@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu35010: (2016-07-29 )
MAESLLIKDIAIVTENEVIKNGYVGINDGKISTVSTERPKEPYSKEIQAPADSVLLPGMIDIHIHGGYGADTMDASFSTLDIMSSRLPEEGTTSFLATTITQEHGNISQALVNAREWKAAEESSLLGAELLGIHLEGPFVSPKRAGAQPKEWIRPSDVELFKKWQQEAGGLIKIVTLAPEEDQHFELIRHLKDESIIASMGHTDADSALLSDAAKAGASHMTHLYNAMSPFHHREPGVIGTALAHDGFVTELIADGIHSHPLAAKLAFLAKGSSKLILITDSMRAKGLKDGVYEFGGQSVTVRGRTALLSDGTLAGSILKMNEGARHMREFTNCSWTDIANITSENAAKQLGIFDRKGSVTVGKDADLVIVSSDCEVILTICRGNIAFISKEADQI
Atome Classification :
(20 SA)
.........10....-....20........30....--....40.........50-.........60........70--....-.-.----...80........90........100.......110.......120.......130.......140.......150...-....160.......170.......180.-......190.......200.......210.......220.......230.......240.......250.......260.......270..--......280....-...290.......300....-----.----..-310...---....320.......330.......340.......350.......360.......370.......380.......390....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAES
L
L
I
K
D
I
A
I
V
TE-N
E
V
IKN
G
Y
V
GINDG
K
I
S
TVS--TERPK-EP
Y
S
K
EIQAP--ADSVLLP
G
M
I
D
I
H
I
HGGYGA---DTMD-A-S----
F
S
T
L
D
I
M
S
S
RLPEEGT
T
S
F
L
A
T
T
I
T
Q
EHG
N
I
S
Q
A
L
V
N
A
R
E
WKAA
E
E
SSLLG
A
E
L
L
G
I
H
LEGPFVSPKRAGAQ
P
K
EWIRP-
S
D
V
E
L
F
K
K
W
Q
Q
EAG
G
L
I
K
I
V
T
LAPEE
D
Q
-
H
F
E
L
I
R
H
LKD
E
S
I
I
A
SMGHTD
A
D
S
A
L
L
S
D
A
A
K
A
G
A
S
H
M
T
H
L
Y
N
AMSPFHHREPG
V
I
G
T
ALAHD
G
F
V
T
E
L
I
ADGIHSH
P
L
A
A
K
L
A
F
L
A-KGS--
S
K
L
I
L
I
TD
S
M
RAK-GLKD
G
V
Y
E
FGG
Q
S
V
T
V
RG
R
T
-----
A
----LL-SDGTLA---G
S
I
LKM
N
E
G
A
R
H
M
R
E
F
TNCSW
T
D
I
A
N
IT
S
E
N
A
A
K
QLGIFDRKG
S
V
T
VGKDA
D
L
V
I
VSSD
C
E
V
I
L
T
I
CRG
N
I
A
F
ISKEADQI
21
PsiBlast_CBE
94.68
100%
-76
- C1 -
2VHL
4
NAGA_BACSU
B:
[2-394]
-
A
E
S
L
L
I
K
D
I
A
I
V
T
E
-
N
E
V
I
K
N
G
Y
V
G
I
N
D
G
K
I
S
T
V
S
--
T
E
R
P
K
-
E
P
Y
S
K
E
I
Q
A
P
--
A
D
S
V
L
L
P
G
M
I
D
I
H
I
H
G
G
Y
G
A
---
D
T
M
D
-
A
-
S
----
F
S
T
L
D
I
M
S
S
R
L
P
E
E
G
T
T
S
F
L
A
T
T
I
T
Q
E
H
G
N
I
S
Q
A
L
V
N
A
R
E
W
K
A
A
E
E
S
S
L
L
G
A
E
L
L
G
I
H
L
E
G
P
F
V
S
P
K
R
A
G
A
Q
P
K
E
W
I
R
P
-
S
D
V
E
L
F
K
K
W
Q
Q
E
A
G
G
L
I
K
I
V
T
L
A
P
E
E
D
Q
-
H
F
E
L
I
R
H
L
K
D
E
S
I
I
A
S
M
G
H
T
D
A
D
S
A
L
L
S
D
A
A
K
A
G
A
S
H
M
T
H
L
Y
N
A
M
S
