@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu33190: (2016-07-25 )
MDLQLKEKLVLITGSTSGIGKAAAKSFLQEGAAVIVNGRKQETVDRTIEELSGYGTVHGAAADLSKTDEAAAFIEKVNEIGDIDILVNNLGFFEVKDFADVTDEEWNQYFEVNVMSAVRTSRHFLPKMLAKNSGRILNIASEAGVKPLPTMIPYSMTKTALISLSRGMAEMTKGTNVTVNSVLPGPTWTEGVASYMEGAAQAAGQDTDTFIKDYFKVNEPTSLIQRYATAEEVANTIVFLASDAASAINGTAQRVEGGIIRSL
Atome Classification :
(21 SA)
.........10........20........30........40-....---....50--...---..--...60--........70....-..-..-80........90....--....100.......110.......120.......130........140.......-150.......160.......170.......180...----....190.......200......---.210.-...-...220.......230.......240.......250.......260.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDL
Q
L
K
E
K
L
V
L
I
TGSTSG
I
G
K
A
A
A
K
S
F
L
QEG
A
A
V
I
VNGRK
Q
-
E
T
V
D
---
R
T
I
E
E
L
--SGY---GT--VHGAA--ADLSK
T
D
E
A
A
A
F
I
E
-
K
V
-
N
E-IG
D
I
D
I
L
VNNLG
F
F
E
V
--
K
D
FADV
T
D
E
E
W
N
Q
Y
F
E
V
N
V
M
S
A
V
R
T
S
R
H
F
L
P
K
M
L
AK-NSG
R
I
L
N
I
A
S
EAGVKPLP-TMIPY
S
M
T
K
T
A
L
I
S
L
S
R
G
M
A
E
MTKGT
N
V
T
V
NSVLPG----P
T
W
T
E
G
V
A
S
Y
M
E
G
A
A
QAAGQ
D
T
D
---
T
F
I
K
D
-
Y
FK-VN
E
P
T
S
L
I
Q
R
Y
A
T
A
E
E
V
A
N
T
I
V
F
L
AS
D
A
A
S
AING
T
A
Q
R
VEGGIIRSL
1
PsiBlast_PDB
78.51
44%
-16
- C1 -
3T4X
-
?
A:
[4-263]
---
Q
L
K
G
K
T
A
L
V
T
G
S
T
A
G
I
G
K
A
I
A
T
S
L
V
A
E
G
A
N
V
L
I
N
G
R
R
E
-
E
N
V
N
---
E
T
I
K
E
I
--
R
A
Q
YPD
A
I
--
L
Q
P
V
V
--
A
D
L
G
T
E
Q
G
C
Q
D
V
I
E
-
K
Y
-
P
K
-
V
---
D
I
L
I
N
N
L
G
I
F
E
P
--
V
E
Y
F
D
I
P
D
E
D
W
F
K
L
F
E
V
N
I
M
S
G
V
R
L
T
R
S
Y
L
K
K
M
I
E
R
-
K
E
G
R
V
I
F
I
A
S
E
A
A
I
M
P
S
Q
-
E
M
A
H
Y
S
A
T
K
T
M
Q
L
S
L
S
R
S
L
A
E
L
T
T
G
T
N
V
T
V
N
T
I
M
P
G
----
S
T
L
T
E
G
V
E
T
M
L
N
S
L
Y
P
N
E
Q
L
T
I
E
---
E
A
E
K
R
-
F
M
K
-
E
N
R
P
T
S
I
I
Q
R
L
I
R
P
E
E
I
A
H
L
V
T
F
L
S
S
P
L
S
S
A
I
N
G
S
A
L
R
I
D
G
G
L
V
R
S
V
122
HHSearch
76.62
33%
-29
- C1 -
3AI3
3
?
