@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu33430: (2016-07-26 )
MVTKILKAPDGSPSDVERIKKESDYLRGTLKEVMLDRISAGIPDDDNRLMKHHGSYLQDDRDLRNERQKQKLEPAYQFMLRVRMPGGVSTPEQWLVMDDLSQKYGNGTLKLTTRETFQMHGILKWNMKKTIQTIHSALLDTIAACGDVNRNVMCASNPYQSEIHSEVYEWSKKLSDDLLPRTRAYHEIWLDEERVAGTPEEEVEPMYGPLYLPRKFKIGIAVPPSNDIDVFSQDLGFIAIVEDGKLIGFNVAIGGGMGMTHGDTATYPQLAKVIGFCRPEQMYDVAEKTITIQRDYGNRSVRKNARFKYTVDRLGLENVKEELENRLGWSLEEAKPYHFDHNGDRYGWVEGIEDKWHFTLFVEGGRITDYDDYKLMTGLREIAKVHTGEFRLTANQNLMIANVSSDKKEEISALIEQYGLTDGKHYSALRRSSMACVALPTCGLAMAEAERYLPTLLDKIEEIIDENGLRDQEITIRMTGCPNGCARHALGEIGFIGKAPGKYNMYLGAAFDGSRLSKMYRENIGEADILSELRILLSRYAKEREEGEHFGDFVIRAGIIKATTDGTNFHD
Atome Classification :
(21 SA)
-.........10........20..--......--30--.........40..-----...-.-..50........60....---....70....---....80........90........100...-.-.-...110.......120.......130.......140.......150.......160.-......170.......180-.........190....---...200.......210.......220......--.230.--......240.......250.......260.......270..-.-..-..-280.......290.......300.......310.......320....-...------330.-..-...--.--..340.----......350........-360.-......370.......380-....-.-..390.......400.......410-......-..420........430.......440......----.450........460......-.470........480.......490.....---.--------.500------..--------.----......--510-..-......520........530....-.----..540.......550.......560....-..-.570
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MV
T
K
ILKAPDG
S
P
S
D
V
E
R
I
K
K
E
S
--
D
Y
L
R
G
T
--
L
---
K
E
V
M
L
D
R
I
SAGIP-----DDD-
N
-
R
L
M
K
HHG
S
Y
LQ
D
D
R
D
L
R
N
---
E
R
Q
K
Q
KL
E
P
A
---
Y
Q
F
M
L
R
V
RMPGGVST
P
E
Q
W
L
V
M
D
D
L
S
-
Q
K
Y-G-N-
G
T
L
K
L
T
T
R
E
T
F
Q
MH
G
I
L
K
W
N
M
K
K
T
I
Q
T
I
H
S
A
L
L
D
T
I
A
A
CGDVNR
N
V
M
CASNP
Y
Q
S
E
I
-
H
S
E
V
Y
E
W
S
K
K
L
S
D
D
LLP---
R
T
R
A
Y
H
E
IWLD
E
E
RVA---GT
P
E
EEVEPMYGPLYLP
R
K
F
K
I
G
I
AVPPSN
D
I
--
D
V
F
SQ--DL
G
F
I
A
I
VEDG
K
L
I
G
F
N
V
A
IGGGMGMTHGDTA
T
Y
P
Q
L
A
K
V
I-G-FC-
R
P
-
E
Q
M
Y
D
V
A
E
K
T
I
T
I
Q
RDYGNRSVRKNA
R
F
K
Y
T
V
D
RL
G
L
E
N
V
K
E
E
L
E
N
R-LGW------S--L-EE-AKP--Y--HFDHNG----DRYGWVEG-IEDK
W
H
F
T
-
L
F
VE-GGRITDYD
D
Y
K
L
M
T
G
L
R
E
I
-
A
K
VH-T-G
E
F
R
L
TANQ
N
L
M
I
A
NVSSD
K
K
E
E
I
--
S
A
L
I
E
Q-YGL-TDG
K
H
Y
S
A
L
R
RSS
M
A
C
V
ALPTC
G
L
A
M
A
E
----
A
E
-
R
Y
L
P
T
L
L
D
K
I
E
E
I
I
D
ENG-LR-D
Q
E
I
T
I
R
M
TGCP
N
G
C
A
R
H
A
L
GEIGFIG---K--------AP--------GK--------Y----
N
M
Y
L
G
A--AF--
D
G
-
S
R
L
S
K
M
Y
R
-
E
NIG
E
A
D
I
L
S
E
L
R
I
L
-
L
----
S
R
Y
A
K
E
R
EEG
E
H
F
G
D
F
V
I
RA
G
I
I
K
ATTDG-TN-FHD
2
PsiBlast_PDB
78.98
51%
0
- C3 -
4G39
5
CYSI_ECOLI
A:
[80-563]
--------------------------------------------------------------------------------------------------
M
L
L
R
C
R
L
P
G
G
V
I
T
T
K
Q
W
Q
A
I
D
K
F
A
G
E
N
T
-
I
-
Y
-
G
S
I
R
L
T
N
R
Q
T
F
Q
F
H
G
I
L
K
K
N
V
K
P
V
H
Q
M
L
H
S
V
G
L
D
A
L
A
T
A
N
D
M
N
S
N
V
L
C
T
S
N
P
Y
E
S
Q
L
-
H
A
E
A
Y
E
W
A
K
K
I
S
E
H
L
L
P
-----------------------------------
T
Y
L
P
R
K
F
K
T
T
V
V
I
P
P
Q
N
D
I
--
D
L
H
A
N
--
D
M
N
F
V
A
I
A
E
N
G
K
L
V
G
F
N
L
L
V
G
G
G
L
S
I
E
H
G
N
K
K
T
Y
A
R
T
A
S
E
F
-
G
-
Y
L
-
P
L
-
E
H
T
L
A
V
A
E
A
V
V
T
T
Q
R
D
W
G
N
R
T
D
R
K
N
A
K
T
K
Y
T
L
E
R
V
G
V
E
T
F
K
A
E
V
E
R
R
-
A
G
I
------
K
--
F
-
E
P
-
I
R
P
--
Y
--
E
F
T
G
R
G
----
D
R
I
G
W
V
K
G
-
I
D
D
N
W
H
L
T
-
L
F
I
E
-
N
G
R
I
L
D
Y
P
A
R
P
L
K
T
G
