@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu35160: (2016-07-29 )
MAMDRIEVKGARAHNLKNIDVTIPRDQLVVVTGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQMDKPDVDAIEGLSPAISIDQKTTSRNPRSTVGTVTEIYDYLRLLYARVGKPHCPEHGIEITSQTIEQMVDRILEYPERTKLQVLAPIVSGRKGAHVKVLEQIRKQGYVRVRIDGEMAELSDDIELEKNKKHSIEVVIDRIVVKEGVAARLSDSLETALRLGEGRVMIDVIGEEELMFSEHHACPHCGFSIGELEPRLFSFNSPFGACPTCDGLGMKLEVDADLVIPNQDLSLKENAVAPWTPISSQYYPQLLEAVCTHYGIDMDVPVKDLPKHQLDKVLYGSGDDLIYFRYENDFGQIREGEIQFEGVLRNIERRYKETGSDFIREQMEQYMSQKSCPTCKGYRLKKEALAVLIDGRHIGKITELSVADALAFFKDLTLSEKDMQIANLILREIVERLSFLDKVGLDYLTLSRAAGTLSGGEAQRIRLATQIGSRLSGVLYILDEPSIGLHQRDNDRLISALKNMRDLGNTLIVVEHDEDTMMAADYLIDIGPGAGIHGGQVISAGTPEEVMEDPNSLTGSYLSGKKFIPLPPERRKPDGRYIEIKGASENNLKKVNAKFPLGTFTAVTGVSGSGKSTLVNEILHKALAQKLHKAKAKPGSHKEIKGLDHLDKVIDIDQAPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKVRGYKKGRFSFNVKGGRCEACRGDGIIKIEMHFLPDVYVPCEVCHGKRYNRETLEVTYKGKSISDVLDMTVEDALSFFENIPKIKRKLQTLYDVGLGYITLGQPATTLSGGEAQRVKLASELHKRSTGRTLYILDEPTTGLHVDDIARLLVVLQRLVDNGDTVLVIEHNLDIIKTADYIVDLGPEGGAGGGTIVASGTPEEITEVEESYTGRYLKPVIERDKTRMKSLLKAKETATS
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80--.........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240--........250...-....260.......270.......280.......290.......300.......310...-.....320.......330.......340.......350....-----...360------........370......----.380.----......390.......400.......410.......420...--------....430.......440.....----------..450-.---------.......--.460.......470.......480.......490.......500....-...510.......520.......530.......540.......550.......560.......570.......580.......590.......600..-.....610........620.......630.......640.......650.......660.------------...----------...670....-...680.......690.......700.......710.......720--------------------------------------------------------------------------------------------------------------------------------------.........730.......740.......-750--------------------------------------------------------------------------------------------------------...--....760.......770.......780------.........790.......800--------------.......810.......820.......830.......840.......850.......860.......870......-.880.......890..-.....900.......910.......920.......930.......940.......950.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAM
D
R
I
E
VKGARAHNL
K
N
I
D
V
T
IPRD
Q
L
V
V
V
TGLSGSGKS
S
L
A
F
D
T
I
Y
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
GQMDKPD
V
D
A
IEG---LSP
A
I
S
IDQKTTSRNPRSTVG
T
V
T
E
I
Y
D
Y
L
R
L
L
Y
A
RVGKPHCPEHG
I
E
I
T
S
Q
T
I
E
Q
M
V
D
R
I
LEYPERT
K
L
Q
V
L
A
P
I
VSGRKG
A
H
V
K
V
L
E
Q
I
R
KQ
G
Y
V
R
V
R
IDG
E
M
A
ELSDD
I
E
LEKNKK
H
S
I
E
V
V
I
D
R
I
V
V
K
E
G
V
A
A
R
L
S
D
S
L
E
T
A
L
R
LGE
G
R
V
M
I
D
V
IGE---E
E
L
M
FSEHHACPHC-GFSIGELE
P
R
L
FSFNSPFGACPTCDGLG
M
K
L
E
VDA
D
L
V
IPNQDLSLKENAVAPWTP-IS
S
-
Q
Y
Y
P
Q
L
L
E
A
V
C
T
HYGIDMDVPVKDL
P
K
H
Q
L
D
K
V
LYGSGD
D
L
I
-----
Y
F
R
YE-------NDFGQIREG
E
I
Q
F
E
G
V
L
----
R
N
I
E
R
----
R
Y
K
ET
G
S
D
F
I
R
E
Q
M
E
Q
Y
M
S
QKSCPTCKGY
R
L
K
K
E
A
L
A
V
L
IDG--------RHIGK
I
T
E
L
S
V
A
D
A
L
A
F
F
K
DLT----------LS
E
---
K
---------
D
M
Q
I
A
N
L
--
I
L
R
E
I
V
E
R
L
S
F
L
D
K
VGLD
Y
L
T
LSRAAGTLSGGE
A
Q
R
I
R
L
A
T
Q
I
G
S
RLS-
G
V
L
Y
I
LDEPSIGLHQRD
N
D
R
L
I
S
A
L
K
N
M
R
D
LG
N
T
L
I
V
V
EHDED
T
M
M
A
A
D
Y
L
I
DIGPGAGIHG
G
Q
V
ISAG
T
P
E
E
V
MEDPNSLTGSYLSGKKFIPLPPER-RKPDG
R
-
Y
I
E
I
KGASENN
L
K
K
VNAKFPLG
T
F
T
A
V
TGVSGS
G
K
S
T
L
V
N
E
I
L
H
K
A
L
A
Q
K
L
H
K
------------AKA----------KPGSHKEIK
G
-
L
D
H
L
D
K
V
IDIDQAPIGRTPRSNPATYT
G
V
F
D
D
I
R
D
V
F
AQTN
E
A
K
----------------------------------------------------------------------------------------------------------------------------------------
V
R
G
Y
KKG
R
F
S
F
NVKG
G
R
C
E
ACRGD
G
I
I
K
I
-
E
M
H
--------------------------------------------------------------------------------------------------------FLP--DVYV
P
C
E
VCHGKRYNR
E
T
L
E
V
T
YKG--------K
S
I
S
D
V
L
D
M
T
V
E
D
A
L
S
F
F
E
N
I
P
--------------
K
I
K
R
K
L
Q
T
L
Y
D
VGL
G
Y
I
TLGQPATTLSGG
E
A
Q
R
V
K
L
A
S
E
L
H
KRSTG
R
T
L
Y
I
LDEPTTGL
H
V
D
D
I
A
R
L
L
V
V
L
Q
R
L
VD-NG
D
T
V
L
V
I
EHNL
D
I
I
K
-TA
D
Y
I
V
DLGPEGGAGG
G
T
I
V
ASG
T
P
E
E
I
T
E
V
E
E
SYTG
R
Y
L
K
P
V
I
E
R
D
K
T
R
M
K
S
L
L
K
A
K
ETATS
1
PsiBlast_PDB
87.86
82%
-92
- C2 -
3UWX
3
?
