@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu35680: (2016-07-30 )
MKRTWNVCLTALLSVLLVAGSVPFHAEAKKPPKSYDEYKQVDVGKDGMVATAHALASEIGADVLKKGGNAIDAAVAIQFALNVTEPMMSGIGGGGFMMVYDGKTKDTTIIDSRERAPAGATPDMFLDENGKAIPFSERVTKGTAVGVPGTLKGLEEALDKWGTRSMKLLITLTIKLAEKGFPIDSVLADAISDYQEKLSRTAAKDVFLPNGEPLKEGDTLIQKDLAKTFKLIRSKGTDAFYKGKFAKTLSDTVQDFGGSMTEKDLENYDITIDEPIWGDYQGYQIATTPPPSSGGIFLLQMLKILDDFNLSQYDVRSWEKYQLLAETMHLSYADRASYAGDPEFVNVPLKGLLHPDYIKERQQLINLDQVNKKPKAGDPWKYQEGSANYKQVEQPKDKVEGQTTHFTVADRWGNVVSYTTTIEQLFGTGIMVPDYGVILNNELTDFDAIPGGANEVQPNKRPLSSMTPTILFKDDKPVLTVGSPGGATIISSVLQTILYHIEYGMGLKAAVEEPRIYTTSMSSYRYEDGVPKDVLSKLNGMGHRFGTSPVDIGNVQSISIDHENGTFKGVVISGSNDAAIGINLKRK
Atome Classification :
(26 SA)
.........10........20........30....--..--.---.40........50........60........70........80........90........100.......110.......120.......130..-....-.140........150.......160.......170.......180.......190...-..-.--.200----.-.-.......210.-.......220.......230.......240.......250.......260.......270........280.......290.......300.......310..----.....320--.........330.......340......--.350.......360.......370.......380.......390.......400.......410.......420...-....430.......440.......450.......460.......470.......480.......490.......500.......510.......520---.-.......-530.......540.....--..550.......560.......570.......580.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
R
T
W
N
V
C
L
T
A
L
L
S
V
L
L
V
AGSVPFHAEAKKPPKS
Y
--
D
E
--
Y
---KQVDVGKD
G
M
V
A
T
A
H
A
L
A
S
E
I
G
A
D
V
L
K
KGGN
A
I
D
A
A
V
A
I
Q
F
A
LNV
T
E
P
M
M
SGIGGG
G
F
M
M
V
YDGKTKD
T
T
I
IDSRERAPAGATP
D
M
F
LDENGKAIP-FSER-VTK-GTAVGVP
G
T
L
K
G
L
E
E
A
L
D
KWGTR
S
M
K
L
L
I
T
L
T
I
K
LAEKGF
P
I
D
S
V
L
A
D
A
I
S
D
Y
Q
-
E
K
-
L
--
S
R
------
T
-A-AK
D
V
FLPN-GE-PLKEG
D
T
L
I
Q
K
D
L
A
K
T
F
K
L
I
R
SKGTD
A
F
YK
G
K
F
A
K
T
L
S
D
T
V
Q
D
FGGSM
T
E
K
D
LENY
D
I
T
-IDEPIWGDYQ
G
Y
Q
I
A
TTPPPSS
G
G
I
F
L
L
Q
M
L
K
I
L
D
DFNLS
Q
Y
D
----
V
R
S
W
E
K
----
Y
Q
L
L
A
E
T
M
HLSYADRASYAGDP
E
F
V
NV
P
--
L
K
GLL
H
P
D
Y
I
K
E
R
Q
Q
L
I
N
L
D
QVNKKPKAGDPWKYQEGSAN
Y
K
Q
VEQ
P
K
D
KVEGQT
T
H
F
T
V
ADRWG
N
V
V
S
Y
T
T
T
I
E
Q
L
-FGTGIMVPD
Y
G
V
I
LNNELTDFDAIPGGANEVQPNKRPLSSMT
P
T
I
L
F
KDDK
P
V
L
T
VGSPG
G
A
T
I
I
S
S
V
L
Q
T
I
L
Y
H
I
EYGMGLKAAVEEP
R
I
Y
T
TSM----S-SYRYEDG-V
P
K
D
V
L
S
K
L
N
GMGHRFGT--SPVDIGN
V
Q
S
I
S
I
DHENG
T
F
K
G
V
V
I
SGSN
D
A
A
I
G
I
NLKRK
1
PsiBlast_PDB
82.12
73%
-57
- C2 -
4Y23
1
?
A:
[36-581]
----------------------------------------------
K
V
A
V
G
K
D
G
M
V
A
T
A
H
P
L
A
S
K
I
G
A
E
V
L
K
K
G
G
N
A
I
D
A
A
I
A
I
Q
Y
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
M
M
V
Y
D
G
E
T
K
E
T
S
I
I
N
S
R
E
R
A
P
E
G
A
K
P
D
M
F
L
D
E
D
G
K
V
I
P
-
F
S
E
R
-
S
R
H
-
G
N
A
V
G
V
P
G
T
L
K
G
L
E
A
A
H
K
K
W
G
T
K
K
M
E
D
L
I
S
P
S
I
K
L
T
E
E
G
F
P
I
D
S
V
L
A
D
A
I
K
D
H
Q
-
D
K
-
L
--
S
K
------
T
-
A
-
A
K
D
I
F
L
P
D
-
G
E
-
P
L
K
E
G
D
I
L
V
Q
K
D
M
A
K
T
F
K
L
I
R
K
E
G
S
K
A
F
Y
D
G
E
I
G
R
A
I
A
D
V
V
Q
D
F
G
G
S
M
T
P
D
D
L
S
R
Y
E
V
T
-
T
D
K
P
I
W
G
E
Y
H
G
Y
D
I
A
S
M
P
P
P
S
S
G
G
V
F
M
L
Q
M
L
K
L
I
D
D
F
H
L
S
Q
Y
D
----
P
K
S
F
E
K
----
Y
H
L
L
A
E
T
M
H
L
S
Y
A
D
R
A
A
Y
A
G
D
P
E
F
V
D
V
P
--
L
R
G
L
L
D
P
D
Y
I
K
E
R
Q
K
L
I
S
L
D
S
M
N
R
D
V
K
E
G
D
P
W
K
Y
E
E
G
E
P
N
Y
E
I
V
P
Q
P
E
D
K
T
I
G
E
A
T
H
F
T
V
T
D
Q
W
G
N
V
V
S
Y
T
T
T
I
E
Q
L
-
F
G
T
G
I
L
V
P
G
Y
G
L
F
L
N
N
E
L
T
D
F
D
A
I
P
G
G
A
N
E
V
Q
P
N
K
R
P
L
S
S
M
T
P
T
I
V
F
K
D
E
K
P
V
L
T
V
G
S
P
G
G
T
T
I
I
A
S
V
F
Q
T
I
L
N
Y
F
E
Y
G
M
S
L
Q
D
A
I
E
E
P
R
I
Y
T
N
S
L
----
T
-
S
Y
R
Y
E
S
G
-
M
P
E
D
V
R
R
K
L
N
D
F
G
H
K
F
G
S
--
N
P
V
D
I
G
N
V
Q
S
I
F
I
D
R
E
N
K
T
F
M
G
V
A
D
S
S
R
N
G
T
A
V
G
V
N
I
K
--
60
HHSearch
80.56
73%
-39
- C2 -
4Y23
1
?
