@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu34610: (2016-07-28 )
MVLLKKGFAILAASFLAIGLAACSSSKNPASSDGKKVLTVSVEETYKEYIESIKTKFEKENDVTVKIVEKQMFEQLEALPLDGPAGNAPDVMLAAYDRIGGLGQQGHLLDIKPSNTKSFGDKEMQQVTVDGKVYGMPLVIETLILYYNKDLLKTAPKTFKDLEKLTEDPRFAFASEKGKSTGFLAKWTDFYMSYGLLAGYGGYVFGKNGTDSGDIGLNNKGAVEAVKYAEKWFETYWPKGMQDNSSADDFIQQMFLEGKAAAIIGGPWSAANYKEAKLNYGAAPIPTLPNGEEYAPFAGGKGWVASKYTKEPELAEKWLEYAANDANAYAFYEDTNEVPANTAARKKADEQKNELTSAVIKQYETATPTPNIPEMAEVWTGAESLIFDAASGKKSTQTSANDAVNVIKENIKEKYVK
Atome Classification :
(22 SA)
.........10........20........30......--..40..-.-.--....50.....-----...60........70........80..-......90...-.....100......--.110--.--.---.---.--.--..120----......-.130.......140.......150.......160.----......170.......180---........190.......200.-...-..--.---210.........220.......230.-.--.-....240.......250........260.......270....-...280.......290.-......300.......310.......-320-........330.......340.....-..350.--........360.......370.......380.......390..-.....400.......410.-----....----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MVLLKK
G
F
A
I
L
A
A
S
F
L
A
I
G
L
A
ACSSSKNPASSDG
K
K
V
--
L
T
V
S
V
E
-
E
-
T
--
Y
K
E
Y
I
E
S
I
K
T
K
-----FEKEN
D
V
T
V
K
I
V
E
K
Q
M
F
E
Q
L
E
ALPLDG-PAGNAP
D
V
M
L
A
-
A
Y
D
RIGGLGQQG
H
L
--
L
D
IK--P--S---N---T--K--SFG
D
K
----
E
M
Q
Q
V
T
-VD
G
K
VY
G
M
P
L
V
I
E
T
L
I
L
Y
YN
K
D
L
L
K
TA
P
K
T
F
K
D
L
E
----
K
LTEDP
R
F
A
FASEKGKST----GF
L
A
K
W
T
D
F
Y
M
S
Y
G
LLAGYG
G
Y
-
V
FG-KN--G---T--DSGDIGLNNK
G
A
V
E
A
V
K
Y
A
E
K
W
F
-
E
--
T
-YWPKGMQDNS
S
A
D
D
F
I
-
Q
Q
M
F
LEGK
A
A
A
I
IGGPWSAANY
K
E
A
-KLNYGAAPIPTLPNGEE-YAPFAGGKG
W
V
ASKYTKE
P
E
L
A
E
K
W
L
-
E
-
Y
-AANDA
N
A
Y
A
F
YEDTNEVPA
N
T
A
ARKK-
A
D
E
--
Q
--
K
N
E
L
T
S
A
V
I
K
Q
YETATPTPN
I
P
E
M
A
E
V
WT
G
A
E
S
L
I
F
DAASGKK-STQTSA
N
D
A
V
N
V
I
K
E
N
I
K
E
-----KYVK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
93.02
51%
-4
- C1 -
2XD3
3
MALX_STRPN
A:
[36-410]
------------------------------------
E
--
L
T
V
Y
V
D
-
E
-
G
--
Y
K
S
Y
I
E
E
V
A
K
A
-----
Y
E
K
E
A
G
V
K
V
T
L
K
T
G
D
A
L
G
G
L
D
K
L
S
L
D
N
-
Q
N
G
N
V
P
D
V
M
M
A
-
P
Y
D
R
V
G
S
L
G
S
D
G
Q
L
--
S
E
V
K
--
L
--
S
---
D
GAK
T
--
D
--
D
T
T
K
S
----
L
V
--
T
A
-
A
N
G
K
V
Y
G
A
P
A
V
I
E
S
L
V
M
Y
Y
N
K
D
L
V
K
D
A
P
K
T
F
A
D
L
E
----
N
L
A
K
D
S
K
Y
A
F
A
G
E
D
G
K
T
T
----
A
F
L
A
D
W
T
N
F
Y
Y
T
Y
G
L
L
A
G
N
G
A
Y
-
V
F
G
-
Q
N
--
G
---
K
--
D
A
K
D
I
G
L
A
N
D
G
S
I
V
G
I
N
Y
A
K
S
W
Y
-
E
----
K
W
P
K
G
M
Q
D
T
E
G
A
G
N
L
I
-
Q
T
Q
F
Q
E
G
K
T
A
A
I
I
D
G
P
W
K
A
Q
A
F
K
D
A
-
K
V
N
Y
G
V
A
T
I
P
T
L
P
N
G
K
E
-
Y
A
A
F
G
G
G
K
A
W
V
I
P
Q
A
V
K
N
L
E
A
S
Q
K
F
V
-
D
-
F
-
L
V
A
T
E
Q
Q
K
V
L
Y
D
K
T
N
E
I
P
A
N
T
E
A
R
S
Y
A
E
G
---
K
--
N
D
E
L
T
T
A
V
I
K
Q
F
K
N
T
Q
P
L
P
N
I
S
Q
M
S
A
V
W
D
P
A
K
N
M
L
F
D
A
V
S
G
Q
K
-
D
A
K
T
A
A
N
D
A
V
T
L
I
K
E
T
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
78.15
51%
46
- C1 -
2XD2
-
MALX_STRPN
A:
[41-419]
-------------------------------------K
E
L
T
V
Y
V
D
-
E
-
G
--
Y
K
S
Y
I
E
E
V
A
K
A
-----
Y
E
K
E
A
G
V
K
V
T
L
K
T
G
D
A
L
G
G
L
D
K
L
S
L
D
N
-
Q
N
G
N
V
P
D
V
M
M
A
-
P
Y
D
R
V
G
S
L
G
S
D
G
Q
L
--
S
E
V
K
--
L
--
S
---
D
---
G
--
A
--
K
T
D
D
T
----
T
K
S
L
V
T
A
A
N
G
K
V
Y
G
A
P
A
V
I
E
S
L
V
M
Y
Y
N
K
D
L
V
K
D
A
P
K
T
F
A
D
L
E
----
N
L
A
K
D
S
K
Y
A
F
A
G
E
D
G
K
T
T
----
A
F
L
A
D
W
T
N
F
Y
Y
T
Y
G
L
L
A
G
N
G
A
Y
-
V
F
G
-
Q
N
--
G
---
K
--
D
A
K
D
I
G
L
A
N
D
G
S
I
V
G
I
N
Y
A
K
S
W
Y
-
E
--
K
--
W
P
K
G
M
Q
D
T
E
G
A
G
N
L
I
-
Q
T
Q
F
Q
E
G
K
T
A
A
I
I
D
G
P
W
K
A
Q
A
F
K
D
A
-
K
V
N
Y
G
V
A
T
I
P
T
L
P
N
G
K
E
-
Y
A
A
F
G
G
G
K
A
W
V
I
P
Q
A
V
K
N
L
E
A
S
Q
K
F
V
-
D
-
F
-
L
V
A
T
E
Q
Q
K
V
L
Y
D
K
T
N
E
I
P
A
N
T
E
A
R
S
Y
-
A
E
G
--
K
--
N
D
E
L
T
T
A
V
I
K
Q
F
K
N
T
Q
P
L
P
N
I
S
Q
M
S
A
V
W
D
P
A
K
N
M
L
F
D
A
V
S
G
Q
K
-
D
A
K
T
A
A
N
D
A
V
T
L
I
K
E
T
L
K
Q
-----
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
75.83
28%
-6
- C1 -
2GHA
1
?