L
L
E
I
-
A
K
I
H
-
K
-
G
D
F
R
I
T
A
N
Q
N
L
I
I
A
G
V
P
E
S
E
K
A
K
I
--
E
K
I
A
K
E
-
S
G
L
-
M
N
A
--
V
T
P
Q
R
E
N
S
M
A
C
V
S
F
P
T
C
P
L
A
M
A
E
----
A
E
-
R
F
L
P
S
F
I
D
N
I
D
N
L
M
A
K
H
G
-
V
S
-
D
E
H
I
V
M
R
V
T
G
C
P
N
G
C
G
R
A
M
L
A
E
V
G
L
V
G
---
K
--------
A
P
--------
G
R
--------
Y
----
N
L
H
L
G
G
--
N
R
--
I
G
-
T
R
I
P
R
M
Y
K
-
E
N
I
T
E
P
E
I
L
A
S
L
D
E
L
-
I
----
G
R
W
A
K
E
R
E
A
G
E
G
F
G
D
F
T
V
R
A
G
I
I
R
P
V
L
D
--------
4
PsiBlast_PDB
78.93
51%
4
- C3 -
2GEP
4
CYSI_ECOLI
A:
[8-490]
---------------------------------------------------------------------------------------------------
L
L
R
C
R
L
P
G
G
V
I
T
T
K
Q
W
Q
A
I
D
K
F
A
G
E
N
T
-
I
-
Y
-
G
S
I
R
L
T
N
R
Q
T
F
Q
F
H
G
I
L
K
K
N
V
K
P
V
H
Q
M
L
H
S
V
G
L
D
A
L
A
T
A
N
D
M
N
R
N
V
L
C
T
S
N
P
Y
E
S
Q
L
-
H
A
E
A
Y
E
W
A
K
K
I
S
E
H
L
L
P
---
R
T
---------------------
E
---
P
I
L
G
Q
T
Y
L
P
R
K
F
K
T
T
V
V
I
P
P
Q
N
D
I
--
D
L
H
A
N
--
D
M
N
F
V
A
I
A
E
N
G
K
L
V
G
F
N
L
L
V
G
G
G
L
S
I
E
H
G
N
K
K
T
Y
A
R
T
A
S
E
F
-
G
-
Y
L
-
P
L
-
E
H
T
L
A
V
A
E
A
V
V
T
T
Q
R
D
W
G
N
R
T
D
R
K
N
A
K
T
K
Y
T
L
E
R
V
G
V
E
T
F
K
A
E
V
E
R
R
-
A
G
I
------
K
--
F
-
E
P
-
I
R
P
--
Y
--
E
F
T
G
R
G
----
D
R
I
G
W
V
K
G
-
I
D
D
N
W
H
L
T
-
L
F
I
E
-
N
G
R
I
L
D
Y
P
A
R
P
L
K
T
G
L
L
E
I
-
A
K
I
H
-
K
-
G
D
F
R
I
T
A
N
Q
N
L
I
I
A
G
V
P
E
S
E
K
A
K
I
--
E
K
I
A
K
E
-
S
G
L
-
M
N
A
--
V
T
P
Q
R
E
N
S
M
A
C
V
S
F
P
T
C
P
L
A
M
A
E
----
A
E
-
R
F
L
P
S
F
I
D
N
I
D
N
L
M
A
K
H
G
-
V
S
-
D
E
H
I
V
M
R
V
T
G
C
P
N
G
C
G
R
A
M
L
A
E
V
G
L
V
G
---
K
--------
A
P
--------
G
R
--------
Y
----
N
L
H
L
G
G
--
N
R
--
I
G
-
T
R
I
P
R
M
Y
K
-
E
N
I
T
E
P
E
I
L
A
S
L
D
E
L
-
I
----
G
R
W
A
K
E
R
E
A
G
E
G
F
G
D
F
T
V
R
A
G
I
I
R
P
V
L
D
--------
5
PsiBlast_PDB
77.60
51%
3
- C3 -
3GEO
4
CYSI_ECOLI
A:
[8-490]
---------------------------------------------------------------------------------------------------
L
L
R
C
R
L
P
G
G
V
I
T
T
K
Q
W
Q
A
I
D
K
F
A
G
E
N
T
-
I
-
Y
-
G
S
I
R
L
T
N
R
Q
T
F
Q
F
H
G
I
L
-----
P
V
H
Q
M
L
H
S
V
G
L
D
A
L
----
D
M
N
R
N
V
L
C
T
S
N
P
Y
E
S
Q
L
-
H
A
E
A
Y
E
W
A
K
K
I
S
E
H
L
L
P
-----------------------------------
T
Y
L
P
R
K
F
K
T
T
V
V
I
P
P
Q
N
D
I
--
D
L
H
A
N
--
D
M
N
F
V
A
I
A
E
N
G
K
L
V
G
F
N
L
L
V
G
G
G
L
S
I
E
H
G
N
K
K
T
Y
A
R
T
A
S
E
F
-
G
-
Y
L
-
P
L
-
E
H
T
L
A
V
A
E
A
V
V
T
T
Q
R
D
W
G
N
R
T
D
R
K
N
A
K
T
K
Y
T
L
E
R
V
G
V
E
T
F
K
A
E
V
E
R
R
-
A
G
I
------
K
--
F
-
E
P
-
I
R
P
--
Y
--
E
F
T
G
R
G
----
D
R
I
G
W
V
K
G
-
I
D
D
N
W
H
L
T
-
L
F
I
E
-
N
G
R
I
L
D
Y
P
A
R
P
L
K
T
G
L
L
E
I
-
A
K
I
H
-
K
-
G
D
F
R
I
T
A
N
Q
N
L
I
I
A
G
V
P
E
S
E
K
A
K
I
--
E
K
I
A
K
E
-
S
G
L
-
M
N
A
--
V
T
P
Q
R
E
N
S
M
A
C
V
S
F
P
T
C
P
L
A
M
A
E
----
A
E
-
R
F
L
P
S
F
I
D
N
I
D
N
L
M
A
K
H
G
-
V
S
-
D
E
H
I
V
M
R
V
T
G
C
P
N
G
C
G
R
A
M
L
A
E
V
G
L
V
G
---
K
--------
A
P
--------
G
R
--------
Y
----
N
L
H
L
G
G
--
N
R
--
I
G
-
T
R
I
P
R
M
Y
K
-
E
N
I
T
E
P
E
I
L
A
S
L
D
E
L
-
I
----
G
R
W
A
K
E
R
E
A
G
E
G
F
G
D
F
T
V
R
A
G
I
I
R
P
V
L
D
--------
3
PsiBlast_PDB
77.07
52%
4
- C3 -
4HTR
4
CYSI_ECOLI
A:
[20-500]
-----------------------------------------------------------------------------------------------------
R
C
R
L
P
G
G
V
I
T
T
K
Q
W
Q
A
I
D
K
F
A
G
E
N
T
-
I
-
Y
-
G
S
I
R
L
T
N
R
Q
T
F
Q
F
H
G
I
L
-----
P
V
H
Q
M
L
H
S
V
G
L
D
A
------
M
N
R
N
V
L
C
T
S
N
P
Y
E
S
Q
L
-
H
A