P
F
H
H
R
E
P
G
V
I
G
T
A
L
A
H
D
G
F
V
T
E
L
I
A
D
G
I
H
S
H
P
L
A
A
K
L
A
F
L
A
-
K
G
S
--
S
K
L
I
L
I
T
D
S
M
R
A
K
-
G
L
K
D
G
V
Y
E
F
G
G
Q
S
V
T
V
R
G
R
T
-----
A
----
L
L
-
S
D
G
T
L
A
---
G
S
I
L
K
M
N
E
G
A
R
H
M
R
E
F
T
N
C
S
W
T
D
I
A
N
I
T
S
E
N
A
A
K
Q
L
G
I
F
D
R
K
G
S
V
T
V
G
K
D
A
D
L
V
I
V
S
S
D
C
E
V
I
L
T
I
C
R
G
N
I
A
F
I
S
K
E
A
D
--
1
PsiBlast_PDB
93.99
100%
-75
* C1 *
2VHL
4
NAGA_BACSU
A:
[3-394]
--
E
S
L
L
I
K
D
I
A
I
V
T
E
-
N
E
V
I
K
N
G
Y
V
G
I
N
D
G
K
I
S
T
V
S
--
T
E
R
P
K
-
E
P
Y
S
K
E
I
Q
A
P
--
A
D
S
V
L
L
P
G
M
I
D
I
H
I
H
G
G
Y
G
A
---
D
T
M
D
-
A
-
S
----
F
S
T
L
D
I
M
S
S
R
L
P
E
E
G
T
T
S
F
L
A
T
T
I
T
Q
E
H
G
N
I
S
Q
A
L
V
N
A
R
E
W
K
A
A
E
E
S
S
L
L
G
A
E
L
L
G
I
H
L
E
G
P
F
V
S
P
K
R
A
G
A
Q
P
K
E
W
I
R
P
-
S
D
V
E
L
F
K
K
W
Q
Q
E
A
G
G
L
I
K
I
V
T
L
A
P
E
E
D
Q
-
H
F
E
L
I
R
H
L
K
D
E
S
I
I
A
S
M
G
H
T
D
A
D
S
A
L
L
S
D
A
A
K
A
G
A
S
H
M
T
H
L
Y
N
A
M
S
P
F
H
H
R
E
P
G
V
I
G
T
A
L
A
H
D
G
F
V
T
E
L
I
A
D
G
I
H
S
H
P
L
A
A
K
L
A
F
L
A
-
K
G
S
--
S
K
L
I
L
I
T
D
S
M
R
A
K
-
G
L
K
D
G
V
Y
E
F
G
G
Q
S
V
T
V
R
G
R
T
-----
A
----
L
L
-
S
D
G
T
L
A
---
G
S
I
L
K
M
N
E
G
A
R
H
M
R
E
F
T
N
C
S
W
T
D
I
A
N
I
T
S
E
N
A
A
K
Q
L
G
I
F
D
R
K
G
S
V
T
V
G
K
D
A
D
L
V
I
V
S
S
D
C
E
V
I
L
T
I
C
R
G
N
I
A
F
I
S
K
E
A
D
--
82
HHSearch
80.92
89%
-1
- C1 -
2VHL
4
NAGA_BACSU
A:
[3-394]
--
E
S
L
L
I
K
D
I
A
I
V
T
E
-
N
E
V
I
K
N
G
Y
V
G
I
N
D
G
K
I
S
T
V
S
--
T
E
R
P
K
E
P
Y
S
K
E
I
Q
A
P
A
--
D
S
-
V
L
L
P
G
M
I
D
I
H
I
H
G
G
Y
G
A
---
D
T
M
D
-
A
-
S
----
F
S
T
L
D
I
M
S
S
R
L
P
E
E
G
T
T
S
F
L
A
T
T
I
T
Q
E
H
G
N
I
S
Q
A
L
V
N
A
R
E
W
K
A
A
E
E
S
S
L
L
G
A
E
L
L
G
I
H
L
E
G
P
F
V
S
P
K
R
A
G
A
Q
P
K
E
W
I
R
P
-
S
D
V
E
L
F
K
K
W
Q
Q
E
A
G
G
L
I
K
I
V
T
L
A
P
E
E
D
Q
H
F
E
L
I
R
H
L
K
D
E
S
I
I
A
S
M
-
G
H
T
D
A
D
S
A
L
L
S
D
A
A
K
A
G
A
S
H
M
T
H
L
Y
N
A
M
S
P
F
H
H
R
E
P
G
V
I
G
T
A
L
A
H
D
G
F
V
T
E
L
I
A
D
G
I
H
S
H
P
L
A
A
K
L
A
F
L
A
K
G
S
---
S
K
L
I
L
I
T
-
D
S
M
R
A
K
G
L
K
D
G
V
Y
E
F
------
G
G
Q
S
V
T
V
R
GR
T
----
A
L
L
S
D
G
T
L
A
---
G
S
I
L
K
M
N
E
G
A
R
H
M
R
E
F
T
N
C
S
W
T
D
I
A
N
I
T
S
E
N
A
A
K
Q
L
G
I
F
D
R
K
G
S
V
T
V
G
K
D
A
D
L
V
I
V
S
S
D
C
E
V
I
L
T
I
C
R
G
N
I
A
F
I
S
K
E
A
D
--
2
PsiBlast_PDB
67.50
36%
-19
- C1 -
1O12
1
?