A:
[21-969]
--
M
D
K
I
I
V
K
G
A
R
A
H
N
L
K
N
I
D
V
E
I
P
R
G
K
L
V
V
L
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
Y
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
E
K
P
D
V
D
A
I
E
G
---
L
S
P
A
I
S
I
D
Q
K
T
T
S
R
N
P
R
S
T
V
G
T
V
T
E
I
Y
D
Y
L
R
L
L
F
A
R
I
G
R
P
I
C
P
T
H
G
I
E
I
Q
S
Q
T
I
E
Q
M
V
D
R
L
L
S
Y
P
E
R
T
K
M
Q
I
L
A
P
I
V
S
G
K
K
G
T
H
A
K
T
L
E
D
I
R
K
Q
G
Y
V
R
V
R
I
D
R
E
M
R
E
L
T
G
D
I
E
L
E
K
N
K
K
H
S
I
D
V
V
V
D
R
I
I
I
K
D
G
I
A
A
R
L
A
D
S
L
E
T
A
L
K
L
A
D
G
K
V
V
V
D
V
I
G
E
---
G
E
L
L
F
S
E
K
H
A
C
P
Y
C
-
G
F
S
I
G
E
L
E
P
R
L
F
S
F
N
S
P
F
G
A
C
P
D
C
D
G
L
G
A
K
L
E
V
D
L
D
L
V
I
P
N
D
E
L
T
L
K
E
H
A
I
A
P
W
E
P
------
Y
Y
P
Q
L
L
E
A
V
C
R
H
Y
G
I
P
M
D
V
P
V
K
D
L
P
K
E
Q
L
D
K
I
L
Y
G
S
G
G
E
P
I
-----
Y
F
R
Y
T
-------
N
D
F
G
Q
V
R
E
Q
Y
I
A
F
E
G
V
I
----
P
N
V
E
R
----
R
Y
R
E
T
S
S
D
Y
I
R
E
Q
M
E
K
Y
M
A
E
Q
P
C
P
T
C
Q
G
Y
R
L
K
K
E
S
L
A
V
L
V
G
G
--------
K
H
I
G
E
V
T
A
M
S
V
T
E
A
L
A
F
F
D
G
L
E
----------
L
T
E
---
K
---------
E
A
Q
I
A
R
L
--
I
L
R
E
I
R
D
R
L
G
F
L
Q
N
V
G
L
D
Y
L
T
L
S
R
S
A
G
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
R
L
T
-
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
D
R
L
I
A
T
L
K
S
M
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
M
L
A
A
D
Y
L
I
D
I
G
P
G
A
G
I
H
G
G
E
V
V
A
A
G
T
P
E
E
V
M
N
D
P
N
S
L
T
G
Q
Y
L
S
G
K
K
F
I
P
I
P
A
E
R
-
R
R
P
D
G
R
-
W
L
E
V
V
G
A
R
E
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
Y
K
A
L
A
Q
K
L
H
R
------------
A
K
A
----------
K
P
G
E
H
R
D
I
R
G
-
L
E
H
L
D
K
V
I
D
I
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
D
I
R
D
V
F
A
S
T
N
E
A
K
----------------------------------------------------------------------------------------------------------------------------------------
V
R
G
Y
K
K
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
H
G
D
G
I
I
K
I
-
E
M
H
--------------------------------------------------------------------------------------------------------
F
L
P
--
D
V
Y
V
P
C
E
V
C
H
G
K
R
Y
N
R
E
T
L
E
V
T
Y
K
G
--------
K
N
I
A
E
V
L
D
M
T
V
E
D
A
L
D
F
F
A
S
I
P
--------------
K
I
K
R
K
L
E
T
L
Y
D
V
G
L
G
Y
M
K
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
S
N
G
R
T
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
A
R
L
L
D
V
L
H
R
L
V
D
-
N
G
D
T
V
L
V
I
E
H
N
L
D
V
I
K
-
T
A
D
Y
I
I
D
L
G
P
E
G
G
D
R
G
G
Q
I
V
A
V
G
T
P
E
E
V
A
E
V
K
E
S
H
T
G
R
Y
L
K
P
I
L
E
R
D
R
A
R
M
Q
A
R
Y
E
A
------
110
HHSearch
84.29
82%
-90
- C2 -
2R6F
5
?
A:
[21-966]
--
M
D
K
I
I
V
K
G
A
R
A
H
N
L
K
N
I
D
V
E
I
P
R
G
K
L
V
V
L
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
Y
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
E
K
P
D
V
D
A
I
E
G
---
L
S
P
A
I
S
I
D
Q
K
T
T
S
R
N
P
R
S
T
V
G
T
V
T
E
I
Y
D
Y
L
R
L
L
F
A
R
I
G
R
P
I
C
P
T
H
G
I
E
I
Q
S
Q
T
I
E
Q
M
V
D
R
L
L
S
Y
P
E
R
T
K
M
Q
I
L
A
P
----------------------------------------------
I
D
V
V
V
D
R
I
I
I
K
D
G
I
A
A
R
L
A
D
S
L
E
T
A
L
K
L
A
D
G
K
V
V
V
D
V
I
G
E
---
G
E
L
L
F
S
E
K
H
A
C
P
Y
C
-
G
F
S
I
G
E
L
E
P
R
L
F
S
F
N
S
P
F
G
A
C
P
D
C
D
G
L
G
A
K
L
E
V
D
L
D
L
V
I
P
N
D
E
L
T
L
K
E
H
A
I
A
P
W
E
P
------
Y
Y
P
Q
L
L
E
A
V
C
R
H
Y
G
I
P
M
D
V
P
V
K
D
L
P
K
E
Q
L
D
K
I
L
Y
G
S
G
G
E
P
I
-----
Y
F
R
Y
T
-------
N
D
F
G
Q
V
R
E
Q
Y
I
A
F
E
G
V
I
----
P
N
V
E
R
----
R
Y
R
E
T
S
S
D
Y
I
R
E
Q
M
E
K
Y
M
A
E
Q
P
C
P
T
C
Q
G
Y
R
L
K
K
E
S
L
A
V
L
V
G
G
--------
K
H
I
G
E
V
T
A
M
S
V
T
E
A
L
A
F
F
D
G
L
E
----------
L
T
E
---
K
---------
E
A
Q
I
A
R
L
--
I
L
R
E
I
R
D
R
L
G
F
L
Q
N
V
G
L
D
Y
L
T
L
S
R
S
A
G
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
R
L
T
-
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
D
R
L
I
A
T
L
K
S
M
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
M
L
A
A
D
Y
L
I
D
I
G
P
G
A
G
I
H
G
G
E
V
V
A
A
G
T
P
E
E
V
M
N
D
P
N
S
L
T
G
Q
Y
L
S
G
K
K
F
I
P
I
P
A
E
R
-
R
R
P
D
G
R
-
W
L
E
V
V
G
A
R
E
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
Y
K
A
L
A
Q
K
L
H
R
------------
A
K
A
----------
K
P
G
E
H
R
D
I
R
G
-
L
E
H
L
D
K
V
I
D
I
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
D
I
R
D
V
F
A
S
T
N
E
A
K
----------------------------------------------------------------------------------------------------------------------------------------
V
R
G
Y
K
K
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
H
G
D
G
I
I
K
I
-
E
M
H
--------------------------------------------------------------------------------------------------------
F
L
P
--
D
V
Y
V
P
C
E
V
C
H
G
K
R
Y
N
R
E
T
L
E
V
T
Y
K
G
--------
K
N
I
A
E
V
L
D
M
T
V
E
D
A
L
D
F
F
A
S
I
P
--------------
K
I
K
R
K
L
E
T
L
Y
D
V
G
L
G
Y
M
K
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
S
N
G
R
T
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
A
R
L
L
D
V
L
H
R
L
V
D
-
N
G
D
T
V
L
V
I
E
H
N
L
D
V
I
K
-
T
A
D
Y
I
I
D
L
G
P
E
G
G
D
R
G
G
Q
I
V
A
V
G
T
P
E
E
V
A
E
V
K
E
S
H
T
G
R
Y
L
K
P
I
L
E
R
D
R
A
R
M
Q
A
R
---------
2
PsiBlast_PDB
83.68
80%
-90
- C2 -
2R6F
5
?
