@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu33930: (2016-07-27 )
MNKKTLKDIDVKGKVVFCRVDFNVPMKDGEVTDDTRIRAALPTIKHLADQGAKVLLASHLGRPKGEVVEELRLTPVAARLGELLGKEVKKADEAYGDAVKAQISEMKDGDVLVLENVRFYPGEEKNDPELAKAFAELADVYVNDAFGAAHRAHASTAGIAEHLPAVAGFLMEKELDVLGKAVSNPDRPFTAIIGGAKVKDKIGVIESLLDKVDNLIIGGGLAYTFVKALGYEVGKSLLEEDKIELAKSFMDRAKEKGVNFYMPEDVLVADDFSNDANVKIVPISEIPSDLEAIDIGTKTRETYADVIKNSKLVVWNGPMGVFEIDLFAQGTKAVAEALAEAKDTYSVIGGGDSAAAVEKFGLADKMSHISTGGGASLEFMEGKELPGVAALNDK
Atome Classification :
(61 SA)
.........10........20.......-.-30........40........50.-.-......60..-.-.-..----------------.----------------.70.-.......-80........90....----.-...100.......110.......120--...----.-----------.--------------.-------..-------.130.-----------.----....-.-140.......150.......160.-.---.-.---.-.-.170.......180.......190.......200.......--210.........220.......-230.......240-----.........250.......260---........270.....-..-280..-..---....290.......300.......310.......320.......330......--.--340---.--..---....350.......360.......370.......380.......390..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNKKTLKDIDVK
G
K
V
V
F
C
R
V
D
FNVPMKD-G-EVTDD
T
R
I
R
A
A
L
P
T
I
K
H
L
A
DQ
G
A
-
K
-
V
L
L
A
S
HLGRP-
K
-
G
-
E
V
----------------
V
----------------
E
E
LR-L
T
P
V
A
A
R
-
L
G
E
L
L
G
K
E
V
K
K
A
D
E
A
Y----
G
-
D
A
V
K
A
Q
I
S
EMKDG
D
V
L
V
L
E
N
V
RFY----PGE----E-----------K--------------N-------
D
P
-------
E
L
A
K
A
-----------
F
----
A
E
L
A
-
D
-
V
Y
V
NDAFGA
A
H
R
AHASTA
G
I
A
E
H
L
-
P
---
A
-
V
---
A
-
G
-
F
L
M
E
K
E
L
D
V
L
G
K
AVSNPDR
P
F
T
A
I
IGGAK
V
K
D
K
I
G
V
I
E
S
L
L
--
D
--
K
VD
N
L
I
IG
G
G
L
A
Y
T
F
V
K
A
L
-
G
Y
E
V
G
K
S
L
L
E
E
-------
D
K
I
E
L
A
K
S
F
M
D
R
A
K
EKGV
N
F
Y----MPED
V
L
V
ADDFSNDA
N
-
V
K
-
I
-
V
PI-SE---IPSD
L
E
AIDIGT
K
T
R
E
T
Y
A
D
V
IKNS
K
L
V
V
WNGPM
G
V
F
E
I
D
L
FAQ
G
T
K
A
V
A
E
A
L
--
A
--EAK---D--
T
Y
---
S
V
IGGG
D
S
A
A
A
V
E
K
FG
L
A
D
K
M
S
HISTGGGA
S
L
E
FMEGKELPGVAALNDK
61
HHSearch
92.63
81%
-105
- C5 -
1PHP
2
PGK_GEOSE
A:
[1-394]
M
N
K
K
T
I
R
D
V
D
V
R
G
K
R
V
F
C
R
V
D
F
N
V
P
M
E
Q
-
G
-
A
I
T
D
D
T
R
I
R
A
A
L
P
T
I
R
Y
L
I
E
H
G
A
-
K
-
V
I
L
A
S
H
L
G
R
P
-
K
-
G
-
K
V
----------------
V
----------------
E
E
L
R
-
L
D
A
V
A
K
R
-
L
G
E
L
L
E
R
P
V
A
K
T
N
E
A
V
----
G
-
D
E
V
K
A
A
V
D
R
L
N
E
G
D
V
L
L
L
E
N
V
R
F
Y
----
P
G
E
----
E
-----------
K
--------------
N
-------
D
P
-------
E
L
A
K
A
-----------
F
----
A
E
L
A
-
D
-
L
Y
V
N
D
A
F
G
A
A
H
R
A
H
A
S
T
E
G
I
A
H
Y
L
-
P
---
A
-
V
---
A
-
G
-
F
L
M
E
K
E
L
E
V
L
G
K
A
L
S
N
P
D
R
P
F
T
A
I
I
G
G
A
K
V
K
D
K
I
G
V
I
D
N
L
L
--
E
--
K
V
D
N
L
I
I
G
G
G
L
A
Y
T
F
V
K
A
L
-
G
H
D
V
G
K
S
L
L
E
E
-------
D
K
I
E
L
A
K
S
F
M
E
K
A
K
E
K
G
V
R
F
Y
----
M
P
V
D
V
V
V
A
D
R
F
A
N
D
A
N
-
T
K
-
V
-
V
P
I
-
D
A
---
I
P
A
D
W
S
A
L
D
I
G
P
K
T
R
E
L
Y
R
D
V
I
R
E
S
K
L
V
V
W
N
G
P
M
G
V
F
E
M
D
A
F
A
H
G
T
K
A
I
A
E
A
L
--
A
--
E
A
L
---
D
--
T
Y
---
S
V
I
G
G
G
D
S
A
A
A
V
E
K
F
G
L
A
D
K
M
D
H
I
S
T
G
G
G
A
S
L
E
F
M
E
G
K
Q
L
P
G
V
V
A
L
E
D
K
1
PsiBlast_PDB
92.37
80%
-105
- C5 -
1PHP
2
PGK_GEOSE
A:
[1-394]
M
N
K
K
T
I
R
D
V
D
V
R
G
K
R
V
F
C
R
V
D
F
N
V
P
M
E
Q
-
G
-
A
I
T
D
D
T
R
I
R
A
A
L
P
T
I
R
Y
L
I
E
H
G
A
-
K
-
V
I
L
A
S
H
L
G
R
P
-
K
-
G
-
K
V
----------------
V
----------------
E
E
L
R
-
L
D
A
V
A
K
R
-
L
G
E
L
L
E
R
P
V
A
K
T
N
E
A
V
----
G
-
D
E
V
K
A
A
V
D
R
L
N
E
G
D
V
L
L
L
E
N
V
R
F
Y
----
P
G
E
----
E
-----------
K
--------------
N
-------
D
P
-------
E
L
A
K
A
-----------
F
----
A
E
L
A
-
D
-
L
Y
V
N
D
A
F
G
A
A
H
R
A
H
A
S
T
E
G
I
A
H
Y
L
-
P
---
A
-
V
---
A
-
G
-
F
L
M
E
K
E
L
E
V
L
G
K
A
L
S
N
P
D
R
P
F
T
A
I
I
G
G
A
K
V
K
D
K
I
G
V
I
D
N
L
L
--
E
--
K
V
D
N
L
I
I
G
G
G
L
A
Y
T
F
V
K
A
L
-
G
H
D
V
G
K
S
L
L
E
E
-------
D
K
I
E
L
A
K
S
F
M
E
K
A
K
E
K
G
V
R
F
Y
----
M
P
V
D
V
V
V
A
D
R
F
A
N
D
A
N
-
T
K
-
V
-
V
P
I
-
D
A
---
I
P
A
D
W
S
A
L
D
I
G
P
K
T
R
E
L
Y
R
D
V
I
R
E
S
K
L
V
V
W
N
G
P
M
G
V
F
E
M
D
A
F
A
H
G
T
K
A
I
A
E
A
L
--
A
--
E
A
L
---
D
--
T
Y
---
S
V
I
G
G
G
D
S
A
A
A
V
E
K
F
G
L
A
D
K
M
D
H
I
S
T
G
G
G
A
S
L
E
F
M
E
G
K
Q
L
P
G
V
V
A
L
E
D
K
2
PsiBlast_PDB
80.87
60%
-63
- C5 -
1VPE
3
PGKT_THEMA
A:
[2-396]
--
K
M
T
I
R
D
V
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
V
K
D
-
G
-
V
V
Q
D
D
T
R
I
R
A
A
L
P
T
I
K
Y
A
L
E
Q
G
A
-
K
-
V
I
L
L
S
H
L
G
R
P
-
K
-
G
-
E
P
----------------
S
----------------
P
E
F
S
-
L
A
P
V
A
K
R
-
L
S
E
L
L
G
K
E
V
K
F
V
P
A
V
V
----
G
-
D
E
V
K
K
A
V
E
E
L
K
E
G
E
V
L
L
L
E
N
T
R
F
H
----
P
G
E
----
T
-----------
K
--------------
N
-------
D
P
-------
E
L
A
K
F
-----------
W
----
A
S
L
A
-
D
-
I
H
V
N
D
A
F
G
T
A
H
R
A
H
A
S
N
V
G
I
A
Q
F
I
-
P
---
S
-
V
---
A
-
G
-
F
L
M
E
K
E
I
K
F
L
S
K
V
T
Y
N
P
E
K
P
Y
V
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
T
N
L
M
--
E
--
K
A
D
R
I
L
I
G
G
A
M
M
F
T
F
L
K
A
L
-
G
K
E
V
G
S
S
R
V
E
E
-------
D
K
I
D
L
A
K
E
L
V
E
K
A
K
E
K
G
V
E
I
V
----
L
P
V
D
A
V
I
A
Q
K
I
E
P
G
V
E
-
K
K
-
V
-
V
R
I
-
D
D
G--
I
P
E
G
W
M
G
L
D
I
G
P
E
T
I
E
L
F
K
Q
K
L
S
D
A
K
T
V
V
W
N
G
P
M
G
V
F
E
I
D
D
F
A
E
G
T
K
Q
V
A
L
A
I
--
A
A
L
T
E
K
---
G
--
A
I
---
T
V
V
G
G
G
D
S
A
A
A
V
N
K
F
G
L
E
D
K
F
S
H
V
S
T
G
G
G
A
S
L
E
F
L
E
G
K
E
L
P
G
I
A
S
M
R
I
K
63
HHSearch
80.63
60%
-63
- C5 -
1VPE
3
PGKT_THEMA
A:
[4-396]
----
T
I
R
D
V
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
V
K
D
-
G
-
V
V
Q
D
D
T
R
I
R
A
A
L
P
T
I
K
Y
A
L
E
Q
G
A
-
K
-
V
I
L
L
S
H
L
G
R
P
-
K
-
G
-
E
P
----------------
S
----------------
P
E
F
S
-
L
A
P
V
A
K
R
-
L
S
E
L
L
G
K
E
V
K
F
V
P
A
V
V
----
G
-
D
E
V
K
K
A
V
E
E
L
K
E
G
E
V
L
L
L
E
N
T
R
F
H
----
P
G
E
----
T
-----------
K
--------------
N
-------
D
P
-------
E
L
A
K
F
-----------
W
----
A
S
L
A
-
D
-
I
H
V
N
D
A
F
G
T
A
H
R
A
H
A
S
N
V
G
I
A
Q
F
I
-
P
---
S
-
V
---
A
-
G
-
F
L
M
E
K
E
I
K
F
L
S
K
V
T
Y
N
P
E
K
P
Y
V
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