A:
[3-374]
-----------------------------------
P
K
--
L
T
I
W
C
S
-
E
-
K
--
Q
V
D
I
L
Q
K
L
G
E
E
-----
F
K
A
K
Y
G
V
E
V
E
V
Q
Y
V
N
F
Q
D
I
K
S
K
F
L
T
A
A
-
P
E
G
Q
G
A
D
I
I
V
G
-
A
H
D
W
V
G
E
L
A
V
N
G
L
I
--
E
P
I
P
--
N
--
F
S--
D
---
L
--
K
--
N
F
Y
E
T
----
A
L
N
A
F
S
-
Y
G
G
K
L
Y
G
I
P
Y
A
M
E
A
I
A
L
I
Y
N
K
D
Y
V
P
E
P
P
K
T
M
D
E
L
I
----
E
I
A
K
Q
I
D
E
E
F
G
--
G
E
V
-
R
----
G
F
I
T
S
A
A
E
F
Y
Y
I
A
P
F
I
F
G
Y
G
G
Y
-
V
F
K
-
Q
T
--
E
KG-
L
--
D
V
N
D
I
G
L
A
N
E
G
A
I
K
G
V
K
L
L
K
R
L
V
-
D
E
-
G
-
I
L
D
P
S
D
N
-----
Y
Q
I
M
-
D
S
M
F
R
E
G
Q
A
A
M
I
I
N
G
P
W
A
I
K
A
Y
K
D
A
-
G
I
D
Y
G
V
A
P
I
P
D
L
E
P
G
V
P
-
A
R
P
F
V
G
V
Q
G
F
M
V
N
A
K
S
P
N
K
L
L
A
I
E
F
L
-
T
-
S
F
I
A
K
K
E
T
M
Y
R
I
Y
L
G
D
P
R
L
P
S
R
K
D
V
L
E
L
--
V
---
K
--
D
N
P
D
V
V
G
F
T
L
S
A
A
N
G
I
P
M
P
N
V
P
Q
M
A
A
V
W
A
A
M
N
D
A
L
N
L
V
V
N
G
K
A
-
T
V
E
E
A
L
K
N
A
V
E
R
I
K
A
Q
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
73.26
51%
65
- C1 -
2XD3
3
MALX_STRPN
A:
[36-410]
-------------------------------------E-
L
T
V
Y
V
D
-
E
-
G
--
Y
K
S
Y
I
E
E
V
A
K
A
-----
Y
E
K
E
A
G
V
K
V
T
L
K
T
G
D
A
L
G
G
L
D
K
L
S
L
D
N
-
Q
N
G
N
V
P
D
V
M
M
A
-
P
Y
D
R
V
G
S
L
G
S
D
G
Q
L
--
S
E
V
K
--
L
--
S
---
D
---
G
--
A
--
K
T
D
D
T
----
T
K
S
L
V
T
A
A
N
G
K
V
Y
G
A
P
A
V
I
E
S
L
V
M
Y
Y
N
K
D
L
V
K
D
A
P
K
T
F
A
D
L
E
----
N
L
A
K
D
S
K
Y
A
F
A
G
E
D
G
K
T
T
----
A
F
L
A
D
W
T
N
F
Y
Y
T
Y
G
L
L
A
G
N
G
A
Y
-
V
F
G
-
Q
N
--
G
---
K
--
D
A
K
D
I
G
L
A
N
D
G
S
I
V
G
I
N
Y
A
K
S
W
Y
-
E
--
K
--
W
P
K
G
M
Q
D
T
E
G
A
G
N
L
I
-
Q
T
Q
F
Q
E
G
K
T
A
A
I
I
D
G
P
W
K
A
Q
A
F
K
D
A
-
K
V
N
Y
G
V
A
T
I
P
T
L
P
N
G
K
E
-
Y
A
A
F
G
G
G
K
A
W
V
I
P
Q
A
V
K
N
L
E
A
S
Q
K
F
V
-
D
-
F
-
L
V
A
T
E
Q
Q
K
V
L
Y
D
K
T
N
E
I
P
A
N
T
E
A
R
S
Y
-
A
E
G
--
K
--
N
D
E
L
T
T
A
V
I
K
Q
F
K
N
T
Q
P
L
P
N
I
S
Q
M
S
A
V
W
D
P
A
K
N
M
L
F
D
A
V
S
G
Q
K
-
D
A
K
T
A
A
N
D
A
V
T
L
I
K
E
T
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
69.70
23%
8
- C1 -
3PY7
3
MALE_ECOLI (first)
A:
[3-516]
-------------------------------
I
E
E
G
K
L
--
V
I
W
I
N
G
-
D
-
K
--
G
Y
N
G
L
A
E
V
G
K
K
-----
F
E
K
D
T
G
I
K
V
T
V
E
H
P
D
--
K
L
E
E
K
F
P
Q
V
A
-
A
T
G
D
G
P
D
I
I
F
W
-
A
H
D
R
F
G
G
Y
A
Q
S
G
L
L
--
A
E
I
T
--
P
--
A
---
A
---
A
--
F
Q
D
K
L
Y
P
F
----
T
W
D
A
V
R
-
Y
N
G
K
L
I
A
Y
P
I
A
V
E
A
L
S
L
I
Y
N
K
D
L
L
P
N
P
P
K
T
W
E
E
I
P
----
A
L
D
K
E
L
K
------
A
K
G
K
S
----
A
L
M
F
N
L
Q
E
P
Y
F
T
W
P
L
I
A
A
D
G
G
Y
-
A
F
K
-
Y
E
--
N
GK-
Y
--
D
I
K
D
V
G
V
D
N
A
G
A
K
A
G
L
T
F
L
V
D
L
I
-
K
-------
N
K
H
M
N
A
D
T
D
Y
S
I
A
-
E
A
A
F
N
K
G
E
T
A
M
T
I
N
G
P
W
A
W
S
N
I
D
T
S
-
A
V
N
Y
G
V
T
V
L
P
T
F
-
K
G
Q
P
-
S
K
P
F
V
G
V
L
S
A
G
I
N
A
A
S
P
N
K
E
L
A
K
E
F
L
-
E
-
N
-
Y
L
L
T
D
E
G
L
E
A
V
N
K
D
K
P
L
G
A
V
A
L
K
S
Y
E
-
E
E
L
--
A
--
K
D
P
R
I
A
A
T
M
E
N
A
Q
K
G
E
I
M
P
N
I
P
Q
M
S
A
F
W
Y
A
V
R
T
A
V
I
N
A
A
S
G
R
Q
-
T
V
D
A
A
L
A
A
A
Q
T
N
A
A
A
M
D
D
L
-----
D
A
L
L
ADKPFSGLDCLWCREPLT
E
V
D
A
F
R
C
M
V
K
D
F
H
V
V
I
R
EG
C
R
Y
G
A
C
T
I
C
L
E
N
C
L
A
T
E
R
R
L
W
QGVPVT
G
E
E
A
E
L
L
H
GKTLDRLCIRCCYCGGKLT
K
N
E
K
H
R
H
V
L
F
N
E
P
F
C
K
T
R
AN
I
I
R
G
R
C
YDCCRH-------------------------------------------------------------------
46
Fugue
68.37
24%
10
- C1 -
3D4G
4
ZP3_MOUSE
A:
[3-473]
-------------------------------
T
E
E
