@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu33500: (2016-07-26 )
MSEQKEIAMQVSGMTCAACAARIEKGLKRMPGVTDANVNLATETSNVIYDPAETGTAAIQEKIEKLGYHVVTEKAEFDIEGMTCAACANRIEKRLNKIEGVANAPVNFALETVTVEYNPKEASVSDLKEAVDKLGYKLKLKGEQDSEAAAKKKEERKQTARLIFSAVLSFPLLWAMVSHFTFTSFIWVPDIFLNPWMQFALATPVQFLIGWPFYVGAYKALRNKSANMDVLVALGTTAAYAYSLYLTFQSIGSHGHTDGLYYETSAILLTLILLGKLFETKAKGRSSDAIKKLMKLQAKTATVVRDGQEQIIPIDEVLVNDIVYVKPGERIPVDGEVVEGRSAVDESMITGESLPVDKNPGDSVTGSTVNANGFLKIKAVNVGKDTALSHIIKIVEEAQGSKAPIQRLADQISGIFVPIVLGIAVLTFLIWYLWAAPGDFAEAISKFIAVLVIACPCALGLATPTSIMAGSGRAAEFGILFKGGEHLEKTHRLDTIVLDKTGTVTNGKPRLTDAIPFGRFEEKDLLQFAAAAETGSEHPLGEAIIAGVKDKGLEIPKLTRFEAKVGAGILAEAGGKSILVGTRKLMESEQVEHGALLAQMEELEAEGKTVMLVSIDGEAAGLVAVADTIKDTSRKAVARLKELGLDVIMMTGDNRRTAEAIAKEAGIANIIAEVLPEQKAAEIARLQKEGRQTAMVGDGINDAPALATADIGMAIGTGTDIAMETADITLIRGDLNSIADAIRMSRLTMKNIKQNLFWALGYNSLGIPIAALGFLAPWIAGAAMAFSSVSVVLNALRLQKVK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.-......160.......170..-.....180.......190.......200.......210.......220..-.....230.......240.....-.------.250......-----.260....---...270.......280.......290.......300...-....310.......320.......330.......340........350.......360---------..----------......370.......380.......390.......400.......410.......420.......430...-....440.......450.......460.......470.......480.......490.......500.......510.......520------------------.-------------------.---.....---.530------.-------------.----------------.....540----------.......550.-------.-------..--..--.560......------------------------.570..----.----.--....580....---------.------..590.--------------.-.....600.......610...------------------------....---------------------620.......630.......640.......650.......660......-----------------------------------------------------.-----------------------------------------------------670.......680.......690.......700.......710....-...720.......730.......740.......750.......760.......770-----..-------.-------..----..--------.780.......790.......800-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
E
Q
K
E
I
A
M
Q
VSG
M
T
C
A
A
C
A
A
R
I
E
K
G
L
K
RMPGVTDAN
V
N
L
ATETS
N
V
I
YDPAET
G
T
A
A
I
Q
E
K
I
E
KLG
Y
H
V
VTEKAEFDIEGM
T
C
A
A
C
A
N
R
I
E
K
R
L
N
K
I
EGVANAP
V
N
F
A
L
E
T
V
T
V
E
YNPKEA
S
V
S
D
L
K
E
A
V
D
KL
G
Y
K
L
K
LKGEQD
S
E
A
A
A
K
K
K
-
E
E
R
K
Q
T
A
R
L
I
F
S
A
V
L
S
F
P
L
L
W
-
A
M
V
S
H
FT
F
T
S
F
I
WV
P
D
I
F
L
N
P
W
M
Q
F
A
L
A
T
P
V
Q
F
L
IGW
P
F
Y
V
G
A
Y
K
A
L
RNK-SAN
M
D
V
L
V
A
LGTT
A
A
Y
A
Y
S
L
Y
L
T
-
F
------
Q
S
IGSHGHTD-----
G
L
Y
Y
E
T
S
A
---
I
L
L
T
L
I
L
L
G
K
L
F
E
T
KAKGR
S
S
D
A
I
K
K
L
M
K
L
QAK
T
A
T
V
VR-DGQE
Q
I
I
P
I
D
E
V
L
V
N
D
I
V
Y
VKPGERIPVDGEVVEGR-SAVDESMITGESLPVDKNPG----------DS----------VTG
S
T
VNAN
G
F
L
K
I
K
A
V
NVG
K
D
T
A
L
S
H
I
I
K
I
V
E
E
AQGSK
A
P
I
Q
R
L
A
D
Q
IS
G
I
F
V
P
I
V
L
G
I
A
V
L
T
F
L
I
W
Y
L
WA-AP
G
D
F
A
E
A
I
S
K
F
I
A
V
L
V
I
ACPCALGLATP
T
S
IMAGSGRA
A
E
F
G
I
L
FKGG
E
H
L
E
K
THRL
D
T
I
V
LDKTGTVTNGKPRLTDAIPFGRF
E
-------------------
E
-------------------
K
---
D
L
L
Q
F
---
A
A
AA------E-------------T----------------GSEHP
L
G
E
----------
A
I
I
AGVKDKGL-------E-------IP--KL--
T
R
F
E
AKVGA
G
------------------------
I
LA-EA----G----G--
K
S
I
L
V
G
T
R
K
L
M
---------
E
------
S
E
Q
V
E
H
--------------
G
-
A
L
L
A
Q
M
E
E
LEAEG
K
T
V
M
L
V
S
I------------------------DGEA---------------------A
G
L
V
A
V
A
D
T
I
K
D
T
S
R
K
A
V
A
R
L
K
ELG
L
D
V
I
M
MTGDNR
R
T
A
E
A
I
A
K
EA
G
I
A
-----------------------------------------------------
N
-----------------------------------------------------
I
I
A
E
VLP
E
Q
K
A
A
E
I
A
R
L
Q
K
EGR
Q
T
A
MVGDGINDAP
A
L
A
T
A
D
I
G
M
A
IG-TGT
D
I
A
M
ET
A
D
I
T
L
I
R
G
D
L
N
S
I
A
D
A
I
R
M
S
R
L
T
M
K
N
I
K
Q
N
L
F
W
A
LGYNSLG
I
P
I
A
A
------
L
G
-------
F
-------
L
A
----
P
W
--------
I
A
G
A
A
M
A
F
S
S
V
S
V
V
L
N
A
L
R
LQKVK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
75.60
45%
-37
- C1 -
3J09
-
COPA_ARCFU
A:
[17-729]
-------------------------------------------------------------------------
E
R
T
V
R
V
T
G
M
T
C
A
M
C
V
K
S
I
E
T
A
V
G
S
L
E
G
V
E
E
V
R
V
N
L
A
T
E
T
A
F
I
R
F
D
E
K
R
I
D
F
E
T
I
K
R
V
I
E
D
L
G
Y
G
V
V
D
E
Q
A
A
V
S
A
E
V
---
E
-
H
L
S
R
M
K
R
K
L
Y
V
A
A
F
A
G
V
L
L
L
F
L
A
H
F
I
----
S
-------
L
P
Y
E
D
F
V
Q
L
L
I
A
L
P
A
I
F
Y
S
G
S
S
I
F
K
A
A
F
S
A
L
R
R
R
-
T
L
N
M
D
V
M
Y
S
M
G
V
G
A
A
F
L
A
S
V
L
S
T
-
A
------
G
V
----
L
P
R
E
-----
Y
S
F
Y
E
T
S
V
---
L
L
L
A
F
L
L
L
G
R
T
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
T
A
V
V
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R
-
D
G
K
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V
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V
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P
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K
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P
V
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G
