
H
K
A
T
V
E
G
K
F
K
D
E
I
I
P
M
Q
------
G
Y
D
E
N
G
F
-
L
K
--
I
F
D
Y
D
E
T
I
R
P
D
T
T
L
E
S
L
A
A
L
K
P
A
F
N
-
P
--
K
G
G
T
V
T
A
G
T
S
S
Q
I
T
D
G
A
S
C
M
I
V
M
S
A
Q
R
A
K
D
L
G
L
E
P
L
A
V
I
R
S
M
A
V
A
G
V
D
P
A
I
M
G
Y
G
P
V
P
A
T
Q
K
A
L
K
R
A
G
L
N
M
A
D
I
D
F
I
E
L
N
E
A
F
A
A
Q
A
L
P
V
L
K
D
L
K
V
L
---
D
KMN
E
K
V
N
L
H
G
G
A
I
A
L
G
H
P
F
G
C
S
G
A
R
I
S
G
T
L
L
N
V
M
K
Q
N
G
--
G
--
T
-
F
G
L
S
T
M
C
I
G
L
G
Q
G
I
A
T
V
F
E
--
108
HHSearch
82.18
45%
-9
- C8 -
4W61
-
BKTB_CUPNH
A:
[2-393]
T
R
E
V
V
V
V
S
G
V
R
T
A
I
G
T
-
F
-
G
-
G
S
L
K
D
V
A
P
A
E
L
G
A
L
V
V
R
E
A
L
A
R
-
A
-
Q
----
V
S
G
-
D
-
D
V
G
H
V
V
F
G
N
V
I
Q
T
E
P
R
D
M
Y
L
G
R
V
A
A
V
N
G
G
V
T
I
N
A
P
A
L
T
V
N
R
L
C
G
S
G
L
Q
A
I
V
S
A
A
Q
T
I
L
L
G
D
T
D
V
A
I
G
G
G
A
E
S
M
S
R
A
P
Y
L
A
P
-
A
-
A
R
WGA----
R
---
M
G
--------------
D
----
A
--
G
L
VD
M
M
L
G
A
L
H
D
P
---------
F
----------
H
-------------
R
I
H
M
G
V
---
T
A
E
N
V
A
K
E
Y
D
I
S
R
A
Q
Q
D
E
A
A
L
E
S
H
R
R
A
S
A
A
I
K
A
G
Y
F
K
D
Q
I
V
P
V
V
S
K
--
G
-------
R
-
K
G
D
V
T
F
D
T
D
E
H
V
R
H
D
A
T
I
D
D
M
T
K
L
R
P
V
F
V
-
K
E-
N
G
-
T
V
T
A
G
N
A
S
G
L
N
D
A
A
A
A
V
V
M
M
E
R
A
E
A
E
R
R
G
L
K
P
L
A
R
L
V
S
Y
G
H
A
G
V
D
P
K
A
M
G
I
G
P
V
P
A
T
K
I
A
L
E
R
A
G
L
Q
V
S
D
L
D
V
I
E
A
N
E
A
F
A
A
Q
A
C
A
V
T
K
A
L
G
L
D
---
P
---
A
K
V
N
P
N
G
S
G
I
S
L
G
H
P
I
G
A
T
G
A
L
I
T
V
K
A
L
H
E
L
N
R
V
Q
--
G
--
R
-
Y
A
L
V
T
M
C
I
G
G
G
Q
G
I
A
A
I
F
E
R
-
20
PsiBlast_PDB
82.16
41%
-10
- C8 -
4XL4
7
?