E
A
Y
E
W
A
K
K
I
S
E
H
L
L
P
----------------------------------------
K
F
K
T
T
V
V
I
P
P
Q
N
D
I
--
D
L
H
A
N
--
D
M
N
F
V
A
I
A
E
N
G
K
L
V
G
F
N
L
L
V
G
G
G
L
S
I
E
H
G
N
K
K
T
Y
A
R
T
A
S
E
F
-
G
-
Y
L
-
P
L
-
E
H
T
L
A
V
A
E
A
V
V
T
T
Q
R
D
W
G
N
-----
N
A
K
T
K
Y
T
L
E
R
V
G
V
E
T
F
K
A
E
V
E
R
R
-
A
G
I
------
K
--
F
-
E
P
-
I
R
P
--
Y
--
E
F
T
G
R
G
----
D
R
I
G
W
V
K
G
-
I
D
D
N
W
H
L
T
-
L
F
I
E
-
N
G
R
I
L
D
Y
P
A
R
P
L
K
T
G
L
L
E
I
-
A
K
I
H
-
K
-
G
D
F
R
I
T
A
N
Q
N
L
I
I
A
G
V
P
E
S
E
K
A
K
I
--
E
K
I
A
K
E
-
S
G
L
-
M
N
A
--
V
T
P
Q
R
E
N
S
M
A
C
V
S
F
P
T
C
P
L
A
M
A
E
----
A
E
-
R
F
L
P
S
F
I
D
N
I
D
N
L
M
A
K
H
G
-
V
S
-
D
E
H
I
V
M
R
V
T
G
C
P
N
G
C
G
R
A
M
L
A
E
V
G
L
V
G
---
K
--------
A
P
--------
G
R
--------
Y
----
N
L
H
L
G
G
--
N
R
--
I
G
-
T
R
I
P
R
M
Y
K
-
E
N
I
T
E
P
E
I
L
A
S
L
D
E
L
-
I
----
G
R
W
A
K
E
R
E
A
G
E
G
F
G
D
F
T
V
R
A
G
I
I
R
P
V
L
D
--------
1
PsiBlast_PDB
77.02
51%
1
- C3 -
4G38
4
CYSI_ECOLI
A:
[81-563]
---------------------------------------------------------------------------------------------------
L
L
R
C
R
L
P
G
G
V
I
T
T
K
Q
W
Q
A
I
D
K
F
A
G
E
N
T
-
I
-
Y
-
G
S
I
R
L
T
N
R
Q
T
F
Q
F
H
G
I
L
-----
P
V
H
Q
M
L
H
S
V
G
L
D
A
L
A
T
A
W
D
M
N
R
N
V
L
C
T
S
N
P
Y
E
S
Q
L
-
H
A
E
A
Y
E
W
A
K
K
I
S
E
H
L
L
P
----------------------------------------
K
F
K
T
T
V
V
I
P
P
Q
N
D
I
--
D
L
H
A
N
--
D
M
N
F
V
A
I
A
E
N
G
K
L
V
G
F
N
L
L
V
G
G
G
L
S
I
E
H
G
N
K
K
T
Y
A
R
T
A
S
E
F
-
G
-
Y
L
-
P
L
-
E
H
T
L
A
V
A
E
A
V
V
T
T
Q
R
D
W
G
N
-----
N
A
K
T
K
Y
T
L
E
R
V
G
V
E
T
F
K
A
E
V
E
R
R
-
A
G
I
------
K
--
F
-
E
P
-
I
R
P
--
Y
--
E
F
T
G
R
G
----
D
R
I
G
W
V
K
G
-
I
D
D
N
W
H
L
T
-
L
F
I
E
-
N
G
R
I
L
D
Y
P
A
R
P
L
K
T
G
L
L
E
I
-
A
K
I
H
-
K
-
G
D
F
R
I
T
A
N
Q
N
L
I
I
A
G
V
P
E
S
E
K
A
K
I
--
E
K
I
A
K
E
-
S
G
L
-
M
N
A
--
V
T
P
Q
R
E
N
S
M
A
C
V
S
F
P
T
C
P
L
A
M
A
E
----
A
E
-
R
F
L
P
S
F
I
D
N
I
D
N
L
M
A
K
H
G
-
V
S
-
D
E
H
I
V
M
R
V
T
G
C
P
N
G
C
G
R
A
M
L
A
E
V
G
L
V
G
---
K
--------
A
P
--------
G
R
--------
Y
----
N
L
H
L
G
G
--
N
R
--
I
G
-
T
R
I
P
R
M
Y
K
-
E
N
I
T
E
P
E
I
L
A
S
L
D
E
L
-
I
----
G
R
W
A
K
E
R
E
A
G
E
G
F
G
D
F
T
V
R
A
G
I
I
R
P
V
L
D
--------
31
HHSearch
75.18
51%
13
- C3 -
4G38
4
CYSI_ECOLI
A:
[81-570]
---------------------------------------------------------------------------------------------------
L
L
R
C
R
L
P
G
G
V
I
T
T
K
Q
W
Q
A
I
D
K
F
A
-
G
E
N
-
T
I
Y
-
G
S
I
R
L
T
N
R
Q
T
F
Q
F
H
G
I
L
-----
P
V
H
Q
M
L
H
S
V
G
L
D
A
L
A
T
A
W
D
M
N
R
N
V
L
C
T
S
N
P
-
Y
E
S
Q
L
H
A
E
A
Y
E
W
A
K
K
I
S
E
H
L
L
P
----------------------------------------
K
F
K
T
T
V
V
I
P
P
Q
N
D
I
--
D
L
H
A
N
--
D
M
N
F
V
A
I
A
E
N
G
K
L
V
G
F
N
L
L
V
G
G
G
L
S
I
E
H
G
N
K
K
T
Y
A
R
T
A
S
E
F
-
G
-
Y
L
-
P
L
-
E
H
T
L
A
V
A
E
A
V
V
T
T
Q
R
D
W
G
N
-----
N
A
K
T
K
Y
T
L
E
R
V
G
V
E
T
F
K
A
E
V
E
R
R
-
A
G
I
------
K
--
F
-
E
P
-
I
R
P
--
Y
--
E
F
T
G
R
G
----
D
R
I
G
W
V
K
G
-
I
D
D
N
W
H
L
T
-
L
F
I
E
-
N
G
R
I
L
D
Y
P
A
R
P
L
K
T
G
L
L
E
I
-
A
K
I
H
-
K
-
G
D
F
R
I
T
A
N
Q
N
L
I
I
A
G
V
P
E
S
E
K
A
K
I
--
E
K
I
A
K
E
-
S
G
L
-
M
N
--
A
V
T
P
Q
R
E
N
S
M
A
C
V
S
F
P
T
C
P
L
A
M
A
E
----
A
E
-
R
F
L
P
S
F
I
D
N
I
D
N
L
M
A
K
H
G
-
V
S
-
D
E
H
I
V
M
R
V
T
G
C
P
N
G
C
G
R
A
M
L
A
E
V
G
L
V
G
---
K
--------
A
P
--------
G
R
--------
Y
----
N
L
H
L
G
G
--
N
R
--
I
G
-
T
R
I
P
R
M
Y
K
-
E
N
I
T
E
P
E
I
L
A
S
L
D
E
