@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu35580: (2016-07-30 )
MKKIAVIGTGYVGLVSGTCFAEIGNKVVCCDIDESKIRSLKNGVIPIYEPGLADLVEKNVLDQRLTFTNDIPSAIRASDIIYIAVGTPMSKTGEADLTYVKAAAKTIGEHLNGYKVIVNKSTVPVGTGKLVQSIVQKASKGRYSFDVVSNPEFLREGSAIHDTMNMERAVIGSTSHKAAAIIEELHQPFHAPVIKTNLESAEMIKYAANAFLATKISFINDIANICERVGADVSKVADGVGLDSRIGRKFLKAGIGFGGSCFPKDTTALLQIAKSAGYPFKLIEAVIETNEKQRVHIVDKLLTVMGSVKGRTISVLGLAFKPNTNDVRSAPALDIIPMLQQLGAHVKAYDPIAIPEASAILGEQVEYYTDVYAAMEDTDACLILTDWPEVKEMELVKVKTLLKQPVIIDGRNLFSLEEMQAAGYIYHSIGRPAVRGTEPSDKYFPGLPLEELAKDLGSVNL
Atome Classification :
(22 SA)
.........10........20....--....30........40........50........60........70........80.......-----.90.-........100.......110---.......120.......130.....---..140-..---.......150.......160.......170...----.----...180.......---190--.---.......200.......210.......220.......230.......240.......250.......260.......270.......--280.......290.......300-.-..-.-...310.......320.......330.......340.......350.......360----------.---------.----------.......----370.......380.......390......-.400.......410...--....420.......430.......440.......450.......460
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
K
I
A
V
I
GTG
Y
V
G
LVS
G
T
C
F
A
E
IG
N
--
K
V
V
C
CDI
D
E
S
K
I
R
S
L
KNG
V
I
P
IYEP
G
L
A
D
L
V
E
K
N
V
L
D
Q
RLTFTNDI
P
S
AIRAS
D
I
I
Y
I
AVGTP-----MS-K-TGEA
D
L
T
Y
V
K
A
A
A
K
T
I
G
E
HLN---G
Y
K
V
I
V
NKSTVPVG
T
G
K
L
V
Q
S
I
V
Q
K
---ASK---GR---
Y
S
F
D
VVS
N
P
E
F
L
REGSAIH
D
T
M
N
M
E
R
A
VIGSTS----
H
----
K
A
A
A
I
I
E
E
L
HQPF---HA---P---
V
I
KTNL
E
S
A
E
M
I
K
Y
A
A
N
A
F
L
A
T
K
I
S
F
I
N
D
I
A
N
I
C
E
R
VGA
D
V
S
K
V
A
DGVG
L
D
S
R
I
G
R
K
F
L
K
A
GIGFGGSCFPK
D
T
T
A
L
L
Q
I
A
K
SAGY
P
--
F
K
L
I
E
A
V
I
ETNEK
Q
R
V
H
I
V
D
K
L
L
-
T
-
V
M
-G-SVKG
R
T
I
S
V
L
G
L
A
FKPNTNDVRSAP
A
L
D
I
I
P
M
L
Q
Q
LG
A
H
VKAYDPIAIP
E
A
S
A
I
------------
L
---------
G
----------
E
Q
V
E
Y
Y
T
----
D
V
Y
A
AMEDT
D
A
C
L
I
LTDWPEV
K
E
M
E
L
V
K
V
-
K
T
L
LKQ
P
V
I
IDGRNLF
S
--
L
E
E
M
Q
A
A
G
Y
I
Y
HSIGRPAVRGTEPSDKYFPGL
P
L
E
E
L
A
K
D
LGSVNL
2
PsiBlast_PDB
97.00
48%
0
- C- -
3GG2
4
?
A:
[5-428]
---
I
A
V
V
G
I
G
Y
V
G
L
V
S
A
T
C
F
A
E
L
G
A
--
N
V
R
C
I
D
T
D
R
N
K
I
E
Q
L
N
S
G
T
I
P
I
Y
E
P
G
L
E
K
M
I
A
R
N
V
K
A
G
R
L
R
F
G
T
E
I
E
Q
A
V
P
E
A
D
I
I
F
I
A
V
G
T
P
-----
A
G
-
E
-
D
G
S
A
D
M
S
Y
V
L
D
A
A
R
S
I
G
R
A
M
S
---
R
Y
I
L
I
V
T
K
S
T
V
P
V
G
S
Y
R
L
I
R
K
A
I
Q
E
---
E
L
D
---
K
R
E
V
L
I
D
F
D
I
A
S
N
P
E
F
L
K
E
G
N
A
I
D
D
F
M
K
P
D
R
V
V
V
G
V
D
S
----
D
----
R
A
R
E
L
I
T
S
L
Y
K
P
M
LLN
N
F
---
R
---
V
L
F
M
D
I
A
S
A
E
M
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
D
V
A
N
L
C
E
R
V
G
A
D
V
S
M
V
R
L
G
I
G
S
D
S
R
I
G
S
K
F
L
Y
P
G
C
G
Y
G
G
S
C
F
P
K
D
V
K
A
L
I
R
T
A
E
D
N
G
Y
R
--
M
E
V
L
E
A
V
E
R
V
N
E
K
Q
K
S
I
L
F
D
K
F
S
-
T
-
Y
Y
K
G
-
N
V
Q
G
R
C
V
A
I
W
G
L
S
F
K
P
G
T
D
D
M
R
E
A
P
S
L
V
L
I
E
K
L
L
E
V
G
C
R
V
R
V
Y
D
P
V
A
M
K
E
A
Q
K
R
------------
L
---------
G
----------
D
K
V
E
Y
T
T
----
D
M
Y
D
A
V
R
G
A
E
A
L
F
H
V
T
E
W
K
E
F
R
M
P
D
W
S
A
L
-
S
Q
A
M
A
A
S
L
V
I
D
G
R
N
V
Y
E
--
L
---------------------------------------------
21
PsiBlast_CBE
96.03
48%
0
- C- -
3GG2
4
?
