@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu33910: (2016-07-27 )
MSKKPAALIILDGFGLRNETVGNAVALAKKPNFDRYWNQYPHQTLTASGEAVGLPEGQMGNSEVGHLNIGAGRIVYQSLTRVNVAIREGEFERNQTFLDAISNAKENNKALHLFGLLSDGGVHSHINHLFALLKLAKKEGLTKVYIHGFLDGRDVGPQTAKTYINQLNDQIKEIGVGEIASISGRYYSMDRDKRWDRVEKAYRAMAYGEGPSYRSALDVVDDSYANGIYDEFVIPSVITKENGEPVAKIQDGDSVIFYNFRPDRAIQISNTFTNKDFRDFDRGENYPKNLYFVCLTHFSETVDGYVAFKPINLDNTVGEVLSQHGLKQLRIAETEKYPHVTFFMSGGREAEFPGEERILINSPKVATYDLKPEMSAYEVKDALVKEIEADKHDAIILNFANPDMVGHSGMVEPTIKAIEAVDECLGEVVDAILAKGGHAIITADHGNADILITESGEPHTAHTTNPVPVIVTKEGITLREGGILGDLAPTLLDLLGVEKPKEMTGTSLIQK
Atome Classification :
(20 SA)
.........10........20........30........40.-.-......50....-...-.60........70........80........90........100.......110.......120.......130.......140.......150.......160......---.---170...-.---...180..-...-..190.-.......200.......210.......220--.....--.--..230.......240.......250.......260.......270.......280...-....290.......300.--.......310.......320.......330.......340.......350.--......360..-.....370.......380......--.390.......400.-......----------------------------------------------------------410.......420.......430..----.....440.......450...----------.--.------------..460.......470.....-------..-------480-------.......490.......500.......510
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSKK
P
A
A
L
I
I
L
DGFGLRNETVGN
A
V
A
LAKKP
N
F
D
R
Y
W
N
QYPH-Q-TLTASGEAVGLP-EGQ-MGNSEVG
H
L
NIG
A
G
R
I
V
Y
Q
S
L
T
R
V
N
V
A
I
REGEFER
N
Q
T
F
L
D
A
I
SNAKENN
K
A
L
H
L
F
G
L
LSDGG
V
H
S
H
I
N
H
L
F
A
L
L
K
L
A
K
KEG
L
T
K
V
Y
I
H
G
FLDGRDV
G
P
Q
T
A
K
T
Y
I
N
Q
L
N
---
D
---
Q
I
K
EIG-V---G
E
I
A
SIS
G
-
R
Y
Y-SMD
R
-
D
-
K
R
W
D
R
V
E
K
A
Y
R
A
MAYGEGPSY
R
S
A
L
D
VVD---DSYAN--G--
I
Y
D
EFVI
P
S
V
ITKENGE
P
V
A
K
IQDG
D
S
V
I
F
Y
NFRPD
R
A
I
Q
I
SNTFTNKDFRDFDRGEN-YPK
N
L
Y
F
V
C
L
T
H
F
S
ET-V--D
G
Y
V
A
F
K
PINLD
N
T
V
G
E
V
L
S
QHG
L
K
Q
L
R
IAETEKYP
H
V
T
F
F
MSGGREAEFP--GE
E
R
I
L
INSP
K
-
V
A
T
Y
DLKPEM
S
A
Y
E
V
K
D
A
L
V
K
E
I
E--ADKH
D
A
I
I
L
NFANPD-MVGHSG----------------------------------------------------------MV
E
P
T
I
K
A
I
E
A
V
D
E
C
L
G
E
V
V
D
A
I
L
A----KG
G
H
A
I
I
T
ADHGN
A
D
I
L
I
TES----------G--E------------PHTAHTTN
P
V
P
V
I
V
TKE
G
I
T
-------LR-------EGG-------IL
G
D
L
A
P
T
L
L
D
L
LGVEK
P
K
EMTGTSLIQK
45
Fugue
97.25
80%
-83
- C4 -
1EJJ
3
GPMI_GEOSE
A:
[3-510]
--
K
K
P
V
A
L
I
I
L
D
G
F
A
L
R
D
E
T
Y
G
N
A
V
A
Q
A
N
K
P
N
F
D
R
Y
W
N
E
Y
P
H
-
T
-
T
L
K
A
C
G
E
A
V
G
L
P
-
E
G
Q
-
M
G
N
S
E
V
G
H
L
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
I
A
I
R
E
G
E
F
D
R
N
E
T
F
L
A
A
M
N
H
V
K
Q
H
G
T
S
L
H
L
F
G
L
L
S
D
G
G
V
H
S
H
I
H
H
L
Y
A
L
L
R
L
A
A
K
E
G
V
K
R
V
Y
I
H
G
F
L
D
G
R
D
V
G
P
Q
T
A
P
Q
Y
I
K
E
L
Q
---
E
---
K
I
K
E
Y
G
-
V
---
G
E
I
A
T
L
S
G
-
R
Y
Y
-
S
M
D
R
-
D
-
K
R
W
D
R
V
E
K
A
Y
R
A
M
V
Y
G
E
G
P
T
Y
R
D
P
L
E
C
I
E
---
D
S
Y
K
H
--
G
--
I
Y
D
E
F
V
L
P
S
V
I
V
R
E
D
G
R
P
V
A
T
I
Q
D
N
D
A
I
I
F
Y
N
F
R
P
D
R
A
I
Q
I
S
N
T
F
T
N
E
D
F
R
E
F
D
R
G
P
K
-
H
P
K
H
L
F
F
V
C
L
T
H
F
S
E
T
-
V
--
A
G
Y
V
A
F
K
P
T
N
L
D
N
T
I
G
E
V
L
S
Q
H
G
L
R
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
F
F
M
S
G
G
R
E
E
E
F
P
--
G
E
D
R
I
L
I
N
S
P
K
-
V
P
T
Y
D
L
K
P
E
M
S
A
Y