L
-
I
----
G
R
W
A
K
E
R
E
A
G
E
G
F
G
D
F
T
V
R
A
G
I
I
R
P
V
L
D
P
A
R
D
-
L
W
D
21
Fugue
57.10
24%
27
- C3 -
1ZJ8
3
SIR_MYCTU
A:
[21-566]
R
N
E
G
Q
W
A
L
G
H
R
E
P
L
N
A
N
E
E
L
K
K
A
G
NP
L
D
V
R
E
R
--
I
---
E
N
I
Y
A
K
Q
G
F
D
S
I
D
-----
K
T
D
-
L
R
G
R
F
R
W
W
G
L
Y
T
Q
R
E
Q
G
Y
D
G
---
T
W
T
G
D
D
N
I
D
K
LEA
K
Y
F
M
M
R
V
R
C
D
G
G
A
L
S
A
A
A
L
R
T
L
G
Q
I
S
-
T
E
F
-
A
-
R
-
D
T
A
D
I
S
D
R
Q
N
V
Q
Y
H
W
I
E
V
E
N
V
P
E
I
W
R
R
L
D
D
V
G
L
Q
T
T
E
A
C
G
D
C
P
R
V
V
L
G
S
P
--------------
L
A
G
E
S
L
D
E
V
L
D
---
P
T
W
A
I
E
E
I
V
R
R
Y
I
G
K
P
---
D
F
A
-----------
D
L
P
R
K
Y
K
T
A
I
S
--
G
L
Q
D
V
--
A
H
E
I
N
--
D
V
A
F
I
G
V
N
H
P
E
H
G
P
G
L
D
L
W
V
G
G
G
L
S
-------
T
N
P
M
L
A
Q
R
V
-
G
-
A
W
V
P
L
-
G
E
V
P
E
V
W
A
A
V
T
S
V
F
R
D
Y
G
Y
R
R
L
R
A
K
A
R
L
K
F
L
I
K
D
W
G
I
A
K
F
R
E
V
L
E
T
E
-
Y
L
K
------
R
P
L
I
-
D
G
-
P
A
P
--
E
--
P
V
K
H
P
I
----
D
H
V
G
V
Q
R
L
-
K
N
G
L
N
A
V
G
-
V
A
P
I
-
A
G
R
V
S
---
G
T
I
L
T
A
V
A
D
L
M
-
A
R
A
G
-
S
-
D
R
I
R
F
T
P
Y
Q
K
L
V
I
L
D
I
P
D
A
L
L
D
D
L
--
I
A
G
L
D
A
-
L
G
L
-
Q
S
R
--
P
S
H
W
R
R
N
L
M
A
C
S
G
I
E
F
C
K
L
S
F
A
E
----
T
R
-
V
R
A
Q
H
L
V
P
E
L
E
R
R
L
E
D
I
N
-
S
Q
L
D
V
P
I
T
V
N
I
N
G
C
P
N
S
C
A
R
I
Q
I
A
D
I
G
F
K
G
---
Q
--------
M
I
--------
D
D
GHG
G
S
V
E
G
F
----
Q
V
H
L
G
G
--
H
L
GL
D
A
-
G
F
G
R
K
L
R
Q
-
H
K
V
T
S
D
E
L
G
D
Y
I
D
R
V
-
V
----
R
N
F
V
K
H
R
S
E
G
E
R
F
A
Q
W
V
I
R
A
E
E
D
D
L
R
----------
32
HHSearch
56.83
23%
22
- C3 -
1ZJ8
3
SIR_MYCTU
A:
[32-565]
-----------
E
P
L
N
A
N
E
E
L
K
K
A
G
--
N
P
L
D
V
R
E
R
I
---
E
N
I
Y
A
K
Q
G
F
D
S
I
D
-----
K
T
D
L
R
-
G
R
F
R
W
W
G
L
Y
T
Q
R
E
Q
G
Y
D
G
TWT
G
D
D
N
I
D
K
L
E
A
---
K
Y
F
M
M
R
V
R
C
D
G
G
A
L
S
A
A
A
L
R
T
L
G
Q
I
S
-
T
E
F
-
A
-
R
-
D
T
A
D
I
S
D
R
Q
N
V
Q
Y
H
W
I
E
V
E
N
V
P
E
I
W
R
R
L
D
D
V
G
L
Q
T
T
E
A
C
G
D
C
P
R
V
V
L
G
S
P
L
A
G
E
S
L
D
E
V
L
D
P
T
W
A
I
E
E
I
V
R
R
Y
I
G
----
K
P
D
F
---------------------------
A
D
L
P
R
K
Y
K
T
A
I
S
G
L
Q
D
--
V
--
A
H
E
I
N
--
D
V
A
F
I
G
V
N
H
P
E
H
G
P
G
L
D
L
W
V
G
G
G
L
S
T
N
-------
P
M
L
A
Q
R
V
G
A
-
W
V
-
P
L
-
G
E
V
P
E
V
W
A
A
V
T
S
V
F
R
D
Y
G
Y
R
R
L
R
A
K
A
R
L
K
F
L
I
K
D
W
G
I
A
K
F
R
E
V
L
E
T
E
Y
L
K
R
------
P
--
L
-
I
D
G
P
A
P
--
E
--
P
V
K
H
P
I
----
D
H
V
G
V
Q
R
L
-
K
N
G
L
N
A
V
G
-
V
A
P
I
-
A
G
R
V
S
G
----
T
I
L
T
A
V
A
D
L
-
M
A
R
A
-
G
S
D
R
I
R
F
T
P
Y
Q
K
L
V
I
L
D
I
P
D
A
L
L
D
D
L
--
I
A
G
L
D
A
-
L
G
L
-
Q
S
--
R
P
S
H
W
R
R
N
L
M
A
C
S
G
I
E
F
C
K
L
S
F
A
E
----
T
R
-
V
R
A
Q
H
L
V
P
E
L
E
R
R
L
E
D
I
N
S
Q
L
-
D
V
P
I
T
V
N
I
N
G
C
P
N
S
C
A
R
I
Q
I
A
D
I
G
F
K
G
---
Q
--------
M
I
D
D
GHG
G
S
V
E
G
--------
F
----
Q
V
H
L
G
G
--
H
L
--
G
L
D
A
G
F
G
R
K
L
R
Q
H
K
V
T
S
D
E
L
G
D
Y
I
D
R
V
-
V
----
R
N
F
V
K
H
R
S
E
G
E
R
F
A
Q
W
V
I
R
A
E
E
D
D
L
-----------
7
PsiBlast_PDB
56.47
26%
3
- C3 -
1ZJ9
3
SIR_MYCTU
A:
[99-560]
----------------------------------------------------------------------------------------
K
L
E
A
K
---
Y
-
F
M
M
R
V
R
C
D
G
G
A
L
S
A
A
A
L
R
T
L
G
Q
I
S
-
T
E
F
-
A
-
R
-
D
T
A
D
I
S
D
R
Q
N
V
Q
Y
H
W
I
E
V
E
N
V
P
E
I
W
R
R
L
D
D
V
G
L
Q
T
T
E
A
C
G
D
C
P
R
V
V
L
--
G
S
P
L
A
G
E
S
-
L
D
E
V
-----------
L
D
---
P
T
W
A
I
E
E
I
---
V
R
R
Y
I
---
G
K
P
D
F
A
--------
D
L
P
R
K
Y
K
--
T
A
I
S
G
L
Q
D
V
--
A
H
E
I
N
--
D
V
A
F
I
G
V
N
H
P
E
H
G
P
G
L
D
L
W
V
G
G
G
L
-------
S
T
N
P
M
L
A
Q
R
V