A:
[1-262]
M
D
M
G
I
S
G
K
V
A
V
I
T
G
S
S
S
G
I
G
L
A
I
A
E
G
F
A
K
E
G
A
H
I
V
L
V
A
R
Q
V
-
D
R
L
H
---
E
A
A
R
S
L
K
E
K
F
G
---
V
R
--
V
L
E
V
A
--
V
D
V
A
T
P
E
G
V
D
A
V
V
E
S
V
R
-
S
S
-
F
G
G
A
D
I
L
V
N
N
A
G
T
G
S
N
--
E
T
I
M
E
A
A
D
E
K
W
Q
F
Y
W
E
L
L
V
M
A
A
V
R
L
A
R
G
L
V
P
G
M
R
A
R
-
G
G
G
A
I
I
H
N
A
S
I
C
A
V
Q
P
L
W
-
Y
E
P
I
Y
N
V
T
K
A
A
L
M
M
F
S
K
T
L
A
T
E
V
I
K
D
N
I
R
V
N
C
I
N
P
G
----
L
I
L
T
P
D
W
I
K
T
A
K
E
L
T
K
D
N
G
G
D
W
K
---
G
Y
L
Q
S
V
A
D
E
-----
H
A
P
I
K
R
F
A
S
P
E
E
L
A
N
F
F
V
F
L
C
S
E
R
A
T
Y
S
V
G
S
A
Y
F
V
D
G
G
M
L
K
T
-
119
HHSearch
74.54
27%
-56
- C1 -
3WDS
4
?
A:
[7-262]
-
I
F
D
L
S
G
R
K
A
I
V
T
G
G
S
K
G
I
G
A
A
I
A
R
A
L
D
K
A
G
A
T
V
A
I
A
D
L
D
V
-
M
A
A
Q
---
A
V
V
A
G
L
----
E
---
N
G
--
G
F
A
V
E
--
V
D
V
T
K
R
A
S
V
D
A
A
M
Q
K
A
I
-
D
A
-
L
G
G
F
D
L
L
C
A
N
A
G
V
S
T
M
--
R
P
A
V
D
I
T
D
E
E
W
D
F
N
F
D
V
N
A
R
G
V
F
L
A
N
Q
I
A
C
R
H
F
L
A
S
N
T
K
G
V
I
V
N
T
A
S
L
A
A
K
V
G
A
P
-
L
L
A
H
Y
S
A
S
K
F
A
V
F
G
W
T
Q
A
L
A
R
E
M
A
P
K
N
I
R
V
N
C
V
C
P
G
----
F
V
K
T
A
M
Q
E
R
E
I
I
W
E
A
E
L
R
G
M
T
P
E
---
A
V
R
A
E
-
Y
V
S
-----
L
T
P
L
G
R
I
E
E
P
E
D
V
A
D
V
V
V
F
L
A
S
D
A
A
R
F
M
T
G
Q
G
I
N
V
T
G
G
V
R
M
--
78
PsiBlast_CBE
73.16
31%
-12
- C1 -
2YZ7
2
?
C:
[2-256]
----
L
K
G
K
K
A
V
V
T
G
S
T
S
G
I
G
L
A
M
A
T
E
L
A
K
A
G
A
D
V
V
I
N
G
F
G
Q
P
E
D
I
E
---
R
E
R
S
T
L
E-
S
K
F
---
G
V
K-
A
Y
Y
L
N
--
A
D
L
S
D
A
Q
A
T
R
D
F
I
A
-
K
A
-
A
E
A
L
G
G
L
D
I
L
V
N
N
A
G
I
Q
H
T
--
A
P
I
E
E
F
P
V
D
K
W
N
A
I
I
A
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
I
M
Q
K
Q
-
G
W
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
V
-
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
T
A
L
E
N
A
G
K
G
I
T
C
N
A
I
C
P
G
----
W
V
R
T
P
L
V
E
K
Q
I
E
A
I
S
Q
Q
K
G
I
D
I
E
---
A
A
A
R
E
-
L
L
A
-
E
K
Q
P
S
---
L
Q
F
V
T
P
E
Q
L
G
G
A
A
V
F
L
S
S
A
A
A
D
Q
M
T
G
T
T
L
S
L
D
G
G
-----
4
PsiBlast_PDB
73.01
33%
-32
- C1 -
3AI3
3
?