E
V
T
D
A
L
L
K
E
I
E
--
A
D
K
Y
D
A
I
I
L
N
Y
A
N
P
D
-
M
V
G
H
S
G
----------------------------------------------------------
K
L
E
P
T
I
K
A
V
E
A
V
D
E
C
L
G
K
V
V
D
A
I
L
A
----
K
G
G
I
A
I
I
T
A
D
H
G
N
A
D
E
V
L
T
P
D
----------
G
--
K
------------
P
Q
T
A
H
T
T
N
P
V
P
V
I
V
T
K
K
G
I
K
-------
L
R
-------
D
G
G
-------
I
L
G
D
L
A
P
T
M
L
D
L
L
G
L
P
Q
P
K
E
M
T
G
K
S
L
I
V
-
3
PsiBlast_PDB
96.10
80%
-81
- C4 -
1O98
9
GPMI_GEOSE
A:
[2-510]
-
S
K
K
P
V
A
L
I
I
L
D
G
F
A
L
R
D
E
T
Y
G
N
A
V
A
Q
A
N
K
P
N
F
D
R
Y
W
N
E
Y
P
H
-
T
-
T
L
K
A
C
G
E
A
V
G
L
P
-
E
G
Q
-
M
G
N
S
E
V
G
H
L
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
I
A
I
R
E
G
E
F
D
R
N
E
T
F
L
A
A
M
N
H
V
K
Q
H
G
T
S
L
H
L
F
G
L
L
S
D
G
G
V
H
S
H
I
H
H
L
Y
A
L
L
R
L
A
A
K
E
G
V
K
R
V
Y
I
H
G
F
L
D
G
R
D
V
G
P
Q
T
A
P
Q
Y
I
K
E
L
Q
---
E
---
K
I
K
E
Y
G
-
V
---
G
E
I
A
T
L
S
G
-
R
Y
Y
-
S
M
D
R
-
D
-
K
R
W
D
R
V
E
K
A
Y
R
A
M
V
Y
G
E
G
P
T
Y
R
D
P
L
E
C
I
E
---
D
S
Y
K
H
--
G
--
I
Y
D
E
F
V
L
P
S
V
I
V
R
E
D
G
R
P
V
A
T
I
Q
D
N
D
A
I
I
F
Y
N
F
R
P
D
R
A
I
Q
I
S
N
T
F
T
N
E
D
F
R
E
F
D
R
G
P
K
-
H
P
K
H
L
F
F
V
C
L
T
H
F
S
E
T
-
V
--
A
G
Y
V
A
F
K
P
T
N
L
D
N
T
I
G
E
V
L
S
Q
H
G
L
R
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
F
F
M
S
G
G
R
E
E
E
F
P
--
G
E
D
R
I
L
I
N
S
P
K
-
V
P
T
Y
D
L
K
P
E
M
S
A
Y
E
V
T
D
A
L
L
K
E
I
E
--
A
D
K
Y
D
A
I
I
L
N
Y
A
N
P
D
-
M
V
G
H
S
G
----------------------------------------------------------
K
L
E
P
T
I
K
A
V
E
A
V
D
E
C
L
G
K
V
V
D
A
I
L
A
----
K
G
G
I
A
I
I
T
A
D
H
G
N
A
D
E
V
L
T
P
D
----------
G
--
K
------------
P
Q
T
A
H
T
T
N
P
V
P
V
I
V
T
K
K
G
I
K
-------
L
R
-------
D
G
G
-------
I
L
G
D
L
A
P
T
M
L
D
L
L
G
L
P
Q
P
K
E
M
T
G
K
S
L
I
V
-
1
PsiBlast_PDB
95.64
80%
-83
- C4 -
1EJJ
3
GPMI_GEOSE
A:
[3-510]
--
K
K
P
V
A
L
I
I
L
D
G
F
A
L
R
D
E
T
Y
G
N
A
V
A
Q
A
N
K
P
N
F
D
R
Y
W
N
E
Y
P
H
-
T
-
T
L
K
A
C
G
E
A
V
G
L
P
-
E
G
Q
-
M
G
N
S
E
V
G
H
L
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
I
A
I
R
E
G
E
F
D
R
N
E
T
F
L
A
A
M
N
H
V
K
Q
H
G
T
S
L
H
L
F
G
L
L
S
D
G
G
V
H
S
H
I
H
H
L
Y
A
L
L
R
L
A
A
K
E
G
V
K
R
V
Y
I
H
G
F
L
D
G
R
D
V
G
P
Q
T
A
P
Q
Y
I
K
E
L
Q
---
E
---
K
I
K
E
Y
G
-
V
---
G
E
I
A
T
L
S
G
-
R
Y
Y
-
S
M
D
R
-
D
-
K
R
W
D
R
V
E
K
A
Y
R
A
M
V
Y
G
E
G
P
T
Y
R
D
P
L
E
C
I
E
---
D
S
Y
K
H
--
G
--
I
Y
D
E
F
V
L
P
S
V
I
V
R
E
D
G
R
P
V
A
T
I
Q
D
N
D
A
I
I
F
Y
N
F
R
P
D
R
A
I
Q
I
S
N
T
F
T
N
E
D
F
R
E
F
D
R
G
P
K
-
H
P
K
H
L
F
F
V
C
L
T
H
F
S
E
T
-
V
--
A
G
Y
V
A
F
K
P
T
N
L
D
N
T
I
G
E
V
L
S
Q
H
G
L
R
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
F
F
M
S
G
G
R
E
E
E
F
P
--
G
E
D
R
I
L
I
N
S
P
K
-
V
P
T
Y
D
L
K
P
E
M
S
A
Y
E
V
T
D
A
L
L
K
E
I
E
--
A
D
K
Y
D
A
I
I
L
N
Y
A
N
P
D
-
M
V
G
H
S
G
----------------------------------------------------------
K
L
E
P
T
I
K
A
V
E
A
V
D
E
C
L
G
K
V
V
D
A
I
L
A
----
K
G
G
I
A
I
I
T
A
D
H
G
N
A
D
E
V
L
T
P
D
----------
G
--
K
------------
P
Q
T
A
H
T
T
N
P
V
P
V
I
V
T
K
K
G
I
K
-------
L
R
-------
D
G
G
-------
I
L
G
D
L
A
P
T
M
L
D
L
L
G
L
P
Q
P
K
E
M
T
G
K
S
L
I
V
-
4
PsiBlast_PDB
95.58
80%
-80
- C4 -
1O99
8
GPMI_GEOSE
A:
[2-511]
-
S
K
K
P
V
A
L
I
I
L
D
G
F
A
L
R
D
E
T
Y
G
N
A
V
A
Q
A
N
K
P
N
F
D
R
Y
W
N
E
Y
P
H
-
T
-
T
L
K
A
C
G
E
A
V
G
L
P
-
E
G
Q