T
N
L
M
--
E
--
K
A
D
R
I
L
I
G
G
A
M
M
F
T
F
L
K
A
L
-
G
K
E
V
G
S
S
R
V
E
E
-------
D
K
I
D
L
A
K
E
L
V
E
K
A
K
E
K
G
V
E
I
V
----
L
P
V
D
A
V
I
A
Q
K
I
E
P
G
V
E
-
K
K
-
V
V
R
I
D
-
D
G
---
I
P
E
G
W
M
G
L
D
I
G
P
E
T
I
E
L
F
K
Q
K
L
S
D
A
K
T
V
V
W
N
G
P
M
G
V
F
E
I
D
D
F
A
E
G
T
K
Q
V
A
L
A
I
--
A
--
A
L
T
E
K
-
G
--
A
I
---
T
V
V
G
G
G
D
S
A
A
A
V
N
K
F
G
L
E
D
K
F
S
H
V
S
T
G
G
G
A
S
L
E
F
L
E
G
K
E
L
P
G
I
A
S
M
R
I
K
64
HHSearch
69.74
49%
-9
* C5 *
3Q3V
5
PGK_CAMJE
A:
[9-399]
----
S
I
K
D
I
D
L
A
K
K
K
V
F
I
R
C
D
F
N
V
P
Q
D
D
F
L
-
N
I
T
D
D
R
R
I
R
S
A
I
P
T
I
R
Y
C
L
D
N
G
C
-
S
-
V
I
L
A
S
H
L
G
R
P
-
K
-
E
-
I
-----------------
S
----------------
S
K
Y
S
-
L
E
P
V
A
K
R
-
L
A
R
L
L
D
K
E
I
V
M
A
K
D
V
I
----
G
-
E
D
A
K
T
K
A
M
N
L
K
A
G
E
I
L
L
L
E
N
L
R
F
E
----
K
G
E
----
T
-----------
K
--------------
N
-------
D
E
-------
N
L
A
K
E
-----------
L
----
A
S
M
V
-
Q
-
V
Y
I
N
D
A
F
G
V
C
H
R
A
H
S
S
V
E
A
I
T
K
F
F
-
D
EKH
K
-
G
---
A
-
G
-
F
L
L
Q
K
E
I
D
F
A
S
N
L
I
K
H
P
A
R
P
F
V
A
V
V
G
G
S
K
V
S
G
K
L
Q
A
L
T
N
L
L
--
P
--
K
V
D
K
L
I
I
G
G
G
M
A
F
T
F
L
K
A
L
-
G
Y
D
I
G
N
S
L
L
E
E
-------
E
L
L
E
E
A
N
K
I
L
T
K
G
K
N
L
G
V
K
I
Y
----
L
P
V
D
V
V
A
A
P
A
C
S
Q
D
V
P
-
M
K
-
F
-
V
P
A
-
Q
E
---
I
P
N
G
W
M
G
L
D
I
G
P
A
S
V
R
L
F
K
E
V
I
S
D
A
Q
T
I
W
W
N
G
P
M
G
V
F
E
I
D
K
F
S
K
G
S
I
K
M
S
H
Y
I
--
S
--
E
-
G
---
H
--
A
T
---
S
V
V
G
G
G
D
T
A
D
V
V
A
R
A
G
D
A
D
E
M
T
F
I
S
T
G
G
G
A
S
L
E
L
I
E
G
K
E
L
P
G
V
K
A
L
R
S
-
11
PsiBlast_PDB
68.79
48%
-9
- C5 -
3Q3V
5
PGK_CAMJE
A:
[9-399]
----
S
I
K
D
I
D
L
A
K
K
K
V
F
I
R
C
D
F
N
V
P
Q
D
D
-
F
L
N
I
T
D
D
R
R
I
R
S
A
I
P
T
I
R
Y
C
L
D
N
G
C
-
S
-
V
I
L
A
S
H
L
G
R
P
-
K
---
E
I
----------------
S
----------------
S
K
Y
S
-
L
E
P
V
A
K
R
-
L
A
R
L
L
D
K
E
I
V
M
A
K
D
V
I
----
G
-
E
D
A
K
T
K
A
M
N
L
K
A
G
E
I
L
L
L
E
N
L
R
F
E
----
K
G
E
----
T
-----------
K
--------------
N
-------
D
E
-------
N
L
A
K
E
-----------
L
----
A
S
M
V
-
Q
-
V
Y
I
N
D
A
F
G
V
C
H
R
A
H
S
S
V
E
A
I
T
K
F
F
-
D
---
E
-
K
H
K
G
A
-
G
-
F
L
L
Q
K
E
I
D
F
A
S
N
L
I
K
H
P
A
R
P
F
V
A
V
V
G
G
S
K
V
S
G
K
L
Q
A
L
T
N
L
L
--
P
--
K
V
D
K
L
I
I
G
G
G
M
A
F
T
F
L
K
A
L
-
G
Y
D
I
G
N
S
L
L
E
E
-------
E
L
L
E
E
A
N
K
I
L
T
K
G
K
N
L
G
V
K
I
Y
----
L
P
V
D
V
V
A
A
P
A
C
S
Q
D
V
P
-
M
K
-
F
-
V
P
A
-
Q
E
---
I
P
N
G
W
M
G
L
D
I
G
P
A
S
V
R
L
F
K
E
V
I
S
D
A
Q
T
I
W
W
N
G
P
M
G
V
F
E
I
D
K
F
S
K
G
S
I
K
M
S
H
Y
I
--
S
--
E
G
H
---
A
--
T
----
S
V
V
G
G
G
D
T
A
D
V
V
A
R
A
G
D
A
D
E
M
T
F
I
S
T
G
G
G
A
S
L
E
L
I
E
G
K
E
L
P
G
V
K
A
L
R
S
-
62
HHSearch
68.22
51%
-20
- C5 -
1V6S
3
PGK_THET8
A:
[3-390]
----
T
L
L
D
L
D
P
K
G
K
R
V
L
V
R
V
D
Y
N
V
P
V
Q
D
-
G
-
K
V
Q
D
E
T
R
I
L
E
S
L
P
T
L
R
H
L
L
A
G
G
A
-
S
-
L
V
L
L
S
H
L
G
R
P
-
K
-
G
-
P
-----------------
D
----------------
P
K
Y
S
-
L
A
P
V
G
E
A
-
L
R
A
H
L
P
-
E
A
R
F
A
P
F
P
P
----
G
S
E
E
A
R
R
E
A
E
A
L
R
P
G
E
V
L
L
L
E
N
V
R
F
E
----
P
G
E
----
E
-----------
K
--------------
N
-------
D
P
-------
E
L
S
A
R
-----------
Y
----
A
R
L
G
-
E
-
A
F
V
L
D
A
F
G
S
A
H
R
A
H
A
S
V
V
G
V
A
R
L
L
-
P
---
A
-
Y
---
A
-
G
-
F
L
M
E
K
E
V
R
A
L
S
R
L
L
K
D
P
E
R
P
Y
A
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
E
S
L
L
--
P
--
R
I
D
R
L
L
I
G
G
A
M
A
F
T
F
L
K
A
L
-
G
G
E
V
G
R
S
L
V
E
E
-------
D
R
L
D
L
A
K
D
L
L
G
R
A
E
A
L
G
V
R
V
Y
----
L
P
E
D
V
V
A
A
E
R
I
E
A
G
V
E
-
T
R
-
V
-
F
P
A
-
R
A
---
I
P
V
P
Y
M
G
L
D
I
G
P
K
T
R
E
A
F
A
R
A
L
E
G
A
R
T
V
F
W
N
G
P
M
G
V
F
E
V
P
P
F
D
E
G
T
L
A
V
G
Q
A
I
--
A
--
A
L
E
---
G
--
A
F
---
T
V
V
G
G
G
D
S
V
A
A
V
N
R
L
G
L
K
E
R
F
G
H
V
S
T
G
G
G
A
S
L
E
F
L
E
K
G
T
L
P
G
L
E
V
L
E
G
-
4
PsiBlast_PDB
68.20
50%
-29
- C5 -
1V6S
3
PGK_THET8
A:
[2-389]
---
R
T
L
L
D
L
D
P
K
G
K
R
V
L
V
R
V
D
Y
N
V
P
V
Q
D
-
G
-
K
V
Q
D
E
T
R
I
L
E
S
L
P
T
L
R
H
L
L
A
G
G
A
-
S
-
L
V
L
L
S
H
L
G
R
P
-
K
-
G
-
P
D
---------------------------------
P
K
Y
S
-
L
A
P
V
-----
G
E
A
L
R
A
H
L
P
E
A
R
F
A
P
FPPG
S
-
E
E
A
R
R
E
A
E
A
L
R
P
G
E
V
L
L
L
E
N
V
R
F
E
----
P
G
E
----
E
-----------
K
--------------
N
-------
D
P
-------
E
L
S
A
R
-----------
Y
----
A
R
L
G
-
E
-
A
F
V
L
D
A
F
G
S
A
H
R
A
H
A
S
V
V
G
V
A
R
L
L
-
P
---
A
-
Y
---
A
-
G
-
F
L
M
E
K
E
V
R
A
L
S
R
L
L
K
D
P
E
R
P
Y
A
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
E
S
L
L
--
P
--
R
I
D
R
L
L
I
G
G
A
M
A
F
T
F
L
K
A
L
-
G
G
E
V
G
R
S
L
V
E
E
-------
D
R
L
D
L
A
K
D
L
L
G
R
A
E
A
L
G
V
R
V
Y
----
L
P
E
D
V
V
A
A
E
R
I
E
A
G
V
E
-
T
R
-
V
-
F
P
A
-
R
A
---
I
P
V
P
Y
M
G
L
D
I
G
P
K
T
R
E
A
F
A
R
A
L
E
G
A
R
T
V
F
W
N
G
P
M
G
V
F
E
V
P
P
F
D
E
G
T
L
A
V
G
Q
A
I
--
A
--
A
L
E
---
G
--
A
F
---
T
V
V
G
G
G
D
S
V
A
A
V
N
R
L
G
L
K
E
R
F
G
H
V
S
T
G
G
G
A
S
L
E
F
L
E
K
G
T
L
P
G
L
E
V
L
E
--
21
PsiBlast_CBE
68.16
50%
-29
- C5 -
1V6S
3
PGK_THET8
B:
[2-389]
---
R
T
L
L
D
L
D
P
K
G
K
R
V
L
V
R
V
D
Y
N
V
P
V
Q
D
-
G
-
K
V
Q
D
E
T
R
I
L
E
S
L
P
T
L
R
H
L
L
A
G
G
A
-
S
-
L
V
L
L
S
H
L
G
R
P
-
K
-
G
-
P
D
---------------------------------
P
K
Y
S
-
L
A
P
V
-----
G
E
A
L
R
A
H
L
P
E
A
R
F
A
P
FPPG
S
-
E
E
A
R
R
E
A
E
A
L
R
P
G
E
V
L
L
L
E
N
V
R
F
E
----
P
G
E
----
E
-----------
K
--------------
N
-------
D
P
-------
E
L
S
A
R
-----------
Y
----
A
R
L
G
-
E
-
A
F
V
L
D
A
F
G
S
A
H
R
A
H
A
S
V
V
G
V
A
R
L
L
-
P
---
A
-
Y
---
A
-
G
-
F
L
M
E
K
E
V
R
A
L
S
R
L
L
K
D
P
E
R
P
Y
A
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
E
S
L
L
--
P
--
R
I
D
R
L
L
I
G
G
A
M
A
F
T
F
L
K
A
L
-
G
G
E
V
G
R
S
L
V
E
E
-------
D
R
L
D
L
A
K
D
L
L
G
R
A
E
A
L
G
V
R
V
Y
----
L
P
E
D
V
V
A
A
E
R
I
E
A
G
V
E
-
T
R
-
V
-
F
P
A
-
R
A
---
I
P
V
P
Y
M
G
L
D
I
G
P
K
T
R
E
A
F
A
R
A
L
E
G
A
R
T
V
F
W
N
G
P
M
G
V
F
E
V
P
P
F
D
E
G
T
L
A
V
G
Q
A
I
--
A
--
A
L
E
---
G
--
A
F
---
T
V
V
G
G
G
D
S
V
A
A
V
N
R
L
G
L
K
E
R
F
G
H
V
S
T
G
G
G
A
S
L
E
F
L
E
K
G
T
L
P
G
L
E
V
L
E
--
5
PsiBlast_PDB
67.61
50%
-30
- C5 -
2IE8
-
?