A:
[1-263]
M
D
M
G
I
S
G
K
V
A
V
I
T
G
S
S
S
G
I
G
L
A
I
A
E
G
F
A
K
E
G
A
H
I
V
L
V
A
R
Q
V
-
D
R
L
H
E
A
A
R
S
L
K
E
K
--
F
G
V
---
R
V
--
L
E
-
V
A
--
V
D
V
A
T
P
E
G
V
D
A
V
V
E
-
S
V
R
S
S
-
F
G
G
A
D
I
L
V
N
N
A
G
T
G
S
N
--
E
T
I
M
E
A
A
D
E
K
W
Q
F
Y
W
E
L
L
V
M
A
A
V
R
L
A
R
G
L
V
P
G
M
R
A
R
-
G
G
G
A
I
I
H
N
A
S
I
C
A
V
Q
P
L
W
-
Y
E
P
I
Y
N
V
T
K
A
A
L
M
M
F
S
K
T
L
A
T
E
V
I
K
D
N
I
R
V
N
C
I
N
P
G
LILT
P
D
W
I
K
--------
T
A
K
E
L
T
K
D
N
G
---
G
D
W
K
G
-
Y
L
Q
S
V
A
D
E
H
A
P
I
K
R
F
A
S
P
E
E
L
A
N
F
F
V
F
L
C
S
E
R
A
T
Y
S
V
G
S
A
Y
F
V
D
G
G
M
L
K
T
L
54
PsiBlast_CBE
72.86
31%
-43
- C1 -
2Q2V
1
?
B:
[2-253]
----
L
K
G
K
T
A
L
V
T
G
S
T
S
G
I
G
L
G
I
A
Q
V
L
A
R
A
G
A
N
I
V
L
N
G
F
G
D
-
P
A
-----
P
A
L
A
E
I
--
A
R
H
---
G
V
K
A
V
H
H
P
A
DL
S
D
V
A
Q
I
E
A
L
F
A
L
A
E
-
R
---
E
-
F
G
G
V
D
I
L
V
N
N
A
G
I
Q
H
V
--
A
P
V
E
Q
F
P
L
E
S
W
D
K
I
I
A
L
N
L
S
A
V
F
H
G
T
R
L
A
L
P
G
M
R
A
R
-
N
W
G
R
I
I
N
I
A
S
V
H
G
L
V
G
S
T
-
G
K
A
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
V
G
L
E
T
A
T
S
N
V
T
C
N
A
I
C
P
G
----
W
V
L
T
P
L
V
Q
K
Q
I
D
D
R
A
-
A
--
G
D
P
L
---
Q
A
Q
H
D
-
L
L
A
-
E
K
Q
P
S
---
L
A
F
V
T
P
E
H
L
G
E
L
V
L
F
L
C
S
E
A
G
S
Q
V
R
G
A
A
W
N
V
D
G
G
W
L
---
30
PsiBlast_CBE
72.84
33%
-34
- C1 -
3AI3
3
?
C:
[1-263]
M
D
M
G
I
S
G
K
V
A
V
I
T
G
S
S
S
G
I
G
L
A
I
A
E
G
F
A
K
E
G
A
H
I
V
L
V
A
R
Q
V
-
D
R
L
H
EAA
R
S
L
K
E
K
--
F
G
V
---
R
V
--
L
E
-
V
A
--
V
D
V
A
T
P
E
G
V
D
A
V
V
E
-
S
V
R
S
S
-
F
G
G
A
D
I
L
V
N
N
A
G
T
G
S
N
--
E
T
I
M
E
A
A
D
E
K
W
Q
F
Y
W
E
L
L
V
M
A
A
V
R
L
A
R
G
L
V
P
G
M
R
A
R
-
G
G
G
A
I
I
H
N
A
S
I
C
A
V
Q
P
L
W
-
Y
E
P
I
Y
N
V
T
K
A
A
L
M
M
F
S
K
T
L
A
T
E
V
I
K
D
N
I
R
V
N
C
I
N
P
G
LILT
P
D
W
I
K
--------
T
A
K
E
L
T
K
D
N
G
---
G
D
W
K
G
-
Y
L
Q
S
V
A
D
E
H
A
P
I
K
R
F
A
S
P
E
E
L
A
N
F
F
V
F
L
C
S
E
R
A
T
Y
S
V
G
S
A
Y
F
V
D
G
G
M
L
K
T
L
28
PsiBlast_CBE
72.70
33%
-35
- C1 -
3AI3
5
?