V
V
V
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G
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-
S
Y
V
D
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S
M
I
S
G
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P
V
P
V
L
K
S
K
G
----------
D
E
----------
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
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K
L
V
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D
A
M
G
S
K
P
P
I
Q
R
L
A
D
K
V
V
A
Y
F
I
P
T
V
L
L
V
A
I
S
A
F
I
Y
W
Y
F
I
A
-
H
-
A
P
L
L
F
A
F
T
T
L
I
A
V
L
V
V
A
C
P
C
A
F
G
L
A
T
P
T
A
L
T
V
G
M
G
K
G
A
E
L
G
I
L
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K
N
A
D
A
L
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V
A
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K
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T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
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D
L
V
P
L
N
G
-
D
-------------------
E
-------------------
R
---
E
L
L
R
L
---
A
A
I
A
------
E
-------------
R
----------------
R
S
E
H
P
I
A
E
----------
A
I
V
K
K
A
L
E
H
G
I
-------
E
-------
L
G
--
E
P
--
E
K
V
E
V
I
A
G
E
G
------------------------
V
V
A
---------------
D
G
I
L
V
G
N
K
R
L
M
---------
E
------
D
F
G
V
A
V
--------------
S
N
E
V
E
L
A
L
E
K
L
E
R
E
A
K
T
A
V
I
V
A
R
------------------------
N
G
R
V
---------------------
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
D
-----------------------------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
-
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
L
I
Y
N
V
I
L
I
P
A
A
A
------
G
L
L
Y
P
IFGV
V
-------
F
R
----
P
E
--------
F
A
G
L
A
M
A
M
S
S
V
S
V
V
A
N
S
L
L
L
R
N
Y
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
74.54
45%
-24
- C1 -
3J09
-
COPA_ARCFU
A:
[22-726]
------------------------------------------------------------------------------
V
T
G
M
T
C
A
M
C
V
K
S
I
E
T
A
V
G
S
L
E
G
V
E
E
V
R
V
N
L
A
T
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T
A
F
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R
F
D
E
K
R
I
D
F
E
T
I
K
R
V
I
E
D
L
G
Y
-----
G
V
V
D
E
Q
A
A
V
S
A
E
V
E
H
L
S
R
M
K
R
K
L
Y
V
A
A
F
A
G
V
L
L
L
--
F
L
A
H
F
-----
I
S
L
P
---
Y
E
D
F
V
Q
L
L
I
A
L
P
A
I
F
Y
S
G
S
S
I
F
K
A
A
F
S
A
L
R
R
R
-
T
L
N
M
D
V
M
Y
S
M
G
V
G
A
A
F
L
A
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V
-
L
S
-
T
------
A
G
V
L
P
R
E
Y
S
--------
F
Y
E
T
S
V
---
L
L
L
A
F
L
L
L
G
R
T
L
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A
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----------
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----------
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V
P
L
N
G
-
D
-------------------
E
-------------------
R
---
E
L
L
R
L
---
A
A
I
A
------
E
-------------
R
----------------
R
S
E
H
P
I
A
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----------
A
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L
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-------
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-------
L
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--
E
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--
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K
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V
I
A
G
E
G
------------------------
V
V
A
-
D
G
--------------
I
L
V
G
N
K
R
L
M
---------
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D
F
G
V
A
V
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N
E
V
E
L
--------------
A
------
L
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L
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R
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A
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T
A
V
I
V
A
R
------------------------
N
G
R
V
---------------------
E
G
I
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A
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S
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T
L
K
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S
A
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A
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M
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M
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T
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D
N
W
R
S
A
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A
I
S
R
E
L
N
L
D
-----------------------------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
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S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
L
I
Y
N
V
I
L
I
P
-
A
A
------
A
G
-------
L
-------
L
Y
----
P
I
FGVVFR
P
E
F
A
G
L
A
M
A
M
S
S
V
S
V
V
A
N
S
L
L
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
Fugue
72.30
43%
-9
- C1 -
3RFU
3
?