G
K
L
--
V
I
W
I
N
G
-
D
-
K
--
G
Y
N
G
L
A
E
V
G
K
K
-----
F
E
K
D
T
G
I
K
V
T
V
E
H
P
D
--
K
L
E
E
K
F
P
Q
V
A
-
A
T
G
D
G
P
D
I
I
F
W
-
A
H
D
R
F
G
G
Y
A
Q
S
G
L
L
--
A
E
I
T
--
P
D
K
A
---
F
---
Q
--
D
--
K
L
Y
P
F
----
T
W
D
A
V
R
-
Y
N
G
K
L
I
A
Y
P
I
A
V
E
A
L
S
L
I
Y
N
K
D
L
L
P
N
P
P
K
T
W
E
E
I
P
----
A
L
D
K
E
L
K
A
------
K
G
K
S
----
A
L
M
F
N
L
Q
E
P
Y
F
T
W
P
L
I
A
A
D
G
G
Y
-
A
F
K
-
Y
E
--
N
GK-
Y
--
D
I
K
D
V
G
V
D
N
A
G
A
K
A
G
L
T
F
L
V
D
L
I
-
K
-------
N
K
H
M
N
A
D
T
D
Y
S
I
A
-
E
A
A
F
N
K
G
E
T
A
M
T
I
N
G
P
W
A
W
S
N
I
D
T
S
-
K
V
N
Y
G
V
T
V
L
P
T
F
-
K
G
Q
P
-
S
K
P
F
V
G
V
L
S
A
G
I
N
A
A
S
P
N
K
E
L
A
K
E
F
L
-
E
-
N
-
Y
L
L
T
D
E
G
L
E
A
V
N
K
D
K
P
L
G
A
V
A
L
K
S
Y
E
-
E
E
L
--
A
--
K
D
P
R
I
A
A
T
M
E
N
A
Q
K
G
E
I
M
P
N
I
P
Q
M
S
A
F
W
Y
A
V
R
T
A
V
I
N
A
A
S
G
R
Q
-
T
V
D
A
A
L
A
A
A
Q
T
N
A
A
A
V
K
V
E
C
L
EA
E
L
V
V
T
V
S
RDLFGTG
K
L
V
Q
PGDLTLGSEGCQ
P
R
V
S
V
D
TD
V
V
R
F
NAQLHECSS
R
V
Q
M
T
KD
A
L
V
Y
S
T
F
L
L
H
D
PRPVSGLSILRTN
R
V
E
V
P
I
E
C
R
Y
P
R-----------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
67.46
30%
28
- C1 -
5AZ8
1
MALE_ECOLI (first)
A:
[5-373]
--------------------------------
E
G
K
L
V
--
I
W
I
N
G
D
-
K
-
G
--
Y
N
G
L
A
E
-
V
G
K
K
-----
F
E
K
D
T
G
I
K
V
T
V
E
H
P
D
K
L
E
--
E
K
F
P
Q
V
A
-
A
T
G
D
G
P
D
I
I
F
W
-
A
H
D
R
F
G
G
Y
A
Q
S
G
L
L
--
A
E
I
T
--
P
--
D
----------
K
--
A
F
Q
D
K
L
Y
P
F
T
W
D
A
V
R
-
Y
N
G
K
L
I
A
Y
P
I
A
V
E
A
L
S
L
I
Y
N
K
D
L
L
P
N
P
P
K
T
W
E
E
I
P
----
A
L
D
K
E
L
K
-----
A
K
G
K
S
-----
A
L
M
F
N
L
Q
E
P
Y
F
T
W
P
L
I
A
A
D
G
G
Y
-
A
F
K
Y
E
N
--
G
---
K
Y-
D
I
K
D
V
G
V
D
N
A
G
A
K
A
G
L
T
F
L
V
D
L
I
---------
K
N
K
H
M
N
A
D
T
D
Y
S
I
A
E
A
A
F
N
K
G
E
T
A
M
T
I
N
G
P
W
A
W
S
N
I
D
T
S
-
K
V
N
Y
G
V
T
V
L
P
T
F
-
K
G
Q
P
-
S
K
P
F
V
G
V
L
S
A
G
I
N
A
A
S
P
N
K
E
L
A
K
E
F
L
-
E
N
Y
-
L
L
T
D
E
G
L
E
A
V
N
K
D
K
---
P
L
G
A
V
A
L
K
S
-
Y
E
E
--
E
L
V
K
D
P
R
I
A
A
T
M
E
N
A
Q
K
G
E
I
M
P
N
I
P
Q
M
S
A
F
W
Y
A
V
R
T
A
V
I
N
A
A
S
G
R
Q
-
T
V
D
E
A
L
K
D
A
Q
T
R
I
K
E
A
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
65.86
24%
10
- C1 -
2VGQ
6
MALE_ECOLI (first)
A:
[17-477]
-------------------------------
I
E
E
G
K
L
--
V
I
W
I
N
G
-
D
-
K
--
G
Y
N
G
L
A
E
V
G
K
K
-----
F
E
K
D
T
G
I
K
V
T
V
E
H
P
D
--
K
L
E
E
K
F
P
Q
V
A
-
A
T
G
D
G
P
D
I
I
F
W
-
A
H
D
R
F
G
G
Y
A
Q
S
G
L
L
--
A
E
I
T
--
P
--
D
---
K
---
A
--
F
Q
D
K
L
Y
P
F
----
T
W
D
A
V
R
-
Y
N
G
K
L
I
A
Y
P
I
A
V
E
A
L
S
L
I
Y
N
K
D
L
L
P
N
P
P
K
T
W
E
E
I
P
----
A
L
D
K
E
L
K
A
------
K
G
K
S
----
A
L
M
F
N
L
Q
E
P
Y
F
T
W
P
L
I
A
A
D
G
G
Y
-
A
F
K
-
Y
E
--
N
GK-
Y
--
D
I
K
D
V
G
V
D
N
A
G
A
K
A
G
L
T
F
L
V
D
L
I
-
K
-------
N
K
H
M
N
A
D
T
D
Y
S
I
A
-
E
A
A
F
N
K
G
E
T
A
M
T
I
N
G
P
W
A
W
S
N
I
D
T
S
-
K
V
N
Y
G
V
T
V
L
P
T
-
F
K
G
Q
P
-
S
K
P
F
V
G
V
L
S
A
G
I
N
A
A
S
P
N
K
E
L
A
K
E
F
L
-
E
-
N
-
Y
L
L
T
D
E
G
L
E
A
V
N
K
D
K
P
L
G
A
V
A
L
K
S
Y
E
-
E
E
L
--
A
--
K
D
P
R
I
A
A
T
M
E
N
A
Q
K
G
E
I
M
P
N
I
P
Q
M
S
A
F
W
Y
A
V
R
T
A
V
I
N
A
A
S
G
R
Q
-
T
V
D
E
A
L
K
D
A
Q
T
N
S
A
M
A
F
A
E
-----
D
K
T
Y
K
Y
I
C
R
N
FSNFCNVDVVEILPYLPCLT
A
R
D
Q
D
R
L
R
A
T
C
T
L
SG
N
R
D
T
L
W
H
L
F
N
T
L
Q
R
RPG
W
V
E
Y
F
I
A
A
L
R
G
C
EL
V
D
L
A
D
E
V
A
S
V
Y
Q----------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
65.45
30%
20
- C1 -
2GHA
1
?
