@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu33960: (2016-07-27 )
MKNTPTQLEPNVPVTRSHSMGFVILISCAAGLGGLLYGYDTAVISGAIGFLKDLYSLSPFMEGLVISSIMIGGVVGVGISGFLSDRFGRRKILMTAALLFAISAIVSALSQDVSTLIIARIIGGLGIGMGSSLSVTYITEAAPPAIRGSLSSLYQLFTILGISATYFINLAVQRSGTYEWGVHTGWRWMLAYGMVPSVIFFLVLLVVPESPRWLAKAGKTNEALKILTRINGETVAKEELKNIENSLKIEQMGSLSQLFKPGLRKALVIGILLALFNQVIGMNAITYYGPEIFKMMGFGQNAGFVTTCIVGVVEVIFTVIAVLLIDKVGRKKLMSIGSAFMAIFMILIGTSFYFELTSGIMMIVLILGFVAAFCVSVGPITWIMISEIFPNHLRARAAGIATIFLWGANWAIGQFVPMMIDSFGLAYTFWIFAVINILCFLFVVTICPETKNKSLEEIEKLWIK
Atome Classification :
(20 SA)
.........10........20.......--.30........40........50....--------.--------------.--------------..60.--------------.--------------......70----------.........80........90........100....---..------------------.------------------110-.........120.......130.......140.......150.......160.......170.......-180.......190.......200.......210...-..-..-220-...-....230-.---.....--.240..---...---..-250.....--...260-........270.......280.......290.......300.......310.......320.......330.....-..340.....--..350..-.---.-.--..-360......---...370.......380.......390.......400.......410.---.....------.------420.......430.......440.......450.......460..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKNTPTQLEPNVPVTRSHSM
G
F
V
I
L
I
S
C
--
A
AGL
G
G
L
L
Y
GY
D
T
A
V
I
S
G
A
I
G
F
L
K
D
L
Y
--------
S
--------------
L
--------------
S
P
F
M
E
--------------
G
--------------
L
V
I
S
S
I
M
-----------IG
G
V
V
G
V
G
I
S
G
F
L
S
DRFGR
R
K
I
L
M
T
A
A
L
L
F
A
I
S
A
I
V
---
S
A
------------------
L
------------------
S
---
Q
D
V
S
T
L
I
I
A
R
I
I
G
G
LGIGMGS
S
L
S
V
T
Y
I
TEAA
P
P
A
I
R
G
S
L
S
S
L
Y
Q
L
F
T
I
LGI
S
A
T
Y
F
I
N
L
A
V
Q
RSG
T
Y
E-WGVHT
G
W
R
W
M
L
A
YG
M
V
P
S
V
I
F
F
L
V
L
L
VVPES
P
R
W
L
A
-KA-GK-T
N
E
-
A
L
K
-
I
L
T
RING-E---
T
V
A
K
E
--
E
L
K
N
I
E
---
N
S
L
---
K
I
-
E
Q
-
M
G
S
L
S
--
Q
L
F
K
-
P
-
G
L
R
K
A
L
V
I
G
I
L
L
A
L
F
N
Q
V
IGMN
A
I
TYY
G
P
E
I
F
K
M
MGFGQNA
G
F
V
T
T
C
I
V
G
V
V
E
V
I
F
T
V
I
A
V
L
L
I
D
KV
G
R
K
K
L
M
S
I
G
-
S
A
F
M
A
I
F
M
I
L
--IGT
S
F
Y
F
-
E
---
L
-T--S
G
-
I
--
M
M
I
V
L
I
---
L
G
F
V
A
A
F
C
VSVG
P
I
T
W
I
M
I
S
E
I
F
P
N
H
L
R
A
R
AAG
I
A
T
I
F
L
WGANW
A
I
G
---
Q
F
V
P
M
------
M
------
I
D
SF
G
L
A
Y
T
F
W
I
F
A
V
I
N
I
L
C
F
L
F
V
V
TICPETKNK
S
L
E
E
I
E
K
L
WIK
46
Fugue
85.89
41%
-122
- C2 -
4GC0
5
XYLE_ECOLI
A:
[5-479]
-----------------
Y
N
S
S
Y
I
F
S
I
T
L
--
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
VAPQNLS
E
S
--------------
A
--------------
A
N
S
L
L
--------------
G
--------------
F
C
V
A
S
A
L
-----------
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
---
S
A
WPELGFTSINPDNTVPVY
L
------------------
A
---
G
Y
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
S
G
D
A
S
-
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
-
S
R
-
G
K
-
Q
E
Q
-
A
E
G
-
I
L
R
K
I
M
G
-
N
---
T
L
A
T
Q
--
A
V
Q
E
I
K
---
H
S
L
---
D
H
-
G
R
-
K
T
G
G
R
--
L
L
M
F
-
G
---
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