A:
[35-582]
---------------------------------------------
D
K
V
A
V
G
K
D
G
M
V
A
T
A
H
P
L
A
S
K
I
G
A
E
V
L
K
K
G
G
N
A
I
D
A
A
I
A
I
Q
Y
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
M
M
V
Y
D
G
E
T
K
E
T
S
I
I
N
S
R
E
R
A
P
E
G
A
K
P
D
M
F
L
D
E
D
G
K
V
I
P
-
F
S
E
R
-
S
R
H
-
G
N
A
V
G
V
P
G
T
L
K
G
L
E
A
A
H
K
K
W
G
T
K
K
M
E
D
L
I
S
P
S
I
K
L
T
E
E
G
F
P
I
D
S
V
L
A
D
A
I
K
D
H
Q
-
D
K
-
L
--
S
K
------
T
-
A
-
A
K
D
I
F
L
P
D
-
G
E
-
P
L
K
E
G
D
I
L
V
Q
K
D
M
A
K
T
F
K
L
I
R
K
E
G
S
K
A
F
Y
D
G
E
I
G
R
A
I
A
D
V
V
Q
D
F
G
G
S
M
T
P
D
D
L
S
R
Y
E
V
T
-
T
D
K
P
I
W
G
E
Y
H
G
Y
D
I
A
S
M
P
P
P
S
S
G
G
V
F
M
L
Q
M
L
K
L
I
D
D
F
H
L
S
Q
Y
D
----
P
K
S
F
E
K
----
Y
H
L
L
A
E
T
M
H
L
S
Y
A
D
R
A
A
Y
A
G
D
P
E
F
V
D
V
P
--
L
R
G
L
L
D
P
D
Y
I
K
E
R
Q
K
L
I
S
L
D
S
M
N
R
D
V
K
E
G
D
P
W
K
Y
E
E
G
E
P
N
Y
E
I
V
P
Q
P
E
D
K
T
I
G
E
A
T
H
F
T
V
T
D
Q
W
G
N
V
V
S
Y
T
T
T
I
E
-
Q
L
F
G
T
G
I
L
V
P
G
Y
G
L
F
L
N
N
E
L
T
D
F
D
A
I
P
G
G
A
N
E
V
Q
P
N
K
R
P
L
S
S
M
T
P
T
I
V
F
K
D
E
K
P
V
L
T
V
G
S
P
G
G
T
T
I
I
A
S
V
F
Q
T
I
L
N
Y
F
E
Y
G
M
S
L
Q
D
A
I
E
E
P
R
I
Y
T
N
S
L
----
T
-
S
Y
R
Y
E
S
G
-
M
P
E
D
V
R
R
K
L
N
D
F
G
H
K
F
G
S
--
N
P
V
D
I
G
N
V
Q
S
I
F
I
D
R
E
N
K
T
F
M
G
V
A
D
S
S
R
N
G
T
A
V
G
V
N
I
K
T
-
3
PsiBlast_PDB
65.31
98%
-61
- C2 -
3WHR
-
?
A:
[37-395]
--------------------------------------
E
--
Y
---
K
Q
V
D
V
G
K
D
G
M
V
A
T
A
H
P
L
A
S
E
I
G
A
D
V
L
K
K
G
G
N
A
I
D
A
A
V
A
I
Q
F
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
M
M
V
Y
D
G
K
T
K
D
T
T
I
I
D
S
R
E
R
A
P
A
G
A
T
P
D
M
F
L
D
E
N
G
K
A
I
P
-
F
S
E
R
-
V
T
K
-
G
T
A
V
G
V
P
G
T
L
K
G
L
E
E
A
L
D
K
W
G
T
R
S
M
K
Q
L
I
T
P
S
I
K
L
A
E
K
G
F
P
I
D
S
V
L
A
E
A
I
S
D
Y
Q
-
E
K
-
L
--
S
R
------
T
-
A
-
A
K
D
V
F
L
P
N
-
G
E
-
P
L
K
E
G
D
T
L
I
Q
K
D
L
A
K
T
F
K
L
I
R
S
K
G
T
D
A
F
Y
K
G
K
F
A
K
T
L
S
D
T
V
Q
D
F
G
G
S
M
T
E
K
D
L
E
N
Y
D
I
T
-
I
D
E
P
I
W
G
D
Y
Q
G
Y
Q
I
A
T
T
P
P
P
S
S
G
G
I
F
L
L
Q
M
L
K
I
L
D
H
F
N
L
S
Q
Y
D
----
V
R
S
W
E
K
----
Y
Q
L
L
A
E
T
M
H
L
S
Y
A
D
R
A
S
Y
A
G
D
P
E
F
V
N
V
P
--
L
K
G
L
L
H
P
D
Y
I
K
E
R
Q
Q
L
I
N
L
D
Q
V
N
K
K
P
K
A
G
D
P
W
K
Y
Q
E
G
S
A
N
Y
K
Q
V
E
Q
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
65.06
97%
-60
- C2 -
3A75
1
?
