@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu34440: (2016-07-28 )
MKQNKRKHLQTLFETLGEKHQFNGTVLAAEGGDILYHHSFGYAEMTEKRPLKTNSLFELASLSKPFTALGIILLEEKGILGYEDKVDRWLPGFPYQGVTIRHLLNHTSGLPDYMGWFFANWDSHKIAVNQDIVDMLMNEGLSGYFEPNEGWMYSNTGYVLLAVIIEKASGMSYADFIKTSIFLPAGMNETRVYNRRLSPERIDHYAYGYVYDVHSETYVLPDELEETNYVVYLDGIQGDGTVNSVTSDLFRFDQALYQDDFISKASKESAFSPVRLNNGETIDYGFGWVLQNSPEKGRIVSHSGGWPGYSTMMIRYIDHRKTLIYLSNKEEDTEYEQAILKAAEHILFGQPYDVPERPADKKKKAIDTAIYSRYVGSYLLQDGTAAQVTTENERLYLEIAGQLRLELFPSSETRFFLRALSVEVEFTLGEDAAKSFILYEDGSEEEAVRTK
Atome Classification :
(20 SA)
.........10.....-...20...-....-.30........40........50........60........70........80........--90.-...---....100.......110--------...----.....----120--.--.-------.--......130....-...140........150.......160.......170.......180.......190.......200.......210.......220.-----.---.-..---..230--......-.240.......250-------.......--260.......270......---.280.---....-..290.-.-.....300.......310.......320.......330......-.-340.......350...------.---------------.---------------------.----.-------360.----------------.......370.......380-.-...-...390.......400----.---...------...410.......------420-------..----.......430..-.....440.......450-------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKQ
N
K
R
K
H
L
Q
T
L
F
E
T
L-GEKHQFN
G
-
T
V
L
A-AEGG
D
I
L
Y
H
HSFGY
A
E
M
TEKRPLKTN
S
L
F
E
L
A
SLSK
P
F
T
A
L
G
I
I
L
L
EEKGILGYE
D
K
V
D
RW--LPG-FPY---Q
G
V
T
I
R
H
L
L
N
HTSG
L
P
---------
D
Y
M
----
G
W
F
FA----N----W--D-------S--
H
K
I
AV
N
Q
D
I
V
D
M
L
-
M
NEG-LS
G
Y
FEPNE
G
W
M
YSNTG
Y
V
L
L
A
V
I
I
E
KASGM
S
Y
A
D
F
I
K
T
S
I
F
LPAGMNE
T
R
V
YNRRL
S
P
E
R
I
D
H
YA
Y
G
Y
V
Y
D
VHS
E
T
Y
VLPDE-----L---E-ET---
N
Y
V
V
Y
--
L
DGIQG-DG
T
V
N
S
V
T
S
D
L
F
R
F
-------
D
Q
A
L
Y
Q
D
--
D
F
I
S
KASKESAFS
P
V
RLNN---G
E
T
I
D
---
Y
G
F
G
-
W
V
LQNS-P-EKG
R
I
VSHSGGWPG
Y
S
T
M
M
I
R
Y
IDHR
K
T
L
I
Y
L
SNKEE
D
T
E
Y
E
Q
A
-
I
-
L
K
A
A
E
H
I
LFGQPYDVP------E---------------R---------------------P----A-------
D
K
-
K
----------------
K
K
A
I
D
T
A
I
Y
S
R
Y
V
G
S
Y
L
LQD-G-TA
A
-
Q
V
TTEN
E
R
L
Y
L
E
I
A
G
Q
----
L
---
R
L
E
------
L
FPSSET
R
F
F
L
R
A
------
L
---------
S
V
----
E
V
E
F
T
LGE
D
A
A
K
-
S
F
I
L
YEDGSEEEAVRTK--------------------------------------------------------------------------------
36
HHSearch
83.91
24%
-5
- C2 -
2QMI
-
?
A:
[3-435]
-----
V
G
K
L
E
S
F
I
V
E
K
M
A
E
R
K
V
P
G
I
-
S
I
S
I
-
I
K
D
G
D
V
V
Y
A
K
G
F
G
Y
R
N
V
E
A
R
L
P
S
T
P
E
T
I
Y
G
I
G
S
I
T
K
S
F
T
A
L
A
I
M
K
L
V
E
E
G
G
L
S
L
D
D
P
V
E
K
F
--
V
N
I
-
K
L
R
PFG
E
P
V
T
V
H
H
L
L
T
H
S
S
G
I
P
---------
S
L
G
----
Y
A
E
-
A
----
F
----
I
--
D
G
M
V
GGDN
W
--
L
P
V
S
T
P
E
E
T
I
A
F
A
-
R
D
M
E
-
K
W
A
V
A
K
P
G
E
R
F
F
Y
L
N
T
G
Y
V
L
L
G
K
I
I
E
K
V
S
G
V
S
Y
E
E
Y
I
K
K
K
I
L
E
P
L
G
M
N
R
S
Y
F
F
K
E
E
V
E
--
K
D
K
D
V
A
M
G
Y
I
L
D
K
E
G
R
L
V
---------------------
P
Q
P
-
F
--
P
Y
G
I
T
A
-
D
G
G
L
L
S
S
V
L
D
L
A
K
Y
-------
L
K
M
Y
I
E
R
DE
S
I
V
S
K
E
Y
I
E
K
M
E
T
S
Y
I
K
V
P
WEI
F
G
G
E
G
---
Y
G
Y
G
-
L
I
I
Y
P
N
F
L
-
G
E
-
K
L
V
G
H
S
G
S
V
G
M
Y
T
G
Y
I
G
Y
I
P
E
K
K
I
G
V
A
V
L
E
N
S
S
G
Y
P
P
S
-
Y
I
---
A
M
Y
A
L
A
L
L
L
G
K
N
P
E
K
E
------------------------------------------------------------
L
----------------
P
F
I
Y
R
E
R
I
L
K
K
V
E
G
R
Y
M
G
Y
K
-
G
T
I
K
F
-
E
V
K
V
D
G
D
V
V
Y
L
R
A
L
G
R
----
A
F
T
Y
T
I
P
------
L
F
P
E
V
L
E
E
D
F
I
K
C
Y
T
L
S
NG
R
---------
K
M
----
Y
A
E
F
Y
I
K
D
-
N
K
V
--------------------------------------------------------------------------------------------------
27
Fugue
79.72
23%
8
- C2 -
2QMI
-
?