-
A
L
G
M
A
I
G
M
F
S
--
L
G
T
A
F
Y
T
-
Q
-----
A
--
P
G
-
I
--
V
A
L
L
S
M
---
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
---
W
T
F
P
M
M
D
K
N
S
W
L
------
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
E
-
4
PsiBlast_PDB
85.24
38%
-117
- C2 -
4GC0
5
XYLE_ECOLI
A:
[5-478]
-----------------
Y
N
S
S
Y
I
F
S
I
T
L
--
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
VAPQNLS
E
S
--------------
A
--------------
A
N
S
L
L
--------------
G
--------------
F
C
V
A
S
A
L
-----------
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
---
S
A
WPELGFTSINPDNTVPVY
L
------------------
A
---
G
Y
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
S
G
D
A
S
-
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
-
S
R
-
G
K
-
Q
E
Q
-
A
E
G
-
I
L
R
K
I
M
G
-
N
---
T
L
A
T
Q
--
A
V
Q
E
I
K
---
H
S
L
---
D
H
G
R
K
-
T
G
G
R
L
--
L
M
F
G
-
V
-
G
V
---
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
-
A
L
G
M
A
I
G
M
F
S
--
L
G
T
A
F
Y
T
-
Q
-----
A
--
P
G
-
I
--
V
A
L
L
S
M
---
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
---
W
T
F
P
M
------
M
D
K
N
S
W
L
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
--
3
PsiBlast_PDB
84.94
38%
-115
- C2 -
4GBZ
5
XYLE_ECOLI
A:
[5-478]
-----------------
Y
N
S
S
Y
I
F
S
I
T
L
--
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
VAPQNLS
E
S
--------------
A
--------------
A
N
S
L
L
--------------
G
--------------
F
C
V
A
S
A
L
-----------
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
---
S
A
W
PELGFTSINPDNTVPVY
L
------------------
A
---
G
Y
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
S
G
D
A
S
-
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
-
S
R
-
G
K
-
Q
E
Q
-
A
E
G
-
I
L
R
K
I
M
G
-
N
---
T
L
A
T
Q
--
A
V
Q
E
I
K
---
H
S
L
---
D
H
G
R
K
-
T
G
G
R
L
--
L
M
F
G
-
V
-
G
V
---
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
-
A
L
G
M
A
I
G
M
F
S
--
L
G
T
A
F
Y
T
-
Q
-----
A
--
P
G
-
I
--
V
A
L
L
S
M
---
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
---
W
T
F
P
M
------
M
D
K
N
S
W
L
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
--
2
PsiBlast_PDB
84.89
38%
-119
- C2 -
4GBY
5
XYLE_ECOLI
A:
[5-478]
-----------------
Y
N
S
S
Y
I
F
S
I
T
L
--
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
VAPQNLS
E
S
--------------
A
--------------
A
N
S
L
L
--------------
G
--------------
F
C
V
A
S
A
L
-----------
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
---
S
A
WPELGFTSINPDNTVPVY
L
------------------
A
---
G
Y
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
S
G
D
A
S
-
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
-
S
R
-
G
K
-
Q
E
Q
-
A
E
G
-
I
L
R
K
I
M
G
-
N
---
T
L
A
T
Q
--
A
V
Q
E
I
K
---
H
S
L
---
D
H
G
R
K
-
T
G
G
R
L
--
L
M
F
G
-
V
-
G
V
---
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
-
A
L
G
M
A
I
G
M
F
S
--
L
G
T
A
F
Y
T
-
Q
-----
A
--
P
G
-
I
--
V
A
L
L
S
M
---
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
---
W
T
F
P
M
------
M
D
K
N
S
W
L