A:
[19-377]
--------------------------------------
E
--
Y
---
K
Q
V
D
V
G
K
D
G
M
V
A
T
A
H
P
L
A
S
E
I
G
A
D
V
L
K
K
G
G
N
A
I
D
A
A
V
A
I
Q
F
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
M
M
V
Y
D
G
K
T
K
D
T
T
I
I
D
S
R
E
R
A
P
A
G
A
T
P
D
M
F
L
D
E
N
G
K
A
I
P
-
F
S
E
R
-
V
T
K
-
G
T
A
V
G
V
P
G
T
L
K
G
L
E
E
A
L
D
K
W
G
T
R
S
M
K
Q
L
I
T
P
S
I
K
L
A
E
K
G
F
P
I
D
S
V
L
A
E
A
I
S
D
Y
Q
-
E
K
-
L
--
S
R
------
T
-
A
-
A
K
D
V
F
L
P
N
-
G
E
-
P
L
K
E
G
D
T
L
I
Q
K
D
L
A
K
T
F
K
L
I
R
S
K
G
T
D
A
F
Y
K
G
K
F
A
K
T
L
S
D
T
V
Q
D
F
G
G
S
M
T
E
K
D
L
E
N
Y
D
I
T
-
I
D
E
P
I
W
G
D
Y
Q
G
Y
Q
I
A
T
T
P
P
P
S
S
G
G
I
F
L
L
Q
M
L
K
I
L
D
H
F
N
L
S
Q
Y
D
----
V
R
S
W
E
K
----
Y
Q
L
L
A
E
T
M
H
L
S
Y
A
D
R
A
S
Y
A
G
D
P
E
F
V
N
V
P
--
L
K
G
L
L
H
P
D
Y
I
K
E
R
Q
Q
L
I
N
L
D
Q
V
N
K
K
P
K
A
G
D
P
W
K
Y
Q
E
G
S
A
N
Y
K
Q
V
E
Q
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
65.05
98%
-60
- C2 -
3WHS
1
GGT_BACSU
A:
[53-411]
--------------------------------------
E
--
Y
---
K
Q
V
D
V
G
K
D
G
M
V
A
T
A
H
P
L
A
S
E
I
G
A
D
V
L
K
K
G
G
N
A
I
D
A
A
V
A
I
Q
F
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
M
M
V
Y
D
G
K
T
K
D
T
T
I
I
D
S
R
E
R
A
P
A
G
A
T
P
D
M
F
L
D
E
N
G
K
A
I
P
-
F
S
E
R
-
V
T
K
-
G
T
A
V
G
V
P
G
T
L
K
G
L
E
E
A
L
D
K
W
G
T
R
S
M
K
Q
L
I
T
P
S
I
K
L
A
E
K
G
F
P
I
D
S
V
L
A
E
A
I
S
D
Y
Q
-
E
K
-
L
--
S
R
------
T
-
A
-
A
K
D
V
F
L
P
N
-
G
E
-
P
L
K
E
G
D
T
L
I
Q
K
D
L
A
K
T
F
K
L
I
R
S
K
G
T
D
A
F
Y
K
G
K
F
A
K
T
L
S
D
T
V
Q
D
F
G
G
S
M
T
E
K
D
L
E
N
Y
D
I
T
-
I
D
E
P
I
W
G
D
Y
Q
G
Y
Q
I
A
T
T
P
P
P
S
S
G
G
I
F
L
L
Q
M
L
K
I
L
D
H
F
N
L
S
Q
Y
D
----
V
R
S
W
E
K
----
Y
Q
L
L
A
E
T
M
H
L
S
Y
A
D
R
A
S
Y
A
G
D
P
E
F
V
N
V
P
--
L
K
G
L
L
H
P
D
Y
I
K
E
R
Q
Q
L
I
N
L
D
Q
V
N
K
K
P
K
A
G
D
P
W
K
Y
Q
E
G
S
A
N
Y
K
Q
V
E
Q
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
64.93
98%
-60
- C2 -
3WHQ
-
GGT_BACSU
A:
[37-396]
--------------------------------------
E
--
Y
---
K
Q
V
D
V
G
K
D
G
M
V
A
T
A
H
P
L
A
S
E
I
G
A
D
V
L
K
K
G
G
N
A
I
D
A
A
V
A
I
Q
F
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
M
M
V
Y
D
G
K
T
K
D
T
T
I
I
D
S
R
E
R
A
P
A
G
A
T
P
D
M
F
L
D
E
N
G
K
A
I
P
-
F
S
E
R
-
V
T
K
-
G
T
A
V
G
V
P
G
T
L
K
G
L
E
E
A
L
D
K
W
G
T
R
S
M
K
Q
L
I
T
P
S
I
K
L
A
E
K
G
F
P
I
D
S
V
L
A
E
A
I
S
D
Y
Q
-
E
K
-
L
--
S
R
------
T
-
A
-
A
K
D
V
F
L
P
N
-
G
E
-
P
L
K
E
G
D
T
L
I
Q
K
D
L
A
K
T
F
K
L
I
R
S
K
G
T
D
A
F
Y
K
G
K
F
A
K
T
L
S
D
T
V
Q
D
F
G
G
S
M
T
E
K
D
L
E
N
Y
D
I
T
-
I
D
E
P
I
W
G
D
Y
Q
G
Y
Q
I
A
T
T
P
P
P
S
S
G
G
I
F
L
L
Q
M
L
K
I
L
D
H
F
N
L
S
Q
Y
D
----
V
R
S
W
E
K
----
Y
Q
L
L
A
E
T
M
H
L
S
Y
A
D
R
A
S
Y
A
G
D
P
E
F
V
N
V
P
--
L
K
G
L
L
H
P
D
Y
I
K
E
R
Q
Q
L
I
N
L
D
Q
V
N
K
K
P
K
A
G
D
P
W
K
Y
Q
E
G
S
A
N
Y
K
Q
V
E
Q
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
64.74
98%
-56
- C2 -
2V36
-
GGT_BACSU
A:
[34-394]
---------------------------------
S
Y
--
D
E
--
Y
---
K
Q
V
D
V
G
K
D
G
M
V
A
T
A
H
P
L
A
S
E
I
G
A
D
V
L
K
K
G
G
N
A
I
D
A
A
V
A
I
Q
F
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
M
M
V
Y
D
G
K
T
K
D
T
T
I
I
D
S
R
E
R
A
P
A
G
A
T
P
D
M
F
L
D
E
N
G
K
A
I
P
-
F
S
E
R
-
V
T
K
-
G
T
A
V
G
V
P
G
T
L
K
G
L
E
E
A
L
D
K
W
G
T
R
S
M
K
Q
L
I
T
P
S
I
K
L
A
E
K
G
F
P
I
D
S
V
L
A
E
A
I
S
D
Y
Q
-
E
K
-
L
--
S
R
------
T
-
A
-
A
K
D
V
F
L
P
N
-
G
E
-
P
L
K
E
G
D
T
L
I
Q
K
D
L
A
K
T
F
K
L
I
R
S
K
G
T
D
A
F
Y
K
G
K
F
A
K
T
L
S
D
T
V
Q
D
F
G
G
S
M
T
E
K
D
L
E
N
Y
D
I
T
-
I
D
E
P
I
W
G
D
Y
Q
G
Y
Q
I
A
T
T
P
P
P
S
S
G
G
I
F
L
L
Q
M
P
K
I
L
D
H
F
N
L
S
--
D
----
V
R
S
W
E
K
----
Y
Q
L
L
A
E
T
M
H
L
S
Y
A
D
R
A
S
Y
A
G
D
P
E
F
V
N
V
P
--
L
K
G
L
L
H
P
D
Y
I
K
E
R
Q
Q
L
I
N
L
D
Q
V
N
K
K
P
K
A
G
D
P
W
K
Y
Q
E
G
S
A
N
Y
K
Q
V
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
64.25
97%
-56
- C2 -
3A75
1
?
