@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu33900: (2016-07-27 )
MPYIVDVYAREVLDSRGNPTVEVEVYTETGAFGRALVPSGASTGEYEAVELRDGDKDRYLGKGVLTAVNNVNEIIAPELLGFDVTEQNAIDQLLIELDGTENKGKLGANAILGVSMACARAAADFLQIPLYQYLGGFNSKTLPVPMMNIVNGGEHADNNVDIQEFMIMPVGAPNFREALRMGAQIFHSLKSVLSAKGLNTAVGDEGGFAPNLGSNEEALQTIVEAIEKAGFKPGEEVKLAMDAASSEFYNKEDGKYHLSGEGVVKTSAEMVDWYEELVSKYPIISIEDGLDENDWEGHKLLTERLGKKVQLVGDDLFVTNTKKLSEGIKNGVGNSILIKVNQIGTLTETFDAIEMAKRAGYTAVISHRSGETEDSTIADIAVATNAGQIKTGAPSRTDRVAKYNQLLRIEDQLAETAQYHGINSFYNLNK
Atome Classification :
(49 SA)
.........10........20........30----------........40-........50........60........70........80-.--..--......90........100.......110.......120.......130.---..---..-----.-----.---140---........150.......160.......170.......180.......190....--.--..-200-.--.-------......210.......220.......230.......240.......250-----....---..------.----260------.--------.-......-----.270........280.......290.......300.......310......-.320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
P
Y
I
V
D
V
Y
A
R
E
V
L
DSRGN
P
T
V
E
V
E
V
Y
TETGA----------FGRALVPSGA-STGE
Y
E
A
V
E
LRDGDKDRYL
G
K
G
V
L
T
A
VN
N
V
N
E
I
I
A
P
E
LL--G--FD--VTEQN
A
I
D
Q
L
L
I
E
LDGTENKGKLG
A
N
A
I
L
G
V
S
M
A
C
A
R
A
A
A
D
F
L
Q
I
P
L
Y
Q
Y
---LG---GF-----N-----S---KT----LP
V
P
M
M
N
IVNGGEHADNNV
D
I
Q
E
F
M
I
MPVGAP
N
F
R
E
A
L
R
M
G
A
Q
I
F
H
S
L
K
S
V
L
S
AK--G--LN-TA--V--G-------DEGGFAPNLGS
N
E
E
A
L
Q
T
I
V
E
A
I
E
KAGFKPG
E
E
V
K
L
A
M
DAASSEFYNKE-----D
G
K
Y
---
H
L------S----G--------E--------
G
-
V
V
K
T
S
A
-----
E
M
V
-
D
W
Y
E
E
L
V
S
KY
P
I
I
S
IEDGLDENDWE
G
H
K
L
L
T
E
RLG
K
K
V
Q
LVGD
D
L
F
V-T
N
T
K
K
L
S
E
G
I
K
NGVG
N
S
I
L
I
K
VNQIG
T
L
T
E
T
F
D
A
I
E
M
A
K
RAG
Y
T
A
V
I
SHRSGETEDS
T
I
A
D
I
A
V
ATNAGQIKTGAPS
R
T
D
R
V
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
A
E
T
A
Q
YHG
I
N
S
FYNLNK-
21
PsiBlast_CBE
93.32
100%
-55
- C1 -
4A3R
3
ENO_BACSU
D:
[1-428]
M
P
Y
I
V
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
Y
T
E
T
G
A
----------
F
G
R
A
L
V
P
S
G
A
-
S
T
G
E
Y
E
A
V
E
L
R
D
G
D
K
D
R
Y
L
G
K
G
V
L
T
A
V
N
N
V
N
E
I
I
A
P
E
L
L
--
G
--
F
D
--
V
T
E
Q
N
A
I
D
Q
L
L
I
E
L
D
G
T
E
N
K
G
K
L
G
A
N
A
I
L
G
V
S
M
A
C
A
R
A
A
A
D
F
L
Q
I
P
L
Y
Q
Y
---
L
G
---
G
F
-----
N
-----
S
---
K
T
----
L
P
V
P
M
M
N
I
V
N
G
G
E
H
A
D
N
N
V
D
I
Q
E
F
M
I
M
P
V
G
A
P
N
F
R
E
A
L
R
M
G
A
Q
I
F
H
S
L
K
S
V
L
S
A
K
--
G
--
L
N
-
T
A
--
V
--
G
-------
D
E
G
G
F
A
P
N
L
G
S
N
E
E
A
L
Q
T
I
V
E
A
I
E
K
A
G
F
K
P
G
E
E
V
K
L
A
M
D
A
A
S
S
E
F
Y
N
K
E
-----
D
G
K
Y
---
H
L
------
S
----
G
--------
E
--------
G
-
V
V
K
T
S
A
-----
E
M
V
-
D
W
Y
E
E
L
V
S
K
Y
P
I
I
S
I
E
D
G
L
D
E
N
D
W
E
G
H
K
L
L
T
E
R
L
G
K
K
V
Q
L
V
G
D
D
L
F
V
-
T
N
T
K
K
L
S
E
G
I
K
N
G
V
G
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
D
A
I
E
M
A
K
R
A
G
Y
T
A
V
I
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
A
P
S
R
T
D
R
V
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
A
E
T
A
Q
Y
H
G
I
N
S
F
Y
N
L
---
1
PsiBlast_PDB
93.18
100%
-56
- C1 -
4A3R
-
ENO_BACSU
A:
[1-428]
M
P
Y
I
V
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
Y
T
E
T
G
A
----------
F
G
R
A
L
V
P
S
G
A
-
S
T
G
E
Y
E
A
V
E
L
R
D
G
D
K
D
R
Y
L
G
K
G
V
L
T
A
V
N
N
V
N
E
I
I
A
P
E
L
L
--
G
--
F
D
--
V
T
E
Q
N
A
I
D
Q
L
L
I
E
L
D
G
T
E
N
K
G
K
L
G
A
N
A
I
L
G
V
S
M
A
C
A
R
A
A
A
D
F
L
Q
I
P
L
Y
Q
Y
---
L
G
---
G
F
-----
N
-----
S
---
K
T
----
L
P
V
P
M
M
N
I
V
N
G
G
E
H
A
D
N
N
V
D
I
Q
E
F
M
I
M
P
V
G
A
P
N
F
R
E
A
L
R
M
G
A
Q
I
F
H
S
L
K
S
V
L
S
A
K
--
G
--
L
N
-
T
A
--
V
--
G
-------
D
E
G
G
F
A
P
N
L
G
S
N
E
E
A
L
Q
T
I
V
E
A
I
E
K
A
G
F
K
P
G
E
E
V
K
L
A
M
D
A
A
S
S
E
F
Y
N
K
E
-----
D
G
K
Y
---
H
L
------
S
----
G
--------
E
--------
G
-
V
V
K
T
S
A
-----
E
M
V
-
D
W
Y
E
E
L
V
S
K
Y
P
I
I
S
I
E
D
G
L
D
E
N
D
W
E
G
H
K
L
L
T
E
R
L
G
K
K
V
Q
L
V
G
D
D
L
F
V
-
T
N
T
K
K
L
S
E
G
I
K
N
G
V
G
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
D
A
I
E
M
A
K
R
A
G
Y
T
A
V
I
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
A
P
S
R
T
D
R
V
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
A
E
T
A
Q
Y
H
G
I
N
S
F
Y
N
L
---
16
PsiBlast_PDB
81.29
63%
-58
- C1 -
4ROP
6
ENO_SYNP6
A:
[9-421]
---
I
A
E
I
T
A
R
E
I
L
D
S
R
G
R
P
T
V
E
A
E
V
H
L
E
D
G
S
----------
V
G
L
A
Q
V
P
S
G
A
-
S
T
G
T
F
E
A
H
E
L
R
D
D
D
P
S
R
Y
G
G
K
G
V
Q
K
A
V
E
N
V
S
A
I
-
E
D
A
L
I
--
G
--
L
S
--
A
L
D
Q
E
G
L
D
K
A
M
I
A
L
D
G
T
P
N
K
K
N
L
G
A
N
A
I
L
A
V
S
L
A
T
A
H
A
A
A
T
S
L
N
L
P
L
Y
R
Y
---
L
G
---
G
P
-----
L
-----
A
---
N
V
----
L
P
V
P
M
M
N
V
I
N
G
G
A
H
A
D
N
N
V
D
F
Q
E
F
M
I
M
P
V
G
A
P
S
F
K
E
A
L
R
W
G
A
E
V
F
H
A
L
A
K
V
L
K
D
K
--
G
--
L
A
-
T
G
--
V
--
G
-------
D
E
G
G
F
A
P
N
L
G
S
N
K
E
A
L
E
L
L
L
T
A
I
E
A
A
G
Y
K
P
G
E
Q
V
A
L
A
M
D
V
A
S
S
E
F
Y
--
K
-----
N
G
L
Y
-----------
T
----
C
--------
D
--------
G
-
V
S
H
E
P
A
-----
G
M
I
-
G
I
L
A
D
L
V
S
Q
Y
P
I
V
S
I
E
D
G
L
Q
E
D
D
W
S
N
W
K
T
L
T
Q
Q
L
G
S
T
V
Q
L
V
G
D
D
L
F
V
-
T
N
P
D
R
L
Q
S
G
I
E
Q
G
V
G
N
A
V
L
I
K
L
N
Q
I
G
T
L
T
E
T
L
R
T
I
D
L
A
T
R
S
G
Y
R
S
V
I
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
T
R
A
G
Q
I
K
T
G
S
L
S
R
S
E
R
I
A
K
Y
N
R
L
L
R
I
E
A
A
L
G
E
N
A
L
Y
A
G
----------
25
PsiBlast_CBE
80.99
71%
-23
- C1 -
1W6T
2
ENO_STRPN
B:
[11-443]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
----
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
G
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
E
A
I
I
--
G
--
Y
D
--
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
I
P
L
Y
S
Y
---
L
G
---
G
F
-----
N
-----
T
---
K
V
----
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
L
P
V
G
A
P
T
F
K
E
A
L
R
Y
G
A
E
I
F
H
A
L
K
K
I
L
K
S
R
--
G
--
L
E
-
T
A
--
V
--
G
-------
D
E
G
G
F
A
P
R
F
E
G
T
E
D
G
V
E
T
I
L
A
A
I
E
A
A
G
Y
V
P
G
K
D
V
F
L
G
F
D
C
A
S
S
E
F
Y
D
K
E
-----
R
K
V
Y
DYT
K
F
------
E
----
G
--------
E
--------
G
A
A
V
R
T
S
A
-----
E
Q
I
-
D
Y
L
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
A
L
T
E
R
L
G
K
K
V
Q
L
V
G
D
D
F
F
V
-
T
N
T
D
Y
L
A
R
G
I
Q
E
G
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
E
Y
R
G
L
K
S
F
Y
N
L
K
--
46
PsiBlast_CBE
80.90
61%
-59
- C1 -
3UJ2
3
?