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
--
23
PsiBlast_CBE
84.83
38%
-138
- C2 -
4JA3
2
XYLE_ECOLI
B:
[7-471]
-------------------
S
S
Y
I
F
S
I
T
L
--
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
VAPQNLS
E
S
--------------
A
--------------
A
N
S
L
L
--------------
G
--------------
F
C
V
A
S
A
L
-----------
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
---
S
A
WPELGF
T
S
I
N
P
D
N
T
V
P
VY
L
------------------
A
---
G
Y
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
S
G
D
A
S
-
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
-
S
R
-
G
K
-
Q
E
Q
-
A
E
G
-
I
L
R
K
I
M
G
-
N
---
T
L
A
T
Q
--
A
V
Q
E
I
K
---
H
S
L
---
D
H
G
R
----------------
G
V
---
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
------
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
-
A
L
G
M
A
I
G
M
F
S
--
L
G
T
A
F
Y
T
-
Q
-----
A
--
P
G
-
I
--
V
A
L
L
S
M
---
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
---
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
---
W
T
F
P
M
------
M
D
KNS------
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
---------
1
PsiBlast_PDB
81.76
38%
-135
- C2 -
4JA4
1
XYLE_ECOLI
A:
[9-478]
---------------------
Y
I
F
S
I
T
L
--
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
VAPQNLS
E
S
--------------
A
--------------
A
N
S
L
L
--------------
G
--------------
F
C
V
A
S
A
L
-----------
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
---
S
A
W
PELGF
T
S
I
N
P
D
N
T
V
PVY
L
------------------
A
---
G
Y
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
S
G
D
A
S
-
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
-------
Q
E
Q
-
A
E
G
-
I
L
R
K
I
M
G
-
N
---
T
L
A
T
Q
--
A
V
Q
E
I
K
---
H
S
L
---
D
H
G-----------
M
F
G
-
V
-
G
V
---
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
-----------
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
-
A
L
G
M
A
I
G
M
F
S
--
L
G
T
A
F
Y
T
-
Q
-----
A
--
P
G
-
I
--
V
A
L
L
S
M
---
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
---
W
T
F
P
M
------
M
DKNSW------
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
--
47
Fugue
81.57
42%
-138
- C2 -
4QIQ
1
XYLE_ECOLI
A:
[7-470]
--------------------
S
Y
I
F
S
I
T
L
--
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
VAPQNLS
E
S
--------------
A
--------------
A
N
S
L
L
--------------
G
--------------
F
C
V
A
S
A
L
-----------
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
---
S
A
WPELGFTSINPDNTVPVY
L
------------------
A
---
G
Y
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
S
G
D
A
S
-
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
---------------------------
T
L
A
T
Q
--
A
V
Q
E
I
K
---
H
S
L
-------------
D
--
R
L
L
M
-
F
-
G
V
-
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
-
A
L
G
M
A
I
G
M
F
S
--
L
G
T
A
F
Y
T
-
Q
-----
A
--
P
G
-
I
--
V
A
L
L
S
M
---
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
---
W
T
F
P
M
------
M
DKN
S
W
L
V
A
H
F
H
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
---------
25