C:
[20-377]
-----------------------------------------
Y
---
K
Q
V
D
V
G
K
D
G
M
V
A
T
A
H
P
L
A
S
E
I
G
A
D
V
L
K
K
G
G
N
A
I
D
A
A
V
A
I
Q
F
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
M
M
V
Y
D
G
K
T
K
D
T
T
I
I
D
S
R
E
R
A
P
A
G
A
T
P
D
M
F
L
D
E
N
G
K
A
I
P
-
F
S
E
R
-
V
T
K
-
G
T
A
V
G
V
P
G
T
L
K
G
L
E
E
A
L
D
K
W
G
T
R
S
M
K
Q
L
I
T
P
S
I
K
L
A
E
K
G
F
P
I
D
S
V
L
A
E
A
I
S
D
Y
Q
-
E
K
-
L
--
S
R
------
T
-
A
-
A
K
D
V
F
L
P
N
-
G
E
-
P
L
K
E
G
D
T
L
I
Q
K
D
L
A
K
T
F
K
L
I
R
S
K
G
T
D
A
F
Y
K
G
K
F
A
K
T
L
S
D
T
V
Q
D
F
G
G
S
M
T
E
K
D
L
E
N
Y
D
I
T
-
I
D
E
P
I
W
G
D
Y
Q
G
Y
Q
I
A
T
T
P
P
P
S
S
G
G
I
F
L
L
Q
M
L
K
I
L
D
H
F
N
L
S
Q
Y
D
----
V
R
S
W
E
K
----
Y
Q
L
L
A
E
T
M
H
L
S
Y
A
D
R
A
S
Y
A
G
D
P
E
F
V
N
V
P
--
L
K
G
L
L
H
P
D
Y
I
K
E
R
Q
Q
L
I
N
L
D
Q
V
N
K
K
P
K
A
G
D
P
W
K
Y
Q
E
G
S
A
N
Y
K
Q
V
E
Q
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
HHSearch
63.28
98%
-73
- C2 -
3WHR
-
?
A:
[37-371]
--------------------------------------
E
--
Y
---
K
Q
V
D
V
G
K
D
G
M
V
A
T
A
H
P
L
A
S
E
I
G
A
D
V
L
K
K
G
G
N
A
I
D
A
A
V
A
I
Q
F
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
M
M
V
Y
D
G
K
T
K
D
T
T
I
I
D
S
R
E
R
A
P
A
G
A
T
P
D
M
F
L
D
E
N
G
K
A
I
P
-
F
S
E
R
-
V
T
K
-
G
T
A
V
G
V
P
G
T
L
K
G
L
E
E
A
L
D
K
W
G
T
R
S
M
K
Q
L
I
T
P
S
I
K
L
A
E
K
G
F
P
I
D
S
V
L
A
E
A
I
S
D
Y
Q
-
E
K
-
L
--
S
R
------
T
-
A
-
A
K
D
V
F
L
P
N
-
G
E
-
P
L
K
E
G
D
T
L
I
Q
K
D
L
A
K
T
F
K
L
I
R
S
K
G
T
D
A
F
Y
K
G
K
F
A
K
T
L
S
D
T
V
Q
D
F
G
G
S
M
T
E
K
D
L
E
N
Y
D
I
T
-
I
D
E
P
I
W
G
D
Y
Q
G
Y
Q
I
A
T
T
P
P
P
S
S
G
G
I
F
L
L
Q
M
L
K
I
L
D
H
F
N
L
S
Q
Y
D
----
V
R
S
W
E
K
----
Y
Q
L
L
A
E
T
M
H
L
S
Y
A
D
R
A
S
Y
A
G
D
P
E
F
V
N
V
P
--
L
K
G
L
L
H
P
D
Y
I
K
E
R
Q
Q
L
I
N
L
D
Q
V
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
59.41
73%
-56
- C2 -
4OTU
1
?
A:
[36-397]
----------------------------------------------
K
V
A
V
G
K
D
G
M
V
A
T
A
H
P
L
A
S
K
I
G
A
E
V
L
K
K
G
G
N
A
I
D
A
A
I
A
I
Q
Y
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
M
M
V
Y
D
G
E
T
K
E
T
S
I
I
N
S
R
E
R
A
P
E
G
A
K
P
D
M
F
L
D
E
D
G
K
V
I
P
-
F
S
E
R
-
S
R
H
-
G
N
A
V
G
V
P
G
T
L
K
G
L
E
A
A
H
K
K
W
G
T
K
K
M
E
D
L
I
S
P
S
I
K
L
T
E
E
G
F
P
I
D
S
V
L
A
D
A
I
K
D
H
Q
-
D
K
-
L
--
S
K
------
T
-
A
-
A
K
D
I
F
L
P
D
-
G
E
-
P
L
K
E
G
D
I
L
V
Q
K
D
M
A
K
T
F
K
L
I
R
K
E
G
S
K
A
F
Y
D
G
E
I
G
R
A
I
A
D
V
V
Q
D
F
G
G
S
M
T
P
D
D
L
S
R
Y
E
V
T
-
T
D
K
P
I
W
G
E
Y
H
G
Y
D
I
A
S
M
P
P
P
S
S
G
G
V
F
M
L
Q
M
L
K
L
I
D
D
F
H
L
S
Q
Y
D
----
P
K
S
F
E
K
----
Y
H
L
L
A
E
T
M
H
L
S
Y
A
D
R
A
A
Y
A
G
D
P
E
F
V
D
V
P
--
L
R
G
L
L
D
P
D
Y
I
K
E
R
Q
K
L
I
S
L
D
S
M
N
R
D
V
K
E
G
D
P
W
K
Y
E
E
G
E
P
N
Y
E
I
V
P
Q
P
E
D
K
T
I
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
58.55
73%
-60
- C2 -
4OTT
1
?