E:
[28-449]
---
I
E
K
V
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
Y
L
A
G
G
V
----------
T
G
R
G
T
A
P
S
G
----
G
E
F
E
A
L
E
L
R
D
G
D
K
G
R
F
G
G
K
G
V
T
K
A
V
Q
N
I
N
T
E
I
S
E
I
L
S
--
G
--
M
D
--
A
S
D
I
Y
A
V
D
R
A
M
I
D
A
D
G
T
K
D
K
S
K
F
G
A
N
A
V
L
A
V
S
I
A
C
A
K
A
A
A
A
A
L
G
V
P
L
Y
R
F
---
L
G
---
G
L
-----
N
-----
A
---
N
R
----
L
P
V
P
M
M
N
I
L
N
G
G
A
H
A
A
N
T
V
D
V
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
A
L
R
Q
C
T
E
V
F
H
A
L
A
G
L
L
K
S
K
--
G
--
L
A
-
T
S
--
V
--
G
-------
D
E
G
G
F
A
P
D
L
A
S
D
E
E
A
I
E
Y
I
L
E
A
V
K
L
A
G
Y
E
P
G
R
D
F
V
L
A
M
D
A
A
S
S
E
W
K
G
E
K
-----
K
G
E
Y
---
I
L
------
P
----
K
--------
C
--------
K
-
R
K
F
A
S
E
-----
E
L
V
-
A
H
W
K
S
L
C
E
R
Y
P
I
V
S
I
E
D
G
L
D
E
E
D
W
E
G
W
Q
Y
M
T
R
E
L
G
D
K
I
Q
L
V
G
D
D
L
F
V
-
T
N
T
E
R
L
N
K
G
I
K
E
R
C
G
N
S
I
L
I
K
L
N
Q
I
G
T
V
S
E
T
L
E
A
I
K
M
A
H
K
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
L
N
T
G
Q
I
K
T
G
A
P
S
R
S
E
R
V
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
D
S
A
V
Y
P
G
F
T
T
F
------
48
PsiBlast_CBE
80.89
61%
-60
- C1 -
3UJ2
5
?
C:
[28-449]
---
I
E
K
V
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
Y
L
A
G
G
V
----------
T
G
R
G
T
A
P
S
G
----
G
E
F
E
A
L
E
L
R
D
G
D
K
G
R
F
G
G
K
G
V
T
K
A
V
Q
N
I
N
T
E
I
S
E
I
L
S
--
G
--
M
D
--
A
S
D
I
Y
A
V
D
R
A
M
I
D
A
D
G
T
K
D
K
S
K
F
G
A
N
A
V
L
A
V
S
I
A
C
A
K
A
A
A
A
A
L
G
V
P
L
Y
R
F
---
L
G
---
G
L
-----
N
-----
A
---
N
R
----
L
P
V
P
M
M
N
I
L
N
G
G
A
H
A
A
N
T
V
D
V
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
A
L
R
Q
C
T
E
V
F
H
A
L
A
G
L
L
K
S
K
--
G
--
L
A
-
T
S
--
V
--
G
-------
D
E
G
G
F
A
P
D
L
A
S
D
E
E
A
I
E
Y
I
L
E
A
V
K
L
A
G
Y
E
P
G
R
D
F
V
L
A
M
D
A
A
S
S
E
W
K
G
E
K
-----
K
G
E
Y
---
I
L
------
P
----
K
--------
C
--------
K
-
R
K
F
A
S
E
-----
E
L
V
-
A
H
W
K
S
L
C
E
R
Y
P
I
V
S
I
E
D
G
L
D
E
E
D
W
E
G
W
Q
Y
M
T
R
E
L
G
D
K
I
Q
L
V
G
D
D
L
F
V
-
T
N
T
E
R
L
N
K
G
I
K
E
R
C
G
N
S
I
L
I
K
L
N
Q
I
G
T
V
S
E
T
L
E
A
I
K
M
A
H
K
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
L
N
T
G
Q
I
K
T
G
A
P
S
R
S
E
R
V
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
D
S
A
V
Y
P
G
F
T
T
F
------
17
PsiBlast_PDB
80.78
61%
-60
- C1 -
3UJ2
5
?
A:
[28-449]
---
I
E
K
V
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
Y
L
A
G
G
V
----------
T
G
R
G
T
A
P
S
G
----
G
E
F
E
A
L
E
L
R
D
G
D
K
G
R
F
G
G
K
G
V
T
K
A
V
Q
N
I
N
T
E
I
S
E
I
L
S
--
G
--
M
D
--
A
S
D
I
Y
A
V
D
R
A
M
I
D
A
D
G
T
K
D
K
S
K
F
G
A
N
A
V
L
A
V
S
I
A
C
A
K
A
A
A
A
A
L
G
V
P
L
Y
R
F
---
L
G
---
G
L
-----
N
-----
A
---
N
R
----
L
P
V
P
M
M
N
I
L
N
G
G
A
H
A
A
N
T
V
D
V
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
A
L
R
Q
C
T
E
V
F
H
A
L
A
G
L
L
K
S
K
--
G
--
L
A
-
T
S
--
V
--
G
-------
D
E
G
G
F
A
P
D
L
A
S
D
E
E
A
I
E
Y
I
L
E
A
V
K
L
A
G
Y
E
P
G
R
D
F
V
L
A
M
D
A
A
S
S
E
W
K
G
E
K
-----
K
G
E
Y
---
I
L
------
P
----
K
--------
C
--------
K
-
R
K
F
A
S
E
-----
E
L
V
-
A
H
W
K
S
L
C
E
R
Y
P
I
V
S
I
E
D
G
L
D
E
E
D
W
E
G
W
Q
Y
M
T
R
E
L
G
D
K
I
Q
L
V
G
D
D
L
F
V
-
T
N
T
E
R
L
N
K
G
I
K
E
R
C
G
N
S
I
L
I
K
L
N
Q
I
G
T
V
S
E
T
L
E
A
I
K
M
A
H
K
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
L
N
T
G
Q
I
K
T
G
A
P
S
R
S
E
R
V
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
D
S
A
V
Y
P
G
F
T
T
F
------
44
PsiBlast_CBE
80.75
61%
-59
- C1 -
3UJ2
6
?
