@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu34350: (2016-07-28 )
MIIALDTYLVLNSVIAGYQFLKDSYQFYDSGALLLTAVSLLLSYHVCAFLFNQYKQVWTYTGLGELIVLLKGITLSAAVTGVIQYAVYHTMFFRLLTACWVLQLLSIGGTRILSRVLNESIRKKRCASSRALIIGAGSGGTLMVRQLLSKDEPDIIPVAFIDDDQTKHKLEIMGLPVIGGKESIMPAVQKLKINYIIIAIPSLRTHELQVLYKECVRTGVSIKIMPHFDEMLLGTRTAGQIRDVKAEDLLGRKPVTLDTSEISNRIKGKTVLVTGAGGSIGSEICRQISAFQPKEIILLGHGENSIHSIYTELNGRFGKHIVFHTEIADVQDRDKMFTLMKKYEPHVVYHAAAHKHVPLMEHNPEEAVKNNIIGTKNVAEAADMSGTETFVLISSDKAVNPANVMGATKRFAEMIIMNLGKVSRTKFVAVRFGNVLGSRGSVIPIFKKQIEKGGPVTVTHPAMTRYFMTIPEASRLVIQAGALAKGRQIFVLDMGEPVKIVDLAKNLIHLSGYTTEQVPIEFTGIRPGEKMYEELLNKNEVHAEQIFPKIHIGKAVDGDWPVLMRFIEDFHELPEADLRARLFAAINTSEEMTAASVH
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250..------.....260.......270.......280......-.290........300.......310......-.320.......330..--.....340.......350.......360.........370.......380----........390.......--------------400..----------------.....410.....----..420.---....---...430.......------440-----------........450.-......-------.460-.......470.......480..---..-...490.....-....500........510.....-------------------..520..-.....530.......540........550....-..-.--560.......570...--.-...580.......590......---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
I
I
A
L
D
T
Y
L
V
L
N
S
V
I
A
G
Y
Q
F
L
K
D
S
Y
Q
F
YDSG
A
L
L
L
T
A
V
S
L
L
L
S
Y
H
V
C
A
F
L
F
N
Q
Y
K
Q
V
WTYT
G
L
G
E
L
I
V
L
L
KG
I
T
L
S
A
A
V
T
G
V
I
Q
Y
A
V
Y
H
T
M
F
F
R
L
L
T
A
C
W
V
L
Q
L
L
SIG
G
T
R
I
L
S
R
V
L
N
E
S
I
R
K
K
RCASS
R
A
L
I
I
GAGS
G
G
T
L
M
V
R
Q
L
LSKDEP
D
I
I
P
V
A
F
IDDDQT
K
H
K
L
E
I
M
GLPVIGG
K
E
S
I
M
P
A
V
Q
K
L
K
I
N
Y
I
I
I
AIPSLR
T
H
E
L
Q
V
L
Y
K
E
C
V
RTG
V
S
I
K
I
MPH
F
D
E
M
L
L
GTRTAG
Q
I
RDV
K
A
E
D
LLGRKP------
V
T
L
D
T
S
E
I
S
N
RIKG
K
T
V
L
V
TGAGG
S
I
G
S
E
I
C
R
Q
I
-SA-FQP
K
E
I
I
L
L
GHGE
N
S
I
H
S
I
Y
T
E
LNGRFG-
K
H
I
V
F
H
TEIAD
V
Q
D
R
D
--
K
M
F
T
L
M
K
KYEP
H
V
V
Y
H
AAAHKHVPLM--EH
N
P
E
E
A
V
K
NNIIGT
K
N
V
A
E
A-----ADMSG
T
E
T
F
V
L
I
SSDKAV--------------
N
P
A
N
V
----------------
M
G
A
T
K
R
F
A
E
M
I
I
M
----NLGK-V---S
R
T
K
---
F
V
A
V
R
F
G
N
V
LGSR------G
S
------------
V
I
P
I
F
K
K
QIE-K-GG
P
V
T
V
-------T
H
P
A
-
M
T
R
Y
F
M
TIPEA
S
R
L
V
I
QAGALA---KG-
R
Q
I
F
--
V
L
DMG-E
P
V
K
I
V
-
D
L
A
K
N
L
I
HLSGYTT
E
Q
-------------------
V
P
I
E
F
TG-IR
P
G
E
K
M
Y
E
E
L
LNKNE-V
H
A
E
Q
IF
P
K
I
HIGKAV-DG-
D
--
W
P
V
L
M
R
F
I
E
D
F
H
EL
P
E
--
A
-
D
L
R
A
R
L
F
AAINTSEEMTAASVH---
9
PsiBlast_PDB
88.51
36%
0
- C- -
4J2O
2
?