-
M
G
N
A
E
V
G
H
L
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
I
A
I
R
E
G
E
F
D
R
N
E
T
F
L
A
A
M
N
H
V
K
Q
H
G
T
S
L
H
L
F
G
L
L
S
D
G
G
V
H
S
H
I
H
H
L
Y
A
L
L
R
L
A
A
K
E
G
V
K
R
V
Y
I
H
G
F
L
D
G
R
D
V
G
P
Q
T
A
P
Q
Y
I
K
E
L
Q
---
E
---
K
I
K
E
Y
G
-
V
---
G
E
I
A
T
L
S
G
-
R
Y
Y
-
S
M
D
R
-
D
-
K
R
W
D
R
V
E
K
A
Y
R
A
M
V
Y
G
E
G
P
T
Y
R
D
P
L
E
C
I
E
---
D
S
Y
K
H
--
G
--
I
Y
D
E
F
V
L
P
S
V
I
V
R
E
D
G
R
P
V
A
T
I
Q
D
N
D
A
I
I
F
Y
N
F
R
P
D
R
A
I
Q
I
S
N
T
F
T
N
E
D
F
R
E
F
D
R
G
P
K
-
H
P
K
H
L
F
F
V
C
L
T
H
F
S
E
T
-
V
--
A
G
Y
V
A
F
K
P
T
N
L
D
N
T
I
G
E
V
L
S
Q
H
G
L
R
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
F
F
M
S
G
G
R
E
E
E
F
P
--
G
E
D
R
I
L
I
N
S
P
K
-
V
P
T
Y
D
L
K
P
E
M
S
A
Y
E
V
T
D
A
L
L
K
E
I
E
--
A
D
K
Y
D
A
I
I
L
N
Y
A
N
P
D
-
M
V
G
H
S
G
----------------------------------------------------------
K
L
E
P
T
I
K
A
V
E
A
V
D
E
C
L
G
K
V
V
D
A
I
L
A
----
K
G
G
I
A
I
I
T
A
D
H
G
N
A
D
E
V
L
T
P
D
----------
G
--
K
------------
P
Q
T
A
H
T
T
N
P
V
P
V
I
V
T
K
K
G
I
K
-------
L
R
-------
D
G
G
-------
I
L
G
D
L
A
P
T
M
L
D
L
L
G
L
P
Q
P
K
E
M
T
G
K
S
L
I
V
K
2
PsiBlast_PDB
95.50
80%
-81
- C4 -
1EQJ
3
GPMI_GEOSE
A:
[3-510]
--
K
K
P
V
A
L
I
I
L
D
G
F
A
L
R
D
E
T
Y
G
N
A
V
A
Q
A
N
K
P
N
F
D
R
Y
W
N
E
Y
P
H
-
T
-
T
L
K
A
C
G
E
A
V
G
L
P
-
E
G
Q
-
M
G
N
S
E
V
G
H
L
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
I
A
I
R
E
G
E
F
D
R
N
E
T
F
L
A
A
M
N
H
V
K
Q
H
G
T
S
L
H
L
F
G
L
L
S
D
G
G
V
H
S
H
I
H
H
L
Y
A
L
L
R
L
A
A
K
E
G
V
K
R
V
Y
I
H
G
F
L
D
G
R
D
V
G
P
Q
T
A
P
Q
Y
I
K
E
L
Q
---
E
---
K
I
K
E
Y
G
-
V
---
G
E
I
A
T
L
S
G
-
R
Y
Y
-
S
M
D
R
-
D
-
K
R
W
D
R
V
E
K
A
Y
R
A
M
V
Y
G
E
G
P
T
Y
R
D
P
L
E
C
I
E
---
D
S
Y
K
H
--
G
--
I
Y
D
E
F
V
L
P
S
V
I
V
R
E
D
G
R
P
V
A
T
I
Q
D
N
D
A
I
I
F
Y
N
F
R
P
D
R
A
I
Q
I
S
N
T
F
T
N
E
D
F
R
E
F
D
R
G
P
K
-
H
P
K
H
L
F
F
V
C
L
T
H
F
S
E
T
-
V
--
A
G
Y
V
A
F
K
P
T
N
L
D
N
T
I
G
E
V
L
S
Q
H
G
L
R
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
F
F
M
S
G
G
R
E
E
E
F
P
--
G
E
D
R
I
L
I
N
S
P
K
-
V
P
T
Y
D
L
K
P
E
M
S
A
Y
E
V
T
D
A
L
L
K
E
I
E
--
A
D
K
Y
D
A
I
I
L
N
Y
A
N
P
D
-
M
V
G
H
S
G
----------------------------------------------------------
K
L
E
P
T
I
K
A
V
E
A
V
D
E
C
L
G
K
V
V
D
A
I
L
A
----
K
G
G
I
A
I
I
T
A
D
H
G
N
A
D
E
V
L
T
P
D
----------
G
--
K
------------
P
Q
T
A
H
T
T
N
P
V
P
V
I
V
T
K
K
G
I
K
-------
L
R
-------
D
G
G
-------
I
L
G
D
L
A
P
T
M
L
D
L
L
G
L
P
Q
P
K
E
M
T
G
K
S
L
I
V
-
5
PsiBlast_PDB
93.65
78%
-91
- C4 -
2IFY
2
GPMI_BACAN
A:
[1-508]
--
R
K
P
T
A
L
I
I
L
D
G
F
G
L
R
E
E
T
Y
G
N
A
V
A
Q
A
K
K
P
N
F
D
G
Y
W
N
K
F
P
H
-
T
-
T
L
T
A
C
G
E
A
V
G
L
P
-
E
G
Q
-
M
G
N
S
E
V
G
H
L
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
V
N
V
A
I
R
E
G
E
F
D
K
N
E
T
F
Q
S
A
I
K
S
V
K
E
K
G
T
A
L
H
L
F
G
L
L
S
D
G
G
V
H
S
H
M
N
H
M
F
A
L
L
R
L
A
A
K
E
G
V
E
K
V
Y
I
H
A
F
L
D
G
R
D
V
G
P
K
T
A
Q
S
Y
I
D
A
T
N
---
E
---
V
I
K
E
T
G
-
V
---
G
Q
F
A
T
I
S
G
-
R
Y
Y
-
S
M
D
R
-
D
-
K
R
W
D
R
V
E
K
C
Y
R
A
M
V
N
G
E
G
P
T
Y
K
S
A
E
E
C
V
E
---
D
S
Y
A
N
--
G
--
I
Y
D
E
F
V
L
P
S
V
I
V
N
E
D
N
T
P
V
A
T
I
N
D
D
D
A
V
I
F
Y
N
F
R
P
D
R
A
I
Q
I
A
R
V
F
T
N
G
D
F
R
E
F
D
R
G
E
K
-
V
P
H
I
P
E
F
V
C
M
T
H
F
S
E
T
-
V
--
D
G
Y
V
A
F
K
P
M
N
L