A:
[1-447]
---
M
D
V
G
K
L
E
S
F
I
V
E
K
-
M
A
E
R
K
V
P
G
I
S
I
S
I
-
I
K
D
G
D
V
V
Y
A
K
G
F
G
Y
R
N
V
E
A
R
L
P
S
T
P
E
T
I
Y
G
I
G
S
I
T
K
S
F
T
A
L
A
I
M
K
L
V
E
E
G
G
L
S
L
D
D
P
V
E
K
F
--
V
N
I
-
K
L
R
PFG
E
P
V
T
V
H
H
L
L
T
H
S
S
G
I
P
---------
S
L
G
----
Y
A
E
A
F
----
I
----
D
--
G
M
V
GGDN-
W
--
L
P
V
S
T
P
E
E
T
I
A
F
A
-
R
D
M
E
-
K
W
A
V
A
K
P
G
E
R
F
F
Y
L
N
T
G
Y
V
L
L
G
K
I
I
E
K
V
S
G
V
S
Y
E
E
Y
I
K
K
K
I
L
E
P
L
G
M
N
R
S
Y
F
F
K
E
E
V
E
K
D
--
K
D
V
A
M
G
Y
I
L
D
K
E
G
R
L
V
P
Q
P
----------------------
F
--
P
Y
G
I
T
A
-
D
G
G
L
L
S
S
V
L
D
L
A
K
Y
-------
L
K
M
Y
I
E
R
DE
S
I
V
S
K
E
Y
I
E
K
M
E
T
S
Y
I
K
V
P
---
W
E
I
F
G
G
E
G
Y
G
Y
G
-
L
I
I
Y
P
N
-
F
-
L
G
E
K
L
V
G
H
S
G
S
V
G
M
Y
T
G
Y
I
G
Y
I
P
E
K
K
I
G
V
A
V
L
E
N
S
S
-
G
Y
P
P
S
Y
I
-
A
-
M
Y
A
L
A
L
L
L
-------
G
------
K
---------------
N
---------------------
P
----
E
-------
K
E
-
L
----------------
P
F
I
Y
R
E
R
I
L
K
K
V
E
G
R
Y
M
G
Y
K
-
G
T
I
K
F
-
E
V
K
V
D
G
D
V
V
Y
L
R
A
L
G
R
A
F
T
-
Y
---
T
I
P
------
L
F
P
E
V
L
E
E
D
F
I
K
C
------
Y
---------
T
L
S
NG
R
K
M
Y
A
E
F
Y
I
K
D
N
K
-
V
D
L
I
F
E
---
R
Y
R
L
I
K
S
---------------------------------------------------------------------------------
1
PsiBlast_PDB
73.15
26%
7
- C2 -
2QMI
-
?
A:
[10-418]
-----------
I
V
E
K
M
-
A
E
R
K
V
P
G
I
-
S
I
S
I
-
I
K
D
G
D
V
V
Y
A
K
G
F
G
Y
R
N
V
E
A
R
L
P
S
T
P
E
T
I
Y
G
I
G
S
I
T
K
S
F
T
A
L
A
I
M
K
L
V
E
E
G
G
L
S
L
D
D
P
V
E
K
F
VN
I
K
L
-
R
P
F
G--
E
P
V
T
V
H
H
L
L
T
H
S
S
G
I
P
SLG
Y
A
E
A
F
I
D
G
M
V
GGD
N
W
L
P
V
----
S
----
T
--
P
-------
E
--
E
T
I
A
F
A
R
D
M
E
K
W
A
-
V
A
K
--------
P
G
E
R
F
F
Y
L
N
T
G
Y
V
L
L
G
K
I
I
E
K
V
S
G
V
S
Y
E
E
Y
I
K
K
K
I
L
E
P
L
G
M
N
R
S
Y
F
F
K
E
E
V
--
E
K
D
K
D
V
A
M
G
Y
I
L
D
--
K
E
G
R
L
V
P
Q
P
-----
F
---
P
-
Y
-------------
G
I
T
A
-
D
G
G
L
L
S
S
V
L
D
L
A
K
Y
L
K
M
Y
I
E
R
D
E
S
I
V
S
K
--
E
Y
I
E
K
M
E
T
S
Y
I
K
V
P
W
E
I
F
G
---
G
E
--
G
---
Y
G
Y
G
-
L
I
I
Y
P
N
-
F
-
L
G
E
K
L
V
G
H
S
G
S
V
-
G
M
Y
T
G
Y
I
G
Y
I
P
E
K
K
--
I
G
V
A
V
L
E
N
S
S
G
Y
P
P
S
Y
I
-
A
M
Y
A
L
A
L
L
L
G
K
---------------------------
N
---------------------
P
----
E
-------
K
E
-
L
----------------
P
F
I
Y
R
E
R
I
L
K
K
V
E
G
R
Y
M
G
Y
K
-
G
-
T
I
K
F
E
V
K
V
D
G
D
V
V
Y
L
R
A
L
G
R
----
A
F
T
Y
T
I
P
------
L
F
P
E
V
L
E
E
D
F
I
K
C
------
Y
---------
T
L
------------------------------------------------------------------------------------------------------------------
49
HHSearch
72.87
27%
-18
- C2 -
2DRW
4
?