A:
[22-969]
---
D
K
I
I
V
K
G
A
R
A
H
N
L
K
N
I
D
V
E
I
P
R
G
K
L
V
V
L
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
Y
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
E
K
P
D
V
D
A
I
E
G
---
L
S
P
A
I
S
I
D
Q
K
T
T
S
R
N
P
R
S
T
V
G
T
V
T
E
I
Y
D
Y
L
R
L
L
F
A
R
I
G
R
P
I
C
P
T
H
G
I
E
I
Q
S
Q
T
I
E
Q
M
V
D
R
L
L
S
Y
P
E
R
T
K
M
Q
I
L
A
P
----------------------------------------------
I
D
V
V
V
D
R
I
I
I
K
D
G
I
A
A
R
L
A
D
S
L
E
T
A
L
K
L
A
D
G
K
V
V
V
D
V
I
G
E
---
G
E
L
L
F
S
E
K
H
A
C
P
Y
C
-
G
F
S
I
G
E
L
E
P
R
L
F
S
F
N
S
P
F
G
A
C
P
D
C
D
G
L
G
A
K
L
E
V
D
L
D
L
V
I
P
N
D
E
L
T
L
K
E
H
A
I
A
P
W
E
P
------
Y
Y
P
Q
L
L
E
A
V
C
R
H
Y
G
I
P
M
D
V
P
V
K
D
L
P
K
E
Q
L
D
K
I
L
Y
G
S
G
G
E
P
I
-----
Y
F
R
Y
T
-------
N
D
F
G
Q
V
R
E
Q
Y
I
A
F
E
G
V
I
----
P
N
V
E
R
----
R
Y
R
E
T
S
S
D
Y
I
R
E
Q
M
E
K
Y
M
A
E
Q
P
C
P
T
C
Q
G
Y
R
L
K
K
E
S
L
A
V
L
V
G
G
--------
K
H
I
G
E
V
T
A
M
S
V
T
E
A
L
A
F
F
D
G
L
E
----------
L
T
E
---
K
---------
E
A
Q
I
A
R
L
--
I
L
R
E
I
R
D
R
L
G
F
L
Q
N
V
G
L
D
Y
L
T
L
S
R
S
A
G
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
R
L
T
-
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
D
R
L
I
A
T
L
K
S
M
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
M
L
A
A
D
Y
L
I
D
I
G
P
G
A
G
I
H
G
G
E
V
V
A
A
G
T
P
E
E
V
M
N
D
P
N
S
L
T
G
Q
Y
L
S
G
K
K
F
I
P
I
P
A
E
R
-
R
R
P
D
G
R
-
W
L
E
V
V
G
A
R
E
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
Y
K
A
L
A
Q
K
L
H
R
------------
A
K
A
----------
K
P
G
E
H
R
D
I
R
G
-
L
E
H
L
D
K
V
I
D
I
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
D
I
R
D
V
F
A
S
T
N
E
A
K
----------------------------------------------------------------------------------------------------------------------------------------
V
R
G
Y
K
K
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
H
G
D
G
I
I
K
I
-
E
M
H
--------------------------------------------------------------------------------------------------------
F
L
P
--
D
V
Y
V
P
C
E
V
C
H
G
K
R
Y
N
R
E
T
L
E
V
T
Y
K
G
--------
K
N
I
A
E
V
L
D
M
T
V
E
D
A
L
D
F
F
A
S
I
P
--------------
K
I
K
R
K
L
E
T
L
Y
D
V
G
L
G
Y
M
K
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
S
N
G
R
T
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
A
R
L
L
D
V
L
H
R
L
V
D
-
N
G
D
T
V
L
V
I
E
H
N
L
D
V
I
K
-
T
A
D
Y
I
I
D
L
G
P
E
G
G
D
R
G
G
Q
I
V
A
V
G
T
P
E
E
V
A
E
V
K
E
S
H
T
G
R
Y
L
K
P
I
L
E
R
D
R
A
R
M
Q
A
R
Y
E
A
------
107
HHSearch
71.30
60%
-6
- C2 -
3ZQJ
3
UVRA_MYCTU
A:
[23-974]
--
A
D
R
L
I
V
K
G
A
R
E
H
N
L
R
S
V
D
L
D
L
P
R
D
A
L
I
V
F
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
F
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
D
K
P
D
V
D
F
I
E
G
---
L
S
P
A
V
S
I
D
Q
K
S
T
N
R
N
P
R
S
T
V
G
T
I
T
E
V
Y
D
Y
L
R
L
L
Y
A
R
A
G
T
P
H
C
P
T
C
G
E
R
V
A
R
Q
T
P
Q
Q
I
V
D
Q
V
L
A
M
P
E
G
T
R
F
L
V
L
A
P
V
V
R
T
R
K
G
E
F
A
D
L
F
D
K
L
N
A
Q
G
Y
S
R
V
R
V
D
G
V
V
H
P
L
T
D
P
P
K
L
K
K
Q
E
K
H
D
I
E
V
V
V
D
R
L
T
V
K
A
A
A
K
R
R
L
T
D
S
V
E
T
A
L
N
L
A
D
G
I
V
V
L
E
F
V
D
-----
E
Q
R
F
S
E
K
L
A
C
P
N
G
H
A
L
A
V
D
D
L
E
P
R
S
F
S
F
N
S
P
Y
G
A
C
P
E
C
S
G
L
G
I
R
K
E
V
D
P
E
L
V
V
P
D
P
D
R
T
L
A
Q
G
A
V
A
P
W
S
N
-
G
H
T
A
E
Y
F
T
R
M
M
A
G
L
G
E
A
L
G
F
D
V
D
T
P
W
R
K
L
P
A
K
A
R
K
A
I
L
E
G
A
D
E
Q
V
H
------
V
R
Y
R
-------
N
R
Y
G
R
T
R
S
Y
Y
A
D
F
E
G
V
L
----
A
F
L
Q
R
----
K
M
S
Q
T
E
S
E
Q
M
K
E
R
Y
E
G
F
M
R
D
V
P
C
P
V
C
A
G
T
R
L
K
P
E
I
L
A
V
T
L
A
G
E
SKGEH
G
A
K
S
I
A
E
V
C
E
L
S
I
A
D
C
A
D
F
L
N
A
L
T
----------
L
G
P
---
R
---------
E
Q
A
I
A
G
Q
--
V
L
K
E
I
R
S
R
L
G
F
L
L
D
V
G
L
E
Y
L
S
L
S
R
A
A
A
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
G
L
V
-
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
R
R
L
I
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T
L
T
R
L
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
I
E
H
A
D
W
I
V
D
I
G
P
G
A
G
E
H
G
G
R
I
V
H
S
G
P
Y
D
E
L
L
R
N
K
D
S
I
T
G
A
Y
L
S
G
R
E
S
I
E
I
P
A
I
R
R
S
V
D
P
R
R
-
Q
L
T
V
V
G
A
R
E
H
N
L
R
G
I
D
V
S
F
P
L
G
V
L
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
N
D
I
L
A
A
V
L
A
N
R
L
N
G
------------
A
R
Q
----------
V
P
G
R
H
T
R
V
T
G
-
L
D
Y
L
D
K
L
V
R
V
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
K
I
R
T
L
F
A
A
T
T
E
A
K
----------------------------------------------------------------------------------------------------------------------------------------
V
R
G
Y
Q
P
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
T
G
D
G
T
I
K
I
-
E
M
N
--------------------------------------------------------------------------------------------------------
F
L
P
--
D
V
Y
V
P
C
E
V
C
Q
G
A
R
Y
N
R
E
T
L
E
V
H
Y
K
G
--------
K
T
V
S
E
V
L
D
M
S
I
E
E
A
A
E
F
F
E
P
I
A
--------------
G
V
H
R
Y
L
R
T
L
V
D
V
G
L
G
Y
V
R
L
G
Q
P
A
P
T
L
S
G
G
E
A
Q
R
V
K
L
A
S
E
L
Q
K
R
S
T
G
R
T
V
Y
I
L
D
E
P
T
T
G
L
H
F
D
D
I
R
K
L
L
N
V
I
N
G
L
V
D
-
K
G
N
T
V
I
V
I
E
H
N
L
D
V
I
K
-
T
S
D
W
I
I
D
L
G
P
E
G
G
A
G
G
G
T
V
V
A
Q
G
T
P
E
D
V
A
A
V
P
A
S
Y
T
G
K
F
L
A
E
V
V
-------------------
3
PsiBlast_PDB
70.92
59%
-6
- C2 -
3ZQJ
3
UVRA_MYCTU
A:
[24-974]
---
D
R
L
I
V
K
G
A
R
E
H
N
L
R
S
V
D
L
D
L
P
R
D
A
L
I
V
F
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
F
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
D
K
P
D
V
D
F
I
E
G
---
L
S
P
A
V
S
I
D
Q
K
S
T
N
R
N
P
R
S
T
V
G
T
I
T
E
V
Y
D
Y
L
R
L
L
Y
A
R
A
G
T
P
H
C
P
T
C
G
E
R
V
A
R
Q
T
P
Q
Q
I
V
D
Q
V
L
A
M
P
E
G
T
R
F
L
V
L
A
P
V
V
R
T
R
K
G
E
F
A
D
L
F
D
K
L
N
A
Q
G
Y
S
R
V
R
V
D
G
V
V
H
P
L
T
D
P
P
K
L
K
K
Q
E
K
H
D
I
E
V
V
V
D
R
L
T
V
K
A
A
A
K
R
R
L
T
D
S
V
E
T
A
L
N
L
A
D
G
I
V
V
L
E
F
V
D
-----
E
Q
R
F
S
E
K
L
A
C
P
N
G
H
A
L
A
V
D
D
L
E
P
R
S
F
S
F
N
S
P
Y
G
A
C
P
E
C
S
G
L
G
I
R
K
E
V
D
P
E
L
V
V
P
D
P
D
R
T
L
A
Q
G
A
V
A
P
W
S
N
G
H