A:
[29-376]
---------------------
T
G
D
V
E
I
E
E
G
K
I
V
K
V
E
--
K
R
-----------
E
C
I
--
P
R
G
V
L
M
P
G
F
V
D
P
H
I
H
G
V
V
G
A
---
D
T
M
N
-
C
-
D
----
F
S
E
M
E
E
F
---
L
Y
S
Q
G
V
T
T
F
L
A
T
T
V
S
T
S
L
E
K
M
K
E
I
L
R
K
A
R
D
Y
I
L
E
N
P
S
T
----
S
L
L
G
V
H
L
E
G
P
Y
I
S
K
E
K
K
G
A
H
S
E
K
H
I
R
P
P
S
E
R
E
L
-----
S
E
I
D
S
P
A
K
M
L
T
F
A
P
E
I
E
S
-
S
-
E
L
L
L
R
L
V
K
R
D
I
V
L
S
A
G
H
S
I
A
T
F
E
E
F
M
K
F
Y
K
E
G
V
K
R
I
T
H
F
P
N
G
L
K
P
L
H
H
R
E
I
G
I
T
G
A
G
L
L
L
D
D
V
K
L
E
L
I
C
D
G
V
H
L
S
R
E
M
V
K
L
V
Y
K
V
-
K
K
A
--
N
G
I
V
L
V
T
D
S
I
S
A
A
-
G
L
K
D
G
T
T
T
L
G
D
L
V
V
K
V
K
D
G
V
-----
P
----
R
L
-
E
D
G
T
L
A
---
G
S
T
L
F
F
S
Q
A
V
K
N
F
R
K
F
T
G
C
S
I
T
E
L
A
K
V
S
S
Y
N
S
C
V
E
L
G
L
D
D
R
-
G
R
I
A
E
G
T
R
A
D
L
V
L
L
D
E
D
L
N
V
V
M
T
I
K
E
G
E
V
V
F
R
S
R
-----
84
HHSearch
67.40
31%
-28
- C1 -
3IV8
3
NAGA_VIBCH
A:
[3-381]
--
A
M
Y
A
L
T
N
C
K
I
Y
T
G
-
N
D
V
L
V
K
H
A
V
I
I
N
G
D
K
I
E
A
V
C
--
P
I
E
S
L
-
P
S
E
M
N
V
V
D
L
N
--
G
A
-
N
L
S
P
G
F
I
D
L
Q
L
N
G
C
G
G
V
---
M
F
N
D
E
I
-
T
----
A
E
T
I
D
T
M
H
K
A
N
L
K
S
G
C
T
S
F
L
P
T
L
I
T
S
S
D
E
N
M
R
Q
A
I
A
A
A
R
E
Y
Q
A
K
-----
Y
P
N
Q
S
L
G
L
H
L
E
G
P
Y
L
N
V
M
K
K
G
I
H
S
V
D
F
I
R
P
-
S
-
D
D
T
M
I
D
T
I
C
A
N
S
D
V
I
A
K
V
T
L
A
P
E
N
N
K
--
P
E
H
I
E
K
L
V
K
A
G
I
V
V
S
I
G
H
T
N
A
T
Y
S
E
A
R
K
S
F
E
S
G
I
T
F
A
T
H
L
F
N
A
M
T
P
M
V
G
R
E
P
G
V
V
G
A
I
Y
D
T
P
E
V
Y
A
G
I
I
A
D
G
F
H
V
D
Y
A
N
I
R
I
A
H
K
I
-
K
G
---
E
K
L
V
L
V
T
D
A
T
A
P
A
-
G
A
E
M
D
Y
F
I
F
V
G
K
K
V
Y
Y
R
D
G
K
-----
C
----
V
D
-
E
N
G
T
L
G
---
G
S
A
L
T
M
I
E
A
V
Q
N
T
V
E
H
V
G
I
A
L
D
E
A
L
R
M
A
T
L
Y
P
A
K
A
I
G
V
D
E
K
L
G
R
I
K
K
G
M
I
A
N
L
T
V
F
D
R
D
F
N
V
K
A
T
V
V
N
G
Q
Y
E
Q
N
-------
3
PsiBlast_PDB
66.64
31%
6
- C1 -
3EGJ
2
NAGA_VIBCH
A:
[7-376]
------
L
T
N
C
K
I
Y
T
G
-
N
D
V
L
V
K
H
A
V
I
I
N
G
D
K
I
E
A
V
C
-----
P
I
-
E
S
L
P
S
E
M
N
V
V
D
L
N
G
A
N
L
S
P
G
F
I
D
L
Q
L
N
G
C
G
G
V
---
M
F
N
D
-
E
I
T
----
A
E
T
I
D
T
M
H
K
A
N
L
K
S
G
C
T
S
F
L
P
T
L
I
T
S
S
D
E
N
M
R
Q
A
I
A
A
A
R
E
Y
Q
A
K
Y
P
N
-----
Q
S
L
G
L
H
L
E
G
P
Y
L
N
V
M
K
K
G
I
H
S
V
D
F
I
R
P
-
S
D
D
T
M
I
D
T
I
C
A
N
S
D
V
I
A
K
-
V
T
L
A
P
E
N
N
K
-
P
-
E
H
I
E
K
L
V
K
A
G
I
V
V
S
I
G
H
T
N
A
T
Y
S
E
A
R
K
S
F
E
S
G
I
T
F
A
T
H
L
F
N
A
M
T
P
M
V
G
R
E
P
G
V
V
G
A
I
Y
D
T
P
E
V
Y
A
G
I
I
A
D
G
F
H
V
D
Y
A
N
I
R
I
A
H
K
I
-
K
G
---
E
K
L
V
L
V
T
D
A
T
A
P
A
-
G
A
E
M
D
Y
F
I
F
V
G
K
K
V
Y
Y
R
D
G
K
-----
C
----
V
D
-
E
N
G
T
L
G
---
G
S
A
L
T
M
I
E
A
V
Q
N
T
V
E
H
V
G
I
A
L
D
E
A
L
R
M
A
T
L
Y
P
A
K
A
I
G
V
D
E
K
L
G
R
I
K
K
G
M
I
A
N
L
T
V
F
D
R
D
F
N
V
K
A
T
V
V
N
G
------------
83
HHSearch
66.35
30%
-25
- C1 -
1YRR
4
NAGA_ECOLI
A:
[1-381]
---
M
Y
A
L
T
Q
G
R
I
F
T
G
-
H
E
F
L
D
D
H
A
V
V
I
A
D
G
L
I
K
S
V
C
--
P
V
A
E
L
-
P
P
E
I
E
Q
R
S
L
N
--
G
A
-
I
L
S
P
G
F
I
D
V
Q
L
N
G
C
G
G
V
---
Q
F
N
D
-
T
-
A
EAVS
V
E
T
L
E
I
M
Q
K
A
N
E
K
S
G
C
T
N
Y
L
P
T
L
I
T
T
S
D
E
L
M
K
Q
G
V
R
V
M
R
E
Y
L
A
K
-----
H
P
N
Q
A
L
G
L
H
L
E
G
P
W
L
N
L
V
K
K
-
T
H
N
P
N
F
V
R
K
-
P
D
A
A
L
V
D
F
L
-
C
E
N
A
D
V
I
T
K
V
T
L
A
P
E
M
V
--
P
A
E
V
I
S
K
L
A
N
A
G
I
V
V
S
A
G
H
S
N
A
T
L
K
E
A
K
A
G
F
R
A
G
I
T
F
A
T
H
L
Y
N
A
M
P
Y
I
T
G
R
E
P
G
L
A
G
A
I
L
D
E
A
D
I
Y
C
G
I
I
A
D
G
L
H
V
D
Y
A
N
I
R
N
A
K
R
L
-
K
G
---
D
K
L
C
L
V
T
D
A
T
A
P
A
-
G
-----
A
N
I
---
E
Q
F
I
F
A
G
K
T
----
I
Y
YRN
G
L
-
C
V
D
E
N
G
TLS
G
S
S
L
T
M
I
E
G
V
R
N
L
V
E
H
C
G
I
A
L
D
E
V
L
R
M
A
T
L
Y
P
A
R
A
I
G
V
E
K
R
L
G
T
L
A
A
G
K
V
A
N
L
T
A
F
T
P
D
F
K
I
T
K
T
I
V
N
G
N
E
V
V
T
-------
24
PsiBlast_CBE
65.74
31%
7
- C1 -
3IV8
3
NAGA_VIBCH
B:
[7-376]
------
L
T
N
C
K
I
Y
T
G
-
N
D
V
L
V
K
H
A
V
I
I
N
G
D
K
I
E
A
V
C
-----
P
I
-
E
S
L
P
S
E
M
N
V
V
D
L
N
G
A
N
L
S
P
G
F
I
D
L
Q
L
N
G
C
G
G
V
---
M
F
N
D
-
E
I
T
----
A
E
T
I
D
T
M
H
K
A
N
L
K
S
G
C
T
S
F
L
P
T
L
I
T
S
S
D
E
N
M
R
Q
A
I
A
A
A
R
E
Y
Q
A
K
Y
P
N
-----
Q
S
L
G
L
H
L
E
G
P
Y
L
N
V
M
K
K
G
I
H
S
V
D
F
I
R
P
-
S
D
D
T
M
I
D
T
I
C
A
N
S
D
V
I
A
K
-
V
T
L
A
P
E
N
N
K
-
P
-
E
H
I
E
K
L
V
K
A
G
I
V
V
S
I
G
H
T
N
A
T
Y
S
E
A
R
K
S
F
E
S
G
I
T
F
A
T
H
L
F
N
A
M
T
P
M
V
G
R
E
P
G
V
V
G
A
I
Y
D
T
P
E
V
Y
A
G
I
I
A
D
G
F
H
V
D
Y
A
N
I
R
I
A
H
K
I
-
K
G
---
E
K
L
V
L
V
T
D
A
T
A
P
A
-
G
A
E
M
D
Y
F
I
F
V
G
K
K
V
Y
Y
R
D
G
K
-----
C
----
V
D
-
E
N
G
T
L
G
---
G
S
A
L
T
M
I
E
A
V
Q
N
T
V
E
H
V
G
I
A
L
D
E
A
L
R
M
A
T
L
Y
P
A
K
A
I
G
V
D
E
K
L
G
R
I
K
K
G
M
I
A
N
L
T
V
F
D
R
D
F
N
V
K
A
T
V
V
N
G
------------
23
PsiBlast_CBE
65.65
31%
6
- C1 -
3IV8
3
NAGA_VIBCH
C:
[7-376]
------
L
T
N
C
K
I
Y
T
G
-
N
D
V
L
V
K
H
A
V
I
I
N
G
D
K
I
E
A
V
C
-----
P
I
-
E
S
L
P
S
E
M
N
V
V
DL
N
G
A
N
L
S
P
G
F
I
D
L
Q
L
N
G
C
G
G
V
---
M
F
N
D
-
E
I
T
----
A
E
T
I
D
T
M
H
K
A
N
L
K
S
G
C
T
S
F
L
P
T
L
I
T
S
S
D
E
N
M
R
Q
A
I
A
A
A
R
E
Y
Q
A
K
Y
P
N
-----
Q
S
L
G
L
H
L
E
G
P
Y
L
N
V
M
K
K
G
I
H
S
V
D
F
I
R
P
-
S
D
D
T
M
I
D
T
I
C
A
N
S
D
V
I
A
K
-
V
T
L
A
P
E
N
N
K
-
P
-
E
H
I
E
K
L
V
K
A
G
I
V
V
S
I
G
H
T
N
A
T
Y
S
E
A
R
K
S
F
E
S
G
I
T
F
A
T
H
L
F
N
A
M
T
P
M
V
G
R
E
P
G
V
V
G
A
I
Y
D
T
P
E
V
Y
A
G
I
I
A
D
G
F
H
V
D
Y
A
N
I
R
I
A
H
K
I
-
K
G
---
E
K
L
V
L
V
T
D
A
T
A
P
A
-
G
A
E
M
D
Y
F
I
F
V
G
K
K
V
Y
Y
R
D
G
K
-----
C
----
V
D
-
E
N
G
T
L
G
---
G
S
A
L
T
M
I
E
A
V
Q
N
T
V
E
H
V
G
I
A
L
D
E
A
L
R
M
A
T
L
Y
P
A
K
A
I
G
V
D
E
K
L
G
R
I
K
K
G
M
I
A
N
L
T
V
F
D
R
D
F
N
V
K
A
T
V
V
N
G
------------
86
HHSearch
65.53
35%
-5
- C1 -
1O12
1
?