HHSearch
80.75
42%
-113
- C2 -
4GC0
4
XYLE_ECOLI
A:
[14-428]
--------------------------
T
L
--
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
VAPQNLS
E
S
--------------
A
--------------
A
N
S
L
L
--------------
G
--------------
F
C
V
A
S
A
L
-----------
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
---
S
A
------------------
W
PELGFTSINPDNTVPVYL
A
---
G
Y
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
S
G
D
A
S
-
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
-
S
R
-
G
K
-
Q
E
Q
-
A
E
G
-
I
L
R
K
I
M
G
-
N
---
T
L
A
T
Q
--
A
V
Q
E
I
K
---
H
S
L
---
D
H
--
G
-
R
K
T
G
G
--
R
L
L
M
---
F
G
V
G
V
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
F
K
T
L
G
A
S
T
D
I
A
L
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
-
A
L
G
M
A
I
G
M
F
S
--
L
G
T
A
F
Y
T
-
Q
-----
A
--
P
G
-
I
--
V
A
L
L
S
M
---
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
---
W
T
F
P
M
----------------------------------------------------------
28
HHSearch
80.21
30%
-120
- C2 -
4PYP
1
GTR1_HUMAN
A:
[10-455]
--------------------
G
R
L
M
L
A
V
G
--
G
A
V
L
G
S
L
Q
F
G
Y
N
T
G
V
I
N
A
P
Q
K
V
I
E
E
F
Y
--------
T
--------------
Q
T
W
V
H
R
YG
E
S
I
L
P
T
T
L
T
T
L
W
--------------
S
--------------
L
S
V
A
I
F
S
-----------
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
M
M
N
L
L
A
F
V
S
A
V
L
---
M
G
------------------
F
------------------
S
KLG
K
S
F
E
M
L
I
L
G
R
F
I
I
G
V
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
I
L
I
A
Q
V
F
G
L
D
S
I
M
-------
G
N
K
D
L
W
P
L
L
L
S
I
I
F
I
P
A
L
L
Q
C
I
V
L
P
F
C
P
E
S
P
R
F
L
L
-
I
N
R
N
E
-
E
N
R
-
A
K
S
-
V
L
K
K
L
R
G
-
T
---
A
D
V
T
H
--
D
L
Q
E
M
K
E
E
S
R
Q
M
---
M
R
-
E
K
-
K
V
T
I
L
--
E
L
F
R
S
P
-
A
Y
R
Q
P
I
L
I
A
V
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
S
I
F
E
K
A
G
V
Q
--
Q
P
V
Y
A
T
I
G
S
G
I
V
N
T
A
F
T
V
V
S
L
F
V
V
Q
R
A
G
R
R
T
L
H
L
I
G
-
L
A
G
M
A
G
C
A
I
L
--
M
T
I
A
L
A
L
-
L
E--
Q
-
L
PW
M
S
-
Y
--
L
S
I
V
A
I
---
F
G
F
V
A
F
F
E
V
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
I
A
V
A
G
F
S
N
W
T
S
N
F
I
V
G
---
M
C
F
Q
Y
------
V
------
E
Q
L
C
G
P
-
Y
V
F
I
I
F
T
V
L
L
V
L
F
F
I
F
T
Y
F
K
V
P
E
T
--------------
22
PsiBlast_CBE
79.43
38%
-105
- C2 -
4JA4
1
XYLE_ECOLI
B:
[9-478]
---------------------
Y
I
F
S
I
T
L
--
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
VAPQNLS
E
S
--------------
A
--------------
A
N
S
L
L
--------------
G
--------------
F
C
V
A
S
A
L
-----------
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
---
S
A
W
PELGF
T
S
I
N
P
DNPVY--
L
------------------
A
---
G
Y
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
S
G
D
A
S
-
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
-------
Q
E
Q
-
A
E
G
-
I
L
R
K
I
M
G
-
N
---
T
L
A
T
Q
--
A
V
Q
E
I
K
---
H
S
L
---
D
H
G-----------
M
F
G
-
V
-
G
V
---
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
------------
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
-
A
L
G
M
A
I
G
M
F
S
--
L
G
T
A
F
Y
T
-
Q
-----
A
--
P
G
-