T
A
-
E
Y
F
T
R
M
M
A
G
L
G
E
A
L
G
F
D
V
D
T
P
W
R
K
L
P
A
K
A
R
K
A
I
L
E
G
A
-
D
E
Q
V
-----
H
V
R
Y
R
-------
N
R
Y
G
R
T
R
S
Y
Y
A
D
F
E
G
V
L
----
A
F
L
Q
R
----
K
M
S
Q
T
E
S
E
Q
M
K
E
R
Y
E
G
F
M
R
D
V
P
C
P
V
C
A
G
T
R
L
K
P
E
I
L
A
V
T
L
A
G
E
SKGEH
G
A
K
S
I
A
E
V
C
E
L
S
I
A
D
C
A
D
F
L
N
A
L
T
----------
L
G
P
---
R
---------
E
Q
A
I
A
G
Q
--
V
L
K
E
I
R
S
R
L
G
F
L
L
D
V
G
L
E
Y
L
S
L
S
R
A
A
A
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
G
L
V
-
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
R
R
L
I
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T
L
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R
L
R
D
L
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N
T
L
I
V
V
E
H
D
E
D
T
I
E
H
A
D
W
I
V
D
I
G
P
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A
G
E
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R
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V
H
S
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Y
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E
L
L
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N
K
D
S
I
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Y
L
S
G
R
E
S
I
E
I
P
A
I
R
-
R
S
V
D
P
R
R
Q
L
T
V
V
G
A
R
E
H
N
L
R
G
I
D
V
S
F
P
L
G
V
L
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
N
D
I
L
A
A
V
L
A
N
R
L
N
G
------------
A
R
Q
----------
V
P
G
R
H
T
R
V
T
G
-
L
D
Y
L
D
K
L
V
R
V
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
K
I
R
T
L
F
A
A
T
T
E
A
K
----------------------------------------------------------------------------------------------------------------------------------------
V
R
G
Y
Q
P
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
T
G
D
G
T
I
K
I
-
E
M
N
--------------------------------------------------------------------------------------------------------
F
L
P
--
D
V
Y
V
P
C
E
V
C
Q
G
A
R
Y
N
R
E
T
L
E
V
H
Y
K
G
--------
K
T
V
S
E
V
L
D
M
S
I
E
E
A
A
E
F
F
E
P
I
A
--------------
G
V
H
R
Y
L
R
T
L
V
D
V
G
L
G
Y
V
R
L
G
Q
P
A
P
T
L
S
G
G
E
A
Q
R
V
K
L
A
S
E
L
Q
K
R
S
T
G
R
T
V
Y
I
L
D
E
P
T
T
G
L
H
F
D
D
I
R
K
L
L
N
V
I
N
G
L
V
D
-
K
G
N
T
V
I
V
I
E
H
N
L
D
V
I
K
-
T
S
D
W
I
I
D
L
G
P
E
G
G
A
G
G
G
T
V
V
A
Q
G
T
P
E
D
V
A
A
V
P
A
S
Y
T
G
K
F
L
A
E
V
V
-------------------
23
PsiBlast_CBE
67.96
59%
-2
- C2 -
3ZQJ
3
UVRA_MYCTU
B:
[24-974]
---
D
R
L
I
V
K
G
A
R
E
H
N
L
R
S
V
D
L
D
L
P
R
D
A
L
I
V
F
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
F
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
D
K
P
D
V
D
F
I
E
G
---
L
S
P
A
V
S
I
D
Q
K
S
T
N
R
N
P
R
S
T
V
G
T
I
T
E
V
Y
D
Y
L
R
L
L
Y
A
R
A
G
T
P
H
C
P
T
C
G
E
R
V
A
R
Q
T
P
Q
Q
I
V
D
Q
V
L
A
M
P
E
G
T
R
F
L
V
L
A
P
V
V
R
T
R
K
G
E
F
A
D
L
F
D
K
L
N
A
Q
G
Y
S
R
V
R
V
D
G
V
V
H
P
L
T
D
P
P
K
L
K
K
Q
E
K
H
D
I
E
V
V
V
D
--------
K
R
R
L
T
D
S
V
E
T
A
L
N
L
A
D
G
I
V
V
L
------------
F
S
E
K
L
A
C
P
N
G
H
A
L
A
V
D
D
L
E
P
R
S
F
S
F
N
S
P
Y
G
A
C
P
E
C
S
G
L
G
I
R
K
E
V
D
P
E
L
V
V
P
-----------
A
P
W
S
N
G
H
T
A
-
E
Y
F
T
R
M
M
A
G
L
G
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A
L
G
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D
V
D
T
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W
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K
L
P
A
K
A
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K
A
I
L
E
G
A
-
D
E
Q
V
-----
H
V
R
Y
R
-------
N
R
Y
G
R
T
R
S
Y
Y
A
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F
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G
V
L
----
A
F
L
Q
R
----
K
M
S
Q
T
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S
E
Q
M
K
E
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Y
E
G
F
M
R
D
V
P
C
P
V
C
A
G
T
R
L
K
P
E
I
L
A
V
T
L
A
G
ESKGEHGA
K
S
I
A
E
V
C
E
L
S
I
A
D
C
A
D
F
L
N
A
L
T
----------
L
G
P
---
R
---------
E
Q
A
I
A
G
Q
--
V
L
K
E
I
R
S
R
L
G
F
L
L
D
V
G
L
E
Y
L
S
L
S
R
A
A
A
T
L
S
G
G
E
A
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R
I
R
L
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Q
I
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G
V
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V
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D
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Y
L
S
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R
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S
I
E
I
P
A
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R
-
R
S
V
D
P
R
R
Q
L
T
V
V
G
A
R
E
H
N
L
R
G
I
D
V
S
F
P
L
G
V
L
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
N
D
I
L
A
A
V
L
A
N
R
L
N
G
------------
A
R
Q
----------
V
P
G
R
H
T
R
V
T
G
-
L
D
Y
L
D
K
L
V
R
V
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
K
I
R
T
L
F
A
A
T
T
E
A
K
----------------------------------------------------------------------------------------------------------------------------------------
V
R
G
Y
Q
P
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
T
G
D
G
T
I
K
I
-
E
M
N
--------------------------------------------------------------------------------------------------------
F
L
P
--
D
V
Y
V
P
C
E
V
C
Q
G
A
R
Y
N
R
E
T
L
E
V
H
Y
K
G
--------
K
T
V
S
E
V
L
D
M
S
I
E
E
A
A
E
F
F
E
P
I
A
--------------
G
V
H
R
Y
L
R
T
L
V
D
V
G
L
G
Y
V
R
L
G
Q
P
A
P
T
L
S
G
G
E
A
Q
R
V
K
L
A
S
E
L
Q
K
R
S
T
G
R
T
V
Y
I
L
D
E
P
T
T
G
L
H
F
D
D
I
R
K
L
L
N
V
I
N
G
L
V
D
-
K
G
N
T
V
I
V
I
E
H
N
L
D
V
I
K
-
T
S
D
W
I
I
D
L
G
P
E
G
G
A
G
G
G
T
V
V
A
Q
G
T
P
E
D
V
A
A
V
P
A
S
Y
T
G
K
F
L
A
E
V
V
-------------------
21
PsiBlast_CBE
65.97
59%
12
- C2 -
3ZQJ
2
UVRA_MYCTU
E:
[24-974]
---
D
R
L
I
V
K
G
A
R
E
H
N
L
R
S
V
D
L
D
L
P
R
D
A
L
I
V
F
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
F
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
D
K
P
D
V
D
F
I
E
G