A:
[2-338]
--
S
D
L
N
N
A
I
Q
G
I
L
D
D
H
-
V
A
R
G
V
V
G
V
-
S
L
A
L
-
C
L
P
G
E
E
T
S
L
Y
Q
S
G
Y
A
D
K
F
N
K
M
P
M
T
G
D
H
L
F
R
I
A
S
C
T
K
S
F
I
A
T
G
L
H
L
L
V
Q
D
G
T
V
D
L
D
E
P
I
T
R
W
--
F
P
D
-
L
P
K
A--
A
Q
M
P
V
R
I
L
L
N
H
R
S
G
L
P
---------
D
F
E
----
T
S
M
-
P
----
M
-------
I
-------
S
--
D
K
S
W
T
A
Q
E
I
V
D
F
S
---
F
R
-
H
G
V
Q
K
E
P
W
H
G
M
E
Y
S
N
T
G
Y
V
L
A
G
M
I
I
A
H
E
T
G
K
P
Y
S
D
H
L
R
S
R
I
F
A
P
L
G
M
K
D
T
W
V
G
T
H
E
T
F
--
P
I
E
R
E
A
R
G
Y
M
H
A
A
A
D
D
E
N
P
Q
W
D
V
-----
S
GAG
D
P
V
D
GVW
D
S
T
E
W
FP
L
S
G
A
N
A
-
A
G
D
M
V
S
T
P
R
D
I
V
K
F
-------
L
N
A
L
F
D
G
--
R
I
L
D
Q
K
R
L
W
E
M
K
D
N
I
K
P
A
F
F
P
G
S
N
T
V
A
---
N
G
H
G
-
L
L
L
M
R
Y
-
G
-
S
S
-
E
L
K
G
H
L
G
Q
I
P
G
H
T
S
I
M
G
R
D
E
E
T
G
A
A
L
M
L
I
Q
N
S
G
A
G
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
70.58
25%
-0
- C2 -
1IKI
2
DAC_STRSR
A:
[25-347]
------------------------
G
-
A
M
V
R
-
V
D
D
N
G
T
I
H
Q
L
S
E
G
V
A
D
R
A
T
G
R
A
I
T
T
T
D
R
F
R
V
G
S
V
T
K
S
F
S
A
V
V
L
L
Q
L
V
D
E
G
K
L
D
L
D
A
S
V
N
T
Y
--
L
P
G
L
L
P
D
---
D
R
I
T
V
R
Q
V
M
S
H
R
S
G
L
Y
---------
D
Y
T
----
N
D
M
F
A
----
Q
T
V
P
G
F
--
E
-------
S
V
R
N
K
V
F
S
Y
Q
D
L
I
T
L
S
-
L
K
H
G
-
V
T
N
--
A
P
G
A
A
Y
S
Y
S
N
T
N
F
V
V
A
G
M
L
I
E
K
L
T
G
H
S
V
A
T
E
Y
Q
N
R
I
F
T
P
L
N
L
T
D
T
F
Y
----
V
H
P
D
T
V
-------
I
P
G
T
H
A
N
G
Y
L
T
P
D
E
AGGAL
V
---
D
-
S
T
---
E
Q
T
V
S
--
W
--
A
Q
S
-
A
G
A
V
I
S
S
T
Q
D
L
D
T
F
-------
F
S
A
L
M
S
G
--
Q
L
M
S
A
A
Q
L
A
Q
M
Q
Q
W
T
T
V
N
S
-----
T
Q
G
---
Y
G
L
G
-
L
R
R
R
D
L
-
S
-
C
G
I
S
V
Y
G
H
T
G
T
V
Q
G
Y
Y
T
Y
A
F
A
S
K
D
G
K
R
S
V
T
A
L
A
N
T
S
N
N
V
N
V
L
N
T
-
M
-
A
R
T
L
E
S
A
F
C
G
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
70.52
19%
-1
- C2 -
1EI5
-
DAP_OCHAN
A:
[3-506]
--
K
F
D
T
S
A
L
E
A
F
V
R
H
I
P
Q
N
Y
K
G
P
G
G
-
V
V
A
V
-
V
K
D
G
E
V
V
L
Q
H
A
W
G
F
A
D
L
R
T
R
T
P
M
T
L
D
T
R
M
P
I
C
S
V
S
K
Q
F
T
C
A
V
L
L
D
A
V
G
E
P
E
L
-
L
D
D
A
L
E
A
Y
--
L
D
K
-
F
E
D
---
E
R
P
A
V
R
D
L
C
N
N
Q
S
G
L
R
---------
D
Y
W
----
A
L
S
-
V
----
L
----
C
GA
D
-------
P
--
E
G
V
F
L
P
A
Q
A
Q
S
L
L
---
R
R
L
K
T
T
H
F
E
P
G
S
H
Y
S
Y
C
N
G
N
F
R
I
L
A
D
L
I
E
A
H
T
G
R
T
L
V
D
I
L
S
E
R
I
F
A
P
A
G
M
K
R
A
E
L
I
S
D
T
A
----
L
F
D
E
C
T
G
Y
E
G
D
T
V
R
G
F
L
---------------------
P
A
T
-
N
--
R
I
Q
W
M
G
-
D
A
G
I
C
A
S
L
N
D
M
I
A
W
-------
E
Q
F
I
D
A
T
--
R
D
D
E
S
G
L
Y
R
R
L
S
G
P
Q
T
F
K
D
---
G
V
A
A
P
---
Y
G
F
G
-
L
N
L
H
E
T
-
G
-
G
K
-
R
L
T
G
H
G
G
A
L
R
G
W
R
C
Q
R
W
H
C
A
D
E
R
L
S
T
I
A
M
F
N
F
E
G
G
A
S
--
E
V
---
A
F
K
L
M
N
I
A
L
G
V
S
S
S
E
V
S
R
V
E
AD
S
AW
F
G
S
W
L
D
DETG
L
V
L
S
L
E
D