A:
[5-374]
---------------------------------------
L
T
I
W
C
S
-
E
-
K
--
Q
V
D
I
L
Q
K
L
G
E
E
-----
F
K
A
K
Y
G
V
E
V
E
-
V
Q
Y
V
N
F
Q
D
I
K
S
K
F
L
T
A
A
P
E
G
Q
G
A
D
I
I
V
G
-
A
H
D
W
V
G
E
L
A
V
N
G
-
L
--
I
E
P
I
--
P
N
F
S
---
D
---
L
--
K
--
N
F
Y
E
T
----
A
L
N
A
F
S
-
Y
G
G
K
L
Y
G
I
P
Y
A
M
E
A
I
A
L
I
Y
N
K
D
Y
V
P
E
P
P
K
T
M
D
E
L
I
----
E
I
A
K
Q
I
D
E
E
F
G
---
G
E
V
R
----
G
F
I
T
S
A
A
E
F
Y
Y
I
A
P
F
I
F
G
Y
G
G
Y
-
V
F
K
-
Q
T
EK
G
---
L
--
D
V
N
D
I
G
L
A
N
E
G
A
I
K
G
V
K
L
L
K
R
L
V
-
D
-------
E
G
I
L
D
P
S
D
N
Y
Q
I
M
-
D
S
M
F
R
E
G
Q
A
A
M
I
I
N
G
P
W
A
I
K
A
Y
K
D
A
-
G
I
D
Y
G
V
A
P
I
P
D
L
E
P
G
V
P
-
A
R
P
F
V
G
V
Q
G
F
M
V
N
A
K
S
P
N
K
L
L
A
I
E
F
L
T
S
-
F
-
I
A
K
K
E
T
M
Y
R
I
Y
L
G
D
P
R
L
P
----
S
R
K
D
-
V
L
E
L
V
K
--
D
N
P
D
V
V
G
F
T
L
S
A
A
N
G
I
P
M
P
N
V
P
Q
M
A
A
V
W
A
A
M
N
D
A
L
N
L
V
V
N
G
K
A
-
T
V
E
E
A
L
K
N
A
V
E
R
I
K
A
Q
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
65.40
26%
17
- C1 -
2GH9
1
?
A:
[2-379]
------------------------------------
K
--
I
T
V
W
T
H
-
F
G
G
P
-
E
L
E
W
L
K
E
Q
A
R
T
-----
F
E
R
T
S
G
T
K
V
E
V
V
E
V
P
F
A
E
I
K
Q
K
F
I
L
G
A
-
P
Q
G
Q
A
A
D
L
V
V
T
V
P
H
D
W
V
G
E
M
A
Q
A
G
V
L
--
E
P
V
G
--
K
--
Y
VT
Q
A
Y
--
L
--
A
--
D
L
Q
G
V
----
A
V
E
A
F
T
-
F
G
G
R
L
M
G
L
P
A
F
A
E
S
V
A
L
I
Y
N
K
K
Y
V
K
E
P
P
R
T
W
E
E
F
L
----
A
L
A
Q
K
L
T
T
-----
G
A
T
-
F
----
G
F
L
Y
N
I
G
D
P
Y
F
N
F
G
F
F
K
A
F
G
A
E
N
V
F
A
-
K
D
--
A
K
G
N
L
--
D
P
T
K
L
L
I
G
G
E
V
G
E
K
A
L
Q
F
I
K
D
L
R
-
F
KY
N
-
L
V
P
E
G
V
D
-----
Y
G
V
A
-
D
G
A
F
K
D
G
A
L
A
M
I
L
N
G
P
W
A
L
G
D
Y
K
K
A
-
K
V
D
F
G
I
A
P
F
P
V
P
P
G
A
K
N
P
W
G
P
F
L
G
V
Q
G
V
V
V
N
A
Y
S
K
N
K
T
Q
A
V
N
F
A
-
K
-
T
-
L
V
T
G
R
N
L
V
A
F
N
Q
A
G
G
R
I
P
V
S
K
S
A
V
K
Q
--
L
---
E
--
K
D
P
V
V
A
G
F
S
K
V
F
P
L
G
A
P
M
P
N
I
P
E
M
G
K
V
W
G
P
W
G
N
A
I
S
L
A
I
Q
R
P
D
S
N
V
K
K
I
V
E
D
M
V
A
E
I
K
K
A
I
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
64.21
30%
14
- C- -
2GHB
-
?