A:
[3-389]
----
T
L
L
D
L
D
P
K
G
K
R
V
L
V
R
V
D
Y
N
V
P
V
Q
D
-
G
-
K
V
Q
D
E
T
R
I
L
E
S
L
P
T
L
R
H
L
L
A
G
G
A
-
S
-
L
V
L
L
S
H
L
G
R
P
-
K
-
G
-
P
D
---------------------------------
P
R
Y
S
-
L
A
P
V
-----
G
E
A
L
R
A
H
L
P
E
A
R
F
A
P
FPPG
S
-
E
E
A
R
R
E
A
E
A
L
R
P
G
E
V
L
L
L
E
N
V
R
F
E
----
P
G
E
----
E
-----------
K
--------------
N
-------
D
P
-------
E
L
S
A
R
-----------
Y
----
A
R
L
G
-
E
-
A
F
V
L
D
A
F
G
S
A
H
R
A
H
A
S
V
V
G
V
A
R
L
L
-
P
---
A
-
Y
---
A
-
G
-
F
L
M
E
K
E
V
R
A
L
S
R
L
L
K
D
P
E
R
P
Y
A
V
V
L
G
G
A
K
V
S
D
K
I
G
V
I
E
S
L
L
--
P
--
R
I
D
R
L
L
I
G
G
A
M
A
F
T
F
L
K
A
L
-
G
G
E
V
G
R
S
L
V
E
E
-------
D
R
L
D
L
A
K
D
L
L
G
R
A
E
A
L
G
V
R
V
Y
----
L
P
E
D
V
V
A
A
E
R
I
E
A
G
V
E
-
T
R
-
V
-
F
P
A
-
R
A
---
I
P
V
P
Y
M
G
L
D
I
G
P
K
T
R
E
A
F
A
R
A
L
E
G
A
R
T
V
F
W
N
G
P
M
G
V
F
E
V
P
P
F
D
E
G
T
L
A
V
G
Q
A
I
--
A
--
A
L
E
---
G
--
A
F
---
T
V
V
G
G
G
D
S
V
A
A
V
N
R
L
G
L
K
E
R
F
G
H
V
S
T
G
G
G
A
S
L
E
F
L
E
K
G
T
L
P
G
L
E
V
L
E
--
13
PsiBlast_PDB
67.04
47%
20
- C5 -
2P9T
1
PGK2_MOUSE
A:
[5-415]
--
K
L
T
L
D
K
V
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
H
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
-
D
-
G
I
P
M
----------------
P
----------------
D
K
Y
S
-
L
E
P
V
A
D
E
-
L
K
S
L
L
N
K
D
V
I
F
L
K
D
C
V
----
G
-
P
E
V
E
Q
A
C
A
N
P
D
N
G
S
I
I
L
L
E
N
L
R
F
H
----
V
E
E
----
E
G
K
G
K
D
SSG
K
K
I
S
--------------
A
-------
D
P
-------
A
K
V
E
A
-----------
F
R
A
S
L
S
K
L
G
-
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
-
P
---
Q
-
K
---
A
S
G
-
F
L
M
K
K
E
L
D
Y
F
S
K
A
L
E
K
P
E
R
P
F
L
A
I
L
G
G
A
K
V
K
D
K
I
Q
L
I
K
N
M
L
--
D
--
K
V
N
F
M
I
I
G
G
G
M
A
Y
T
F
L
K
E
L
K
N
M
Q
I
G
A
S
L
F
D
E
-------
E
G
A
T
I
V
K
E
I
M
E
K
A
E
K
N
G
V
K
I
V
----
F
P
V
D
F
V
T
G
D
K
F
D
E
N
A
K
-
V
G
-
Q
-
A
T
I
E
S
G
---
I
P
S
G
W
M
G
L
D
C
G
P
E
S
I
K
I
N
A
Q
I
V
A
Q
A
K
L
I
V
W
N
G
P
I
G
V
F
E
W
D
A
F
A
K
G
T
K
A
L
M
D
E
V
--
V
--
K
A
T
---
S
N
G
C
V
---
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
G
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
I
L
P
G
V
E
A
L
S
N
-
14
PsiBlast_PDB
66.80
47%
20
- C5 -
2PAA
1
PGK2_MOUSE
A:
[5-415]
--
K
L
T
L
D
K
V
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
H
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
-
D
-
G
I
P
M
----------------
P
----------------
D
K
Y
S
-
L
E
P
V
A
D
E
-
L
K
S
L
L
N
K
D
V
I
F
L
K
D
C
V
----
G
-
P
E
V
E
Q
A
C
A
N
P
D
N
G
S
I
I
L
L
E
N
L
R
F
H
----
V
E
E
----
E
G
K
G
K
D
SSG
K
K
I
S
--------------
A
-------
D
P
-------
A
K
V
E
A
-----------
F
R
A
S
L
S
K
L
G
-
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
-
P
---
Q
-
K
---
A
S
G
-
F
L
M
K
K
E
L
D
Y
F
S
K
A
L
E
K
P
E
R
P
F
L
A
I
L
G
G
A
K
V
K
D
K
I
Q
L
I
K
N
M
L
--
D
--
K
V
N
F
M
I
I
G
G
G
M
A
Y
T
F
L
K
E
L
K
N
M
Q
I
G
A
S
L
F
D
E
-------
E
G
A
T
I
V
K
E
I
M
E
K
A
E
K
N
G
V
K
I
V
----
F
P
V
D
F
V
T
G
D
K
F
D
E
N
A
K
-
V
G
-
Q
-
A
T
I
E
S
G
---
I
P
S
G
W
M
G
L
D
C
G
P
E
S
I
K
I
N
A
Q
I
V
A
Q
A
K
L
I
V
W
N
G
P
I
G
V
F
E
W
D
A
F
A
K
G
T
K
A
L
M
D
E
V
--
V
--
K
A
T
---
S
N
G
C
V
---
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
G
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
I
L
P
G
V
E
A
L
S
N
-
68
HHSearch
66.06
50%
3
- C5 -
3ZLB
8
PGK_STRP2
A:
[1-398]
M
A
K
L
T
V
K
D
V
D
L
K
G
K
K
V
L
V
R
V
D
F
N
V
P
L
K
D
-
G
-
V
I
T
N
D
N
R
I
T
A
A
L
P
T
I
K
Y
I
I
E
Q
G
G
-
R
-
A
I
L
F
S
H
L
G
R
V
-
K
-
E
-
E
S
D---------------
K
----------------
A
G
K
S
-
L
A
P
V
A
A
D
-
L
A
A
K
L
G
Q
D
V
V
F
P
G
V
T
R
----
G
-
A
E
L
E
A
A
I
N
A
L
E
D
G
Q
V
L
L
V
E
N
T
R
Y
E
----
D
V
D
GKKE
S
-----------
K
--------------
N
-------
D
P
-------
E
L
G
K
Y
-----------
W
----
A
S
L
G
D
G
-
I
F
V
N
D
A
F
G
T
A
H
R
A
H
A
S
N
V
G
I
S
A
N
V
-
E
K
--
A
-
V
---
A
-
G
-
F
L
L
E
N
E
I
A
Y
I
Q
E
A
V
E
T
P
E
R
P
F
V
A
I
L
G
G
S
K
V
S
D
K
I
G
V
I
E
N
L
L
--
E
--
K
A
D
K
V
L
I
G
G
G
M
T
Y
T
F
Y
K
A
Q
-
G
I
E
I
G
N
S
L
V
E
E
-------
D
K
L
D
V
A
K
A
L
L
E
K
A
---
N
G
K
L
I
----
L
P
V
D
S
K
E
A
N
A
F
A
G
Y
T
E
-
V
R
-
D
-
T
E
G
-
E
A
---
V
S
E
G
F
L
G
L
D
I
G
P
K
S
I
A
K
F
D
E
A
L
T
G
A
K
T
V
V
W
N
G
P
M
G
V
F
E
N
P
D
F
Q
A
G
T
I
G
V
M
D
A
I
--
V
--
K
Q
P
---
G
--
V
K
---
S
I
I
G
G
G
D
S
A
A
A
A
I
N
L
G
R
A
D
K
F
S
W
I
S
T
G
G
G
A
S
M
E
L
L
E
G
K
V
L
P
G
L
A
A
L
T
E
K
51
PsiBlast_CBE
65.58
46%
22
- C5 -
4O33
2
PGK1_HUMAN
A:
[5-416]
-
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
-
D
-
G
V
P
M
----------------
P
----------------
D
K
Y
S
-
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
----
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
H
----
V
E
E
----
E
G
K
G
K
D
ASG
N
K
V
K
--------------
A
-------
E
P
-------
A
K
I
E
A
-----------
F
R
A
S
L
S
K
L
G
-
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
-
P
---
Q
-
K
---
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
----
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
-
T
G
-
Q
-
A
T
V
A
S
G
---
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
--
T
S
R
---
G
--
C
I
---
T
T
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
69
HHSearch
65.54
48%
17
- C5 -
16PK
2
PGKC_TRYBB
A:
[4-415]
----
S
I
N
E
C
D
L
K
G
K
K
V
L
I
R
V
D
F
N
V
P
V
K
N
-
G
-
K
I
T
N
D
Y
R
I
R
S
A
L
P
T
L
K
K
V
L
T
E
G
G
-
S
-
C
V
L
M
S
H
L
G
R
P
-
K
-
G
-
I
P
MAQ
A
G
K
I
R
S
T
GGVPGF
Q
----------------
Q
K
A
T
-
L
K
P
V
A
K
R
-
L
S
E
L
L
L
R
P
V
T
F
A
P
D
C
L
----
N
---
A
A
D
V
V
S
K
M
S
P
G
D
V
V
L
L
E
N
V
R
F
Y
----
K
E
E
----
G
-----------
S
KK
A
K
----------
D
-------
R
E
-------
A
M
A
K
I
-----------
L
----
A
S
Y
G
-
D
-
V
Y
I
S
D
A
F
G
T
A
H
R
D
S
A
T
M
T
G
I
P
K
I
L
-
G
N
--
G
-
A
---
A
-
G
-
Y
L
M
E
K
E
I
S
Y
F
A
K
V
L
G
N
P
P
R
P
L
V
A
I
V
G
G
A
K
V
S
D
K
I
Q
L
L
D
N
M
L
--
Q
--
R
I
D
Y
L
L
I
G
G
A
M
A
Y
T
F
L
K
A
Q
-
G
Y
S
I
G
K
S
K
C
E
E
-------
S
K
L
E
F
A
R
S
L
L
K
K
A
E
D
R
K
V
Q
V
I
----
L
P
I
D
H
V
C
H
T
E
F
K
A
V
D
S
-
P
L
-
I
-
T
E
D
-
Q
N
---
I
P
E
G
H
M
A
L
D
I
G
P
K
T
I
E
K
Y
V
Q
T
I
G
K
C
K
S
A
I
W
N
G
P
M
G
V
F
E
M
V
P
Y
S
K
G
T
F
A
I
A
K
A
M
--
G
--
R
G
T
H
E
H
G
--
L
M
---
S
I
I
G
G
G
D
S
A
S
A
A
E
L
S
G
E
A
K
R
M
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
T
L
P
G
V
T
V
L
D
D
K
49
PsiBlast_CBE
65.53
46%
18
- C5 -
2XE6
1
PGK1_HUMAN
A:
[5-416]
-
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
-
D
-
G
V
P
M
----------------
P
----------------
D
K
Y
S
-
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
----
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
H
----
V
E
E
----
E
G
K
G
K
D
ASG
N
K
V
K
--------------
A
-------
E
P
-------
A
K
I
E
A
-----------
F
R
A
S
L
S
K
L
G
-
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
-
P
---
Q
-
K
---
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
----
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
-
T
G
-
Q
-
A
T
V
A
S
G
---
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
--
T
S
R
---
G
--
C
I
---
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
8
PsiBlast_PDB
65.52
49%
7
- C5 -
3ZLB
8
PGK_STRP2
A:
[1-398]
M
A
K
L
T
V
K
D
V
D
L
K
G
K
K
V
L
V
R
V
D
F
N
V
P
L
K
D
-
G
-
V
I
T
N
D
N
R
I
T
A
A
L
P
T
I
K
Y
I
I
E
Q
G
G
-
R
-
A
I
L
F
S
H
L
G
R
V
-
K
-
E
-
E
S
----------------
D
----------------
K
A
G
K
S
L
A
P
V
A
A
D
-
L
A
A
K
L
G
Q
D
V
V
F
P
G
V
T
R
----
G
-
A
E
L
E
A
A
I
N
A
L
E
D
G
Q
V
L
L
V
E
N
T
R
Y
E
DVDG
K
K
E
----
S
-----------
K
--------------
N
-------
D
P
-------
E
L
G
K
Y
-----------
W
----
A
S
L
G
-
D
G
I
F
V
N
D
A
F
G
T
A
H
R
A
H
A
S
N
V
G
I
S
A
N
V
E
K
---
A
-
V
---
A
-
G
-
F
L
L
E
N
E
I
A
Y
I
Q
E
A
V
E
T
P
E
R
P
F
V
A
I
L
G
G
S
K
V
S
D
K
I
G
V
I
E
N
L
L
--
E
--
K
A
D
K
V
L
I
G
G
G
M
T
Y
T
F
Y
K
A
Q
-
G
I
E
I
G
N
S
L
V
E
E
-------
D
K
L
D
V
A
K
A
L
L
E
K
A
N
G
K
---
L
I
----
L
P
V
D
S
K
E
A
N
A
F
A
G
Y
T
E
-
V
R
-
D
-
T
E
G
-
E
A
---
V
S
E
G
F
L
G
L
D
I
G
P
K
S
I
A
K
F
D
E
A
L
T
G
A
K
T
V
V
W
N
G
P
M
G
V
F
E
N
P
D
F
Q
A
G
T
I
G
V
M
D
A
I
--
V
--
K
Q
P
---
G
--
V
K
---
S
I
I
G
G
G
D
S
A
A
A
A
I
N
L
G
R
A
