@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu32940: (2016-07-25 )
MGMSAISTETLSLGYGDAVIIDELNLTIPKGEITVFIGSNGCGKSTLLRSLARLMKPRGGSVLLEGRAIAKLPTKEVAKELAILPQGPSAPEGLTVHQLVKQGRYPYQNWLKQWSKEDEEAVERALKATKLEDMADRAVDSLSGGQRQRAWIAMTLAQETDIILLDEPTTYLDMTHQIEILDLLFELNEKEDRTIVMVLHDLNLACRYAHHLVAIKDKRIYAEGRPEEVITCDLVQNVFSMNCQVTQDPLFGTPLCIPHGRGRCIVQEAAFTSHG
Atome Classification :
(30 SA)
.........10........20........30........40........50........60........----70-.--....-------------...----80........90.....-...100..-.....110.......---120.......130------.......----140---........150......------.160-----.........170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGMSAIS
T
E
T
L
SLGYG
D
A
V
I
I
DE
L
N
L
T
IPK
G
E
I
T
V
F
IGSNGC
G
K
S
T
L
L
R
S
L
A
R
L
MKPRG
G
S
V
L
LEG
R
A
I
----AK-L--
P
T
K
E
-------------
V
A
K
----
E
L
AILPQGPSAPEG
L
T
V
-
H
Q
L
V
K
QGR-
Y
P
Y
Q
N
W
L
K
Q
WSKE
D
E
---
E
A
V
E
R
A
L
K
A
T
K
L
E
------
D
M
A
D
R
A
V
----
D
S----LSGGQ
R
Q
R
A
W
I
A
M
T
LAQ------ET-------
D
I
I
L
LDEPT
T
Y
L
DM
T
H
Q
I
E
I
L
D
L
L
F
ELNEKED
R
T
I
V
M
V
L
HDL
N
L
A
C
R
Y
AH
H
L
V
A
I
K
D
K
R
I
YAEGRPE
E
V
I
T
C
D
L
V
Q
N
V
F
SMN
C
Q
VTQDPLFGTPLCIPHGRG
R
C
I
V
Q
EAAFTSHG
21
PsiBlast_CBE
87.11
32%
-61
- C1 -
4G1U
1
HMUV_YERPE
D:
[26-260]
-------------------
L
I
N
D
V
S
L
H
I
A
S
G
E
M
V
A
I
I
G
P
N
G
A
G
K
S
T
L
L
R
L
L
T
G
Y
L
S
P
S
H
G
E
C
H
L
L
G
Q
N
L
----
N
S
-
W
--
Q
P
K
A
-------------
L
A
R
----
T
R
A
V
M
R
Q
Y
S
E
L
A
F
P
F
S
V
-
S
E
V
I
Q
M
G
R
-
A
P
Y
G
G
------
S
Q
D
R
---
Q
A
L
Q
Q
V
M
A
Q
T
D
C
L
------
A
L
A
Q
R
D
Y
----
R
V
----
L
S
G
G
E
Q
Q
R
V
Q
L
A
R
V
L
A
Q
LWQPQP
T
P
-------
R
W
L
F
L
D
E
P
T
S
A
L
D
L
Y
H
Q
Q
H
T
L
R
L
L
R
Q
L
T
R
Q
E
P
L
A
V
C
C
V
L
H
D
L
N
L
A
A
L
Y
A
D
R
I
M
L
L
A
Q
G
K
L
V
A
C
G
T
P
E
E
V
L
N
A
E
T
L
T
Q
W
Y
Q
A
D
L
G
V
S
R
H
P
E
S
A
L
P
---------------------
1
PsiBlast_PDB
87.09
32%
-62
- C1 -
4G1U
1
HMUV_YERPE
C:
[26-260]
-------------------
L
I
N
D
V
S
L
H
I
A
S
G
E
M
V
A
I
I
G
P
N
G
A
G
K
S
T
L
L
R
L
L
T
G
Y
L
S
P
S
H
G
E
C
H
L
L
G
Q
N
L
----
N
S
-
W
--
Q
P
K
A
-------------
L
A
R
----
T
R
A
V
M
R
Q
Y
S
E
L
A
F
P
F
S
V
-
S
E
V
I
Q
M
G
R
-
A
P
Y
G
G
------
S
Q
D
R
---
Q
A
L
Q
Q
V
M
A
Q
T
D
C
L
------
A
L
A
Q
R
D
Y
----
R
V
----
L
S
G
G
E
Q
Q
R
V
Q
L
A
R
V
L
A
Q
L
WQPQP
T
P
-------
R
W
L
F
L
D
E
P
T
S
A
L
D
L
Y
H
Q
Q
H
T
L
R
L
L
R
Q
L
T
R
Q
E
P
L
A
V
C
C
V
L
H
D
L
N
L
A
A
L
Y
A
D
R
I
M
L
L
A
Q
G
K
L
V
A
C
G
T
P
E
E
V
L
N
A
E
T
L
T
Q
W
Y
Q
A
D
L
G
V
S
R
H
P
E
S
A
L
P
---------------------
61
HHSearch
78.97
28%
-136
- C1 -
3RLF
3
MALK_ECOLI
A:
[2-225]
---
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
D
-
T
--
P
--
P
-------------
A
E
R
----
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
-
A
E
N
M
S
F
G
L
-
K
L
A
G
----
A
K
K
E
V
I
N
---
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
------
H
L
L
D
R
K
P
----
K
A
----
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
------
E
P
-------
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
------------------------------------------
7
PsiBlast_PDB
77.63
32%
-60
- C1 -
4U02
1
?