D
N
T
L
G
E
V
V
A
Q
A
G
L
K
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
F
F
F
S
G
G
R
E
A
E
F
P
--
G
E
E
R
I
L
I
N
S
P
K
-
V
A
T
Y
D
L
K
P
E
M
S
I
Y
E
V
T
D
A
L
V
N
E
I
E
--
N
D
K
H
D
V
I
I
L
N
F
A
N
C
D
-
M
V
G
H
S
G
----------------------------------------------------------
M
M
E
P
T
I
K
A
V
E
A
T
D
E
C
L
G
K
V
V
E
A
I
L
A
----
K
D
G
V
A
L
I
T
A
D
H
G
N
A
D
E
E
L
T
S
E
----------
G
--
E
------------
P
M
T
A
H
T
T
N
P
V
P
F
I
V
T
K
N
D
V
E
-------
L
R
-------
E
D
G
-------
I
L
G
D
I
A
P
T
M
L
T
L
L
G
V
E
Q
P
K
E
M
T
G
K
T
I
I
K
-
23
HHSearch
86.01
81%
-43
- C4 -
1O98
9
GPMI_GEOSE
A:
[2-510]
-
S
K
K
P
V
A
L
I
I
L
D
G
F
A
L
R
D
E
T
Y
G
N
A
V
A
Q
A
N
K
P
N
F
D
R
Y
W
N
E
Y
P
H
-
T
-
T
L
K
A
C
G
E
A
V
G
L
P
-
E
G
Q
-
M
G
N
S
E
V
G
H
L
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
I
A
I
R
E
G
E
F
D
R
N
E
T
F
L
A
A
M
N
H
V
K
Q
H
G
T
S
L
H
L
F
G
L
L
S
D
G
G
V
H
S
H
I
H
H
L
Y
A
L
L
R
L
A
A
K
E
G
V
K
R
V
Y
I
H
G
F
L
D
G
R
D
V
G
P
Q
T
A
P
Q
Y
I
K
E
L
Q
---
E
---
K
I
K
E
Y
G
-
V
---
G
E
I
A
T
L
S
G
-
R
Y
Y
-
S
M
D
R
-
D
-
K
R
W
D
R
V
E
K
A
Y
R
A
M
V
Y
G
E
G
P
T
Y
R
D
P
L
E
C
I
E
---
D
S
Y
K
H
--
G
--
I
Y
D
E
F
V
L
P
S
V
I
V
R
E
D
G
R
P
V
A
T
I
Q
D
N
D
A
I
I
F
Y
N
F
R
P
D
R
A
I
Q
I
S
N
T
F
T
N
E
D
F
R
E
F
D
R
G
-
P
K
H
P
K
H
L
F
F
V
C
L
T
H
F
S
E
T
-
V
--
A
G
Y
V
A
F
K
P
T
N
L
D
N
T
I
G
E
V
L
S
Q
H
G
L
R
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
F
F
M
S
G
G
R
E
E
E
F
P
--
G
E
D
R
I
L
I
N
S
P
K
-
V
P
T
Y
D
L
K
P
E
M
S
A
Y
E
V
T
D
A
L
L
K
E
I
E
--
A
D
K
Y
D
A
I
I
L
N
Y
A
N
P
D
-
M
V
G
H
S
G
----------------------------------------------------------
K
L
E
P
T
I
K
A
V
E
A
V
D
E
C
L
G
K
V
V
D
A
I
L
A
----
K
G
G
I
A
I
I
T
A
D
H
G
N
A
D
E
V
L
T
P
D
----------
G
--
K
------------
P
Q
T
A
H
T
T
N
P
V
P
V
I
V
T
K
K
G
I
K
-------
L
R
-------
D
G
G
-------
I
L
G
D
L
A
P
T
M
L
D
L
L
G
L
P
Q
P
K
E
M
T
G
K
S
L
I
V
-
22
HHSearch
85.15
63%
-83
- C4 -
4MY4
2
?
A:
[11-513]
--
K
K
P
T
A
L
I
I
L
D
G
F
A
N
R
E
S
E
H
G
N
A
V
K
L
A
N
K
P
N
F
D
R
Y
Y
N
K
Y
P
T
-
T
-
Q
I
E
A
S
G
L
D
V
G
L
P
-
E
G
Q
-
M
G
N
S
E
V
G
H
M
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
K
S
I
E
D
G
D
F
F
E
N
D
V
L
N
N
A
I
A
H
V
N
S
H
D
S
A
L
H
I
F
G
L
L
S
D
G
G
V
H
S
H
Y
K
H
L
F
A
L
L
E
L
A
K
K
Q
G
V
E
K
V
Y
V
H
A
F
L
D
G
R
D
V
D
Q
K
S
A
L
K
Y
I
E
E
T
E
---
A
---
K
F
N
E
L
G
-
I
---
G
Q
F
A
S
V
S
G
-
R
Y
Y
-
A
M
D
R
-
D
-
K
R
W
E
R
E
E
K
A
Y
N
A
I
R
N
F
D
A
P
T
Y
A
T
A
K
E
G
V
E
---
A
S
Y
N
E
--
G
--
L
T
D
E
F
V
V
P
F
I
V
E
N
Q
N
D
----
G
V
N
D
G
D
A
V
I
F
Y
N
F
R
P
D
R
A
A
Q
L
S
E
I
F
A
N
R
A
F
E
G
F
K
V
--
E
-
Q
V
K
D
L
F
Y
A
T
F
T
K
Y
N
D
N
-
I
--
D
A
A
I
V
F
E
K
V
D
L
N
N
T
I
G
E
I
A
Q
N
N
N
L
T
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
Y
F
M
S
G
G
R
N
E
E
F
K
--
G
E
R
R
R
L
I
D
S
P
K
-
V
A
T
Y
D
L
K
P
E
M
S
A
Y
E
V
K
D
A
L
L
E
E
L
N
--
K
G
D
L
D
L
I
I
L
N
F
A
N
P
D
-
M
V
G
H
S
G
----------------------------------------------------------
M
L
E
P
T
I
K
A
I
E
A
V
D
E
C
L
G
E
V
V
D
K
I
L
D
----
M
D
G
Y
A
I
I
T
A
D
H
G
N
S
D
Q
V
L
T
D
D
----------
D
--
Q
------------
P
M
T
T
H
T
T
N
P
V
P
V
I
V
T
K
E
G
V
T
-------
L
R
-------
E
T
G
-------
R
L
G
D
L
A
P
T
L
L
D
L
L
N
V
E
Q
P
E
D
M
T
G
E
S
L
I
K
H
8
PsiBlast_PDB
84.52
62%
-83
- C4 -
4NWX
4
?