D
K
F
S
W
I
S
T
G
G
G
A
S
M
E
L
L
E
G
K
V
L
P
G
L
A
A
L
T
E
K
42
PsiBlast_CBE
65.49
46%
7
- C5 -
3C39
1
PGK1_HUMAN
A:
[8-419]
-
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
-
D
-
G
V
P
M
----------------
P
----------------
D
K
Y
S
-
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
----
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
H
----
V
E
E
----
E
GKGK-------
K
--------------
A
-------
E
P
-------
A
K
I
E
A
-----------
F
R
A
S
L
S
K
L
G
-
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
-
P
---
Q
-
K
---
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
----
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
-
T
G
-
Q
-
A
T
V
A
S
G
---
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
--
T
S
R
---
G
--
C
I
---
T
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
25
PsiBlast_CBE
65.28
45%
20
- C5 -
13PK
5
PGKC_TRYBB
D:
[2-415]
--
K
K
S
I
N
E
C
D
L
K
G
K
K
V
L
I
R
V
D
F
N
V
P
V
K
N
-
G
-
K
I
T
N
D
Y
R
I
R
S
A
L
P
T
L
K
K
V
L
T
E
G
G
-
S
-
C
V
L
M
S
H
L
G
R
P
-
K
-
G
-
I
P
----------------
M
AQAGKIRSTGGVPGFQ
Q
K
A
T
-
L
K
P
V
A
K
R
-
L
S
E
L
L
L
R
P
V
T
F
A
P
D
C
L
----
N
-
A
A
--
D
V
V
S
K
M
S
P
G
D
V
V
L
L
E
N
V
R
F
Y
----
K
E
E
GSKK
A
-----------
K
--------------
D
-------
R
E
-------
A
M
A
K
I
-----------
L
----
A
S
Y
G
-
D
-
V
Y
I
S
D
A
F
G
T
A
H
R
D
S
A
T
M
T
G
I
P
K
I
L
G
N
---
G
-
A
---
A
-
G
-
Y
L
M
E
K
E
I
S
Y
F
A
K
V
L
G
N
P
P
R
P
L
V
A
I
V
G
G
A
K
V
S
D
K
I
Q
L
L
D
N
M
L
--
Q
--
R
I
D
Y
L
L
I
G
G
A
M
A
Y
T
F
L
K
A
Q
-
G
Y
S
I
G
K
S
K
C
E
E
-------
S
K
L
E
F
A
R
S
L
L
K
K
A
E
D
R
K
V
Q
V
I
----
L
P
I
D
H
V
C
H
T
E
F
K
A
V
D
S
-
P
L
-
I
-
T
E
D
-
Q
N
---
I
P
E
G
H
M
A
L
D
I
G
P
K
T
I
E
K
Y
V
Q
T
I
G
K
C
K
S
A
I
W
N
G
P
M
G
V
F
E
M
V
P
Y
S
K
G
T
F
A
I
A
K
A
M
--
G
--
R
G
T
---
H
--
E
H
GLM
S
I
I
G
G
G
D
S
A
S
A
A
E
L
S
G
E
A
K
R
M
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
T
L
P
G
V
T
V
L
D
D
K
19
PsiBlast_PDB
65.28
45%
21
- C5 -
16PK
2
PGKC_TRYBB
A:
[2-415]
--
K
K
S
I
N
E
C
D
L
K
G
K
K
V
L
I
R
V
D
F
N
V
P
V
K
N
-
G
-
K
I
T
N
D
Y
R
I
R
S
A
L
P
T
L
K
K
V
L
T
E
G
G
-
S
-
C
V
L
M
S
H
L
G
R
P
-
K
-
G
-
I
P
----------------
M
AQ
A
G
K
I
R
S
T
GGVPGFQ
Q
K
A
T
-
L
K
P
V
A
K
R
-
L
S
E
L
L
L
R
P
V
T
F
A
P
D
C
L
----
N
-
A
A
--
D
V
V
S
K
M
S
P
G
D
V
V
L
L
E
N
V
R
F
Y
----
K
E
E
GSKK
A
-----------
K
--------------
D
-------
R
E
-------
A
M
A
K
I
-----------
L
----
A
S
Y
G
-
D
-
V
Y
I
S
D
A
F
G
T
A
H
R
D
S
A
T
M
T
G
I
P
K
I
L
G
N
---
G
-
A
---
A
-
G
-
Y
L
M
E
K
E
I
S
Y
F
A
K
V
L
G
N
P
P
R
P
L
V
A
I
V
G
G
A
K
V
S
D
K
I
Q
L
L
D
N
M
L
--
Q
--
R
I
D
Y
L
L
I
G
G
A
M
A
Y
T
F
L
K
A
Q
-
G
Y
S
I
G
K
S
K
C
E
E
-------
S
K
L
E
F
A
R
S
L
L
K
K
A
E
D
R
K
V
Q
V
I
----
L
P
I
D
H
V
C
H
T
E
F
K
A
V
D
S
-
P
L
-
I
-
T
E
D
-
Q
N
---
I
P
E
G
H
M
A
L
D
I
G
P
K
T
I
E
K
Y
V
Q
T
I
G
K
C
K
S
A
I
W
N
G
P
M
G
V
F
E
M
V
P
Y
S
K
G
T
F
A
I
A
K
A
M
--
G
--
R
G
T
---
H
--
E
H
GLM
S
I
I
G
G
G
D
S
A
S
A
A
E
L
S
G
E
A
K
R
M
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
T
L
P
G
V
T
V
L
D
D
K
31
PsiBlast_CBE
65.06
46%
12
- C5 -
2X15
3
PGK1_HUMAN
A:
[4-415]
-
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
-
D
-
G
V
P
M
----------------
P
----------------
D
K
Y
S
-
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
----
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
H
----
V
E
E
----
E
GKGK-------
K
--------------
A
-------
E
P
-------
A
K
I
E
A
-----------
F
R
A
S
L
S
K
L
G
-
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
-
P
---
Q
-
K
---
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
----
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
-
T
G
-
Q
-
A
T
V
A
S
G
---
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
--
T
S
R
---
G
--
C
I
---
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
44
PsiBlast_CBE
65.04
46%
12
- C5 -
4AXX
5
PGK1_HUMAN
A:
[5-416]
-
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
-
D
-
G
V
P
M
----------------
P
----------------
D
K
Y
S
-
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
----
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
H
----
V
E
E
----
E
GKGK----------------------
A
-------
E
P
-------
A
K
I
E
A
-----------
F
R
A
S
L
S
K
L
G
-
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
-
P
---
Q
-
K
---
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
----
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
-
T
G
-
Q
-
A
T
V
A
S
G
---
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
--
T
S
R
---
G
--
C
I
---
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
32
PsiBlast_CBE
65.04
46%
13
- C5 -
2X13
3
PGK1_HUMAN
A:
[4-415]
-
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
-
D
-
G
V
P
M
----------------
P
----------------
D
K
Y
S
-
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
----
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
H
----
V
E
E
----
E
GKGK-------
K
--------------
A
-------
E
P
-------
A
K
I
E
A
-----------
F
R
A
S
L
S
K
L
G
-
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
-
P
---
Q
-
K
---
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
----
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
-
T
G
-
Q
-
A
T
V
A
S
G
---
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
--
T
S
R
---
G
--
C
I
---
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
48
PsiBlast_CBE
64.57
46%
22
- C5 -
2XE7
2
PGK1_HUMAN
A:
[5-416]
-
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
-
D
-
G
V
P
M
----------------
P
----------------
D
K
Y
S
-
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
----
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
H
----
V
E
E
----
E
G
K
G
K
D
ASG
N
K
V
K
--------------
A
-------
E
P
-------
A
K
I
E
A
-----------
F
R
A
S
L
S
K
L
G
-
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
-
P
---
Q
-
K
---
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
----
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
-
T
G
-
Q
-
A
T
V
A
S
G
---
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
--
T
S
R
---
G
--
C
I
---
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
36
PsiBlast_CBE
64.57
46%
24
- C5 -
3C3C
3
PGK1_HUMAN
A:
[8-419]
-
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
-
D
-
G
V
P
M
----------------
P
----------------
D
K
Y
S
-
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
----
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
H
----
V
E
E
----
E
G
K
G
K
D
ASG
N
K
V
K
--------------
A
-------
E
P
-------
A
K
I
E
A
-----------
F
R
A
S
L
S
K
L
G
-
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
-
P
---
Q
-
K
---
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
----
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
-
T
G
-
Q
-
A
T
V
A
S
G
---
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
--
T
S
R
---
G
--
C
I
---
T
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
47
PsiBlast_CBE
64.52
46%
21
- C5 -
2XE8
2
PGK1_HUMAN
A:
[5-416]
-
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
-
D
-
G
V
P
M
----------------
P
----------------
D
K
Y
S
-
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
----
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
H
----
V
E
E
----
E
G
K
G
K
D
ASG
N
K
V
K
--------------
A
-------
E
P
-------
A
K
I
E
A
-----------
F
R
A
S
L
S
K
L
G
-
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
-
P
---
Q
-
K
---
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
----
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
-
T
G
-
Q
-
A
T
V
A
S
G
---
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
--
T
S
R
---
G
--
C
I
---
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
70
HHSearch
64.48
48%
19
- C5 -
2WZB
5
PGK1_HUMAN
A:
[5-415]
--
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
-
D
-
G
-
V
P
M---------------
P
----------------
D
K
Y
S
-
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
----
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
H
----