A:
[36-391]
----------------------------------------------
K
V
A
V
G
K
D
G
M
V
A
T
A
H
P
L
A
S
K
I
G
A
E
V
L
K
K
G
G
N
A
I
D
A
A
I
A
I
Q
Y
A
L
N
V
T
E
P
M
M
S
G
I
G
G
G
G
F
M
M
V
Y
D
G
E
T
K
E
T
S
I
I
N
S
R
E
R
A
P
E
G
A
K
P
D
M
F
L
D
E
D
G
K
V
I
P
-
F
S
E
R
-
S
R
H
-
G
N
A
V
G
V
P
G
T
L
K
G
L
E
A
A
H
K
K
W
G
T
K
K
M
E
D
L
I
S
P
S
I
K
L
T
E
E
G
F
P
I
D
S
V
L
A
D
A
I
K
D
H
Q
-
D
K
-
L
--
S
K
------
T
-
A
-
A
K
D
I
F
L
P
D
-
G
E
-
P
L
K
E
G
D
I
L
V
Q
K
D
M
A
K
T
F
K
L
I
R
K
E
G
S
K
A
F
Y
D
G
E
I
G
R
A
I
A
D
V
V
Q
D
F
G
G
S
M
T
P
D
D
L
S
R
Y
E
V
T
-
T
D
K
P
I
W
G
E
Y
H
G
Y
D
I
A
S
M
P
P
P
S
S
G
G
V
F
M
L
Q
M
L
K
L
I
D
D
F
H
L
S
Q
Y
D
----
P
K
S
F
E
K
----
Y
H
L
L
A
E
T
M
H
L
S
Y
A
D
R
A
A
Y
A
G
D
P
E
F
V
D
V
P
--
L
R
G
L
L
D
P
D
Y
I
K
E
R
Q
K
L
I
S
L
D
S
M
N
R
D
V
K
E
G
D
P
W
K
Y
E
E
G
E
P
N
Y
E
I
V
P
Q
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
HHSearch
51.41
23%
-13
- C2 -
2I3O
-
?
A:
[5-515]
---------------------------------------------
R
P
N
A
L
S
Q
R
S
V
I
A
S
S
S
E
L
A
S
L
A
G
R
D
I
L
K
R
G
G
N
I
F
D
A
A
L
A
V
S
A
M
L
C
V
T
Q
N
N
L
C
G
L
G
G
D
L
F
A
L
I
R
D
E
N
-
G
Q
I
M
D
L
N
G
S
G
Q
A
S
R
A
V
S
I
D
Y
Y
E
S
M
G
L
---
T
-
K
I
P
E
-
R
G
P
-
Y
A
A
I
T
V
P
G
I
A
G
S
W
D
E
I
F
R
K
F
A
T
M
D
I
A
D
I
L
E
P
A
I
R
T
A
S
A
G
F
P
I
T
Q
N
Y
S
D
S
I
A
R
S
A
-
P
V
-
I
--
G
Q
------
Y
-
R
G
W
S
S
I
F
M
P
N
-
G
S
-
V
P
V
A
G
E
I
L
K
Q
P
D
L
A
E
S
F
R
L
M
S
E
E
G
F
R
S
F
Y
D
G
S
L
A
D
I
I
I
A
G
L
E
G
T
G
S
P
L
S
D
R
D
L
R
V
Y
R
P
L
-
I
G
K
P
V
F
T
D
L
D
E
F
R
I
Y
E
T
S
P
N
S
Q
G
I
T
V
-
I
E
W
I
R
G
M
E
S
H
G
Y
D
S
R
T
-----
M
W
E
A
K
----
I
E
D
I
F
E
T
M
E
E
A
Y
D
K
R
R
-
K
I
T
D
P
S
Y
M
N
-------------------
G
L
-------------
P
K
--------------
R
D
H
N
D
I
G
D
T
T
Y
F
S
I
S
D
S
E
G
R
S
V
S
I
I
Q
S
N
Y
-
M
G
F
G
S
G
I
V
P
K
G
T
G
F
V
L
Q
N
R
G
S
Y
F
T
L
Q
R
D
H
P
N
A
L
M
P
G
K
R
T
F
H
T
L
A
A
C
M
V
E
K
E
H
D
L
Y
A
S
L
G
S
M
G
G
D
I
Q
P
Q
V
Q
M
Q
I
L
M
E
I
L
K
D
N
T
D
P
Q
A
I
L
D
K
P
R
W
T
E
P
Y
T
IYEA
P
G
A
V
Y
V
E
S
E
E
L
Y
R
N
V
S
K
Q
I
S
G
R
K
V
V
L
R
D
--
V
S
Q
E
F
G
T
A
Q
I
T
T
L
I
-
R
G
D
V
V
V
G
A
A
D
P
R
G
D
G
I
A
I
P
Y
-----
62
HHSearch
50.35
28%
19
- C- -
2NLZ
-
?