A:
[74-736]
-------------------------------------------------------------------------------------------------------------------------------------------------
V
S
P
E
Y
L
D
M
-
R
R
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
G
-
H
G
L
K
H
F
I
S
G
N
--------
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
W
P
F
F
K
R
G
W
Q
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L
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T
G
-
Q
L
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T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
L
W
------
P
G
V
F
P
H
A
F
R
S
QEGVV
A
V
Y
F
E
A
A
A
---
V
I
T
T
L
V
L
L
G
Q
V
L
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-------------------
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-------------------
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---
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A
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---
A
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------
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----------------
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----------
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------------------------
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---------------------
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-----------------------------------------------------
K
-----------------------------------------------------
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----
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--------
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V
S
V
I
I
N
A
L
R
L
K
R
V
T
L----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
Fugue
71.49
35%
-91
- C1 -
4UMW
2
?
A:
[124-730]
-----------------------------------------------------------------------------------------
R
L
K
E
N
L
P
L
I
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L
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A
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----------------------
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---------------------------------------------------
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-------------------
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----------------
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------------------------
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----
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----
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A
--------------------
A
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K
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A
--------------
D
-
A
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L
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A
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V
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------------------------
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D
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V
---------------------
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L
G
L
------------------------------------------------------
E
-----------------------------------------------------
F
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--------
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L
V
T
A
N
A
L
R
L
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
71.49
45%
-4
- C1 -
3RFU
3
?
C:
[116-734]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
W
P
F
F
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A
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-
L
WPGVFP
H
A
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R
S
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V
V
-----
A
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Y
F
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A
---
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---
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A
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---
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------
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-------------
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----------------
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P
L
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----------
A
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-------
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-------
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--
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A
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T
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------------------------
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----
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----
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--
H
H
V
A
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---------
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------
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H
G
G
D
N
--------------
A
-
P
L
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A
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G
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G
A
S
V
M
F
M
A
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------------------------
D
G
K
T
---------------------
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A
L
L
V
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D
P
I
K
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S
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I
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I
V
M
L
T
G
D
S
K
R
T
A
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A
V
A
G
T
L
G
I
K
-----------------------------------------------------
K
-----------------------------------------------------
V
V
A
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P
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D
K
S
R
I
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S
E
L
K
D
K
G
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A
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N
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A
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A
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A
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N
V
L
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V
P
L
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A
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T
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L------
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-------
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S
----
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M
--------
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A
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A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
R
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
71.28
45%
-5
- C1 -
3RFU
3
?
D:
[116-734]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
W
P
F
F
K
R
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A
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L
WPGVFP
H
A
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V
V
-----
A
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Y
F
E
A
A
A
---
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----------
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----------
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V
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V
-------------------
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---
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A
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A
L
---
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A
A
L
------
E
-------------
H
----------------
Q
S
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L
A
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----------
A
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V
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A
A
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--
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A
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T
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------------------------
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----
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--
H
H
V
A
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---------
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------
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H
G
G
D
N
--------------
A
-
P
L
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A
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R
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G
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V
M
F
M
A
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------------------------
D
G
K
T
---------------------
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A
L
L
V
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D
P
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K
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S
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V
M
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T
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D
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K
R
T
A
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A
V
A
G
T
L
G
I
K
-----------------------------------------------------
K
-----------------------------------------------------
V
V
A
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M
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R
I
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S
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L
K
D
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G
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N
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A
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A
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A
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N
V
L
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V
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L
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T
G
L------
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-------
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M
--------
I
A
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A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
R
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
71.23
45%
-4
- C1 -
3RFU
3
?
B:
[116-734]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
-
Q
L
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
-
L
WPGVFP
H
A
F
R
S
Q
E
G
V
V
-----
A
V
Y
F
E
A
A
A
---
V
I
T
T
L
V
L
L
G
Q
V
L
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L
K
A
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Q
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G
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A
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R
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L
L
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L
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S
A
H
R
I
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E
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V
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L
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N
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A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
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D
G
E
V
Q
E
G
R
-
S
F
V
D
E
S
M
V
T
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E
P
I
P
V
A
K
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
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A
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I
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M
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D
A
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L
A
D
T
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W
F
V
P
A
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I
L
V
A
V
L
S
F
I
V
W
A
L
L
G
-
P
Q
P
A
L
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Y
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L
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A
V
S
V
L
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I
A
C
P
C
A
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A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
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V
L
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N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
-
I
V
T
D
D
F
V
-------------------
E
-------------------
D
---
N
A
L
A
L
---
A
A
A
L
------
E
-------------
H
----------------
Q
S
E
H
P
L
A
N
----------
A
I
V
H
A
A
K
E
K
G
L
-------
S
-------
L
G
--
S
V
--
E
A
F
E
A
P
T
G
K
G
------------------------
V
V
G
-
Q
V
----
D
----
G
--
H
H
V
A
I
G
N
A
R
L
M
---------
Q
------
E
H
G
G
D
N
--------------
A
-
P
L
F
E
K
A
D
E
L
R
G
K
G
A
S
V
M
F
M
A
V
------------------------
D
G
K
T
---------------------
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
K
-----------------------------------------------------
K
-----------------------------------------------------
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
I
Y
N
V
L
G
V
P
L
A
A
GVLYPL
T
G
L------
L
-------
L
S
----
P
M
--------
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
R
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
70.99
45%
-4
- C1 -
3RFU
3
?