G:
[1-263]
M
D
M
G
I
S
G
K
V
A
V
I
T
G
S
S
S
G
I
G
L
A
I
A
E
G
F
A
K
E
G
A
H
I
V
L
V
A
R
Q
V
-
D
R
L
H
EAA
R
S
L
K
E
K
--
F
G
V
---
R
V
--
L
E
-
V
A
--
V
D
V
A
T
P
E
G
V
D
A
V
V
E
-
S
V
R
S
S
-
F
G
G
A
D
I
L
V
N
N
A
G
T
G
S
N
--
E
T
I
M
E
A
A
D
E
K
W
Q
F
Y
W
E
L
L
V
M
A
A
V
R
L
A
R
G
L
V
P
G
M
R
A
R
-
G
G
G
A
I
I
H
N
A
S
I
C
A
V
Q
P
L
W
-
Y
E
P
I
Y
N
V
T
K
A
A
L
M
M
F
S
K
T
L
A
T
E
V
I
K
D
N
I
R
V
N
C
I
N
P
G
LILT
P
D
W
I
K
--------
T
A
K
E
L
T
K
D
N
G
---
G
D
W
K
G
-
Y
L
Q
S
V
A
D
E
H
A
P
I
K
R
F
A
S
P
E
E
L
A
N
F
F
V
F
L
C
S
E
R
A
T
Y
S
V
G
S
A
Y
F
V
D
G
G
M
L
K
T
L
22
PsiBlast_CBE
72.35
33%
-33
- C1 -
3AI2
1
?
G:
[1-263]
M
D
M
G
I
S
G
K
V
A
V
I
T
G
S
S
S
G
I
G
L
A
I
A
E
G
F
A
K
E
G
A
H
I
V
L
V
A
R
Q
V
-
D
R
L
H
EAA
R
S
L
K
E
K
--
F
G
V
---
R
V
--
L
E
-
V
A
--
V
D
V
A
T
P
E
G
V
D
A
V
V
E
-
S
V
R
S
S
-
F
G
G
A
D
I
L
V
N
N
A
G
T
G
S
N
--
E
T
I
M
E
A
A
D
E
K
W
Q
F
Y
W
E
L
H
V
M
A
A
V
R
L
A
R
G
L
V
P
G
M
R
A
R
-
G
G
G
A
I
I
H
N
A
S
I
C
A
V
Q
P
L
W
-
Y
E
P
I
Y
N
V
T
K
A
A
L
M
M
F
S
K
T
L
A
T
E
V
I
K
D
N
I
R
V
N
C
I
N
P
G
LILT
P
D
W
I
K
--------
T
A
K
E
L
T
K
D
N
G
---
G
D
W
K
G
-
Y
L
Q
S
V
A
D
E
H
A
P
I
K
R
F
A
S
P
E
E
L
A
N
F
F
V
F
L
C
S
E
R
A
T
Y
S
V
G
S
A
Y
F
V
D
G
G
M
L
K
T
L
3
PsiBlast_PDB
72.19
33%
-33
- C1 -
3AI2
1
?
A:
[1-263]
M
D
M
G
I
S
G
K
V
A
V
I
T
G
S
S
S
G
I
G
L
A
I
A
E
G
F
A
K
E
G
A
H
I
V
L
V
A
R
Q
V
-
D
R
L
H
E
A
A
R
S
L
K
E
K
--
F
G
V
---
R
V
--
L
E
-
V
A
--
V
D
V
A
T
P
E
G
V
D
A
V
V
E
-
S
V
R
S
S
-
F
G
G
A
D
I
L
V
N
N
A
G
T
G
S
N
--
E
T
I
M
E
A
A
D
E
K
W
Q
F
Y
W
E
L
H
V
M
A
A
V
R
L
A
R
G
L
V
P
G
M
R
A
R
-
G
G
G
A
I
I
H
N
A
S
I
C
A
V
Q
P
L
W
-
Y
E
P
I
Y
N
V
T
K
A
A
L
M
M
F
S
K
T
L
A
T
E
V
I
K
D
N
I
R
V
N
C
I
N
P
G
LILT
P
D
W
I
K
--------
T
A
K
E
L
T
K
D
N
G
---
G
D
W
K
G
-
Y
L
Q
S
V
A
D
E
H
A
P
I
K
R
F
A
S
P
E
E
L
A
N
F
F
V
F
L
C
S
E
R
A
T
Y
S
V
G
S
A
Y
F
V
D
G
G
M
L
K
T
L
53
PsiBlast_CBE
72.17
31%
-48
- C1 -
2Q2V
1
?