A:
[7-540]
-------------------------------
P
Q
S
Y
--
P
Y
P
S
R
---
R
N
V
V
Y
A
K
N
G
M
V
A
T
S
Q
P
L
A
A
Q
A
G
L
D
I
L
K
A
G
G
N
A
I
D
A
A
I
A
T
A
T
A
L
T
V
L
E
P
T
S
N
G
I
G
S
D
A
F
A
L
V
W
T
K
G
--
K
L
H
G
L
N
G
S
G
R
A
P
M
S
L
T
M
E
A
V
K
A
K
G
Y
---
E
-
Q
E
L
P
-
P
Y
G
-
V
I
P
V
T
V
P
G
A
P
G
A
W
A
E
L
A
K
M
Y
G
N
L
P
L
A
A
S
L
A
P
A
I
R
Y
A
E
E
G
Y
P
V
T
P
T
L
A
K
Y
W
K
A
A
Y
-
D
R
-
V
--
K
T
EWTDDV
Y
-
Q
P
W
F
D
T
F
A
P
K
-
G
R
-
A
P
R
V
G
E
V
W
R
S
Q
G
H
A
D
T
L
R
S
I
A
E
S
N
G
E
S
F
Y
R
G
E
L
A
D
Q
I
H
A
F
F
D
K
H
G
G
Y
L
T
K
E
D
L
A
C
Y
R
P
E
-
W
V
E
P
I
S
I
D
Y
R
G
Y
R
V
W
E
I
P
P
N
G
Q
G
L
V
A
-
L
E
A
L
N
I
V
K
G
F
E
F
Y
H
K
------
D
T
V
D
T
----
Y
H
K
Q
I
E
A
M
K
L
A
F
V
D
G
M
K
Y
V
T
E
P
S
D
M
S
V
S
--
V
E
Q
L
L
S
D
E
Y
A
T
E
R
R
K
E
I
G
E
Q
A
L
T
-------
P
E
---
P
-----------
G
T
P
----
T
V
Y
L
A
T
A
D
G
D
G
N
M
V
S
F
I
Q
S
N
Y
-
M
G
F
G
S
G
V
V
V
P
G
T
G
I
A
M
Q
N
R
G
H
N
F
S
L
D
P
N
H
D
N
A
L
K
P
G
K
R
T
Y
H
T
I
I
P
G
F
L
T
K
N
D
Q
P
I
G
P
F
G
V
M
G
G
F
M
Q
P
Q
G
H
M
Q
V
M
M
N
T
I
D
F
G
L
N
P
Q
A
A
L
D
A
P
R
W
Q
W
T
N
G
----
K
-
Q
V
Q
V
E
P
T
-
F
P
V
D
I
A
Q
A
L
V
R
R
G
H
K
I
Q
V
V
L
D
E
G
A
F
G
R
G
Q
I
I
W
R
D
P
T
T
G
V
L
A
G
G
T
E
P
R
T
D
G
Q
V
A
A
W
E
----
68
HHSearch
43.92
34%
-89
- C2 -
3G9K
-
CAPD_BACAN
L:
[18-309]
--------------------------------------------------
K
G
T
Y
G
V
S
A
S
H
P
L
A
V
E
E
G
M
K
V
L
K
N
G
G
S
A
V
D
A
A
I
V
V
S
Y
V
L
G
V
V
E
L
H
A
S
G
I
G
G
G
G
G
M
L
I
I
S
K
D
--
K
E
T
F
I
D
Y
R
E
T
T
P
Y
---------------------------
P
H
I
G
V
P
G
F
V
A
G
M
E
Y
I
H
D
N
Y
G
S
L
P
M
G
E
L
L
Q
P
A
I
N
Y
A
E
K
G
F
K
V
D
D
S
L
T
M
R
L
D
L
A
K
-
P
R
-
I
--
Y
S
--------
D
-
K
L
S
I
F
Y
P
N
-
G
E
-
P
I
E
T
G
E
T
L
I
Q
T
D
L
A
R
T
L
K
K
I
Q
K
E
G
A
K
G
F
Y
E
G
G
V
A
R
A
I
S
K
-----
T
A
K
I
S
L
E
D
I
K
G
Y
K
V
E
-
V
R
K
P
V
K
G
N
Y
M
G
Y
D
V
Y
T
A
P
P
P
F
S
G
V
T
L
-
L
Q
M
L
K
L
A
E
K
K
E
V
Y
K
D
V
----
D
H
T
A
T
Y
----
M
S
K
M
E
E
I
S
R
I
A
Y
Q
D
R
K
K
N
L
G
------
M
D
--
P
N
K
M
V
S
D
K
Y
I
S
T
M
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
HHSearch
43.38
38%
-2
* C2 *
2QMC
1
?
A:
[30-360]
-----------------------------------------------
I
K
N
T
K
V
G
L
A
L
S
S
H
P
L
A
S
E
I
G
Q
K
V
L
E
E
G
G
N
A
I
D
A
A
V
A
I
G
F
A
L
A
V
V
H
P
A
A
G
N
I
G
G
G
G
F
A
V
I
H
L
A
N
-
G
E
N
V
A
L
D
F
R
E
K
A
P
L
K
A
T
K
N
M
F
L
D
K
Q
G
N
V
-
V
-
P
K
L
S
-
E
D
G
-
Y
L
A
A
G
V
P
G
T
V
A
G
M
E
A
M
L
K
K
Y
G
T
K
K
L
S
Q
L
I
D
P
A
I
K
L
A
E
N
G
Y
A
I
S
Q
R
Q
A
E
T
L
K
E
A
R
-
E
R
-
F
--
L
K
------
Y
-
S
S
S
K
K
Y
F
F
K
K
G
H
L
-
D
Y
Q
E
G
D
L
F
V
Q
K
D
L
A
K
T
L
N
Q
I
K
T
L
G
A
K
G
F
Y
Q
G
Q
V
A
E
L
I
E
K
D
M
K
K
N
G
G
I
I
T
K
E
D
L
A
S
Y
N
V
K
-
W
R
K
P
V
V
G
S
Y
R
G
Y
K
I
I
S
M
S
P
P
S
S
G
G
T
H
L
I
Q
I
L
N
V
M
E
N
A
D
L
S
A
L
G
----
Y
G
A
S
K
N
----
I
H
I
A
A
E
A
M
R
Q
A
Y
A
D
R
S
V
Y
M
G
D
A
D
F
V
S
V
P
--
V
D
K
L
I
N
K
A
Y
A
K
K
I
F
D
T
I
Q
P
D
T
V
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
HHSearch
43.23
29%
-40
- C2 -
4GDX
10
GGT1_HUMAN
A:
[33-363]
---------------------------------------------
P
D
N
H
V
Y
T
R
A
A
V
A
A
D
A
K
Q
C
S
K
I
G
R
D
A
L
R
D
G
G
S
A
V
D
A
A
I
A
A
L
L
C
V
G
L
M
N
A
H
S
M
G
I
G
G
G
L
F
L
T
I
Y
N
S
T
T
R
K
A
E
V
I
N
A
R
E
V
A
P
R
L
A
F
A
T
M
F
N
S
S
E
--------
Q
S
-
Q
K
G
-
G
L
S
V
A
V
P
G
E
I
R
G
Y
E
L
A
H
Q
R
H
G
R
L
P
W
A
R
L
F
Q
P
S
I
Q
L
A
R
Q
G
F
P
V
G
K
G
L
A
A
A
L
E
N
K
R
-
T
V
-
I
--
E
Q
------
Q
-
P
V
L
C
E
V
F
C
R
D
-
R
K
-
V
L
R
E
G
E
R
L
T
L
P
Q
L
A
D
T
Y
E
T
L
A
I
E
G
A
Q
A
F
Y
N
G
S
L
T
A
Q
I
V
K
D
I
Q
A
A
G
G
I
V
T
A
E
D
L
N
N
Y
R
A
E
L
I
E
H
P
L
N
I
S
L
G
D
A
V
L
Y
M
P
S
A
P
L
S
G
P
V
L
-
A
L
I
L
N
I
L
K
G
Y
N
F
S
R
E
S
VES
P
E
Q
K
G
L
T
----
Y
H
R
I
V
E
A
F
R
F
A
Y
A
K
R
T
-
L
L
G
D
P
K
F
V
D
V
T
E
V
V
R
N
M
T
S
E
F
F
A
A
Q
L
R
A
Q
I
S
D
D
T
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
43.17
43%
25
- C2 -
2Z8I
1
?