A:
[21-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
D
K
V
L
L
I
T
G
G
T
G
S
F
G
N
A
V
L
K
R
F
-
L
E
-
T
D
I
K
E
I
R
I
F
S
R
D
E
K
K
Q
D
D
M
R
K
K
Y
H
S
----
A
K
L
K
F
Y
--
I
G
D
V
R
D
Y
N
--
S
I
L
N
A
T
R
G
V
D
--
Y
I
Y
H
A
A
A
L
K
Q
V
P
S
C
--
E
F
H
P
M
E
A
V
K
T
N
V
L
G
T
E
N
V
L
E
A
-----
A
I
Q
N
H
V
K
R
V
V
C
L
S
T
D
K
A
V
--------------
Y
P
I
N
A
----------------
M
G
I
S
K
A
M
M
E
K
V
M
V
A
K
S
R
N
L
E
G
-
L
---
D
-
T
V
---
I
C
G
T
R
Y
G
N
V
M
A
S
R
------
G
S
------------
V
I
P
L
F
V
D
Q
I
R
-
Q
-
G
K
P
L
T
I
-------
T
D
P
N
-
M
T
R
F
M
M
T
L
E
D
A
V
D
L
V
L
Y
A
F
E
H
G
---
E
N
-
G
D
I
F
--
V
-
Q
K
A
-
P
A
A
T
I
A
-
V
L
A
E
A
L
K
Q
L
--
L
N
V
E
D
-------------------
H
P
I
S
I
M
G
-
T
R
H
G
E
K
A
F
E
A
L
L
S
R
E
E
M
V
H
A
-----------------------------------------------------------------
8
PsiBlast_PDB
83.57
35%
0
- C- -
3VVC
6
?
A:
[26-309]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
L
L
I
T
G
G
T
G
S
F
G
N
A
V
M
K
R
F
-
L
D
-
S
N
I
K
E
I
R
I
F
S
R
D
E
K
K
Q
D
D
I
R
K
K
Y
N
N
----
S
K
L
K
F
Y
--
I
G
D
V
R
D
S
Q
--
S
V
E
T
A
M
R
D
V
D
--
Y
V
F
H
A
A
A
L
K
Q
V
P
S
C
--
E
F
F
P
V
E
A
V
K
T
N
I
I
G
T
E
N
V
L
Q
S
-----
A
I
H
Q
N
V
K
K
V
I
C
L
S
T
D
E
A
A
--------------
Y
P
I
N
A
----------------
M
G
I
S
K
A
M
M
E
K
V
F
V
----
A
K
S
R
-
N
---
I
R
S
E
Q
T
L
I
C
G
T
R
Y
G
N
V
M
A
S
R
------
G
S
------------
V
I
P
L
F
I
D
K
I
K
-
A
-
G
E
P
L
T
I
-------
T
D
P
D
-
M
T
R
F
L
M
S
L
E
D
A
V
E
L
V
V
H
A
F
K
H
A
---
E
T
-
G
D
I
M
--
V
--
Q
K
-
A
P
S
S
T
V
G
D
L
A
T
A
L
L
E
L
--
F
E
A
D
N
-------------------
A
-
I
E
I
I
G
-
T
R
H
G
E
K
K
A
E
T
L
L
T
R
E
E
---------------------------------------------------------------------
6
PsiBlast_PDB
73.03
36%
-70
- C1 -
3W1V
7
?