---
L
S
P
A
V
S
I
D
Q
K
S
T
N
R
N
P
R
S
T
V
G
T
I
T
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V
Y
D
Y
L
R
L
L
Y
A
R
A
G
T
P
H
C
P
------
A
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Q
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P
Q
Q
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L
A
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T
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V
R
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D
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P
L
T
D
P
P
K
L
K
K
Q
E
K
H
D
I
E
V
V
V
D
--------
K
R
R
L
T
D
S
V
E
T
A
L
N
L
A
D
G
I
V
V
L
E
F
V
D
H
-----------
L
A
C
P
N
G
H
A
L
A
V
D
D
L
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R
S
F
S
F
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Y
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A
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P
E
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--
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A
-
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-----
H
V
R
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R
-------
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L
----
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----
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M
S
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K
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F
M
R
D
V
P
C
P
V
C
A
G
T
R
L
K
P
E
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L
A
V
T
L
A
-KGEHGA--
K
S
I
A
E
V
C
E
L
S
I
A
D
C
A
D
F
L
N
A
L
T
----------
L
G
P
---
R
---------
E
Q
A
I
A
G
Q
--
V
L
K
E
I
R
S
R
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F
L
L
D
V
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E
Y
L
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L
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R
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E
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R
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R
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P
R
R
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L
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V
G
A
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N
L
R
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I
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F
P
L
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V
L
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
N
D
I
L
A
A
V
L
A
N
R
L
N
G
------------
A
R
Q
----------
V
P
G
R
H
T
R
V
T
G
-
L
D
Y
L
D
K
L
V
R
V
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
K
I
R
T
L
F
A
A
T
T
E
A
K
----------------------------------------------------------------------------------------------------------------------------------------
V
R
G
Y
Q
P
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
T
G
D
G
T
I
K
I
-
E
M
N
--------------------------------------------------------------------------------------------------------
F
L
P
--
D
V
Y
V
P
C
E
V
C
Q
G
A
R
Y
N
R
E
T
L
E
V
H
Y
K
G
--------
K
T
V
S
E
V
L
D
M
S
I
E
E
A
A
E
F
F
E
P
I
A
--------------
G
V
H
R
Y
L
R
T
L
V
D
V
G
L
G
Y
V
R
L
G
Q
P
A
P
T
L
S
G
G
E
A
Q
R
V
K
L
A
S
E
L
Q
K
R
S
T
G
R
T
V
Y
I
L
D
E
P
T
T
G
L
H
F
D
D
I
R
K
L
L
N
V
I
N
G
L
V
D
-
K
G
N
T
V
I
V
I
E
H
N
L
D
V
I
K
-
T
S
D
W
I
I
D
L
G
P
E
G
G
A
G
G
G
T
V
V
A
Q
G
T
P
E
D
V
A
A
V
P
A
S
Y
T
G
K
F
L
A
E
V
V
-------------------
22
PsiBlast_CBE
64.65
59%
24
- C2 -
3ZQJ
3
UVRA_MYCTU
C:
[24-974]
---
D
R
L
I
V
K
G
A
R
E
H
N
L
R
S
V
D
L
D
L
P
R
D
A
L
I
V
F
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
F
A
E
G
Q
R
R
Y
V
E
S
L
S
A
Y
A
R
Q
F
L
G
Q
M
D
K
P
D
V
D
F
I
E
G
---
L
S
P
A
V
S
I
D
Q
K
S
T
N
R
N
P
R
S
T
V
G
T
I
T
E
V
Y
D
Y
L
R
L
L
Y
A
R
A
G
T
P
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C
P
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C
G
E
R
V
A
R
Q
T
P
Q
Q
I
V
D
Q
V
L
A
M
P
------
V
L
A
P
V
V
R
T
R
K
G
E
F
A
D
L
F
D
K
L
N
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Q
G
Y
S
R
V
R
V
D
G
V
V
H
P
L
T
D
P
P
K
L
K
K
Q
E
K
H
D
I
E
V
V
----------
K
R
R
L
T
D
S
V
E
T
A
L
N
L
A
D
G
I
V
V
-----------------
L
A
C
P
N
G
H
A
L
A
V
D
D
L
E
P
R
S
F
S
F
N
S
P
Y
G
A
C
P
E
C
S
G
L
G
I
R
K
E
V
D
P
E
L
V
V
P
---------
A
V
A
P
W
S
N
G
H
T
A
-
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Y
F
T
R
M
M
A
G
L
G
E
A
L
G
------------
K
A
R
K
A
I
L
E
G
A
-
D
E
Q
V
-----
H
V
R
Y
R
-------
N
R
Y
G
R
T
R
S
Y
Y
A
D
F
E
G
V
L
----
A
F
L
Q
R
----
K
M
S
Q
T
E
S
E
Q
M
K
E
R
Y
E
G
F
M
R
D
V
P
C
P
V
C
A
G
T
R
L
K
P
E
I
L
A
V
T
L
A
G
HGA-----
K
S
I
A
E
V
C
E
L
S
I
A
D
C
A
D
F
L
N
A
L
T
----------
L
G
P
---
R
---------
E
Q
A
I
A
G
Q
--
V
L
K
E
I
R
S
R
L
G
F
L
L
D
V
G
L
E
Y
L
S
L
S
R
A
A
A
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
G
L
V
-
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
R
R
L
I
E
T
L
T
R
L
R
D
L
G
N
T
L
I
V
V
E
H
D
E
D
T
I
E
H
A
D
W
I
V
D
I
G
P
G
A
G
E
H
G
G
R
I
V
H
S
G
P
Y
D
E
L
L
R
N
K
D
S
I
T
G
A
Y
L
S
G
R
E
S
I
E
I
P
A
I
R
-
R
S
V
D
P
R
R
Q
L
T
V
V
G
A
R
E
H
N
L
R
G
I
D
V
S
F
P
L
G
V
L
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
N
D
I
L
A
A
V
L
A
N
R
L
N
G
------------
A
R
Q
----------
V
P
G
R
H
T
R
V
T
G
-
L
D
Y
L
D
K
L
V
R
V
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
K
I
R
T
L
F
A
A
T
T
E
A
K
----------------------------------------------------------------------------------------------------------------------------------------
V
R
G
Y
Q
P
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
T
G
D
G
T
I
K
I
-
E
M
N
--------------------------------------------------------------------------------------------------------
F
L
P
--
D
V
Y
V