G:
[28-449]
---
I
E
K
V
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
Y
L
A
G
G
V
----------
T
G
R
G
T
A
P
S
G
----
G
E
F
E
A
L
E
L
R
D
G
D
K
G
R
F
G
G
K
G
V
T
K
A
V
Q
N
I
N
T
E
I
S
E
I
L
S
--
G
--
M
D
--
A
S
D
I
Y
A
V
D
R
A
M
I
D
A
D
G
T
K
D
K
S
K
F
G
A
N
A
V
L
A
V
S
I
A
C
A
K
A
A
A
A
A
L
G
V
P
L
Y
R
F
---
L
G
---
G
L
-----
N
-----
A
---
N
R
----
L
P
V
P
M
M
N
I
L
N
G
G
A
H
A
A
N
T
V
D
V
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
A
L
R
Q
C
T
E
V
F
H
A
L
A
G
L
L
K
S
K
--
G
--
L
A
-
T
S
--
V
--
G
-------
D
E
G
G
F
A
P
D
L
A
S
D
E
E
A
I
E
Y
I
L
E
A
V
K
L
A
G
Y
E
P
G
R
D
F
V
L
A
M
D
A
A
S
S
E
W
K
G
E
K
-----
K
G
E
Y
---
I
L
------
P
----
K
--------
C
--------
K
-
R
K
F
A
S
E
-----
E
L
V
-
A
H
W
K
S
L
C
E
R
Y
P
I
V
S
I
E
D
G
L
D
E
E
D
W
E
G
W
Q
Y
M
T
R
E
L
G
D
K
I
Q
L
V
G
D
D
L
F
V
-
T
N
T
E
R
L
N
K
G
I
K
E
R
C
G
N
S
I
L
I
K
L
N
Q
I
G
T
V
S
E
T
L
E
A
I
K
M
A
H
K
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
L
N
T
G
Q
I
K
T
G
A
P
S
R
S
E
R
V
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
D
S
A
V
Y
P
G
F
T
T
F
------
52
PsiBlast_CBE
80.57
57%
-62
- C1 -
3QN3
4
ENO_CAMJE
B:
[4-414]
M
L
V
I
E
D
V
R
A
Y
E
V
L
D
S
R
G
N
P
T
V
K
A
E
V
T
L
S
D
G
S
----------
V
G
A
A
I
V
P
S
G
A
-
S
T
G
S
K
E
A
L
E
L
R
D
N
D
-
E
R
F
G
G
K
G
V
L
K
A
V
A
N
V
N
E
T
I
A
D
E
I
L
--
G
--
L
D
--
A
F
N
Q
T
Q
L
D
D
T
L
R
E
L
D
G
T
N
N
Y
S
N
L
G
A
N
A
T
L
G
V
S
M
A
T
A
R
A
A
A
A
A
L
G
M
P
L
Y
R
Y
---
L
G
---
G
A
-----
N
-----
A
---
S
I
----
L
P
V
P
M
C
N
I
I
N
G
G
A
H
A
N
N
N
V
D
F
Q
E
F
M
I
M
P
F
G
F
T
S
F
K
E
A
L
R
S
V
C
E
I
Y
A
I
L
K
K
E
L
A
N
S
--
G
--
H
S
-
T
A
--
L
--
G
-------
D
E
G
G
F
A
P
N
L
A
N
N
T
E
P
I
D
L
L
M
T
C
I
K
K
A
G
Y
E
--
N
R
V
K
I
A
L
D
V
A
S
T
E
F
F
--
K
-----
D
G
K
Y
---
H
M
------
E
----
G
--------
K
--------
A
-
F
--
S
S
E
-----
A
L
I
-
E
R
Y
V
E
L
C
A
K
Y
P
I
C
S
I
E
D
G
L
A
E
N
D
F
E
G
W
I
K
L
T
E
K
L
G
N
K
I
Q
L
V
G
D
D
L
F
V
-
T
N
E
D
I
L
R
E
G
I
I
K
K
M
A
N
A
V
L
I
K
P
N
Q
I
G
T
I
T
Q
T
M
R
T
V
R
L
A
Q
R
N
N
Y
K
C
V
M
S
H
R
S
G
E
S
E
D
A
F
I
A
D
F
A
V
A
L
N
T
G
Q
I
K
T
G
A
L
A
R
G
E
R
T
A
K
Y
N
R
L
L
E
I
E
---
F
E
S
D
E
Y
L
G
----------
47
PsiBlast_CBE
80.57
61%
-58
- C1 -
3UJ2
4
?
D:
[28-449]
---
I
E
K
V
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
Y
L
A
G
G
V
----------
T
G
R
G
T
A
P
S
G
----
G
E
F
E
A
L
E
L
R
D
G
D
K
G
R
F
G
G
K
G
V
T
K
A
V
Q
N
I
N
T
E
I
S
E
I
L
S
--
G
--
M
D
--
A
S
D
I
Y
A
V
D
R
A
M
I
D
A
D
G
T
K
D
K
S
K
F
G
A
N
A
V
L
A
V
S
I
A
C
A
K
A
A
A
A
A
L
G
V
P
L
Y
R
F
---
L
G
---
G
L
-----
N
-----
A
---
N
R
----
L
P
V
P
M
M
N
I
L
N
G
G
A
H
A
A
N
T
V
D
V
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
A
L
R
Q
C
T
E
V
F
H
A
L
A
G
L
L
K
S
K
--
G
--
L
A
-
T
S
--
V
--
G
-------
D
E
G
G
F
A
P
D
L
A
S
D
E
E
A
I
E
Y
I
L
E
A
V
K
L
A
G
Y
E
P
G
R
D
F
V
L
A
M
D
A
A
S
S
E
W
K
G
E
K
-----
K
G
E
Y
---
I
L
------
P
----
K
--------
C
--------
K
-
R
K
F
A
S
E
-----
E
L
V
-
A
H
W
K
S
L
C
E
R
Y
P
I
V
S
I
E
D
G
L
D
E
E
D
W
E
G
W
Q
Y
M
T
R
E
L
G
D
K
I
Q
L
V
G
D
D
L
F
V
-
T
N
T
E
R
L
N
K
G
I
K
E
R
C
G
N
S
I
L
I
K
L
N
Q
I
G
T
V
S
E
T
L
E
A
I
K
M
A
H
K
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
L
N
T
G
Q
I
K
T
G
A
P
S
R
S
E
R
V
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
D
S
A
V
Y
P
G
F
T
T
F
------
35
PsiBlast_CBE
80.47
64%
-86
- C1 -
4YWS
1
ENO_CHLAA
B:
[8-424]
------
I
V
A
R
E
V
L
D
S
R
G
N
P
T
I
E
V
D
V
R
L
E
S
G
D
----------
V
G
R
A
I
V
P
S
G
-----------
L
R
D
G
D
K
S
R
Y
N
G
K
G
V
L
K
A
V
Q
A
V
N
E
D
I
A
E
A
L
I
--
G
--
F
D
--
A
A
D
Q
I
A
L
D
Q
E
L
I
A
L
D
G
T
P
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
A
K
A
A
A
A
A
F
G
L
P
L
Y
R
Y
---
L
G
---
G
V
-----
Y
-----
A
---
H
V
----
L
P
V
P
M
M
N
I
M
N
G
G
Q
H
A
T
---
D
F
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
G
L
R
W
G
A
E
I
Y
H
M
L
K
K
V
I
H
D
R
------------------------
E
G
G
F
A
P
S
L
-
T
N
D
A
P
L
Q
L
I
M
E
A
I
E
K
A
G
Y
R
P
G
E
Q
I
V
I
A
L
D
P
A
T
T
E
I
F
-----------
Y
---
H
L
------
K
-------------
E
--------
G
-
R
--
S
S
A
-----
E
M
V
-
D
Y
W
V
D
L
V
N
R
Y
P
I
I
S
L
E
D
G
L
A
E
D
D
W
E
G
W
A
L
L
-
A
K
L
G
D
R
V
Q
L
V
G
D
D
F
L
V
-
T
N
V
Q
R
L
Q
R
A
I
E
A
K
A
A
N
S
I
L
I
K
L
N
Q
I
G
S
L
T
E
T
L
S
A
I
Q
L
A
Q
R
S
G
W
T
A
V
V
S
H
R
S
G
-
S
E
D
V
T
I
A
D
L
V
V
A
T
N
A
G
Q
I
K
T
G
A
P
A
-
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
S
A
A
R
Y
A
G
R
S
A
F
------
5
PsiBlast_PDB
80.17
71%
-21
- C1 -
1W6T
2
ENO_STRPN
A:
[11-443]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
----
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
G
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
E
A
I
I
--
G
--
Y
D
--
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
I
P
L
Y
S
Y
---
L
G
---
G
F
-----
N
-----
T
---
K
V
----
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
L
P
V
G
A
P
T
F
K
E
A
L
R
Y
G
A
E
I
F
H
A
L
K
K
I
L
K
S
R
--
G
--
L
E
-
T
A
--
V
--
G
-------
D
E
G
G
F
A
P
R
F
E
G
T
E
D
G
V
E
T
I
L
A
A
I
E
A
A
G
Y
V
P
G
K
D
V
F
L
G
F
D
C
A
S
S
E
F
Y
D
-------
R
K
V
Y
DYT
K
F
------
E
----
G
--------
E
--------
G
A
A
V
R
T
S
A
-----
E
Q
I
-
D
Y
L
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
A
L
T
E
R
L
G
K
K
V
Q
L
V
G
D
D
F
F
V
-
T
N
T
D
Y
L
A
R
G
I
Q
E
G
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
E
Y
R
G
L
K
S
F
Y
N
L
K
--
10
PsiBlast_PDB
80.16
69%
-60
- C1 -
4MKS
2
ENO2_LACGA
A:
[3-428]
--
V
I
T
D
I
H
A
R
E
V
L
D
S
R
G
N
P
T
A
E
A
E
V
Y
T
E
L
G
G
----------
F
G
R
A
I
V
P
S
G
A
-
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
F
G
G
Q
G
V
L
T
A
V
E
N
V
N
G
E
I
A
K
A
V
I
--
G
--
L
D
--
V
T
D
Q
R
L
I
D
Q
T
M
I
D
L
D
G
T
P
N
K
G
R
L
G
A
N
A
I
L
S
V
S
L
A
S
A
R
A
A
A
D
E
L
G
L
P
L
Y
E
Y
---
L
G
---
G
P
-----
N
-----
A
---
H
V
----
L
P
T
P
M
M
N
V
I
N
G
G
---
D
N
N
V
D
I
Q
E
F
M
I
M
P
V
G
A
K
S
L
H
E
A
V
R
M
G
A
E
T
F
H
T
L
K
G
L
L
Q
E
R
--
G
--
E
S
-
T
A
--
V
--
G
-------
D
E
G
G
F
A
P
---
N
N
E
E
P
F
E
I
L
V
E
A
I
Q
R
A
G
Y
K
P
G
Q
D
I
A
I
A
F
D
C
A
A
S
E
F
Y
------------------------------------------------------------
W
T
-
S
L
I
E
D
L
V
D
K
Y
P
V
I
S
V
E
D
P
L
D
E
N
D
W
E
G
W
K
T
F
T
E
R
L
G
D
K
V
Q
I
V
G
D
D
L
F
V
-
T
N
T
S
Y
L
E
K
G
I
K
M
G
V
A
N
S
I
L
I
K
L
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
V
V
A
T
N
A
G
Q
I
K
T
G
S
M
S
R
T
D
R
I
A
K
Y
N
Q
L
M
R
I
E
E
A
L
G
S
T
A
Q
Y
K
G
I
H
S
F
Y
N
L
---
45
PsiBlast_CBE
80.13
61%
-60
- C1 -
3UJ2
1
?