A:
[7-376]
---------------------------------------
L
T
I
W
C
S
-
E
-
K
--
Q
V
D
I
L
Q
K
L
G
E
E
-----
F
K
A
K
Y
G
V
E
V
E
-
V
Q
Y
V
N
F
Q
D
I
K
S
K
F
L
T
A
A
P
E
G
Q
G
A
D
I
I
V
G
-
A
H
D
W
V
G
E
L
A
V
N
G
-
L
--
I
E
P
I
--
P
N
F
S
---
D
---
L
--
K
--
N
F
Y
E
T
----
A
L
N
A
F
S
-
Y
G
G
K
L
Y
G
I
P
Y
A
M
E
A
I
A
L
I
Y
N
K
D
Y
V
P
E
P
P
K
T
M
D
E
L
I
----
E
I
A
K
Q
I
D
E
E
F
G
---
G
E
V
R
----
G
F
I
T
S
A
A
E
F
Y
Y
I
A
P
F
I
F
G
Y
G
G
Y
-
V
F
K
-
Q
T
EK
G
---
L
--
D
V
N
D
I
G
L
A
N
E
G
A
I
K
G
V
K
L
L
K
R
L
V
-
D
-------
E
G
I
L
D
P
S
D
N
Y
Q
I
M
-
D
S
M
F
R
E
G
Q
A
A
M
I
I
N
G
P
W
A
I
K
A
Y
K
D
A
-
G
I
D
Y
G
V
A
P
I
P
D
L
E
P
G
V
P
-
A
R
P
F
V
G
V
Q
G
F
M
V
N
A
K
S
P
N
K
L
L
A
I
E
F
L
T
S
-
F
-
I
A
K
K
E
T
M
Y
R
I
Y
L
G
D
P
R
L
P
----
S
R
K
D
-
V
L
E
L
V
K
--
D
N
P
D
V
V
G
F
T
L
S
A
A
N
G
I
P
M
P
N
V
P
Q
M
A
A
V
W
A
A
M
N
D
A
L
N
L
V
V
N
G
K
A
-
T
V
E
E
A
L
K
N
A
V
E
R
I
K
A
Q
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Fugue
64.18
23%
17
- C1 -
1Y4C
1
MALE_ECOLI
A:
[4-493]
---------------------------------
E
G
K
L
--
V
I
W
I
N
G
-
D
-
K
--
G
Y
N
G
L
A
E
V
G
K
K
-----
F
E
K
D
T
G
I
K
V
T
V
E
H
P
D
--
K
L
E
E
K
F
P
Q
V
A
-
A
T
G
D
G
P
D
I
I
F
W
-
A
H
D
R
F
G
G
Y
A
Q
S
G
L
L
--
A
E
I
T
P
D
K
--
A
---
F
---
Q
--
D
--
K
L
Y
P
F
----
T
W
D
A
V
R
-
Y
N
G
K
L
I
A
Y
P
I
A
V
E
A
L
S
L
I
Y
N
K
D
L
L
P
N
P
P
K
T
W
E
E
I
P
----
A
L
D
K
E
L
K
------
A
K
G
K
S
----
A
L
M
F
N
L
Q
E
P
Y
F
T
W
P
L
I
A
A
D
G
G
Y
-
A
F
K
-
Y
E
--
N
GK-
Y
--
D
I
K
D
V
G
V
D
N
A
G
A
K
A
G
L
T
F
L
V
D
L
I
-
K
-------
N
K
H
M
N
A
D
T
D
Y
S
I
A
-
E
A
A
F
N
K
G
E
T
A
M
T
I
N
G
P
W
A
W
S
N
I
D
T
S
-
K
V
N
Y
G
V
T
V
L
P
T
-
F
K
G
Q
P
-
S
K
P
F
V
G
V
L
S
A
G
I
N
A
A
S
P
N
K
E
L
A
K
E
F
L
-
E
-
N
-
Y
L
L
T
D
E
G
L
E
A
V
N
K
D
K
P
L
G
A
V
A
L
K
S
Y
E
-
E
E
L
--
A
--
K
D
P
R
I
A
A
T
M
E
N
A
Q
K
G
E
I
M
P
N
I
P
Q
M
S
A
F
W
Y
A
V
R
T
A
V
I
N
A
A
S
G
R
Q
-
T
V
D
E
A
L
K
D
A
Q
T
N
S
S
S
L
G
I
E
-----
G
R
S
S
E
E
L
L
K
I
A
L
Q
E
A
Q
K
T
L
Q
Q
A
Q
E
L
A
K
KGGG
E
E
Q
L
K
R
A
L
K
R
A
D
R
N
L
W
A
A
Q
E
L
A
K
K
GGGGE
E
L
L
K
Q
A
L
Q
Q
A
Q
Q
L
L
R
Q
A
Q
E
L
A
K
K
GGG
E
E
L
L
K
Q
A
L
Q
Q
A
Q
Q
L
L
Q
Q
A
Q
E
L
AK-------------------------------------------------------------------------------------
25
HHSearch
63.51
31%
53
- C1 -
2ZYO
1
?
A:
[15-394]
-------------------------------
E
G
K
P
D
K
--
L
V
V
W
E
N
-
A
D
D
G
V
Q
L
N
N
T
K
K
W
A
G
E
-----
F
T
K
K
T
G
I
Q
V
E
V
V
P
V
A
L
L
K
Q
Q
E
K
L
T
L
D
G
-
P
A
G
K
G
A
D
L
V
T
W
-
P
H
D
R
L
G
E
A
V
T
K
G
L
L
--
Q
P
I
Q
--
V
--
D
---
N
S
V
-
K
--
N
--
Q
F
D
D
V
----
A
M
K
A
L
T
-
Y
G
G
K
L
Y
G
L
P
K
A
I
E
S
V
A
L
I
Y
N
K
K
L
M
G
Q
V
P
A
T
Y
D
E
L
F
----
Q
Y
A
K
A
N
N
K
P
D
---
E
Q
K
-
Y
----
G
V
L
F
E
A
N
N
F
Y
Y
T
Y
F
L
F
A
A
K
G
A
A
-
V
F
K
-
E
Q
--
D
GT-
L
--
D
P
N
E
I
G
L
N
S
P
E
A
V
Q
G
M
N
E
V
Q
K
W
F
-
T
E-
A
-
R
L
P
Q
S
L
K
-----
A
D
T
V
-
N
G
L
F
K
S
G
K
V
A
A
V
I
N
G
P
W
A
I
K
D
Y
Q
A
A
-
G
I
N
V
G
V
A
P
L
P
K
I
D
G
K
D
--
A
Q
T
F
I
G
V
K
G
W
Y
L
S
A
Y
S
K
Y
P
K
Y
A
T
E
L
M
-
Q
-
F
-
L
T
S
K
E
A
L
A
S
R
F
K
E
T
G
E
I
P
P
Q
K
E
L
L
N
D
P
M
I
---
K
--
N
N
P
V
V
N
G
F
A
K
Q
A
S
K
G
V
P
M
P
S
I
P
E
M
G
V
V
W
E
P
I
N
N
A
H
T
F
V
A
Q
G
K
Q
-
T
P
E
Q
A
L
N
D
A
V
K
I
M
K
E
K
I
Q
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
63.43
31%
51
- C1 -
2ZYK
1
?