C:
[2-253]
----
L
K
G
K
T
A
L
V
T
G
S
T
S
G
I
G
L
G
I
A
Q
V
L
A
R
A
G
A
N
I
V
L
N
G
F
G
D
-
P
A
-----
P
A
L
A
E
I
--
A
R
H
---
G
V
KA
V
H
H
P
A
DL
S
D
V
A
Q
I
E
A
L
F
A
L
A
E
-
R
---
E
-
F
G
G
V
D
I
L
V
N
N
A
G
I
Q
H
V
--
A
P
V
E
Q
F
P
L
E
S
W
D
K
I
I
A
L
N
L
S
A
V
F
H
G
T
R
L
A
L
P
G
M
R
A
R
-
N
W
G
R
I
I
N
I
A
S
V
H
G
L
V
G
S
T
-
G
K
A
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
V
G
L
E
T
A
T
S
N
V
T
C
N
A
I
C
P
G
----
W
V
L
T
P
L
V
Q
K
Q
I
D
D
R
--------
L
---
Q
A
Q
H
D
-
L
L
A
-
E
K
Q
P
S
---
L
A
F
V
T
P
E
H
L
G
E
L
V
L
F
L
C
S
E
A
G
S
Q
V
R
G
A
A
W
N
V
D
G
G
W
L
---
26
PsiBlast_CBE
72.16
33%
-33
- C1 -
3AI2
1
?
C:
[1-263]
M
D
M
G
I
S
G
K
V
A
V
I
T
G
S
S
S
G
I
G
L
A
I
A
E
G
F
A
K
E
G
A
H
I
V
L
V
A
R
Q
V
-
D
R
L
H
EAA
R
S
L
K
E
K
--
F
G
V
---
R
V
--
L
E
-
V
A
--
V
D
V
A
T
P
E
G
V
D
A
V
V
E
-
S
V
R
S
S
-
F
G
G
A
D
I
L
V
N
N
A
G
T
G
S
N
--
E
T
I
M
E
A
A
D
E
K
W
Q
F
Y
W
E
L
H
V
M
A
A
V
R
L
A
R
G
L
V
P
G
M
R
A
R
-
G
G
G
A
I
I
H
N
A
S
I
C
A
V
Q
P
L
W
-
Y
E
P
I
Y
N
V
T
K
A
A
L
M
M
F
S
K
T
L
A
T
E
V
I
K
D
N
I
R
V
N
C
I
N
P
G
LILT
P
D
W
I
K
--------
T
A
K
E
L
T
K
D
N
G
---
G
D
W
K
G
-
Y
L
Q
S
V
A
D
E
H
A
P
I
K
R
F
A
S
P
E
E
L
A
N
F
F
V
F
L
C
S
E
R
A
T
Y
S
V
G
S
A
Y
F
V
D
G
G
M
L
K
T
L
25
PsiBlast_CBE
72.10
33%
-34
- C1 -
3AI2
1
?