I
--
V
A
L
L
S
M
---
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
---
W
T
F
P
M
------
M
DKNSW------
N
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
--
21
PsiBlast_CBE
79.08
38%
-92
- C2 -
4JA4
1
XYLE_ECOLI
C:
[9-478]
---------------------
Y
I
F
S
I
T
L
--
V
A
T
L
G
G
L
L
F
G
Y
D
T
A
V
I
S
G
T
V
E
S
L
N
T
V
F
VAPQNLSE
S
--------------
A
--------------
A
N
S
L
L
--------------
G
--------------
F
C
V
A
S
A
L
-----------
I
G
C
I
I
G
G
A
L
G
G
Y
C
S
N
R
F
G
R
R
D
S
L
K
I
A
A
V
L
F
F
I
S
G
V
G
---
S
A
WPELGFTSINPTVPVY--
L
------------------
A
---
G
Y
V
P
E
F
V
I
Y
R
I
I
G
G
I
G
V
G
L
A
S
M
L
S
P
M
Y
I
A
E
L
A
P
A
H
I
R
G
K
L
V
S
F
N
Q
F
A
I
I
F
G
Q
L
L
V
Y
C
V
N
Y
F
I
A
R
S
G
D
A
S
-
W
L
N
T
D
G
W
R
Y
M
F
A
S
E
C
I
P
A
L
L
F
L
M
L
L
Y
T
V
P
E
S
P
R
W
L
M
-------
Q
E
Q
-
A
E
G
-
I
L
R
K
I
M
G
-
N
---
T
L
A
T
Q
--
A
V
Q
E
I
K
---
H
S
L
---
D
H
G-----------
M
F
G
-
V
-
G
V
---
I
V
I
G
V
M
L
S
I
F
Q
Q
F
V
G
I
N
V
V
L
Y
Y
A
P
E
V
------------
L
Q
T
I
I
V
G
V
I
N
L
T
F
T
V
L
A
I
M
T
V
D
K
F
G
R
K
P
L
Q
I
I
G
-
A
L
G
M
A
I
G
M
F
S
--
L
G
T
A
F
Y
T
-
Q
-----
A
--
P
G
-
I
--
V
A
L
L
S
M
---
L
F
Y
V
A
A
F
A
M
S
W
G
P
V
C
W
V
L
L
S
E
I
F
P
N
A
I
R
G
K
A
L
A
I
A
V
A
A
Q
W
L
A
N
Y
F
V
S
---
W
T
F
P
M
------
M
DKN---------
G
F
S
Y
W
I
Y
G
C
M
G
V
L
A
A
L
F
M
W
K
F
V
P
E
T
K
G
K
T
L
E
E
L
E
A
L
W
--
8
PsiBlast_PDB
77.39
29%
-113
- C2 -
4ZW9
4
GTR3_HUMAN
A:
[39-485]
-------------------------------
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
--------
T
--------------
K
--------------
T
L
T
D
K
--------------
G
NAPPS
E
V
L
L
T
S
L
W
S
L
S
V
A
I
F
S
-----------
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
G
G
C
F
---
M
G
------------------
L
CKV---------------
A
---
K
S
V
E
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
------
F
I
-
L
G
S
E
E
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
L
-
I
N
-
R
K
-
E
E
E
N
A
K
Q
-
I
L
Q
R
L
W
G
T
Q
---
D
V
S
Q
D
I
Q
E
M
K
D
E
S
---
A
R
M
---
S
Q
-
E
K
-
Q
V
T
V
L
--
E
L
F
R
V
S
-
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
G
V
Q
E
P
--
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
-
L
G
G
M
A
F
C
S
T
L
--
M
T
V
S
L
L
L
-
K
---
D
-
N
--
Y
N
-
G
--
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
---
L
L
F
P
S
------
A
------
A
H
Y
L
G
-
A
Y
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
----
9
PsiBlast_PDB
76.92
29%
-113
- C2 -
4ZWB
1
GTR3_HUMAN
A:
[39-485]
-------------------------------
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
--------
T
--------------
K
--------------
T
L
T
D
K
--------------
G
NAPPS
E
V
L
L
T
S
L
W
S
L
S
V
A
I
F
S
-----------
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
G
G
C
F
---
M
G
------------------
L
CKV---------------
A
---
K
S
V
E
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
------
F
I
-
L
G
S
E
E
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
L
-
I
N
-
R
K
-
E
E
E
N
A
K
Q
-
I
L
Q
R
L
W
G
T
Q
---
D
V
S
Q
D
I
Q
E
M
K
D
E
S
---
A
R
M
---
S
Q
-
E
K
-
Q
V
T
V
L
--
E