AGHG
R
M
K
A
R
FGT
S
P
E
M
M
D
V
VSAN
E
A
R
S
AV
T
T
I
R
R
D
GE
T
I
E
L
V
RASEN
L
R
L
S
M
K
R
V
K
G
E
A
K
H
D
I
I
G
R
Y
H
S
D
E
L
D
-
A
D
L
-
L
L
V
S
E
G
G
A
I
Y
G
A
F
E
G
F
LGKS
D
---
M
Y
P
------
L
Y
S
V
G
S
D
V
W
L
L
P
V
------
Q
RSMDAPSPG
E
W
----
K
L
V
F
R
R
D
D
K
G
E
I
T
G
L
S
V
G
--------------------------------------------------------------------------------------------
28
Fugue
70.45
18%
-1
- C2 -
1EI5
-
DAP_OCHAN
A:
[3-520]
--
K
F
D
T
S
A
L
E
A
F
V
R
H
I
-
P
Q
N
Y
K
G
P
G
-
G
V
V
A
V
V
K
D
G
E
V
V
L
Q
H
A
W
G
F
A
D
L
R
T
R
T
P
M
T
L
D
T
R
M
P
I
C
S
V
S
K
Q
F
T
C
A
V
L
L
D
A
V
G
E
P
E
L
-
L
D
D
A
L
E
A
Y
--
L
D
K
-
F
E
D
---
E
R
P
A
V
R
D
L
C
N
N
Q
S
G
L
R
---------
D
Y
W
----
A
L
S
V
L
----
C
----
G
--
A
-------
D
--
P
E
G
V
F
L
P
A
Q
A
Q
S
L
-
L
R
R
L
-
K
T
T
H
F
E
P
G
S
H
Y
S
Y
C
N
G
N
F
R
I
L
A
D
L
I
E
A
H
T
G
R
T
L
V
D
I
L
S
E
R
I
F
A
P
A
G
M
K
R
A
E
L
I
----
S
D
T
A
L
F
D
E
C
T
G
Y
E
G
D
T
V
R
G
F
L
P
A
T
N
R
-----
I
---
Q
----------------
W
M
G
-
D
A
G
I
C
A
S
L
N
D
M
I
A
W
-------
E
Q
F
I
D
A
T
--
R
D
D
E
S
G
L
Y
R
R
L
S
G
P
Q
T
F
K
D
---
G
V
A
A
P
---
Y
G
F
G
-
L
N
L
H
E
T
-
G
-
G
-
K
R
L
T
G
H
G
G
A
L
R
G
W
R
C
Q
R
W
H
C
A
D
E
R
L
S
T
I
A
M
F
N
F
--
E
G
G
A
S
E
V
-
A
-
F
K
L
M
N
I
A
L
G
V
S
S
S
E
V
S
------
R
---------------
V
---------------------
E
----
A
-------
D
S
-
A
----------------
W
F
G
S
W
L
D
D
E
T
G
L
V
L
S
L
E
D
A
G
-
H
-
G
R
M
-
K
A
R
F
G
T
S
P
E
M
M
D
V
V
S
A
----
N
---
E
A
R
S
AV
T
T
I
R
R
D
G
E
T
I
E
L
V
R
A
S
------
E
---------
N
L
----
R
L
S
M
K
R
V
K
G
E
A
K
-
H
D
I
I
G
R
Y
H
S
D
E
L
D
A
D
L
L
L
V
S
E
GG
A
I
Y
G
A
F
E
G
FLGKS
D
M
Y
P
L
Y
S
VGSD
V
W
L
L
P
V
QRSMDAPSPG
E
W
K
L
V
F
R
R
D
DKGEIT
G
L
S
V
G
C
WLARGV
E
Y
R
R
VQP
18
PsiBlast_PDB
70.44
25%
-2
- C2 -
1PWG
1
DAC_STRSR
A:
[25-347]
------------------------
G
-
A
M
V
R
-
V
D
D
N
G
T
I
H
Q
L
S
E
G
V
A
D
R
A
T
G
R
A
I
T
T
T
D
R
F
R
V
G
S
V
T
K
S
F
S
A
V
V
L
L
Q
L
V
D
E
G
K
L
D
L
D
A
S
V
N
T
Y
--
L
P
G
L
L
P
D
---
D
R
I
T
V
R
Q
V
M
S
H
R
S
G
L
Y
---------
D
Y
T
----
N
D
M
F
A
----
Q
T
V
P
G
F
--
E
-------
S
V
R
N
K
V
F
S
Y
Q
D
L
I
T
L
S
-
L
K
H
G
-
V
T
N
--
A
P
G
A
A
Y
S
Y
S
N
T
N
F
V
V
A
G
M
L
I
E
K
L
T
G
H
S
V
A
T
E
Y
Q
N
R
I
F
T
P
L
N
L
T
D
T
F
Y
----
V
H
P
D
T
V
-------
I
P
G
T
H
A
N
G
Y
L
T
P
D
E
AGGAL
V
---
D
-
S
T
---
E
Q
T
V
S
--
W
--
A
Q
S
-
A
G
A
V
I
S
S
T
Q
D
L
D
T
F
-------
F
S
A
L
M
S
G
--
Q
L
M
S
A
A
Q
L
A
Q
M
Q
Q
W
T
T
V
N
S
-----
T
Q
G
---
Y
G
L
G
-
L
R
R
R
D
L
-
S
-
C
G
I
S
V
Y
G
H
T
G
T
V
Q
G
Y
Y
T
Y
A
F
A
S
K
D
G
K
R
S
V
T
A
L
A
N
T
S
N
N
V
N
V
L
N
T
-
M
-
A
R
T
L
E
S
A
F
C
G
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
70.09
25%
-0
- C2 -