D:
[17-393]
-----------------------------------
K
P
--
D
K
L
V
V
W
-
E
-
N
--
A
D
D
G
V
Q
L
N
N
T
K
KWAGE
F
T
K
K
T
G
I
Q
V
E
V
V
P
V
A
L
L
K
Q
Q
E
K
L
T
L
D
G
-
P
A
G
K
G
A
D
L
V
T
W
-
P
H
D
R
L
G
E
A
V
T
K
G
L
L
--
Q
P
I
Q
--
V
--
D
---
N
---
S
VK
N
--
Q
F
D
D
V
----
A
M
K
A
L
T
-
Y
G
G
K
L
Y
G
L
P
K
A
I
E
S
V
A
L
I
Y
N
K
K
L
M
G
Q
V
P
A
T
Y
D
E
L
------------
F
Q
Y
A
K
A
N
N
K
P
D
EQKY
G
V
L
F
E
A
N
N
F
Y
Y
T
Y
F
L
F
A
A
K
G
A
A
-
V
F
K
E
Q
D
--
G
---
T
L-
D
P
N
E
I
G
L
N
S
P
E
A
V
Q
G
M
N
E
V
Q
K
W
F
T
E
--
A
-
R
L
P
Q
S
L
K
A
-----
D
T
V
-
N
G
L
F
K
S
G
K
V
A
A
V
I
N
G
P
W
A
I
K
D
Y
Q
A
A
-
G
I
N
V
G
V
A
P
L
P
K
I
-
D
G
K
D
-
A
Q
T
F
I
G
V
K
G
W
Y
L
S
A
Y
S
K
Y
P
K
Y
A
T
E
L
M
-
Q
-
F
-
L
T
S
K
E
A
L
A
S
R
F
K
E
T
G
E
I
P
P
Q
K
E
L
L
N
D
-
P
M
I
--
K
--
N
N
P
V
V
N
G
F
A
K
Q
A
S
K
G
V
P
M
P
S
I
P
E
M
G
V
V
W
E
P
I
N
N
A
H
T
F
V
A
Q
G
K
Q
-
T
P
E
Q
A
L
N
D
A
V
K
I
M
K
E
K
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
62.59
29%
31
- C1 -
4B3N
1
MALE_ECOLI
A:
[19-413]
---------------------------------
G
K
L
V
--
I
W
I
N
G
D
-
K
-
G
--
Y
N
G
L
A
E
-
V
G
K
K
-----
F
E
K
D
T
G
I
K
V
T
V
E
H
P
D
K
L
E
--
E
K
F
P
Q
V
A
-
A
T
G
D
G
P
D
I
I
F
W
-
A
H
D
R
F
G
G
Y
A
Q
S
G
L
L
--
A
E
I
T
--
P
--
D
----------
K
--
A
F
Q
D
K
L
Y
P
F
T
W
D
A
V
R
-
Y
N
G
K
L
I
A
Y
P
I
A
V
E
A
L
S
L
I
Y
N
K
D
L
L
P
N
P
P
K
T
W
E
E
I
P
----
A
L
D
K
E
L
K
-----
A
K
G
K
S
-----
A
L
M
F
N
L
Q
E
P
Y
F
T
W
P
L
I
A
A
D
G
G
Y
-
A
F
K
Y
E
N
--
G
---
K
Y-
D
I
K
D
V
G
V
D
N
A
G
A
K
A
G
L
T
F
L
V
D
L
I
---------
K
N
K
H
M
N
A
D
T
D
Y
S
I
A
E
A
A
F
N
K
G
E
T
A
M
T
I
N
G
P
W
A
W
S
N
I
D
T
S
-
K
V
N
Y
G
V
T
V
L
P
T
F
-
K
G
Q
P
-
S
K
P
F
V
G
V
L
S
A
G
I
D
A
A
S
P
N
K
E
L
A
K
E
F
L
-
E
N
Y
-
L
L
T
D
E
G
L
E
A
V
N
K
D
K
---
P
L
G
A
V
A
L
K
S
-
Y
E
E
--
E
L
A
K
D
P
R
I
A
A
T
M
E
N
A
Q
K
G
E
I
M
P
N
I
P
Q
M
S
A
F
W
Y
A
V
R
T
A
V
I
N
A
A
S
G
R
Q
-
T
V
D
E
A
L
K
D
A
Q
T
R
I
T
R
R
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
61.98
31%
50
- C1 -
2ZYK
1
?
A:
[17-393]
-----------------------------------
K
P
--
D
K
L
V
V
W
-
E
-
N
--
A
D
D
G
V
Q
L
N
N
T
K
K
W
A
G
E
F
T
K
K
T
G
I
Q
V
E
V
V
P
V
A
L
L
K
Q
Q
E
K
L
T
L
D
G
-
P
A
G
K
G
A
D
L
V
T
W
-
P
H
D
R
L
G
E
A
V
T
K
G
L
L
--
Q
P
I
Q
--
V
--
D
---
N
---
S
V
K
N
--
Q
F
D
D
V
----
A
M
K
A
L
T
-
Y
G
G
K
L
Y
G
L
P
K
A
I
E
S
V
A
L
I
Y
N
K
K
L
M
G
Q
V
P
A
T
Y
D
E
L
------------
F
Q
Y
A
K
A
N
N
K
P
D
EQKY
G
V
L
F
E
A
N
N
F
Y
Y
T
Y
F
L
F
A
A
K
G
A
A
-
V
F
K
E
Q
D
--
G
---
T
L-
D
P
N
E
I
G
L
N
S
P
E
A
V
Q
G
M
N
E
V
Q
K
W
F
T
E
--
A
-
R
L
P
Q
S
L
K
A
-----
D
T
V
-
N
G
L
F
K
S
G
K
V
A
A
V
I
N
G
P
W
A
I
K
D
Y
Q
A
A
-
G
I
N
V
G
V
A
P
L
P
K
I
-
D
G
K
D
-
A
Q
T
F
I
G
V
K
G
W
Y
L
S
A
Y
S
K
Y
P
K
Y
A
T
E
L
M
-
Q
-
F
-
L
T
S
K
E
A
L
A
S
R
F
K
E
T
G
E
I
P
P
Q
K
E
L
L
N
D
-
P
M
I
--
K
--
N
N
P
V
V
N
G
F
A
K
Q
A
S
K
G
V
P
M
P
S
I
P
E
M
G
V
V
W
E
P
I
N
N
A
H
T
F
V
A
Q
G
K
Q
-
T
P
E
Q
A
L
N
D
A
V
K
I
M
K
E
K
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
61.79
23%
14
- C1 -
3MP6
2
MALE_ECOLI (first)
A:
[1-517]
-----------------------------
M
K
I
E
E
G
K
L
--
V
I
W
I
N
G
-
D
-
K
--
G
Y
N
G
L
A
E
V
G
K
K
-----
F
E
K
D
T
G
I
K
V
T
V
E
H
P
D
--
K
L
E
E
K
F
P
Q
V
A
-
A
T
G
D
G
P
D
I
I
F
W
-
A
H
D
R
F
G
G
Y
A
Q
S
G
L
L
A
E
I
T
P
D
--
K
--
A
---
F
---
Q
--
D
--
K
L
Y
P
F
----
T
W
D
A
V
R
-
Y
N
G
K
L
I
A
Y
P
I
A
V
E
A
L
S
L
I
Y
N
K
D
L
L
P
N
P
P
K
T
W
E
E
I
P
----
A
L
D
K
E
L
K
------
A
K
G
K
S
----
A
L
M
F
N
L
Q
E
P
Y
F
T
W
P
L
I
A
A
D
G
G
Y
-
A
F
K
-
Y
E
--
N
GK-
Y
--
D
I
K
D
V
G
V
D
N
A
G
A
K
A
G
L
T
F
L
V
D
L
I
-
K
-------
N
K
H
M
N
A
D
T
D
Y
S
I
A
-
E
A
A
F
N
K
G
E
T
A
M
T
I
N
G
P
W
A
W
S
N
I
D
T
S
-
K
V
N
Y
G
V
T
V
L
P
T
F
-
K
G
Q
P
-
S
K
P
F
V
G
V
L
S
A
G
I
N
A
A
S
P
N
K
E
L
A
K
E
F
L
-
E
-
N
-
Y
L
L
T
D
E
G
L
E
A
V
N
K
D
K
P
L
G
A
V
A
L
K
S
Y
E
-
E
E
L
--
A
--
K
D
P
R
I
A
A
T
M
E
N
A
Q
K
G
E
I
M
P
N
I
P
Q
M
S
A
F
W
Y
A
V
R
T
A
V
I
N
A
A
S
G
R
Q
-
T
V
D
E
A
L
A
A
A
Q
T
N
A
A
A
E
F
G
S
-----
S
Y
W
T
SEYNPNAPILVG
S
E
V
A
Y
K
P
RG
E
W
I
Q
C
E
V
LKVVADGT
R
F
E
V
R
DPEPDELGNS
G
K
V
Y
K
C
N
RKELLLIPPGFPTKNYPPG
T
K
V
L
A
R
Y
P
ETT
T
F
Y
P
A
I
V
IGTKRDG
T
C
R
L
R
F
D
GEK
E
T
E
V
T
RRL
V
L
P
S
PTALA-------------------------------------------------------------
23
PsiBlast_CBE
60.87
31%
52
- C1 -
2ZYK
1
?