A:
[1-392]
M
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
-
K
--
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
-
A
-
G
----
I
K
P
-
E
-
D
V
N
E
V
I
L
G
N
V
L
-
Q
A
G
L
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L
A
N
-
N
-
A
R
-------
W
---
G
Y
RMGNAKFVD
E
M
I
T
D
G
----
L
--
W
D
--------
A
F
N
---------
D
----------
Y
-------------
H
M
--
G
I
---
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
V
I
---------
K
G
R
-
K
G
E
T
V
V
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
K
-
K
--
D
G
-
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
A
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
---
M
---
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
--
A
--
K
-
K
G
L
A
T
L
S
I
G
G
G
Q
G
T
A
I
L
L
E
K
C
107
HHSearch
82.12
47%
-8
- C8 -
2IIK
-
THIK_HUMAN
A:
[36-422]
-
A
D
V
V
V
V
H
G
R
R
T
A
I
C
R
-
A
G
R
-
G
G
F
K
D
T
T
P
D
E
L
L
S
A
V
M
T
A
V
L
K
D
-
V
-
N
----
L
R
P
-
E
-
Q
L
G
D
I
C
V
G
N
V
L
Q
P
G
A
-
G
A
I
M
A
R
I
A
Q
F
L
S
D
I
P
E
T
V
P
L
S
T
V
N
R
Q
C
S
S
G
L
Q
A
V
A
S
I
A
G
G
I
R
N
G
S
Y
D
I
G
M
A
C
G
V
E
S
M
S
L
A
D
-----
G
-
N
I
T------
S
R--
L
M
--------------
E
----
K
--
E
---------
K
A
R
---------
D
----------
C
-------------
L
I
P
M
G
I
---
T
S
E
N
V
A
E
R
F
G
I
S
R
E
K
Q
D
T
F
A
L
A
S
Q
Q
K
A
A
R
A
Q
S
K
G
C
F
Q
A
E
I
V
P
V
T
T
T
V
H
D
----
D
K
G
T
-
K
R
S
I
T
V
T
Q
D
E
G
I
R
P
S
T
T
M
E
G
L
A
K
L
K
P
A
F
K
-
K
--
D
G
-
S
T
T
A
G
N
S
S
Q
V
S
D
G
A
A
A
I
L
L
A
R
R
S
K
A
E
E
L
G
L
P
I
L
G
V
L
R
S
Y
A
V
V
G
V
P
P
D
I
M
G
I
G
P
A
Y
A
I
P
V
A
L
Q
K
A
G
L
T
V
S
D
V
D
I
F
E
I
N
E
A
F
A
S
Q
A
A
Y
C
V
E
K
L
R
L
P
---
P
---
E
K
V
N
P
L
G
G
A
V
A
L
G
H
P
L
G
C
T
G
A
R
Q
V
I
T
L
L
N
E
L
K
R
R
G
--
K
R-
A
-
Y
G
V
V
S
M
C
I
G
T
G
M
G
A
A
A
V
F
E
Y
-
22
PsiBlast_CBE
82.11
45%
-12
- C8 -
2D3T
1
FADA_PSEFR
D:
[5-388]
-
R
D
V
V
I
V
D
F
G
R
T
P
M
G
R
S
K
-
G
-
G
M
H
R
N
T
R
A
E
D
M
S
A
H
L
I
S
K
V
L
E
R
-
N
-
S
----
K
V
D
P
G
-
E
V
E
D
V
I
W
G
C
V
N
Q
T
L
E
Q
G
W
N
I
A
R
M
A
S
L
M
T
Q
I
P
H
T
S
A
A
Q
T
V
S
R
L
C
G
S
S
M
S
A
L
H
T
A
A
Q
A
I
M
T
G
N
G
D
V
F
V
V
G
G
V
E
H
M
G
H
V
S
M
M
-
H
-
G
-
V
D
-------
P
---
N
P
--------------
H
----
M
--
S
L
--------
Y
A
A
---------
K
----------
A
-------------
S
G
M
M
G
L
---
T
A
E
M
L
G
K
M
H
G
I
S
R
E
Q
Q
D
A
F
A
V
R
S
H
Q
L
A
H
K
A
T
V
E
G
K
F
K
D
E
I
I
P
M
Q
------
G
Y
D
E
N
G
F
-
L
K
--
I
F
D
Y
D
E
T
I
R
P
D
T
T
L
E
S
L
A
A
L
K
P
A
F
N
-
P
--
K
G
G
T
V
T
A
G
T
S
S
Q
I
T
D
G
A
S
C
M
I
V
M
S
A
Q
R
A
K
D
L
G
L
E
P
L
A
V
I
R
S
M
A
V
A
G
V
D
P
A
I
M
G
Y
G
P
V
P
A
T
Q
K
A
L
K
R
A
G
L
N
M
A
D
I
D
F
I
E
L
N
E
A
F
A
A
Q
A
L
P
V
L
K
D
L
K
V
L
---
D
KMN
E
K
V
N
L
H
G
G
A
I
A
L
G
H
P
F
G
C
S
G
A
R
I
S
G
T
L
L
N
V
M
K
Q
N
G
--
G
--
T
-
F
G
L
S
T
M
C
I
G
L
G
Q
G
I
A
T
V
F
E
--
114
HHSearch
82.08
48%
-13
- C8 -
1ULQ
-
?