1SDE
1
DAC_STRSR
A:
[25-347]
------------------------
G
-
A
M
V
R
-
V
D
D
N
G
T
I
H
Q
L
S
E
G
V
A
D
R
A
T
G
R
A
I
T
T
T
D
R
F
R
V
G
S
V
T
K
S
F
S
A
V
V
L
L
Q
L
V
D
E
G
K
L
D
L
D
A
S
V
N
T
Y
--
L
P
G
L
L
P
D
---
D
R
I
T
V
R
Q
V
M
S
H
R
S
G
L
Y
---------
D
Y
T
----
N
D
M
F
A
----
Q
T
V
P
G
F
--
E
-------
S
V
R
N
K
V
F
S
Y
Q
D
L
I
T
L
S
-
L
K
H
G
-
V
T
N
--
A
P
G
A
A
Y
S
Y
S
N
T
N
F
V
V
A
G
M
L
I
E
K
L
T
G
H
S
V
A
T
E
Y
Q
N
R
I
F
T
P
L
N
L
T
D
T
F
Y
----
V
H
P
D
T
V
-------
I
P
G
T
H
A
N
G
Y
L
T
P
D
E
AGGAL
V
---
D
-
S
T
---
E
Q
T
V
S
--
W
--
A
Q
S
-
A
G
A
V
I
S
S
T
Q
D
L
D
T
F
-------
F
S
A
L
M
S
G
--
Q
L
M
S
A
A
Q
L
A
Q
M
Q
Q
W
T
T
V
N
S
-----
T
Q
G
---
Y
G
L
G
-
L
R
R
R
D
L
-
S
-
C
G
I
S
V
Y
G
H
T
G
T
V
Q
G
Y
Y
T
Y
A
F
A
S
K
D
G
K
R
S
V
T
A
L
A
N
T
S
N
N
V
N
V
L
N
T
-
M
-
A
R
T
L
E
S
A
F
C
G
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
69.85
25%
-0
- C2 -
1SCW
6
DAC_STRSR
A:
[25-347]
------------------------
G
-
A
M
V
R
-
V
D
D
N
G
T
I
H
Q
L
S
E
G
V
A
D
R
A
T
G
R
A
I
T
T
T
D
R
F
R
V
G
S
V
T
K
S
F
S
A
V
V
L
L
Q
L
V
D
E
G
K
L
D
L
D
A
S
V
N
T
Y
--
L
P
G
L
L
P
D
---
D
R
I
T
V
R
Q
V
M
S
H
R
S
G
L
Y
---------
D
Y
T
----
N
D
M
F
A
----
Q
T
V
P
G
F
--
E
-------
S
VR
N
K
V
F
S
Y
Q
D
L
I
T
L
S
-
L
K
H
G
-
V
T
N
--
A
P
G
A
A
Y
S
Y
S
N
T
N
F
V
V
A
G
M
L
I
E
K
L
T
G
H
S
V
A
T
E
Y
Q
N
R
I
F
T
P
L
N
L
T
D
T
F
Y
----
V
H
P
D
T
V
-------
I
P
G
T
H
A
N
G
Y
L
T
P
D
E
AGGAL
V
---
D
-
S
T
---
E
Q
T
V
S
--
W
--
A
Q
S
-
A
G
A
V
I
S
S
T
Q
D
L
D
T
F
-------
F
S
A
L
M
S
G
--
Q
L
M
S
A
A
Q
L
A
Q
M
Q
Q
W
T
T
V
N
S
-----
T
Q
G
---
Y
G
L
G
-
L
R
R
R
D
L
-
S
-
C
G
I
S
V
Y
G
H
T
G
T
V
Q
G
Y
Y
T
Y
A
F
A
S
K
D
G
K
R
S
V
T
A
L
A
N
T
S
N
N
V
N
V
L
N
T
-
M
-
A
R
T
L
E
S
A
F
C
G
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
69.62
25%
-1
- C2 -
1MPL
6
DAC_STRSR
A:
[25-347]
------------------------
G
-
A
M
V
R
-
V
D
D
N
G
T
I
H
Q
L
S
E
G
V
A
D
R
A
T
G
R
A
I
T
T
T
D
R
F
R
V
G
S
V
T
K
S
F
S
A
V
V
L
L
Q
L
V
D
E
G
K
L
D
L
D
A
S
V
N
T
Y
--
L
P
G
L
L
P
D
---
D
R
I
T
V
R
Q
V
M
S
H
R
S
G
L
Y
---------
D
Y
T
----
N
D
M
F
A
----
Q
T
V
P
G
F
--
E
-------
S
V
R
N
K
V
F
S
Y
Q
D
L
I
T
L
S
-
L
K
H
G
-
V
T
N
--
A
P
G
A
A
Y
S
Y
S
N
T
N
F
V
V
A
G
M
L
I
E
K
L
T
G
H
S
V
A
T
E
Y
Q
N
R
I
F
T
P
L
N
L
T
D
T
F
Y
----
V
H
P
D
T
V
-------
I
P
G
T
H
A
N
G
Y
L
T
P
D
E
AGGAL
V
---
D
-
S
T
---
E
Q
T
V
S
--
W
--
A
Q
S
-
A
G
A
V
I
S
S
T
Q
D
L
D
T
F
-------
F
S
A
L
M
S
G
--
Q
L
M
S
A
A
Q
L
A
Q
M
Q
Q
W
T
T
V
N
S
-----
T
Q
G
---
Y
G
L
G
-
L
R
R
R
D
L
-
S
-
C
G
I
S
V
Y
G
H
T
G
T
V
Q
G
Y
Y
T
Y
A
F
A
S
K
D
G
K
R
S
V
T
A
L
A
N
T
S
N
N
V
N
V
L
N
T
-
M
-
A
R
T
L
E
S
A
F
C
G
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