A:
[11-512]
--
K
K
P
T
A
L
I
I
L
D
G
F
A
N
R
E
S
E
H
G
N
A
V
K
L
A
N
K
P
N
F
D
R
Y
Y
N
K
Y
P
T
-
T
-
Q
I
E
A
S
G
L
D
V
G
L
P
-
E
G
Q
-
M
G
N
S
E
V
G
H
M
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
K
S
I
E
D
G
D
F
F
E
N
D
V
L
N
N
A
I
A
H
V
N
S
H
D
S
A
L
H
I
F
G
L
L
S
D
G
G
V
H
S
H
Y
K
H
L
F
A
L
L
E
L
A
K
K
Q
G
V
E
K
V
Y
V
H
A
F
L
D
G
R
D
V
D
Q
K
S
A
L
K
Y
I
E
E
T
E
---
A
---
K
F
N
E
L
G
-
I
---
G
Q
F
A
S
V
S
G
-
R
Y
Y
-
A
M
D
R
-
D
-
K
R
W
E
R
E
E
K
A
Y
N
A
I
R
N
F
D
A
P
T
Y
A
T
A
K
E
G
V
E
---
A
S
Y
N
E
--
G
--
L
T
D
E
F
V
V
P
F
I
V
E
N
Q
N
D
----
G
V
N
D
G
D
A
V
I
F
Y
N
F
R
P
D
R
A
A
Q
L
S
E
I
F
A
N
R
A
F
E
G
F
K
V
E
Q
---
V
K
D
L
F
Y
A
T
F
T
K
Y
N
D
N
-
I
--
D
A
A
I
V
F
E
K
V
D
L
N
N
T
I
G
E
I
A
Q
N
N
N
L
T
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
Y
F
M
S
G
G
R
N
E
E
F
K
--
G
E
R
R
R
L
I
D
S
P
K
-
V
A
T
Y
D
L
K
P
E
M
S
A
Y
E
V
K
D
A
L
L
E
E
L
N
--
K
G
D
L
D
L
I
I
L
N
F
A
N
P
D
-
M
V
G
H
S
G
----------------------------------------------------------
M
L
E
P
T
I
K
A
I
E
A
V
D
E
C
L
G
E
V
V
D
K
I
L
D
----
M
D
G
Y
A
I
I
T
A
D
H
G
N
S
D
Q
V
L
T
D
D
----------
D
--
Q
------------
P
M
T
T
H
T
T
N
P
V
P
V
I
V
T
K
E
G
V
T
-------
L
R
-------
E
T
G
-------
R
L
G
D
L
A
P
T
L
L
D
L
L
N
V
E
Q
P
E
D
M
T
G
E
S
L
I
K
-
9
PsiBlast_PDB
84.23
62%
-81
- C4 -
4QAX
3
?
A:
[11-512]
--
K
K
P
T
A
L
I
I
L
D
G
F
A
N
R
E
S
E
H
G
N
A
V
K
L
A
N
K
P
N
F
D
R
Y
Y
N
K
Y
P
T
-
T
-
Q
I
E
A
S
G
L
D
V
G
L
P
-
E
G
Q
-
M
G
N
S
E
V
G
H
M
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
K
S
I
E
D
G
D
F
F
E
N
D
V
L
N
N
A
I
A
H
V
N
S
H
D
S
A
L
H
I
F
G
L
L
S
D
G
G
V
H
S
H
Y
K
H
L
F
A
L
L
E
L
A
K
K
Q
G
V
E
K
V
Y
V
H
A
F
L
D
G
R
D
V
D
Q
K
S
A
L
K
Y
I
E
E
T
E
---
A
---
K
F
N
E
L
G
-
I
---
G
Q
F
A
S
V
S
G
-
R
Y
Y
-
A
M
D
R
-
D
-
K
R
W
E
R
E
E
K
A
Y
N
A
I
R
N
F
D
A
P
T
Y
A
T
A
K
E
G
V
E
---
A
S
Y
N
E
--
G
--
L
T
D
E
F
V
V
P
F
I
V
E
N
Q
N
D
----
G
V
N
D
G
D
A
V
I
F
Y
N
F
R
P
D
R
A
A
Q
L
S
E
I
F
A
N
R
A
F
E
G
F
K
V
E
Q
---
V
K
D
L
F
Y
A
T
F
T
K
Y
N
D
N
-
I
--
D
A
A
I
V
F
E
K
V
D
L
N
N
T
I
G
E
I
A
Q
N
N
N
L
T
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
Y
F
M
S
G
G
R
N
E
E
F
K
--
G
E
R
R
R
L
I
D
S
P
K
-
V
A
T
Y
D
L
K
P
E
M
S
A
Y
E
V
K
D
A
L
L
E
E
L
N
--
K
G
D
L
D
L
I
I
L
N
F
A
N
P
D
-
M
V
G
H
S
G
----------------------------------------------------------
M
L
E
P
T
I
K
A
I
E
A
V
D
E
C
L
G
E
V
V
D
K
I
L
D
----
M
D
G
Y
A
I
I
T
A
D
H
G
N
S
D
Q
V
L
T
D
D
----------
D
--
Q
------------
P
M
T
T
H
T
T
N
P
V
P
V
I
V
T
K
E
G
V
T
-------
L
R
-------
E
T
G
-------
R
L
G
D
L
A
P
T
L
L
D
L
L
N
V
E
Q
P
E
D
M
T
G
E
S
L
I
K
-
6
PsiBlast_PDB
84.10
62%
-82
- C4 -
4MY4
2
?
A:
[11-512]
--
K
K
P
T
A
L
I
I
L
D
G
F
A
N
R
E
S
E
H
G
N
A
V
K
L
A
N
K
P
N
F
D
R
Y
Y
N
K
Y
P
T
-
T
-
Q
I
E
A
S
G
L
D
V
G
L
P
-
E
G
Q
-
M
G
N
S
E
V
G
H
M
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
K
S
I
E
D
G
D
F
F
E
N
D
V
L
N
N
A
I
A
H
V
N
S
H
D
S
A
L
H
I
F
G
L
L
S
D
G
G
V
H
S
H
Y
K
H
L
F
A
L
L
E
L
A
K
K
Q
G
V
E
K
V
Y
V
H
A
F
L
D
G
R
D
V
D
Q
K
S
A
L
K
Y
I
E
E
T
E
---
A
---
K
F
N
E
L
G
-
I
---
G
Q
F
A
S
V
S
G
-
R
Y
Y
-
A
M
D
R
-
D
-
K
R
W
E
R
E
E
K
A
Y
N
A
I
R
N
F
D
A
P
T
Y
A
T
A
K
E
G
V
E
---
A
S
Y
N
E
--
G
--
L
T
D
E
F
V
V
P
F
I
V
E
N
Q
N
D
----
G
V
N
D
G
D
A
V
I
F
Y
N
F
R
P
D
R
A
A
Q
L
S
E
I
F
A
N
R
A
F
E
G
F
K
V
E
Q
---
V
K
D
L
F
Y
A
T
F
T
K
Y
N
D
N
-
I
--
D
A
A
I
V
F
E
K
V
D
L
N
N
T
I
G
E
I
A
Q
N
N
N
L
T
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
Y
F
M
S
G
G
R
N
E
E
F
K
--
G
E
R
R
R
L
I
D
S
P
K
-
V
A
T
Y
D
L
K
P
E
M
S
A
Y
E
V
K
D
A
L
L
E
E
L
N
--
K
G
D
L
D
L
I
I
L
N
F
A
N
P
D
-
M
V
G
H
S
G
----------------------------------------------------------
M
L
E
P
T
I
K
A
I
E
A
V
D
E
C
L
G
E
V
V
D
K
I
L
D
----
M
D
G
Y
A
I
I
T
A
D
H
G
N
S
D
Q
V
L
T
D
D
----------
D
--
Q
------------
P
M
T
T
H
T
T
N
P
V
P
V
I
V
T
K
E
G
V
T
-------
L
R
-------
E
T
G
-------
R
L
G
D
L
A
P
T
L
L
D
L
L
N
V
E
Q
P
E
D
M
T
G
E
S
L
I
K
-
7
PsiBlast_PDB
83.94
62%
-82
- C4 -
4NWJ
3
?