L
F
R
V
S
-
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
G
V
Q
E
P
--
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
-
L
G
G
M
A
F
C
S
T
L
--
M
T
V
S
L
L
L
-
K
---
D
-
N
--
Y
N
-
G
--
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
---
L
L
F
P
S
------
A
------
A
H
Y
L
G
-
A
Y
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
----
7
PsiBlast_PDB
76.72
29%
-118
- C2 -
5C65
8
GTR3_HUMAN
A:
[17-463]
-------------------------------
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
--------
Q
--------------
K
--------------
T
L
T
D
K
--------------
G
NAPPS
E
V
L
L
T
S
L
W
S
L
S
V
A
I
F
S
-----------
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
G
G
C
F
---
M
G
------------------
L
C
KV---------------
A
---
K
S
V
E
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
------
F
I
-
L
G
S
E
E
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
L
-
I
N
-
R
K
-
E
E
E
N
A
K
Q
-
I
L
Q
R
L
W
G
T
Q
---
D
V
S
Q
D
I
Q
E
M
K
D
E
S
---
A
R
M
---
S
Q
-
E
K
-
Q
V
T
V
L
--
E
L
F
R
V
S
-
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
----
P
--
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
-
L
G
G
M
A
F
C
S
T
L
--
M
T
V
S
L
L
L
-
K
---
D
----------
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
---
L
L
F
P
S
------
A
------
A
H
Y
L
G
-
A
Y
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
----
6
PsiBlast_PDB
76.71
30%
-103
- C2 -
4PYP
1
GTR1_HUMAN
A:
[10-455]
--------------------
G
R
L
M
L
A
V
G
--
G
A
V
L
G
S
L
Q
F
G
Y
N
T
G
V
I
N
A
P
Q
K
V
I
E
E
F
Y
--------
T
Q
T
W
-----------
V
--------------
H
R
Y
G
E
--------------
S
--------------
I
L
P
T
T
L
T
T
L
W
S
L
S
V
A
I
F
S
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
M
M
N
L
L
A
F
V
S
A
V
L
M
G
F
S
K
------------------
L
------------------
G
---
K
S
F
E
M
L
I
L
G
R
F
I
I
G
V
Y
C
G
L
T
T
G
F
V
P
M
Y
V
G
E
V
S
P
T
A
L
R
G
A
L
G
T
L
H
Q
L
G
I
V
V
G
I
-------
L
I
A
Q
V
F
G
L
D
S
I
M
G
N
K
D
L
W
P
L
L
L
S
I
I
F
I
P
A
L
L
Q
C
I
V
L
P
F
C
P
E
S
P
R
F
L
L
I
N
R
-
N
E
-
E
N
R
-
A
K
S
-
V
L
K
K
L
R
G
-
T
ADV
T
H
D
L
Q
--
E
M
K
E
E
S
---
R
Q
M
---
M
R
-
E
K
-
K
V
T
I
L
--
E
L
F
R
S
P
-
A
Y
R
Q
P
I
L
I
A
V
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
S
I
F
E
K
A
G
V
Q
Q
P
V
--
Y
A
T
I
G
S
G
I
V
N
T
A
F
T
V
V
S
L
F
V
V
Q
R
A
G
R
R
T
L
H
L
I
G
-
L
A
G
M
A
G
C
A
I
L
M
T
I
A
L
A
L
L
E
-
Q
---
L
-
P
W-
M
S
-
Y
--
L
S
I
V
A
I
---
F
G
F
V
A
F
F
E
V
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
I
A
V
A
G
F
S
N
W
T
S
N
F
I
V
G
M
C
F
Q
Y
V
E
Q
------
L
------
C
G
----
P
Y
V
F
I
I
F
T
V
L
L
V
L
F
F
I
F
T
Y
F
K
V
P
E
T
--------------
10
PsiBlast_PDB
76.20
29%
-114
- C2 -
4ZWC
3
GTR3_HUMAN
A:
[39-485]
-------------------------------
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
--------
T
--------------
K
--------------
T
L
T
D
K
--------------
G
NAPPS
E
V
L
L
T
S
L
W
S
L
S
V
A
I
F
S
-----------
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
G
G
C
F
---
M
G
------------------
L
CKV---------------
A
---
K
S
V
E