D:
[1-263]
M
D
M
G
I
S
G
K
V
A
V
I
T
G
S
S
S
G
I
G
L
A
I
A
E
G
F
A
K
E
G
A
H
I
V
L
V
A
R
Q
V
-
D
R
L
H
EAA
R
S
L
K
E
K
--
F
G
V
---
R
V
--
L
E
-
V
A
--
V
D
V
A
T
P
E
G
V
D
A
V
V
E
-
S
V
R
S
S
-
F
G
G
A
D
I
L
V
N
N
A
G
T
G
S
N
--
E
T
I
M
E
A
A
D
E
K
W
Q
F
Y
W
E
L
H
V
M
A
A
V
R
L
A
R
G
L
V
P
G
M
R
A
R
-
G
G
G
A
I
I
H
N
A
S
I
C
A
V
Q
P
L
W
-
Y
E
P
I
Y
N
V
T
K
A
A
L
M
M
F
S
K
T
L
A
T
E
V
I
K
D
N
I
R
V
N
C
I
N
P
G
LILT
P
D
W
I
K
--------
T
A
K
E
L
T
K
D
N
G
---
G
D
W
K
G
-
Y
L
Q
S
V
A
D
E
H
A
P
I
K
R
F
A
S
P
E
E
L
A
N
F
F
V
F
L
C
S
E
R
A
T
Y
S
V
G
S
A
Y
F
V
D
G
G
M
L
K
T
L
61
PsiBlast_CBE
71.97
31%
-42
- C1 -
2Q2Q
1
?
A:
[2-253]
----
L
K
G
K
T
A
L
V
T
G
S
T
S
G
I
G
L
G
I
A
Q
V
L
A
R
A
G
A
N
I
V
L
N
G
F
G
D
-
P
A
-----
P
A
L
A
E
I
--
A
R
H
---
G
V
K
A
V
H
H
P
A
DL
S
D
V
A
Q
I
E
A
L
F
A
L
A
E
-
R
---
E
-
F
G
G
V
D
I
L
V
N
N
A
G
I
Q
H
V
--
A
P
V
E
Q
F
P
L
E
S
W
D
K
I
I
A
L
N
L
S
A
V
F
H
G
T
R
L
A
L
P
G
M
R
A
R
-
N
W
G
R
I
I
N
I
A
S
V
H
G
L
V
G
S
T
-
G
K
A
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
V
G
L
E
T
A
T
S
N
V
T
C
N
A
I
C
P
G
----
W
V
L
T
P
L
V
Q
K
Q
I
D
D
R
------
D
P
L
---
Q
A
Q
H
D
-
L
L
A
-
E
K
Q
P
S
---
L
A
F
V
T
P
E
H
L
G
E
L
V
L
F
L
C
S
E
A
G
S
Q
V
R
G
A
A
W
N
V
D
G
G
W
L
---
59
PsiBlast_CBE
71.92
31%
-41
- C1 -
2Q2Q
1
?
D:
[2-253]
----
L
K
G
K
T
A
L
V
T
G
S
T
S
G
I
G
L
G
I
A
Q
V
L
A
R
A
G
A
N
I
V
L
N
G
F
G
D
-
P
A
-----
P
A
L
A
E
I
--
A
R
H
---
G
V
K
A
V
H
H
P
A
DL
S
D
V
A
Q
I
E
A
L
F
A
L
A
E
-
R
---
E
-
F
G
G
V
D
I
L
V
N
N
A
G
I
Q
H
V
--
A
P
V
E
Q
F
P
L
E
S
W
D
K
I
I
A
L
N
L
S
A
V
F
H
G
T
R
L
A
L
P
G
M
R
A
R
-
N
W
G
R
I
I
N
I
A
S
V
H
G
L
V
G
S
T
-
G
K
A
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
V
G
L
E
T
A
T
S
N
V
T
C
N
A
I
C
P
G
----
W
V
L
T
P
L
V
Q
K
Q
I
D
D
R
A
-
A
N
G
G
D
P
L
---
Q
A
Q
H
D
-
L
L
A
-
E
K
Q
P
S
---
L
A
F
V
T
P
E
H
L
G
E
L
V
L
F
L
C
S
E
A
G
S
Q
V
R
G
A
A
W
N
V
D
G
G
W
L
---
29
PsiBlast_CBE
71.69
33%
-30
- C1 -
3AI3
4
?
