@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu34820: (2016-07-29 )
MPTKKQKSKSKLKPFFALVRRTNPSYGKLAFALALSVVTTLVSLLIPLLTKQLVDGFSMSNLSGTQIGLIALVFFVQAGLSAYATYALNYNGQKIISGLRELLWKKLIKLPVSYFDTNASGETVSRVTNDTMVVKELITTHISGFITGIISVIGSLTILFIMNWKLTLLVLVVVPLAALILVPIGRKMFSISRETQDETARFTGLLNQILPEIRLVKASNAEDVEYGRGKMGISSLFKLGVREAKVQSLVGPLISLVLMAALVAVIGYGGMQVSSGELTAGALVAFILYLFQIIMPMGQITTFFTQLQKSIGATERMIEILAEEEEDTVTGKQIENAHLPIQLDRVSFGYKPDQLILKEVSAVIEAGKVTAIVGPSGGGKTTLFKLLERFYSPTAGTIRLGDEPVDTYSLESWREHIGYVSQESPLMSGTIRENICYGLERDVTDAEIEKAAEMAYALNFIKELPNQFDTEVGERGIMLSGGQRQRIAIARALLRNPSILMLDEATSSLDSQSEKSVQQALEVLMEGRTTIVIAHRLSTVVDADQLLFVEKGEITGRGTHHELMASHGLYRDFAEQQLKMNADLENKAG
Atome Classification :
(20 SA)
.........10........20.......-.30........40........50.....-.-..60----------------------.---------------------.-..-..-..70........80..-..-....90........100.......110.......120.......130.......140.......150--.........160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320..---.....330--........340.......350.-.--...-....360.......370.......380.......390.......400.......410.......420.......430.......440........450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPT
K
K
Q
K
S
K
S
K
L
K
P
F
F
A
L
V
RRTNPSY
G
K
-
L
A
F
A
L
A
L
S
V
V
T
T
L
V
S
L
L
I
P
L
L
T
K
Q
L
V
DG-F-SMSN----------------------L---------------------S-G
T
-
Q
I
-
G
L
I
A
L
V
F
F
V
Q
A
G
L
S
A
Y
-
A
T
-
Y
A
LNYN
G
Q
K
I
I
S
G
L
R
E
L
L
W
K
K
L
I
KL
P
V
S
YFDTNASGE
T
V
S
R
VTN
D
T
M
V
V
K
E
L
I
T
T
H
I
S
G
F
I
T
G
I
I
----
S
V
I
G
S
L
T
I
L
F
I
MNW
K
L
T
L
L
V
L
V
V
V
P
L
A
A
L
I
L
V
PI
G
R
K
M
F
S
ISRET
Q
D
E
T
A
R
F
T
G
L
L
N
Q
I
L
P
E
I
R
L
V
KASNAEDVEYGRGKM
G
I
S
S
L
F
K
LG
V
R
E
A
K
V
Q
S
L
V
G
P
L
I
S
L
V
L
M
A
A
L
V
A
V
IGYGG
M
Q
VSSGEL
T
A
G
A
L
V
A
F
I
L
Y
L
F
Q
I
I
MP
M
G
Q
I
T
T
F
F
T
Q
L
Q
K
SIG
A
T
E
R
M
I
E
I
L
AEE---EEDTVTG---KQIENAHL
P
I
Q
L
D
RVSFGY--K-
P
--
D
Q
L
-
I
L
K
E
V
S
A
V
I
EAG
K
V
T
A
I
V
GPSGG
G
K
T
T
L
F
K
L
L
E
R
F
YSPTA
G
T
I
R
LGDEPVDTY
S
L
E
S
W
R
E
HIGYVSQESPLMS
G
T
I
R
E
N
I
C
YGLER-DV
T
D
A
E
I
E
K
A
A
E
M
A
Y
A
L
N
F
I
K
EL
P
N
Q
F
D
T
E
VGER
G
I
M
LSGGQ
R
Q
R
I
A
I
A
R
A
L
LRNP
S
I
L
M
LDEATSSLD
S
Q
S
E
K
S
V
Q
Q
A
L
E
V
L
MEG
R
T
T
I
V
I
A
H
R
L
S
T
VVDA
D
Q
L
L
F
V
EKGEITGRG
T
H
H
E
L
M
A
SH
G
L
Y
R
D
F
A
E
Q
Q
L
KMNADLENKAG
127
HHSearch
92.19
31%
0
- C- -
4F4C
1
PGP1_CAEEL
A:
[65-700]
-----------------
L
Y
R
Y
T
T
T
L
E
K
L
L
L
F
I
G
T
L
V
A
V
I
T
G
A
G
L
P
L
M
S
I
L
Q
G
K
V
S
Q
A
-
F
I
N
E
Q
I
V
I
N
N
N
G
S
T
F
LPTGQNYT
K
T
D
F
E
H
---------------------
D
V
M
N
-
V
V
-
W
S
Y
A
A
M
T
V
G
M
W
A
A
G
Q
I
-
T
V
-
T
C
Y
L
Y
V
A
E
Q
M
N
N
R
L
R
R
E
F
V
K
S
I
L
R
Q
E
I
S
W
F
D
T
N
H
S
G
T
L
A
T
K
L
F
D
N
L
E
R
V
K
E
G
T
G
D
K
I
G
M
A
F
Q
Y
L
S
----
Q
F
I
T
G
F
I
V
A
F
T
H
S
W
Q
L
T
L
V
M
L
A
V
T
P
I
Q
A
L
C
G
F
A
I
A
K
S
M
S
T
F
A
I
R
E
T
L
R
Y
A
K
A
G
K
V
V
E
E
T
I
S
S
I
R
T
V
V
S
L
N
G
L
R
Y
E
L
E
R
Y
S
T
A
V
E
E
A
K
K
A
G
V
L
K
G
L
F
L
G
I
S
F
G
A
M
Q
A
S
N
F
I
S
F
A
L
A
F
Y
I
G
V
G
W
V
H
D
G
S
L
N
F
G
D
M
L
T
T
F
S
S
V
M
M
G
S
M
A
L
G
L
A
G
P
Q
L
A
V
L
G
T
A
Q
G
A
A
S
G
I
Y
E
V
L
D
R
K
---
P
V
I
D
S
S
S
K
A
G
R
K
D
M
K
I
K
G
D
I
T
V
E
N
V
H
F
T
Y
--
P
-
S
RP
D
V
P
-
I
L
R
G
M
N
L
R
V
N
A
G
Q
T
V
A
L
V
G
S
S
G
C
G
K
S
T
I
I
S
L
L
L
R
Y
Y
D
V
L
K
G
K
I
T
I
D
G
V
D
V
R
D
I
N
L
E
F
L
R
K
N
V
A
V
V
S
Q
E
P
A
L
F
N
C
T
I
E
E
N
I
S
L
G
K
E
G
-
I
T
-
R
E