C:
[15-348]
-------------------------------------
D
V
--
F
---
H
P
V
R
A
-
K
Q
G
M
V
A
S
V
D
A
T
A
T
Q
V
G
V
D
I
L
K
E
G
G
N
A
V
D
A
A
V
A
V
G
Y
A
L
A
V
T
H
P
Q
A
G
N
L
G
G
G
G
F
M
L
I
R
S
-
K
N
G
N
T
T
A
I
D
F
R
E
M
A
P
A
K
A
T
R
D
M
F
L
D
D
Q
G
N
--
P
-
D
S
K
K
S
L
T
S
-
H
L
A
S
G
T
P
G
T
V
A
G
F
S
L
A
L
D
K
Y
G
T
M
P
L
N
K
V
V
Q
P
A
F
K
L
A
R
D
G
F
I
V
N
D
A
L
A
D
D
L
K
T
Y
G
-
S
E
-
V
LP
N
H
------
E
-
N
-
S
K
A
I
F
W
K
E
-
G
E
-
P
L
K
K
G
D
T
L
V
Q
A
N
L
A
K
S
L
E
M
I
A
E
N
G
P
D
E
F
Y
K
G
T
I
A
E
Q
I
A
Q
E
M
Q
K
N
G
G
L
I
T
K
E
D
L
A
A
Y
K
A
V
-
E
R
T
P
I
S
G
D
Y
R
G
Y
Q
V
Y
S
M
P
P
P
S
S
G
G
I
H
I
V
Q
I
L
N
I
L
E
N
F
D
M
K
K
Y
G
----
F
G
S
A
D
A
----
M
Q
I
M
A
E
A
E
K
Y
A
Y
A
D
R
S
E
Y
L
G
D
P
D
F
V
K
V
P
--
W
Q
A
L
T
N
K
A
Y
A
K
S
I
A
D
Q
I
D
I
N
K
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
HHSearch
42.96
44%
27
- C2 -
2DG5
2
?
A:
[13-348]
-----------------------------------------
E
EDV
F
H
P
V
R
A
K
Q
G
M
V
A
S
V
D
A
T
A
T
Q
V
G
V
D
I
L
K
E
G
G
N
A
V
D
A
A
V
A
V
G
Y
A
L
A
V
T
H
P
Q
A
G
N
L
G
G
G
G
F
M
L
I
R
S
K
N
-
G
N
T
T
A
I
D
F
R
E
M
A
P
A
K
A
T
R
D
M
F
L
D
D
Q
G
N
P
-
D
-
S
K
K
S
-
L
T
S
-
H
L
A
S
G
T
P
G
T
V
A
G
F
S
L
A
L
D
K
Y
G
T
M
P
L
N
K
V
V
Q
P
A
F
K
L
A
R
D
G
F
I
V
N
D
A
L
A
D
D
L
K
T
Y
G
S
E
V
-
L
--
P
N
------
H
-
E
N
S
K
A
I
F
W
K
E
-
G
E
-
P
L
K
K
G
D
T
L
V
Q
A
N
L
A
K
S
L
E
M
I
A
E
N
G
P
D
E
F
Y
K
G
T
I
A
E
Q
I
A
Q
E
M
Q
K
N
G
G
L
I
T
K
E
D
L
A
A
Y
K
A
V
-
E
R
T
P
I
S
G
D
Y
R
G
Y
Q
V
Y
S
M
P
P
P
S
S
G
G
I
H
I
V
Q
I
L
N
I
L
E
N
F
D
M
K
K
Y
G
----
F
G
S
A
D
A
----
M
Q
I
M
A
E
A
E
K
Y
A
Y
A
D
R
S
E
Y
L
G
D
P
D
F
V
K
V
P
--
W
Q
A
L
T
N
K
A
Y
A
K
S
I
A
D
Q
I
D
I
N
K
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
42.90
40%
23
- C2 -
3FNM
1
?
A:
[29-359]
----------------------------------------------
P
I
K
N
T
K
V
G
L
A
L
S
S
H
P
L
A
S
E
I
G
Q
K
V
L
E
E
G
G
N
A
I
D
A
A
V
A
I
G
F
A
L
A
V
V
H
P
A
A
G
N
I
G
G
G
G
F
A
V
I
H
L
A
N
G
E
N
V
A
L
-
D
F
R
E
K
A
P
L
K
A
T
K
N
M
F
L
D
K
Q
G
N
V
V
P
K
L
S
E
D
-
G
Y
---
L
A
A
G
V
P
G
T
V
A
G
M
E
A
M
L
K
K
Y
G
T
K
K
L
S
Q
L
I
D
P
A
I
K
L
A
E
N
G
Y
A
I
S
Q
R
Q
A
E
T
L
K
E
A
R
-
E
R
F
L
--
K
Y
------
S
-
S
-
S
K
K
Y
F
F
K
K
-
G
H
L
D
Y
Q
E
G
D
L
F
V
Q
K
D
L
A
K
T
L
N
Q
I
K
T
L
G
A
K
G
F
Y
Q
G
Q
V
A
E
L
I
E
K
D
M
K
K
N
G
G
I
I
T
K
E
D
L
A
S
Y
N
V
K
-
W
R
K
P
V
V
G
S
Y
R
G
Y
K
I
I
S
M
S
P
P
S
S
G
G
T
H
L
I
Q
I
L
N
V
M
E
N
A
D
L
S
A
L
G
----
Y
G
A
S
K
N
----
I
H
I
A
A
E
A
M
R
Q
A
Y
A
D
R
S
V
Y
M
G
D
A
D
F
V
S
V
P
--
V
D
K
L
I
N
K
A
Y
A
K
K
I
F
D
T
I
Q
P
D
T
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
42.77
42%
26
- C2 -
2DG5
2
?