D:
[5-427]
---
I
A
V
V
G
I
G
Y
V
G
L
V
S
A
T
C
F
A
E
L
G
A
--
N
V
R
C
I
D
T
D
R
N
K
I
E
Q
L
N
S
G
T
I
P
I
Y
E
P
G
L
E
K
M
I
A
R
N
V
K
A
G
R
L
R
F
G
T
E
I
E
Q
A
V
P
E
A
D
I
I
F
I
A
V
G
T
P
-----------
G
S
A
D
M
S
Y
V
L
D
A
A
R
S
I
G
R
A
M
S
---
R
Y
I
L
I
V
T
K
S
T
V
P
V
G
S
Y
R
L
I
R
K
A
I
Q
E
---
E
L
D
---
K
R
E
V
L
I
D
F
D
I
A
S
N
P
E
F
L
K
E
G
N
A
I
D
D
F
M
K
P
D
R
V
V
V
G
V
D
S
----
D
----
R
A
R
E
L
I
T
S
L
Y
K
P
M
LLN
N
F
---
R
---
V
L
F
M
D
I
A
S
A
E
M
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
D
V
A
N
L
C
E
R
V
G
A
D
V
S
M
V
R
L
G
I
G
S
D
S
R
I
G
S
K
F
L
Y
P
G
C
G
Y
G
G
S
C
F
P
K
D
V
K
A
L
I
R
T
A
E
D
N
G
Y
R
--
M
E
V
L
E
A
V
E
R
V
N
E
K
Q
K
S
I
L
F
D
K
F
S
-
T
-
Y
Y
K
G
-
N
V
Q
G
R
C
V
A
I
W
G
L
S
F
K
P
G
T
D
D
M
R
E
A
P
S
L
V
L
I
E
K
L
L
E
V
G
C
R
V
R
V
Y
D
P
V
A
M
K
E
A
Q
K
R
------------
L
---------
G
----------
D
K
V
E
Y
T
T
----
D
M
Y
D
A
V
R
G
A
E
A
L
F
H
V
T
E
W
K
E
F
R
M
P
D
W
S
A
L
-
S
Q
A
M
A
A
S
L
V
I
D
G
R
N
V
Y
E
--
L
---------------------------------------------
25
PsiBlast_CBE
83.09
44%
-36
- C3 -
2Y0C
9
?
D:
[10-463]
--
N
L
T
I
I
G
S
G
S
V
G
L
V
T
G
A
C
L
A
D
I
G
H
--
D
V
F
C
L
D
V
D
Q
A
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
R
N
R
S
A
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
-----
P
--------
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
F
K
V
I
V
D
K
S
T
V
P
V
G
T
A
E
R
V
R
A
A
V
A
E
E
L
A
K
R
G
---
G
D
---
Q
M
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
D
D
D
V
P
G
E
----
R
A
R
E
L
M
K
K
L
Y
A
P
F
NRN
H
E
---
R
---
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
H
F
L
Y
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
Q
S
--
L
Q
I
L
K
A
V
S
S
V
N
A
T
Q
K
R
V
L
A
D
K
I
V
-
A
-
R
F
-
G
E
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
V
A
Q
E
E
A
R
R
V
------------
I
---------
A
L
D
L
A
DH
P
S
W
L
E
R
L
S
F
V
D
----
D
E
A
Q
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
-
G
R
L
W
K
T
P
V
I
F
D
G
R
N
L
Y
E
--
P
E
T
M
S
E
Q
G
I
E
Y
H
P
I
G
R
P
G
S
R
--------------------------
5
PsiBlast_PDB
82.93
44%
-33
- C3 -
2Y0D
7
?
A:
[11-463]
---
L
T
I
I
G
S
G
K
V
G
L
V
T
G
A
C
L
A
D
I
G
H
--
D
V
F
C
L
D
V
D
Q
A
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
R
N
R
S
A
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
-----
P
D
-
E
---
S
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
F
K
V
I
V
D
K
S
T
V
P
V
G
T
A
E
R
V
R
A
A
V
A
E
E
L
A
K
R
G
---
G
D
---
Q
M
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
D
D
D
V
P
G
E
----
R
A
R
E
L
M
K
K
L
Y
A
P
F
NRN
H
E
---
R
---
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
H
F
L
Y
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
Q
S
--
L
Q
I
L
K
A
V
S
S
V
N
A
T
Q
K
R
V
L
A
D
K
I
V
-
A
-
R
F
-
G
E
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
V
A
Q
E
E
A
R
R
V
------------
I
---------
A
L
D
L
A
DH
P
S
W
L
E
R
L
S
F
V
D
----
D
E
A
Q
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
-
G
R
L
W
K
T
P
V
I
F
D
G
R
N
L
Y
E
--
P
E
T
M
S
E
Q
G
I
E
Y
H
P
I
G
R
P
G
S
R
--------------------------
3
PsiBlast_PDB
82.80
44%
-32
- C3 -
2Y0E
10
?