A:
[10-512]
-
A
K
K
P
T
A
L
I
I
L
D
G
F
A
N
R
E
S
E
H
G
N
A
V
K
L
A
N
K
P
N
F
D
R
Y
Y
N
K
Y
P
T
-
T
-
Q
I
E
A
S
G
L
D
V
G
L
P
-
E
G
Q
-
M
G
N
S
E
V
G
H
M
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
K
S
I
E
D
G
D
F
F
E
N
D
V
L
N
N
A
I
A
H
V
N
S
H
D
S
A
L
H
I
F
G
L
L
S
D
G
G
V
H
S
H
Y
K
H
L
F
A
L
L
E
L
A
K
K
Q
G
V
E
K
V
Y
V
H
A
F
L
D
G
R
D
V
D
Q
K
S
A
L
K
Y
I
E
E
T
E
---
A
---
K
F
N
E
L
G
-
I
---
G
Q
F
A
S
V
S
G
-
R
Y
Y
-
A
M
D
R
-
D
-
K
R
W
E
R
E
E
K
A
Y
N
A
I
R
N
F
D
A
P
T
Y
A
T
A
K
E
G
V
E
---
A
S
Y
N
E
--
G
--
L
T
D
E
F
V
V
P
F
I
V
E
N
Q
N
D
----
G
V
N
D
G
D
A
V
I
F
Y
N
F
R
P
D
R
A
A
Q
L
S
E
I
F
A
N
R
A
F
E
G
F
K
V
E
Q
---
V
K
D
L
F
Y
A
T
F
T
K
Y
N
D
N
-
I
--
D
A
A
I
V
F
E
K
V
D
L
N
N
T
I
G
E
I
A
Q
N
N
N
L
T
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
Y
F
M
S
G
G
R
N
E
E
F
K
--
G
E
R
R
R
L
I
D
S
P
K
-
V
A
T
Y
D
L
K
P
E
M
S
A
Y
E
V
K
D
A
L
L
E
E
L
N
--
K
G
D
L
D
L
I
I
L
N
F
A
N
P
D
-
M
V
G
H
S
G
----------------------------------------------------------
M
L
E
P
T
I
K
A
I
E
A
V
D
E
C
L
G
E
V
V
D
K
I
L
D
----
M
D
G
Y
A
I
I
T
A
D
H
G
N
S
D
Q
V
L
T
D
D
----------
D
--
Q
------------
P
M
T
T
H
T
T
N
P
V
P
V
I
V
T
K
E
G
V
T
-------
L
R
-------
E
T
G
-------
R
L
G
D
L
A
P
T
L
L
D
L
L
N
V
E
Q
P
E
D
M
T
G
E
S
L
I
K
-
24
HHSearch
55.25
32%
36
- C4 -
3IGZ
4
?
B:
[12-551]
L
P
R
R
T
V
L
I
V
V
M
D
G
L
G
I
G
P
E
D
D
Y
D
A
V
H
M
A
S
T
P
F
M
D
A
H
R
R
D
N
R
H
-
F
R
C
V
R
A
H
G
T
A
V
G
L
P
-
T
D
A
D
M
G
N
S
E
V
G
H
N
A
L
G
A
G
R
V
A
L
Q
G
A
S
L
V
D
D
A
I
K
S
G
E
I
Y
T
G
E
G
Y
R
Y
L
H
G
A
F
S
K
E
G
S
T
L
H
L
I
G
L
L
S
D
G
G
V
H
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R
D
N
Q
I
Y
S
I
I
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H
A
V
K
D
G
A
K
R
I
R
V
H
A
L
Y
D
G
R
D
V
P
D
G
S
S
F
R
F
T
D
E
L
E
---
A
---
V
L
A
K
V
R
Q
N
GCD
A
A
I
A
S
G
G
G
R
M
F
V
-
T
M
D
R
-
Y
D
A
D
W
S
I
V
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R
G
W
R
A
Q
V
L
G
D
A
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H
F
H
S
A
K
E
A
I
T
---
T
F
R
E
E
DP
K
--
V
T
D
Q
Y
Y
P
P
F
I
V
V
D
E
Q
D
K
P
L
G
T
I
E
D
G
D
A
V
L
C
V
N
F
R
G
D
R
V
I
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M
T
R
A
F
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D
E
D
F
N
K
F
D
R
V
---
R
V
P
K
V
R
Y
A
G
M
M
R
Y
D
G
D
-
L
GI
P
N
N
F
L
V
P
P
P
K
L
T
R
V
S
E
E
Y
L
C
G
S
G
L
N
I
F
A
C
S
E
T
Q
K
F
G
H
V
T
Y
F
W
N
G
N
R
S
G
K
I
D
EK
H
E
T
F
K
E
V
P
S
D
R
-
V
-
Q
F
N
E
K
P
R
M
Q
S
A
A
I
T
E
A
A
I
E
A
L
K
--
S
G
M
Y
N
V
V
R
I
N
F
P
N
G
D
-
M
V
G
H
T
G
----------------------------------------------------------
D
L
K
A
T
I
T
G
V
E
A
V
D
E
S
L
A
K
L
K
D
A
V
D
S
----
V
N
G
V
Y
I
V
T
A
D
H
G
N
S
D
D
M
A
Q
R
D
KKGKPMKDGN
G
NV
L
------------
P
L
T
S
H
T
L
S
P
V
P
V
F
I
G
G
A
G
L
D
PRVAMRT
D
L
-------
P
A
A
-------
G
L
A
N
V
T
A
T
F
I
N
L
L
G
F
E
A
P
E
D
Y
E
P
S
L
I
Y
V
-
11
PsiBlast_PDB
54.73
31%
36
- C4 -
3IGY
4
?