V
E
E
----
E
-----------
G
KGE
P
A
---------
K
-------
I
E
-------
A
F
R
A
S
-----------
L
----
S
K
L
G
-
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
N
--
L
-
P
Q
--
K
-
A
---
G
-
G
-
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
----
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
T
G
Q
-
A
-
T
V
A
-
S
G
---
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
--
V
--
K
A
T
S
R
-
G
--
C
I
---
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
73
HHSearch
64.43
49%
22
- C5 -
1QPG
2
PGK_YEAST
A:
[7-414]
----
S
V
Q
D
L
D
L
K
D
K
R
V
F
I
R
V
D
F
N
V
P
L
D
G
-
K
-
K
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
-
R
Y
V
V
L
A
S
H
L
G
Q
P
-
N
-
G
-
E
R
----------------
N
----------------
E
K
Y
S
-
L
A
P
V
A
K
E
-
L
Q
S
L
L
G
K
D
V
T
F
L
N
D
C
V
----
G
-
P
E
V
E
A
A
V
K
A
S
A
P
G
S
V
I
L
L
E
N
L
R
Y
H
----
I
E
E
----
E
-----------
G
S
R
K
V
DGQKVKAS
K
E
D
-------
V
Q
-------
K
F
R
H
E
-----------
L
----
S
S
L
A
-
D
-
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
D
--
L
-
P
Q--
R
-
A
---
A
-
G
-
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
L
--
D
--
K
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
K
V
L
E
N
T
E
I
G
D
S
I
F
D
K
-------
A
G
A
E
I
V
P
K
L
M
E
K
A
K
A
K
G
V
E
V
V
----
L
P
V
D
F
I
I
A
D
A
F
S
A
D
A
N
T
K
T
-
V
-
T
D
K
-
E
G
---
I
P
A
G
W
Q
G
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
K
T
I
V
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
L
L
D
E
V
--
V
--
K
S
S
A
A
-
G
--
N
T
---
V
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
46
PsiBlast_CBE
64.37
46%
22
- C5 -
2YBE
5
PGK1_HUMAN
A:
[5-416]
-
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
-
D
-
G
V
P
M
----------------
P
----------------
D
K
Y
S
-
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
----
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
H
----
V
E
E
----
E
GKGKK
V
-----
K
--------------
A
-------
E
P
-------
A
K
I
E
A
-----------
F
R
A
S
L
S
K
L
G
-
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
-
P
---
Q
-
K
---
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
----
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
-
T
G
-
Q
-
A
T
V
A
S
G
---
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
--
T
S
R
---
G
--
C
I
---
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
17
PsiBlast_PDB
64.34
46%
25
- C5 -
1VJD
2
PGK1_PIG
A:
[4-415]
-
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
-
D
-
G
I
P
M
----------------
P
----------------
D
K
Y
S
-
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
----
G
-
P
E
V
E
K
A
C
A
D
P
A
A
G
S
V
I
L
L
E
N
L
R
F
H
----
V
E
E
----
E
G
K
G
K
D
ASG
S
K
V
K
--------------
A
-------
D
P
-------
A
K
I
E
A
-----------
F
R
A
S
L
S
K
L
G
-
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
-
P
---
K
-
K
---
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
S
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
----
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
-
T
G
-
Q
-
A
T
V
A
S
G
---
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
L
M
D
E
V
V
K
A
--
T
S
R
---
G
--
C
I
---
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
40
PsiBlast_CBE
64.16
46%
21
- C5 -
3C3A
1
PGK1_HUMAN
A:
[8-419]
-
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
-
D
-
G
V
P
M
----------------
P
----------------
D
K
Y
S
-
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
----
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
H
----
V
E
E
----
E
G
K
G
K
D
ASGN
K
V
K
--------------
A
-------
E
P
-------
A
K
I
E
A
-----------
F
R
A
S
L
S
K
L
G
-
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
-
P
---
Q
-
K
---
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
----
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
-
T
G
-
Q
-
A
T
V
A
S
G
---
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
--
T
S
R
---
G
--
C
I
---
T
I
I
G
G
---------
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
57
PsiBlast_CBE
64.14
45%
16
- C5 -
1HDI
3
PGK1_PIG
A:
[1-412]
-
N
K
L
T
L
D
K
L
N
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
A
A
-
A
-
Q
I
T
N
N
A
R
I
K
A
A
V
P
S
I
K
F
C
L
D
D
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
-
D
-
G
-
S
P
----------------
M
P---------------
D
K
Y
S
-
L
Q
P
V
A
A
E
-
L
K
S
A
L
G
K
A
V
L
F
L
K
D
C
V
----
G
-
P
A
V
E
K
A
C
A
D
P
A
A
G
S
V
I
L
L
E
N
L
R
F
H
----
V
E
E
----
E
G
K
G
K
D
ASG
N
K
A
A
--------------
G
-------
E
P
-------
A
K
I
K
A
-----------
F
R
A
S
L
S
A
L
G
-
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
-
P
---
K
-
K
---
A
-
G
A
F
L
M
K
K
E
L
N
Y
F
A
A
A
A
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
A
G
K
K
I
V
K
N
L
M
S
K
A
A
A
N
G
V
K
I
T
----
L
P
V
D
F
V
T
A
D
K
F
D
E
Q
A
K
-
I
G
-
Q
-
A
T
V
A
S
G
---
I
P
A
G
W
M
G
L
D
C
G
P
K
S
S
A
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
L
M
D
E
V
V
K
A
--
T
S
R
---
G
--
C
I
---
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
N
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
37
PsiBlast_CBE
64.12
46%
23
- C5 -
3C3B
2
PGK1_HUMAN
B:
[8-419]
-
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
-
D
-
G
V
P
M
----------------
P
----------------
D
K
Y
S
-
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
---------
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
H
----
V
E
E
----
E
G
K
G
K
D
ASG
N
K
V
K
--------------
A
-------
E
P
-------
A
K
I
E
A
-----------
F
R
A
S
L
S
K
L
G
-
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
-
P
---
Q
-
K
---
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
----
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
-
T
G
-
Q
-
A
T
V
A
S
G
---
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
--
T
S
R
---
G
--
C
I
---
T
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
6
PsiBlast_PDB
64.05
48%
15
- C5 -
4FEY
1
PGK_FRATT
A:
[4-392]
M
S
F
L
T
L
K
D
V
D
L
K
D
K
K
V
L
V
R
V
D
F
N
V
P
V
K
D
-
G
-
K
V
T
S
K
V
R
I
E
A
A
I
P
T
I
Q
Y
I
L
D
Q
G
G
-
A
-
V
I
L
M
S
H
L
G
R
P
T
E
-
G
-
E
Y
----------------
D
----------------
S
Q
F
S
-
L
E
P
V
A
K
A
-
L
S
E
I
I
N
K
P
V
K
F
A
K
D
-
W
----
L
-
D
G
V
-----
D
V
K
A
G
E
I
V
M
C
E
N
V
R
F
N
----
S
G
E
----
K
-----------
K
--------------
S
-------
T
D
-------
D
L
S
K
K
-----------
I
----
A
S
L
G
-
D
-
V
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
Y
G
V
A
K
Y
I
-
P
V
--
A
-
C
---
A
-
G
-
I
L
L
T
N
E
I
Q
A
L
E
K
A
L
K
S
P
K
K
P
M
A
A
I
V
G
G
S
K
V
S
T
K
L
S
V
L
N
N
L
L
--
D
--
K
V
E
I
L
I
V
G
G
G
I
A
N
T
F
I
K
A
E
-
G
F
D
V
G
N
S
L
Y
E
Q
-------
D
L
V
A
E
A
T
E
I
L
A
K
A
K
A
L
G
V
N
I
P
----
V
P
V
D
V
R
V
A
K
E
F
S
E
N
A
Q
-
A
I
-
I
-
K
K
V
-
S
D
---
V
V
A
D
E
M
I
L
D
I
G
P
E
S
Q
K
I
I
A
E
L
L
K
S
A
N
T
I
L
W
N
G
P
V
G
V
F
E
F
D
N
F
A
E
G
T
K
A
L
S
L
A
I
--
A
--
Q
S
H
------
A
F
---
S
V
A
G
G
G
D
T
I
A
A
I
E
K
F
G
I
K
D
Q
V
S
Y
I
S
T
A
G
G
A
F
L
E
F
L
E
G
K
K
L
P
A
I
E
I
L
K
E
K
10
PsiBlast_PDB
63.98
46%
6
- C5 -
4NG4
2
PGK_COXBU
A:
[16-400]
----
S
M
S
N
L
N
L
H
N
K
R
V
M
I
R
E
D
L
N
V
P
M
K
N
-
G
-
K
I
T
N
D
E
R
I
V
R
A
L
P
T
I
Q
K
A
I
E
Q
K
A
-
R
-
V
M
I
L
S
H
L
G
R
P
-
E
E
G
-
K
F
----------------
E
----------------
K
E
F
S
-
L
A
P
V
A
-----
R
L
L
S
K
K
-----
P
L
I
----
N
-
D
W
L
K
G
V
A
V
E
--
P
G
Q
A
I
L
C
E
N
V
R
F
N
----
K
G
E
----
N
-----------
E
--------------
N
-------
N
T
-------
E
L
A
K
R
-----------
M
----
A
E
L
C
-
D
-
I
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
A
G
V
A
A
Y
A
-
K
L
--
A
-
C
---
A
-
G
-
P
L
L
I
S
E
V
E
A
L
S
R
A
L
E
N
P
Q
K
P
L
V
A
V
V
G
G
S
K
V
S
T
K
I
H
L
L
E
N
L
L
--
D
--
K
V
D
Q
L
I
V
G
G
G
I
A
N
T
F
L
K
A
Q
-
G
Y
S
I
G
K
S
L
C
E
N
-------
E
W
L
D
A
A
Q
Q
F
W
E
K
A
A
E
K
N
V
S
L
P
----
L
P
V
D
V
I
V
A
D
E
L
S
E
D
A
K
-
A
T
-
V
-
K
N
I
-
D
A
---
V
T
S
N
E
S
I
F
D
V
G
P
N
T
S
A
T
Y
A
K
L
M
A
Q
A
G
T
I
V
W
N
G
P
I
G
V
F
E
I
E
A
F
S
Q
G
T
R
A
L
A
Q
A
V
--
A
--
K
S
----
T
--
A
Y
---
S
I
V
G
G
G
D
T
L
A
A
L
D
K
F
N
L
T
D
Q
M
S
Y
V
S
T
A
G
G
A
F
L
E
F