A:
[10-463]
--
N
L
T
I
I
G
S
G
Y
V
G
L
V
T
G
A
C
L
A
D
I
G
H
--
D
V
F
C
L
D
V
D
Q
A
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
R
N
R
S
A
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
-----
P
D
-
E
-
D
G
S
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
F
K
V
I
V
D
K
S
T
V
P
V
G
T
A
E
R
V
R
A
A
V
A
E
E
L
A
K
R
G
---
G
D
---
Q
M
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
D
D
D
V
P
G
E
----
R
A
R
E
L
M
K
K
L
Y
A
P
F
NRN
H
E
---
R
---
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
H
F
L
Y
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
Q
S
--
L
Q
I
L
K
A
V
S
S
V
N
A
T
Q
K
R
V
L
A
D
K
I
V
-
A
-
R
F
-
G
E
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
V
A
Q
E
E
A
R
R
V
------------
I
---------
A
L
D
L
A
DH
P
S
W
L
E
R
L
S
F
V
D
----
D
E
A
Q
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
-
G
R
L
W
K
T
P
V
I
F
D
G
R
N
L
Y
E
--
P
E
T
M
S
E
Q
G
I
E
Y
H
P
I
G
R
P
G
S
R
--------------------------
28
PsiBlast_CBE
82.78
44%
-35
- C3 -
2Y0D
4
?
D:
[11-463]
---
L
T
I
I
G
S
G
K
V
G
L
V
T
G
A
C
L
A
D
I
G
H
--
D
V
F
C
L
D
V
D
Q
A
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
R
N
R
S
A
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
-----
P
-----
G
S
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
F
K
V
I
V
D
K
S
T
V
P
V
G
T
A
E
R
V
R
A
A
V
A
E
ELA
K
R
G
---
G
D
---
Q
M
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
D
D
DVPG
E
----
R
A
R
E
L
M
K
K
L
Y
A
P
F
NRN
H
E
---
R
---
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
H
F
L
Y
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
Q
S
--
L
Q
I
L
K
A
V
S
S
V
N
A
T
Q
K
R
V
L
A
D
K
I
V
-
A
-
R
F
-
G
E
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
V
A
Q
E
E
A
R
R
V
------------
I
---------
A
LDLADHPSWL
E
R
L
S
F
V
D
----
D
E
A
Q
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
-
G
R
L
W
K
T
P
V
I
F
D
G
R
N
L
Y
E
--
P
E
T
M
S
E
Q
G
I
E
Y
H
P
I
G
R
P
G
S
R
--------------------------
22
PsiBlast_CBE
82.35
44%
-34
- C3 -
2Y0E
7
?
D:
[10-463]
--
N
L
T
I
I
G
S
G
Y
V
G
L
V
T
G
A
C
L
A
D
I
G
H
--
D
V
F
C
L
D
V
D
Q
A
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
R
N
R
S
A
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
-----
P
--------
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
F
K
V
I
V
D
K
S
T
V
P
V
G
T
A
E
R
V
R
A
A
V
A
E
E
L
A
K
R
G
---
G
D
---
Q
M
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
D
D
D
V
P
G
E
----
R
A
R
E
L
M
K
K
L
Y
A
P
F
NRN
H
E
---
R
---
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
H
F
L
Y
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
Q
S
--
L
Q
I
L
K
A
V
S
S
V
N
A
T
Q
K
R
V
L
A
D
K
I
V
-
A
-
R
F
-
G
E
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
V
A
Q
E
E
A
R
R
V
------------
I
---------
A
L
D
L
A
DH
P
S
W
L
E
R
L
S
F
V
D
----
D
E
A
Q
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
-
G
R
L
W
K
T
P
V
I
F
D
G
R
N
L
Y
E
--
P
E
T
M
S
E
Q
G
I
E
Y
H
P
I
G
R
P
G
S
R
--------------------------
30
PsiBlast_CBE
82.21
44%
-38
- C3 -
2Y0D
3
?
B:
[11-461]
---
L
T
I
I
G
S
G
K
V
G
L
V
T
G
A
C
L
A
D
I
G
H
--
D
V
F
C
L
D
V
D
Q
A
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
R
N
R
S
A
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
------------
S
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
F
K
V
I
V
D
K
S
T
V
P
V
G
T
A
E
R
V
R
A
A
V
A
E
E
L
A
K
R
G
---
G
----
Q
M
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
D
D
D
V
P
G
E
----
R
A
R
E
L
M
K
K
L
Y
A
P
F
NRN
H
E
---
R
---
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
H
F
L
Y
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
Q
S
--
L
Q
I
L
K
A
V
S
S
V
N
A
T
Q
K
R
V
L
A
D
K
I
V
-
A
-
R
F
-
G
E
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
V
A
Q
E
E
A
R
R
V
------------
I
---------
A
L
D
L
A
DH
P
S
W
L
E
R
L
S
F
V
D
----
D
E
A
Q
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
-
G
R
L
W
K
T
P
V
I
F
D
G
R
N
L
Y
E
--
P
E
T
M
S
E
Q
G
I
E
Y
H
P
I
G
R
P
G
----------------------------
4
PsiBlast_PDB
82.16
44%
-28
- C3 -
2Y0C
11
?
