@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu34090: (2016-07-27 )
MMKEAVTVSNVTKHFQRKTAVNNISFSIEKGEIAAILGPNGAGKTTVVSMILGLLKPSEGEIKLFNRVPDDQQVREKIGVMLQEVSVMPGLKVDEILELFRSYYPNPLSMKELVSLTALTKEDLKTRAEKLSGGQKRRLSFALALAGNPELLILDEPTVGMDTSSRHRFWQTIHGLSDQGKTIIFSTHYLQEADDAAQRILFFTEGQLVADGSPMQIRSRIQKQSVSFTLHSSESLERLSCHPEVERVIHEHERTIIQTSNTDKVLALIFQENIHARDIRIEQATLDEAFRQLADGNREAM
Atome Classification :
(25 SA)
.........10......-----.----.20........30........40........50........60--.-----.----.----.--.---.-----.----.70.--.-.---..-...80..--......90....---....--100.-...-----.-----..-----110------...-----------......120--.....----.-----..----130........140.......150.......160.......170.....-..-.-180........190.......200.......210....----------------...220.......230.......----240--..--.....250.......260.......270.......280.......290.......300
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MMKEA
V
T
V
S
N
V
T
K
H
F
Q
R
-----K----TAVNN
I
S
F
S
I
EKG
E
I
A
A
I
LGPNGA
G
K
T
T
V
V
S
M
I
L
G
LLKPSEG
E
--
I
-----
K
----
L
----
F
--N---R-----V----P
D
D
Q
--
Q
-
V
---
R
E
-
K
I
G
V
M
L
Q
--
E
V
SVMPGL
K
V
D
E
---
I
L
E
L
--
F
R
S
Y-YPN-----P-----L
S
-----
M
--------
K
E
L
-----------
V
S
L
T
A
L
T
K
---
E
D
L
K
T
----
R
-----
A
E
----K-LSGGQ
K
R
R
L
S
F
A
L
A
LAGNP
E
L
L
I
L
DEPTVGMDTS
S
R
H
R
F
W
Q
-
T
I
HGL-SD-Q-G
K
-
T
I
I
F
S
T
H
Y
L
Q
E
A
D
D
A
A
Q
R
I
L
F
F
TE
G
Q
L
VADGS
P
M
Q
----------------
I
R
S
R
I
Q
KQ
S
V
S
F
T
LHSSES
L
E
RL----SC
H
--
P
E
--
V
E
R
V
I
H
E
HER
T
I
I
QTSNT
D
K
V
L
A
L
I
F
QENIHA
R
D
I
R
I
E
Q
A
T
L
D
E
A
F
R
Q
L
ADGNREAM
2
PsiBlast_PDB
79.95
32%
-7
- C1 -
4YER
4
?
A:
[6-302]
-----
I
V
V
E
N
L
V
K
K
F
G
D
-----
F
----
E
A
V
K
G
V
S
F
S
V
K
K
G
E
I
F
A
F
L
G
P
N
G
A
G
K
T
T
T
I
H
M
L
T
T
L
L
K
P
T
S
G
K
A
W
V
-----
A
----
G
----
H
--
D
---
V
-----
L
----
K
E
P
R
--
E
-
V
---
R
R
-
K
I
G
I
V
F
Q
--
D
Q
S
L
D
R
E
L
T
A
Y
E
N
M
Y
I
H
G
K
--
I
Y
G
Y
-
G
G
E
-----
K
-----
L
K
-----
K
--------
R
I
L
-----------
E
L
L
E
F
V
E
L
---
L
E
F
K
D
----
K
-----
P
V
----
K
T
F
S
G
G
M
A
R
R
L
E
I
A
R
S
L
I
H
E
P
E
V
L
F
L
D
E
P
T
I
G
L
D
P
H
T
R
A
H
M
W
E
-
Y
I
S
K
M
K
K
E
-
H
-
N
M
-
T
I
F
L
T
T
H
Y
M
D
E
A
E
Q
L
A
D
R
V
A
I
I
D
H
G
K
I
I
A
L
G
T
P
T
E
----------------
L
K
R
M
V
G
K
E
I
I
Y
V
R
----------DFIE
S
C
R
K
L
P
D
G
R
L
E
L
N
V
E
D
------------------------
I
E
E
I
T
Y
H
K
P
T
L
N
D
V
F
L
H
L
--------
1
PsiBlast_PDB
75.86
33%
-22
- C1 -
1VPL
2
?