L
E
G
K
-
L
P
A
I
K
I
L
T
Q
R
50
PsiBlast_CBE
63.97
46%
21
- C5 -
1KF0
3
PGK1_PIG
A:
[4-415]
-
N
K
L
T
L
D
K
L
N
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
D
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
-
D
-
G
-
S
P
----------------
M
P---------------
D
K
Y
S
-
L
Q
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
----
G
-
P
E
V
E
K
A
C
A
D
P
A
A
G
S
V
I
L
L
E
N
L
R
F
H
----
V
E
E
----
E
G
K
G
K
D
ASG
N
K
V
K
--------------
A
-------
E
P
-------
A
K
I
K
T
-----------
F
R
A
S
L
S
K
L
G
-
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
-
P
---
K
-
K
---
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
N
L
M
S
K
A
E
K
N
G
V
K
I
T
----
L
P
V
D
F
V
T
A
D
K
F
D
E
H
A
K
-
T
G
-
Q
-
A
T
V
A
S
G
---
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
L
M
D
E
V
V
K
A
--
T
S
R
---
G
--
C
I
---
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
28
PsiBlast_CBE
63.95
46%
24
- C5 -
4O3F
2
PGK1_MOUSE
A:
[5-416]
-
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
-
D
-
G
V
P
M
----------------
P
----------------
D
K
Y
S
-
L
E
P
V
A
A
E
-
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
----
G
-
P
E
V
E
N
A
C
A
N
P
A
A
G
T
V
I
L
L
E
N
L
R
F
H
----
V
E
E
----
E
G
K
G
K
D
ASG
N
K
V
K
--------------
A
-------
E
P
-------
A
K
I
D
A
-----------
F
R
A
S
L
S
K
L
G
-
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
-
P
---
Q
-
K
---
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
Y
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
----
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
-
T
G
-
Q
-
A
T
V
A
S
G
---
I
P
A
G
W
M
G
L
D
C
G
T
E
S
S
K
K
Y
A
E
A
V
G
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
S
L
M
D
E
V
V
K
A
--
T
S
R
---
G
--
C
I
---
T
I
I
G
G
G
D
T
A
T
--------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
65
HHSearch
63.93
49%
14
- C5 -
4FEY
1
PGK_FRATT
A:
[7-392]
---
L
T
L
K
D
V
D
L
K
D
K
K
V
L
V
R
V
D
F
N
V
P
V
K
D
-
G
-
K
V
T
S
K
V
R
I
E
A
A
I
P
T
I
Q
Y
I
L
D
Q
G
G
-
A
-
V
I
L
M
S
H
L
G
R
P
-
T
-
E
-
G
E
Y---------------
D
----------------
S
Q
F
S
-
L
E
P
V
A
K
A
-
L
S
E
I
I
N
K
P
V
K
F
A
K
D
W
L
----
D
-
G
------
V
D
V
K
A
G
E
I
V
M
C
E
N
V
R
F
N
----
S
G
E
----
K
-----------
K
--------------
S
-------
T
D
-------
D
L
S
K
K
-----------
I
----
A
S
L
G
-
D
-
V
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
Y
G
V
A
K
Y
I
-
P
V
--
A
-
C
---
A
-
G
-
I
L
L
T
N
E
I
Q
A
L
E
K
A
L
K
S
P
K
K
P
M
A
A
I
V
G
G
S
K
V
S
T
K
L
S
V
L
N
N
L
L
--
D
--
K
V
E
I
L
I
V
G
G
G
I
A
N
T
F
I
K
A
E
-
G
F
D
V
G
N
S
L
Y
E
Q
-------
D
L
V
A
E
A
T
E
I
L
A
K
A
K
A
L
G
V
N
I
P
----
V
P
V
D
V
R
V
A
K
E
F
S
E
N
A
Q
-
A
I
-
I
-
K
K
V
-
S
D
---
V
V
A
D
E
M
I
L
D
I
G
P
E
S
Q
K
I
I
A
E
L
L
K
S
A
N
T
I
L
W
N
G
P
V
G
V
F
E
F
D
N
F
A
E
G
T
K
A
L
S
L
A
I
--
A
--
Q
-
S
---
H
--
A
F
---
S
V
A
G
G
G
D
T
I
A
A
I
E
K
F
G
I
K
D
Q
V
S
Y
I
S
T
A
G
G
A
F
L
E
F
L
E
G
K
K
L
P
A
I
E
I
L
K
E
K
41
PsiBlast_CBE
63.93
46%
21
- C5 -
3C39
1
PGK1_HUMAN
B:
[8-419]
-
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
-
D
-
G
V
P
M
----------------
P
----------------
D
K
Y
S
-
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
L
F
L
K
D
-----------
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
H
----
V
E
E
----
E
G
K
G
K
D
ASG
N
K
V
K
--------------
A
-------
E
P
-------
A
K
I
E
A
-----------
F
R
A
S
L
S
K
L
G
-
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
-
P
---
Q
-
K
---
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
----
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
-
T
G
-
Q
-
A
T
V
A
S
G
---
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
--
T
S
R
---
G
--
C
I
---
T
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
33
PsiBlast_CBE
63.93
46%
30
- C5 -
2WZC
5
PGK1_HUMAN
A:
[4-415]
-
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
-
D
-
G
V
P
M
----------------
P
----------------
D
K
Y
S
-
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
----
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
H
----
V
E
E
----
E
GKG-------------------------------
E
P
-------
A
K
I
E
A
-----------
F
R
A
S
L
S
K
L
G
-
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
-
P
---
Q
-
K
---
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
----
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
-
T
G
-
Q
-
A
T
V
A
S
G
---
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
--
T
S
R
---
G
--
C
I
---
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
24
PsiBlast_CBE
63.89
47%
27
- C5 -
2PAA
1
PGK2_MOUSE
B:
[5-415]
--
K
L
T
L
D
K
V
D
L
K
G
K
R
V
I
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
H
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
-
D
-
G
I
P
M
----------------
P
----------------
D
K
Y
S
-
L
E
P
V
A
D
E
-
L
K
S
L
L
N
K
D
V
I
F
L
K
D
C
V
----
G
-
P
E
V
E
Q
A
C
A
N
P
D
N
G
S
I
I
L
L
E
N
L
R
F
H
----
V
E
E
----
E
GKGKDSSGKKI
S
--------------
A
-------
D
P
-------
A
K
V
E
A
-----------
F
RASL
S
K
L
G
-
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
-
P
---
Q
-
K
---
A
S
G
-
F
L
M
K
K
E
L
D
Y
F
S
K
A
L
E
K
P
E
R
P
F
L
A
I
L
G
G
A
K
V
K
D
K
I
Q
L
I
K
N
M
L
--
D
--
K
V
N
F
M
I
I
G
G
G
M
A
Y
T
F
L
K
E
L
K
N
M
Q
I
G
A
S
L
F
D
E
-------
E
G
A
T
I
V
K
E
I
M
E
K
A
E
K
N
G
V
K
I
V
----
F
P
V
D
F
V
T
G
D
K
F
D
E
N
A
K
-
V
G
-
Q
-
A
T
I
E
S
G
---
I
P
S
G
W
M
G
L
D
C
G
P
E
S
I
K
I
N
A
Q
I
V
A
Q
A
K
L
I
V
W
N
G
P
I
G
V
F
E
W
D
A
F
A
K
G
T
K
A
L
M
D
E
V
--
V
--
K
A
T
---
S
NG
C
V
---
T
I
I
G
---------------
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
I
L
P
G
V
E
A
L
S
N
-
45
PsiBlast_CBE
63.84
46%
31
- C5 -
3ZOZ
5
PGK1_HUMAN
A:
[5-416]
-
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
-
D
-
G
V
P
M
----------------
P
----------------
D
K
Y
S
-
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
----
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
H
----
V
E
E
----
E
GKG-------------------------------
E
P
-------
A
K
I
E
A
-----------
F
R
A
S
L
S
K
L
G
-
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
-
P
---
Q
-
K
---
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
----
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
-
T
G
-
Q
-
A
T
V
A
S
G
---
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
--
T
S
R
---
G
--
C
I
---
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
43
PsiBlast_CBE
63.83
46%
27
- C5 -
2ZGV
1
PGK1_HUMAN
A:
[8-419]
-
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
-
D
-
G
V
P
M
----------------
P
----------------
D
K
Y
S
-
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
----
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
H
----
V
E
E
----
E
G
K
G
K
D
ASGN
K
V
K
--------------
A
-------
E
P
-------
A
K
I
E
A
-----------
F
R
A
S
L
S
K
L
G
-
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
-
P
---
Q
-
K
---
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
----
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
-
T
G
-
Q
-
A
T
V
A
S
G
---
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
--
T
S
R
---
G
--
C
I
---
T
I
I
G
G
------------
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
34
PsiBlast_CBE
63.70
46%
27
- C5 -
2WZB
5
PGK1_HUMAN
A:
[4-415]
-
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
-
D
-
G
V
P
M
----------------
P
----------------
D
K
Y
S
-
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
----
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
H
----
V
E
E
----
E
GKG-------------------------------
E
P
-------
A
K
I
E
A
-----------
F
R
A
S
L
S
K
L
G
-
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
-
P
---
Q
-
K
---
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
----
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
-
T
G
-
Q
-
A
T
V
A
S
G
---
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
--
T
S
R
---
G
--
C
I
---
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
23
PsiBlast_CBE
63.58
46%
6
- C5 -
4NG4
2
PGK_COXBU
B:
[16-400]
----
S
M
S
N
L
N
L
H
N
K
R
V
M
I
R
E
D
L
N
V
P
M
K
N
-
G
-
K
I
T
N
D
E
R
I
V
R
A
L
P
T
I
Q
K
A
I
E
Q
K
A
-
R
-
V
M
I
L
S
H
L
G
R
P
-
E
E
G
-
K
F
----------------
E
----------------
K
E
F
S
-
L
A
P
V
A
-----
R
L
L
S
K
K
L
N
-
K
V
P
L
I
----
N
-
D
W
L
K
G
V
A
V
E
--
P
G
Q
A
I
L
C
E
N
V
R
F
N
----
K
G
E
----
N
-----------
E
--------------
N
-------
N
T
-------
E
L
A
K
R
-----------
M
----
A
E
L
C
-
D
-
I
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
A
G
V
A
A
Y
A
-
K
L
--
A
-
C
---
A
-
G
-
P
L
L
I
S
E
V
E
A
L
S
R
A
L
E
N
P
Q
K
P
L
V
A
V
V
G
G
S
K
V
S
T
K
I
H
L
L
E
N
L
L
--
D
--
K
V
D
Q
L
I
V
G
G
G
I
A
N
T
F
L
K
A
Q
-
G
Y
S
I
G
K
S
L
C
E
N
-------
E
W
L
D
A
A
Q
Q
F
W
E
K
A
A
E
K
N
V
S
L
P
----
L
P
V
D
V
I
V
A
D
E
L
S
E
D
A
K
-
A
T
-
V
-
K
N
I
-
D
A
---
V
T
S
N
E
S
I
F
D
V
G
P
N
T
S
A
T
Y
A
K
L
M
A
Q
A
G
T
I
V
W
N
G
P
I
G
V
F
E
I
E
A
F
S
Q
G
T
R
A
L
A
Q
A
V
--
A
--
K
S
----
T
--
A
Y
---
S
I
V
G
G
G
D
T
L
A
A
L
D
K
F
N
L
T
D
Q
M
S
Y
V
S
T
A
G
G
A
F
L
E
F
L
E
G
K
I
L
P
A
I
K
I
L
T
Q
R
22
PsiBlast_CBE
63.37
46%
6
- C5 -
4NG4
2
PGK_COXBU
C:
[16-400]
----
S
M
S
N
L
N
L
H
N
K
R
V
M
I
R
E
D
L
N
V
P
M
K
N
-
G
-
K
I
T
N
D
E
R
I
V
R
A
L
P
T
I
Q
K
A
I
E
Q
K
A
-
R
-
V
M
I
L
S
H
L
G
R
P
-
E
E
G
-
K
F
----------------
E
----------------
K
E
F
S
-
L
A
P
V
A
-----
R
L
L
S
K
K
L
N
--
V
P
L
I
----
N
-
D
W
L
K
G
V
A
V
E
--
P
G
Q
A
I
L
C
E
N
V
R
F
N
----
K
G
E
----
N
-----------
E
--------------
N
-------
N
T
-------
E
L
A
K
R
-----------
M
----
A
E
L
C
-
D
-
I
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
A
G
V
A
A
Y
A
-
K
L
--
A
-
C
---
A
-
G
-
P
L
L
I
S
E
V
E
A
L
S
R
A
L
E
N
P
Q
K
P
L
V
A
V
V
G
G
S
K
V
S
T
K
I
H
L
L
E
N
L
L
--
D
--
K
V
D
Q
L
I
V
G
G
G
I
A
N
T
F
L
K
A
Q
-
G
Y
S
I
G
K
S
L
C
E
N
-------
E
W
L
D
A
A
Q
Q
F
W
E
K
A
A
E
K
N
V
S
L
P
----
L
P
V
D
V
I
V
A
D
E
L
S
E
D
A
K
-
A
T
-
V
-
K
N
I
-
D
A
---
V
T
S
N
E
S
I
F
D
V
G
P
N
T
S
A
T
Y
A
K
L
M
A
Q
A
G
T
I
V
W
N
G
P
I
G
V
F
E
I
E
A
F
S
Q
G
T
R
A
L
A
Q
A
V
--
A
--
K
S
----
T
--
A
Y
---
S
I
V
G
G
G
D
T
L
A
A
L
D
K
F
N
L
T
D
Q
M
S
Y
V
S
T
A
G
G
A
F
L
E
F
L
E
G
--
L
P
A
I
K
I
L
T
Q
R
66
HHSearch
63.27
46%
8
- C5 -
4NG4
2
PGK_COXBU
A:
[16-400]
----
S
M
S
N
L
N
L
H
N
K
R
V
M
I
R
E
D
L
N
V
P
M
K
N
-
G
-
K
I
T
N
D
E
R
I
V
R
A
L
P
T
I
Q
K
A
I
E
Q
K
A
-
R
-
V
M
I
L
S
H
L
G
R
P
-
E
-
E
-
G
K
F---------------
E
----------------
K
E
F
S
-
L
A
P
V
A
R
L
-
L
S
K
K
-----
P
L
I
N
D
W
L
----
K
-
G
V
------
A
V
E
P
G
Q
A
I
L
C
E
N
V
R
F
N
----
K
G
E
----
N
-----------
E
--------------
N
-------
N
T
-------
E
L
A
K
R
-----------
M
----
A
E
L
C
-
D
-
I
F
V
M
D
A
F
A
T
A
H
R
A
Q
A
S
T
A
G
V
A
A
Y
A
-
K
L
--
A
-
C
---
A
-
G
-
P
L
L
I
S
E
V
E
A
L
S
R
A
L
E
N
P
Q
K
P
L
V
A
V
V
G
G
S
K
V
S
T
K
I
H
L
L
E
N
L
L
--
D
--
K
V
D
Q
L
I
V
G
G
G
I
A
N
T
F
L
K
A
Q
-
G
Y
S
I
G
K
S
L
C
E
N
-------
E
W
L
D
A
A
Q
Q
F
W
E
K
A
A
E
K
N
V
S
L
P
----
L
P
V
D
V
I
V
A
D
E
L
S
E
D
A
K
-
A
T
-
V
-
K
N
I
-
D
A
---
V
T
S
N
E
S
I
F
D
V
G
P
N
T
S
A
T
Y
A
K
L
M
A
Q
A
G
T
I
V
W
N
G
P
I
G
V
F
E
I
E
A
F
S
Q
G
T
R
A
L
A
Q
A
V
--
A
--
K
-
S
---
T
--
A
Y
---
S
I
V
G
G
G
D
T
L
A
A
L
D
K
F
N
L
T
D
Q
M
S
Y
V
S
T
A
G
G
A
F
L
E
F
L
E
G
K
-
L
P
A
I
K
I
L
T
Q
R
30
PsiBlast_CBE
63.21
46%
26
- C5 -
2Y3I
5
PGK1_HUMAN
A:
[5-416]
-
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
-
D
-
G
V
P
M
----------------
P
----------------
D
K
Y
S
-
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
----
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
H
----
V
E
E
----
E
G
K
G
K
D
ASGN
K
V
K
--------------
A
-------
E
P
-------
A
K
I
E
A
-----------
F
R
A
S
L
S
K
L
G
-
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
-
P
---
Q
-
K
---
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
----
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
-
T
G
-
Q
-
A
T
V
A
S
G
---
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
--
T
S
R
---
G
--
C
I
---
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
9
PsiBlast_PDB
63.18
47%
25
- C5 -
1QPG
2
PGK_YEAST
A:
[4-414]
-
S
K
L
S
V
Q
D
L
D
L
K
D
K
R
V
F
I
R
V
D
F
N
V
P
L
D
G
-
K
-
K
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
-
R
Y
V
V
L
A
S
H
L
G
Q
P
-
N
-
G
-
E
R
----------------
N
----------------
E
K
Y
S
-
L
A
P
V
A
K
E
-
L
Q
S
L
L
G
K
D
V
T
F
L
N
D
C
V
----
G
-
P
E
V
E
A
A
V
K
A
S
A
P
G
S
V
I
L
L
E
N
L
R
Y
H
IEE-
E
G
S
----
R
-----------
K
--------------
V
-------
D
G
-------
Q
K
V
K
A
S
K
E
D
V
Q
K
F
R
H
E
L
----
S
S
L
A
-
D
-
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
--
D
L
-
P
---
Q
R
A
---
A
-
G
-
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
L
--
D
--
K
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
K
V
L
E
N
T
E
I
G
D
S
I
F
D
K
-------
A
G
A
E
I
V
P
K
L
M
E
K
A
K
A
K
G
V
E
V
V
----
L
P
V
D
F
I
I
A
D
A
F
S
A
D
A
N
-
T
K
-
T
-
V
T
D
-
K
E
G--
I
P
A
G
W
Q
G
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
K
T
I
V
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
L
L
D
E
V
V
K
S
--
S
A
A
---
G
--
N
T
---
V
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
35
PsiBlast_CBE
63.13
46%
26
- C5 -
3C3C
1
PGK1_HUMAN
B:
[8-419]
-
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
-
D
-
G
V
P
M
----------------
P
----------------
D
K
Y
S
-
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
---------
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
H
----
V
E
E
----
E
G
K
G
K
D
AS
G
N
K
V
K
--------------
A
-------
E
P
-------
A
K
I
E
A
-----------
F
R
A
S
L
S
K
L
G
-
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
-
P
---
Q
-
K
---
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
----
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
-
T
G
-
Q
-
A
T
V
A
S
G
---
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
--
T
S
R
---
G
--
C
I
---
T
I
I
G
G
-------------
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
54
PsiBlast_CBE
63.12
46%
29
- C5 -
2X14
3
PGK1_HUMAN
A:
[4-415]
-
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
-
D
-
G
V
P
M
----------------
P
----------------
D
K
Y
S
-
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
----
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
H
----
V
E
E
----
E
GKG-------------------------------
E
P
-------
A
K
I
E
A
-----------
F
R
A
S
L
S
K
L
G
-
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
-
P
---
Q
-
K
---
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
A
I
Q
L
I
N
N
M
L
--
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
----
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
-
T
G
-
Q
-
A
T
V
A
S
G
---
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
--
T
S
R
---
G
--
C
I
---
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
55
PsiBlast_CBE
62.87
46%
29
- C5 -
2WZD
5
PGK1_HUMAN
A:
[5-416]
-
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
-
D
-
G
V
P
M
----------------
P
----------------
D
K
Y
S
-
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
----
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
H
----
V
E
E
----
E
GKG-------------------------------
E
P
-------
A
K
I
E
A
-----------
F
R
A
S
L
S
K
L
G
-
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
-
P
---
Q
-
K
---
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
A
I
Q
L
I
N
N
M
L
--
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
----
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
-
T
G
-
Q
-
A
T
V
A
S
G
---
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
--
T
S
R
---
G
--
C
I
---
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
16
PsiBlast_PDB
62.87
46%
26
- C5 -
1VJC
1
PGK1_PIG
A:
[4-415]
-
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
I
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
-
D
-
G
I
P
M
----------------
P
----------------
D
K
Y
S
-
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
----
G
-
P
E
V
E
K
A
C
A
D
P
A
A
G
S
V
I
L
L
E
N
L
R
F
H
----
V
E
E
----
E
G
K
G
K
D
ASG
S
K
V
K
--------------
A
-------
D
P
-------
A
K