A:
[3-399]
--
E
A
W
I
V
E
A
V
R
T
P
I
G
K
-
H
-
G
-
G
A
L
A
S
V
R
P
D
D
L
L
A
H
A
L
S
V
L
V
D
R
-
S
-
G
----
V
P
K
-
E
-
E
V
E
D
V
Y
A
G
C
A
N
Q
A
G
E
D
N
R
N
V
A
R
M
A
L
L
L
A
G
F
P
V
E
V
A
G
C
T
V
N
R
L
C
G
S
G
L
E
A
V
A
Q
A
A
R
A
I
W
A
G
E
G
K
V
Y
I
G
S
G
V
E
S
M
S
R
A
P
Y
A
V
P
-
K
-
P
E
R------
G
F
P
-
T
G
--------------
N
L
---
V
--
M
Y
--------
D
T
T
---------
L
----------
G
WRFVN
P
K
M
Q
A
L
YG
T
E
S
M
G
E
---
T
A
E
N
L
A
E
M
Y
G
I
R
R
E
E
Q
D
R
F
A
L
L
S
H
Q
K
A
V
R
A
W
E
E
G
R
F
Q
D
E
V
V
P
V
P
---------
V
K
R
G
-
K
E
E
I
L
V
E
Q
D
E
G
P
R
R
D
T
S
L
E
K
L
A
A
L
R
P
V
F
R
-
E
--
G
G
-
T
V
T
A
G
N
S
S
P
L
N
D
G
A
A
A
V
L
L
V
S
D
D
Y
A
K
A
H
G
L
R
P
L
A
R
V
R
A
I
A
V
A
G
V
P
P
R
I
M
G
I
G
P
V
P
A
T
R
K
A
L
E
R
A
G
L
S
F
S
D
L
G
L
I
E
L
N
E
A
F
A
A
Q
A
L
A
V
L
R
E
W
S
L
S
ME-
D
---
Q
R
L
N
P
N
G
G
A
I
A
L
G
H
P
L
G
A
S
G
A
R
I
L
T
T
L
V
H
E
M
R
R
R
K
--
V
--
Q
-
F
G
L
A
T
M
C
I
G
V
G
Q
G
I
A
V
V
V
E
G
-
110
HHSearch
82.04
42%
-21
- C8 -
1WL4
7
THIC_HUMAN
A:
[5-397]
S
D
P
V
V
I
V
S
A
A
R
T
I
I
G
S
-
F
-
N
-
G
A
L
A
A
V
P
V
Q
D
L
G
S
T
V
I
K
E
V
L
K
R
-
A
-
T
----
V
A
P
-
E
-
D
V
S
E
V
I
F
G
H
V
L
A
A
G
C
-
G
Q
N
P
V
R
Q
A
S
V
G
A
G
I
P
Y
S
V
P
A
W
S
C
Q
M
I
C
G
S
G
L
K
A
V
C
L
A
V
Q
S
I
G
I
G
D
S
S
I
V
V
A
G
G
M
E
N
M
S
K
A
P
H
L
A
Y
-
L
-
R
T
GV
K
I
G
E
M
P
---
L
T
--------------
D
SILC
D
--
G
L
--------
T
D
A
---------
F
----------
H
-------------
N
C
H
M
G
I
---
T
A
E
N
V
A
K
K
W
Q
V
S
R
E
D
Q
D
K
V
A
V
L
S
Q
N
R
T
E
N
A
Q
K
A
G
H
F
D
K
E
I
V
P
V
L
V
-
S
T
R
K
---------
G
L
I
E
V
K
T
D
E
F
P
R
H
G
S
N
I
E
A
M
S
K
L
K
P
Y
F
L
-
T
DG
T
G
-
T
V
T
P
A
N
A
S
G
I
N
D
G
A
A
A
V
V
L
M
K
K
S
E
A
D
K
R
G
L
T
P
L
A
R
I
V
S
W
S
Q
V
G
V
E
P
S
I
M
G
I
G
P
I
P
A
I
K
Q
A
V
T
K
A
G
W
S
L
E
D
V
D
I
F
E
I
N
E
A
F
A
A
V
S
A
A
I
V
K
E
L
G
L
N
---
P
---
E