F:
[28-449]
---
I
E
K
V
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
Y
L
A
G
G
V
----------
T
G
R
G
T
A
P
S
G
----
G
E
F
E
A
L
E
L
R
D
G
D
K
G
R
F
G
G
K
G
V
T
K
A
V
Q
N
I
N
T
E
I
S
E
I
L
S
--
G
--
M
D
--
A
S
D
I
Y
A
V
D
R
A
M
I
D
A
D
G
T
K
D
K
S
K
F
G
A
N
A
V
L
A
V
S
I
A
C
A
K
A
A
A
A
A
L
G
V
P
L
Y
R
F
---
L
G
---
G
L
-----
N
-----
A
---
N
R
----
L
P
V
P
M
M
N
I
L
N
G
G
A
H
A
A
N
T
V
D
V
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
A
L
R
Q
C
T
E
V
F
H
A
L
A
G
L
L
K
S
K
--
G
--
L
A
-
T
S
--
V
--
G
-------
D
E
G
G
F
A
P
D
L
A
S
D
E
E
A
I
E
Y
I
L
E
A
V
K
L
A
G
Y
E
P
G
R
D
F
V
L
A
M
D
A
A
S
S
E
W
K
G
E
K
-----
K
G
E
Y
---
I
L
------
P
----
K
--------
C
--------
K
-
R
K
F
A
S
E
-----
E
L
V
-
A
H
W
K
S
L
C
E
R
Y
P
I
V
S
I
E
D
G
L
D
E
E
D
W
E
G
W
Q
Y
M
T
R
E
L
G
D
K
I
Q
L
V
G
D
D
L
F
V
-
T
N
T
E
R
L
N
K
G
I
K
E
R
C
G
N
S
I
L
I
K
L
N
Q
I
G
T
V
S
E
T
L
E
A
I
K
M
A
H
K
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
L
N
T
G
Q
I
K
T
G
A
P
S
R
S
E
R
V
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
D
S
A
V
Y
P
G
F
T
T
F
------
51
PsiBlast_CBE
79.93
57%
-62
- C1 -
3QN3
5
ENO_CAMJE
C:
[4-414]
M
L
V
I
E
D
V
R
A
Y
E
V
L
D
S
R
G
N
P
T
V
K
A
E
V
T
L
S
D
G
S
----------
V
G
A
A
I
V
P
S
G
A
-
S
T
G
S
K
E
A
L
E
L
R
D
N
D
-
E
R
F
G
G
K
G
V
L
K
A
V
A
N
V
N
E
T
I
A
D
E
I
L
--
G
--
L
D
--
A
F
N
Q
T
Q
L
D
D
T
L
R
E
L
D
G
T
N
N
Y
S
N
L
G
A
N
A
T
L
G
V
S
M
A
T
A
R
A
A
A
A
A
L
G
M
P
L
Y
R
Y
---
L
G
---
G
A
-----
N
-----
A
---
S
I
----
L
P
V
P
M
C
N
I
I
N
G
G
A
H
A
N
N
N
V
D
F
Q
E
F
M
I
M
P
F
G
F
T
S
F
K
E
A
L
R
S
V
C
E
I
Y
A
I
L
K
K
E
L
A
N
S
--
G
--
H
S
-
T
A
--
L
--
G
-------
D
E
G
G
F
A
P
N
L
A
N
N
T
E
P
I
D
L
L
M
T
C
I
K
K
A
G
Y
E
--
N
R
V
K
I
A
L
D
V
A
S
T
E
F
F
--
K
-----
D
G
K
Y
---
H
M
------
E
----
G
--------
K
--------
A
-
F
--
S
S
E
-----
A
L
I
-
E
R
Y
V
E
L
C
A
K
Y
P
I
C
S
I
E
D
G
L
A
E
N
D
F
E
G
W
I
K
L
T
E
K
L
G
N
K
I
Q
L
V
G
D
D
L
F
V
-
T
N
E
D
I
L
R
E
G
I
I
K
K
M
A
N
A
V
L
I
K
P
N
Q
I
G
T
I
T
Q
T
M
R
T
V
R
L
A
Q
R
N
N
Y
K
C
V
M
S
H
R
S
G
E
S
E
D
A
F
I
A
D
F
A
V
A
L
N
T
G
Q
I
K
T
G
A
L
A
R
G
E
R
T
A
K
Y
N
R
L
L
E
I
E
---
F
E
S
D
E
Y
L
G
----------
12
PsiBlast_PDB
79.83
64%
-65
- C1 -
4Z1Y
1
ENO_CHLAA
A:
[8-424]
------
I
V
A
R
E
V
L
D
S
R
G
N
P
T
I
E
V
D
V
R
L
E
S
G
D
----------
V
G
R
A
I
V
P
S
G
A
-
S
T
G
A
H
E
A
L
E
L
R
D
G
D
K
S
R
Y
N
G
K
G
V
L
K
A
V
Q
A
V
N
E
D
I
A
E
A
L
I
--
G
--
F
D
--
A
A
D
Q
I
A
L
D
Q
E
L
I
A
L
D
G
T
P
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
A
K
A
A
A
A
A
F
G
L
P
L
Y
R
Y
---
L
G
---
G
V
-----
Y
-----
A
---
H
V
----
L
P
V
P
M
M
N
I
M
N
G
G
Q
H
A
T
N
S
T
D
F
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
G
L
R
W
G
A
E
I
Y
H
M
L
K
K
V
I
H
D
R
--
G
--
F
S
-
T
T
--
V
--
G
-------
D
E
G
G
F
A
P
S
L
P
T
N
D
A
P
L
Q
L
I
M
E
A
I
E
K
A
G
Y
R
P
G
E
Q
I
V
I
A
L
D
P
A
T
T
E
I
F
--------
D
G
K
Y
---
H
L
------
K
----
R
--------
E
--------
G
-
R
S
L
S
S
A
-----
E
M
V
-
D
Y
W
V
D
L
V
N
R
Y
P
I
I
S
L
E
D
G
L
A
E
D
D
W
E
G
W
A
L
L
R
A
K
L
G
D
R
V
Q
L
V
G
D
D
F
L
V
-
T
N
V
Q
R
L
Q
R
A
I
E
A
K
A
A
N
S
I
L
I
K
L
N
Q
I
G
S
L
T
E
T
L
S
A
I
Q
L
A
Q
R
S
G
W
T
A
V
V
S
H
R
S
G
E
S
E
D
V
T
I
A
D
L
V
V
A
T
N
A
G
Q
I
K
T
G
A
P
A
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
S
A
A
R
Y
A
G
R
S
A
F
------
11
PsiBlast_PDB
79.79
64%
-65
- C1 -
4Z17
3
ENO_CHLAA
A:
[8-424]
------
I
V
A
R
E
V
L
D
S
R
G
N
P
T
I
E
V
D
V
R
L
E
S
G
D
----------
V
G
R
A
I
V
P
S
G
A
-
S
T
G
A
H
E
A
L
E
L
R
D
G
D
K
S
R
Y
N
G
K
G
V
L
K
A
V
Q
A
V
N
E
D
I
A
E
A
L
I
--
G
--
F
D
--
A
A
D
Q
I
A
L
D
Q
E
L
I
A
L
D
G
T
P
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
A
K
A
A
A
A
A
F
G
L
P
L
Y
R
Y
---
L
G
---
G
V
-----
Y
-----
A
---
H
V
----
L
P
V
P
M
M
N
I
M
N
G
G
Q
H
--
N
S
T
D
F
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
G
L
R
W
G
A
E
I
Y
H
M
L
K
K
V
I
H
D
R
--
G
--
F
S
-
T
T
--
V
--
G
-------
D
E
G
G
F
A
P
S
L
P
T
N
D
A
P
L
Q
L
I
M
E
A
I
E
K
A
G
Y
R
P
G
E
Q
I
V
I
A
L
D
P
A
T
T
E
I
F
--
E
-----
D
G
K
Y
---
H
L
------
K
----
R
--------
E
--------
G
-
R
S
L
S
S
A
-----
E
M
V
-
D
Y
W
V
D
L
V
N
R
Y
P
I
I
S
L
E
D
G
L
A
E
D
D
W
E
G
W
A
L
L
R
A
K
L
G
D
R
V
Q
L
V
G
D
D
F
L
V
-
T
N
V
Q
R
L
Q
R
A
I
E
A
K
A
A
N
S
I
L
I
K
L
N
Q
I
G
S
L
T
E
T
L
S
A
I
Q
L
A
Q
R
S
G
W
T
A
V
V
S
H
R
S
G
E
S
E
D
V
T
I
A
D
L
V
V
A
T
N
A
G
Q
I
K
T
G
A
P
A
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
S
A
A
R
Y
A
G
R
S
A
F
------
49
PsiBlast_CBE
79.64
61%
-57
- C1 -
3UJ2
6
?