69.61
25%
-0
- C2 -
1PW1
6
DAC_STRSR
A:
[25-347]
------------------------
G
-
A
M
V
R
-
V
D
D
N
G
T
I
H
Q
L
S
E
G
V
A
D
R
A
T
G
R
A
I
T
T
T
D
R
F
R
V
G
S
V
T
K
S
F
S
A
V
V
L
L
Q
L
V
D
E
G
K
L
D
L
D
A
S
V
N
T
Y
--
L
P
G
L
L
P
D
---
D
R
I
T
V
R
Q
V
M
S
H
R
S
G
L
Y
---------
D
Y
T
----
N
D
M
F
A
----
Q
T
V
P
G
F
--
E
-------
S
VR
N
K
V
F
S
Y
Q
D
L
I
T
L
S
-
L
K
H
G
-
V
T
N
--
A
P
G
A
A
Y
S
Y
S
N
T
N
F
V
V
A
G
M
L
I
E
K
L
T
G
H
S
V
A
T
E
Y
Q
N
R
I
F
T
P
L
N
L
T
D
T
F
Y
----
V
H
P
D
T
V
-------
I
P
G
T
H
A
N
G
Y
L
T
P
D
E
AGGAL
V
---
D
-
S
T
---
E
Q
T
V
S
--
W
--
A
Q
S
-
A
G
A
V
I
S
S
T
Q
D
L
D
T
F
-------
F
S
A
L
M
S
G
--
Q
L
M
S
A
A
Q
L
A
Q
M
Q
Q
W
T
T
V
N
S
-----
T
Q
G
---
Y
G
L
G
-
L
R
R
R
D
L
-
S
-
C
G
I
S
V
Y
G
H
T
G
T
V
Q
G
Y
Y
T
Y
A
F
A
S
K
D
G
K
R
S
V
T
A
L
A
N
T
S
N
N
V
N
V
L
N
T
-
M
-
A
R
T
L
E
S
A
F
C
G
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
69.57
25%
0
- C2 -
1PWD
1
DAC_STRSR
A:
[25-347]
------------------------
G
-
A
M
V
R
-
V
D
D
N
G
T
I
H
Q
L
S
E
G
V
A
D
R
A
T
G
R
A
I
T
T
T
D
R
F
R
V
G
S
V
T
K
S
F
S
A
V
V
L
L
Q
L
V
D
E
G
K
L
D
L
D
A
S
V
N
T
Y
--
L
P
G
L
L
P
D
---
D
R
I
T
V
R
Q
V
M
S
H
R
S
G
L
Y
---------
D
Y
T
----
N
D
M
F
A
----
Q
T
V
P
G
F
--
E
-------
S
V
R
N
K
V
F
S
Y
Q
D
L
I
T
L
S
-
L
K
H
G
-
V
T
N
--
A
P
G
A
A
Y
S
Y
S
N
T
N
F
V
V
A
G
M
L
I
E
K
L
T
G
H
S
V
A
T
E
Y
Q
N
R
I
F
T
P
L
N
L
T
D
T
F
Y
----
V
H
P
D
T
V
-------
I
P
G
T
H
A
N
G
Y
L
T
P
D
E
AGGAL
V
---
D
-
S
T
---
E
Q
T
V
S
--
W
--
A
Q
S
-
A
G
A
V
I
S
S
T
Q
D
L
D
T
F
-------
F
S
A
L
M
S
G
--
Q
L
M
S
A
A
Q
L
A
Q
M
Q
Q
W
T
T
V
N
S
-----
T
Q
G
---
Y
G
L
G
-
L
R
R
R
D
L
-
S
-
C
G
I
S
V
Y
G
H
T
G
T
V
Q
G
Y
Y
T
Y
A
F
A
S
K
D
G
K
R
S
V
T
A
L
A
N
T
S
N
N
V
N
V
L
N
T
-
M
-
A
R
T
L
E
S
A
F
C
G
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
69.27
24%
6
- C2 -
1YQS
4
DAC_STRSR
A:
[5-346]
--
A
P
D
D
T
G
L
Q
A
V
L
H
T
A
-
L
S
Q
G
A
P
G
A
-
M
V
R
V
-
D
D
N
G
T
-
I
H
Q
L
S
E
G
V
A
D
R
A
T
G
R
A
I
T
T
T
D
R
F
R
V
G
S
V
T
K
S
F
S
A
V
V
L
L
Q
L
V
D
E
G
K
L
D
L
D
A
S
V
N
T
Y
--
L
P
G
-
L
L
P
D--
D
R
I
T
V
R
Q
V
M
S
H
R
S
G
L
Y
---------
D
Y
T
----
N
D
M
F
A
QT
V
P
G
----
F
--
E
S
V
-----
R
--
N
K
V
F
S
Y
Q
D
L
I
T
L
S
---
L
K
-
H
G
V
T
N
A
P
G
A
A
Y
S
Y
S
N
T
N
F
V
V
A
G
M
L
I
E
K
L
T
G
H
S
V
A
T
E
Y
Q
N
R
I
F
T
P
L
N
L
T
D
T
F
Y
V
H
P
D
T
V
--
I
P
G
T
H
A
N
G
Y
L
T
P
D
E
A
G
G
A
L
----------------
V
---
D
S
T
E
Q
T-
V
S
W
A
Q
S
-
A
G
A
V
I
S
S
T
Q
D
L
D
T
F
-------
F
S
A
L
M
S
G
--
Q
L
M
S
A
A
Q
L
A
Q
M
Q
Q
W
T
T
V
-----
N
S
T
Q
G
---
Y
G
L
G
-
L
R
R
R
D
L
-
S
C
G
I
-
S
V
Y
G
H
T
G
T
V
Q
G
Y
Y
T
Y
A
F
A
S
K
D
G
K
R
S
V
T
A
L
A
N
T
S
N
N
V
N
V
-
L
N
-
T
M
A
R
T
L
E
S
A