A:
[15-242]
----
A
V
V
V
K
D
L
R
K
R
I
G
K
-----
K
----
E
I
L
K
G
I
S
F
E
I
E
E
G
E
I
F
G
L
I
G
P
N
G
A
G
K
T
T
T
L
R
I
I
S
T
L
I
K
P
S
S
G
I
--
V
-----
T
----
V
----
F
GK
N
---
V
-----
V
----
E
E
P
H
--
E
-
V
---
R
K
-
L
I
S
Y
L
P
E
--
E
A
G
A
Y
R
N
M
Q
G
I
E
---
Y
L
R
F
--
V
A
G
F
-
Y
A
S
-----
S
-----
S
S
E
I
E
E
-
M
--------
V
E
R
-----------
A
T
E
I
A
G
L
G
---
E
K
I
K
D
----
R
-----
V
S
----
T
-
Y
S
K
G
M
V
R
K
L
L
I
A
R
A
L
M
V
N
P
R
L
A
I
L
D
E
P
T
S
G
L
D
V
L
N
A
R
E
V
R
K
-
I
L
K
Q
A
-
S
Q
-
E
-
G
L
-
T
I
L
V
S
S
H
N
M
L
E
V
E
F
L
C
D
R
I
A
L
I
H
N
G
T
I
V
E
T
G
T
V
E
E
----------------
L
K
E
R
Y
K
A
Q
N
I
-----------------------------------------------------------------------------------
4
PsiBlast_PDB
71.83
29%
-47
- C1 -
4YMT
-
?
J:
[2-230]
-----
I
F
V
N
D
V
Y
K
N
F
G
S
-----
L
----
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
--
V
FIDGV
K
----
I
----
N
--
N
---
G
-----
K
----
V
N
I
N
--
K
-
V
---
R
Q
-
K
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
---
N
I
T
L
---------
A
-----
P
-----
V
K
-----
V
--------
K
K
M
NKKEAEE----
L
A
V
D
L
L
A
K
---
V
G
L
L
D
----
K
-----
K
D
QYPI
K
-
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
-
V
M
K
Q
L
-
A
N
-
E
-
G
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
----------------
I
F
Y
R
A
K
N
E
-------------------------------------------------------------------------------------
5
PsiBlast_PDB
70.75
29%
-44
- C1 -
4YMU
2
?
J:
[2-230]
-----
I
F
V
N
D
V
Y
K
N
F
G
S
-----
L
----
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
--
V
FIDGV
K
----
I
----
N
--
N
---
G
-----
K
----
V
N
I
N
--
K
-
V
---
R
Q
-
K
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
---
N
I
T
L
---------
A
-----
P
-----
V
K
-----
V
--------
K
K
M
NKKEAEE----
L
A
V
D
L
L
A
K
---
V
G
L
L
D
----
K
-----
K
D
QYPI
K
-
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
-
V
M
K
Q
L
-
A
N
-
E
-
G
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
----------------
I
F
Y
R
A
K
N
E
-------------------------------------------------------------------------------------
6
PsiBlast_PDB
70.57
29%
-45
- C1 -
4YMV
1
?
J:
[2-230]
-----
I
F
V
N
D
V
Y
K
N
F
G
S
-----
L
----
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
--
V
FIDGV
K
----
I
----
N
--
N
---
G
-----
K
----
V
N
I
N
--
K
-
V
---
R
Q
-
K
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
---
N
I
T
L
---------
A
-----
P
-----
V
K
-----
V
--------
K
K
M
NKKEAEE----
L
A
V
D
L
L
A
K
---
V
G
L
L
D
----
K
-----
K
D
QYPI
K
-
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
-
V
M
K
Q
L
-
A
N
-
E
-
G
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
----------------
I
F
Y
R
A
K
N
E
-------------------------------------------------------------------------------------
7
PsiBlast_PDB
70.39
29%
-47
- C1 -
4YMW
-
?