B:
[28-449]
---
I
E
K
V
I
G
R
E
I
I
D
S
R
G
N
P
T
V
E
A
E
V
Y
L
A
G
G
V
----------
T
G
R
G
T
A
P
S
G
----
G
E
F
E
A
L
E
L
R
D
G
D
K
G
R
F
G
G
K
G
V
T
K
A
V
Q
N
I
N
T
E
I
S
E
I
L
S
--
G
--
M
D
--
A
S
D
I
Y
A
V
D
R
A
M
I
D
A
D
G
T
K
D
K
S
K
F
G
A
N
A
V
L
A
V
S
I
A
C
A
K
A
A
A
A
A
L
G
V
P
L
Y
R
F
---
L
G
---
G
L
-----
N
-----
A
---
N
R
----
L
P
V
P
M
M
N
I
L
N
G
G
A
H
A
A
N
T
V
D
V
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
A
L
R
Q
C
T
E
V
F
H
A
L
A
G
L
L
K
S
K
--
G
--
L
A
-
T
S
--
V
--
G
-------
D
E
G
G
F
A
P
D
L
A
S
D
E
E
A
I
E
Y
I
L
E
A
V
K
L
A
G
Y
E
P
G
R
D
F
V
L
A
M
D
A
A
S
S
E
W
K
G
E
K
-----
K
G
E
Y
---
I
L
------
P
----
K
--------
C
--------
K
-
R
K
F
A
S
E
-----
E
L
V
-
A
H
W
K
S
L
C
E
R
Y
P
I
V
S
I
E
D
G
L
D
E
E
D
W
E
G
W
Q
Y
M
T
R
E
L
G
D
K
I
Q
L
V
G
D
D
L
F
V
-
T
N
T
E
R
L
N
K
G
I
K
E
R
C
G
N
S
I
L
I
K
L
N
Q
I
G
T
V
S
E
T
L
E
A
I
K
M
A
H
K
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
L
N
T
G
Q
I
K
T
G
A
P
S
R
S
E
R
V
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
D
S
A
V
Y
P
G
F
T
T
F
------
32
PsiBlast_CBE
79.60
69%
-62
- C1 -
4MKS
1
ENO2_LACGA
B:
[3-428]
--
V
I
T
D
I
H
A
R
E
V
L
D
S
R
G
N
P
T
A
E
A
E
V
Y
T
E
L
G
G
----------
F
G
R
A
I
V
P
S
G
A
-
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
F
G
G
Q
G
V
L
T
A
V
E
N
V
N
G
E
I
A
K
A
V
I
--
G
--
L
D
--
V
T
D
Q
R
L
I
D
Q
T
M
I
D
L
D
G
T
P
N
K
G
R
L
G
A
N
A
I
L
S
V
S
L
A
S
A
R
A
A
A
D
E
L
G
L
P
L
Y
E
Y
---
L
G
---
G
P
-----
N
-----
A
---
H
V
----
L
P
T
P
M
M
N
V
I
N
G
------
N
V
D
I
Q
E
F
M
I
M
P
V
G
A
K
S
L
H
E
A
V
R
M
G
A
E
T
F
H
T
L
K
G
L
L
Q
E
R
--
G
--
E
S
-
T
A
--
V
--
G
-------
D
E
G
G
F
A
P
---
N
N
E
E
P
F
E
I
L
V
E
A
I
Q
R
A
G
Y
K
P
G
Q
D
I
A
I
A
F
D
C
A
A
S
E
F
Y
------------------------------------------------------------
W
T
-
S
L
I
E
D
L
V
D
K
Y
P
V
I
S
V
E
D
P
L
D
E
N
D
W
E
G
W
K
T
F
T
E
R
L
G
D
K
V
Q
I
V
G
D
D
L
F
V
-
T
N
T
S
Y
L
E
K
G
I
K
M
G
V
A
N
S
I
L
I
K
L
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
V
V
A
T
N
A
G
Q
I
K
T
G
S
M
S
R
T
D
R
I
A
K
Y
N
Q
L
M
R
I
E
E
A
L
G
S
T
A
Q
Y
K
G
I
H
S
F
Y
N
L
---
123
HHSearch
79.41
63%
-50
* C1 *
4ROP
6
ENO_SYNP6
A:
[6-422]
G
T
Q
I
A
E
I
T
A
R
E
I
L
D
S
R
G
R
P
T
V
E
A
E
V
H
L
E
D
G
S
----------
V
G
L
A
Q
V
P
S
G
A
-
S
T
G
T
F
E
A
H
E
L
R
D
D
D
P
S
R
Y
G
G
K
G
V
Q
K
A
V
E
N
V
S
-
A
I
E
D
A
L
I
--
G
--
L
S
--
A
L
D
Q
E
G
L
D
K
A
M
I
A
L
D
G
T
P
N
K
K
N
L
G
A
N
A
I
L
A
V
S
L
A
T
A
H
A
A
A
T
S
L
N
L
P
L
Y
R
Y
---
L
G
---
G
P
-----
L
-----
A
---
N
V
----
L
P
V
P
M
M
N
V
I
N
G
G
A
H
A
D
N
N
V
D
F
Q
E
F
M
I
M
P
V
G
A
P
S
F
K
E
A
L
R
W
G
A
E
V
F
H
A
L
A
K
V
L
K
D
K
--
G
--
L
A
-
T
G
--
V
--
G
-------
D
E
G
G
F
A
P
N
L
G
S
N
K
E
A
L
E
L
L
L
T
A
I
E
A
A
G
Y
K
P
G
E
Q
V
A
L
A
M
D
V
A
S
S
E
F
Y
K
-------
N
G
L
Y
---
T
C
------
D
----------------------
G
-
V
S
H
E
P
A
-----
G
M
I
-
G
I
L
A
D
L
V
S
Q
Y
P
I
V
S
I
E
D
G
L
Q
E
D
D
W
S
N
W
K
T
L
T
Q
Q
L
G
S
T
V
Q
L
V
G
D
D
L
-
F
V
T
N
P
D
R
L
Q
S
G
I
E
Q
G
V
G
N
A
V
L
I
K
L
N
Q
I
G
T
L
T
E
T
L
R
T
I
D
L
A
T
R
S
G
Y
R
S
V
I
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
T
R
A
G
Q
I
K
T
G
S
L
S
R
S
E
R
I
A
K
Y
N
R
L
L
R
I
E
A
A
L
G
E
N
A
L
Y
A
G
A
---------
34
PsiBlast_CBE
77.65
64%
-67
- C1 -
4Z17
3
ENO_CHLAA
B:
[8-424]
------
I
V
A
R
E
V
L
D
S
R
G
N
P
T
I
E
V
D
V
R
L
E
S
G
D
----------
V
G
R
A
I
V
P
S
G
A
-
S
T
G
A
H
E
A
L
E
L
R
D
G
D
K
S
R
Y
N
G
K
G
V
L
K
A
V
Q
A
V
N
E
D
I
A
E
A
L
I
--
G
--
F
D
--
A
A
D
Q
I
A
L
D
Q
E
L
I
A
L
D
G
T
P
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
A
K
A
A
A
A
A
F
G
L
P
L
Y
R
Y
---
L
G
---
G
V
-----
Y
-----
A
---
H
V
----
L
P
V
P
M
M
N
I
M
N
G
G
Q
H
A
-----
F
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
G
L
R
W
G
A
E
I
Y
H
M
L
K
K
V
I
H
D
R
--
G
--
F
S
-
T
T
--
V
--
G
-------
D
E
G
G
F
A
P
S
L
P
T
N
D
A
P
L
Q
L
I
M
E
A
I
E
K
A
G
Y
R
P
G
E
Q
I
V
I
A
L
D
P
A
T
T
E
I
F
--
E
-----
D
G
K
Y
---
H
L
------
K
----
R
--------
E
--------
G
-
R
S
L
S
S
A
-----
E
M
V
-
D
Y
W
V
D
L
V
N
R
Y
P
I
I
S
L
E
D
G
L
A
E
D
D
W
E
G
W
A
L
L
R
A
K
L
G
D
R
V
Q
L
V
G
D
D
F
L
V
-
T
N
V
Q
R
L
Q
R
A
I
E
A
K
A
A
N
S
I
L
I
K
L
N
Q
I
G
S
L
T
E
T
L
S
A
I
Q
L
A
Q
R
S
G
W
T
A
V
V
S
H
R
S
G
E
S
E
D
V
T
I
A
D
L
V
V
A
T
N
A
G
Q
I
K
T
G
A
P
A
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
S
A
A
R
Y
A
G
R
S
A
F
------
24
PsiBlast_CBE
71.61
73%
29
- C1 -
5BOE
5
ENO_STAAU
B:
[1-433]
M
P
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
L
T
E
S
G
A
----------
F
G
R
A
L
V
P
S
G
A
-
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
K
G
V
T
K
A
V
E
N
V
N
E
I
I
A
P
E
I
I
--
E
GE
F
S
--
V
L
D
Q
V
S
I
D
K
M
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
L
L
G
Q
P
L
Y
K
Y
---
L
G
---
G
F
-----
N
-----
G
---
K
Q
----
L
P
V
P
M
M
N
I
V
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
L
P
V
G
A
T
T
F
K
E
S
L
R
W
G
T
E
I
F
H
N
L
K
S
I
L
S
K
R
--
G
--
L
E
-
T
A
--
V
--
G
-------
D
E
G
G
F
A
P
K
F
E
G
T
E
D
A
V
E
T
I
I
Q
A
I
E
A
A
G
Y
K
P
G
E
E
V
F
L
G
F
D
C
A
S
S
E
F
Y
--
E
-----
N
G
V
Y
---
D
Y
------
S
KFE-
G
--------
E
H-------
G
-
A
K
R
T
A
A
-----
E
Q
V
-
D
Y
L
E
Q
L
V
D
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
Q
L
T
E
R
I
G
D
R
V
Q
L
V
G
D
D
L
F
V
-
T
N
T
E
I
L
A
K
G
I
E
N
G
I
G
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
D
A
I
E
M
A
Q
K
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
E
L
F
E
T
A
K
Y
D
G
I
K
S
F
Y
N
L
D
--
111
HHSearch
70.37
74%
28
- C1 -
5BOE
4
ENO_STAAU
A:
[1-433]
M
P
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
L
T
E
S
G
A
----------
F
G
R
A
L
V
P
S
G
A
-
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
K
G
V
T
K
A
V
E
N
V
N
E
I
I
A
P
E
I
I
--
E
--
G
E
FS
V
L
D
Q
V
S
I
D
K
M
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
L
L
G
Q
P
L
Y
K
Y
---
L
G
---
G
F
-----
N
-----
G
---
K
Q
----
L
P
V
P
M
M
N
I
V
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
L
P
V
G
A
T
T
F
K
E
S
L
R
W
G
T
E
I
F
H
N
L
K
S
I
L
S
K
R
--
G
--
L
E
-
T
A
--
V
--
G
-------
D
E
G
G
F
A
P
K
F
E
G
T
E
D
A
V
E
T
I
I
Q
A
I
E
A
A
G
Y
K
P
G
E
E
V
F
L
G
F
D
C
A
S
S
E
F
Y
E
-------
N
G
V
Y
---
D
Y
------
S
KFEG
E
--------
H
--------
G
-
A
K
R
T
A
A
-----
E
Q
V
-
D
Y
L
E
Q
L
V
D
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
Q
L
T
E
R
I
G
D
R
V
Q
L
V
G
D
D
L
F
V
-
T
N
T
E
I
L
A
K
G
I
E
N
G
I
G
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
D
A
I
E
M
A
Q
K
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
E
L
F
E
T
A
K
Y
D
G
I
K
S
F
Y
N
L
D
--
3
PsiBlast_PDB
70.01
73%
28
- C1 -
5BOE
4
ENO_STAAU
A:
[1-433]
M
P
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
L
T
E
S
G
A
----------
F
G
R
A
L
V
P
S
G
A
-
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
K
G
V
T
K
A
V
E
N
V
N
E
I
I
A
P
E
I
I
--
E
G
E
F
S
--
V
L
D
Q
V
S
I
D
K
M
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
L
L
G
Q
P
L
Y
K
Y
---
L
G
---
G
F
-----
N
-----
G
---
K
Q
----
L
P
V
P
M
M
N
I
V
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
L
P
V
G
A
T
T
F
K
E
S
L
R
W
G
T
E
I
F