A:
[26-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
L
L
I
T
G
G
T
G
S
F
G
N
A
V
M
K
R
F
-
L
D
-
S
N
I
K
E
I
R
I
F
S
R
D
E
K
K
Q
D
D
I
R
K
K
Y
N
N
----
S
K
L
K
F
Y
--
I
G
D
V
R
D
S
Q
--
S
V
E
T
A
M
R
D
V
D
--
Y
V
F
H
A
A
A
L
K
Q
V
P
S
C
--
E
F
F
P
V
E
A
V
K
T
N
I
I
G
T
E
N
V
L
Q
S
-----
A
I
H
Q
N
V
K
K
V
I
C
L
S
T
D
K
A
A
--------------
Y
P
I
N
A
----------------
M
G
I
S
K
A
M
M
E
K
V
F
V
----
A
K
S
R
-
N
---
I
R
S
E
Q
T
L
I
C
G
T
R
Y
G
N
V
M
A
S
R
------
G
S
------------
V
I
P
L
F
I
D
K
I
K
-
A
-
G
E
P
L
T
I
-------
T
D
P
D
-
M
T
R
F
L
M
S
L
E
D
A
V
E
L
V
V
H
A
F
K
H
A
---
E
T
-
G
D
I
M
--
V
--
Q
K
-
A
P
S
S
T
V
G
D
L
A
T
A
L
L
E
L
--
F
E
A
D
N
-------------------
A
-
I
E
I
I
G
-
T
R
H
G
E
K
K
A
E
T
L
L
T
R
E
E
---------------------------------------------------------------------
7
PsiBlast_PDB
72.32
36%
-69
- C1 -
4G5H
15
?
A:
[26-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
L
L
I
T
G
G
T
G
S
F
G
N
A
V
M
K
R
F
-
L
D
-
S
N
I
K
E
I
R
I
F
S
R
D
E
K
K
Q
D
D
I
R
K
K
Y
N
N
----
S
K
L
K
F
Y
--
I
G
D
V
R
D
S
Q
--
S
V
E
T
A
M
R
D
V
D
--
Y
V
F
H
A
A
A
L
K
Q
V
P
S
C
--
E
F
F
P
V
E
A
V
K
T
N
I
I
G
T
E
N
V
L
Q
S
-----
A
I
H
Q
N
V
K
K
V
I
C
L
S
T
D
K
A
A
--------------
Y
P
I
N
A
----------------
M
G
I
S
K
A
M
M
E
K
V
F
V
----
A
K
S
R
-
N
---
I
R
S
E
Q
T
L
I
C
G
T
R
Y
G
N
V
M
A
S
R
------
G
S
------------
V
I
P
L
F
I
D
K
I
K
-
A
-
G
E
P
L
T
I
-------
T
D
P
D
-
M
T
R
F
L
M
S
L
E
D
A
V
E
L
V
V
H
A
F
K
H
A
---
E
T
-
G
D
I
M
--
V
--
Q
K
-
A
P
S
S
T
V
G
D
L
A
T
A
L
L
E
L
--
F
E
A
D
N
-------------------
A
-
I
E
I
I
G
-
T
R
H
G
E
K
K
A
E
T
L
L
T
R
E
E
---------------------------------------------------------------------
26
PsiBlast_CBE
71.43
36%
-66
- C1 -
3W1V
7
?
B:
[26-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
L
L
I
T
G
G
T
G
S
F
G
N
A
V
M
K
R
F
-
L
D
-
S
N
I
K
E
I
R
I
F
S
R
D
E
K
K
Q
D
D
I
R
K
K
Y
N
N
----
S
K
L
K
F
Y
--
I
G
D
V
R
D
S
Q
--
S
V
E
T
A
M
R
D
V
D
--
Y
V
F
H
A
A
A
L
K
Q
V
P
S
C
--
E
F
F
P
V
E
A
V
K
T
N
I
I
G
T
E
N
V
L
Q
S
-----
A
I
H
Q
N
V
K
K
V
I
C
L
S
T
D
K
A
A
--------------
Y
P
I
N
A
----------------
M
G
I
S
K
A
M
M
E
K
V
F
V
----
A
K
S
R
-
N
---
I
R
S
E
QTL
I
C
G
T
R
Y
G
N
V
M
A
S
R
------
G
S
------------
V
I
P
L
F
I
D
K
I
K
-
A
-
G
E
P
L
T
I
-------
T
D
P
D
-
M
T
R
F
L
M
S
L
E
D
A
V
E
L
V
V
H
A
F
K
H
A
---
E
T
-
G
D
I
M
--
V
--
Q
K
-
A
P
S
S
T
V
G
D
L
A
T
A
L
L
E
L
--
F
E
A
D
N
-------------------
A
-
I
E
I
I
G
-
T
R
H
G
E
K
K
A
E
T
L
L
T
R
E
E
---------------------------------------------------------------------
46
Fugue
71.02
31%
-6
- C1 -
2GN4
3
PSEB_HELPY
A:
[16-344]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
N
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
-
L
D
T
T
N
A
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
E
F
N
------
D
P
R
M
R
F
F
I
G
D
V
R
D
L
E
--
R
L
N
Y
A
L
E
G
--
V
D
I
C
I
H
A
A
A
L
K
H
V
P