E
M
V
A
A
C
K
M
A
N
A
E
K
F
I
K
T
L
P
N
G
Y
N
T
L
V
G
D
R
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
S
E
G
I
V
Q
Q
A
L
D
K
A
A
K
G
R
T
T
I
I
I
A
H
R
L
S
T
I
R
N
A
D
L
I
I
S
C
K
N
G
Q
V
V
E
V
G
D
H
R
A
L
M
A
Q
Q
G
L
Y
Y
D
L
V
---------------
126
HHSearch
90.96
31%
0
- C- -
4Q9H
-
MDR1A_MOUSE
A:
[50-687]
-----------------------------
M
L
V
G
T
L
A
A
I
I
H
G
V
A
L
P
L
M
M
L
I
F
G
D
M
T
D
S
F
A
-
S
V
G
Q
----------------------
V
S
K
Q
S
TQMS
E
A
D
K
R
A
M
F
A
K
L
E
E
E
M
T
T
-
Y
A
-
Y
Y
Y
T
G
I
G
A
G
V
L
I
V
A
Y
I
-
Q
V
-
S
F
W
C
L
A
A
G
R
Q
I
H
K
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
F
D
V
H
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
I
G
M
F
F
Q
A
M
A
----
T
F
F
G
G
F
I
I
G
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
L
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
K
E
L
E
R
Y
N
N
N
L
E
E
A
K
R
L
G
I
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
L
I
Y
A
S
Y
A
L
A
F
W
Y
G
T
S
L
V
I
S
K
E
Y
S
I
G
Q
V
L
T
V
F
F
S
V
L
I
G
A
F
S
V
G
Q
A
S
P
N
I
E
A
F
A
N
A
R
G
A
A
Y
E
V
F
K
I
I
D
N
K
---
P
S
I
D
S
F
S
KSG
H
K
P
D
N
I
Q
G
N
L
E
F
K
N
I
H
F
S
Y
--
P
-
S
RK
E
V
Q
-
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
R
E
D
-
V
T
-
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
P
H
Q
F
D
T
L
V
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
E
G
R
T
T
I
V
I
A
H
R
L
S
T
V
R
N
A
D
V
I
A
G
F
D
G
G
V
I
V
E
Q
G
N
H
D
E
L
M
R
E
K
G
I
Y
F
K
L
V
M
T
Q
------------
26
PsiBlast_CBE
86.93
33%
-
- C1 -
3B5Z
2
MSBA_SALTY
D:
[32-580]
-----------------------------
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
----
D
G
-
F
-
G
K
T
D
----------------------
R
---------------------
S
-
V
L
L
W
M
-
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
-
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
----
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
REGA
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
---
Q
E
K
D
E
G
K
---
R
V
I
D
R
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
--
P
-
G
--
R
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
R
T
E
-
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
Y
A
Q
L
H
K
M
Q
F
-----------
9
PsiBlast_PDB
86.93
33%
-
- C1 -
3B5Z
2
MSBA_SALTY
A:
[32-580]
-----------------------------
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
----
D
G
-
F
-
G
K
T
D
----------------------
R
---------------------
S
-
V
L
L
W
M
-
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
-
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
----
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
EG
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
---
Q
E
K
D
E
G
K
---
R
V
I
D
R
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
--
P
-
G
--
R
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
R
T
E
-
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
Y
A
Q
L
H
K
M
Q
F
-----------
27
PsiBlast_CBE
86.92
33%
-
- C1 -
3B5Z
2
MSBA_SALTY
C:
[32-580]
-----------------------------
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
----
D
G
-
F
-
G
K
T
D
----------------------
R
---------------------
S
-
V
L
L
W
M
-
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
-
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
----
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
REGA