H
N
L
K
S
I
L
S
K
R
--
G
--
L
E
-
T
A
--
V
--
G
-------
D
E
G
G
F
A
P
K
F
E
G
T
E
D
A
V
E
T
I
I
Q
A
I
E
A
A
G
Y
K
P
G
E
E
V
F
L
G
F
D
C
A
S
S
E
F
Y
--
E
-----
N
G
V
Y
---
D
Y
------
S
KFE-
G
--------
E
H-------
G
-
A
K
R
T
A
A
-----
E
Q
V
-
D
Y
L
E
Q
L
V
D
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
Q
L
T
E
R
I
G
D
R
V
Q
L
V
G
D
D
L
F
V
-
T
N
T
E
I
L
A
K
G
I
E
N
G
I
G
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
D
A
I
E
M
A
Q
K
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
E
L
F
E
T
A
K
Y
D
G
I
K
S
F
Y
N
L
D
--
74
PsiBlast_CBE
68.45
54%
2
- C1 -
3QTP
6
ENO1_ENTHI
A:
[8-426]
---
I
Q
K
V
H
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
I
T
T
G
K
G
M
----------
F
-
R
S
C
V
P
S
G
A
-
S
T
G
V
H
E
A
V
E
L
R
D
G
D
K
K
R
Y
G
G
K
G
V
L
K
A
V
E
N
V
N
T
I
I
G
P
A
L
L
--
G
--
K
N
--
V
L
N
Q
A
E
L
D
E
M
M
I
K
L
D
G
T
N
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
S
I
C
R
A
A
A
A
E
K
G
L
P
L
Y
K
Y
---
L
A
E
L
T
G
H
-----
K
-----
E
---
M
T
----
M
P
V
P
C
F
N
V
I
N
G
G
A
H
A
G
N
A
L
A
M
Q
E
F
M
I
C
P
T
G
A
T
N
F
H
E
A
L
R
M
A
A
E
T
Y
Q
C
L
K
V
V
I
K
A
K
Y-
G
--
Q
D
A
T
N
--
V
--
G
-------
D
E
G
G
F
A
P
N
V
S
G
A
R
E
A
L
D
L
L
V
E
A
I
A
K
A
G
Y
T
--
G
K
I
E
I
A
M
D
C
A
A
S
E
F
Y
N
E
E
-----
T
K
K
Y
---
D
L
------
G
----
K
--------
K
IPADKKDP
S
-
L
V
K
D
V
D
-----
G
L
I
-
A
E
Y
V
D
Y
G
K
H
Y
P
I
A
S
I
E
D
P
F
A
E
D
D
W
A
A
W
N
K
F
T
V
E
H
G
-
N
F
Q
I
V
G
D
D
L
L
V
-
T
N
P
A
R
V
Q
M
A
M
D
K
N
A
C
N
S
V
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
K
T
I
K
M
A
Q
E
K
G
W
G
V
M
A
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
N
C
K
Q
I
K
T
G
A
P
C
R
S
E
R
L
C
K
Y
N
Q
L
M
R
I
E
E
E
L
------------------
73
PsiBlast_CBE
67.34
54%
1
- C1 -
3QTP
6
ENO1_ENTHI
B:
[8-426]
---
I
Q
K
V
H
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
I
T
T
G
K
G
M
----------
F
-
R
S
C
V
P
S
G
A
-
S
T
G
V
H
E
A
V
E
L
R
D
G
D
K
K
R
Y
G
G
K
G
V
L
K
A
V
E
N
V
N
T
I
I
G
P
A
L
L
--
G
--
K
N
--
V
L
N
Q
A
E
L
D
E
M
M
I
K
L
D
G
T
N
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
S
I
C
R
A
A
A
A
E
K
G
L
P
L
Y
K
Y
---
L
A
E
L
T
G
H
-----
K
-----
E
---
M
T
----
M
P
V
P
C
F
N
V
I
N
G
G
A
H
A
G
N
A
L
A
M
Q
E
F
M
I
C
P
T
G
A
T
N
F
H
E
A
L
R
M
A
A
E
T
Y
Q
C
L
K
V
V
I
K
A
K
Y-
G
--
Q
D
A
T
N
--
V
--
G
-------
D
E
G
G
F
A
P
N
V
S
G
A
R
E
A
L
D
L
L
V
E
A
I
A
K
A
G
Y
T
--
G
K
I
E
I
A
M
D
C
A
A
S
E
F
Y
N
E
E
-----
T
K
K
Y
---
D
L
------
G
----
K
--------
K
IPADKKDP
S
-
L
V
K
D
V
D
-----
G
L
I
-
A
E
Y
V
D
Y
G
K
H
Y
P
I
A
S
I
E
D
P
F
A
E
D
D
W
A
A
W
N
K
F
T
V
E
H
G
-
N
F
Q
I
V
G
D
D
L
L
V
-
T
N
P
A
R
V
Q
M
A
M
D
K
N
A
C
N
S
V
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
K
T
I
K
M
A
Q
E
K
G
W
G
V
M
A
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
N
C
K
Q
I
K
T
G
A
P
C
R
S
E
R
L
C
K
Y
N
Q
L
M
R
I
E
E
E
L
------------------
56
PsiBlast_CBE
63.56
52%
24
- C1 -
3UCC
4
ENOG_HUMAN
A:
[2-426]
---
I
Q
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
---
G
N
-----
S
-----
D
---
L
I
----
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A
T
N
--
V
--
G
-------
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
-----
D
G
K
Y
---
D
L
------
D
----
F
--------
K
--------
S
-
P
T
D
P
S
R
YIT
G
D
Q
L
G
-
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
T
V
-
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
--------
53
PsiBlast_CBE
63.50
52%
23
- C1 -
3UCD
3
ENOG_HUMAN
B:
[2-426]
---
I
Q
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
IAQ
L
A
---
G
N
-----
S
-----
D
---
L
I
----
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A
T
N
--
V
--
G
-------
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
-----
D
G
K
Y
---
D
L
------
D
----
F
--------
K
--------
S
-
P
T
D
P
S
R
YITGD
Q
L
G
-
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
T
V
-
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
--------
58
PsiBlast_CBE
63.46
52%
23
- C1 -
3UJS
4
ENOG_HUMAN
A:
[2-426]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
---
G
N
-----
S
-----
D
---
L
I
----
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A
T
N
--
V
--
G
-------
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
-----
D
G
K
Y
---
D
L
------
D
----
F
--------
K
--------
S
-
P
T
D
P
S
R
YIT
G
D
Q
L
G
-
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
T
V
-
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
--------
97
PsiBlast_CBE
63.36
50%
18
- C1 -
5ENL
2
ENO1_YEAST
A:
[2-435]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
--
V
S
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
K----
S
---
K
T
SP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
L
K
S
L
T
K
K
R
--
Y
--
G
A
-
S
A
GN
V
--
G
-------
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
-----
D
G
K
Y
---
D
L
DFKNPN
S
----
D
--------
K
--------
S
-
K
W
L
T
G
P
-----
Q
L
A
-
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
T
V
-
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
-
F
H
H
G
D
K
-
54
PsiBlast_CBE
62.95
52%
25
- C1 -
3UCD
3
ENOG_HUMAN
A:
[2-426]
---
I
Q
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
---
G
N
-----
S
-----
D
---
L
I
----
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A
T
N
--
V
--
G
-------
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
-----
D
G
K
Y
---
D
L
------
D
----
F
--------
K
--------
S
-
P
T
D
P
S
R
YIT
G
D
Q
L
G
-
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
T
V
-
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
--------
60
PsiBlast_CBE
62.92
52%
25
- C1 -
3UJR
4
ENOG_HUMAN
A:
[2-426]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
---
G
N
-----
S
-----
D
---
L
I
----
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A
T
N
--
V
--
G
-------
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
-----
D
G
K
Y
---
D
L
------
D
----
F
--------
K
--------
S
-
P
T
D
P
S
R
YIT
G
D
Q
L
G
-
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
T
V
-
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
--------
57
PsiBlast_CBE
62.91
52%
23
- C1 -
3UJS
3
ENOG_HUMAN
B:
[2-426]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
IAQ
L
A
---
G
N
-----
S
-----
D
---
L
I
----
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A
T
N
--
V
--
G
-------
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
-----
D
G
K
Y
---
D
L
------
D
----
F
--------
K
--------
S
-
P
T
D
P
S
R
YITGD
Q
L
G
-
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
T
V
-
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
--------
62
PsiBlast_CBE
62.89
52%
27
- C1 -
3UJF
3
ENOG_HUMAN
A:
[2-426]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
---
G
N
-----
S
-----
D
---
L
I
----
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A
T
N
--
V
--
G
-------
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
-----
D
G
K
Y
---
D
L
------
D
----
F
--------
K
--------
S
-
P
T
D
P
S
R
YIT
G
D
Q
L
G
-
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
T
V
-