J:
[2-230]
-----
I
F
V
N
D
V
Y
K
N
F
G
S
-----
L
----
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
--
V
FIDGV
K
----
I
----
N
--
N
---
G
-----
K
----
V
N
I
N
--
K
-
V
---
R
Q
-
K
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
---
N
I
T
L
---------
A
-----
P
-----
V
K
-----
V
--------
K
K
M
NKKEAEE----
L
A
V
D
L
L
A
K
---
V
G
L
L
D
----
K
-----
K
D
QYPI
K
-
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
-
V
M
K
Q
L
-
A
N
-
E
-
G
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
----------------
I
F
Y
R
A
K
N
E
-------------------------------------------------------------------------------------
3
PsiBlast_PDB
70.01
29%
-48
- C1 -
4YMS
-
?
J:
[2-230]
-----
I
F
V
N
D
V
Y
K
N
F
G
S
-----
L
----
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
--
V
FIDGV
K
----
I
----
N
--
N
---
G
-----
K
----
V
N
I
N
--
K
-
V
---
R
Q
-
K
V
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
---
N
I
T
L
---------
A
-----
P
-----
V
K
-----
V
--------
K
K
M
NKKEAEE----
L
A
V
D
L
L
A
K
---
V
G
L
L
D
----
K
-----
K
D
QYPI
K
-
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
-
V
M
K
Q
L
-
A
N
-
E
-
G
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
----------------
I
F
Y
R
A
K
N
E
-------------------------------------------------------------------------------------
8
PsiBlast_PDB
68.38
31%
-67
- C1 -
2YYZ
3
?
A:
[3-221]
----
S
I
R
V
V
N
L
K
K
Y
F
G
K
-----
V
----
K
A
V
D
G
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
P
T
S
G
E
--
I
-----
Y
FDDV
L
----
V
--
N
---
D
-----
I
----
P
--
P
--
K
-
Y
---
R
E
--
V
G
M
V
F
Q
--
N
Y
A
L
Y
P
H
M
T
V
F
E
---
N
I
A
F
---------------
P
-----
L
R
-----
A
--------
R
R
I
SKD
E
V
E
K
R
V
V
E
I
A
R
K
L
L
I
D
---
N
L
L
D
R
----
K
-----
P
T
----
Q
-
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
P
K
V
L
L
F
D
E
P
L
S
N
L
D
A
N
L
R
M
I
M
R
A
-
E
I
K
H
L
-
Q
Q
-
E
L
G
I
-
T
S
V
Y
V
T
H
D
Q
A
E
A
M
T
M
A
S
R
I
A
V
F
N
Q
G
K
L
V
Q
Y
G
T
P
D
E
----------------
V
--------------------------------------------------------------------------------------------
60
HHSearch
65.94
31%
-24
- C1 -
2YYZ
3
?