K
V
N
I
E
G
G
A
I
A
L
G
H
P
L
G
A
S
G
C
R
I
L
V
T
L
L
H
T
L
E
R
M
G
--
R
--
S
-
R
G
V
A
A
L
C
I
G
G
G
M
G
I
A
M
C
V
Q
R
E
19
PsiBlast_PDB
80.95
41%
-10
- C8 -
4XL3
4
?
A:
[1-392]
M
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
-
K
--
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
-
A
-
G
----
I
K
P
-
E
-
D
V
N
E
V
I
L
G
N
V
L
-
Q
A
G
L
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L
A
N
-
N
-
A
R
-------
W
---
G
Y
RMGNAKFVDEMITD
G
----
L
--
W
D
--------
A
F
N
---------
D
----------
Y
-------------
H
M
--
G
I
---
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
V
I
---------
K
G
R
-
K
G
E
T
V
V
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
K
-
K
--
D
G
-
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
A
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
---
M
---
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
--
A
--
K
-
K
G
L
A
T
L
S
I
G
G
G
Q
G
T
A
I
L
L
E
K
C
34
PsiBlast_CBE
80.88
41%
-12
- C8 -
4XL4
4
?
B:
[1-392]
M
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
-
K
--
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
-
A
-
G
----
I
K
P
-
E
-
D
V
N
E
V
I
L
G
N
V
L
-
Q
A
G
L
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L
A
N
-
N
-
A
R
-------
W
---
G
Y
RMGNAKFVDEMITD
G
----
L
--
W
D
--------
A
F
N
---------
D
----------
Y
-------------
H
M
--
G
I
---
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
V
I
---------
K
G
R
-
K
G
E
T
V
V
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
K
-
K
--
D
G
-
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
A
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
---
M
---
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
--
A
--
K
-
K
G
L
A
T
L
S
I
G
G
G
Q
G
T
A
I
L
L
E
K
C
35
PsiBlast_CBE
80.34
41%
-10
- C8 -
4XL3
3
?