E:
[1-263]
M
D
M
G
I
S
G
K
V
A
V
I
T
G
S
S
S
G
I
G
L
A
I
A
E
G
F
A
K
E
G
A
H
I
V
L
V
A
R
Q
V
-
D
R
L
H
EAA
R
S
L
K
E
K
--
F
G
V
---
R
V
--
L
E
-
V
A
--
V
D
V
A
T
P
E
G
V
D
A
V
V
E
-
S
V
R
S
S
-
F
G
G
A
D
I
L
V
N
N
A
G
T
G
S
N
--
E
T
I
M
E
A
A
D
E
K
W
Q
F
Y
W
E
L
L
V
M
A
A
V
R
L
A
R
G
L
V
P
G
M
R
A
R
-
G
G
G
A
I
I
H
N
A
S
I
C
A
V
Q
P
L
W
-
Y
E
P
I
Y
N
V
T
K
A
A
L
M
M
F
S
K
T
L
A
T
E
V
I
K
D
N
I
R
V
N
C
I
N
P
G
LILT
P
D
W
I
K
--------
T
A
K
E
L
T
K
D
N
G
---
G
D
W
K
G
-
Y
L
Q
S
V
A
D
E
H
A
P
I
K
R
F
A
S
P
E
E
L
A
N
F
F
V
F
L
C
S
E
R
A
T
Y
S
V
G
S
A
Y
F
V
D
G
G
M
L
K
T
L
64
PsiBlast_CBE
71.58
31%
-21
- C1 -
3W8D
6
?
A:
[2-256]
----
L
K
G
K
K
A
V
V
T
G
S
T
S
G
I
G
L
A
M
A
T
E
L
A
K
A
G
A
D
V
V
I
N
G
F
G
Q
P
E
D
I
E
---
R
E
R
S
T
L
E
-
S
K
F
---
G
V
K
-
A
Y
Y
L
N
--
A
D
L
S
D
A
Q
A
T
R
D
F
I
A
-
K
A
-
A
E
A
L
G
G
L
D
I
L
V
N
N
A
G
I
Q
H
T
--
A
P
I
E
E
F
P
V
D
K
W
N
A
I
I
A
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
I
M
Q
K
Q
-
G
W
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
V
-
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
T
A
L
E
N
A
G
K
G
I
T
C
N
A
I
C
P
G
----
W
V
R
T
P
L
V
E
K
Q
I
E
A
I
S
Q
Q
K
G
I
D
I
E
---
A
A
A
R
E
-
L
L
A
-
E
K
Q
P
S
---
L
Q
F
V
T
P
E
Q
L
G
G
A
A
V
F
L
S
S
A
A
A
D
Q
M
T
G
T
T
L
S
L
D
G
G
-----
24
PsiBlast_CBE
71.56
33%
-32
- C1 -
3AI2
1
?
E:
[1-263]
M
D
M
G
I
S
G
K
V
A
V
I
T
G
S
S
S
G
I
G
L
A
I
A
E
G
F
A
K
E
G
A
H
I
V
L
V
A
R
Q
V
-
D
R
L
H
EAA
R
S
L
K
E
K
--
F
G
V
---
R
V
--
L
E
-
V
A
--
V
D
V
A
T
P
E
G
V
D
A
V
V
E
-
S
V
R
S
S
-
F
G
G
A
D
I
L
V
N
N
A
G
T
G
S
N
--
E
T
I
M
E
A
A
D
E
K
W
Q
F
Y
W
E
L
H
V
M
A
A
V
R
L
A
R
G
L
V
P
G
M
R
A
R
-
G
G
G
A
I
I
H
N
A
S
I
C
A
V
Q
P
L
W
-
Y
E
P
I
Y
N
V
T
K
A
A
L
M
M
F
S
K
T
L
A
T
E
V
I
K
D
N
I
R
V
N
C
I
N
P
G
LILT
P
D
W
I
K
--------
T
A
K
E
L
T
K
D
N
G
---
G
D
W
K
G
-
Y
L
Q
S
V
A
D
E
H
A
P
I
K
R
F
A
S
P
E
E
L
A
N
F
F
V
F
L
C
S
E
R
A
T
Y
S
V
G
S
A
Y
F
V
D
G
G
M
L
K
T
L
2
PsiBlast_PDB
71.53
33%
-32
- C1 -
3AI1
-
?