A:
[116-734]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
-
Q
L
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
-
L
WPGVFP
H
A
F
R
S
Q
E
G
V
V
-----
A
V
Y
F
E
A
A
A
---
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
G
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
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K
I
P
V
D
G
E
V
Q
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G
R
-
S
F
V
D
E
S
M
V
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P
I
P
V
A
K
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
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D
T
M
L
A
R
I
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Q
M
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D
A
Q
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A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
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I
L
V
A
V
L
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F
I
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W
A
L
L
G
-
P
Q
P
A
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Y
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A
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V
L
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I
A
C
P
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M
S
I
M
V
G
V
G
K
G
A
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V
L
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N
A
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A
L
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M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
-
I
V
T
D
D
F
V
-------------------
E
-------------------
D
---
N
A
L
A
L
---
A
A
A
L
------
E
-------------
H
----------------
Q
S
E
H
P
L
A
N
----------
A
I
V
H
A
A
K
E
K
G
L
-------
S
-------
L
G
--
S
V
--
E
A
F
E
A
P
T
G
K
G
------------------------
V
V
G
-
Q
V
----
D
----
G
--
H
H
V
A
I
G
N
A
R
L
M
---------
Q
------
E
H
G
G
D
N
--------------
A
-
P
L
F
E
K
A
D
E
L
R
G
K
G
A
S
V
M
F
M
A
V
------------------------
D
G
K
T
---------------------
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
K
-----------------------------------------------------
K
-----------------------------------------------------
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
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D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
I
Y
N
V
L
G
V
P
L
A
A
GVLYPL
T
G
L------
L
-------
L
S
----
P
M
--------
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
R
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
70.89
45%
-3
- C1 -
4BEV
2
?
A:
[116-734]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
-
Q
L
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
-
L
WPGVFP
H
A
F
R
S
Q
E
G
V
V
-----
A
V
Y
F
E
A
A
A
---
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
G
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
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D
A
Q
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A
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I
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L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
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F
I
V
W
A
L
L
G
-
P
Q
P
A
L
S
Y
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
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L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
-
I
V
T
D
D
F
V
-------------------
E
-------------------
D
---
N
A
L
A
L
---
A
A
A
L
------
E
-------------
H
----------------
Q
S
E
H
P
L
A
N
----------
A
I
V
H
A
A
K
E
K
G
L
-------
S
-------
L
G
--
S
V
--
E
A
F
E
A
P
T
G
K
G
------------------------
V
V
G
-
Q
V
----
D
----
G
--
H
H
V
A
I
G
N
A
R
L
M
---------
Q
------
E
H
G
G
D
N
--------------
A
-
P
L
F
E
K
A
D
E
L
R
G
K
G
A
S
V
M
F
M
A
V
------------------------
D
G
K
T
---------------------
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
K
-----------------------------------------------------
K
-----------------------------------------------------
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
I
Y
N
V
L
G
V
P
L
A
A
GVLYPL
T
G
L------
L
-------
L
S
----
P
M
--------
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
R
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
70.63
45%
-4
- C1 -
4BYG
4
?
A:
[116-734]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
G
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
-
Q
L
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
-
L
WPGVFP
H
A
F
R
S
Q
E
G
V
V
-----
A
V
Y
F
E
A
A
A
---
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
G
S
E
E
E
V
S
L
D
N
V
A
V
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
W
A
L
L
G
-
P
Q
P
A
L
S
Y
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
P
K
L
T
R
-
I
V
T
D
D
F
V
-------------------
E
-------------------
D
---
N
A
L
A
L
---
A
A
A
L
------
E
-------------
H
----------------
Q
S
E
H
P
L
A
N
----------
A
I
V
H
A
A
K
E
K
G
L
-------
S
-------
L
G
--
S
V
--
E
A
F
E
A
P
T
G
K
G
------------------------
V
V
G
-
Q
V
----
D
----
G
--
H
H
V
A
I
G
N
A
R
L
M
---------
Q
------
E
H
G
G
D
N
--------------
A
-
P
L
F
E
K
A
D
E
L
R
G
K
G
A
S
V
M
F
M
A
V
------------------------
D
G
K
T
---------------------
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
K
-----------------------------------------------------
K