B:
[17-393]
-----------------------------------
K
P
--
D
K
L
V
V
W
-
E
-
N
--
A
D
D
G
V
Q
L
N
N
T
K
KWAGE
F
T
K
K
T
G
I
Q
V
E
V
V
P
V
A
L
L
K
Q
Q
E
K
L
T
L
D
G
-
P
A
G
K
G
A
D
L
V
T
W
-
P
H
D
R
L
G
E
A
V
T
K
G
L
L
--
Q
P
I
Q
--
V
--
D
---
N
---
S
VK
N
--
Q
F
D
D
V
----
A
M
K
A
L
T
-
Y
G
G
K
L
Y
G
L
P
K
A
I
E
S
V
A
L
I
Y
N
K
K
L
M
G
Q
V
P
A
T
Y
D
E
L
------------
F
Q
Y
A
K
A
N
N
K
P
D
EQKY
G
V
L
F
E
A
N
N
F
Y
Y
T
Y
F
L
F
A
A
K
G
A
A
-
V
F
K
E
Q
D
--
G
---
T
L-
D
P
N
E
I
G
L
N
S
P
E
A
V
Q
G
M
N
E
V
Q
K
W
F
T
E
--
A
-
R
L
P
Q
S
L
K
A
-----
D
T
V
-
N
G
L
F
K
S
G
K
V
A
A
V
I
N
G
P
W
A
I
K
D
Y
Q
A
A
-
G
I
N
V
G
V
A
P
L
P
K
I
-
D
G
K
D
-
A
Q
T
F
I
G
V
K
G
W
Y
L
S
A
Y
S
K
Y
P
K
Y
A
T
E
L
M
-
Q
-
F
-
L
T
S
K
E
A
L
A
S
R
F
K
E
T
G
E
I
P
P
Q
K
E
L
L
N
D
-
P
M
I
--
K
--
N
N
P
V
V
N
G
F
A
K
Q
A
S
K
G
V
P
M
P
S
I
P
E
M
G
V
V
W
E
P
I
N
N
A
H
T
F
V
A
Q
G
K
Q
-
T
P
E
Q
A
L
N
D
A
V
K
I
M
K
E
K
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
59.63
23%
13
- C1 -
3H4Z
2
ALL7_DERPT (first)
A:
[1-568]
------------------------------
K
I
E
E
G
K
L
--
V
I
W
I
N
G
-
D
-
K
--
G
Y
N
G
L
A
E
V
G
K
K
-----
F
E
K
D
T
G
I
K
V
T
V
E
H
P
D
--
K
L
E
E
K
F
P
Q
V
A
-
A
T
G
D
G
P
D
I
I
F
W
-
A
H
D
R
F
G
G
Y
A
Q
S
G
L
L
--
A
E
I
T
--
P
--
A
---
A
---
A
--
F
Q
D
K
L
Y
P
F
----
T
W
D
A
V
R
-
Y
N
G
K
L
I
A
Y
P
I
A
V
E
A
L
S
L
I
Y
N
K
D
L
L
P
N
P
P
K
T
W
E
E
I
P
----
A
L
D
K
E
L
K
------
A
K
G
K
S
----
A
L
M
F
N
L
Q
E
P
Y
F
T
W
P
L
I
A
A
D
G
G
Y
-
A
F
K
-
Y
A
--
A
GK-
Y
--
D
I
K
D
V
G
V
D
N
A
G
A
K
A
G
L
T
F
L
V
D
L
I
-
K
-------
N
K
H
M
N
A
D
T
D
Y
S
I
A
-
E
A
A
F
N
K
G
E
T
A
M
T
I
N
G
P
W
A
W
S
N
I
D
T
S
-
A
V
N
Y
G
V
T
V
L
P
T
F
-
K
G
Q
P
-
S
K
P
F
V
G
V
L
S
A
G
I
N
A
A
S
P
N
K
E
L
A
K
E
F
L
-
E
-
N
-
Y
L
L
T
D
E
G
L
E
A
V
N
K
D
K
P
L
G
A
V
A
L
K
S
Y
E
-
E
E
L
--
A
--
K
D
P
R
I
A
A
T
M
E
N
A
Q
K
G
E
I
M
P
N
I
P
Q
M
S
A
F
W
Y
A
V
R
T
A
V
I
N
A
A
S
G
R
Q
-
T
V
D
A
A
L
A
A
A
Q
T
N
A
A
A
D
P
I
H
-----
Y
D
K
I
T
E
E
I
N
K
A
V
D
E
A
V
A
A
I
E
K
S
ETFDP
M
K
V
P
D
H
S
D
K
F
E
R
HIGIID
L
K
G
E
L
D
M
R
N
I
Q
V
R
GLKQMKRVGDAN
V
K
S
E
DG
V
V
K
A
H
L
L
V
G
V
H
D
D
V
V
S
M
E
Y
D
L
A
Y
K
L
GD
L
H
P
N
T
H
V
I
S
D
I
Q
D
F
V
V
E
L
S
L
E
V
S
EEG
N
M
T
L
TSFEVRQFA
N
V
V
N
H
I
G
GLSILDPI
F
A
V
L
S
D
V
L
T
A
I
F
Q
D
T
V
R
A
E
M
T
K
V
L
A
P
A
F
K
K
E
L
E
RNNQ
22
PsiBlast_CBE
59.50
31%
50
- C1 -
2ZYK
1
?