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
--------
59
PsiBlast_CBE
62.76
52%
26
- C1 -
3UJR
3
ENOG_HUMAN
B:
[2-426]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
IAQ
L
A
---
G
N
-----
S
-----
D
---
L
I
----
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A
T
N
--
V
--
G
-------
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
-----
D
G
K
Y
---
D
L
------
D
----
F
--------
K
--------
S
-
P
T
D
P
S
R
YITGD
Q
L
G
-
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
T
V
-
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
--------
64
PsiBlast_CBE
62.72
52%
24
- C1 -
3UJE
4
ENOG_HUMAN
A:
[2-426]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
---
G
N
-----
S
-----
D
---
L
I
----
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A
T
N
--
V
--
G
-------
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
-----
D
G
K
Y
---
D
L
------
D
----
F
--------
K
--------
S
-
P
T
D
P
S
R
YIT
G
D
Q
L
G
-
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
T
V
-
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
--------
117
HHSearch
62.71
52%
25
- C1 -
3QTP
6
ENO1_ENTHI
A:
[5-440]
S
M
S
I
Q
K
V
H
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
I
T
T
G
K
G
M
F
R
S
C
V
P
S
GAS
T
G
V
H
E
A
V
E
L
R
-
D
G
D
-----------
K
K
R
Y
G
G
K
G
V
L
K
A
V
E
N
V
N
T
I
I
G
P
A
L
L
--
G
--
K
N
--
V
L
N
Q
A
E
L
D
E
M
M
I
K
L
D
G
T
N
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
S
I
C
R
A
A
A
A
E
K
G
L
P
L
Y
K
Y
---
L
A
---
E
L
-----
T
-----
G
HK
E
M
T
----
M
P
V
P
C
F
N
V
I
N
G
G
A
H
A
G
N
A
L
A
M
Q
E
F
M
I
C
P
T
G
A
T
N
F
H
E
A
L
R
M
A
A
E
T
Y
Q
C
L
K
V
V
I
K
A
K
--
Y
GQ
D
A
-
T
N
--
V
--
G
-------
D
E
G
G
F
A
P
N
V
S
G
A
R
E
A
L
D
L
L
V
E
A
I
A
K
A
G
Y
--
T
G
K
I
E
I
A
M
D
C
A
A
S
E
F
Y
N
E
E
-----
T
K
K
Y
---
D
L
------
G
----
K
KIPADKKD
P
--------
S
-
L
V
K
D
V
D
-----
G
L
I
-
A
E
Y
V
D
Y
G
K
H
Y
P
I
A
S
I
E
D
P
F
A
E
D
D
W
A
A
W
N
K
F
T
V
E
H
G
-
N
F
Q
I
V
G
D
D
L
L
V
-
T
N
P
A
R
V
Q
M
A
M
D
K
N
A
C
N
S
V
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
K
T
I
K
M
A
Q
E
K
G
W
G
V
M
A
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
N
C
K
Q
I
K
T
G
A
P
C
R
S
E
R
L
C
K
Y
N
Q
L
M
R
I
E
E
E
L
G
N
-
I
P
Y
A
G
K
N
-
W
R
N
S
T
--
96
PsiBlast_CBE
62.47
50%
18
- C1 -
6ENL
2
ENO1_YEAST
A:
[2-435]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
--
V
S
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
K----
S
---
K
T
SP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
L
K
S
L
T
K
K
R
--
Y
--
G
A
-
S
A
GN
V
--
G
-------
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
-----
D
G
K
Y
---
D
L
DFKNPN
S
----
D
--------
K
--------
S
-
K
W
L
T
G
P
-----
Q
L
A
-
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
T
V
-
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
-
F
H
H
G
D
K
-
63
PsiBlast_CBE
62.42
52%
25
- C1 -
3UJE
3
ENOG_HUMAN
B:
[2-426]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
IAQ
L
A
---
G
N
-----
S
-----
D
---
L
I
----
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A
T
N
--
V
--
G
-------
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
-----
D
G
K
Y
---
D
L
------
D
----
F
--------
K
--------
S
-
P
T
D
P
S
R
YITGD
Q
L
G
-
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
T
V
-
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
--------
55
PsiBlast_CBE
62.34
52%
24
- C1 -
3UCC
3
ENOG_HUMAN
B:
[2-426]
---
I
Q
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
IAQ
L
A
---
G
N
-----
S
-----
D
---
L
I
----
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A
T
N
--
V
--
G
-------
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
-----
D
G
K
Y
---
D
L
------
D
----
F
--------
K
--------
S
-
P
T
D
P
S
R
YITGD
Q
L
G
-
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
T
V
-
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
--------
61
PsiBlast_CBE
62.15
52%
25
- C1 -
3UJF
3
ENOG_HUMAN
B:
[2-426]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
--
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
IAQ
L
A
---
G
N
-----
S
-----
D
---
L
I
----
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A
T
N
--
V
--
G
-------
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
--
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
--
R
-----
D
G
K
Y
---
D
L
------
D
----
F
--------
K
--------
S
-
P
T
D
P
S
R
YITGD
Q
L
G
-
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
T
V
-
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
H
N
--------
121
HHSearch
62.04
51%
29
- C1 -
2AL1
3
ENO1_YEAST
A:
[1-429]
--
A
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
-----------
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
--
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
KSKTS
P
---
Y
V
----
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
L
K
S
L
T
K
K
R
YG
A
--
S
A
-
G
N
--
V
--
G
-------
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
--
D
G
K
V
K
I
G
L
D
C
A
S
S
E
F
F
K
-------
D
G
K
Y
---
D
L
------
D
----
F
KNPNSD--
K
--------
S
-
K
W
L
T
G
P
-----
Q
L
A
-
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
--
G
I
Q
I
V
A
D
D
L
-
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
--------
95
PsiBlast_CBE
62.04
50%
21
- C1 -
7ENL
2
ENO1_YEAST
A:
[2-435]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
--
V
S
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
K----
S
---
K
T
SP
Y
V
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
L
K
S
L
T
K
K
R
--
Y
--
G
A
-
S
A
GN
V
--
G
-------
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
--
G
K
V
K
I
G
L
D
C
A
S
S
E
F
F
--
K
-----
D
G
K
Y
---
D
L
DFKNPN
S
----
D
--------
K
--------
S
-
K
W
L
T
G
P
-----
Q
L
A
-
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
T
V
-
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
-
F
H
H
G
D
K
-
91
PsiBlast_CBE
61.14
51%
17
- C1 -
2PTZ
5
?
A:
[6-426]
---
I
Q
K
V
H
G
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
T
T
E
K
G
V
----------
F
-
R
S
A
V
P
S
G
A
-
S
T
G
V
Y
E
A
C
E
L
R
D
G
D
K
K
R
Y
V
G
K
G
C
L
Q
A
V
K
N
V
N
E
V
I
G
P
A
L
I
--
G
--
R
D
--
E
L
K
Q
E
E
L
D
T
L
M
L
R
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
A
I
S
K
A
A
A
A
A
K
G
V
P
L
Y
R
Y
---
L
A
S
L
A
G
T
-----
K
-----
E
---
L
R
----
L
P
V
P
C
F
N
V
I
N
G
G
K
H
A
G
N
A
L
P
F
Q
E
F
M
I
A
P
V
K
A
T
S
F
S
E
A
L
R
M
G
S
E
V
Y
H
S
L
R
G
I
I
K
K
K
--
Y
--
G
Q
-
D
A
--
V
NV
G
-------
D
E
G
G
F
A
P
P
I
K
D
I
N
E
P
L
P
I
L
M
E
A
I
E
E
A
G
H
R
--
G
K
F
A
I
C
M
D
C
A
A
S
E
T
Y
D
E
K
-----
K
Q
Q
Y
---
N
L
TFK---
S
----
P
--------
E
--------
P
-
T
W
V
T
A
E
-----
Q
L
R
-
E
T
Y
C
K
W
A
H
D
Y
P
I
V
S
I
E
D
P
Y
D
Q
D
D
F
A
G
F
A
G
I
T
E
A
L
K
G
K
T
Q
I
V
G
D
D
L
T
V
-
T
N
T
E
R
I
K
M
A
I
E
K
K
A
C
N
S
L
L
L
K
I
N
Q
I
G
T
I
S
E
A
I
A
S
S
K
L
C
M
E
N
G
W
S
V
M
V
S
H
R
S
G
E
T
E
D
T
Y
I
A
D
L
V
V
A
L
G
S
G
Q
I
K
T
G
A
P
C
R
G
E
R
T
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
A
H
A
K
F
------------
89
PsiBlast_CBE
60.64
51%
16
- C1 -
2PU1
5
?