-----------------------------------------------------
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
A
F
I
Y
N
V
L
G
V
P
L
A
A
GVLYPL
T
G
L------
L
-------
L
S
----
P
M
--------
I
A
A
A
A
M
A
L
S
S
V
S
V
I
I
N
A
L
R
L
K
R
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
70.04
49%
-56
- C1 -
3J08
-
COPA_ARCFU
A:
[125-728]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
V
Q
L
L
I
A
L
P
A
I
F
Y
S
G
S
S
I
F
K
A
A
F
S
A
L
R
R
R
-
T
L
N
M
D
V
M
Y
S
M
G
V
G
A
A
F
L
A
S
V
L
S
T
-
A
------
G
V
L
----
P
R
E
-----
Y
S
F
Y
E
T
S
V
---
L
L
L
A
F
L
L
L
G
R
T
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
T
A
V
V
I
R
-
D
G
K
E
I
A
V
P
V
E
E
V
A
V
G
D
I
V
I
V
R
P
G
E
K
I
P
V
D
G
V
V
V
E
G
E
-
S
Y
V
D
E
S
M
I
S
G
E
P
V
P
V
L
K
S
K
G
----------
D
E
----------
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
L
V
E
D
A
M
G
S
K
P
P
I
Q
R
L
A
D
K
V
V
A
Y
F
I
P
T
V
L
L
V
A
I
S
A
F
I
Y
W
Y
F
I
A
-
H
-
A
P
L
L
F
A
F
T
T
L
I
A
V
L
V
V
A
C
P
C
A
F
G
L
A
T
P
T
A
L
T
V
G
M
G
K
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
V
P
L
N
G
-
D
-------------------
E
-------------------
R
---
E
L
L
R
L
---
A
A
I
A
------
E
-------------
R
----------------
R
S
E
H
P
I
A
E
----------
A
I
V
K
K
A
L
E
H
G
I
-------
E
-------
L
G
--
E
P
--
E
K
V
E
V
I
A
G
E
G
------------------------
V
V
A
---------------
D
G
I
L
V
G
N
K
R
L
M
---------
E
------
D
F
G
V
A
V
--------------
S
N
E
V
E
L
A
L
E
K
L
E
R
E
A
K
T
A
V
I
V
A
R
------------------------
N
G
R
V
---------------------
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
D
-----------------------------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
-
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
L
I
Y
N
V
I
L
I
P
A
A
A
------
G
L
L
Y
P
IFGV
V
-------
F
R
----
P
E
--------
F
A
G
L
A
M
A
M
S
S
V
S
V
V
A
N
S
L
L
L
R
N
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
67.39
47%
-26
- C1 -
3J08
-
COPA_ARCFU
A:
[107-726]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-
A
G
V
L
L
L
F
L
A
H
F
I
S
L
P
---
Y
E
D
F
V
Q
L
L
I
A
L
P
A
I
F
Y
S
G
S
S
I
F
K
A
A
F
S
A
L
R
R
R
-
T
L
N
M
D
V
M
Y
S
M
G
V
G
A
A
F
L
A
S
V
-
L
S
-
T
------
A
G
V
L
P
R
E
Y
S
--------
F
Y
E
T
S
V
---
L
L
L
A
F
L
L
L
G
R
T
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
T
A
V
V
I
R
-
D
G
K
E
I
A
V
P
V
E
E
V
A
V
G
D
I
V
I
V
R
P
G
E
K
I
P
V
D
G
V
V
V
E
G
E
-
S
Y
V
D
E
S
M
I
S
G
E
P
V
P
V
L
K
S
K
G
----------
D
E
----------
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
L
V
E
D
A
M
G
S
K
P
P
I
Q
R
L
A
D
K
V
V
A
Y
F
I
P
T
V
L
L
V
A
I
S
A
F
I
Y
W
Y
F
I
A
H
A
P
L
L
F
--
A
F
T
T
L
I
A
V
L
V
V
A
C
P
C
A
F
G
L
A
T
P
T
A
L
T
V
G
M
G
K
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
P
E
V
T
D
L
V
P
L
N
G
-
D
-------------------
E
-------------------
R
---
E
L
L
R
L
---
A
A
I
A
------
E
-------------
R
----------------
R
S
E
H
P
I
A
E
----------
A
I
V
K
K
A
L
E
H
G
I
-------
E
-------
L
G
--
E
P
--
E
K
V
E
V
I
A
G
E
G
------------------------
V
V
A
-
D
G
--------------
I
L
V
G
N
K
R
L
M
---------
E
D
F
G
V
A
V
S
N
E
V
E
L
--------------
A
------
L
E
K
L
E
R
E
A
K
T
A
V
I
V
A
R
------------------------
N
G
R
V
---------------------
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
D
-----------------------------------------------------
L
-----------------------------------------------------
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
A
L
I
Y
N
V
I
L
I
P
A
A
A
-------
G
-------
L
-------
L
Y
----
P
I
FGVVFR
P
E
F
A
G
L
A
M
A
M
S
S
V
S
V
V
A
N
S
L
L
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
65.03
33%
-26
- C1 -
4UMW
2
?
A:
[124-730]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
K
E
N
L
P
L
I
T
L
--
I
V
M
M
A
I
S
W
G
--
L
E
-
Q
-
F
-----
N
H
P
F
G
Q
L
A
F
I
A
---
T
T
L
V
G
L
Y
P
I
A
R
Q
A
L
R
L
I
K
S
G
S
Y
F
A
I
E
T
L
M
S
V
A
A
I
G
A
L
F
I
G
A
-----------------------------
T
A
E
A
A
---
M
V
L
L
L
F
L
I
G
E
R
L
E
G
W
A
A
S
R
----
V
S
A
L
M
A
L
K
P
E
T
A
T
R
L
R
-
N
G
E
R
E
E
V
A
I
N
S
L
R
P
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
S
P
F
-
A
S
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
A
T
G
----------
D
K
----------
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
I
D
R
I
L
K
L
I
E
E
A
E
E
R
R
A
P
I
E
R
F
I
D
R
F
S
R
I
Y
T
P
A
I
M
A
V
A
L
L
V
T
L
V
P
P
L
L
F
-
A
-
A
S
W
Q
E
W
I
Y
K
G
L
T
L
L
L
I
G
C
P
C
A
L
V
I
S
T
P
A
A
I
T
S
G
L
A
A
A
A
R
R
G
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
P
R
V
T
A
I
H
P
A
T
G
I
S
-------------------
E
-------------------
S
---
E
L
L
T
L
---
A
A
A
V
------
E
-------------
Q
----------------
G
A
T
H
P
L
A
Q
----------
A
I
V
R
E
A
Q
V
A
E
L
-------
A
-------
I
P
--
T
A
--
E
S
Q
R
A
L
V
G
S
G
------------------------
I
E
A
-
Q
V
----
N
----
G
--
E
R
V
L
I
C
A
A
G
K
H
---------
P
------
A
D
--------------------
A
F
A
G
L
I
N
E
L
E
S
A
G
Q
T
V
V
L
V
V
R
------------------------
N
D
D
V
---------------------
L
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
L
E
-----------------------------------------------------------------------------------------------------------
F
K
A
G
L
L
P
E
D
K
V
K
A
V
T
K
L
N
Q
H
-
A
P
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
-
S
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
L
G
L
K
G
I
F
L
V
T
T
L
------
L
G
-------
M
-------
T
G
----
L
W
--------
L
A
V
L
A
D
T
G
A
T
V
L
V
T
A
N
A
L
R
L
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
63.54
33%
-16
- C1 -
4UMW
2
?