B:
[12-543]
L
P
R
R
T
V
L
I
V
V
M
D
G
L
G
I
G
P
E
D
D
Y
D
A
V
H
M
A
S
T
P
F
M
D
A
H
R
R
D
N
R
H
F
R
-
C
V
R
A
H
G
T
A
V
G
L
P
T
D
A
D
-
M
G
N
S
E
V
G
H
N
A
L
G
A
G
R
V
A
L
Q
G
A
S
L
V
D
D
A
I
K
S
G
E
I
Y
T
G
E
G
Y
R
Y
L
H
G
A
F
S
K
E
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S
T
L
H
L
I
G
L
L
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D
G
G
V
H
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R
D
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Q
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I
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A
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K
D
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A
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L
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D
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P
D
G
S
S
F
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F
T
D
E
L
E
AVL
A
---
K
V
R
Q
N
G
-
C
D--
A
A
I
A
S
G
G
G
-
R
M
F
V
T
M
D
R
Y
D
-
A
D
W
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G
W
R
A
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V
L
G
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A
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F
H
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A
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---
T
F
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E
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--
D
PK
V
T
D
Q
Y
Y
P
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V
V
D
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Q
D
K
P
L
G
T
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D
G
D
A
V
L
C
V
N
F
R
G
D
R
V
I
E
M
T
R
A
F
E
D
E
D
F
N
K
F
D
R
-
V
R
-
V
P
K
V
R
Y
A
G
M
M
R
Y
D
G
D
L
G
I
--
P
N
N
F
L
V
P
P
P
K
L
T
R
V
S
E
E
Y
L
C
G
S
G
L
N
I
F
A
C
S
E
T
Q
K
F
G
H
V
T
Y
F
W
N
G
N
R
S
G
K
I
D
--
E
K
H
E
T
F
K
E
V
P
S
D
R
V
Q
F
N
E
K
P
R
M
Q
S
A
A
I
T
E
A
A
I
E
A
L
K
--
S
G
M
Y
N
V
V
R
I
N
F
P
N
G
D
-
M
V
G
H
T
G
----------------------------------------------------------
D
L
K
A
T
I
T
G
V
E
A
V
D
E
S
L
A
K
L
K
D
A
V
D
S
----
V
N
G
V
Y
I
V
T
A
D
H
G
N
S
D
D
M
A
Q
R
D
----------
K
--
K
GKPMKDGNGNVL
P
L
T
S
H
T
L
S
P
V
P
V
F
I
G
G
A
G
L
D
-------
P
R
VAMRTDL
P
A
A
-------
G
L
A
N
V
T
A
T
F
I
N
L
L
G
F
E
A
P
E
D
---------
21
PsiBlast_CBE
54.50
33%
31
- C4 -
3NVL
3
?
B:
[31-562]
L
P
R
R
K
L
V
L
V
V
L
D
G
V
G
I
G
P
R
D
E
Y
D
A
V
H
V
A
K
T
P
L
M
D
A
L
F
N
D
P
K
H
F
R
-
S
I
C
A
H
G
T
A
V
G
L
P
T
D
A
D
-
M
G
N
S
E
V
G
H
N
A
L
G
A
G
R
V
V
L
Q
G
A
S
L
V
D
D
A
L
E
S
G
E
I
F
T
S
E
G
Y
R
Y
L
H
G
A
F
S
Q
P
G
R
T
L
H
L
I
G
L
L
S
D
G
G
V
H
S
R
D
N
Q
V
Y
Q
I
L
K
H
A
G
A
N
G
A
K
R
I
R
V
H
A
L
Y
D
G
R
D
V
P
D
K
T
S
F
K
F
T
D
E
L
E
---
E
VLA
K
L
R
E
G
G
-
C
D--
A
R
I
A
S
G
G
G
-
R
M
F
V
T
M
D
R
Y
E
-
A
D
W
S
I
V
E
R
G
W
R
A
Q
V
L
G
E
G
R
A
F
K
S
A
R
E
A
L
T
KFR
E
E
D
A
N
-----
I
S
D
Q
Y
Y
P
P
F
V
I
A
G
D
D
G
R
P
I
G
T
I
E
D
G
D
A
V
L
C
F
N
F
R
G
D
R
V
I
E
M
S
R
A
F
E
E
E
E
F
D
K
F
N
R
-
V
R
-
L
P
K
V
R
Y
A
G
M
M
R
Y
D
G
D
L
G
I
--
P
N
N
F
L
V
P
P
P
K
L
T
R
T
S
E
E
Y
L
I
G
S
G
C
N
I
F
A
L
S
E
T
Q
K
F
G
H
V
T
Y
F
W
N
G
N
R
S
G
K
L
S
--
E
E
R
E
T
F
C
E
I
P
S
D
R
V
Q
F
N
Q
K
P
L
M
K
S
K
E
I
T
D
A
A
V
D
A
I
K
--
S
G
K
Y
D
M
I
R
I
N
Y
P
N
G
D
-
M
V
G
H
T
G
----------------------------------------------------------
D
L
K
A
T
I
T
S
L
E
A
V
D
Q
S
L
Q
R
L
K
E
A
V
D
S
----
V
N
G
V
F
L
I
T
A
D
H
G
N
S
D
D
M
V
Q
R
D
----------
K
--
K
GKPVRDAEGNLM
P
L
T
S
H
T
L
A
P
V
P
V
F
I
G
G
A
G
L
D
-------
P
R
VQMRTDL
P
R
A
-------
G
L
A
N
V
T
A
T
F
I
N
L
M
G
F
E
A
P
S
D
---------
12
PsiBlast_PDB
54.46
31%
34
- C4 -
3IGZ
4
?
B:
[12-543]
L
P
R
R
T
V
L
I
V
V
M
D
G
L
G
I
G
P
E
D
D
Y
D
A
V
H
M
A
S
T
P
F
M
D
A
H
R
R
D
N
R
H
F
R
-
C
V
R
A
H
G
T
A
V
G
L
P
T
D
A
D
-
M
G
N
S
E
V
G
H
N
A
L
G
A
G
R
V
A
L
Q
G
A
S
L
V
D
D
A
I
K
S
G
E
I
Y
T
G
E
G
Y
R
Y
L
H
G
A
F
S
K
E
G
S
T
L
H
L
I
G
L
L
S
D
G
G
V
H
S
R
D
N
Q
I
Y
S
I
I
E
H
A
V
K
D
G
A
K
R
I
R
V
H
A
L
Y
D
G
R
D
V
P
D
G
S
S
F
R
F
T
D
E
L
E
AVL
A
---
K
V
R
Q
N
G
-
C
D--
A
A
I
A
S
G
G
G
-
R
M
F
V
T
M
D
R
Y
D
-
A
D
W
S
I
V
E
R
G
W
R
A
Q
V
L
G
D
A
R
H
F
H
S
A
K
E
A
I
T
---
T
F
R
E
E
--
D
PK
V
T
D
Q
Y
Y
P
P
F
I
V
V
D
E
Q
D
K
P
L
G
T
I
E
D
G
D
A
V
L
C
V
N
F
R
G
D
R
V
I
E
M
T
R
A
F
E
D
E
D
F
N
K
F
D
R
-
V
R
-
V
P
K
V
R
Y
A
G
M
M
R
Y
D
G
D
L
G
I
--
P
N
N
F
L
V
P
P
P
K
L
T
R
V
S
E
E
Y
L
C
G
S
G
L
N
I
F
A
C
S
E
T
Q
K
F
G
H
V
T
Y
F
W
N
G
N
R
S
G
K
I
D
--
E
K
H
E
T
F
K
E
V
P
S
D
R
V
Q
F
N
E
K
P
R
M
Q
S
A
A
I
T
E
A
A
I
E
A
L
K
--
S
G
M
Y
N
V
V
R
I
N
F
P
N
G
D
-
M
V
G
H
T
G
----------------------------------------------------------
D
L
K
A
T
I
T
G
V
E
A
V
D
E
S
L
A
K
L
K
D
A
V
D
S
----
V
N
G
V
Y
I
V
T
A
D
H
G
N
S
D
D
M
A
Q
R
D
----------
K
--
K
GKPMKDGNGNVL
P
L
T
S
H
T
L
S
P
V
P
V
F
I
G
G
A
G
L
D
-------
P
R
VAMRTDL
P
A
A
-------
G
L
A
N
V
T
A
T
F
I
N
L
L
G
F
E
A
P
E
D
---------
10
PsiBlast_PDB
53.92
33%
28
- C4 -
3NVL
3
?