A:
[10-463]
--
N
L
T
I
I
G
S
G
S
V
G
L
V
T
G
A
C
L
A
D
I
G
H
--
D
V
F
C
L
D
V
D
Q
A
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
R
N
R
S
A
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
-----
P
D
-
E
-
D
G
S
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
F
K
V
I
V
D
K
S
T
V
P
V
G
T
A
E
R
V
R
A
A
V
A
E
E
L
A
K
R
G
---
G
D
---
Q
M
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
D
D
D
V
P
G
E
----
R
A
R
E
L
M
K
K
L
Y
A
P
F
NRN
H
E
---
R
---
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
H
F
L
Y
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
Q
S
--
L
Q
I
L
K
A
V
S
S
V
N
A
T
Q
K
R
V
L
A
D
K
I
V
-
A
-
R
F
-
G
E
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
V
A
Q
E
E
A
R
R
V
------------
I
---------
A
L
D
L
A
DH
P
S
W
L
E
R
L
S
F
V
D
----
D
E
A
Q
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
-
G
R
L
W
K
T
P
V
I
F
D
G
R
N
L
Y
E
--
P
E
T
M
S
E
Q
G
I
E
Y
H
P
I
G
R
P
G
S
R
--------------------------
23
PsiBlast_CBE
82.14
44%
-34
- C3 -
2Y0E
13
?
C:
[10-463]
--
N
L
T
I
I
G
S
G
Y
V
G
L
V
T
G
A
C
L
A
D
I
G
H
--
D
V
F
C
L
D
V
D
Q
A
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
R
N
R
S
A
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
-----
P
D
-
E
-
D
G
S
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
F
K
V
I
V
D
K
S
T
V
P
V
G
T
A
E
R
V
R
A
A
V
A
E
E
L
A
K
R
----------
M
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
D
D
D
V
P
G
E
----
R
A
R
E
L
M
K
K
L
Y
A
P
F
NRN
H
E
---
R
---
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
H
F
L
Y
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
Q
S
--
L
Q
I
L
K
A
V
S
S
V
N
A
T
Q
K
R
V
L
A
D
K
I
V
-
A
-
R
F
-
G
E
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
V
A
Q
E
E
A
R
R
V
------------
I
---------
A
L
D
L
A
DH
P
S
W
L
E
R
L
S
F
V
D
----
D
E
A
Q
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
-
G
R
L
W
K
T
P
V
I
F
D
G
R
N
L
Y
E
--
P
E
T
M
S
E
Q
G
I
E
Y
H
P
I
G
R
P
G
S
R
--------------------------
26
PsiBlast_CBE
81.95
44%
-36
- C3 -
2Y0C
11
?
C:
[10-463]
--
N
L
T
I
I
G
S
G
S
V
G
L
V
T
G
A
C
L
A
D
I
G
H
--
D
V
F
C
L
D
V
D
Q
A
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
R
N
R
S
A
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
-----
P
D
-
E
-
D
G
S
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
F
K
V
I
V
D
K
S
T
V
P
V
G
T
A
E
R
V
R
A
A
V
A
E
E
L
A
K
R
G
--------
Q
M
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
D
D
D
V
P
G
E
----
R
A
R
E
L
M
K
K
L
Y
A
P
F
NRN
H
E
---
R
---
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
H
F
L
Y
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
Q
S
--
L
Q
I
L
K
A
V
S
S
V
N
A
T
Q
K
R
V
L
A
D
K
I
V
-
A
-
R
F
-
G
E
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
V
A
Q
E
E
A
R
R
V
------------
I
---------
A
L
D
L
A
DH
P
S
W
L
E
R
L
S
F
V
D
----
D
E
A
Q
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
-
G
R
L
W
K
T
P
V
I
F
D
G
R
N
L
Y
E
--
P
E
T
M
S
E
Q
G
I
E
Y
H
P
I
G
R
P
G
S
R
--------------------------
24
PsiBlast_CBE
81.89
44%
-35
- C3 -
2Y0E
9
?
B:
[10-463]
--
N
L
T
I
I
G
S
G
Y
V
G
L
V
T
G
A
C
L
A
D
I
G
H
--
D
V
F
C
L
D
V
D
Q
A
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
R
N
R
S
A
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
-----
P
-------
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
F
K
V
I
V
D
K
S
T
V
P
V
G
T
A
E
R
V
R
A
A
V
A
E
E
L
A
K
R
---------
Q
M
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
D
D
D
V
P
G
E
----
R
A
R
E
L
M
K
K
L
Y
A
P
F
NRN
H
E
---
R
---
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
H
F
L
Y
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
Q
S
--
L
Q
I
L
K
A
V
S
S
V
N
A
T
Q
K
R
V
L
A
D
K
I
V
-
A
-
R
F
-
G
E
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
V
A
Q
E
E
A
R
R
V
------------
I
---------
A
L
D
L
A
DH
P
S
W
L
E
R
L
S
F
V
D
----
D
E
A
Q
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
-
G
R
L
W
K
T
P
V
I
F
D
G
R
N
L
Y
E
--
P
E
T
M
S
E
Q
G
I
E
Y
H
P
I
G
R
P
G
S
R
--------------------------
27
PsiBlast_CBE
81.86
44%
-35
- C3 -
2Y0C
11
?