A:
[5-227]
-----
I
R
I
R
N
L
H
K
W
F
G
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
----
K
D
D
R
--
A
L
R
E
-------------
I
R
R
----
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
-
L
E
N
V
T
L
A
P
-
M
R
V
R
R
W
P
R
E
--
K
A
E
K
---
K
A
L
E
-
L
L
E
R
V
G
I
L
------
D
Q
A
R
K
Y
P
----
A
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
------
E
P
-------
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
--------------------------------------------
23
PsiBlast_CBE
75.23
32%
-60
- C1 -
4U02
1
?
C:
[5-227]
-----
I
R
I
R
N
L
H
K
W
F
G
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
----
K
D
D
R
--
A
L
R
E
-------------
I
R
R
----
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
-
L
E
N
V
T
L
A
P
-
M
R
V
R
R
W
P
R
E
--
K
A
E
K
---
K
A
L
E
-
L
L
E
R
V
G
I
L
------
D
Q
A
R
K
Y
P
----
A
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
------
E
P
-------
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
--------------------------------------------
6
PsiBlast_PDB
74.60
32%
-57
- C1 -
4U00
3
?
A:
[5-227]
-----
I
R
I
R
N
L
H
K
W
F
G
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
----
K
D
D
R
--
A
L
R
E
-------------
I
R
R
----
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
-
L
E
N
V
T
L
A
P
-
M
R
V
R
R
W
P
R
E
--
K
A
E
K
---
K
A
L
E
-
L
L
E
R
V
G
I
L
------
D
Q
A
R
K
Y
P
----
A
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
------
E
P
-------
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
--------------------------------------------
19
PsiBlast_PDB
74.12
29%
-73
- C1 -
3RLF
3
MALK_ECOLI
A:
[2-221]
---
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
D
-
T
--
P
P
A
E
---------------
R
----
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
-
A
E
N
M
S
F
G
--------
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
------
H
L
L
D
R
K
P
----
K
A
----
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
------
E
P
-------
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
----------------------------------------------
24
PsiBlast_CBE
73.72
32%
-60
- C1 -
4U02
1
?
B:
[5-227]
-----
I
R
I
R
N
L
H
K
W
F
G
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
----
K
D
D
R
--
A
L
R
E
-------------
I
R
R
----
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
-
L
E
N
V
T
L
A
P
-
M
R
V
R
R
W
P
R
E
--
K
A
E
K
---
K
A
L
E
-
L
L
E
R
V
G
I
L
------
D
Q
A
R
K
Y
P
----
A
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
------
E
P
-------
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
--------------------------------------------
22
PsiBlast_CBE
73.21
32%
-51
- C1 -
4U02
1
?