A:
[31-562]
L
P
R
R
K
L
V
L
V
V
L
D
G
V
G
I
G
P
R
D
E
Y
D
A
V
H
V
A
K
T
P
L
M
D
A
L
F
N
D
P
K
H
F
R
-
S
I
C
A
H
G
T
A
V
G
L
P
T
D
A
D
-
M
G
N
S
E
V
G
H
N
A
L
G
A
G
R
V
V
L
Q
G
A
S
L
V
D
D
A
L
E
S
G
E
I
F
T
S
E
G
Y
R
Y
L
H
G
A
F
S
Q
P
G
R
T
L
H
L
I
G
L
L
S
D
G
G
V
H
S
R
D
N
Q
V
Y
Q
I
L
K
H
A
G
A
N
G
A
K
R
I
R
V
H
A
L
Y
D
G
R
D
V
P
D
K
T
S
F
K
F
T
D
E
L
E
---
E
V
L
A
K
L
R
E
G
G
-
C
D--
A
R
I
A
S
G
G
G
-
R
M
F
V
T
M
D
R
Y
E
-
A
D
W
S
I
V
E
R
G
W
R
A
Q
V
L
G
E
G
R
A
F
K
S
A
R
E
A
L
T
K
F
R
E
E
D
A
N
-----
I
S
D
Q
Y
Y
P
P
F
V
I
A
G
D
D
G
R
P
I
G
T
I
E
D
G
D
A
V
L
C
F
N
F
R
G
D
R
V
I
E
M
S
R
A
F
E
E
E
E
F
D
K
F
N
R
-
V
R
-
L
P
K
V
R
Y
A
G
M
M
R
Y
D
G
D
L
G
I
--
P
N
N
F
L
V
P
P
P
K
L
T
R
T
S
E
E
Y
L
I
G
S
G
C
N
I
F
A
L
S
E
T
Q
K
F
G
H
V
T
Y
F
W
N
G
N
R
S
G
K
L
S
--
E
E
R
E
T
F
C
E
I
P
S
D
R
V
Q
F
N
Q
K
P
L
M
K
S
K
E
I
T
D
A
A
V
D
A
I
K
--
S
G
K
Y
D
M
I
R
I
N
Y
P
N
G
D
-
M
V
G
H
T
G
----------------------------------------------------------
D
L
K
A
T
I
T
S
L
E
A
V
D
Q
S
L
Q
R
L
K
E
A
V
D
S
----
V
N
G
V
F
L
I
T
A
D
H
G
N
S
D
D
M
V
Q
R
D
----------
K
--
K
G
K
P
V
R
D
AEG
N
L
M
P
L
T
S
H
T
L
A
P
V
P
V
F
I
G
G
A
G
L
D
-------
P
R
V
Q
M
R
TDL
P
R
A
-------
G
L
A
N
V
T
A
T
F
I
N
L
M
G
F
E
A
P
S
D
---------
44
HHSearch
29.61
27%
-34
- C4 -
3OT9
6
DEOB_BACCR
A:
[226-395]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
T
V
M
N
E
L
K
D
S
D
Y
D
V
I
A
I
---
G
K
I
-
S
-
D
I
Y
D
G
E
G
V
T
E
S
L
----------------------
R
T
K
S
N
M
D
G
M
D
K
L
V
D
T
L
N
--
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
----------------------------------------------------------
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
A
K
L
K
E
-----
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
H
P
-------------
G
-----------------
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
S
M
K
EGGQE--
L
P
-------
L
R
Q
-------
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
--
Y
G
T
S
F
L
N
-
39
HHSearch
28.15
19%
-8
- C4 -
3B5Q
11
?
A:
[39-358]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
C
T
L
P
I
D
E
--------
V
A
S
R
--
G
V
I
F
S
N
A
Y
V
G
------
C
P
L
S
Q
P
S
R
A
A
L
W
S
G
-
M
-
M
P
H
Q
T
N
V
R
S
N
S
S
E
-------
P
V
N
T
R
L
P
--
E
N
V
P
T
L
G
S
L
F
S
E
S
G
Y
E
A
V
H
F
---
G
K
T
-
H
D
M
G
-
S
L
R
G
F
K
H
K
E
P
--
V
A
K
P
--
F
T
D
P
E
--
F
P
V
N
-
N
D
S
F
L
D
V
G
T
C
E
D
A
V
A
Y
L
S
NP
P
K
E
P
F
I
C
I
A
D
F
Q
N
P
H
-
N
I
C
G
F
I
G
E
N
A
G
V
H
T
D
RPISGPLPELPDNFDVEDWSNIP
T
P
V
Q
Y
I
CCSH
R
R
M
T
Q
A
A
HWN
E
E
N
Y
R
H
Y
I
A
A
F
Q
H
Y
T
K
M
V
S
K
Q
V
D
S
V
L
K
A
L
Y
S
T
P
A
G
R
N
T
I
V
V
I
M
A
D
H
G
D
G
M
A
S
H
R
M
V
----------
T
--
K
H-----------
I
S
F
Y
D
E
M
T
N
V
P
F
I
F
A
G
P
G
I
K
Q
Q
KKP--
V
D
-------
H
L
L
T
Q
-----
P
T
L
D
L
L
P
T
L
C
D
L
A
G
I
A
V
P
A
E
K
A
G
I
S
L
A
P
-
14
PsiBlast_PDB
27.05
29%
-47
- C4 -
3M8Y
7
DEOB_BACCR
A:
[269-396]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
L
V
D
T
L
N
--
M
D
F
T
G
L
S
F
L
N
L
V
D
F
D
A
L
F
G
H
R
R
----------------------------------------------------------
D
P
Q
G
Y
G
E
A
L
Q
E
Y
D
A
R
L
P
E
V
F
-
A
K
L
K
----
E
D
D
L
L
L
I
T
A
D
H
G
N
D
P
I
------------------
H
------------
P
G
T
D
H
T
R
E
Y
V
P
L
L
A
Y
S
P
--
S
-------
M
K
-------
E
G
G
QELPLRQ
T
F
A
D
I
G
A
T
V
A
E
N
F
G
V
K
M
P
E
--
Y
G
T
S
F
L
N
E