C:
[17-393]
-----------------------------------
K
P
--
D
K
L
V
V
W
-
E
-
N
--
A
D
D
G
V
Q
L
N
N
T
K
KWAGE
F
T
K
K
T
G
I
Q
V
E
V
V
P
V
A
L
L
K
Q
Q
E
K
L
T
L
D
G
-
P
A
G
K
G
A
D
L
V
T
W
-
P
H
D
R
L
G
E
A
V
T
K
G
L
L
--
Q
P
I
Q
--
V
--
D
---
N
---
S
VK
N
--
Q
F
D
D
V
----
A
M
K
A
L
T
-
Y
G
G
K
L
Y
G
L
P
K
A
I
E
S
V
A
L
I
Y
N
K
K
L
M
G
Q
V
P
A
T
Y
D
E
L
------------
F
Q
Y
A
K
A
N
N
K
P
D
EQKY
G
V
L
F
E
A
N
N
F
Y
Y
T
Y
F
L
F
A
A
K
G
A
A
-
V
F
K
E
Q
D
--
G
---
T
L-
D
P
N
E
I
G
L
N
S
P
E
A
V
Q
G
M
N
E
V
Q
K
W
F
T
E
--
A
-
R
L
P
Q
S
L
K
A
-----
D
T
V
-
N
G
L
F
K
S
G
K
V
A
A
V
I
N
G
P
W
A
I
K
D
Y
Q
A
A
-
G
I
N
V
G
V
A
P
L
P
K
I
-
D
G
K
D
-
A
Q
T
F
I
G
V
K
G
W
Y
L
S
A
Y
S
K
Y
P
K
Y
A
T
E
L
M
-
Q
-
F
-
L
T
S
K
E
A
L
A
S
R
F
K
E
T
G
E
I
P
P
Q
K
E
L
L
N
D
-
P
M
I
--
K
--
N
N
P
V
V
N
G
F
A
K
Q
A
S
K
G
V
P
M
P
S
I
P
E
M
G
V
V
W
E
P
I
N
N
A
H
T
F
V
A
Q
G
K
Q
-
T
P
E
Q
A
L
N
D
A
V
K
I
M
K
E
K
I
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
46.97
31%
59
- C1 -
4HW8
13
?
A:
[37-411]
-------------------------------
K
D
K
P
N
Q
--
L
T
M
W
V
D
-
G
D
K
--
Q
M
A
F
Y
K
K
I
T
D
Q
-----
Y
T
K
K
T
G
I
K
V
K
L
V
N
I
G
Q
N
D
Q
L
E
N
I
S
L
D
A
-
P
A
G
K
G
P
D
I
F
F
L
-
A
H
D
N
T
G
S
A
Y
L
Q
G
L
A
--
A
E
I
K
--
L
--
S
K--
D
E--
L
--
K
--
G
F
N
K
Q
----
A
L
K
A
M
N
-
Y
D
N
K
Q
L
A
L
P
A
I
V
E
T
T
A
L
F
Y
N
K
K
L
V
K
N
A
P
Q
T
L
E
E
V
E
----
A
N
A
A
K
L
T
D
S
K
---
K
K
Q
-
Y
----
G
M
L
F
D
A
K
N
F
Y
F
N
Y
P
F
L
F
G
N
D
D
Y
-
I
F
K
-
K
N
--
G
---
S
EY
D
I
H
Q
L
G
L
N
S
K
H
V
V
K
N
A
E
R
L
Q
K
W
Y
-
D
K
-
G
-
Y
L
P
K
A
A
T
-----
H
D
V
M
-
I
G
L
F
K
E
G
K
V
G
Q
F
V
T
G
P
W
N
I
N
E
Y
Q
E
T
F
G
K
D
L
G
V
T
T
L
P
T
D
G
G
K
-
P
-
M
K
P
F
L
G
V
R
G
W
Y
L
S
E
Y
S
K
H
K
Y
W
A
K
D
L
M
-
L
-
Y
-
I
T
S
K
D
T
L
Q
K
Y
T
D
E
M
S
E
I
T
G
R
V
D
V
K
S
S
----------
N
P
N
L
K
V
F
E
K
Q
A
R
H
A
E
P
M
P
N
I
P
E
M
R
Q
V
W
E
P
M
G
N
A
S
I
-
F
I
S
N
G
K
-
N
P
K
Q
A
L
D
E
A
T
N
D
I
T
Q
N
I
K
I
-----
L
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
46.06
30%
62
- C1 -
4HW8
13
?
A:
[37-408]
-------------------------------
K
D
K
P
N
Q
--
L
T
M
W
V
D
G
D
-
K
--
Q
M
A
F
Y
K
K
I
T
D
Q
-----
Y
T
K
K
T
G
I
K
V
K
L
V
N
I
G
Q
N
D
Q
L
E
N
I
S
L
D
A
-
P
A
G
K
G
P
D
I
F
F
L
-
A
H
D
N
T
G
S
A
Y
L
Q
G
L
A
--
A
E
I
K
--
L
--
S
---
K
DE-
L
--
K
--
G
F
N
K
Q
----
A
L
K
A
M
N
-
Y
D
N
K
Q
L
A
L
P
A
I
V
E
T
T
A
L
F
Y
N
K
K
L
V
K
N
A
P
Q
T
L
E
E
V
E
A
N
A
A
K
L
T
D
--------
S
K
K
K
Q
Y
----
G
M
L
F
D
A
K
N
F
Y
F
N
Y
P
F
L
F
G
N
D
D
Y
-
I
F
K
-
K
N
--
G
---
S
EY
D
I
H
Q
L
G
L
N
S
K
H
V
V
K
N
A
E
R
L
Q
K
W
Y
-
D
--
K
G
Y
L
P
K
-----
A
A
T
H
D
V
M
-
I
G
L
F
K
E
G
K
V
G
Q
F
V
T
G
P
W
N
I
N
E
Y
Q
E
T
F
G
K
D
L
G
V
T
T
L
P
T
-
D
G
G
K
P
-
M
K
P
F
L
G
V
R
G
W
Y
L
S
E
Y
S
K
H
K
Y
W
A
K
D
L
M
-
L
-
Y
-
I
T
S
K
D
T
L
Q
K
Y
T
D
E
M
S
E
I
T
G
R
V
D
V
K
--------
S
--
S
N
P
N
L
K
V
F
E
K
Q
A
R
H
A
E
P
M
P
N
I
P
E
M
R
Q
V
W
E
P
M
G
N
A
S
I
F
I
S
N
G
K
N
-
P
K
Q
-
A
L
D
E
A
T
N
D
I
T
Q
N
I
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------