-
G
-
A
W
-
V
P
L
G
E
V
P
E
V
W
A
A
V
T
S
V
F
R
D
Y
G
Y
R
R
L
R
A
K
A
R
L
K
F
L
I
K
D
W
G
I
A
K
F
R
E
V
L
E
T
E
-
Y
L
K
------
R
PL
I
-
D
G
-
P
A
P
--
E
--
P
V
K
H
P
I
----
D
H
V
G
-
V
Q
R
-
L
K
N
G
L
N
A
V
-
G
V
A
P
I
A
G
R
V
S
G
----
T
I
L
T
A
V
A
D
L
M
A
R
A
G
-
S
-
D
R
I
R
F
T
P
Y
Q
K
L
V
I
L
D
I
P
D
A
L
L
D
D
L
--
I
A
G
L
D
A
-
L
G
L
-
Q
--
S
R
P
S
H
W
R
R
N
L
M
A
C
S
G
I
E
F
C
K
L
S
F
A
E
T
R
V
R
A
Q
-
H
L
V
P
E
L
E
R
R
L
E
D
I
---
N
S
-
Q
L
-
D
V
P
I
T
V
N
I
N
G
C
P
N
S
C
A
R
I
Q
I
A
D
I
G
F
K
G
---
Q
M
I
D
D
GHG
G
S
V
--------
E
G
--------
F
----
Q
V
H
L
G
G
HL
G
L
--
D
A
-
G
F
G
R
K
L
R
Q
-
H
K
V
T
S
D
E
L
G
D
Y
I
D
R
V
-
V
----
R
N
F
V
K
H
R
S
E
G
E
R
F
A
Q
W
V
I
R
A
----------------
6
PsiBlast_PDB
56.21
26%
2
- C3 -
1ZJ8
3
SIR_MYCTU
A:
[99-560]
----------------------------------------------------------------------------------------
K
L
E
A
K
---
Y
-
F
M
M
R
V
R
C
D
G
G
A
L
S
A
A
A
L
R
T
L
G
Q
I
S
-
T
E
F
-
A
-
R
-
D
T
A
D
I
S
D
R
Q
N
V
Q
Y
H
W
I
E
V
E
N
V
P
E
I
W
R
R
L
D
D
V
G
L
Q
T
T
E
A
C
G
D
C
P
R
V
V
L
--
G
S
P
L
A
G
E
S
-
L
D
E
V
-----------
L
D
---
P
T
W
A
I
E
E
I
---
V
R
R
Y
I
---
G
K
P
D
F
A
--------
D
L
P
R
K
Y
K
--
T
A
I
S
G
L
Q
D
V
--
A
H
E
I
N
--
D
V
A
F
I
G
V
N
H
P
E
H
G
P
G
L
D
L
W
V
G
G
G
L
-------
S
T
N
P
M
L
A
Q
R
V
-
G
-
A
W
-
V
P
L
G
E
V
P
E
V
W
A
A
V
T
S
V
F
R
D
Y
G
Y
R
R
L
R
A
K
A
R
L
K
F
L
I
K
D
W
G
I
A
K
F
R
E
V
L
E
T
E
-
Y
L
K
------
R
P
L
I
-
D
G
-
P
A
P
--
E
--
P
V
K
H
P
I
----
D
H
V
G
-
V
Q
R
-
L
K
N
G
L
N
A
V
-
G
V
A
P
I
A
G
R
V
S
G
----
T
I
L
T
A
V
A
D
L
M
A
R
A
G
-
S
-
D
R
I
R
F
T
P
Y
Q
K
L
V
I
L
D
I
P
D
A
L
L
D
D
L
--
I
A
G
L
D
A
-
L
G
L
-
Q
--
S
R
P
S
H
W
R
R
N
L
M
A
C
S
G
I
E
F
C
K
L
S
F
A
E
T
R
V
R
A
Q
-
H
L
V
P
E
L
E
R
R
L
E
D
I
---
N
S
-
Q
L
-
D
V
P
I
T
V
N
I
N
G
C
P
N
S
C
A
R
I
Q
I
A
D
I
G
F
K
G
---
Q
M
I
D
D
GHG
G
S
V
--------
E
G
--------
F
----
Q
V
H
L
G
G
HL
G
L
--
D
A
-
G
F
G
R
K
L
R
Q
-
H
K
V
T
S
D
E
L
G
D
Y
I
D
R
V
-
V
----
R
N
F
V
K
H
R
S
E
G
E
R
F
A
Q
W
V
I
R
A
----------------
33
HHSearch
51.49
22%
18
- C3 -
2AKJ
2
NIR_SPIOL
A:
[88-602]
-----------
S
G
I
N
P
A
E
K
V
K
I
E
K
--
D
P
M
K
L
F
--
I
ED
G
I
S
D
L
A
T
L
S
M
E
E
V
D
KS
K
H
N
K
D
D
I
D
-
V
R
L
K
W
L
G
L
F
H
R
R
K
H
---------------
H
Y
---
G
R
F
M
M
R
L
K
L
P
N
G
V
T
T
S
E
Q
T
R
Y
L
A
S
V
I
-
K
K
Y
-
G
K
D
-
G
C
A
D
V
T
T
R
Q
N
W
Q
I
R
G
V
V
L
P
D
V
P
E
I
I
K
G
L
E
S
V
G
L
T
S
L
Q
S
G
M
D
N
V
R
N
P
V
G
N
P
L
A
G
I
D
P
H
E
I
V
D
T
R
P
F
T
N
L
I
S
Q
F
V
T
A
---
N
S
------------------------
R
G
N
L
S
I
T
N
L
P
R
K
W
N
P
C
V
I
G
S
H
D
L
Y
E
--
H
P
H
I
N
--
D
L
A
Y
M
P
A
T
K
N
-
G
K
F
G
F
N
L
L
V
G
G
F
F
S
I
K
R
------
C
E
E
A
I
P
L
D
A
-
W
V
-
S
A
-
E
D
V
V
P
V
C
K
A
M
L
E
A
F
R
D
L
G
F
R
G
N
R
Q
K
C
R
M
M
W
L
I
D
E
L
G
M
E
A
F
R
G
E
V
E
K
R
-
M
P
E
------
Q
--
V
L
E
R
-
A
S
S
EE
L
VQ
K
D
W
E
R
R
----
E
Y
L
G
V
H
P
Q
K
Q
Q
G
L
S
F
V
G
-
L
H
I
P
-
V
G
R
L
Q
A
----
D
E
M
E
E
L
A
R
I
-
A
D
V
Y
-
G
S
G
E
L
R
L
T
V
E
Q
N
I
I
I
P
N
V
E
N
S
K
I
D
S
L
--
L
N
E
P
L
L
K
E
R
Y
-
S
P
--
E
P
P
I
L
M
K
G
L
V
A
C
T
G
S
Q
F
C
G
Q
A
I
I
E
----
T
K
-
A
R
A
L
K
V
T
E
E
V
Q
R
L
V
S
-----
V
-
T
R
P
V
R
M
H
W
T
G
C
P
N
S
C
G
Q
V
Q
V
A
D
I
G
F
M
G
---
C
--------
M
T
R
D
ENG
K
P
C
E
G
--------
A
----
D
V
F
V
G
G
--
R
I
--
G
S
D
S
H
L
G
D
I
Y
K
-
K
A
V
P
C
K
D
L
V
P
V
V
A
E
I
L
I
----
N
Q
F
G
A
V
P
R
----------------------------
34
HHSearch
51.32
23%
26
- C3 -
3B0G
5
?