A:
[6-426]
---
I
Q
K
V
H
G
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
T
T
E
K
G
V
----------
F
-
R
S
A
V
P
S
G
A
-
S
T
G
V
Y
E
A
C
E
L
R
D
G
D
K
K
R
Y
V
G
K
G
C
L
Q
A
V
K
N
V
N
E
V
I
G
P
A
L
I
--
G
--
R
D
--
E
L
K
Q
E
E
L
D
T
L
M
L
R
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
A
I
S
K
A
A
A
A
A
K
G
V
P
L
Y
R
Y
---
L
A
S
L
A
G
T
-----
K
-----
E
---
L
R
----
L
P
V
P
C
F
N
V
I
N
G
G
K
H
A
G
N
A
L
P
F
Q
E
F
M
I
A
P
V
K
A
T
S
F
S
E
A
L
R
M
G
S
E
V
Y
H
S
L
R
G
I
I
K
K
K
--
Y
--
G
Q
-
D
A
--
V
NV
G
-------
D
E
G
G
F
A
P
P
I
K
D
I
N
E
P
L
P
I
L
M
E
A
I
E
E
A
G
H
R
--
G
K
F
A
I
C
M
D
C
A
A
S
E
T
Y
D
E
K
-----
K
Q
Q
Y
---
N
L
TFK---
S
----
P
--------
E
--------
P
-
T
W
V
T
A
E
-----
Q
L
R
-
E
T
Y
C
K
W
A
H
D
Y
P
I
V
S
I
E
D
P
Y
D
Q
D
D
F
A
G
F
A
G
I
T
E
A
L
K
G
K
T
Q
I
V
G
D
D
L
T
V
-
T
N
T
E
R
I
K
M
A
I
E
K
K
A
C
N
S
L
L
L
K
I
N
Q
I
G
T
I
S
E
A
I
A
S
S
K
L
C
M
E
N
G
W
S
V
M
V
S
H
R
S
G
E
T
E
D
T
Y
I
A
D
L
V
V
A
L
G
S
G
Q
I
K
T
G
A
P
C
R
G
E
R
T
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
A
H
A
K
F
------------
90
PsiBlast_CBE
60.35
51%
19
- C1 -
2PU0
7
?
A:
[6-426]
---
I
Q
K
V
H
G
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
T
T
E
K
G
V
----------
F
-
R
S
A
V
P
S
G
A
-
S
T
G
V
Y
E
A
C
E
L
R
D
G
D
K
K
R
Y
V
G
K
G
C
L
Q
A
V
K
N
V
N
E
V
I
G
P
A
L
I
--
G
--
R
D
--
E
L
K
Q
E
E
L
D
T
L
M
L
R
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
A
I
S
K
A
A
A
A
A
K
G
V
P
L
Y
R
Y
---
L
A
S
L
A
G
T
-----
K
-----
E
---
L
R
----
L
P
V
P
C
F
N
V
I
N
G
G
K
H
A
G
N
A
L
P
F
Q
E
F
M
I
A
P
V
K
A
T
S
F
S
E
A
L
R
M
G
S
E
V
Y
H
S
L
R
G
I
I
K
K
K
--
Y
--
G
Q
-
D
A
--
V
NV
G
-------
D
E
G
G
F
A
P
P
I
K
D
I
N
E
P
L
P
I
L
M
E
A
I
E
E
A
G
H
R
--
G
K
F
A
I
C
M
D
C
A
A
S
E
T
Y
D
E
K
-----
K
Q
Q
Y
---
N
L
TFK---
S
----
P
--------
E
--------
P
-
T
W
V
T
A
E
-----
Q
L
R
-
E
T
Y
C
K
W
A
H
D
Y
P
I
V
S
I
E
D
P
Y
D
Q
D
D
F
A
G
F
A
G
I
T
E
A
L
K
G
K
T
Q
I
V
G
D
D
L
T
V
-
T
N
T
E
R
I
K
M
A
I
E
K
K
A
C
N
S
L
L
L
K
I
N
Q
I
G
T
I
S
E
A
I
A
S
S
K
L
C
M
E
N
G
W
S
V
M
V
S
H
R
S
G
E
T
E
D
T
Y
I
A
D
L
V
V
A
L
G
S
G
Q
I
K
T
G
A
P
C
R
G
E
R
T
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
A
H
A
K
F
------------
92
PsiBlast_CBE
60.18
51%
19
- C1 -
2PTY
4
?
A:
[6-426]
---
I
Q
K
V
H
G
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
T
T
E
K
G
V
----------
F
-
R
S
A
V
P
S
G
A
-
S
T
G
V
Y
E
A
C
E
L
R
D
G
D
K
K
R
Y
V
G
K
G
C
L
Q
A
V
K
N
V
N
E
V
I
G
P
A
L
I
--
G
--
R
D
--
E
L
K
Q
E
E
L
D
T
L
M
L
R
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
A
I
S
K
A
A
A
A
A
K
G
V
P
L
Y
R
Y
---
L
A
S
L
A
G
T
-----
K
-----
E
---
L
R
----
L
P
V
P
C
F
N
V
I
N
G
G
K
H
A
G
N
A
L
P
F
Q
E
F
M
I
A
P
V
K
A
T
S
F
S
E
A
L
R
M
G
S
E
V
Y
H
S
L
R
G
I
I
K
K
K
--
Y
--
G
Q
-
D
A
--
V
NV
G
-------
D
E
G
G
F
A
P
P
I
K
D
I
N
E
P
L
P
I
L
M
E
A
I
E
E
A
G
H
R
--
G
K
F
A
I
C
M
D
C
A
A
S
E
T
Y
D
E
K
-----
K
Q
Q
Y
---
N
L
TFK---
S
----
P
--------
E
--------
P
-
T
W
V
T
A
E
-----
Q
L
R
-
E
T
Y
C
K
W
A
H
D
Y
P
I
V
S
I
E
D
P
Y
D
Q
D
D
F
A
G
F
A
G
I
T
E
A
L
K
G
K
T
Q
I
V
G
D
D
L
T
V
-
T
N
T
E
R
I
K
M
A
I
E
K
K
A
C
N
S
L
L
L
K
I
N
Q
I
G
T
I
S
E
A
I
A
S
S
K
L
C
M
E
N
G
W
S
V
M
V
S
H
R
S
G
E
T
E
D
T
Y
I
A
D
L
V
V
A
L
G
S
G
Q
I
K
T
G
A
P
C
R
G
E
R
T
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
A
H
A
K
F
------------
101
Fugue
59.39
51%
28
- C1 -
1ONE
3
ENO1_YEAST
A:
[1-436]
--
A
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
-----------
V
F
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
A
N
I
D
--
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
S
KSKT
S
-----
P
---
Y
V
----
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
L
K
S
L
T
K
K
R
YG
A
--
S
A
-
G
N
--
V
--
G
-------
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
G
--
K
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
-G
K
Y
D
L
D
F
K
N
---
P
N
------
S
----
D
--------
K
--------
S
-
K
W
L
T
G
P
-----
Q
L
A
-
D
L
Y
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
--
A
G
I
Q
I
V
A
D
D
L
T
V
-
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
-
E
N
F
H
H
G
D
K
L
120
HHSearch
54.30
49%
36
- C1 -
2PTZ
5
?
A:
[3-427]
H
M
T
I
Q
K
V
H
G
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
T
T
E
K
G
V
F
R
S
A
V
P
S
G
AS
T
G
V
Y
E
A
C
E
L
R
-
D
G
D
-----------
K
K
R
Y
V
G
K
G
C
L
Q
A
V
K
N
V
N
E
V
I
G
P
A
L
I
--
G
--
R
D
--
E
L
K
Q
E
E
L
D
T
L
M
L
R
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
A
I
S
K
A
A
A
A
A
K
G
V
P
L
Y
R
Y
---
L
A
---
S
L
-----
A
GTK--
E
---
L
R
----
L
P
V
P
C
F
N
V
I
N
G
G
K
H
A
G
N
A
L
P
F
Q
E
F
M
I
A
P
V
K
A
T
S
F
S
E
A
L
R
M
G
S
E
V
Y
H
S
L
R
G
I
I
K
----------
K
K
--
Y
--
G
QDAVNVG
D
E
G
G
F
A
P
P
I
K
D
I
N
E
P
L
P
I
L
M
E
A
I
E
E
A
G
H
--
R
G
K
F
A
I
C
M
D
C
A
A
S
E
T
Y
D
E
K
-----
K
Q
Q
Y
---
N
L
------
T
----
F
--------
K
SP
E
-----
P
-
T
W
V
T
A
E
-----
Q
L
R
E
T
Y
C
K
W
A
-
H
D
Y
P
I
V
S
I
E
D
P
Y
D
Q
D
D
F
A
G
F
A
G
I
T
E
A
L
K
G
K
T
Q
I
V
G
D
D
L
T
V
-
T
N
T
E
R
I
K
M
A
I
E
K
K
A
C
N
S
L
L
L
K
I
N
Q
I
G
T
I
S
E
A
I
A
S
S
K
L
C
M
E
N
G
W
S
V
M
V
S
H
R
S
G
E
T
E
D
T
Y
I
A
D
L
V
V
A
L
G
S
G
Q
I
K
T
G
A
P
C
R
G
E
R
T
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
A
H
A
K
F
G
-----------