A:
[124-730]
------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
K
-
E
--------------
N
L
P
L
I
T
-
L
I
V
----
M
M
A
I
S
W
G
L
E
Q
F
N
H
P
F
G
Q
L
A
F
I
A
T
T
--
L
V
G
--
L
Y
P
I
A
R
Q
A
L
R
---------
L
I
K
S
G
S
--------
Y
F
A
-
I
------
E
T
L
M
S
V
A
A
I
G
-----
A
L
F
I
G
A
T
A
E
A
A
M
V
L
L
L
F
L
I
G
E
R
L
E
G
W
A
A
S
R
----
V
S
A
L
M
A
L
K
P
E
T
A
T
R
L
R
-
N
G
E
R
E
E
V
A
I
N
S
L
R
P
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
S
P
F
-
A
S
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
A
T
G
----------
D
K
----------
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
I
D
R
I
L
K
L
I
E
E
A
E
E
R
R
A
P
I
E
R
F
I
D
R
F
S
R
I
Y
T
P
A
I
M
A
V
A
L
L
V
T
L
V
P
P
L
L
F
-
A
-
A
S
W
Q
E
W
I
Y
K
G
L
T
L
L
L
I
G
C
P
C
A
L
V
I
S
T
P
A
A
I
T
S
G
L
A
A
A
A
R
R
G
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
P
R
V
T
A
I
H
P
A
T
G
I
S
-------------------
E
-------------------
S
---
E
L
L
T
L
---
A
A
A
V
------
E
-------------
Q
----------------
G
A
T
H
P
L
A
Q
----------
A
I
V
R
E
A
Q
V
A
E
L
-------
A
-------
I
P
--
T
A
--
E
S
Q
R
A
L
V
G
S
G
------------------------
I
E
A
-
Q
V
----
N
----
G
--
E
R
V
L
I
C
A
A
G
K
H
---------
P
------
A
D
--------------------
A
F
A
G
L
I
N
E
L
E
S
A
G
Q
T
V
V
L
V
V
R
------------------------
N
D
D
V
---------------------
L
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
L
------------------------------------------------------
E
-----------------------------------------------------
F
K
A
G
L
L
P
E
D
K
V
K
A
V
T
K
L
N
Q
H
A
-
P
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
-
S
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
L
G
L
K
G
I
F
L
V
T
T
L
------
L
G
-------
M
-------
T
G
----
L
W
--------
L
A
V
L
A
D
T
G
A
T
V
L
V
T
A
N
A
L
R
L
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
HHSearch
62.26
26%
-
- C1 -
3IXZ
-
ATP4A_PIG
A:
[143-800]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---
A
L
I
A
V
V
V
V
T
G
C
F
G
Y
Y
Q
E
F
K
S
T
N
I
I
A
S
F
K
N
L
V
P
Q
Q
A
T
V
I
R
-
D
G
D
K
F
Q
I
N
A
D
Q
L
V
V
G
D
L
V
E
M
K
G
G
D
R
V
P
A
D
I
R
I
L
Q
A
Q
G
R
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
C
T
H
ESPLETR
N
I
----------
A
F
F
S
T
M
C
L
E
G
T
A
Q
G
L
V
V
N
T
G
D
R
T
I
I
G
R
I
A
S
L
A
S
G
V
E
N
E
K
T
P
I
A
I
E
I
E
H
F
V
D
I
I
A
G
L
A
I
L
F
G
A
T
F
F
I
V
A
M
C
I
G
-
Y
--
T
F
L
R
A
M
V
F
F
M
A
I
V
V
A
Y
V
P
E
G
L
L
A
T
V
T
V
C
L
S
L
T
A
K
R
L
A
S
K
N
C
V
V
K
N
L
E
A
V
E
T
L
G
S
T
S
V
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
S
H
L
W
F
D
N
H
I
H
S
A
DTTEDQSGQTFDQS---
S
-------------------
E
T
W
R
A
L
C
R
V
L
T
L
C
N
R
A
------
A
F
K
S
GQDAVPVPK
R
I
----------------
V
I
G
D
A
S
E
T
----------
A
L
L
K
F
S
E
L
T
L
G
N
A
M
G
Y
R
E
R
-------
F
P
KV
C
E
--
I
P
F
N
S
T
N
K
F
Q
------------------------
L
S
I
H
T
L
EDPR
D
----
P
R
H
V
L
V
M
K
G
A
P
E
R
V
---------
L
------
E
R
C
S
S
I
L
I
KGQE
L
P
L
D
E
Q
W
R
E
-
A
F
Q
T
A
Y
L
S
L
G
G
L
G
E
R
V
L
G
F
C
Q
L
Y
L
S
EKDYPPGYAFDVEAMNFPTS
G
L
S
F
---------------------
A
G
L
V
S
M
I
D
P
P
R
A
T
V
P
D
A
V
L
K
C
R
T
A
G
I
R
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
A
S
V
G
I
I
SEGS
E
T
V
E
D
I
A
ARLRVPVDQVNRKDAR
A
C
V
I
N
G
M
Q
L
K
D
MD
P
S
E
L
V
E
A
L
R
THPE
M
-----------------------------------------------------
V
F
A
R
T
S
P
Q
Q
K
L
V
I
V
E
S
C
Q
R
L
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
A
G
S
D
A
A
K
N
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
Q
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
K
N
I
P
E
L
T
P
Y
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
59.87
33%
-18
- C1 -
4UMV
2
?