A:
[2-225]
---
P
S
I
R
V
V
N
L
K
K
Y
F
G
K
-----
V
----
K
A
V
D
G
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
P
T
S
G
E
--
I
-----
Y
----
F
----
D
--
D
---
V
-----
L
----
V
N
D
I
--
P
P
K
---
Y
R
-
E
V
G
M
V
F
Q
--
N
Y
A
L
Y
P
H
M
T
V
F
E
---
N
I
A
F
--
P
L
R
A
-
R
R
I
SKD
E
V
E
-----
K
R
-----
V
--------
V
E
I
-----------
A
R
K
L
L
I
D
N
----
L
L
D
R
----
K
-----
P
T
----
Q
-
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
P
K
V
L
L
F
D
E
P
L
S
N
L
D
A
N
L
R
M
I
M
R
A
-
E
I
K
H
L
-
Q
Q
E
L
-
G
I
-
T
S
V
Y
V
T
H
D
Q
A
E
A
M
T
M
A
S
R
I
A
V
F
N
Q
G
K
L
V
Q
Y
G
T
P
D
E
----------------
V
Y
D
S
P
----------------------------------------------------------------------------------------
38
PsiBlast_CBE
64.59
31%
-2
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[2-231]
--
T
A
A
L
H
I
G
H
L
S
K
S
F
Q
N
-----
T
----
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
--
I
-----
S
----
L
----
S
--
G
---
K
-----
T
IFSK
N
T
N
L
--
P
-
V
---
R
E
R
R
L
G
Y
L
V
Q
--
E
G
V
L
F
P
H
L
T
V
Y
R
---
N
I
A
Y
--
G
L
G
N
-
G
K
G
-----
R
-----
T
A
Q
E
R
Q
R
I
--------
E
A
M
-----------
L
E
L
T
G
I
S
-----
E
L
A
G
----
R
Y----
P
H
----
E
-
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
-
R
A
-
N
-
G
K
-
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
----------------
L
--------------------------------------------------------------------------------------------
37
PsiBlast_CBE
63.67
31%
-3
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[2-226]
--
T
A
A
L
H
I
G
H
L
S
K
S
F
Q
N
-----
T
----
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
--
I
-----
S
----
L
----
S
--
G
---
K
-----
T
IFSK
N
T
N
L
--
P
-
V
---
R
E
R
R
L
G
Y
L
V
Q
--
E
G
V
L
F
P
H
L
T
V
Y
R
---
N
I
A
Y
--
G
L
G
N
-
G
K
G
-----
R
-----
T
A
QERQR
I
--------
E
A
M
-----------
L
E
L
T
G
I
S
-----
E
L
A
G
----
R
Y----
P
H
----
E
-
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
-
R
A
-
N
-
G
K
-
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
----------------
L
--------------------------------------------------------------------------------------------
14
PsiBlast_PDB
63.14
27%
45
- C1 -
4HLU
2
ECFA2_THEMA
A:
[5-266]
-----
I
E
V
V
N
V
S
H
I
F
H
R
GTPLE
K
----
K
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
D
--
V
-----
L
----
Y
----
D
--
G
---
E
-----
R
----
K
K
G
Y
--
E
-
I
---
R
R
-
N
I
G
I
A
F
Q
YP
E
D
Q
F
F
A
E
R
V
F
D
E
---
V
A
F
A
--
V
K
N
F
-
Y
P
D
RDP
V
-
P
-----
L
------
V
--------
K
K
A
-----------
M
E
F
V
G
L
D
F
---
D
S
F
K
D
----
R
-----
V
P
----
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
L
R
-
I
V
E
K
W
-
K
T
-
L
-
G
K
-
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
K
G
K
K
V
F
D
G
T
R
M
E
F
L
E
K
YDPRFFT
S
K
M
L
V
M
R
R
L
V
L
K
G
E
D
P
F
S
M
S
D
D
E
L
L
E
R
V
----
C
-----------------------------------------------------------------
20
PsiBlast_PDB
62.85
32%
-25
- C1 -
1V43
-
?
A:
[13-239]
-----
V
K
L
E
N
L
T
K
R
F
G
N
-----
F
----
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
--
I
-----
Y
----
F
----
G
--
D
---
R
DVTYL
P
----
P
K
D
R
--
N
---------
I
S
M
V
F
Q
--------
H
M
T
V
Y
E
---
N
I
A
F
PL-
K
K
F
-
P
K
D
-----
E
-----
I
D
-----
K
--------
R
V
R
-----------
W
A
A
E
L
L
Q
I
---
E
E
L
L
N
----
R
Y----
P
A
----
Q
-
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
-
E
I
K
K
L
-
Q
Q
-
K
-
L
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
----------------
V
Y
L
R
-----------------------------------------------------------------------------------------
19
PsiBlast_PDB
62.76
32%
-25
- C1 -
1VCI
1
?