I
A
--
E
Y
N
P
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
A
-----
C
L
K
N
A
I
S
Q
V
I
A
L
S
T
D
K
A
A
--------------
N
P
I
N
L
----------------
Y
G
A
T
K
L
C
S
D
K
L
F
V
----
S
A
N
N
-
F
KGS
S
Q
T
Q
---
F
S
V
V
R
Y
G
N
V
V
G
S
R
------
G
S
------------
V
V
P
F
F
K
K
L
V
Q
-
N
K
A
S
E
I
P
I
-------
T
D
I
R
-
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
---
H
G
-
G
E
I
F
--
V
P
K
I
--
P
S
M
K
M
T
-
D
L
A
K
A
L
A
-------
P
N
-------------------
T
P
T
K
I
I
G
-
I
R
P
G
E
K
L
H
E
V
M
I
P
K
D
E
-
S
H
L
A
L
E
F
E
D
F
F
I
I
Q
P
T
-
I
S
-
F
--
Q
T
P
K
D
Y
T
L
T
K
L
H
E
K
G
Q
--
K
-
V
A
P
D
F
E
Y
S
S
H
N
N
N
Q
W
L
E
P
D
D
L
L
K
L
L
4
PsiBlast_PDB
66.64
34%
-24
- C1 -
2GN9
2
PSEB_HELPY
A:
[17-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
T
-
T
N
A
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
E
F
N
D
P
R
M
-
R
F
F
-----
I
G
D
V
R
D
L
E
--
R
L
N
Y
A
L
E
G
V
D
--
I
C
I
H
A
A
A
L
K
H
V
P
I
A
--
E
Y
N
P
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
A
-----
C
L
K
N
A
I
S
Q
V
I
A
L
S
T
D
K
A
A
--------------
N
P
I
N
L
----------------
Y
G
A
T
K
L
C
S
D
K
L
F
V
S
A
N-
N
F
K
G
-
S
---
S
Q
T
Q
---
F
S
V
V
R
Y
G
N
V
V
G
S
R
------
G
S
------------
V
V
P
F
F
K
K
L
V
Q
N
K
-
A
S
E
I
P
I
-------
T
D
I
R
-
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
---
H
G
-
G
E
I
F
--
V
P
K
I
P
-
S
-
M
K
M
T
-
D
L
A
K
A
L
-------
A
P
N
-------------------
T
P
T
K
I
I
G
-
I
R
P
G
E
K
L
H
E
V
M
I
P
K
D
E
-
S
H
------------------------------------------------------------------
23
PsiBlast_CBE
66.35
34%
-26
- C1 -
2GN8
3
PSEB_HELPY
B:
[17-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
T
-
T
N
A
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
E
F
N
D
P
R
M
-
R
F
F
-----
I
G
D
V
R
D
L
E
--
R
L
N
Y
A
L
E
G
V
D
--
I
C
I
H
A
A
A
L
K
H
V
P
I
A
--
E
Y
N
P
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
A
-----
C
L
K
N
A
I
S
Q
V
I
A
L
S
T
D
K
A
A
--------------
N
P
I
N
L
----------------
Y
G
A
T
K
L
C
S
D
K
L
F
V
S
AN-
N
F
K
G
-
S
---
S
Q
T
Q
---
F
S
V
V
R
Y
G
N
V
V
G
S
R
------
G
S
------------
V
V
P
F
F
K
K
L
V
Q
N
K
-
A
S
E
I
P
I
-------
T
D
I
R
-
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
---
H
G
-
G
E
I
F
--
V
P
K
I
P
-
S
-
M
K
M
T
-
D
L
A
K
A
L
-------
A
P
N
-------------------
T
P
T
K
I
I
G
-
I
R
P
G
E
K
L
H
E
V
M
I
P
K
D
E
-
S
H
------------------------------------------------------------------
5
PsiBlast_PDB
65.47
34%
-21
- C1 -
2GNA
2
PSEB_HELPY
A:
[17-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
T
-
T
N
A
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
E
F
N
D
P
R
M
-
R
F
F
-----
I
G
D
V
R
D
L
E
--
R
L
N
Y
A
L
E
G
V
D
--
I
C
I
H
A
A
A
L
K
H
V
P
I
A
--
E
Y
N
P
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
A
-----
C
L
K
N
A
I
S
Q
V
I
A
L
S
T
D
K
A
A
--------------
N
P
I
N
L
----------------
Y
G
A
T
K
L
C