D:
[5-227]
-----
I
R
I
R
N
L
H
K
W
F
G
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
----
K
D
D
R
--
A
L
R
E
-------------
I
R
R
----
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
-
L
E
N
V
T
L
A
P
-
M
R
V
R
R
W
P
R
E
--
K
A
E
K
---
K
A
L
E
-
L
L
E
R
V
G
I
L
------
D
Q
A
R
K
Y
P
----
A
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
------
E
P
-------
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
--------------------------------------------
16
PsiBlast_PDB
71.81
29%
-72
- C1 -
3PUV
5
MALK_ECOLI
A:
[2-221]
---
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
D
-
T
--
P
P
A
E
---------------
R
----
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
-
A
E
N
M
S
F
G
--------
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
------
H
L
L
D
R
K
P
----
K
A
----
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
------
E
P
-------
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
----------------------------------------------
33
PsiBlast_CBE
71.67
31%
-21
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[3-226]
---
A
A
L
H
I
G
H
L
S
K
S
F
Q
N
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
FSKN
T
N
-
L
--
P
V
R
E
---------------
R
----
R
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
-
Y
R
N
I
A
----
Y
G
L
G
N
G
-
K
G
R
T
A
Q
E
R
---
Q
R
I
E
A
M
L
E
L
T
G
I
S
------
E
L
A
G
R
Y
P
----
H
E
----
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
------
D
P
-------
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
----------------------------------------------
34
PsiBlast_CBE
71.51
31%
-21
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[3-231]
---
A
A
L
H
I
G
H
L
S
K
S
F
Q
N
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
FSKN
T
N
-
L
--
P
V
R
E
---------------
R
----
R
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
-
Y
R
N
I
A
----
Y
G
L
G
N
G
-
K
G
R
T
A
Q
E
R
---
Q
R
I
E
A
M
L
E
L
T
G
I
S
------
E
L
A
G
R
Y
P
----
H
E
----
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
------
D
P
-------
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
----------------------------------------------
13
PsiBlast_PDB
71.24
29%
-68
- C1 -
3PUY
3
MALK_ECOLI
A:
[2-221]
---
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
D
-
T
--
P
P
A
E
---------------
R
----
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
-
A
E
N
M
S
F
G
--------
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
------
H
L
L
D
R
K
P
----
K
A
----
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
------
E
P
-------
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
----------------------------------------------
58
HHSearch
70.98
28%
-123
- C1 -
1V43
-
?
A:
[9-239]
-
K
M
V
E
V
K
L
E
N
L
T
K
R
F
G
N
F
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
R
D
V
----
T
Y
-
L
--
P
P
---------------
K
D
R
----
N
I
S
M
V
F
Q
------
H
M
T
V
-
Y
E
N
I
A
F
P
L
---
K
K
----
F
P
K
D
E
I
D
---
K
R
V
R
W
A
A
E
L
L
Q
I
E
------
E
L
L
N
R
Y
P
----
A
Q
----
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
------
E
P
-------
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
-------------------------------------------
18
PsiBlast_PDB
70.72
29%
-68
- C1 -
3PUX
5
MALK_ECOLI
A:
[2-221]
---
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
D
-
T
--
P
P
A
E
---------------
R
----
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
-
A
E
N
M
S
F
G
--------
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
------
H
L
L
D
R
K
P
----
K
A
----
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
------
E
P
-------
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
----------------------------------------------
17
PsiBlast_PDB
70.32
29%
-72
- C1 -
3PUW
5
MALK_ECOLI
A:
[2-221]
---
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
D
-
T
--
P
P
A
E
---------------
R
----
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
-
A
E
N
M
S
F
G
--------
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
------
H
L
L
D
R
K
P
----
K
A
----
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
------
E
P
-------
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
----------------------------------------------
57
HHSearch
69.79
28%
-119
- C1 -
2IT1
-
?