F
C
G
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
69.05
25%
1
- C2 -
1HVB
1
DAC_STRSR
A:
[25-347]
------------------------
G
-
A
M
V
R
-
V
D
D
N
G
T
I
H
Q
L
S
E
G
V
A
D
R
A
T
G
R
A
I
T
T
T
D
R
F
R
V
G
S
V
T
K
S
F
S
A
V
V
L
L
Q
L
V
D
E
G
K
L
D
L
D
A
S
V
N
T
Y
--
L
P
G
L
L
P
D
---
D
R
I
T
V
R
Q
V
M
S
H
R
S
G
L
Y
---------
D
Y
T
----
N
D
M
F
A
----
Q
T
V
P
G
F
--
E
-------
S
VR
N
K
V
F
S
Y
Q
D
L
I
T
L
S
-
L
K
H
G
-
V
T
N
--
A
P
G
A
A
Y
S
Y
S
N
T
N
F
V
V
A
G
M
L
I
E
K
L
T
G
H
S
V
A
T
E
Y
Q
N
R
I
F
T
P
L
N
L
T
D
T
F
Y
----
V
H
P
D
T
V
-------
I
P
G
T
H
A
N
G
Y
L
T
P
D
E
AGGAL
V
---
D
-
S
T
---
E
Q
T
V
S
--
W
--
A
Q
S
-
A
G
A
V
I
S
S
T
Q
D
L
D
T
F
-------
F
S
A
L
M
S
G
--
Q
L
M
S
A
A
Q
L
A
Q
M
Q
Q
W
T
T
V
N
S
-----
T
Q
G
---
Y
G
L
G
-
L
R
R
R
D
L
-
S
-
C
G
I
S
V
Y
G
H
T
G
T
V
Q
G
Y
Y
T
Y
A
F
A
S
K
D
G
K
R
S
V
T
A
L
A
N
T
S
N
N
V
N
V
L
N
T
-
M
-
A
R
T
L
E
S
A
F
C
G
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
68.99
25%
-1
- C2 -
1PW8
3
DAC_STRSR
A:
[25-347]
------------------------
G
-
A
M
V
R
-
V
D
D
N
G
T
I
H
Q
L
S
E
G
V
A
D
R
A
T
G
R
A
I
T
T
T
D
R
F
R
V
G
S
V
T
K
S
F
S
A
V
V
L
L
Q
L
V
D
E
G
K
L
D
L
D
A
S
V
N
T
Y
--
L
P
G
L
L
P
D
---
D
R
I
T
V
R
Q
V
M
S
H
R
S
G
L
Y
---------
D
Y
T
----
N
D
M
F
A
----
Q
T
V
P
G
F
--
E
-------
S
VR
N
K
V
F
S
Y
Q
D
L
I
T
L
S
-
L
K
H
G
-
V
T
N
--
A
P
G
A
A
Y
S
Y
S
N
T
N
F
V
V
A
G
M
L
I
E
K
L
T
G
H
S
V
A
T
E
Y
Q
N
R
I
F
T
P
L
N
L
T
D
T
F
Y
----
V
H
P
D
T
V
-------
I
P
G
T
H
A
N
G
Y
L
T
P
D
E
AGGAL
V
---
D
-
S
T
---
E
Q
T
V
S
--
W
--
A
Q
S
-
A
G
A
V
I
S
S
T
Q
D
L
D
T
F
-------
F
S
A
L
M
S
G
--
Q
L
M
S
A
A
Q
L
A
Q
M
Q
Q
W
T
T
V
N
S
-----
T
Q
G
---
Y
G
L
G
-
L
R
R
R
D
L
-
S
-
C
G
I
S
V
Y
G
H
T
G
T
V
Q
G
Y
Y
T
Y
A
F
A
S
K
D
G
K
R
S
V
T
A
L
A
N
T
S
N
N
V
N
V
L
N
T
-
M
-
A
R
T
L
E
S
A
F
C
G
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
68.95
25%
-1
- C2 -
1PWC
1
DAC_STRSR
A:
[25-347]
------------------------
G
-
A
M
V
R
-
V
D
D
N
G
T
I
H
Q
L
S
E
G
V
A
D
R
A
T
G
R
A
I
T
T
T
D
R
F
R
V
G
S
V
T
K
S
F
S
A
V
V
L
L
Q
L
V
D
E
G
K
L
D
L
D
A
S
V
N
T
Y
--
L
P
G
L
L
P
D
---
D
R
I
T
V
R
Q
V
M
S
H
R
S
G
L
Y
---------
D
Y
T
----
N
D
M
F
A
----
Q
T
V
P
G
F
--
E
-------
S
V
R
N
K
V
F
S
Y
Q
D
L
I
T
L
S
-
L
K
H
G
-
V
T
N
--
A
P
G
A
A
Y
S
Y
S
N
T
N
F
V
V
A
G
M
L
I
E
K
L
T
G
H
S
V
A
T
E
Y
Q
N
R
I
F
T
P
L
N
L
T
D
T
F
Y
----
V
H
P
D
T
V
-------
I
P
G
T
H
A
N
G
Y
L
T
P
D
E
AGGAL
V
---
D
-
S
T
---
E
Q
T
V
S
--
W
--
A
Q
S
-
A
G
A
V
I
S
S
T
Q
D
L
D
T
F
-------
F
S
A
L
M
S
G
--
Q
L
M
S
A
A
Q
L
A
Q
M
Q
Q
W
T
T
V
N
S
-----
T
Q
G
---
Y
G
L
G
-
L
R
R
R
D
L
-
S
-
C
G
I
S
V
Y
G
H
T
G
T
V
Q
G
Y
Y
T
Y
A
F
A
S
K
D
G
K
R
S
V
T
A
L
A
N
T
S
N
N
V