A:
[13-376]
----
M
I
V
E
K
V
L
I
V
D
P
I
D
G
E
F
-
T
G
D
V
E
I
E
E
G
K
I
V
K
V
E
--
K
R
E
----------
C
I
P
--
R
G
-
V
L
M
P
G
F
V
D
P
H
I
H
G
V
V
G
A
---
D
T
M
N
---------
C
D
F
S
E
M
E
E
F
L
Y
S
Q
G
V
T
T
F
L
A
T
T
V
S
T
S
L
E
K
M
K
E
I
L
R
K
A
R
D
Y
I
L
E
----
N
P
S
T
S
L
L
G
V
H
L
E
G
P
Y
I
S
K
E
K
K
G
A
H
S
E
K
H
I
R
P
-
P
S
E
R
E
L
S
E
I
D
----
S
P
A
K
M
L
T
F
A
P
E
I
E
S
-
S
-
E
L
L
L
R
L
V
K
R
D
I
V
L
S
A
G
H
S
I
A
T
F
E
E
F
M
K
F
Y
K
E
G
V
K
R
I
T
H
F
P
N
G
L
K
P
L
H
H
R
E
I
G
I
T
G
A
G
L
L
L
D
D
V
K
L
E
L
I
C
D
G
V
H
L
S
R
E
M
V
K
L
V
Y
K
V
-
K
K
A
NG
I
V
L
V
T
D
S
I
S
A
A
G
L
-
K
--
D
G
T
T
T
L
G
D
L
V
V
K
V
K
D
G
V
P
----
R
-----
L
-
E
D
G
T
L
A
---
G
S
T
L
F
F
S
Q
A
V
K
N
F
R
K
F
T
G
C
S
I
T
E
L
A
K
V
S
S
Y
N
S
C
V
E
L
G
L
D
-
D
R
G
R
I
A
E
G
T
R
A
D
L
V
L
L
D
E
D
L
N
V
V
M
T
I
K
E
G
E
V
V
F
R
S
R
-----
4
PsiBlast_PDB
65.52
31%
9
- C1 -
3IV8
3
NAGA_VIBCH
A:
[7-376]
------
L
T
N
C
K
I
Y
T
G
-
N
D
V
L
V
K
H
A
V
I
I
N
G
D
K
I
E
A
V
C
-----
P
I
-
E
S
L
P
S
E
M
N
V
V
DL
N
G
A
N
L
S
P
G
F
I
D
L
Q
L
N
G
C
G
G
V
---
M
F
N
D
-
E
I
T
----
A
E
T
I
D
T
M
H
K
A
N
L
K
S
G
C
T
S
F
L
P
T
L
I
T
S
S
D
E
N
M
R
Q
A
I
A
A
A
R
E
Y
Q
A
K
Y
P
N
-----
Q
S
L
G
L
H
L
E
G
P
Y
L
N
V
M
K
K
G
I
H
S
V
D
F
I
R
P
-
S
D
D
T
M
I
D
T
I
C
A
N
S
D
V
I
A
K
-
V
T
L
A
P
E
N
N
K
-
P
-
E
H
I
E
K
L
V
K
A
G
I
V
V
S
I
G
H
T
N
A
T
Y
S
E
A
R
K
S
F
E
S
G
I
T
F
A
T
H
L
F
N
A
M
T
P
M
V
G
R
E
P
G
V
V
G
A
I
Y
D
T
P
E
V
Y
A
G
I
I
A
D
G
F
H
V
D
Y
A
N
I
R
I
A
H
K
I
-
K
G
---
E
K
L
V
L
V
T
D
A
T
A
P
A
-
G
A
E
M
D
Y
F
I
F
V
G
K
K
V
Y
Y
R
D
G
K
-----
C
----
V
D
-
E
N
G
T
L
G
---
G
S
A
L
T
M
I
E
A
V
Q
N
T
V
E
H
V
G
I
A
L
D
E
A
L
R
M
A
T
L
Y
P
A
K
A
I
G
V
D
E
K
L
G
R
I
K
K
G
M
I
A
N
L
T
V
F
D
R
D
F
N
V
K
A
T
V
V
N
G
------------
29
PsiBlast_CBE
64.85
31%
12
- C1 -
2P53
3
NAGA_ECOLI
B:
[9-377]
-----------
I
F
T
G
-
H
E
F
L
D
D
H
A
V
V
I
A
D
G
L
I
K
S
V
C
PV
A
E
L
P
P
-
E
I
E
Q
R
S
L
N
G
-----
A
I
L
S
P
G
F
I
D
V
Q
L
N
G
C
G
G
V
QFN
D
T
A
E
-
A
V
S
----
V
E
T
L
E
I
M
Q
K
A
N
E
K
S
G
C
T
N
Y
L
P
T
L
I
T
T
S
D
E
L
M
K
Q
G
V
R
V
M
R
E
Y
L
A
K
H
P
N
-----
Q
A
L
G
L
H
L
E
G
P
W
L
N
L
V
K
K
G
T
H
N
P
N
F
V
R
K
-
P
D
A
A
L
V
D
-
F
L
C
E
N
A
D
V
I
T
K
V
T
L
A
P
E
M
V
P
-
A
-
E
V
I
S
K
L
A
N
A
G
I
V
V
S
A
G
H
S
N
A
T
L
K
E
A
K
A
G
F
R
A
G
I
T
F
A
T
H
L
Y
N
A
M
P
Y
I
T
G
R
E
P
G
L
A
G
A
I
L
D
E
A
D
I
Y
C
G
I
I
A
D
G
L
H
V
D
Y
A
N
I
R
N
A
K
R
L
-
K
G
D
---
K
L
C
L
V
T
N
A
T
A
P
A
-
G
A
N
I
E
Q
F
I
F
A