S
D
K
L
F
V
S
AN-
N
F
K
G
-
S
---
S
Q
T
Q
---
F
S
V
V
R
Y
G
N
V
V
G
S
R
------
G
S
------------
V
V
P
F
F
K
K
L
V
Q
N
K
-
A
S
E
I
P
I
-------
T
D
I
R
-
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
---
H
G
-
G
E
I
F
--
V
P
K
I
P
-
S
-
M
K
M
T
-
D
L
A
K
A
L
-------
A
P
N
-------------------
T
P
T
K
I
I
G
-
I
R
P
G
E
K
L
H
E
V
M
I
P
K
D
E
-
S
H
------------------------------------------------------------------
1
PsiBlast_PDB
65.22
34%
-17
- C1 -
2GN4
3
PSEB_HELPY
A:
[17-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
T
-
T
N
A
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
E
F
N
D
P
R
M
-
R
F
F
-----
I
G
D
V
R
D
L
E
--
R
L
N
Y
A
L
E
G
V
D
--
I
C
I
H
A
A
A
L
K
H
V
P
I
A
--
E
Y
N
P
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
A
-----
C
L
K
N
A
I
S
Q
V
I
A
L
S
T
D
K
A
A
--------------
N
P
I
N
L
----------------
Y
G
A
T
K
L
C
S
D
K
L
F
V
S
A
N-
N
F
K
G
-
S
---
S
Q
T
Q
---
F
S
V
V
R
Y
G
N
V
V
G
S
R
------
G
S
------------
V
V
P
F
F
K
K
L
V
Q
N
K
-
A
S
E
I
P
I
-------
T
D
I
R
-
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
---
H
G
-
G
E
I
F
--
V
P
K
I
P
-
S
-
M
K
M
T
-
D
L
A
K
A
L
-------
A
P
N
-------------------
T
P
T
K
I
I
G
-
I
R
P
G
E
K
L
H
E
V
M
I
P
K
D
E
-
S
H
------------------------------------------------------------------
25
PsiBlast_CBE
65.15
34%
-21
- C1 -
2GN4
4
PSEB_HELPY
B:
[18-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
T
-
T
N
A
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
E
F
N
D
P
R
M
-
R
F
F
-----
I
G
D
V
R
D
L
E
--
R
L
N
Y
A
L
E
G
V
D
--
I
C
I
H
A
A
A
L
K
H
V
P
I
A
--
E
Y
N
P
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
A
-----
C
L
K
N
A
I
S
Q
V
I
A
L
S
T
D
K
A
A
--------------
N
P
I
N
L
----------------
Y
G
A
T
K
L
C
S
D
K
L
F
V
S
A
N-
N
F
K
G
-
S
---
S
Q
T
Q
---
F
S
V
V
R
Y
G
N
V
V
G
S
R
------
G
S
------------
V
V
P
F
F
K
K
L
V
Q
N
K
-
A
S
E
I
P
I
-------
T
D
I
R
-
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
---
H
G
-
G
E
I
F
--
V
P
K
I
P
-
S
-
M
K
M
T
-
D
L
A
K
A
L
-------
A
P
N
-------------------
T
P
T
K
I
I
G
-
I
R
P
G
E
K
L
H
E
V
M
I
P
K
D
E
-
S
H
------------------------------------------------------------------
2
PsiBlast_PDB
65.01
34%
-22
- C1 -
2GN6
2
PSEB_HELPY
A:
[17-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
T
-
T
N
A
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
E
F
N
D
P
R
M
-
R
F
F
-----
I
G
D
V
R
D
L
E
--
R
L
N
Y
A
L
E
G
V
D
--
I
C
I
H
A
A
A
L
K
H
V
P
I
A
--
E
Y
N
P
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
A
-----
C
L
K
N
A
I
S
Q
V
I
A
L
S
T
D
K
A
A
--------------
N
P
I
N
L
----------------
Y
G
A
T
K
L
C
S
D
K
L
F
V
S
AN-
N
F
K
G
-
S
---
S
Q
T
Q
---
F
S
V
V
R
Y
G
N
V
V
G
S
R
------
G
S
------------
V
V
P
F
F
K
K
L
V
Q
N
K
-
A
S
E
I
P
I
-------
T
D
I
R
-
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
---
H
G
-
G
E
I
F
--
V