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
------
F
I
-
L
G
S
E
E
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
L
-
I
N
-
R
K
-
E
E
E
N
A
K
Q
-
I
L
Q
R
L
W
G
T
Q
---
D
V
S
Q
D
I
Q
E
M
K
D
E
S
---
A
R
M
---
S
Q
-
E
K
-
Q
V
T
V
L
--
E
L
F
R
V
S
-
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
G
V
Q
E
P
--
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
-
L
G
G
M
A
F
C
S
T
L
--
M
T
V
S
L
L
L
-
K
---
D
-
N
--
Y
N
-
G
--
M
S
F
V
C
I
G
A
I
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
---
L
L
F
P
S
------
A
------
A
H
Y
L
G
-
A
Y
V
F
I
I
F
T
G
F
L
I
T
F
L
A
F
T
F
F
K
V
P
E
T
R
G
R
T
F
E
D
I
T
R
----
29
HHSearch
75.77
29%
-119
- C2 -
4ZW9
4
GTR3_HUMAN
A:
[32-453]
----------------------
L
I
F
A
I
T
--
V
A
T
I
G
S
F
Q
F
G
Y
N
T
G
V
I
N
A
P
E
K
I
I
K
E
F
I
--------
T
K
T
L
T
D
K
GNAPPS
E
V
L
--------------
L
T
S
L
W
--------------
S
--------------
L
S
V
A
I
F
S
-----------
V
G
G
M
I
G
S
F
S
V
G
L
F
V
N
R
F
G
R
R
N
S
M
L
I
V
N
L
L
A
V
T
G
G
C
F
---
M
G
------------------
L
CKV---------------
A
---
K
S
V
E
M
L
I
L
G
R
L
V
I
G
L
F
C
G
L
C
T
G
F
V
P
M
Y
I
G
E
I
S
P
T
A
L
R
G
A
F
G
T
L
N
Q
L
G
I
V
V
G
I
L
V
A
Q
I
F
G
L
E
F
I
L
G
-------
S
E
E
L
W
P
L
L
L
G
F
T
I
L
P
A
I
L
Q
S
A
A
L
P
F
C
P
E
S
P
R
F
L
L
-
I
N
-
R
K
-
E
E
E
N
A
K
Q
-
I
L
Q
R
L
W
G
-
T
---
Q
D
V
S
Q
--
D
I
Q
E
M
K
D
E
S
A
R
M
---
S
Q
-
E
K
-
Q
V
T
V
L
--
E
L
F
R
-
V
S
S
Y
R
Q
P
I
I
I
S
I
V
L
Q
L
S
Q
Q
L
S
G
I
N
A
V
F
Y
Y
S
T
G
I
F
K
D
A
G
--
V
Q
E
P
I
Y
A
T
I
G
A
G
V
V
N
T
I
F
T
V
V
S
L
F
L
V
E
R
A
G
R
R
T
L
H
M
I
G
-
L
G
G
M
A
F
C
S
T
L
--
M
T
V
S
L
L
L
-
K
DNY
N
-
G
--
M
S
-
F
--
V
C
I
G
A
I
---
L
V
F
V
A
F
F
E
I
G
P
G
P
I
P
W
F
I
V
A
E
L
F
S
Q
G
P
R
P
A
A
M
A
V
A
G
C
S
N
W
T
S
N
F
L
V
G
---
L
L
F
P
S
------
A
------
A
H
Y
L
G
A
Y
V
-------------------------------------
24
HHSearch
75.53
28%
-132
- C2 -
4YB9
-
GTR5_BOVIN
D:
[28-462]
----------------------------------
S
S
F
Q
Y
G
Y
N
V
A
A
I
N
S
P
S
E
F
M
K
D
F
Y
--------
A
--------------
Y
TYYDRVGEYMNEFY
L
T
L
L
W
--------------
S
--------------
V
T
V
S
M
F
P
-----------
F
G
G
F
L
G
S
L
M
V
G
P
L
V
N
N
L
G
R
K
G
T
L
L
F
N
N
I
F
S
I
V
P
A
L
L
---
M
G
------------------
F
------------------
S
ELA
K
S
F
E
M
I
I
V
A
R
V
L
V
G
I
C
A
G
L
S
S
N
V
V
P
M
Y
L
G
E
L
A
P
K
N
W
R
G
A
L
G
V
V
P
Q
L
F
I
T
I
G
I
L
V
A
Q
I
F
G
L
R
S
L
L
-------
A
N
E
E
G
W
P
I
L
L
G
L
T
G
I
P
A
V
L
Q
L
L
F
L
P
F
F
P
E
S
P
R
Y
L
L
-
I
Q
-
K
K
D
E
A
A
-
A
K
S
-
A
L
R
R
L
-----------
A
--
E
I
E
E
I
L
---
E
E
D
RAE
K
A
-
V
G
-
F
I
S
V
L
--
K
L
F
K
M
R
-
S
L
R
W
Q
V
I
S
I
I
V
L
M
A
G
Q
Q
L
S
G
V
N
A
I
Y
Y
Y
A
D
Q
I
Y
L
S
A
G
V
N
E
D
D
V
Q
Y
V
T
A
G
T
G
A
V
N
V
L
I
T
V
C
A
I
F
V
V
E
L
M
G
R
R
F
L
L
L
L
G
-
F
S
V
C
F
T
A
C
C
V
--
L
T
G
A
L
A
L
-
Q
---
D
V
I
S-
W
M
P
Y
--
V
S
I
A
C
V
---
I
S
Y
V
I
G
H
A
L
G
P
S
P
I
P
A
L
L
V
T
E
I
F
L
Q
S
S
R
P
A
A
Y
M
V
A
G
T
V
H
W
L
S
N
F
T
V
G
---
L
V
F
P
F
------
I
------
Q
V
G
L
G
A
-
Y
S
F
V
I
F
A
V
I
C
L
L
T
T
V
Y
I
F
L
I
I
P
E
---------------
27
HHSearch
74.53
37%
-160
- C2 -
4LDS
-
?