A:
[126-730]
--------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
E
--------------
N
L
P
L
I
T
-
L
I
V
----
M
M
A
I
S
W
G
L
E
Q
F
N
H
P
F
G
Q
L
A
F
I
A
T
T
--
L
V
G
--
L
Y
P
I
A
R
Q
A
L
R
---------
L
I
K
S
G
S
--------
Y
F
A
-
I
------
E
T
L
M
S
V
A
A
I
G
-----
A
L
F
I
G
A
T
A
E
A
A
M
V
L
L
L
F
L
I
G
E
R
L
E
G
W
A
A
S
R
A
R
Q
G
V
S
A
L
M
A
L
K
P
E
T
A
T
R
L
R
-
N
G
E
R
E
E
V
A
I
N
S
L
R
P
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
S
P
F
-
A
S
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
A
T
G
----------
D
K
----------
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
I
D
R
I
L
K
L
I
E
E
A
E
E
R
R
A
P
I
E
R
F
I
D
R
F
S
R
I
Y
T
P
A
I
M
A
V
A
L
L
V
T
L
V
P
P
L
L
F
-
A
-
A
S
W
Q
E
W
I
Y
K
G
L
T
L
L
L
I
G
C
P
C
A
L
V
I
S
T
P
A
A
I
T
S
G
L
A
A
A
A
R
R
G
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
P
R
V
T
A
I
H
P
A
T
G
I
S
-------------------
E
-------------------
S
---
E
L
L
T
L
---
A
A
A
V
------
E
-------------
Q
----------------
G
A
T
H
P
L
A
Q
----------
A
I
V
R
E
A
Q
V
A
E
L
-------
A
-------
I
P
--
T
A
--
E
S
Q
R
A
L
V
G
S
G
------------------------
I
E
A
-
Q
V
----
N
----
G
--
E
R
V
L
I
C
A
A
G
K
H
---------
P
------
A
D
--------------------
A
F
A
G
L
I
N
E
L
E
S
A
G
Q
T
V
V
L
V
V
R
------------------------
N
D
D
V
---------------------
L
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
L
------------------------------------------------------
E
-----------------------------------------------------
F
K
A
G
L
L
P
E
D
K
V
K
A
V
T
K
L
N
Q
H
A
-
P
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
-
S
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
A
L
G
L
K
G
I
F
L
V
T
T
L
------
L
G
-------
M
-------
T
G
----
L
W
--------
L
A
V
L
A
D
T
G
A
T
V
L
V
T
A
N
A
L
R
L
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
56.37
27%
4
- C1 -
2ZXE
5
?
A:
[138-793]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
---
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
-
D
G
E
K
S
T
I
N
A
E
F
V
V
A
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
A
H
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
E
FSSENPLETR
N
I
----------
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
L
E
V
G
R
T
P
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
G
-
Y
--
S
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
F
D
N
Q
I
H
E
A
DTTENQSGAAFDKTS
A
T
W
-------------------
S
---
A
L
S
R
I
---
A
A
L
C
------
N
-------------
R
A
V
F
Q
A
GQDNVPILKRS
V
A
G
D
A
S
E
S
----------
A
L
L
K
C
I
E
L
C
C
G
-------
S
V
Q
G
M
R
D
R
N
P
--
K
I
V
E
I
P
F
N
S
T
N
-
K
Y
------------------------
Q
L
S
-
I
H
EN--
E
KSSE
S
R
Y
L
L
V
M
K
G
A
P
E
R
I
---------
L
------
D
R
C
S
T
I
LLNG
A
E
E
P
LK
E
D
M
K
E
-
A
F
Q
N
A
Y
L
E
L
G
G
L
G
E
R
V
L
G
F
C
H
F
ALPEDKYNEG
Y
P
F
D
ADEPNFPTT
D
L
C
F
---------------------
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
I
-----------------------------------------------------
S
EGNET
I
E
D
I
A
A
R
L
NIPIGQVNPRDAK
A
C
V
V
H
G
S
D
L
K
D
LS
T
E
V
L
D
D
I
L
H
Y
H
T
E
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
Fugue
54.72
21%
-9
- C1 -
3B8E
6
AT1A1_PIG
A:
[1-998]
------------------------------------------------------------------------
A
K
K
E
R
D
M
D
E
L
K
K
E
V
S
M
D
D
H
K
L
S
L
D
E
L
H
R
K
Y
G
T
D
L
S
R
G
L
T
P
A
R
A
A
E
I
L
A
R
D
G
P
N
A
L
T
P
P
P
T
T
P
E
W
V
K
F
C
R
----------------------------------------------------------------------------------
Q
L
F
-
G
G
F
S
M
L
L
W
I
G
A
I
L
C
F
L
A
Y
G
I
------------
Q
A
A
T
E
E
E
P
Q
-----
N
D
N
L
Y
L
G
V
---
V
L
S
A
V
V
I
I
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
K
I
M
E
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
-
N
G
E
K
M
S
I
N
A
E
E
V
V
V