A:
[13-239]
-----
V
K
L
E
N
L
T
K
R
F
G
N
-----
F
----
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
--
I
-----
Y
----
F
----
G
--
D
---
R
DVTYL
P
----
P
K
D
R
--
N
---------
I
S
M
V
F
Q
--------
H
M
T
V
Y
E
---
N
I
A
F
PL-
K
K
F
-
P
K
D
-----
E
-----
I
D
-----
K
--------
R
V
R
-----------
W
A
A
E
L
L
Q
I
---
E
E
L
L
N
----
R
Y----
P
A
----
Q
-
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
-
E
I
K
K
L
-
Q
Q
-
K
-
L
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
----------------
V
Y
L
R
-----------------------------------------------------------------------------------------
61
HHSearch
62.59
26%
-33
- C1 -
3RLF
3
MALK_ECOLI
A:
[2-226]
---
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
-----
V
----
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
--
L
-----
F
----
I
----
G
--
E
---
K
-----
R
----
M
N
D
T
--
P
P
A
---
E
R
-
G
V
G
M
V
F
Q
--
S
Y
A
L
Y
P
H
L
S
V
A
E
---
N
M
S
F
--
G
L
K
L
-
A
G
A
K
K
E
V
I
N
-----
Q
R
-----
V
--------
N
Q
V
-----------
A
E
V
L
Q
L
A
H
----
L
L
D
R
----
K
-----
P
K
----
A
-
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
-
E
I
S
R
L
-
H
K
R
L
-
G
R
-
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
----------------
L
Y
H
Y
P
A
---------------------------------------------------------------------------------------
73
HHSearch
62.50
24%
-44
- C1 -
4RVC
-
?
A:
[2-226]
---
T
L
L
E
V
K
D
L
S
G
G
Y
T
A
-----
Q
----
N
V
L
E
D
V
T
F
V
V
D
R
G
E
M
V
A
L
I
G
L
N
G
A
G
K
S
T
T
I
K
H
I
I
G
L
M
E
P
R
R
G
A
--
I
-----
S
----
I
----
N
--
G
---
Y
-----
R
----
L
A
D
G
P
E
T
-
Y
---
R
R
-
Q
F
A
Y
I
P
E
--
T
P
V
L
Y
E
E
L
T
L
E
E
---
H
L
R
L
--
A
A
M
A
-
Y
G
L
-----
S
E
A
E
Y
E
R
R
-----
L
--------
P
P
L
-----------
L
R
E
F
R
L
E
R
----
R
L
S
S
----
F
-----
P
A
----
H
-
F
S
K
G
M
K
Q
K
V
M
I
V
C
A
F
L
L
E
P
P
L
Y
I
I
D
E
P
F
L
G
L
D
P
L
A
I
H
A
L
L
E
-
R
M
N
E
Q
-
K
A
-
K
-
G
A
-
G
I
L
L
S
T
H
I
L
A
T
A
E
R
Y
C
D
S
F
V
I
L
H
N
G
R
V
K
A
K
G
T
L
D
D
----------------
I
R
R
Q
F
G
---------------------------------------------------------------------------------------
58
HHSearch
61.42
32%
-24
- C1 -
1V43
-
?
A:
[10-240]
--
M
V
E
V
K
L
E
N
L
T
K
R
F
G
N
-----
F
----
T
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
--
I
-----
Y
----
F
----
G
--
D
---
R
-----
D
----
V
T
Y
L
--
P
P
K
---
D
R
-
N
I
S
M
V
F
Q
--------
H
M
T
V
Y
E
---
N
I
A
F
--
P
L
---
K
K
F
P
K
D
E
I
D
-----
K
R
-----
V
--------
R
W
A
-----------
A
E
L
L
Q
I
E
E
----
L
L
N
R
----
Y
-----
P
A
----
Q
-
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
-
E
I
K
K
L
-
Q
Q
K
L
-
K
V
-
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
----------------
V
Y
L
R
P
----------------------------------------------------------------------------------------
57
HHSearch
61.28
30%
-23
- C1 -
2IT1
-
?