A:
[1-263]
M
D
M
G
I
S
G
K
V
A
V
I
T
G
S
S
S
G
I
G
L
A
I
A
E
G
F
A
K
E
G
A
H
I
V
L
V
A
R
Q
V
-
D
R
L
H
E
A
A
R
S
L
K
E
K
--
F
G
V
---
R
V
--
L
E
-
V
A
--
V
D
V
A
T
P
E
G
V
D
A
V
V
E
-
S
V
R
S
S
-
F
G
G
A
D
I
L
V
N
N
A
G
T
G
S
N
--
E
T
I
M
E
A
A
D
E
K
W
Q
F
Y
W
E
L
H
V
M
A
A
V
R
L
A
R
G
L
V
P
G
M
R
A
R
-
G
G
G
A
I
I
H
N
A
S
I
C
A
V
Q
P
L
W
-
Y
E
P
I
Y
N
V
T
K
A
A
L
M
M
F
S
K
T
L
A
T
E
V
I
K
D
N
I
R
V
N
C
I
N
P
G
LILT
P
D
W
I
K
--------
T
A
K
E
L
T
K
D
N
G
---
G
D
W
K
G
-
Y
L
Q
S
V
A
D
E
H
A
P
I
K
R
F
A
S
P
E
E
L
A
N
F
F
V
F
L
C
S
E
R
A
T
Y
S
V
G
S
A
Y
F
V
D
G
G
M
L
K
T
L
70
PsiBlast_CBE
71.51
31%
-16
- C1 -
3VDQ
4
?
C:
[2-256]
----
L
K
G
K
K
A
V
V
T
G
S
T
S
G
I
G
L
A
M
A
T
E
L
A
K
A
G
A
D
V
V
I
N
G
F
G
Q
P
E
D
I
E
---
R
E
R
S
T
L
E-
S
K
F
---
G
V
K-
A
Y
Y
L
N
--
A
D
L
S
D
A
Q
A
T
R
D
F
I
A
-
K
A
-
A
E
A
L
G
G
L
D
I
L
V
N
N
A
G
I
Q
H
T
--
A
P
I
E
E
F
P
V
D
K
W
N
A
I
I
A
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
I
M
Q
K
Q
-
G
W
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
V
-
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
T
A
L
E
N
A
G
K
G
I
T
C
N
A
I
C
P
G
----
W
V
R
T
P
L
V
E
K
Q
I
E
A
I
S
Q
Q
K
G
I
D
I
E
---
A
A
A
R
E
-
L
L
A
-
E
K
Q
P
S
---
L
Q
F
V
T
P
E
Q
L
G
G
A
A
V
F
L
S
S
A
A
A
D
Q
M
T
G
T
T
L
S
L
D
G
G
-----
120
HHSearch
66.93
33%
-26
- C1 -
4H15
18
?
A:
[7-260]
--
L
N
L
R
G
K
R
A
L
I
T
A
G
T
K
G
A
G
A
A
T
V
S
L
F
L
E
L
G
A
Q
V
L
T
T
A
R
A
R
-
P
E
G
L
-----------------
P
E
--
E
L
F
V
E
--
A
D
L
T
T
K
E
G
C
A
I
V
A
E
A
T
R
-
Q
R
-
L
G
G
V
D
V
I
V
H
M
L
G
G
S
S
A
AG
G
G
F
S
A
L
S
D
D
D
W
Y
N
E
L
S
L
N
L
F
A
A
V
R
L
D
R
Q
L
V
P
D
M
V
A
R
-
G
S
G
V
V
V
H
V
T
S
I
Q
R
V
L
P
L
P
E
S
T
T
A
Y
A
A
A
K
A
A
L
S
T
Y
S
K
A
M
S
K
E
V
S
P
K
G
V
R
V
V
R
V
S
P
G
----
W
I
E
T
E
A
S
V
R
L
A
E
R
L
A
K
Q
A
G
T
D
L
E
G
G
K
K
I
I
M
D
-
G
L
G
-----
G
I
P
L
G
R
P
A
K
P
E
E
V
A
N
L
I
A
F
L
A
S
D
R
A
A
S
I
T
G
A
E
Y
T
I
D
G
G
T
V
P
T
-