B:
[10-463]
--
N
L
T
I
I
G
S
G
S
V
G
L
V
T
G
A
C
L
A
D
I
G
H
--
D
V
F
C
L
D
V
D
Q
A
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
R
N
R
S
A
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
--------------
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
F
K
V
I
V
D
K
S
T
V
P
V
G
T
A
E
R
V
R
A
A
V
A
E
E
L
A
K
R
---------
Q
M
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
D
D
D
V
P
G
E
----
R
A
R
E
L
M
K
K
L
Y
A
P
F
NRN
H
E
---
R
---
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
H
F
L
Y
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
Q
S
--
L
Q
I
L
K
A
V
S
S
V
N
A
T
Q
K
R
V
L
A
D
K
I
V
-
A
-
R
F
-
G
E
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
V
A
Q
E
E
A
R
R
V
------------
I
---------
A
L
D
L
A
DH
P
S
W
L
E
R
L
S
F
V
D
----
D
E
A
Q
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
-
G
R
L
W
K
T
P
V
I
F
D
G
R
N
L
Y
E
--
P
E
T
M
S
E
Q
G
I
E
Y
H
P
I
G
R
P
G
S
R
--------------------------
29
PsiBlast_CBE
81.85
44%
-34
- C3 -
2Y0D
6
?
C:
[11-461]
---
L
T
I
I
G
S
G
K
V
G
L
V
T
G
A
C
L
A
D
I
G
H
--
D
V
F
C
L
D
V
D
Q
A
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
R
N
R
S
A
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
-----
P
D
-----
S
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
F
K
V
I
V
D
K
S
T
V
P
V
G
T
A
E
R
V
R
A
A
V
A
E
E
L
A
K
R
G
---
G
D
---
Q
M
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
D
D
D
V
P
G
E
----
R
A
R
E
L
M
K
K
L
Y
A
P
F
NRN
H
E
---
R
---
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
H
F
L
Y
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
Q
S
--
L
Q
I
L
K
A
V
S
S
V
N
A
T
Q
K
R
V
L
A
D
K
I
V
-
A
-
R
F
-
G
E
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
V
A
Q
E
E
A
R
R
V
------------
I
---------
A
L
D
L
A
DH
P
S
W
L
E
R
L
S
F
V
D
----
D
E
A
Q
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
-
G
R
L
W
K
T
P
V
I
F
D
G
R
N
L
Y
E
--
P
E
T
M
S
E
Q
G
I
E
Y
H
P
I
G
R
P
G
----------------------------
112
HHSearch
81.13
45%
-27
- C3 -
2Y0C
11
?
A:
[8-463]
S
M
N
L
T
I
I
G
S
G
S
V
G
L
V
T
G
A
C
L
A
D
I
G
H
--
D
V
F
C
L
D
V
D
Q
A
K
I
D
I
L
N
N
G
G
V
P
I
H
E
P
G
L
K
E
V
I
A
R
N
R
S
A
G
R
L
R
F
S
T
D
I
E
A
A
V
A
H
G
D
V
Q
F
I
A
V
G
T
P
-----
P
D
-
E
-
D
G
S
A
D
L
Q
Y
V
L
A
A
A
R
N
I
G
R
Y
M
T
---
G
F
K
V
I
V
D
K
S
T
V
P
V
G
T
A
E
R
V
R
A
A
V
A
E
---
E
L
A
K
R
G
G
D
---
Q
M
F
S
V
V
S
N
P
E
F
L
K
E
G
A
A
V
D
D
F
T
R
P
D
R
I
V
I
G
C
D
D
----
D
V
P
G
E
R
A
R
E
L
M
K
K
L
Y
A
P
F
---
N
R
NHE
R
---
T
L
Y
M
D
V
R
S
A
E
F
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
E
L
A
N
L
A
D
R
F
G
A
D
I
E
A
V
R
R
G
I
G
S
D
P
R
I
G
Y
H
F
L
Y
A
G
C
G
Y
G
G
S
C
F
P
K
D
V
E
A
L
I
R
T
A
D
E
H
G
Q
S
--
L
Q
I
L
K
A
V
S
S
V
N
A
T
Q
K
R
V
L
A
D
K
I
V
-
A
R
F
G
-
E
-
D
L
T
G
R
T
F
A
I
W
G
L
A
F
K
P
N
T
D
D
M
R
E
A
P
S
R
E
L
I
A
E
L
L
S
R
G
A
R
I
A
A
Y
D
P
V
A
Q
E
E
A
R
R
V
I
A
L
D
L
A
DH
P
S
W
L
E
---------
R
------------
L
S
F
V
D
----
D
E
A
Q
A
A
R
D
A
D
A
L
V
I
V
T
E
W
K
I
F
K
S
P
D
F
V
A
L
-
G
R
L
W
K
T
P
V
I
F
D
G
R
N
L
Y
E
--
P
E
T
M
S
E
Q
G
I
E
Y
H
P
I
G
R
P
G
S
R
--------------------------
118
HHSearch
80.73
47%
-40
- C3 -
3GG2
4
?