P
K
I
P
-
S
-
M
K
M
T
-
D
L
A
K
A
L
-------
A
P
N
-------------------
T
P
T
K
I
I
G
-
I
R
P
G
E
K
L
H
E
V
M
I
P
K
D
E
-
S
H
------------------------------------------------------------------
3
PsiBlast_PDB
64.94
34%
-24
- C1 -
2GN8
3
PSEB_HELPY
A:
[18-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
T
-
T
N
A
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
E
F
N
D
P
R
M
-
R
F
F
-----
I
G
D
V
R
D
L
E
--
R
L
N
Y
A
L
E
G
V
D
--
I
C
I
H
A
A
A
L
K
H
V
P
I
A
--
E
Y
N
P
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
A
-----
C
L
K
N
A
I
S
Q
V
I
A
L
S
T
D
K
A
A
--------------
N
P
I
N
L
----------------
Y
G
A
T
K
L
C
S
D
K
L
F
V
S
AN-
N
F
K
G
-
S
---
S
Q
T
Q
---
F
S
V
V
R
Y
G
N
V
V
G
S
R
------
G
S
------------
V
V
P
F
F
K
K
L
V
Q
N
K
-
A
S
E
I
P
I
-------
T
D
I
R
-
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
---
H
G
-
G
E
I
F
--
V
P
K
I
P
-
S
-
M
K
M
T
-
D
L
A
K
A
L
-------
A
P
N
-------------------
T
P
T
K
I
I
G
-
I
R
P
G
E
K
L
H
E
V
M
I
P
K
D
E
-
S
H
------------------------------------------------------------------
21
PsiBlast_CBE
64.82
34%
-21
- C1 -
2GNA
3
PSEB_HELPY
B:
[18-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
T
-
T
N
A
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
E
F
N
D
P
R
M
-
R
F
F
-----
I
G
D
V
R
D
L
E
--
R
L
N
Y
A
L
E
G
V
D
--
I
C
I
H
A
A
A
L
K
H
V
P
I
A
--
E
Y
N
P
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
A
-----
C
L
K
N
A
I
S
Q
V
I
A
L
S
T
D
K
A
A
--------------
N
P
I
N
L
----------------
Y
G
A
T
K
L
C
S
D
K
L
F
V
S
AN-
N
F
K
G
-
S
---
S
Q
T
Q
---
F
S
V
V
R
Y
G
N
V
V
G
S
R
------
G
S
------------
V
V
P
F
F
K
K
L
V
Q
N
K
-
A
S
E
I
P
I
-------
T
D
I
R
-
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
---
H
G
-
G
E
I
F
--
V
P
K
I
P
-
S
-
M
K
M
T
-
D
L
A
K
A
L
-------
A
P
N
-------------------
T
P
T
K
I
I
G
-
I
R
P
G
E
K
L
H
E
V
M
I
P
K
D
E
-
S
H
------------------------------------------------------------------
24
PsiBlast_CBE
64.73
34%
-23
- C1 -
2GN6
3
PSEB_HELPY
B:
[18-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
T
-
T
N
A
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
E
F
N
D
P
R
M
-
R
F
F
-----
I
G
D
V
R
D
L
E
--
R
L
N
Y
A
L
E
G
V
D
--
I
C
I
H
A
A
A
L
K
H
V
P
I
A
--
E
Y
N
P
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
A
-----
C
L
K
N
A
I
S
Q
V
I
A
L
S
T
D
K
A
A
--------------
N
P
I
N
L
----------------
Y
G
A
T
K
L
C
S
D
K
L
F
V
S
AN-
N
F
K
G
-
S
---
S
Q
T
Q
---
F
S
V
V
R
Y
G
N
V
V
G
S
R
------
G
S
------------
V
V
P
F
F
K
K
L
V
Q
N
K
-
A
S
E
I
P
I
-------
T
D
I
R
-
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
---
H
G
-
G
E
I
F
--
V
P
K
I
P
-
S
-
M
K
M
T
-
D
L
A
K
A
L
-------
A
P
N
-------------------
T
P
T
K
I
I
G
-
I
R
P
G
E
K
L
H
E
V
M
I
P
K
D
E
-
S
H
------------------------------------------------------------------
64
HHSearch
63.54
25%
6
- C1 -
3PVZ
7
?