B:
[1-392]
M
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
-
K
--
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
-
A
-
G
----
I
K
P
-
E
-
D
V
N
E
V
I
L
G
N
V
L
-
Q
A
G
L
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L
A
N
-
N
-
A
R
-------
W
---
G
Y
RMGNAKFVDEMITD
G
----
L
--
W
D
--------
A
F
N
---------
D
----------
Y
-------------
H
M
--
G
I
---
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
V
I
---------
K
G
R
-
K
G
E
T
V
V
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
K
-
K
--
D
G
-
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
A
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
---
M
---
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
--
A
--
K
-
K
G
L
A
T
L
S
I
G
G
G
Q
G
T
A
I
L
L
E
K
C
32
PsiBlast_CBE
79.50
41%
-15
- C8 -
4XL2
7
THLA_CLOAB
A:
[1-392]
M
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
-
K
--
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
-
A
-
G
----
I
K
P
-
E
-
D
V
N
E
V
I
L
G
N
V
L
-
Q
A
G
L
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L
A
N
-
N
-
A
R
-------
W
---
G
Y
RMGNAKFVD
E
M
I
T
D
G
----
L
--
W
D
--------
A
F
N
---------
D
----------
Y
-------------
H
M
--
G
I
---
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
V
I
---------
K
G
R
-
K
G
E
T
V
V
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
K
-
K
--
D
G
-
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
---------
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
---
M
---
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
--
A
--
K
-
K
G
L
A
T
L
C
I
G
G
G
Q
G
T
A
I
L
L
E
K
C
16
PsiBlast_PDB
79.18
41%
-8
- C8 -
4WYR
5
THLA_CLOAB
A:
[1-392]
M
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
-
K
--
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
-
A
-
G
----
I
K
P
-
E
-
D
V
N
E
V
I
L
G
N
V
L
-
Q
A
G
L
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
Q
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L
A
N
-
N
-
A
R
-------
W
---
G
Y
--------------
R
----
M
GN
A
K
--------
F
V
D
---------
E
M
I
T
D
GLWDAF
Y
-------------
D
Y
H
M
G
I
---
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
V
I
---------
K
G
R
-
K
G
E
T
V
V
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
K
-
K
--
D
G
-
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
K
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
---
M
---
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
--
A
--
K
-
K
G
L
A
T
L
C
I
G
G
G
Q
G
T
A
I
L
L
E
K
C
31
PsiBlast_CBE
78.73
41%
-14
- C8 -
4XL2
7
THLA_CLOAB
B:
[1-392]
M
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
-
K
--
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
-
A
-
G
----
I
K
P
-
E
-
D
V
N
E
V
I
L
G
N
V
L
-
Q
A
G
L
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L
A
N
-
N
-
A
R
-------
W
---
G
Y
RMGNAKFVDEMITD
G
----
L
--
W
D
--------
A
F
N
---------
D
----------
Y
-------------
H
M
--
G
I
---
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
V
I
---------
K
G
R
-
K
G
E
T
V
V
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
K
-
K
--
D
G
-
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
---------
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
---
M
---
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
--
A
--
K
-
K
G
L
A
T
L
C
I
G
G
G
Q
G
T
A
I
L
L
E
K
C
94
PsiBlast_CBE
77.94
38%
-2
- C8 -
4UBW
21
?
A:
[9-397]
M
G
Y
P
V
I
V
E
A
T
R
S
P
I
G
K
-
R
-
N
-
G
W
L
S
G
L
H
A
T
E
L
L
G
A
V
Q
K
A
V
V
D
K
-
A
-
G
IQSG
L
H
A
-
G
-
D
V
E
Q
V
I
G
G
C
V
T
Q
F
G
E
Q
S
N
N
I
S
R
V
A
W
L
T
A
G
L
P
E
H
V
G
A
T
T
V
D
C
Q
C
G
S
G
Q
Q
A
N
H
L
I
A
G
L
I
A
A
G
A
I
D
V
G
I
A
C
G
I
E
A
M
S
R
V
G
L
-
G
A
-
N
-
A
G
-------
P
---
D
R
--------------------------------------------
S
----------
W
-------------
D
I
D
L
P
N
Q
F
E
A
A
E
R
I
A
K
R
R
G
I
T
R
E
D
V
D
V
F
G
L
E
S
Q
R
R
A
Q
R
A
W
A
E
G
R
F
D
R
E
I
S
P
I
Q
A
P
V
L
D
--
E
Q
N
Q
P
T
G
E
R
R
L
V
F
-
R
D
Q
G
L
R
E
T
T
M
A
G
-
L
G
E
L
K
P
V
L
E
----
G
G
-
I
H
T
A
G
T
S
S
Q
I
S
D
G
A
A
A
V
L
W
M
D
E
A
V
A
R
A
H
G
L
T
P
R
A
R
I
V
A
Q
A
L
V
G
A
E
P
Y
Y
H
L
D
G
P
V
Q
S
T
A
K
V
L
E
K
A
G
M
K
I
G
D
I
D
I
V
E
I
N
E
A
F
A
S
V
V
L
S
W
A
R
V
H
E
P
D
---
M
---
D
R
V
N
V
N
G
G
A
I
A
L
G
H
P
V
G
C
T
G
S
R
L
I
T
T
A
L
H
E
L
E
R
T
D
--
Q
--
S
-
L
A
L
I
T
M
C
A
G
G
A
L
S
T
G
T
I
I
E
--
95
PsiBlast_CBE
77.58
38%
1
- C8 -
4UBV
14
?