I
E
A
-----------
F
R
A
S
L
S
K
L
G
-
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
-
P
---
K
-
K
---
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
S
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
----
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
-
T
G
-
Q
-
A
T
V
A
S
G
---
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
S
E
A
V
A
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
Q
G
T
K
A
L
M
D
E
V
V
K
A
--
T
S
R
---
G
--
C
I
---
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
39
PsiBlast_CBE
62.63
46%
22
- C5 -
3C3A
3
PGK1_HUMAN
B:
[8-419]
-
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
-
D
-
G
V
P
M
----------------
P
----------------
D
K
Y
S
-
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
----------
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
H
----
V
E
E
----
E
G
K
G
K
D
AS
G
N
K
V
K
--------------
A
-------
E
P
-------
A
K
I
E
A
-----------
F
R
A
S
L
S
K
L
G
-
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
-
P
---
Q
-
K
---
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
----
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
-
T
G
-
Q
-
A
T
V
A
S
G
---
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
V
K
A
--
T
S
R
---
G
--
C
I
---
T
I
I
G
G
------------
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
29
PsiBlast_CBE
62.11
46%
27
- C5 -
2Y3I
5
PGK1_HUMAN
D:
[5-416]
-
N
K
L
T
L
D
K
L
D
V
K
G
K
R
V
V
M
R
V
D
F
N
V
P
M
K
N
-
N
-
Q
I
T
N
N
Q
R
I
K
A
A
V
P
S
I
K
F
C
L
D
N
G
A
-
K
S
V
V
L
M
S
H
L
G
R
P
-
D
-
G
V
P
M
----------------
P
----------------
D
K
Y
S
-
L
E
P
V
A
V
E
-
L
K
S
L
L
G
K
D
V
L
F
L
K
D
C
V
----
G
-
P
E
V
E
K
A
C
A
N
P
A
A
G
S
V
I
L
L
E
N
L
R
F
H
----
V
E
E
----
E
GKGKDASGNKV
K
--------------
A
-------
E
P
-------
A
K
I
E
A
-----------
F
RASL
S
K
L
G
-
D
-
V
Y
V
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
V
--
N
L
-
P
---
Q
-
K
---
A
-
G
G
F
L
M
K
K
E
L
N
Y
F
A
K
A
L
E
S
P
E
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
N
N
M
L
--
D
--
K
V
N
E
M
I
I
G
G
G
M
A
F
T
F
L
K
V
L
N
N
M
E
I
G
T
S
L
F
D
E
-------
E
G
A
K
I
V
K
D
L
M
S
K
A
E
K
N
G
V
K
I
T
----
L
P
V
D
F
V
T
A
D
K
F
D
E
N
A
K
-
T
G
-
Q
-
A
T
V
A
S
G
---
I
P
A
G
W
M
G
L
D
C
G
P
E
S
S
K
K
Y
A
E
A
V
T
R
A
K
Q
I
V
W
N
G
P
V
G
V
F
E
W
E
A
F
A
R
G
T
K
A
L
M
D
E
V
VK
A
--
T
S
R
---
G
--
C
I
---
T
I
I
G
G
G
D
T
A
T
C
C
A
K
W
N
T
E
D
K
V
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
V
L
P
G
V
D
A
L
S
N
-
75
HHSearch
61.41
38%
-35
- C5 -
2CUN
5
PGK_PYRHO
A:
[3-401]
----
R
L
E
D
F
N
F
H
N
K
T
V
F
L
R
V
D
L
N
S
P
M
K
D
-
G
-
K
I
I
S
D
A
R
F
K
A
V
L
P
T
I
R
Y
L
I
E
S
G
A
-
K
-
V
V
I
G
T
H
Q
G
K
P
-
Y
-
S
-
E
----------------------------------
D
Y
T
T
-
T
E
E
H
A
R
V
-
L
S
E
L
L
D
Q
H
V
E
Y
I
E
D
I
F
----
G
-
R
Y
A
R
E
K
I
K
E
L
K
S
G
E
V
A
I
L
E
N
L
R
F
S
----
A
E
E
----
V
-----------
K
--------------
N
K
P
I
E
E
C
E
K
T
-------
F
L
V
K
K
-----------
L
----
S
K
V
I
-
D
-
Y
V
V
N
D
A
F
A
T
A
H
R
S
Q
P
S
L
V
G
F
A
R
I
K
-
P
---
M
-
I
---
M
-
G
-
F
L
M
E
K
E
I
E
A
L
M
R
A
Y
Y
S
K
D
S
P
K
I
Y
V
L
G
G
A
K
V
E
D
S
L
K
V
V
E
N
V
L
--
R
R
E
R
A
D
L
V
L
T
G
G
L
V
A
N
V
F
T
L
A
K
-
G
F
D
L
G
R
K
N
V
E
F
M
K
K
K
GLL
D
Y
V
K
H
A
E
E
I
L
D
E
---
F
Y
P
Y
I
R
----
T
P
V
D
F
A
V
D
Y
K
G
E
R
V
E
I
-
D
L
-
L
-
S
E
N
-
R
G
---
L
L
H
Q
Y
Q
I
M
D
I
G
K
R
T
A
E
K
Y
R
E
I
L
M
K
A
R
I
I
V
A
N
G
P
M
G
V
F
E
R
E
E
F
A
I
G
T
V
E
V
F
K
A
I
--
A
--
D
-
S
---
P
--
A
F
---
S
V
L
G
G
G
H
S
I
A
S
I
Q
K
Y
G
I
-
T
G
I
T
H
I
S
T
G
G
G
A
M
L
S
F
F
A
G
E
E
L
P
V
L
R
A
L
Q
I
S
60
PsiBlast_CBE
60.72
38%
4
- C5 -
2CUN
5
PGK_PYRHO
A:
[4-399]
-----
L
E
D
F
N
F
H
N
K
T
V
F
L
R
V
D
L
N
S
P
M
K
D
-
G
-
K
I
I
S
D
A
R
F
K
A
V
L
P
T
I
R
Y
L
I
E
S
G
A
-
K
-
V
V
I
G
T
H
Q
G
K
P
-
Y
-
S
-
E
-----------------------------------
D
Y
T
-
T
T
E
E
H
A
R
V
L
S
E
L
L
D
Q
H
V
E
Y
I
E
D
I
F
----
G
-
R
Y
A
R
E
K
I
K
E
L
K
S
G
E
V
A
I
L
E
N
L
R
F
S
----
A
E
E
----
V
-----------
K
--------------
N
-------
K
P
I
E
E
C
E
K
T
F
L
V
K
K
-----------
L
----
S
K
V
I
-
D
-
Y
V
V
N
D
A
F
A
T
A
H
R
S
Q
P
S
L
V
G
F
A
R
I
K
-
P
---
M
-
I
---
M
-
G
-
F
L
M
E
K
E
I
E
A
L
M
R
A
Y
Y
S
K
D
S
P
K
I
Y
V
L
G
G
A
K
V
E
D
S
L
K
V
V
E
N
V
L
R
R
E
--
R
A
D
L
V
L
T
G
G
L
V
A
N
V
F
T
L
A
K
-
G
F
D
L
G
R
K
N
V
E
F
-------
M
K
K
K
G
L
L
D
Y
V
K
H
A
E
E
I
L
D
E
F
Y
PY
I
R
T
P
V
D
F
A
V
--
D
Y
K
G
E
-
R
-
V
E
-
I
-
D
L
L
-
S
E
NR
G
L
L
H
Q
Y
Q
I
M
D
I
G
K
R
T
A
E
K
Y
R
E
I
L
M
K
A
R
I
I
V
A
N
G
P
M
G
V
F
E
R
E
E
F
A
I
G
T
V
E
V
F
K
A
I
--
A
--
D
S
----
P
--
A
F
---
S
V
L
G
G
G
H
S
I
A
S
I
Q
K
Y
G
I
T
G
-
I
T
H
I
S
T
G
G
G
A
M
L
S
F
F
A
G
E
E
L
P
V
L
R
A
L
Q
--
59
PsiBlast_CBE
60.00
38%
7
- C5 -
2CUN
5
PGK_PYRHO
B:
[4-399]
-----
L
E
D
F
N
F
H
N
K
T
V
F
L
R
V
D
L
N
S
P
M
K
D
-
G
-
K
I
I
S
D
A
R
F
K
A
V
L
P
T
I
R
Y
L
I
E
S
G
A
-
K
-
V
V
I
G
T
H
Q
G
K
P
-
Y
-
S
-
E
-----------------------------------
D
Y
T
-
T
T
E
E
H
A
R
V
L
S
E
L
L
D
Q
H
V
E
Y
I
E
D
I
F
----
G
-
R
Y
A
R
E
K
I
K
E
L
K
S
G
E
V
A
I
L
E
N
L
R
F
S
----
A
E
E
----
V
-----------
K
--------------
N
-------
K
P
IEECEKT
F
L
V
K
K
-----------
L
----
S
K
V
I
-
D
-
Y
V
V
N
D
A
F
A
T
A
H
R
S
Q
P
S
L
V
G
F
A
R
I
K
-
P
---
M
-
I
---
M
-
G
-
F
L
M
E
K
E
I
E
A
L
M
R
A
Y
Y
S
K
D
S
P
K
I
Y
V
L
G
G
A
K
V
E
D
S
L
K
V
V
E
N
V
L
RR
E
--
R
A
D
L
V
L
T
G
G
L
V
A
N
V
F
T
L
A
K
-
G
F
D
L
G
R
K
N
V
E
F
-------
M
K
K
K
G
L
L
D
Y
V
K
H
A
E
E
I
L
D
E
F
Y
PYIR
T
P
V
D
F
A
V
--
D
Y
K
G
E
-
R
-
V
E
-
I
-
D
L
L
-
S
E
NRG
L
L
H
Q
Y
Q
I
M
D
I
G
K
R
T
A
E
K
Y
R
E
I
L
M
K
A
R
I
I
V
A
N
G
P
M
G
V
F
E
R
E
E
F
A
I
G
T
V
E
V
F
K
A
I
--
A
--
D
S
----
P
--
A
F
---
S
V
L
G
G
G
H
S
I
A
S
I
Q
K
Y
G
I
T
G
-
I
T
H
I
S
T
G
G
G
A
M
L
S
F
F
A
G
E
E
L
P
V
L
R
A
L
Q
--
76
HHSearch
51.51
48%
39
- C5 -
1FW8
5
PGK_YEAST
A:
[1-343]
-----------------------------------------------------------------------------------------------------------
S
K
Y
S
-
L
A
P
V
A
K
E
-
L
Q
S
L
L
G
K
D
V
T
F
L
N
D
C
V
----
G
-
P
E
V
E
A
A
V
K
A
S
A
P
G
S
V
I
L
L
E
N
L
R
Y
H
----
I
E
E
----
E
-----------
G
S
R
K
V
DG
Q
K
V
K
A
S
K
E
D
-------
V
Q
-------
K
F
R
H
E
-----------
L
----
S
S
L
A
-
D
-
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
D
--
L
-
P
Q--
R
-
A
---
A
-
G
-
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
L
--
D
--
K
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
K
V
L
E
N
T
E
I
G
D
S
I
F
D
K
-------
A
G
A
E
I
V
P
K
L
M
E
K
A
K
A
K
G
V
E
V
V
----
L
P
V
D
F
I
I
A
D
A
F
S
A
D
A
N
-
T
K
T
V
-
T
D
K
-
E
G
---
I
P
A
G
W
Q
G
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
K
T
I
V
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
L
L
D
E
V
--
V
--
K
S
S
A
A
-
G
--
N
T
---
V
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
58
PsiBlast_CBE
50.02
47%
40
- C5 -
1FW8
4
PGK_YEAST
A:
[5-343]
----------------------------------------------------------------------------------------------------------------
L
A
P
V
A
K
E
-
L
Q
S
L
L
G
K
D
V
T
F
L
N
D
C
V
----
G
-
P
E
V
E
A
A
V
K
A
S
A
P
G
S
V
I
L
L
E
N
L
R
Y
H
IEE-
E
G
S
----
R
-----------
K
--------------
V
-------
D
G
-------
Q
K
V
K
A
S
K
E
D
V
Q
K
F
R
H
E
L
----
S
S
L
A
-
D
-
V
Y
I
N
D
A
F
G
T
A
H
R
A
H
S
S
M
V
G
F
--
D
L
-
P
---
Q
R
A
---
A
-
G
-
F
L
L
E
K
E
L
K
Y
F
G
K
A
L
E
N
P
T
R
P
F
L
A
I
L
G
G
A
K
V
A
D
K
I
Q
L
I
D
N
L
L
--
D
--
K
V
D
S
I
I
I
G
G
G
M
A
F
T
F
K
K
V
L
E
N
T
E
I
G
D
S
I
F
D
K
-------
A
G
A
E
I
V
P
K
L
M
E
K
A
K
A
K
G
V
E
V
V
----
L
P
V
D
F
I
I
A
D
A
F
S
A
D
A
N
-
T
K
-
T
-
V
T
D
-
K
E
G--
I
P
A
G
W
Q
G
L
D
N
G
P
E
S
R
K
L
F
A
A
T
V
A
K
A
K
T
I
V
W
N
G
P
P
G
V
F
E
F
E
K
F
A
A
G
T
K
A
L
L
D
E
V
V
K
S
--
S
A
A
---
G
--
N
T
---
V
I
I
G
G
G
D
T
A
T
V
A
K
K
Y
G
V
T
D
K
I
S
H
V
S
T
G
G
G
A
S
L
E
L
L
E
G
K
E
L
P
G
V
A
F
L
S
E
K
77
HHSearch
39.06
55%
-186
- C5 -
1FW8
2
PGK_YEAST
A:
[351-413]
----
S
V
Q
D
L
D
L
K
D
K
R
V
F
I
R
V
D
F
N
V
P
L
D
G
-
K
-
K
I
T
S
N
Q
R
I
V
A
A
L
P
T
I
K
Y
V
L
E
H
H
P
R
Y
-
V
V
L
A
S
H
L
G
R
P
-
N
-
G
-
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------