A:
[2-225]
---
V
E
I
K
L
E
N
I
V
K
K
F
G
N
F
T
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
K
D
V
----
T
E
-
L
--
P
P
---------------
K
D
R
----
N
V
G
L
V
F
Q
N
W
A
L
Y
P
H
M
T
V
-
Y
K
N
I
A
F
P
L
-
E
L
R
K
----
A
P
R
E
E
I
D
---
K
K
V
R
E
V
A
K
M
L
H
I
D
------
K
L
L
N
R
Y
P
----
W
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
------
E
P
-------
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
Y
K
P
------------------------------------------
14
PsiBlast_PDB
69.30
29%
-74
- C1 -
3PUZ
2
MALK_ECOLI
A:
[2-221]
---
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
D
-
T
--
P
P
A
E
---------------
R
----
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
-
A
E
N
M
S
F
G
--------
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
------
H
L
L
D
R
K
P
----
K
A
----
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
------
E
P
-------
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
----------------------------------------------
56
HHSearch
68.35
30%
-32
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[2-234]
--
T
A
A
L
H
I
G
H
L
S
K
S
F
Q
N
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
----
F
S
-
K
N
T
N
L
P
V
-------------
R
E
R
----
R
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
-
Y
R
N
I
A
Y
G
L
-
G
N
G
K
G
----
R
T
A
Q
E
R
---
Q
R
I
E
A
M
L
E
L
T
G
I
S
------
E
L
A
G
R
Y
P
----
H
E
----
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
------
D
P
-------
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
-------------------------------------------
20
PsiBlast_PDB
68.11
29%
-69
- C1 -
4JBW
-
MALK_ECOLI
A:
[2-221]
---
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
D
-
T
--
P
P
A
E
---------------
R
----
G
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
-
A
E
N
M
S
F
G
--------
L
K
L
A
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
------
H
L
L
D
R
K
P
----
K
A
----
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
------
E
P
-------
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
----------------------------------------------
47
PsiBlast_CBE
65.20
32%
-35
- C1 -
1B0U
4
HISP_SALTY
A:
[16-241]
--------------
Y
G
G
H
E
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
----
N
L
-
V
--
R
D
K
D
GQLKVAD
K
N
Q
L
R
L
L
R
T
----
R
L
T
M
V
F
Q
H
F
N
L
W
S
H
M
T
V
-
L
E
N
V
M
E
A
---
P
I
Q
--
V
L
G
L
S
K
H
D
-----
A
R
E
R
A
L
K
Y
L
A
K
V
------
G
I
D
E
R
A
Q
----
G
K
YPVH
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
------
E
P
-------
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
-
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
---------------------------------------------
28
PsiBlast_CBE
60.99
32%
-18
- C1 -
4YMU
2
?
A:
[11-224]
--------------
F
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
NN--
G
K
-
V
--
N
I
N
K
-------------
V
R
Q
----
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
-
I
E
N
I
T
L
A
P
-
V
K
V
K
---
K
M
N
K
K
E
A
E
---
E
L
A
V
D
L
L
A
K
V
G
L
L
------
D
K
K
D
Q
Y
P
----
I
K
----
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
------
Q
P
-------
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
---------------------------------------------
26
PsiBlast_CBE
60.91
32%
-21
- C1 -
4YMV
1
?
A:
[11-224]
--------------
F
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
NN--
G
K
-
V
--
N
I
N
K
-------------
V
R
Q
----
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
-
I
E
N
I
T
L
A
P
-
V
K
V
K
---
K
M
N
K
K
E
A
E
---
E
L
A
V
D
L
L
A
K
V
G
L
L
------
D
K
K
D
Q
Y
P
----
I
K
----
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
------
Q
P
-------
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
---------------------------------------------
39
PsiBlast_CBE
59.84
31%
-33
- C1 -
4R9U
3
BTUD_ECOLI
D:
[23-233]
---------------------------
V
R
A
G
E
I
L
H
L
V
G
P
N
G
A
G
K
S
T
L
L
A
R
M
A
G
M
T
S
G
K
G
-
S
I
Q
F
A
G
Q
P
L
----
E
A
-
W
--
S
A
T
K
-------------
L
A
L
----
H
R
A
Y
L
S
Q
Q
Q
T
P
P
F
A
T
P
V
W
H
Y
L
T
-----------
L
H
Q
H
D
K
T
R
T
---
E
L
L
N
D
V
A
G
A
L
A
L
D
------
D
K
L
G
R
S
T
----
N
Q
----
L
S
G
G
E
W
Q
R
V
R
L
A
A
V
V
L
Q
------
I
T
PQANPAG
Q
L
L
L
L
D
Q
P
M
C
S
L
D
V
A
Q
Q
-
S
A
L
D
K
I
L
S
A
L
S
Q
Q
G
L
A
I
V
M
S
S
H
D
L
N
H
T
L
R
H
A
H
R
A
W
L
L
K
G
G
K
M
L
A
S
G
R
R
E
E
V
L
T
P
P
N
L
A
Q
A
Y
G
M
N
---------------------------------
27
PsiBlast_CBE
59.59
32%
-15
- C1 -
4YMU
2
?