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
---
Q
E
K
D
E
G
K
---
R
V
I
D
R
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
--
P
-
G
--
R
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
R
T
E
-
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
Y
A
Q
L
H
K
M
Q
F
-----------
28
PsiBlast_CBE
86.91
33%
-
- C1 -
3B5Z
2
MSBA_SALTY
B:
[32-580]
-----------------------------
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
----
D
G
-
F
-
G
K
T
D
----------------------
R
---------------------
S
-
V
L
L
W
M
-
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
-
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
----
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
REGA
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
---
Q
E
K
D
E
G
K
---
R
V
I
D
R
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
--
P
-
G
--
R
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
R
T
E
-
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
Y
A
Q
L
H
K
M
Q
F
-----------
30
PsiBlast_CBE
86.86
33%
-
- C1 -
3B5Y
2
MSBA_SALTY
C:
[32-580]
-----------------------------
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
----
D
G
-
F
-
G
K
T
D
----------------------
R
---------------------
S
-
V
L
L
W
M
-
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
-
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
----
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
REGA
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
---
Q
E
K
D
E
G
K
---
R
V
I
D
R
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
--
P
-
G
--
R
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
R
T
E
-
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
Y
A
Q
L
H
K
M
Q
F
-----------
29
PsiBlast_CBE
86.86
33%
-
- C1 -
3B5Y
2
MSBA_SALTY
D:
[32-580]
-----------------------------
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
----
D
G
-
F
-
G
K
T
D
----------------------
R
---------------------
S
-
V
L
L
W
M
-
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
-
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
----
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
REGA
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
---
Q
E
K
D
E
G
K
---
R
V
I
D
R
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
--
P
-
G
--
R
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
R
T
E
-
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
Y
A
Q
L
H
K
M
Q
F
-----------
8
PsiBlast_PDB
86.86
33%
-
- C1 -
3B5Y
2
MSBA_SALTY
A:
[32-580]
-----------------------------
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
----
D
G
-
F
-
G
K
T
D
----------------------
R
---------------------
S
-
V
L
L
W
M
-
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
-
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
----
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
---
Q
E
K
D
E
G
K
---
R
V
I
D
R
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
--
P
-
G
--
R
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
R
T
E
-
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
Y
A
Q
L
H
K
M
Q
F
-----------
31
PsiBlast_CBE
86.85
33%
-
- C1 -
3B5Y
2
MSBA_SALTY
B:
[32-580]
-----------------------------
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
----
D
G
-
F
-
G
K
T
D
----------------------
R
---------------------
S
-
V
L
L
W
M
-