N
V
L
N
T
-
M
-
A
R
T
L
E
S
A
F
C
G
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
68.53
25%
1
- C2 -
1YQS
4
DAC_STRSR
A:
[25-347]
------------------------
G
-
A
M
V
R
-
V
D
D
N
G
T
I
H
Q
L
S
E
G
V
A
D
R
A
T
G
R
A
I
T
T
T
D
R
F
R
V
G
S
V
T
K
S
F
S
A
V
V
L
L
Q
L
V
D
E
G
K
L
D
L
D
A
S
V
N
T
Y
--
L
P
G
L
L
P
D
---
D
R
I
T
V
R
Q
V
M
S
H
R
S
G
L
Y
---------
D
Y
T
----
N
D
M
F
A
----
Q
T
V
P
G
F
--
E
-------
S
V
R
N
K
V
F
S
Y
Q
D
L
I
T
L
S
-
L
K
H
G
-
V
T
N
--
A
P
G
A
A
Y
S
Y
S
N
T
N
F
V
V
A
G
M
L
I
E
K
L
T
G
H
S
V
A
T
E
Y
Q
N
R
I
F
T
P
L
N
L
T
D
T
F
Y
----
V
H
P
D
T
V
-------
I
P
G
T
H
A
N
G
Y
L
T
P
D
E
AGGAL
V
---
D
-
S
T
---
E
Q
T
V
S
--
W
--
A
Q
S
-
A
G
A
V
I
S
S
T
Q
D
L
D
T
F
-------
F
S
A
L
M
S
G
--
Q
L
M
S
A
A
Q
L
A
Q
M
Q
Q
W
T
T
V
N
S
-----
T
Q
G
---
Y
G
L
G
-
L
R
R
R
D
L
-
S
-
C
G
I
S
V
Y
G
H
T
G
T
V
Q
G
Y
Y
T
Y
A
F
A
S
K
D
G
K
R
S
V
T
A
L
A
N
T
S
N
N
V
N
V
L
N
T
-
M
-
A
R
T
L
E
S
A
F
C
G
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
68.20
28%
-66
- C2 -
3TG9
-
?
A:
[2-278]
-----
K
N
H
L
H
T
I
M
E
D
W
-----
K
L
S
G
-
T
A
L
M
-
K
K
G
E
D
I
P
F
I
A
S
L
G
F
A
N
R
A
E
R
I
P
N
E
H
H
T
R
F
G
I
A
S
G
C
K
L
F
T
A
I
A
I
C
Q
L
V
E
A
G
K
L
S
F
D
T
P
L
S
D
W
--
L
D
A
--
P
F
---
P
N
V
T
I
H
H
L
L
T
H
T
S
G
V
P
---------
D
Y
F
----
D
---------EDL-
W
--
K
-------
D
--
V
P
M
Y
H
L
R
R
L
K
D
F
L
P
L
F
Q
H
-
A
P
M
K
F
P
P
G
H
R
F
H
Y
N
N
A
G
F
I
L
L
G
L
V
V
E
S
V
S
G
V
T
F
Q
E
Y
V
E
A
N
V
F
Q
R
A
G
M
H
E
S
G
Y
F
A
F
D
T
L
P
A
K
T
---
A
L
G
Y
I
--------
D
L
E
D
G
-----
S
---
W
-
K
T
---
N
-
L
Y
S
--
L
P
V
I
G
G
S
D
G
G
A
Y
V
T
A
E
D
M
M
K
L
-------
W
L
A
L
M
R
H
--
E
L
L
N
E
T
Y
T
Q
K
L
L
T
P
-
H
V
H
C
---
E
D
D
D
Y
---
Y
G
Y
G
V
W
I
K
Q
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
67.93
25%
-1
- C2 -
1IKG
1
DAC_STRSR
A:
[25-347]
------------------------
G
-
A
M
V
R
-
V
D
D
N
G
T
I
H
Q
L
S
E
G
V
A
D
R
A
T
G
R
A
I
T
T
T
D
R
F
R
V
G
S
V
T
K
S
F
S
A
V
V
L
L
Q
L
V
D
E
G
K
L
D
L
D
A
S
V
N
T
Y
--
L
P
G
L
L
P
D
---
D
R
I
T
V
R
Q
V
M
S
H
R
S
G
L
Y
---------
D
Y
T
----
N
D
M
F
A
----
Q
T
V
P
G
F
--
E
-------
S
VR
N
K
V
F
S
Y
Q
D
L
I
T
L
S
-
L
K
H
G
-
V
T
N
--
A
P
G
A
A
Y
S
Y
S
N
T
N
F
V
V
A
G
M
L
I
E
K
L
T
G
H
S
V
A
T
E
Y
Q
N
R
I
F
T
P
L
N
L
T
D
T
F
Y
----
V
H
P
D
T
V
-------
I
P
G
T
H
A
N
G
Y
L
T
P
D
E
AGGAL
V
---
D
-
S
T
---
E
Q
T
V
S
--
W
--
A
Q
S
-
A
G
A
V
I
S
S
T
Q
D
L
D
T
F
-------
F
S
A
L
M
S
G
--
Q
L
M
S
A
A
Q
L
A
Q
M
Q
Q
W
T
T
V
N
S
-----
T
Q
G
---
Y
G
L
G
-
L
R
R
R
D
L
-
S
-
C
G
I
S
V
Y
G
H
T
G
T
V
Q
G
Y
Y
T
Y
A
F
A
S
K
D
G
K
R
S
V
T
A
L
A
N
T
S
N
N
V
N
V
L
N
T
-
M
-
A
R
T
L
E
S
A
F
C
G
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------