J:
[11-224]
--------------
F
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
NN--
G
K
-
V
--
N
I
N
K
-------------
V
R
Q
----
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
-
I
E
N
I
T
L
A
P
-
V
K
V
K
---
K
M
N
K
K
E
A
E
---
E
L
A
V
D
L
L
A
K
V
G
L
L
------
D
K
K
D
Q
Y
P
----
I
K
----
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
------
Q
P
-------
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
---------------------------------------------
40
PsiBlast_CBE
59.30
31%
-34
- C1 -
4R9U
3
BTUD_ECOLI
C:
[23-233]
---------------------------
V
R
A
G
E
I
L
H
L
V
G
P
N
G
A
G
K
S
T
L
L
A
R
M
A
G
M
T
S
G
K
G
-
S
I
Q
F
A
G
Q
P
L
----
E
A
-
W
--
S
A
T
K
-------------
L
A
L
----
H
R
A
Y
L
S
Q
Q
Q
T
P
P
F
A
T
P
V
W
H
Y
L
T
-----------
L
H
Q
H
D
K
T
R
T
---
E
L
L
N
D
V
A
G
A
L
A
L
D
------
D
K
L
G
R
S
T
----
N
Q
----
L
S
G
G
E
W
Q
R
V
R
L
A
A
V
V
L
Q
------
I
T
PQANPAG
Q
L
L
L
L
D
Q
P
M
C
S
L
D
V
A
Q
Q
-
S
A
L
D
K
I
L
S
A
L
S
Q
Q
G
L
A
I
V
M
S
S
H
D
L
N
H
T
L
R
H
A
H
R
A
W
L
L
K
G
G
K
M
L
A
S
G
R
R
E
E
V
L
T
P
P
N
L
A
Q
A
Y
G
M
N
---------------------------------
25
PsiBlast_CBE
58.20
32%
-13
- C1 -
4YMV
1
?
J:
[11-224]
--------------
F
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
NN--
G
K
-
V
--
N
I
N
K
-------------
V
R
Q
----
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
L
T
A
-
I
E
N
I
T
L
A
P
-
V
K
V
K
---
K
M
N
K
K
E
A
E
---
E
L
A
V
D
L
L
A
K
V
G
L
L
------
D
K
K
D
Q
Y
P
----
I
K
----
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
------
Q
P
-------
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
---------------------------------------------
31
PsiBlast_CBE
57.58
31%
-0
- C1 -
3TIF
7
Y796_METJA
B:
[8-226]
-------
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
----
N
D
-
L
--
D
D
D
E
-------------
L
T
K
IRRD
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
-
L
E
N
V
E
L
P
L
I
F
K
Y
R
G
A
M
-----
S
G
E
---
E
R
R
K
R
A
L
E
C
L
K
M
A
------
E
L
E
E
R
F
A
NHKP
N
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
------
N
P
-------
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
----------------------------------------------------
45
PsiBlast_CBE
40.68
32%
-124
- C1 -
3J15
1
?
B:
[365-535]
---------------------------
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
E
G
K
V
--------------------
E
-------------
W
D
L
----
T
V
A
Y
K
P
Q
Y
I
K
A
E
Y
E
G
T
V
-
Y
E
L
L
S
K
I
D
-
S
S
K
L
N
--
S
N
F
Y
K
T
E
---------
L
L
K
P
L
G
I
I
------
D
L
Y
D
R
N
V
----
E
D
----
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
------
D
A
-------
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
T
A
L
V
V
E
H
D
V
-
L
M
I
D
Y
------
V
S
D
R
L
I
V
F
E
G
E
P
-------------------------------------------------
46
PsiBlast_CBE
27.80
32%
-25
- C1 -
3BK7
1
?
A:
[379-549]
---------------------------
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
E
G
K
V
--------------------
E
-------------
W
D
L
----
T
V
A
Y
K
P
Q
Y
I
K
A
E
Y
E
G
T
V
-
Y
E
L
L
---------------
S
K
I
D
S
---
S
K
L
N
S
N
F
Y
K
T
E
L
L
KPLGII
D
L
Y
D
R
N
V
----
E
D
----
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
------
D
A
-------
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
N
E
K
T
A
L
V
V
E
H
D
V
-
L
M
I
D
Y
------
V
S
D
R
L
I
V
F
E
G
E
P
-------------------------------------------------