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
-
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
----
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
REGA
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
---
Q
E
K
D
E
G
K
---
R
V
I
D
R
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
--
P
-
G
--
R
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
R
T
E
-
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
H
G
V
Y
A
Q
L
H
K
M
Q
F
-----------
11
PsiBlast_PDB
84.16
34%
-
- C1 -
3B5X
-
MSBA_VIBCH
A:
[32-572]
-----------------------------
I
A
L
V
I
N
A
A
A
D
T
Y
M
I
S
L
L
K
P
L
L
D
E
G
F
--
G
-
N
-
A
E
S
N
----------------------
F
---------------------
L
-
R
I
-
L
P
-
F
M
I
L
G
L
M
F
V
R
-
G
L
S
G
F
-
A
S
S
Y
C
L
S
W
V
S
G
N
V
V
M
Q
M
R
R
R
L
F
N
H
F
M
H
M
P
V
R
F
F
D
Q
E
S
T
G
G
L
L
S
R
I
T
Y
D
S
E
Q
V
A
G
A
T
S
R
A
L
V
S
I
V
R
E
G
A
----
S
I
I
G
L
L
T
L
M
F
W
N
S
W
Q
L
S
L
V
L
I
V
V
A
P
V
V
A
F
A
I
S
F
V
S
K
R
F
R
K
I
S
R
N
M
Q
T
A
M
G
H
V
T
S
S
A
E
Q
M
L
K
G
H
K
V
V
L
S
Y
G
G
Q
E
V
E
R
K
R
F
D
K
V
S
N
S
M
R
Q
Q
T
M
K
L
V
S
A
Q
S
I
A
D
P
V
I
Q
M
I
A
S
L
A
L
F
A
V
L
F
L
A
S
V
D
S
I
R
A
E
L
T
P
G
T
F
T
V
V
F
S
A
M
F
G
L
M
R
P
L
K
A
L
T
S
V
T
S
E
F
Q
R
G
M
A
A
C
Q
T
L
F
G
L
M
D
L
E
---
T
E
R
D
N
G
K
---
Y
E
A
E
R
V
N
G
E
V
D
V
K
D
V
T
F
T
Y
--
Q
G
K
--
E
K
P
-
A
L
S
H
V
S
F
S
I
P
Q
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
N
L
F
T
R
F
Y
D
V
D
S
G
S
I
C
L
D
G
H
D
V
R
D
Y
K
L
T
N
L
R
R
H
F
A
L
V
S
Q
N
V
H
L
F
N
D
T
I
A
N
N
I
A
Y
A
A
E
G
-
E
Y
T
R
E
Q
I
E
Q
A
A
R
Q
A
H
A
M
E
F
I
E
N
M
P
Q
G
L
D
T
V
I
G
E
N
G
T
S
L
S
G
G
Q
R
Q
R
V
A
I
A
R
A
L
L
R
D
A
P
V
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
K
T
V
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
L
V
V
D
E
G
E
I
I
E
R
G
R
H
A
D
L
L
A
Q
D
G
A
Y
-------------------
115
HHSearch
83.80
32%
-
- C1 -
3B5X
-
MSBA_VIBCH
A:
[10-580]
-----------
W
Q
T
F
K
R
L
W
T
Y
I
R
L
Y
K
A
G
-
L
V
V
S
T
I
A
L
V
I
N
A
A
A
D
T
Y
M
I
S
L
L
K
P
L
L
D
E
G
F
-
G
N
A
E
----------------------
S
---------------------
N
F
L
R
-
I
L
P
F
M
I
L
G
L
M
F
V
R
G
L
S
G
F
A
-
S
S
-
Y
C
L
S
W
V
S
G
N
V
V
M
Q
M
R
R
R
L
F
N
H
F
M
H
M
P
V
R
F
F
D
Q
E
S
T
G
G
L
L
S
R
I
T
Y
D
S
E
Q
V
A
G
A
T
S
R
A
L
V
S
I
V
R
E
G
A
----
S
I
I
G
L
L
T
L
M
F
W
N
S
W
Q
L
S
L
V
L
I
V
V
A
P
V
V
A
F
A
I
S
F
V
S
K
R
F
R
K
I
S
R
N
M
Q
T
A
M
G
H
V
T
S
S
A
E
Q
M
L
K
G
H
K
V
V
L
S
Y
G
G
Q
E
V
E
R
K
R
F
D
K
V
S
N
S
M
R
Q
Q
T
M
K
L
V
S
A
Q
S
I
A
D
P
V
I
Q
M
I
A
S
L
A
L
F
A
V
L
F
L
A
S
V
D
S
I
R
A
E
L
T
P
G
T
F
T
V
V
F
S
A
M
F
G
L
M
R
P
L
K
A
L
T
S
V
T
S
E
F
Q
R
G
M
A
A
C
Q
T
L
F
G
L
M
D
L
E
---
T
E
R
D
N
G
K
---
Y
E
A
E
R
V
N
G
E
V
D
V
K
D
V
T
F
T
Y
--
Q
-
G
K-
E
K
P
-
A
L
S
H
V
S
F
S
I
P
Q
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
N
L
F
T
R
F
Y
D
V
D
S
G
S
I
C
L
D
G
H
D
V
R
D
Y
K
L
T
N
L
R
R
H
F
A
L
V
S
Q
N
V
H
L
F
N
D
T
I
A
N
N
I
A
Y
A
A
E
G
E
Y
T
-
R
E
Q
I
E
Q
A
A
R
Q
A
H
A
M
E
F
I
E
N
M
P
Q
G
L
D
T
V
I
G
E
N
G
T
S
L
S
G
G
Q
R
Q
R
V
A
I
A
R
A
L
L
R
D
A
P
V
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
K
T
V
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
L
V
V
D
E
G
E
I
I
E
R
G
R
H
A
D
L
L
A
Q
D
G
A
Y
A
Q
L
H
R
I
Q
F
-----------
48
PsiBlast_CBE
81.44
35%
0
- C- -
4M2S
1
MDR1A_MOUSE
A:
[140-672]
--------------------------------------------------------------------------------------------------------------------------------------------------