A:
[70-584]
----------
R
K
G
I
N
P
Q
E
K
V
K
I
E
K
--
E
P
M
K
L
F
--
M
EN
G
I
E
E
L
A
K
I
P
I
E
E
I
D
Q
S
K
L
T
K
D
D
I
D
-
V
R
L
K
W
L
G
L
F
H
R
R
K
N
---------------
Q
Y
---
G
R
F
M
M
R
L
K
L
P
N
G
V
T
T
S
A
Q
T
R
Y
L
A
S
V
I
-
R
K
Y
-
G
-
K
E
G
C
A
D
I
T
T
R
Q
N
W
Q
I
R
G
V
V
L
P
D
V
P
E
I
L
K
G
L
A
E
V
G
L
T
S
L
Q
S
G
M
D
N
V
R
N
P
V
G
N
P
L
A
G
I
D
P
E
E
I
V
D
T
R
P
Y
T
N
L
L
S
Q
F
I
T
G
NSR
G
N
P
A
V
---------------------------
S
N
L
P
R
K
W
N
P
C
V
V
G
S
H
D
L
Y
E
--
H
P
H
I
N
--
D
L
A
Y
M
P
A
T
K
D
-
G
R
F
G
F
N
L
L
V
G
G
F
F
S
A
K
------
R
C
D
E
A
I
P
L
-
D
A
W
V
-
P
A
-
D
D
V
V
P
V
C
R
A
I
L
E
A
F
R
D
L
G
F
R
G
N
R
Q
K
C
R
M
M
W
L
I
D
E
L
G
V
E
G
F
R
A
E
V
E
K
R
-
M
P
Q
------
Q
Q
-
L
-
E
R
-
A
S
P
ED
L
VQ
K
Q
W
E
R
R
----
D
Y
L
G
V
H
P
Q
K
Q
E
G
Y
S
F
I
G
-
L
H
I
P
-
V
G
R
V
Q
A
----
D
D
M
D
E
L
A
R
L
-
A
D
E
Y
-
G
S
G
E
I
R
L
T
V
E
Q
N
I
I
I
P
N
I
E
T
S
K
I
E
A
L
--
L
K
E
P
V
L
-
S
T
F
-
S
P
--
D
P
P
I
L
M
K
G
L
V
A
C
T
G
N
Q
F
C
G
Q
A
I
I
E
----
T
K
-
A
R
S
L
K
I
T
E
E
V
Q
R
Q
V
S
-----
L
-
T
K
P
V
R
M
H
W
T
G
C
P
N
T
C
A
Q
V
Q
V
A
D
I
G
F
M
G
---
C
--------
L
T
R
D
KNG
K
T
V
E
G
--------
A
----
D
V
F
L
G
G
--
R
I
--
G
S
D
S
H
L
G
E
V
Y
K
-
K
A
V
P
C
D
D
L
V
P
L
V
V
D
L
-
L
V
---
N
N
F
G
A
V
P
R
----------------------------
22
Fugue
50.30
51%
-78
- C3 -
1AOP
2
?
?:
[76-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
D
M
N
R
N
V
L
C
T
S
N
P
Y
E
S
Q
L
-
H
A
E
A
Y
E
W
A
K
K
I
S
E
H
L
L
P
---
T
--------------------------------
Y
L
P
R
K
F
K
T
T
V
V
I
P
P
Q
N
D
I
--
D
L
H
A
N
--
D
M
N
F
V
A
I
A
E
N
G
K
L
V
G
F
N
L
L
V
G
G
G
L
S
I
E
H
G
N
K
K
T
Y
A
R
T
A
S
E
F
-
G
-
Y
L
-
P
L
-
E
H
T
L
A
V
A
E
A
V
V
T
T
Q
R
D
W
G
N
R
T
D
R
K
N
A
K
T
K
Y
T
L
E
R
V
G
V
E
T
F
K
A
E
V
E
R
R
-
A
G
I
------
K
--
F
-
E
P
-
I
R
P
--
Y
--
E
F
T
G
R
G
----
D
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Fugue
49.82
52%
-107
- C3 -
1AOP
2
?
?:
[353-497]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
R
E
N
S
M
A
C
V
S
F
P
T
C
P
L
A
M
A
E
----
A
E
-
R
F
L
P
S
F
I
D
N
I
D
N
L
M
A
K
H
G
-
V
S
-
D
E
H
I
V
M
R
V
T
G
C
P
N
G
C
G
R
A
M
L
A
E
V
G
L
V
G
---
K
--------
A
P
--------
G
R
--------
Y
----
N
L
H
L
G
G
--
N
R
--
I
G
-
T
R
I
P
R
M
Y
K
-
E
N
I
T
E
P
E
I
L
A
S
L
D
E
L
-
I
----
G
R
W
A
K
E
R
E
A
G
E
G
F
G
D
F
T
V
R
A
G
I
I
R
P
V
L
D
P
-
A
R
D
L
W
D
15
PsiBlast_PDB
48.33
24%
27
- C3 -
3B0H
5
?