P
C
E
V
C
Q
G
A
R
Y
N
R
E
T
L
E
V
H
Y
K
G
--------
K
T
V
S
E
V
L
D
M
S
I
E
E
A
A
E
F
F
E
P
I
A
--------------
G
V
H
R
Y
L
R
T
L
V
D
V
G
L
G
Y
V
R
L
G
Q
P
A
P
T
L
S
G
G
E
A
Q
R
V
K
L
A
S
E
L
Q
K
R
S
T
G
R
T
V
Y
I
L
D
E
P
T
T
G
L
H
F
D
D
I
R
K
L
L
N
V
I
N
G
L
V
D
-
K
G
N
T
V
I
V
I
E
H
N
L
D
V
I
K
-
T
S
D
W
I
I
D
L
G
P
E
G
G
A
G
G
G
T
V
V
A
Q
G
T
P
E
D
V
A
A
V
P
A
S
Y
T
G
K
F
L
A
E
V
V
-------------------
109
HHSearch
58.27
46%
10
- C2 -
2VF7
4
?
A:
[12-841]
-
D
G
G
F
V
Q
V
R
G
A
R
Q
H
N
L
K
D
I
S
V
K
V
P
R
D
A
L
V
V
F
T
G
V
S
G
S
G
K
S
S
L
A
F
G
T
L
Y
A
E
A
Q
R
R
Y
L
E
S
V
S
P
Y
A
R
R
L
F
N
Q
A
G
V
P
D
V
D
A
I
D
G
---
L
P
P
A
V
A
L
Q
Q
A
R
G
T
P
T
A
R
S
S
V
G
S
V
T
T
L
S
N
L
L
R
M
L
Y
S
R
A
G
D
Y
P
P
-
G
Q
G
I
------------------------------------------------------------------------------------------------------------------------------------------
V
Y
A
E
G
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
P
S
L
T
I
R
E
R
A
V
A
A
W
P
Q
-
A
W
----
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
T
D
E
Q
P
V
V
-----
P
V
Y
P
G
LT
P
A
E
T
Q
R
A
L
K
--
K
K
M
E
P
S
Y
M
G
T
F
----
S
S
A
R
R
H
V
L
H
T
F
A
N
T
E
S
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
--------
L
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
L
L
R
P
Y
A
----------
E
E
R
EPG
H
AERVKNRPE
Q
A
I
A
L
Q
R
--
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
-
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
G
Q
Y
L
F
A
D
R
H
T
--
E
P
H
T
-
P
R
E
P
A
G
-
W
L
E
L
N
G
V
T
R
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
G
Q
---------------------------
G
S
A
-
R
L
G
G
D
L
A
Q
I
T
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
----------------------------------------------------------------------------------------------------------------------------------------
K
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
-
E
L
L
--------------------------------------------------------------------------------------------------------
F
L
P
--
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
--------
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
E
S
--------------
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
-
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
-------------------
24
PsiBlast_CBE
50.98
43%
-0
- C2 -
2VF8
9
?
B:
[142-841]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
P
S
L
T
I
R
E
R
A
V
A
A
W
----
P
Q
-
A
W
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
T
D
E
Q
P
V
V
P
V
Y
P
G
L
T
P
A
E
-------
T
Q
R
A
L
K
K
K
M
E
P
S
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
----
T
F
A
N
T
E
S
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
--------
L
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
L
L
R
P
Y
A
EEREPG
H
A
E
R
V
K
N
---
R
---------
P
E
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
-
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
G
Q
Y
L
F
A
D
R
H
T
E
-
P
H
T
P
-
R
E
P
A
G
--
W
L
E
L
N
G
V
T
R
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
G
Q
PVNPDP
E
D
D
E
DP
A
D
H
----------
T
A
G
S
A
R
L
G
G
D
-
L
A
Q
I
T
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
----------------------------------------------------------------------------------------------------------------------------------------
K
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
-
E
L
L
--------------------------------------------------------------------------------------------------------
F
L
P
--
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
--------
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
E
S
--------------
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
-
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
-------------------
4
PsiBlast_PDB
50.19
43%
4
- C2 -
2VF7
4
?
A:
[142-841]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
P
S
L
T
I
R
E
R
A
V
A
A
W
----
P
Q
-
A
W
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
T
D
E
Q
P
V
V
P
V
Y
P
G
L
T
P
A
E
-------
T
Q
R
A
L
K
K
K
M
E
P
S
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
----
T
F
A
N
T
E
S
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
--------
L
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
L
L
R
P
Y
A
EEREPGHAER
V
K
N
---
R
---------
P
E
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
-
G
V
V
Y
V
L
D
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P
S
A
G
L
H
P
A
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T
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A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
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H
D
L
D
V
I
R
R
A
D
W
L
V
D
V
G
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A
G
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K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
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Q
Y
L
F
A
D
R
H
T
E
-
P
H
T
P
-
R
E
P
A
G
--
W
L
E
L
N
G
V
T
R
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
G
Q
---------------------------
G
S
A
R
L
G
G
D
-
L
A
Q
I
T
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
----------------------------------------------------------------------------------------------------------------------------------------
K
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
-
E
L
L
--------------------------------------------------------------------------------------------------------
F
L
P
--
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
--------
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
E
S
--------------
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
-
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
-------------------
26
PsiBlast_CBE
49.94
43%
9
- C2 -
2VF7
4
?