I
H
K
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
F
D
V
H
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
I
G
M
F
F
Q
A
M
A
----
T
F
F
G
G
F
I
I
G
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
L
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
K
E
L
E
R
Y
N
N
N
L
E
E
A
K
R
L
G
I
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
L
I
Y
A
S
Y
A
L
A
F
W
Y
G
T
S
L
V
I
S
K
E
Y
S
I
G
Q
V
L
T
V
F
F
S
V
L
I
G
A
F
S
V
G
Q
A
S
P
N
I
E
A
F
A
N
A
R
G
A
A
Y
E
V
F
K
I
I
D
N
K
PSI
D
S
F
S
K
S
G
---
H
K
P
D
N
I
Q
G
N
L
E
F
K
N
I
H
F
S
Y
PS
R
-
K
--
E
V
Q
-
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
R
E
--
D
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
P
H
Q
F
D
T
L
V
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
E
G
R
T
T
I
V
I
A
H
R
L
S
T
V
R
N
A
D
V
I
A
G
F
D
G
G
V
I
V
E
Q
G
N
H
D
E
L
M
R
E
K
G
I
Y
-------------------
47
PsiBlast_CBE
81.44
35%
0
- C- -
4M2S
1
MDR1A_MOUSE
B:
[140-679]
--------------------------------------------------------------------------------------------------------------------------------------------------
I
H
K
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
F
D
V
H
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
I
G
M
F
F
Q
A
M
A
----
T
F
F
G
G
F
I
I
G
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
L
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
K
E
L
E
R
Y
N
N
N
L
E
E
A
K
R
L
G
I
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
L
I
Y
A
S
Y
A
L
A
F
W
Y
G
T
S
L
V
I
S
K
E
Y
S
I
G
Q
V
L
T
V
F
F
S
V
L
I
G
A
F
S
V
G
Q
A
S
P
N
I
E
A
F
A
N
A
R
G
A
A
Y
E
V
F
K
I
I
D
N
K
PSI
D
S
F
S
K
S
G
---
H
K
P
D
N
I
Q
G
N
L
E
F
K
N
I
H
F
S
Y
PS
R
-
K
--
E
V
Q
-
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
R
E
--
D
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
P
H
Q
F
D
T
L
V
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
E
G
R
T
T
I
V
I
A
H
R
L
S
T
V
R
N
A
D
V
I
A
G
F
D
G
G
V
I
V
E
Q
G
N
H
D
E
L
M
R
E
K
G
I
Y
-------------------
46
PsiBlast_CBE
81.44
35%
0
- C- -
4M2T
2
MDR1A_MOUSE
A:
[140-672]
--------------------------------------------------------------------------------------------------------------------------------------------------
I
H
K
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
F
D
V
H
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
I
G
M
F
F
Q
A
M
A
----
T
F
F
G
G
F
I
I
G
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
L
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
K
E
L
E
R
Y
N
N
N
L
E
E
A
K
R
L
G
I
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
L
I
Y
A
S
Y
A
L
A
F
W
Y
G
T
S
L
V
I
S
K
E
Y
S
I
G
Q
V
L
T
V
F
F
S
V
L
I
G
A
F
S
V
G
Q
A
S
P
N
I
E
A
F
A
N
A
R
G
A
A
Y
E
V
F
K
I
I
D
N
K
PSI
D
S
F
S
K
S
G
---
H
K
P
D
N
I
Q
G
N
L
E
F
K
N
I
H
F
S
Y
PS
R
-
K
--
E
V
Q
-
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
R
E
--
D
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
P
H
Q
F
D
T
L
V
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
E
G
R
T
T
I
V
I
A
H
R
L
S
T
V
R
N
A
D
V
I
A
G
F
D
G
G
V
I
V
E
Q
G
N
H
D
E
L
M
R
E
K
G
I
Y
-------------------
45
PsiBlast_CBE
81.44
35%
0
- C- -
4M2T
2
MDR1A_MOUSE
B:
[140-679]
--------------------------------------------------------------------------------------------------------------------------------------------------