A:
[3-224]
----
E
I
K
L
E
N
I
V
K
K
F
G
N
-----
F
----
T
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
--
I
-----
Y
----
F
----
D
--
E
---
K
-----
D
----
V
T
E
L
--
P
P
K
---
D
R
-
N
V
G
L
V
F
Q
--
N
W
A
L
Y
P
H
M
T
V
Y
K
---
N
I
A
F
--
P
L
E
L
-
R
K
A
-----
P
R
E
E
I
D
K
K
-----
V
--------
R
E
V
-----------
A
K
M
L
H
I
D
K
----
L
L
N
R
----
Y
-----
P
W
----
Q
-
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
-
E
L
K
R
L
-
Q
K
E
L
-
G
I
-
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
----------------
V
Y
Y
K
-----------------------------------------------------------------------------------------
54
HHSearch
60.93
28%
-31
* C1 *
4TQU
-
?
S:
[2-225]
--
V
A
S
V
S
I
Q
N
V
V
K
R
Y
D
K
-----
T
----
T
V
V
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
I
S
G
G
T
--
I
-----
R
----
I
----
D
--
G
---
R
-----
V
----
I
N
D
L
--
A
P
K
---
D
R
-
D
V
A
M
V
F
Q
--
N
Y
A
L
Y
P
H
L
N
V
R
D
---
N
I
S
F
--
G
L
R
L
-
K
R
T
-----
K
KSVID
A
A
-----
V
--------
K
T
A
-----------
A
D
I
L
G
L
Q
P
----
L
L
E
R
----
K
-----
P
S
----
D
-
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
T
Q
M
R
A
-
E
I
K
R
L
-
H
Q
R
L
-
G
T
-
T
V
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
R
I
V
V
M
R
D
G
L
I
E
Q
I
G
K
P
M
D
----------------
L
F
L
H
-----------------------------------------------------------------------------------------
15
PsiBlast_PDB
60.58
27%
42
- C1 -
4ZIR
5
ECFA2_THEMA
A:
[4-265]
-----
I
E
V
V
N
V
S
H
I
F
H
R
GTPLE
K
----
K
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
D
--
V
-----
L
----
Y
----
D
--
G
---
E
-----------
K
G
Y
--
E
-
I
---
R
R
-
N
I
G
I
A
F
Q
YP
E
D
Q
F
F
A
E
R
V
F
D
E
---
V
A
F
A
--
V
K
N
F
-
Y
P
D
RDP
V
-
P
-----
L
------
V
--------
K
K
A
-----------
M
E
F
V
G
L
D
F
---
D
S
F
K
D
----
R
-----
V
P
----
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
L
R
-
I
V
E
K
W
-
K
T
-
L
-
G
K
-
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
K
G
K
K
V
F
D
G
T
R
M
E
F
L
E
KYDPRFFT
S
K
M
L
V
M
R
R
L
V
L
K
G
E
D
P
F
S
M
S
D
D
E
L
L
E
R
V
----
C
-----------------------------------------------------------------
21
PsiBlast_CBE
54.30
31%
41
- C1 -
3TIF
7
Y796_METJA
B:
[2-223]
-----
V
K
L
K
N
V
T
K
T
Y
K
M
-----
G
EEII
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
--
V
-----
Y
----
I
DNIK
T
--
N
---
D
-----
L
----
D
D
D
E
--
L
-
T
KIR
R
D
-
K
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
---
N
V
E
L
--
P
L
I
F
K
Y
R
G
-----
A
-----
M
S
-----
G
--------
E
E
R
RK---------
R
A
L
E
C
L
K
M
---
A
E
L
E
E
----
R
FANHK
P
N
----
Q
-
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
-
L
L
K
K
L
-
N
E
-
E
D
G
K
-
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
---------------------------------------------------------------------------------------------------------------------
53
HHSearch
50.80
30%
27
- C1 -
4YER
4
?