A:
[6-386]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
L
S
L
I
G
R
D
T
ELF
H
Q
D
I
N
A
N
E
K
E
L
Q
S
V
V
S
Q
S
R
F
L
V
L
G
G
A
G
S
I
G
Q
A
V
T
K
E
I
-
F
K
-
R
N
P
Q
K
L
H
V
V
D
I
S
E
N
N
M
V
E
L
V
R
D
I
R
S
S
F
G
Y
I
N
G
D
F
Q
T
F
A
L
D
I
G
S
I
E
Y
D
A
F
I
K
A
D
G
--
Q
Y
D
Y
V
L
N
L
S
A
L
K
H
V
R
S
E
KD
P
F
T
L
M
R
M
I
D
V
N
V
F
N
T
D
K
T
I
Q
Q
-----
S
I
D
A
G
A
K
K
Y
F
C
V
S
T
D
K
A
A
--------------
N
P
V
N
M
----------------
M
G
A
S
K
R
I
M
E
M
F
L
M
----
R
K
S
------
E
E
I
A
---
I
S
T
A
R
F
A
N
V
A
F
S
D
------
G
S
------------
L
L
H
G
F
N
Q
R
I
Q
-
K
-
N
Q
P
I
-
V
-------
A
P
N
D
-
I
K
R
Y
F
V
T
P
Q
E
S
G
E
L
C
L
M
S
C
I
F
G
---
E
N
-
R
D
I
F
F
P
K
L
S
E
A
L
H
L
I
S
F
A
-
D
I
A
V
K
Y
L
K
Q
L
G
Y
E
P
H
L
C
ES
E
D
E
A
R
E
L
A
K
TLPAQG
K
W
P
C
L
F
T
S
S---------
E
F
F
T
D
K
E
-
T
L
D
M
A
R
F
D
N
L
G
I
I
K
N
D
S
L
Y
Q
Q
E
L
L
E
L
F
E
Q
K
I
G
Q
M
K
T
D
R
Q
WT
K
E
E
I
V
Q
L
F
F
I
M
I
P
D
F
------------
22
PsiBlast_CBE
62.78
34%
-24
- C1 -
2GN9
4
PSEB_HELPY
B:
[18-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
D
N
Q
T
I
L
I
T
G
G
T
G
S
F
G
K
C
F
V
R
K
V
L
D
T
-
T
N
A
K
K
I
I
V
Y
S
R
D
E
L
K
Q
S
E
M
A
M
E
F
N
D
P
R
M
-
R
F
F
-----
I
G
D
V
R
D
L
E
--
R
L
N
Y
A
L
E
G
V
D
--
I
C
I
H
A
A
A
L
K
H
V
P
I
A
--
E
Y
N
P
L
E
C
I
K
T
N
I
M
G
A
S
N
V
I
N
A
-----
C
L
K
N
A
I
S
Q
V
I
A
L
S
T
D
K
A
A
--------------
N
P
I
N
L
----------------
Y
G
A
T
K
L
C
S
D
K
L
F
V
S
A
N-
N
F
K
G
-
S
---
S
Q
T
Q
---
F
S
V
V
R
Y
G
N
V
V
G
S
R
------
G
S
------------
V
V
P
F
F
K
K
L
V
Q
N
K
-
A
S
E
I
P
I
-------
T
D
I
R
-
M
T
R
F
W
I
T
L
D
E
G
V
S
F
V
L
K
S
L
K
R
M
---
H
G
-
G
E
I
F
--
V
P
K
I
P
-
S
-
M
K
M
T
-
D
L
A
K
A
L
-------
A
P
N
-------------------
T
P
T
K
I
I
G
-
I
R
P
G
E
K
L
H
E
V
M
I
P
K
D
E
-
S
H
------------------------------------------------------------------
66
HHSearch
58.85
22%
-66
- C1 -
4WOK
3
?