A:
[2-436]
S
L
D
I
A
V
V
G
I
G
Y
V
G
L
V
S
A
T
C
F
A
E
L
G
A
--
N
V
R
C
I
D
T
D
R
N
K
I
E
Q
L
N
S
G
T
I
P
I
Y
E
P
G
L
E
K
M
I
A
R
N
V
K
A
G
R
L
R
F
G
T
E
I
E
Q
A
V
P
E
A
D
I
I
F
I
A
V
G
T
P
-----
A
G
-
E
-
D
G
S
A
D
M
S
Y
V
L
D
A
A
R
S
I
G
R
A
M
S
---
R
Y
I
L
I
V
T
K
S
T
V
P
V
G
S
Y
R
L
I
R
K
A
I
Q
E
E
L
D
K
R
E
---
V
L
---
I
D
F
D
I
A
S
N
P
E
F
L
K
E
G
N
A
I
D
D
F
M
K
P
D
R
V
V
V
G
V
D
S
----
D
----
R
A
R
E
L
I
T
S
L
Y
K
P
M
---
L
L
---
N
NFR
V
L
F
M
D
I
A
S
A
E
M
T
K
Y
A
A
N
A
M
L
A
T
R
I
S
F
M
N
D
V
A
N
L
C
E
R
V
G
A
D
V
S
M
V
R
L
G
I
G
S
D
S
R
I
G
S
K
F
L
Y
P
G
C
G
Y
G
G
S
C
F
P
K
D
V
K
A
L
I
R
T
A
E
D
N
G
Y
R
--
M
E
V
L
E
A
V
E
R
V
N
E
K
Q
K
S
I
L
F
D
K
F
S
-
T
Y
Y
K
-
G
-
N
V
Q
G
R
C
V
A
I
W
G
L
S
F
K
P
G
T
D
D
M
R
E
A
P
S
L
V
L
I
E
K
L
L
E
V
G
C
R
V
R
V
Y
D
P
V
A
M
K
E
A
Q
K
R
LG----------
D
---------
K
------------
V
E
Y
T
T
----
D
M
Y
D
A
V
R
G
A
E
A
L
F
H
V
T
E
W
K
E
F
R
M
P
D
W
S
A
L
-
S
Q
A
M
A
A
S
L
V
I
D
G
R
N
V
Y
E
--
L
P
------
F
T
L
L
N
I
G
-------------------------------
16
PsiBlast_PDB
76.45
35%
-30
- C3 -
3ITK
3
UGDH_HUMAN
A:
[5-465]
I
K
K
I
C
C
I
G
A
G
Y
V
G
G
P
T
C
S
V
I
A
H
M
C
P
E
I
R
V
T
V
V
D
V
N
E
S
R
I
N
A
W
N
S
P
T
L
P
I
Y
E
P
G
L
K
E
V
V
E
-
S
C
R
G
K
N
L
F
F
S
T
N
I
D
D
A
I
K
E
A
D
L
V
F
I
S
V
N
T
P
TKTYG
M
G
-
K
-
G
R
A
A
D
L
K
Y
I
E
A
C
A
R
R
I
V
Q
N
S
N
---
G
Y
K
I
V
T
E
K
S
A
V
P
V
R
A
A
E
S
I
R
R
I
F
D
A
---
N
T
K
---
P
N
---
L
N
L
Q
V
L
S
N
P
E
F
L
A
E
G
T
A
I
K
D
L
K
N
P
D
R
V
L
I
G
G
D
E
T
P
E
G
Q
----
R
A
V
Q
A
L
C
A
V
Y
E
H
W
VP-
R
E
---
K
---
I
L
T
T
N
T
W
S
S
E
L
S
K
L
A
A
N
A
F
L
A
Q
R
I
S
S
I
N
S
I
S
A
L
C
E
A
T
G
A
D
V
E
E
V
A
T
A
I
G
M
D
Q
R
I
G
N
K
F
L
K
A
S
V
G
F
G
G
S
C
F
Q
K
D
V
L
N
L
V
Y
L
C
E
A
L
N
L
P
E
V
A
R
Y
W
Q
Q
V
I
D
M
N
D
Y
Q
R
R
R
F
A
S
R
I
I
D
S
-
L
F
-
N
-
T
V
T
D
K
K
I
A
I
L
G
F
A
F
K
K
D
T
G
D
T
R
E
S
S
S
I
Y
I
S
K
Y
L
M
D
E
G
A
H
L
H
I
Y
D
P
-
K
V
P
R
E
Q
I
V
------------
V
D
L
SHPE---
D
----------
D
Q
V
S
R
L
V
T
I
S
K
D
P
Y
E
A
C
D
G
A
H
A
V
V
I
C
T
E
W
D
M
F
K
E
L
D
Y
E
R
I
H
K
K
M
L
K
P
A
F
I
F
D
G
R
R
V
L
D
GL
H
N
E
L
Q
T
I
G
F
Q
I
E
T
I
G
K
------------------------------
84
PsiBlast_CBE
76.30
35%
-27
- C3 -
3ITK
6
UGDH_HUMAN
D:
[5-465]
I
K
K
I
C
C
I
G
A
G
Y
V
G
G
P
T
C
S
V
I
A
H
M
C
P
EI
R
V
T
V
V
D
V
N
E
S
R
I
N
A
W
N
S
P
T
L
P
I
Y
E
P
G
L
K
E
V
V
E
-
S
C
R
G
K
N
L
F
F
S
T
N
I
D
D
A
I
K
E
A
D
L
V
F
I
S
V
N
T
P
TKTYG
M
G
-
K
-
G
R
A
A
D
L
K
Y
I
E
A
C
A
R
R
I
V
Q
N
S
N
---
G
Y
K
I
V
T
E
K
S
A
V
P
V
R
A
A
E
S
I
R
R
I
F
D
A
---
N
T
K
---
P
N
---
L
N
L
Q
V
L
S
N
P
E
F
L
A
E
G
T
A
I
K
D
L
K
N
P
D
R
V
L
I
G
G
D
E
TPEG
Q
----
R
A
V
Q
A
L
C
A
V
Y
E
H
W
VP-
R
E
---
K
---
I
L
T
T
N
T
W
S
S
E
L
S
K
L
A
A
N
A
F
L
A
Q
R
I
S
S
I
N
S
I
S
A
L
C
E
A