A:
[2-308]
-
M
E
D
I
I
V
V
E
N
L
V
K
K
F
G
D
-----
F
----
E
A
V
K
G
V
S
F
S
V
K
K
G
E
I
F
A
F
L
G
P
N
G
A
G
K
T
T
T
I
H
M
L
T
T
L
L
K
P
T
S
G
K
--
A
-----
W
----
V
----
A
--
G
---
H
-----
D
----
V
L
K
E
P
R
E
-
V
---
R
R
-
K
I
G
I
V
F
Q
--
D
Q
S
L
D
R
E
L
T
A
Y
E
---
N
M
Y
I
--
H
G
K
I
-
Y
G
Y
-----
G
G
E
K
L
K
K
R
-----
I
--------
L
E
L
-----------
L
E
F
V
E
L
L
E
----
F
K
D
K
----
P
-----
V
K
----
T
-
F
S
G
G
M
A
R
R
L
E
I
A
R
S
L
I
H
E
P
E
V
L
F
L
D
E
P
T
I
G
L
D
P
H
T
R
A
H
M
W
E
-
Y
I
S
K
M
-
K
K
E
H
-
N
M
-
T
I
F
L
T
T
H
Y
M
D
E
A
E
Q
L
A
D
R
V
A
I
I
D
H
G
K
I
I
A
L
G
T
P
T
E
----------------
L
K
R
M
V
G
K
E
I
I
Y
V
R
---------------
D
F
--
I
E
--
S
C
R
-
K
L
P
D
G
R
L
E
L
N
V
E
D
--------------
I
E
E
I
T
Y
H
K
P
T
L
N
D
V
F
L
H
L
T
G
R
E
L
R
--
44
PsiBlast_CBE
40.17
31%
2
- C1 -
4AYW
1
ABCBA_HUMAN
A:
[393-579]
-------------------------------
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
--
I
-----
S
----
L
----
D
--
G
HDI
R
-----
Q
----
L
N
P
V
--
W
-
L
---
R
S
-
K
I
G
T
V
S
Q
--
E
----
P
I
L
F
S
C
S
---
I
A
E
N
--
I
A
Y
G
-
A
D
D
-----
P
-----
S
S
-----
V
T
A
E
E
I
Q
R
V
A
E
V
-----------
A
N
A
V
A
F
I
R
N
FP
Q
G
F
N
T
V
V
G
E
K
-----
G
V
----
L
-
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
----
L
D
A
E
N
E
Y
L
V
Q
E
-
A
L
D
R
L
-
M
D
---
G
R
-
T
V
L
V
I
A
H
H
L
S
T
I
K
N
A
---------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
38.30
31%
11
- C1 -
4AYX
2
ABCBA_HUMAN
A:
[362-548]
-------------------------------
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
--
I
-----
S
----
L
----
D
--
G
HDI
R
-----
Q
----
L
N
P
V
--
W
-
L
---
R
S
-
K
I
G
T
V
S
Q
--
E
----
P
I
L
F
S
C
S
---
I
A
E
N
--
I
A
Y
G
-
A
D
D
-----
P
-----
S
S
-----
V
T
A
E
E
I
Q
R
V
A
E
V
-----------
A
N
A
V
A
F
I
R
N
FP
Q
G
F
N
T
V
V
G
E
K
-----
G
V
----
L
-
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
-
A
L
D
R
L
-
M
D
---
G
R
-
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
---------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
37.39
31%
13
- C1 -
4AYT
2
ABCBA_HUMAN
A:
[362-548]
-------------------------------
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
--
I
-----
S
----
L
----
D
--
G
HDI
R
-----
Q
----
L
N
P
V
--
W
-
L
---
R
S
-
K
I
G
T
V
S
Q
--
E
----
P
I
L
F
S
C
S
---
I
A
E
N
--
I
A
Y
G
-
A
D
D
-----
P
-----
S
S
-----
V
T
A
E
E
I
Q
R
V
A
E
V
-----------
A
N
A
V
A
F
I
R
N
FP
Q
G
F
N
T
VVGE
K
-----
G
V
----
L
-
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
-
A
L
D
R
L
-
M
D
---
G
R
-
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
---------------------------------------------------------------------------------------------------------------------------------