A:
[11-331]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
N
V
L
V
V
G
G
A
G
F
I
G
S
H
T
A
K
L
L
-
A
G
-
Q
G
Y
-
A
P
V
V
Y
D
N
L
S
T
G
H
Q
S
A
-----------
V
R
W
G
D
F
V
E
G
D
I
L
D
Q
A
--
R
L
V
E
T
M
E
K
Y
A
P
V
A
V
I
H
F
A
A
S
A
Y
V
G
E
S
--
V
E
D
P
A
K
Y
Y
R
N
N
V
G
G
T
Q
S
L
L
D
A
-----
C
R
L
T
R
T
Q
N
V
I
F
S
S
S
C
A
T
Y
GVPSRLPIGEG
E
A
Q
N
P
I
N
P
----------------
Y
G
R
T
K
L
I
A
E
H
M
L
A
----
D
Y
A
V
-
A
---
Y
G
L
R
---
Y
V
A
L
R
Y
F
N
A
S
G
A
D
------
I
D
GE
L
G
E
K
H
DPETH
L
I
P
R
A
M
M
A
A
A
-
G
R
L
D
V
L
E
V
Y
G
DDYET
P
D
G
T
-
C
I
R
D
Y
I
H
V
T
D
L
A
R
A
H
V
L
A
V
E
H
L
K
E
A
G
G
-
N
L
A
V
--
N
L
G
T
G
-
R
G
T
S
I
R
-
E
I
V
Q
S
I
G
R
L
T
G
R
S
V
----------------------
P
V
A
M
R
A
---------------
R
--
R
A
----
G
----
D
P
P
A
L
-
Y
A
-
D
--
P
A
L
A
A
E
K
L
G
-
F
H
T
V
Y
---
S
-
D
L
D
T
I
I
R
T
A
A
P
H
F
G
-----------
13
PsiBlast_PDB
57.64
22%
-57
- C1 -
4ZRN
2
?
A:
[5-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
L
V
T
G
G
A
G
F
I
G
S
H
V
V
D
K
L
----------
I
E
N
G
Y
G
V
I
V
V
D
N
L
S
S
G
K
V
E
N
L
N
-
R
N
A
L
F
Y
E
Q
--
S
I
E
D
E
E
--
M
M
E
R
I
F
S
L
H
R
P
E
Y
V
F
H
L
A
A
Q
A
S
V
A
I
S
--
V
R
E
P
A
R
D
A
K
T
N
I
I
G
S
L
V
L
L
E
K
-----
S
I
K
Y
G
V
K
K
F
I
F
S
S
T
G
G
A
I
--------------
Y
G
E
N
V
KVFPTPETE
I
P
H
P
IS
P
Y
G
I
A
K
Y
S
T
E
M
Y
L
E
----
F
F
A
R
-
E
---
Y
G
L
K
---
Y
T
V
L
R
Y
A
N
V
Y
G
P
R
QDPYGE
A
G
------------
V
V
A
I
F
T
E
R
M
L
-
R
-
G
E
E
V
H
I
-------
F
G
D
G
E
Y
V
R
D
Y
V
Y
V
D
D
V
V
R
A
N
L
L
--
A
M
E
---
K
G
D
N
E
V
F
--
N
I
G
T
G
-
R
G
T
T
V
N
-
Q
L
F
K
L
L
K
E
I
T
G
Y
D
K
E
P
-------------------
V
--------------------------------------------------------------------------------------------
10
PsiBlast_PDB
57.10
29%
-23
- C1 -
4TQG
1
?
A:
[2-290]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
N
D
K
T
I
M
I
F
G
G
S
G
S
L
G
N
---
R
L
I
-
E
T
-
Y
I
N
N
N
I
I
V
N
Y
S
R
D
E
S
K
H
-
W
S
M
E
L
K
Y
K
S
D
-
K
---
L
K
N
I
I
G
D
I
R
D
F
E
--
K
V
Q
Q
S
I
M
R
I
N
P
D
I
I
I
I
A
A
A
L
K
H
I
D
R
C
--
E
Y
E
I
N
E
C
L
D
T
N
I
K
G
L
Q
N
V
L
K
V
T
E
I
NR
S
N
L
S
N
L
K
A
V
C
F
V
S
T
D
K
A
C
--------------
S
P
V
N
S
----------------
Y
G
M
S
K
A
I
C
E
T
L
V
V
----
E
K
S
K
Y
I
---
K
D
I
K
---
Y
V
C
V
R
Y
G
N
V
L
N
--------------------------------------
F
T
L
-------
T
H
T
S
-
M
T
R
F
I
M
T
L
D
D
S
V
K
L
I
E
Y
A
I
I
N
G
---
N
S
-
G
E
I
V
--
I
P
K
L
N
-
S
M
------
Y
I
K
D
M
I
E
L
F
A
D
K
Y
----------------------
P
I
V
I
T
G
-
L
R
S
G
E
R
M
Y
E
S
L
I
--
N
D
-
T
Q
S
M
K
T
V
P
K
---------
G
-
D
--
Y
---------
Y
H
I
L
P
T
--
Y
-
D
------------------------