A:
[131-581]
-------------------------------------------------------------------------------------------------
R
F
M
M
R
L
K
L
P
N
G
V
T
T
S
S
Q
T
R
Y
L
A
S
V
I
-
R
K
Y
-
G
K
D
-
G
C
A
D
V
T
T
R
Q
N
W
Q
I
R
G
V
V
L
P
D
V
P
E
I
L
K
G
L
D
E
V
G
L
T
S
L
Q
S
G
M
D
N
V
R
N
P
V
--
G
N
P
L
A
G
I
D
-
P
H
E
I
V
D
---------------
T
R
P
Y
T
N
L
-
L
S
Q
Y
V
T
A
NFR
G
N
P
--------
A
V
T
N
L
P
R
K
W
N
V
--
C
V
I
G
S
H
D
L
--
Y
E
H
P
Q
IN
D
L
A
Y
M
P
A
T
K
D
G
R
F
-
G
F
N
L
L
V
G
G
F
F
S
P
K
R
C
A
E
A
V
-----
P
L
D
-
A
-
W
V
-
P
A
-
D
D
V
V
P
V
C
K
A
I
L
E
A
Y
R
D
L
G
T
R
G
N
R
Q
K
T
R
M
M
W
L
V
D
E
L
G
V
E
G
F
R
A
E
V
V
K
R
-
M
P
Q
Q
K
L
D
R
E
S
--
T
-
E
D
-
L
V
Q
--
K
--
Q
W
E
R
R
-----
E
Y
L
G
V
H
P
Q
-
K
Q
E
G
Y
S
F
V
G
L
H
I
P
-
V
G
R
V
Q
A
D
D
----
M
D
E
L
A
R
L
-
A
D
E
Y
G
S
-
G
E
L
R
L
T
V
E
Q
N
I
I
I
P
N
V
K
N
S
K
I
E
A
L
L
N
E
P
L
L
K
N
-
R
F
S
-
T
D
P
---
P
I
L
M
K
N
L
V
A
C
T
G
N
Q
F
C
G
K
A
I
I
E
----
T
K
-
A
R
S
M
K
I
T
E
E
V
Q
L
L
V
S
I
T
------
Q
P
V
R
M
H
W
T
G
C
P
N
S
C
A
Q
V
Q
V
A
D
I
G
F
M
G
C
L
T
R
--------
K
E
--------
G
K
--------
T
V
E
G
A
D
V
Y
L
G
G
--
R
I
--
G
S
D
S
H
L
G
D
V
Y
K
-
K
S
V
P
C
E
D
L
V
P
I
I
V
D
L
-
L
V
D
NF
G
A
V
P
R
-------------------------------
14
PsiBlast_PDB
47.00
26%
13
- C3 -
3B0M
5
?
A:
[134-526]
-------------------------------------------------------------------------------------------------
R
F
M
M
R
L
K
L
P
N
G
V
T
T
S
A
Q
T
R
Y
L
A
S
V
I
-
R
K
Y
-
G
-
K
E
G
C
A
D
I
T
T
R
Q
N
W
Q
I
R
G
V
V
L
P
D
V
P
E
I
L
K
G
L
A
E
V
G
L
T
S
L
Q
S
G
K
D
N
V
R
N
P
V
--
G
N
P
L
A
G
I
D
-
P
E
E
I
V
--------
D
T
R
P
---
Y
T
N
L
L
S
Q
F
I
T
G
N
S
R
-----
G
N
P
A
V
S
--------
N
L
P
R
K
W
N
P
C
V
V
G
--
S
H
D
L
YE
H
P
H
I
N
--
D
L
A
Y
M
P
A
T
K
D
G
R
F
-
G
F
N
L
L
V
G
G
F
F
S
A
K
R
C
D
E
A
I
-----
P
L
D
-
A
-
W
V
-
P
A
-
D
D
V
V
P
V
C
R
A
I
L
E
A
F
R
D
L
G
F
R
G
N
R
Q
K
C
R
M
M
W
L
I
D
E
L
G
V
E
G
F
R
A
E
V
E
K
R
-
M
P
Q
------
Q
Q
-
L
-
E
R
-
A
S
P
--
E
--
D
L
V
Q
K
Q
WERR
D
Y
L
G
V
H
P
Q
-
K
Q
E
G
Y
S
F
I
G
L
H
I
P
-
V
G
R
V
Q
A
D
D
----
M
D
E
L
A
R
L
-
A
D
E
Y
G
S
-
G
E
I
R
L
T
V
E
Q
N
I
I
I
P
N
I
E
T
S
K
---
I
--
E
A
L
L
K
E
-
P
V
L
S
T
F
S
P
D
P
P
I
L
M
K
G
L
V
A
C
T
G
N
Q
F
C
G
Q
A
I
I
E
----
T
K
A
R
S
L
-----
K
I
T
E
E
V
Q
R
Q
V
-
S
L
-
T
K
P
V
R
M
H
W
T
G
C
P
N
T
C
A
Q
V
Q
V
A
D
I
G
F
M
G
----------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
46.85
26%
12
- C3 -
3VKP
6
?
A:
[134-526]
-------------------------------------------------------------------------------------------------
R
F
M
M
R
L
K
L
P
N
G
V
T
T
S
A
Q
T
R
Y
L
A
S
V
I
-
R
K
Y
-
G
-
K
E
G
C
A
D
I
T
T
R
Q
N
W
Q
I
R
G
V
V
L
P
D
V
P
E
I
L
K
G
L
A
E
V
G
L
T
S
L
Q
S
G
M
D
N
V
R
N
P
V
--
G
N
P
L
A
G
I
D
-
P
E
E
I
V
--------
D
T
R
P
---
Y
T
N
L
L
S
Q
F
I
T
G
N
S
R
-----
G
N
P
A
V
S
--------
N
L
P
R
K
W
N
P
C
V
V
G
--
S
H
D
L
YE
H
P
H
I
N
--
D
L
A
Y
M
P
A
T
K
D
G
R
F
-
G
F
N
L
L
V
G
G
F
F
S
A
K
R
C
D
E
A
I
-----
P
L
D
-
A
-
W
V
-
P
A
-
D
D
V
V
P
V
C
R
A
I
L
E
A
F
R
D
L
G
F
R
G
N
R
Q
K
C
R
M
M
W
L
I
D
E
L
G
V
E
G
F
R
A
E
V
E
K
R
-
M
P
Q
------
Q
Q
-
L
-
E
R
-
A
S
P
--
E
--
D
L
V
Q
K
Q
WERR
D
Y
L
G
V
H
P
Q
-
K
Q
E
G
Y
S
F
I
G
L
H
I
P
-
V
G
R
V
Q
A
D
D
----
M
D
E
L
A
R
L
-
A
D
E
Y
G
S
-
G
E
I
R
L
T
V
E
Q
N
I
I
I
P
N
I
E
T
S
K
---
I
--
E
A
L
L
K
E
-
P
V
L
S
T
F
S
P
D
P
P
I
L
M
K
G
L
V
A
C
T
G
N
Q
F
C
G
Q
A
I
I
E
----
T
K
A
R
S
L
-----
K
I
T
E
E
V
Q
R
Q
V
-
S
L
-
T
K
P
V
R
M
H
W
T
G
C
P
N
T
C
A
Q
V
Q
V
A
D
I
G
F
M
G
----------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
46.78
26%
11
- C3 -
3VLZ
6
?