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
A
N
G
C
K
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
S
P
D
----------
F
T
N
ENPLETRNI
A
F
F
S
T
N
C
V
E
G
T
A
R
G
I
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
L
E
G
G
Q
T
P
I
A
A
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
E
-
Y
T
--
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
M
T
V
A
H
M
W
S
D
N
Q
I
H
-------------------
E
A
DTTENQSGVSFDKTS
A
T
W
L
---
A
L
S
R
I
---
A
G
L
C
NR
A
V
F
Q
A
-------------
N
----------------
Q
E
N
L
P
I
L
K
R
A
V
A
GD
A
S
E
S
A
L
L
K
C
I
E
L
C
C
G
-------
S
-------
V
K
--
E
M
--
R
E
R
Y
T
K
I
V
E
I
PFNSTN
K
Y
Q
L
S
I
H
K
N
PNTAEPR
H
L
L
V
M
-
K
G
----
A
----
P
--
E
R
I
L
D
R
C
S
S
I
L
I
HGKEQPLD
E
------
E
L
K
D
A
F
--------------
Q
-
N
A
Y
L
E
L
G
G
L
G
E
R
V
L
G
F
C
H
L
F
L
------------------------
P
D
E
Q
FPEGF
Q
F
D
T
DDVNFPLDN
L
C
F
V
G
L
I
S
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
I
-----------------------------------------------------
S
EGN
E
T
V
E
D
IAARLNIPVSQVNPRDAK
A
C
V
V
H
G
S
D
L
K
D
MT
S
E
Q
L
D
D
I
L
K
YHTEI
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
S
K
K
A
D
I
G
V
A
M
G
I
A
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
T
L
T
S
N
I
P
E
I
T
P
F
L
------
I
F
-------
I
-------
I
A
NIPL
P
L
--------
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
E
Q
AESDIMKRQPRNPKTDKLVN
E
Q
L
I
S
M
A
YGQ
I
G
M
I
Q
A
L
G
G
F
F
T
Y
F
V
I
L
A
E
N
GFLPIHLL
G
L
R
V
N
WDDRWINDVEDSYG
Q
Q
W
T
Y
EQRKIVEFT
C
H
T
P
F
F
V
T
I
V
V
V
Q
W
A
D
L
V
I
C
KTRRNSVFQQGMKN
K
I
L
I
F
G
L
F
E
E
T
A
L
A
A
F
L
S
Y
CPGMGVA
L
R
M
Y
P
LKPTWWFCAFPY
S
L
L
I
F
V
Y
D
E
V
R
K
L
I
I
R
R
RPGGW
V
E
K
E
T
YY
59
HHSearch
49.68
38%
-110
- C1 -
3SKX
2
A:
[5-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
F
E
R
A
K
D
L
Q
A
V
I
F
D
K
T
G
T
L
T
E
G
R
F
G
V
T
D
I
V
G
F
N
-
H
S
-------------------
E
-------------------
D
---
E
L
L
Q
I
---
A
A
S
L
------
E
-------------
A
----------------
R
S
E
H
P
I
A
A
----------
A
I
V
E
E
A
E
K
R
G
F
-------
G
-------
L
T
--
E
V
--
E
E
F
R
A
I
P
G
K
G
------------------------
V
E
G
-
I
V
----
N
----
G
--
R
R
Y
M
V
V
S
P
G
Y
I
---------
R
------
E
L
G
I
K
------------------
T
D
E
S
V
E
K
L
K
Q
Q
G
K
T
V
V
F
I
L
K
------------------------
N
G
E
V
---------------------
S
G
V
I
A
L
A
D
R
I
R
P
E
S
R
E
A
I
S
K
L
K
A
I
G
I
K
C
M
M
L
T
G
D
N
R
F
V
A
K
W
V
A
E
E
L
G
L
D
-----------------------------------------------------
D
-----------------------------------------------------
Y
F
A
E
V
L
P
H
E
K
A
E
K
V
K
E
V
Q
Q
-
K
Y
V
T
A
M
V
G
D
G
V
N
D
A
P
A
L
A
Q
A
D
V
G
I
A
I
G
-
A
G
T
D
V
A
V
E
T
A
D
I
V
L
V
R
N
D
P
R
D
V
A
A
I
V
E
L
S
R
K
T
Y
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
48.15
39%
-106
- C1 -
3SKY
2
A:
[7-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
A
K
D
L
Q
A
V
I
F
D
K
T
G
T
L
T
E
G
R
F
G
V
T
D
I
V
G
F
N
H
S
E
-------------------
D
-----------------------
E
L
L
Q
I
---
A
A
S
L
------
E
-------------
A
----------------
R
S
E
H
P
I
A
A
----------
A
I
V
E
E
A
E
K
R
G
F
-------
G
-------
L
T
--
E
V
--
E
E
F
R
A
I
P
G
K
G
------------------------
V
E
G
-
I
V
----
N
----
G
--
R
R
Y
M
V
V
S
P
G
Y
I
---------
R
------
E
L
G
I
K
T
--------------
D
-
E
---
S
V
E
K
L
K
Q
Q
G
K
T
V
V
F
I
L
K
------------------------
N
G
E
V
---------------------
S
G
V
I
A
L
A
D
R
I
R
P
E
S
R
E
A
I
S
K
L
K
A
I
G
I
K
C
M
M
L
T
G
D
N
R
F
V
A
K
W
V
A
E
E
L
G
L
D
-----------------------------------------------------
D
-----------------------------------------------------
Y
F
A
E
V
L
P
H
E
K
A
E
K
V
K
E
V
Q
Q
K
-
Y
V
T
A
M
V
G
D
G
V
N
D
A
P
A
L
A
Q
A
D
V
G
I
A
I
G
-
A
G
T
D
V
A
V
E
T
A
D
I
V
L
V
R
N
D
P
R
D
V
A
A
I
V
E
L
S
R
K
T
Y
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------