G
K
T
I
Y
Y
R
N
G
L
-----
C
----
V
D
-
E
N
G
T
L
S
---
G
S
S
L
T
M
I
E
G
V
R
N
L
V
E
H
C
G
I
A
L
D
E
V
L
R
M
A
T
L
Y
P
A
R
A
I
G
V
E
K
R
L
G
T
L
A
A
G
K
V
A
N
L
T
A
F
T
P
D
F
K
I
T
K
T
I
V
N
G
N
-----------
6
PsiBlast_PDB
64.62
31%
14
- C1 -
1YRR
4
NAGA_ECOLI
A:
[9-377]
-----------
I
F
T
G
-
H
E
F
L
D
D
H
A
V
V
I
A
D
G
L
I
K
S
V
C
P
V
A
E
L
P
P
-
E
I
E
Q
R
S
L
N
G
-----
A
I
L
S
P
G
F
I
D
V
Q
L
N
G
C
G
G
V
QFN
D
T
A
E
-
A
V
S
----
V
E
T
L
E
I
M
Q
K
A
N
E
K
S
G
C
T
N
Y
L
P
T
L
I
T
T
S
D
E
L
M
K
Q
G
V
R
V
M
R
E
Y
L
A
K
H
P
N
-----
Q
A
L
G
L
H
L
E
G
P
W
L
N
L
V
K
K
-
T
H
N
P
N
F
V
R
K
-
P
D
A
A
L
V
D
-
F
L
C
E
N
A
D
V
I
T
K
V
T
L
A
P
E
M
V
P
-
A
-
E
V
I
S
K
L
A
N
A
G
I
V
V
S
A
G
H
S
N
A
T
L
K
E
A
K
A
G
F
R
A
G
I
T
F
A
T
H
L
Y
N
A
M
P
Y
I
T
G
R
E
P
G
L
A
G
A
I
L
D
E
A
D
I
Y
C
G
I
I
A
D
G
L
H
V
D
Y
A
N
I
R
N
A
K
R
L
-
K
G
D
---
K
L
C
L
V
T
D
A
T
A
P
A
-
G
A
N
I
E
Q
F
I
F
A
G
K
T
I
Y
Y
R
N
G
L
-----
C
----
V
D
-
E
N
G
T
L
S
---
G
S
S
L
T
M
I
E
G
V
R
N
L
V
E
H
C
G
I
A
L
D
E
V
L
R
M
A
T
L
Y
P
A
R
A
I
G
V
E
K
R
L
G
T
L
A
A
G
K
V
A
N
L
T
A
F
T
P
D
F
K
I
T
K
T
I
V
N
G
N
-----------
25
PsiBlast_CBE
64.27
31%
5
- C1 -
3EGJ
2
NAGA_VIBCH
B:
[7-376]
------
L
T
N
C
K
I
Y
T
G
-
N
D
V
L
V
K
H
A
V
I
I
N
G
D
K
I
E
A
V
C
-----
P
I
-
E
S
L
P
S
E
M
N
V
V
D
L
N
G
A
N
L
S
P
G
F
I
D
L
Q
L
N
G
C
G
G
V
---
M
F
N
D
-
E
I
T
----
A
E
T
I
D
T
M
H
K
A
N
L
K
S
G
C
T
S
F
L
P
T
L
I
T
S
S
D
E
N
M
R
Q
A
I
A
A
A
R
E
Y
Q
A
K
Y
P
N
-----
Q
S
L
G
L
H
L
E
G
P
-------------------
D
D
T
M
I
D
T
I
C
A
N
S
D
V
I
A
K
-
V
T
L
A
P
E
N
N
K
-
P
-
E
H
I
E
K
L
V
K
A
G
I
V
V
S
I
G
H
T
N
A
T
Y
S
E
A
R
K
S
F
E
S
G
I
T
F
A
T
H
L
F
N
A
M
T
P
M
V
G
R
E
P
G
V
V
G
A
I
Y
D
T
P
E
V
Y
A
G
I
I
A
D
G
F
H
V
D
Y
A
N
I
R
I
A
H
K
I
-
K
G
---
E
K
L
V
L
V
T
D
A
T
A
P
A
-
G
A
E
M
D
Y
F
I
F
V
G
K
K
V
Y
Y
R
D
G
K
-----
C
----
V
D
-
E
N
G
T
L
G
---
G
S
A
L
T
M
I
E
A
V
Q
N
T
V
E
H
V
G
I
A
L
D
E
A
L
R
M
A
T
L
Y
P
A
K
A
I
G
V
D
E
K
L
G
R
I
K
K
G
M
I
A
N
L
T
V
F
D
R
D
F
N
V
K
A
T
V
V
N
G
------------
5
PsiBlast_PDB
64.26
31%
10
- C1 -
1YMY
-
NAGA_ECOLI
A:
[9-377]
-----------
I
F
T
G
-
H
E
F
L
D
D
H
A
V
V
I
A
D
G
L
I
K
S
V
C
P
V
A
E
L
P
P
-
E
I
E
Q
R
S
L
N
G
-----
A
I
L
S
P
G
F
I
D
V
Q
L
N
G
C
G
G
V
QFN
D
T
A
E
-
A
V
S
----
V
E
T
L
E
I
M
Q
K
A
N
E
K
S
G
C
T
N
Y
L
P
T
L
I
T
T
S
D
E
L
M
K
Q
G
V
R
V
M
R
E
Y
L
A
K
H
P
N
-----
Q
A
L
G
L
H
L
E
G
P
W
L
N
L
V
------
P
N
F
V
R
K
-
P
D
A
A
L
V
D
-
F
L
C
E
N
A
D
V
I
T
K
V
T
L
A
P
E
M