I
H
K
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
F
D
V
H
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
I
G
M
F
F
Q
A
M
A
----
T
F
F
G
G
F
I
I
G
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
L
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
K
E
L
E
R
Y
N
N
N
L
E
E
A
K
R
L
G
I
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
L
I
Y
A
S
Y
A
L
A
F
W
Y
G
T
S
L
V
I
S
K
E
Y
S
I
G
Q
V
L
T
V
F
F
S
V
L
I
G
A
F
S
V
G
Q
A
S
P
N
I
E
A
F
A
N
A
R
G
A
A
Y
E
V
F
K
I
I
D
N
K
PSI
D
S
F
S
K
S
G
---
H
K
P
D
N
I
Q
G
N
L
E
F
K
N
I
H
F
S
Y
PS
R
-
K
--
E
V
Q
-
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
R
E
--
D
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
P
H
Q
F
D
T
L
V
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
E
G
R
T
T
I
V
I
A
H
R
L
S
T
V
R
N
A
D
V
I
A
G
F
D
G
G
V
I
V
E
Q
G
N
H
D
E
L
M
R
E
K
G
I
Y
-------------------
44
PsiBlast_CBE
81.44
35%
0
- C- -
4M1M
3
MDR1A_MOUSE
A:
[140-672]
--------------------------------------------------------------------------------------------------------------------------------------------------
I
H
K
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
F
D
V
H
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
I
G
M
F
F
Q
A
M
A
----
T
F
F
G
G
F
I
I
G
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
L
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
K
E
L
E
R
Y
N
N
N
L
E
E
A
K
R
L
G
I
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
L
I
Y
A
S
Y
A
L
A
F
W
Y
G
T
S
L
V
I
S
K
E
Y
S
I
G
Q
V
L
T
V
F
F
S
V
L
I
G
A
F
S
V
G
Q
A
S
P
N
I
E
A
F
A
N
A
R
G
A
A
Y
E
V
F
K
I
I
D
N
K
PSI
D
S
F
S
K
S
G
---
H
K
P
D
N
I
Q
G
N
L
E
F
K
N
I
H
F
S
Y
PS
R
-
K
--
E
V
Q
-
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
R
E
--
D
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
P
H
Q
F
D
T
L
V
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
E
G
R
T
T
I
V
I
A
H
R
L
S
T
V
R
N
A
D
V
I
A
G
F
D
G
G
V
I
V
E
Q
G
N
H
D
E
L
M
R
E
K
G
I
Y
-------------------
43
PsiBlast_CBE
81.44
35%
0
- C- -
4M1M
3
MDR1A_MOUSE
B:
[140-679]
--------------------------------------------------------------------------------------------------------------------------------------------------
I
H
K
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
F
D
V
H
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
I
G
M
F
F
Q
A
M
A
----
T
F
F
G
G
F
I
I
G
F
T
R
G
W
K
L
T
L
V
I
L
A
I
S
P
V
L
G
L
S
A
G
I
W
A
K
I
L
S
S
F
T
D
K
E
L
H
A
Y
A
K
A
G
A
V
A
E
E
V
L
A
A
I
R
T
V
I
A
F
G
G
Q
K
K
E
L
E
R
Y
N
N
N
L
E
E
A
K
R
L
G
I
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
L
I
Y
A
S
Y
A
L
A
F
W
Y
G
T
S
L
V
I
S
K
E
Y
S
I
G
Q
V
L
T
V
F
F
S
V
L
I
G
A
F
S
V
G
Q
A
S
P
N
I
E
A
F
A
N
A
R
G
A
A
Y
E
V
F
K
I
I
D
N
K
PSI
D
S
F
S
K
S
G
---
H
K
P
D
N
I
Q
G
N
L
E
F
K
N
I
H
F
S
Y
PS
R
-
K
--
E
V
Q
-
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
V
Q
L
M
Q
R
L
Y
D
P
L
D
G
M
V
S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
E
P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
R
E
--
D
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
P
H
Q
F
D
T
L
V
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
E
G
R
T
T
I
V
I
A
H
R
L
S
T
V
R
N
A
D
V
I
A
G
F
D
G
G
V
I
V
E
Q
G
N
H
D
E
L
M
R
E
K
G
I
Y
-------------------
42
PsiBlast_CBE
81.44
35%
0
- C- -