B:
[142-841]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
P
S
L
T
I
R
E
R
A
V
A
A
W
----
P
Q
-
A
W
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
T
D
E
Q
P
V
V
P
V
Y
P
G
L
T
P
A
E
-------
T
Q
R
A
L
K
K
K
M
E
P
S
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
----
T
F
A
N
T
E
S
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
--------
L
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
L
L
R
P
Y
A
EEREPG
H
A
E
R
V
K
N
---
R
---------
P
E
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
-
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
G
Q
Y
L
F
A
D
R
H
T
E
-
P
H
T
P
-
R
E
P
A
G
--
W
L
E
L
N
G
V
T
R
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
G
Q
---------------------------
G
S
A
R
L
G
G
D
-
L
A
Q
I
T
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
----------------------------------------------------------------------------------------------------------------------------------------
K
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
--------------------------------------------------------------------------------------------------------------
P
--
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
--------
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
E
S
--------------
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
-
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
-------------------
25
PsiBlast_CBE
49.39
43%
5
- C2 -
2VF7
5
?
C:
[142-841]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
P
S
L
T
I
R
E
R
A
V
A
A
W
----
P
Q
-
A
W
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
T
D
E
Q
P
V
V
P
V
Y
P
G
L
T
P
A
E
-------
T
Q
R
A
L
K
K
K
M
E
P
S
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
----
T
F
A
N
T
E
S
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
--------
L
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
L
L
R
P
Y
A
EEREPGHA
E
R
V
K
N
---
R
---------
P
E
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
-
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
G
Q
Y
L
F
A
D
R
H
T
E
-
P
H
T
P
-
R
E
P
A
G
--
W
L
E
L
N
G
V
T
R
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
G
-----------------------------
S
A
R
L
G
G
D
-
L
A
Q
I
T
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
----------------------------------------------------------------------------------------------------------------------------------------
K
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
-
E
L
L
--------------------------------------------------------------------------------------------------------
F
L
P
--
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
--------
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
E
S
--------------
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
-
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
-------------------
5
PsiBlast_PDB
48.99
43%
13
- C2 -
2VF8
7
?
A:
[142-841]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
P
N
T
P
E
G
A
C
P
E
C
H
G
L
G
R
V
Y
T
V
T
E
D
S
M
V
P
D
P
S
L
T
I
R
E
R
A
V
A
A
W
----
P
Q
-
A
W
G
G
Q
N
Q
R
D
I
L
V
T
L
G
I
D
V
D
V
P
W
R
E
L
P
E
E
T
R
H
W
I
L
F
T
D
E
Q
P
V
V
P
V
YPG
L
T
P
A
E
-------
T
Q
R
A
L
K
K
K
M
E
P
S
Y
M
G
T
F
S
S
A
R
R
H
V
L
H
----
T
F
A
N
T
E
S
A
S
M
K
K
R
V
Q
G
Y
M
I
S
E
E
C
P
L
C
H
G
K
R
L
R
Q
E
A
L
N
V
T
F
A
G
--------
L
D
I
T
E
L
S
R
L
P
L
A
R
V
S
E
L
L
R
P
Y
A
EEREPGHAER
V
K
N
---
R
---------
P
E
Q
A
I
A
L
Q
R
M
A
A
D
L
V
K
R
L
D
V
L
L
H
L
G
L
G
Y
L
G
L
D
R
S
T
P
T
L
S
P
G
E
L
Q
R
L
R
L
A
T
Q
L
Y
S
N
L
F
-
G
V
V
Y
V
L
D
E
P
S
A
G
L
H
P
A
D
T
E
A
L
L
S
A
L
E
N
L
K
R
G
G
N
S
L
F
V
V
E
H
D
L
D
V
I
R
R
A
D
W
L
V
D
V
G
P
E
A
G
E
K
G
G
E
I
L
Y
S
G
P
P
E
G
L
K
H
V
P
E
S
Q
T
G
Q
Y
L
F
A
D
---
E
-
P
H
T
P
-
R
E
P
A
G
--
W
L
E
L
N
G
V
T
R
N
N
L
D
N
L
D
V
R
F
P
L
G
V
M
T
S
V
T
G
V
S
G
S
G
K
S
T
L
V
S
Q
A
L
V
D
A
L
A
A
H
F
G
Q
---------------------------
G
S
A
R
L
G
G
D
-
L
A
Q
I
T
R
L
V
R
V
D
Q
K
P
I
G
R
T
P
R
S
N
M
A
T
Y
T
G
L
F
D
Q
V
R
K
L
F
A
A
T
P
L
A
K
----------------------------------------------------------------------------------------------------------------------------------------
K
R
G
Y
N
A
G
R
F
S
F
N
V
K
G
G
R
C
E
H
C
Q
G
E
G
W
V
M
V
--------------------------------------------------------------------------------------------------------------
P
--
S
V
Y
A
P
C
P
V
C
H
G
T
R
Y
N
A
E
T
L
E
V
E
Y
R
G
--------
K
N
I
A
D
V
L
A
L
T
V
D
E
A
H
D
F
F
A
D
E
S
--------------
A
I
F
R
A
L
D
T
L
R
E
V
G
L
G
Y
L
R
L
G
Q
P
A
T
E
L
S
G
G
E
A
Q
R
I
K
L
A
T
E
L
R
R
S
G
R
G
G
T
V
Y
V
L
D
E
P
T
T
G
L
H
P
A
D
V
E
R
L
Q
R
Q
L
V
K
L
V
D
-
A
G
N
T
V
I
A
V
E
H
K
M
Q
V
V
A
-
A
S
D
W
V
L
D
I
G
P
G
A
G
E
D
G
G
R
L
V
A
Q
G
T
P
A
E
V
A
Q
A
A
G
S
V
T
A
P
Y
L
R
A
A
L
-------------------
118
HHSearch
46.89
40%
-67
- C2 -
2R6F
3
?