T
G
A
D
V
E
E
V
A
T
A
I
G
M
D
Q
R
I
G
N
K
F
L
K
A
S
V
G
F
G
G
S
C
F
Q
K
D
V
L
N
L
V
Y
L
C
E
A
L
N
L
P
EV
A
R
Y
W
Q
Q
V
I
D
M
N
D
Y
Q
R
R
R
F
A
S
R
I
I
D
S
-
L
F
-
N
-
T
V
T
D
K
K
I
A
I
L
G
F
A
F
K
K
D
T
G
D
T
R
E
S
S
S
I
Y
I
S
K
Y
L
M
D
E
G
A
H
L
H
I
Y
D
P
-
K
V
P
R
E
Q
I
V
------------
V
DLSHPGVSE
D
----------
D
Q
V
S
R
L
V
TISK
D
P
Y
E
A
C
D
G
A
H
A
V
V
I
C
T
E
W
D
M
F
K
E
L
D
Y
E
R
I
H
K
K
M
L
K
P
A
F
I
F
D
G
R
R
V
L
D
GL
H
N
E
L
Q
T
I
G
F
Q
I
E
T
I
G
K
------------------------------
83
PsiBlast_CBE
76.27
35%
-26
- C3 -
3ITK
3
UGDH_HUMAN
E:
[5-465]
I
K
K
I
C
C
I
G
A
G
Y
V
G
G
P
T
C
S
V
I
A
H
M
C
P
EI
R
V
T
V
V
D
V
N
E
S
R
I
N
A
W
N
S
P
T
L
P
I
Y
E
P
G
L
K
E
V
V
E
-
S
C
R
G
K
N
L
F
F
S
T
N
I
D
D
A
I
K
E
A
D
L
V
F
I
S
V
N
T
P
TKTYG
M
G
-
K
-
G
R
A
A
D
L
K
Y
I
E
A
C
A
R
R
I
V
Q
N
S
N
---
G
Y
K
I
V
T
E
K
S
A
V
P
V
R
A
A
E
S
I
R
R
I
F
D
A
---
N
T
K
---
P
N
---
L
N
L
Q
V
L
S
N
P
E
F
L
A
E
G
T
A
I
K
D
L
K
N
P
D
R
V
L
I
G
G
D
E
TPEG
Q
----
R
A
V
Q
A
L
C
A
V
Y
E
H
W
VP-
R
E
---
K
---
I
L
T
T
N
T
W
S
S
E
L
S
K
L
A
A
N
A
F
L
A
Q
R
I
S
S
I
N
S
I
S
A
L
C
E
A
T
G
A
D
V
E
E
V
A
T
A
I
G
M
D
Q
R
I
G
N
K
F
L
K
A
S
V
G
F
G
G
S
C
F
Q
K
D
V
L
N
L
V
Y
L
C
E
A
L
N
L
P
EV
A
R
Y
W
Q
Q
V
I
D
M
N
D
Y
Q
R
R
R
F
A
S
R
I
I
D
S
-
L
F
-
N
-
T
V
T
D
K
K
I
A
I
L
G
F
A
F
K
K
D
T
G
D
T
R
E
S
S
S
I
Y
I
S
K
Y
L
M
D
E
G
A
H
L
H
I
Y
D
P
-
K
V
P
R
E
Q
I
V
------------
V
DLSHPGVSE
D
----------
D
Q
V
S
R
L
V
TISK
D
P
Y
E
A
C
D
G
A
H
A
V
V
I
C
T
E
W
D
M
F
K
E
L
D
Y
E
R
I
H
K
K
M
L
K
P
A
F
I
F
D
G
R
R
V
L
D
GL
H
N
E
L
Q
T
I
G
F
Q
I
E
T
I
G
K
------------------------------
1
PsiBlast_PDB
76.11
48%
-11
- C3 -
4A7P
1
?
A:
[10-443]
--
R
I
A
M
I
G
T
G
Y
V
G
L
V
S
G
A
C
F
S
D
F
G
H
--
E
V
V
C
V
D
K
D
A
R
K
I
E
L
L
H
Q
N
V
M
P
I
Y
E
P
G
L
D
A
L
V
A
S
N
V
K
A
G
R
L
S
F
T
T
D
L
A
E
G
V
K
D
A
D
A
V
F
I
A
V
G
T
P
-----
S
R
-
R
G
D
G
H
A
D
L
S
Y
V
F
A
A
A
R
E
I
A
E
N
L
T
---
K
P
S
V
I
V
T
K
S
T
V
P
V
G
T
G
D
E
V
E
R
I
I
A
E
---
V
A
P
---
N
S
---
G
A
-
K
V
V
S
N
P
E
F
L
R
E
G
A
A
I
E
D
F
K
R
P
D
R
V
V
V
G
T
E
D
----
E
----
F
A
R
Q
V
M
R
E
I
Y
R
P
L
---
S
----
P
---
V
L
F
T
G
R
R
T
S
E
L
I
K
Y
A
A
N
A
F
L
A
V
K
I
T
F
I
N
E
I
A
D
L
C
E
Q
V
G
A
D
V
Q
E
V
S
R
G
I
G
M
D
N
R
I
---
F
L
H
A
G
P
G
Y
G
G
S
C
F
P
K
D
T
L
A
L
M
K
T
A
A
D
N
E
T
P
--
L
R
I
V
E
A
T
V
Q
V
N
D
A
R
K
R
A
M
G
R
K
V
I
-
K
-
A
M
G
G
-
D
V
R
G
K
T
V
G
I
L
G
L
T
F
K
P
N
T
D
D
M
R
D
A
P
S
L
S
I
I
A
A
L
Q
D
A
G
A
T
V
K
A
Y
D
P
E
G
V
E
Q
A
S
K
M
------------
L
---------
T
----------
D
-
V
E
F
V
E
----
N
P
Y
A
A
A
D
G
A
D
A
L
V
I
V
T
E
W
D
A
F
R
A
L
D
L
T
R
I
-
K
N
S
L
K
S
P
V
L
V
D
L
R
N
I
Y
P
--
P
A
E
L
E
R
A
G
L
Q
Y
T
G
V
G
K
P
-----------------------------
113
HHSearch
75.93
48%
-17
- C3 -
4A7P
1
?