3G5U
1
MDR1A_MOUSE
A:
[140-675]
--------------------------------------------------------------------------------------------------------------------------------------------------
I
H
K
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
F
D
V
H
D
V
G
E
L
N
T
R
L
T
D
D
V
S
K
I
N
E
G
I
G
D
K
I
G
M
F
F
Q
A
M
A
----
T
F
F
G
G
F
I
I
G
F
T
R
G
W
K
L
T
L
V
I
L
A
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L
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L
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I
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S
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L
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T
V
I
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G
Q
K
K
E
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Y
N
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L
E
E
A
K
R
L
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I
K
K
A
I
T
A
N
I
S
M
G
A
A
F
L
L
I
Y
A
S
Y
A
L
A
F
W
Y
G
T
S
L
V
I
S
K
E
Y
S
I
G
Q
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L
T
V
F
F
S
V
L
I
G
A
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A
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P
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I
E
A
F
A
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G
A
A
Y
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V
F
K
I
I
D
N
K
PSI
D
S
F
S
K
S
G
---
H
K
P
D
N
I
Q
G
N
L
E
F
K
N
I
H
F
S
Y
PS
R
-
K
--
E
V
Q
-
I
L
K
G
L
N
L
K
V
K
S
G
Q
T
V
A
L
V
G
N
S
G
C
G
K
S
T
T
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Q
L
M
Q
R
L
Y
D
P
L
D
G
M
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S
I
D
G
Q
D
I
R
T
I
N
V
R
Y
L
R
E
I
I
G
V
V
S
Q
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P
V
L
F
A
T
T
I
A
E
N
I
R
Y
G
R
E
--
D
V
T
M
D
E
I
E
K
A
V
K
E
A
N
A
Y
D
F
I
M
K
L
P
H
Q
F
D
T
L
V
G
E
R
G
A
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
T
E
S
E
A
V
V
Q
A
A
L
D
K
A
R
E
G
R
T
T
I
V
I
A
H
R
L
S
T
V
R
N
A
D
V
I
A
G
F
D
G
G
V
I
V
E
Q
G
N
H
D
E
L
M
R
E
K
G
I
Y
-------------------
41
PsiBlast_CBE
81.44
35%
0
- C- -
3G5U
1
MDR1A_MOUSE
B:
[140-675]
--------------------------------------------------------------------------------------------------------------------------------------------------
I
H
K
I
R
Q
K
F
F
H
A
I
M
N
Q
E
I
G
W
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R
L
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D
V
S
K
I
N
E
G
I
G
D
K
I
G
M
F
F
Q
A
M
A
----
T
F
F
G
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F
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I
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G
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T
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L
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PSI
D
S
F
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K
S
G
---
H
K
P
D
N
I
Q
G
N
L
E
F
K
N
I
H
F
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Y
PS
R
-
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--
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V
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-
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L
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M
R
E
K
G
I
Y
-------------------