A:
[14-412]
---------------------------------
L
G
G
L
L
Y
G
Y
D
N
G
V
I
S
G
A
L
L
F
I
H
K
D
I
--------
P
--------------
L
--------------
N
S
T
T
E
--------------
G
--------------
I
V
V
S
S
M
L
-----------
I
G
A
I
V
G
A
G
S
S
G
P
L
A
D
K
L
G
R
R
R
L
V
M
L
I
A
I
V
F
I
I
G
A
L
I
---
L
A
------------------
A
------------------
S
---
T
N
L
A
L
L
I
I
G
R
L
I
I
G
L
A
V
G
G
S
M
S
T
V
P
V
Y
L
S
E
M
A
P
T
E
Y
R
G
S
L
G
S
L
N
Q
L
M
I
T
I
G
I
L
A
A
Y
L
V
N
Y
A
F
A
D
---------
I
E
G
W
R
W
M
L
G
L
A
V
V
P
S
V
I
L
L
V
G
I
Y
F
M
P
E
S
P
R
W
L
L
-
E
N
-
R
N
-
E
E
A
-
A
R
Q
-
V
M
K
I
T
Y
D
-
D
---
S
E
I
D
K
--
E
L
K
E
M
----
K
E
----
I
N
-
A
I
-
S
E
S
T
W
--
T
V
I
K
-
S
P
W
L
G
R
I
L
I
V
G
C
I
F
A
I
F
Q
Q
F
I
G
I
N
A
V
I
F
Y
S
S
S
I
F
A
K
A
G
L
G
E
A
A
S
I
L
G
S
V
G
I
G
T
I
N
V
L
V
T
I
V
A
I
F
V
V
D
K
I
D
R
K
K
L
L
V
G
G
-
N
I
G
M
I
A
S
L
L
I
--
M
A
I
L
I
W
T
I
G
I--
A
-
S
--
S
A
-
W
--
I
I
I
V
C
L
---
S
L
F
I
V
F
F
G
I
S
W
G
P
V
L
W
V
M
L
P
E
L
F
P
M
R
A
R
G
A
A
T
G
I
S
A
L
V
L
N
I
G
T
L
I
V
S
---
L
F
F
P
I
------
L
------
S
D
A
L
S
T
E
W
V
F
L
I
F
A
F
I
G
V
---------------------------
11
PsiBlast_PDB
73.99
28%
-95
- C2 -
4YB9
-
GTR5_BOVIN
D:
[19-462]
-------------------------
L
A
T
LI
A
A
F
G
S
S
F
Q
Y
G
Y
N
V
A
A
I
N
S
P
S
E
F
M
K
D
F
Y
--------
A
--------------
Y
--------------
T
Y
Y
D
R
VGEYMNEFYLTLLW
S
--------------
V
T
V
S
M
F
P
-----------
F
G
G
F
L
G
S
L
M
V
G
P
L
V
N
N
L
G
R
K
G
T
L
L
F
N
N
I
F
S
I
V
P
A
L
L
MGF
S
E
------------------
L
------------------
A
---
K
S
F
E
M
I
I
V
A
R
V
L
V
G
I
C
A
G
L
S
S
N
V
V
P
M
Y
L
G
E
L
A
P
K
N
W
R
G
A
L
G
V
V
P
Q
L
F
I
T
I
G
I
L
V
A
Q
I
F
G
L
R
S
L
L
A
N
-------
E
E
G
W
P
I
L
L
G
L
T
G
I
P
A
V
L
Q
L
L
F
L
P
F
F
P
E
S
P
R
Y
L
L
-
I
Q
-
K
K
-
D
E
A
-
A
A
K
S
A
L
R
R
L
-----------
A
--
E
I
E
E
I
L
---
E
E
D
---
R
A
-
E
K
A
V
G
F
I
S
VL
K
L
F
K
M
R
-
S
L
R
W
Q
V
I
S
I
I
V
L
M
A
G
Q
Q
L
S
G
V
N
A
I
Y
Y
Y
A
D
Q
I
Y
L
S
A
G
V
N
E
D
D
V
Q
Y
V
T
A
G
T
G
A
V
N
V
L
I
T
V
C
A
I
F
V
V
E
L
M
G
R
R
F
L
L
L
L
G
F
S
V
C
F
T
A
C
C
V
L
--
T
G
A
L
A
L
Q
-
D
---
V
-
I
--
S
W
-
M
PY
V
S
I
A
C
V
---
I
S
Y
V
I
G
H
A
L
G
P
S
P
I
P
A
L
L
V
T
E
I
F
L
Q
S
S
R
P
A
A
Y
M
V
A
G
T
V
H
W
L
S
N
F
T
V
G
---
L
V
F
P
F
------
I
------
Q
V
G
L
G
-
A
Y
S
F
V
I
F
A
V
I
C
L
L
T
T
V
Y
I
F
L
I
I
P
E
---------------