V
P
-
A
-
E
V
I
S
K
L
A
N
A
G
I
V
V
S
A
G
H
S
N
A
T
L
K
E
A
K
A
G
F
R
A
G
I
T
F
A
T
H
L
Y
N
A
M
P
Y
I
T
G
R
E
P
G
L
A
G
A
I
L
D
E
A
D
I
Y
C
G
I
I
A
D
G
L
H
V
D
Y
A
N
I
R
N
A
K
R
L
-
K
G
D
---
K
L
C
L
V
T
D
A
T
A
P
A
-
G
A
N
I
E
Q
F
I
F
A
G
K
T
I
Y
Y
R
N
G
L
-----
C
----
V
D
-
E
N
G
T
L
S
---
G
S
S
L
T
M
I
E
G
V
R
N
L
V
E
H
C
G
I
A
L
D
E
V
L
R
M
A
T
L
Y
P
A
R
A
I
G
V
E
K
R
L
G
T
L
A
A
G
K
V
A
N
L
T
A
F
T
P
D
F
K
I
T
K
T
I
V
N
G
N
-----------
8
PsiBlast_PDB
63.93
31%
14
- C1 -
2P53
3
NAGA_ECOLI
A:
[9-377]
-----------
I
F
T
G
-
H
E
F
L
D
D
H
A
V
V
I
A
D
G
L
I
K
S
V
C
PV
A
E
L
P
P
-
E
I
E
Q
R
S
L
N
G
-----
A
I
L
S
P
G
F
I
D
V
Q
L
N
G
C
G
G
V
QFN
D
T
A
E
-
A
V
S
----
V
E
T
L
E
I
M
Q
K
A
N
E
K
S
G
C
T
N
Y
L
P
T
L
I
T
T
S
D
E
L
M
K
Q
G
V
R
V
M
R
E
Y
L
A
K
H
P
N
-----
Q
A
L
G
L
H
L
E
G
P
W
L
N
L
V
K
K
G
T
H
N
P
N
F
V
R
K
-
P
D
A
A
L
V
D
-
F
L
C
E
N
A
D
V
I
T
K
V
T
L
A
P
E
M
V
P
-
A
-
E
V
I
S
K
L
A
N
A
G
I
V
V
S
A
G
H
S
N
A
T
L
K
E
A
K
A
G
F
R
A
G
I
T
F
A
T
H
L
Y
N
A
M
P
Y
I
T
G
R
E
P
G
L
A
G
A
I
L
D
E
A
D
I
Y
C
G
I
I
A
D
G
L
H
V
D
Y
A
N
I
R
N
A
K
R
L
-
K
G
D
---
K
L
C
L
V
T
N
A
T
A
P
A
-
G
A
N
I
E
Q
F
I
F
A
G
K
T
I
Y
Y
R
N
G
L
-----
C
----
V
D
-
E
N
G
T
L
S
---
G
S
S
L
T
M
I
E
G
V
R
N
L
V
E
H
C
G
I
A
L
D
E
V
L
R
M
A
T
L
Y
P
A
R
A
I
G
V
E
K
R
L
G
T
L
A
A
G
K
V
A
N
L
T
A
F
T
P
D
F
K
I
T
K
T
I
V
N
G
N
-----------
22
PsiBlast_CBE
63.48
31%
1
- C1 -
3IV8
3
NAGA_VIBCH
D:
[7-376]
------
L
T
N
C
K
I
Y
T
G
-
N
D
V
L
V
K
H
A
V
I
I
N
G
D
K
I
E
A
V
C
-----
P
I
-
E
S
L
P
S
E
M
N
V
V
DL
N
G
A
N
L
S
P
G
F
I
D
L
Q
L
N
G
C
G
G
V
---
M
F
N
D
-
E
I
T
----
A
E
T
I
D
T
M
H
K
A
N
L
K
S
G
C
T
S
F
L
P
T
L
I
T
S
S
D
E
N
M
R
Q
A
I
A
A
A
R
E
Y
Q
A
K
Y
P
N
-----
Q
S
L
G
L
H
L
E
G
P
Y
L
N
V
M
K
K
G
I
H
S
V
D
F
I
R
P
-
S
D
D
T
M
I
D
T
I
C
A
N
S
D
V
I
A
K
-
V
T
L
A
P
E
N
N
K
-
P
-
E
H
I
E
K
L
V
K
A
G
I
V
V
S
I
G
H
T
N
A
T
Y
S
E
A
R
K
S
F
E
S
G
I
T
F
A
T
H
L
F
N
A
M
T
P
M
V
G
R
E
P
G
V
V
G
A
I
Y
D
T
P
E
V
Y
A
G
I
I
A
D
G
F
H
V
D
Y
A
N
I
R
I
A
H
K
I
-
K
G
---
E
K
L
V
L
V
T
D
A
T
A
P
A
-
G
A
E
M
---------------------------------
L
G
---
G
S
A
L
T
M
I
E
A
V
Q
N
T
V
E
H
V
G
I
A
L
D
E
A
L
R
M
A
T
L
Y
P
A
K
A
I
G
V
D
E
K
L
G
R
I
K
K
G
M
I
A
N
L
T
V
F
D
R
D
F
N
V
K
A
T
V
V
N
G
------------
7
PsiBlast_PDB
62.87
31%
14
- C1 -
2P50
1
NAGA_ECOLI
A:
[9-377]
-----------
I
F
T
G
-
H
E
F
L
D
D
H
A
V
V
I
A
D
G
L
I
K
S
V
C
P
V
A
E
L
P
P
-
E
I
E
Q
R
S
L
N
G
-----
A
I
L
S
P
G
F
I
D
V
Q
L
N
G
C
G
G