A:
[628-953]
---
R
W
L
E
V
V
G
A
R
E
H
N
L
K
N
V
S
V
K
I
P
L
G
T
F
V
A
V
T
G
V
S
G
S
G
K
S
T
L
V
N
E
V
L
Y
K
A
L
A
Q
K
L
H
R
A
-------
K
A
K
P
G
E
H
R
D
I
R
G
L
E
H
---
L
D
K
V
I
D
I
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
G
V
F
D
D
I
R
D
V
F
A
S
T
N
E
A
K
---------------------------------------------------------------------------------------------------------------------------------------------
V
R
G
Y
K
K
G
R
F
S
F
N
V
K
G
G
R
C
E
A
C
H
G
D
G
I
I
K
I
E
M
-
H
--------------------------
F
------------------------------------------------------------------------------------------------------
L
P
D
V
Y
V
P
C
E
V
C
H
G
K
R
Y
N
R
E
T
L
E
V
T
Y
K
G
--------
K
N
I
A
E
V
L
D
M
T
V
E
D
A
L
D
F
F
A
S
I
P
--------------------------------------
K
I
K
R
K
L
E
T
L
Y
D
V
G
L
G
Y
M
K
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
V
K
L
A
A
E
L
H
R
R
S
N
G
R
T
L
Y
I
L
D
E
P
T
T
G
L
H
V
D
D
I
A
R
L
L
D
V
L
H
R
L
V
D
N
G
D
T
V
L
V
I
E
H
N
L
D
V
I
K
T
A
D
Y
I
I
D
L
G
P
E
G
G
D
R
G
G
Q
I
V
A
V
G
T
P
E
E
V
A
E
V
K
E
S
H
T
G
R
Y
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
HHSearch
43.60
39%
7
- C2 -
3ZQJ
2
UVRA_MYCTU
A:
[23-628]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
-
R
L
I
V
K
G
A
R
E
H
N
L
R
S
V
D
L
D
L
P
R
D
A
L
I
V
F
T
G
L
S
G
S
G
K
S
S
L
A
F
D
T
I
F
A
E
G
Q
R
R
Y
V
E
------------
S
L
S
A
Y
A
R
Q
F
L
GQM
D
K
P
D
V
D
F
I
E
G
----
L
S
P
A
V
S
I
D
Q
K
S
T
N
R
N
P
R
S
T
V
G
T
I
T
E
V
Y
D
Y
L
R
L
L
Y
A
R
A
G
T
P
H
C
PTCGER
V
A
R
Q
T
P
Q
Q
I
V
D
Q
V
L
A
MPEG
T
R
F
L
VLAPVVRT
R
K
G
E
F
A
D
L
F
D
K
L
N
AQGYS
R
V
R
V
DGVVHPLT
D
P
P
K
L
K
KQ
E
K
H
D
I
E
V
VVDRLTVKAAA
K
R
R
L
T
D
S
V
E
T
A
L
N
L
A
DG
I
V
V
L
E
F
VDE
Q
R
F
S
EKLACPNGHALA
V
D
D
L
E
P
R
S
F
S
F
N
S
P
Y
G
A
C
P
E
C
S
G
L
G
I
R
K
E
V
D
P
E
LVVPDPDRTLA
Q
G
A
VAPWSN
G
H
T
A
E
Y
F
T
R
M
M
A
GLGEALGFDVDTPWRKL
P
A
K
A
R
K
A
I
LEGAD
E
Q
V
H
V
R
Y
R
N
RYGRTR
S
Y
Y
A
DFEGVLAF
L
Q
R
K
M
S
Q
T
ESE
Q
M
K
E
R
Y
E
GF
M
R
D
V
P
C
P
V
C
A
G
T
R
L
K
P
E
I
L
A
V
T
L
A
G
E
SKGEH
G
A
K
S
I
A
E
V
C
E
L
S
I
A
D
C
A
D
F
L
N
A
L
T
LG
P
R
E
Q
A
I
A
G
Q
V
L
K
E
I
R
S
R
L
G
F
L
L
D
V
G
L
E
Y
L
S
L
S
R
A
A
A
T
L
S
G
G
E
A
Q
R
I
R
L
A
T
Q
I
G
S
G
-
L
V
G
V
L
Y
V
L
D
E
P
S
I
G
L
H
Q
R
D
N
R
R
L
I
E
T
L
T
R
L
R
D
-
L
G
N
T
L
I
V
V
E
H
D
E
D
T
I
E
-
H
A
D
W
I
V
D
I
G
P
G
A
G
E
H
G
G
R
I
V
H
S
G
P
Y
D
E
L
L
R
N
K
D
S
I
T
G
A
Y
L
S
----------------------
18
PsiBlast_PDB
43.49
37%
-135
- C3 -
1YQT
1
?
A:
[159-227]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
A
T
---
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
N
A
A
R
A
I
R
R
L
S
E
-
E
G
K
S
V
L
V
V
E
H
D
L
A
V
L
----
D
Y
L
S
D
I
-------------------------------------------------------
11
PsiBlast_PDB
43.48
37%
-153
- C3 -
3J15
-
?
B:
[215-283]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
H
---
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
K
V
A
R
V
I
R
R
L
A
N
-
E
G
K
A
V
L
V
V
E
H
D
L
A
V
L
----
D
Y
L
S
D
V
-------------------------------------------------------
98
Fugue
41.40
49%
-130
* C4 *
4DFC
-
UVRA_ECOLI
B:
[128-250]
------------------------------------------------------------------------------------------------------------------------------------
M
A
S
T
V
S
Q
M
V
D
N
V
L
S
Q
P
E
G
K
R
L
M
L
L
A
P
I
I
K
E
R
K
G
E
H
T
K
T
L
E
N
L
A
S
Q
G
Y
I
R
A
R
I
D
G
E
V
C
D
L
S
D
P
P
K
L
E
L
Q
K
K
H
T
I
E
V
V
V
D
R
F
K
V
R
L
T
--
Q
R
L
A
E
S
F
E
T
A
L
E
L
S
G
G
T
A
V
V
A
D
M
D
D
PK
A
E
E
L
L
F
S
A
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
41.25
37%
-142
- C3 -
3BK7
-
?
A:
[229-297]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
H
---
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
K
V
A
R
V
I
R
R
L
A
N
-
E
G
K
A
V
L
V
V
E
H
D
L
A
V
L
----
D
Y
L
S
D
V
-------------------------------------------------------
114
HHSearch
37.64
41%
-32
- C2 -
3PIH
3
UVRA_THEMA
A:
[588-904]
---
A
S
L
K
I
K
G
V
R
H
N
N
L
K
N
I
D
V
E
I
P
L
G
V
F
V
C
V
T
G
V
S
G
S
G
K
S
S
L
V
M
E
T
L
Y
P
A
L
M
N
L
L
H
K
----
T
------
K
L
P
A
G
E
F
D
S
I
E
G
HEN
I
D
K
M
I
A
I
D
Q
S
P
I
G
R
T
P
R
S
N
P
A
T
Y
T
K
V
F
D
E
I
R
S
L
F
A
M
T
P
A
--
A
K
-------------------------------------------------------------------------------------------------------------------------------------------
A
R
G
Y
N
K
S
R
F
S
F
N
L
K
G
G
R
C
E
A
C
Q
G
Q
G
Y
V
K
I
E
M
-
L
--------------------------
F
------------------------------------------------------------------------------------------------------
L
P
D
V
Y
V
E
C
D
V
C
K
G
K
R
Y
N
R
E
T
L
E
I
T
Y
K
G
--------
K
N
I
S
D
I
L
D
M
T
V
D
E
A
L
E
F
F
K
N
I
P
----------
S
----------------------------
I
K
R
T
L
Q
V
L
H
D
V
G
L
G
Y
V
K
L
G
Q
P
A
T
T
L
S
G
G
E
A
Q
R
I
K
L
A
S
E
L
R
K
R
D
T
G
R
T
L
Y
I
L
D
E
P
T
V
G
L
H
F
E
D
V
R
K
L
V
E
V
L
H
R
L
V
D
R
G
N
T
V
I
V
I
E
H
N
L
D
V
I
K
N
A
D
H
I
I
D
L
G
P
E
G
G
K
E
G
G
Y
I
V
A
T
G
T
P
E
E
I
A
K
N
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
HHSearch
35.64
31%
-91
* C2 *
4YER
3
?
A:
[118-255]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
L
L
E
F
V
E
L
L
E
F
-
K
D
K
P
V
K
T
F
S
G
G
M
A
R
R
L
E
I
A
R
S
L
I
H
E
---
P
E
V
L
F
L
D
E
P
T
I
G
L
D
P
H
T
R
A
H
M
W
E
Y
I
S
K
M
K
K
E
H
N
M
T
I
F
L
T
T
H
Y
M
D
E
A
E
Q
L
A
D
R
V
A
I
I
------
D
H
G
K
I
I
A
L
G
T
P
T
E
L
K
R
M
--------------------------------