A:
[134-526]
-------------------------------------------------------------------------------------------------
R
F
M
M
R
L
K
L
P
N
G
V
T
T
S
A
Q
T
R
Y
L
A
S
V
I
-
R
K
Y
-
G
-
K
E
G
C
A
D
I
T
T
R
Q
N
W
Q
I
R
G
V
V
L
P
D
V
P
E
I
L
K
G
L
A
E
V
G
L
T
S
L
Q
S
G
M
D
N
V
R
N
P
V
--
G
N
P
L
A
G
I
D
-
P
E
E
I
V
--------
D
T
R
P
---
Y
T
N
L
L
S
Q
F
I
T
G
N
S
R
-----
G
N
P
A
V
S
--------
N
L
P
R
K
W
K
P
C
V
V
G
--
S
H
D
L
YE
H
P
H
I
N
--
D
L
A
Y
M
P
A
T
K
D
G
R
F
-
G
F
N
L
L
V
G
G
F
F
S
A
K
R
C
D
E
A
I
-----
P
L
D
-
A
-
W
V
-
P
A
-
D
D
V
V
P
V
C
R
A
I
L
E
A
F
R
D
L
G
F
R
G
N
R
Q
K
C
R
M
M
W
L
I
D
E
L
G
V
E
G
F
R
A
E
V
E
K
R
-
M
P
Q
------
Q
Q
-
L
-
E
R
-
A
S
P
--
E
--
D
L
V
Q
K
Q
WERR
D
Y
L
G
V
H
P
Q
-
K
Q
E
G
Y
S
F
I
G
L
H
I
P
-
V
G
R
V
Q
A
D
D
----
M
D
E
L
A
R
L
-
A
D
E
Y
G
S
-
G
E
I
R
L
T
V
E
Q
N
I
I
I
P
N
I
E
T
S
K
---
I
--
E
A
L
L
K
E
-
P
V
L
S
T
F
S
P
D
P
P
I
L
M
K
G
L
V
A
C
T
G
N
Q
F
C
G
Q
A
I
I
E
----
T
K
A
R
S
L
-----
K
I
T
E
E
V
Q
R
Q
V
-
S
L
-
T
K
P
V
R
M
H
W
T
G
C
P
N
T
C
A
Q
V
Q
V
A
D
I
G
F
M
G
----------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
46.78
26%
13
- C3 -
3VLY
6
?
A:
[134-526]
-------------------------------------------------------------------------------------------------
R
F
M
M
R
L
K
L
P
N
G
V
T
T
S
A
Q
T
R
Y
L
A
S
V
I
-
R
K
Y
-
G
-
K
E
G
C
A
D
I
T
T
R
Q
N
W
Q
I
R
G
V
V
L
P
D
V
P
E
I
L
K
G
L
A
E
V
G
L
T
S
L
Q
S
G
M
D
N
V
R
N
P
V
--
G
N
P
L
A
G
I
D
-
P
E
E
I
V
--------
D
T
R
P
---
Y
T
N
L
L
S
Q
F
I
T
G
N
S
R
-----
G
N
P
A
V
S
--------
N
L
P
R
K
W
K
P
C
V
V
G
--
S
H
D
L
YE
H
P
H
I
N
--
D
L
A
Y
M
P
A
T
K
D
G
R
F
-
G
F
N
L
L
V
G
G
F
F
S
A
K
R
C
D
E
A
I
-----
P
L
D
-
A
-
W
V
-
P
A
-
D
D
V
V
P
V
C
R
A
I
L
E
A
F
R
D
L
G
F
R
G
N
R
Q
K
C
R
M
M
W
L
I
D
E
L
G
V
E
G
F
R
A
E
V
E
K
R
-
M
P
Q
------
Q
Q
-
L
-
E
R
-
A
S
P
--
E
--
D
L
V
Q
K
Q
WERR
D
Y
L
G
V
H
P
Q
-
K
Q
E
G
Y
S
F
I
G
L
H
I
P
-
V
G
R
V
Q
A
D
D
----
M
D
E
L
A
R
L
-
A
D
E
Y
G
S
-
G
E
I
R
L
T
V
E
Q
N
I
I
I
P
N
I
E
T
S
K
---
I
--
E
A
L
L
K
E
-
P
V
L
S
T
F
S
P
D
P
P
I
L
M
K
G
L
V
A
C
T
G
N
Q
F
C
G
Q
A
I
I
E
----
T
K
A
R
S
L
-----
K
I
T
E
E
V
Q
R
Q
V
-
S
L
-
T
K
P
V
R
M
H
W
T
G
C
P
N
T
C
A
Q
V
Q
V
A
D
I
G
F
M
G
----------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
46.66
26%
15
- C3 -
3VM0
6
?
A:
[134-526]
-------------------------------------------------------------------------------------------------
R
F
M
M
R
L
K
L
P
N
G
V
T
T
S
A
Q
T
R
Y
L
A
S
V
I
-
R
K
Y
-
G
-
K
E
G
C
A
D
I
T
T
R
Q
N
W
Q
I
R
G
V
V
L
P
D
V
P
E
I
L
K
G
L
A
E
V
G
L
T
S
L
Q
S
G
M
D
N
V
R
N
P
V
--
G
N
P
L
A
G
I
D
-
P
E
E
I
V
--------
D
T
R
P
---
Y
T
N
L
L
S
Q
F
I
T
G
N
S
R
-----
G
N
P
A
V
S
--------
N
L
P
R
K
W
K
P
C
V
V
G
--
S
H
D
L
YE
H
P
H
I
N
--
D
L
A
Y
M
P
A
T
K
D
G
R
F
-
G
F
N
L
L
V
G
G
F
F
S
A
K
R
C
D
E
A
I
-----
P
L
D
-
A
-
W
V
-
P
A
-
D
D
V
V
P
V
C
R
A
I
L
E
A
F
R
D
L
G
F
R
G
N
R
Q
K
C
R
M
M
W
L
I
D
E
L
G
V
E
G
F
R
A
E
V
E
K
R
-
M
P
Q
------
Q
Q
-
L
-
E
R
-
A
S
P
--
E
--
D
L
V
Q
K
Q
WERR
D
Y
L
G
V
H
P
Q
-
K
Q
E
G
Y
S
F
I
G
L
H
I
P
-
V
G
R
V
Q
A
D
D
----
M
D
E
L
A
R
L
-
A
D
E
Y
G
S
-
G
E
I
R
L
T
V
E
Q
N
I
I
I
P
N
I
E
T
S
K
---
I
--
E
A
L
L
K
E
-
P
V
L
S
T
F
S
P
D
P
P
I
L
M
K
G
L
V
A
C
T
G
N
Q
F
C
G
Q
A
I
I
E
----
T
K
A
R
S
L
-----
K
I
T
E
E
V
Q
R
Q
V
-
S
L
-
T
K
P
V
R
M
H
W
T
G
C
P
N
T
C
A
Q
V
Q
V
A
D
I
G
F
M
G
----------------------------------------------------------------------------------------------------------------------
25
Fugue
35.94
45%
-98
- C3 -
1AOP
2
?
?:
[8-101]
---------------------------------------------------------------------------------------------------
L
L
R
C
R
L
P
G
G
V
I
T
T
K
Q
W
Q
A
I
D
K
F
A
-
G
E
N
T
I
-
Y
-
G
S
I
R
L
T
N
R
Q
T
F
Q
F
H
G
I
L
P
-----
V
H
Q
M
L
H
S
V
G
L
D
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------