V
QFN
D
T
A
E
-
A
V
S
----
V
E
T
L
E
I
M
Q
K
A
N
E
K
S
G
C
T
N
Y
L
P
T
L
I
T
T
S
D
E
L
M
K
Q
G
V
R
V
M
R
E
Y
L
A
K
H
P
N
-----
Q
A
L
G
L
H
L
E
G
P
W
L
N
L
V
K
K
G
T
H
N
P
N
F
V
R
K
-
P
D
A
A
L
V
D
-
F
L
C
E
N
A
D
V
I
T
K
V
T
L
A
P
E
M
V
P
-
A
-
E
V
I
S
K
L
A
N
A
G
I
V
V
S
A
G
H
S
N
A
T
L
K
E
A
K
A
G
F
R
A
G
I
T
F
A
T
H
L
Y
N
A
M
P
Y
I
T
G
R
E
P
G
L
A
G
A
I
L
D
E
A
D
I
Y
C
G
I
I
A
D
G
L
H
V
D
Y
A
N
I
R
N
A
K
R
L
-
K
G
D
---
K
L
C
L
V
T
D
A
T
A
P
A
-
G
A
N
I
E
Q
F
I
F
A
G
K
T
I
Y
Y
R
N
G
L
-----
C
----
V
D
-
E
N
G
T
L
S
---
G
S
S
L
T
M
I
E
G
V
R
N
L
V
E
H
C
G
I
A
L
D
E
V
L
R
M
A
T
L
Y
P
A
R
A
I
G
V
E
K
R
L
G
T
L
A
A
G
K
V
A
N
L
T
A
F
T
P
D
F
K
I
T
K
T
I
V
N
G
N
-----------
27
PsiBlast_CBE
60.51
31%
21
- C1 -
2P50
1
NAGA_ECOLI
C:
[9-377]
-----------
I
F
T
G
-
H
E
F
L
D
D
H
A
V
V
I
A
D
G
L
I
K
S
V
C
P
V
A
E
L
P
P
-
E
I
E
Q
R
S
L
N
G
-----
A
I
L
S
P
G
F
I
D
V
Q
L
N
G
C
G
G
V
QFN
D
T
A
E
-
A
V
S
----
V
E
T
L
E
I
M
Q
K
A
N
E
K
S
G
C
T
N
Y
L
P
T
L
I
T
T
S
D
E
L
M
K
Q
G
V
R
V
M
R
E
Y
L
A
K
H
P
N
-----
Q
A
L
G
L
H
L
E
G
P
W
L
N
L
V
K
K
G
T
H
N
P
N
F
V
R
K
-
P
D
A
A
L
V
D
-
F
L
C
E
N
A
D
V
I
T
K
V
T
L
A
P
E
M
V
P
-
A
-
E
V
I
S
K
L
A
N
A
G
I
V
V
S
A
G
H
S
N
A
T
L
K
E
A
K
A
G
F
R
A
G
I
T
F
A
T
H
L
Y
N
A
M
P
Y
I
T
G
R
E
P
G
L
A
G
A
I
L
D
E
A
D
I
Y
C
G
I
I
A
D
G
L
H
V
D
Y
A
N
I
R
N
A
K
R
L
-
K
G
D
---
K
L
C
L
V
T
D
A
T
A
P
A
-
G
A
----------------------------------------
G
S
S
L
T
M
I
E
G
V
R
N
L
V
E
H
C
G
I
A
L
D
E
V
L
R
M
A
T
L
Y
P
A
R
A
I
G
V
E
K
R
L
G
T
L
A
A
G
K
V
A
N
L
T
A
F
T
P
D
F
K
I
T
K
T
I
V
N
G
N
-----------
28
PsiBlast_CBE
59.79
31%
19
- C1 -
2P50
1
NAGA_ECOLI
B:
[9-377]
-----------
I
F
T
G
-
H
E
F
L
D
D
H
A
V
V
I
A
D
G
L
I
K
S
V
C
PV
A
E
L
P
P
-
E
I
E
Q
R
S
L
N
G
-----
A
I
L
S
P
G
F
I
D
V
Q
L
N
G
C
G
G
V
QFN
D
T
A
E
-
A
V
S
----
V
E
T
L
E
I
M
Q
K
A
N
E
K
S
G
C
T
N
Y
L
P
T
L
I
T
T
S
D
E
L
M
K
Q
G
V
R
V
M
R
E
Y
L
A
K
H
P
N
-----
Q
A
L
G
L
H
L
E
G
P
W
L
N
L
V
K
K
G
T
H
N
P
N
F
V
R
K
-
P
D
A
A
L
V
D
-
F
L
C
E
N
A
D
V
I
T
K
V
T
L
A
P
E
M
V
P
-
A
-
E
V
I
S
K
L
A
N
A
G
I
V
V
S
A
G
H
S
N
A
T
L
K
E
A
K
A
G
F
R
A
G
I
T
F
A
T
H
L
Y
N
A
M
P
Y
I
T
G
R
E
P
G
L
A
G
A
I
L
D
E
A
D
I
Y
C
G
I
I
A
D
G
L
H
V
D
Y
A
N
I
R
N
A
K
R
L
-
K
G
D
---
K
L
C
L
V
T
D
A
T
A
P
A
-
G
A
------------------------------------
S
---
G
S
S
L
T
M
I
E
G
V
R
N
L
V
E
H
C
G
I
A
L
D
E
V
L
R
M
A
T
L
Y
P
A
R
A
I
G
V
E
K
R
L
G
T
L
A
A
G
K
V
A
N
L
T
A
F
T
P
D
F
K
I
T
K
T
I
V
N
G
N
-----------