A:
[8-443]
S
V
R
I
A
M
I
G
T
G
Y
V
G
L
V
S
G
A
C
F
S
D
F
G
H
--
E
V
V
C
V
D
K
D
A
R
K
I
E
L
L
H
Q
N
V
M
P
I
Y
E
P
G
L
D
A
L
V
A
S
N
V
K
A
G
R
L
S
F
T
T
D
L
A
E
G
V
K
D
A
D
A
V
F
I
A
V
G
T
P
-----
S
R
R
G
-
D
G
H
A
D
L
S
Y
V
F
A
A
A
R
E
I
A
E
N
L
T
---
K
P
S
V
I
V
T
K
S
T
V
P
V
G
T
G
D
E
V
E
R
I
I
A
E
---
V
A
----
P
N
---
S
G
A
K
V
V
S
N
P
E
F
L
R
E
G
A
A
I
E
D
F
K
R
P
D
R
V
V
V
G
T
E
D
----
E
----
F
A
R
Q
V
M
R
E
I
Y
R
P
L
---
S
----
P
---
V
L
F
T
G
R
R
T
S
E
L
I
K
Y
A
A
N
A
F
L
A
V
K
I
T
F
I
N
E
I
A
D
L
C
E
Q
V
G
A
D
V
Q
E
V
S
R
G
I
G
M
D
N
R
I
---
F
L
H
A
G
P
G
Y
G
G
S
C
F
P
K
D
T
L
A
L
M
K
T
A
A
D
N
E
T
P
--
L
R
I
V
E
A
T
V
Q
V
N
D
A
R
K
R
A
M
G
R
K
V
I
-
K
A
M
G
-
G
-
D
V
R
G
K
T
V
G
I
L
G
L
T
F
K
P
N
T
D
D
M
R
D
A
P
S
L
S
I
I
A
A
L
Q
D
A
G
A
T
V
K
A
Y
D
P
E
G
V
E
Q
A
S
K
M
L-----------
T
---------
D
------------
V
E
F
V
E
----
N
P
Y
A
A
A
D
G
A
D
A
L
V
I
V
T
E
W
D
A
F
R
A
L
D
L
T
R
I
-
K
N
S
L
K
S
P
V
L
V
D
L
R
N
I
Y
P
--
P
A
E
L
E
R
A
G
L
Q
Y
T
G
V
G
K
P
-----------------------------
116
HHSearch
74.38
39%
-49
- C3 -
3VTF
2
?
A:
[21-443]
M
A
S
L
S
V
L
G
L
G
Y
V
G
V
V
H
A
V
G
F
A
L
L
G
H
--
R
V
V
G
Y
D
V
N
P
S
I
V
E
R
L
R
A
G
R
P
H
I
Y
E
P
G
L
E
E
A
L
G
R
A
L
S
S
G
R
L
S
F
A
E
S
A
E
E
A
V
A
A
T
D
A
T
F
I
A
V
G
T
P
-----
P
A
-
P
-
D
G
S
A
D
L
R
Y
V
E
A
A
A
R
A
V
G
R
G
I
R
A
K
G
R
W
H
L
V
V
V
K
S
T
V
P
P
G
T
T
E
G
L
V
A
R
A
V
A
---
E
E
A
---
G
G
---
V
K
F
S
V
A
S
N
P
E
F
L
R
E
G
S
A
L
E
D
F
F
K
P
D
R
I
V
I
G
A
G
D
----
E
----
R
A
A
S
F
L
L
D
V
Y
K
A
V
---
D
A
---
P
---
K
L
V
M
K
P
R
E
A
E
L
V
K
Y
A
S
N
V
F
L
A
L
K
I
S
F
A
N
E
V
G
L
L
A
K
R
L
G
V
D
T
Y
R
V
F
E
A
V
G
L
D
K
R
I
G
R
H
Y
F
G
A
G
L
G
F
G
G
S
C
F
P
K
D
T
L
A
F
I
R
F
G
E
S
L
G
L
E
--
M
A
I
S
K
A
V
L
R
V
N
E
Y
M
P
R
Y
A
V
Q
L
L
E
-
E
-
R
L
-
G
-
G
L
R
G
R
H
V
G
V
L
G
L
A
F
K
P
N
T
D
D
V
R
E
S
R
G
V
E
V
A
R
L
L
L
E
R
G
A
R
V
Y
V
H
D
P
M
A
M
E
K
A
R
A
V
------------
L
---------
G
----------
D
S
V
T
Y
V
E
----
D
P
Q
A
L
L
D
Q
V
E
G
V
I
I
A
T
A
W
P
Q
Y
E
G
L
D
Y
--------
R
G
K
V
V
V
D
G
R
Y
V
K
K
--
A
R
----
E
A
K
I
Y
E
G
V
A
W
------------------------------