B:
[9-397]
M
G
Y
P
V
I
V
E
A
T
R
S
P
I
G
K
-
R
-
N
-
G
W
L
S
G
L
H
A
T
E
L
L
G
A
V
Q
K
A
V
V
D
K
-
A
-
G
IQSG
L
H
A
-
G
-
D
V
E
Q
V
I
G
G
C
V
T
Q
F
G
E
Q
S
N
N
I
S
R
V
A
W
L
T
A
G
L
P
E
H
V
G
A
T
T
V
D
C
Q
-
G
S
G
Q
Q
A
N
H
L
I
A
G
L
I
A
A
G
A
I
D
V
G
I
A
C
G
I
E
A
M
S
R
V
G
L
-
G
A
-
N
-
A
G
-------
P
---
D
R
--------------
S
----
L
--
I
---------
R
A
Q
---------
S
----------
W
-------------
D
I
D
L
P
N
Q
F
E
A
A
E
R
I
A
K
R
R
G
I
T
R
E
D
V
D
V
F
G
L
E
S
Q
R
R
A
Q
R
A
W
A
E
G
R
F
D
R
E
I
S
P
I
Q
A
P
V
L
D
--
E
Q
N
Q
P
T
G
E
R
R
L
V
F
-
R
D
Q
G
L
R
E
T
T
M
A
G
-
L
G
E
L
K
P
V
L
E
----
G
G
-
I
H
T
A
G
T
S
S
Q
I
S
D
G
A
A
A
V
L
W
M
D
E
A
V
A
R
A
H
G
L
T
P
R
A
R
I
V
A
Q
A
L
V
G
A
E
P
Y
Y
H
L
D
G
P
V
Q
S
T
A
K
V
L
E
K
A
G
M
K
I
G
D
I
D
I
V
E
I
N
E
A
F
A
S
V
V
L
S
W
A
R
V
H
E
P
D
---
M
---
D
R
V
N
V
N
G
G
A
I
A
L
G
H
P
V
G
C
T
G
S
R
L
I
T
T
A
L
H
E
L
E
R
T
D
--
Q
--
S
-
L
A
L
I
T
M
C
A
G
G
A
L
S
T
G
T
I
I
E
--
30
PsiBlast_CBE
76.75
41%
-7
- C8 -
4WYR
3
THLA_CLOAB
B:
[1-392]
M
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
G
-
K
--
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
-
A
-
G
----
I
K
P
-
E
-
D
V
N
E
V
I
L
G
N
V
L
-
Q
A
G
L
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
Q
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L
A
N
-
N
-
A
R
-------
W
---
G
Y
--------------
R
----
M
GN
A
K
--------
F
V
D
---------
E
MITDGLWDAF
Y
-------------
D
Y
H
M
G
I
---
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
V
I
---------
K
G
R
-
K
G
E
T
V
V
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
K
-
K
--
D
G
-
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
K
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
---
M
---
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
--
A
--
K
-
K
G
L
A
T
L
C
I
G
G
G
Q
G
T
A
I
L
L
E
K
C