A:
[13-348]
-----------------------------------EE
D
V
--
F
---
H
P
V
R
A
-
K
Q
G
M
V
A
S
V
D
A
T
A
T
Q
V
G
V
D
I
L
K
E
G
G
N
A
V
D
A
A
V
A
V
G
Y
A
L
A
V
T
H
P
Q
A
G
N
L
G
G
G
G
F
M
L
I
R
-
S
K
N
G
N
T
T
A
I
D
F
R
E
M
A
P
A
K
A
T
R
D
M
F
L
D
D
Q
G
N
--
P
-
D
S
K
K
S
L
T
S
-
H
L
A
S
G
T
P
G
T
V
A
G
F
S
L
A
L
D
K
Y
G
T
M
P
L
N
K
V
V
Q
P
A
F
K
L
A
R
D
G
F
I
V
N
D
A
L
A
D
D
L
K
T
Y
G
-
S
E
-
V
LP
N
H
------
E
-
N
-
S
K
A
I
F
W
K
E
-
G
E
-
P
L
K
K
G
D
T
L
V
Q
A
N
L
A
K
S
L
E
M
I
A
E
N
G
P
D
E
F
Y
K
G
T
I
A
E
Q
I
A
Q
E
M
Q
K
N
G
G
L
I
T
K
E
D
L
A
A
Y
K
A
V
-
E
R
T
P
I
S
G
D
Y
R
G
Y
Q
V
Y
S
M
P
P
P
S
S
G
G
I
H
I
V
Q
I
L
N
I
L
E
N
F
D
M
K
K
Y
G
----
F
G
S
A
D
A
----
M
Q
I
M
A
E
A
E
K
Y
A
Y
A
D
R
S
E
Y
L
G
D
P
D
F
V
K
V
P
--
W
Q
A
L
T
N
K
A
Y
A
K
S
I
A
D
Q
I
D
I
N
K
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
42.56
40%
23
- C2 -
2QM6
1
?
C:
[30-359]
-----------------------------------------------
I
K
N
T
K
V
G
L
A
L
S
S
H
P
L
A
S
E
I
G
Q
K
V
L
E
E
G
G
N
A
I
D
A
A
V
A
I
G
F
A
L
A
V
V
H
P
A
A
G
N
I
G
G
G
G
F
A
V
I
H
L
A
N
G
E
N
V
A
L
-
D
F
R
E
K
A
P
L
K
A
T
K
N
M
F
L
D
K
Q
G
N
V
V
P
K
L
S
E
D
-
G
Y
---
L
A
A
G
V
P
G
T
V
A
G
M
E
A
M
L
K
K
Y
G
T
K
K
L
S
Q
L
I
D
P
A
I
K
L
A
E
N
G
Y
A
I
S
Q
R
Q
A
E
T
L
K
E
A
R
-
E
R
F
L
--
K
Y
------
S
-
S
-
S
K
K
Y
F
F
K
K
-
G
H
L
D
Y
Q
E
G
D
L
F
V
Q
K
D
L
A
K
T
L
N
Q
I
K
T
L
G
A
K
G
F
Y
Q
G
Q
V
A
E
L
I
E
K
D
M
K
K
N
G
G
I
I
T
K
E
D
L
A
S
Y
N
V
K
-
W
R
K
P
V
V
G
S
Y
R
G
Y
K
I
I
S
M
S
P
P
S
S
G
G
T
H
L
I
Q
I
L
N
V
M
E
N
A
D
L
S
A
L
G
----
Y
G
A
S
K
N
----
I
H
I
A
A
E
A
M
R
Q
A
Y
A
D
R
S
V
Y
M
G
D
A
D
F
V
S
V
P
--
V
D
K
L
I
N
K
A
Y
A
K
K
I
F
D
T
I
Q
P
D
T
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
42.56
40%
24
- C2 -
3FNM
1
?
C:
[30-359]
-----------------------------------------------
I
K
N
T
K
V
G
L
A
L
S
S
H
P
L
A
S
E
I
G
Q
K
V
L
E
E
G
G
N
A
I
D
A
A
V
A
I
G
F
A
L
A
V
V
H
P
A
A
G
N
I
G
G
G
G
F
A
V
I
H
L
A
N
G
E
N
V
A
L
-
D
F
R
E
K
A
P
L
K
A
T
K
N
M
F
L
D
K
Q
G
N
V
V
P
K
L
S
E
D
-
G
Y
---
L
A
A
G
V
P
G
T
V
A
G
M
E
A
M
L
K
K
Y
G
T
K
K
L
S
Q
L
I
D
P
A
I
K
L
A
E
N
G
Y
A
I
S
Q
R
Q
A
E
T
L
K
E
A
R
-
E
R
F
L
--
K
Y
------
S
-
S
-
S
K
K
Y
F
F
K
K
-
G
H
L
D
Y
Q
E
G
D
L
F
V
Q
K
D
L
A
K
T
L
N
Q
I
K
T
L
G
A
K
G
F
Y
Q
G
Q
V
A
E
L
I
E
K
D
M
K
K
N
G
G
I
I
T
K
E
D
L
A
S
Y
N
V
K
-
W
R
K
P
V
V
G
S
Y
R
G
Y
K
I
I
S
M
S
P
P
S
S
G
G
T
H
L
I
Q
I
L
N
V
M
E
N
A
D
L
S
A
L
G
----
Y
G
A
S
K
N
----
I
H
I
A
A
E
A
M
R
Q
A
Y
A
D
R
S
V
Y
M
G
D
A
D
F
V
S
V
P
--
V
D
K
L
I
N
K
A
Y
A
K
K
I
F
D
T
I
Q
P
D
T
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
42.40
40%
27
- C2 -
2QM6
1
?
A:
[30-359]
-----------------------------------------------
I
K
N
T
K
V
G
L
A
L
S
S
H
P
L
A
S
E
I
G
Q
K
V
L
E
E
G
G
N
A
I
D
A
A
V
A
I
G
F
A
L
A
V
V
H
P
A
A
G
N
I
G
G
G
G
F
A
V
I
H
L
A
N
G
E
N
V
A
L
-
D
F
R
E
K
A
P
L
K
A
T
K
N
M
F
L
D
K
Q
G
N
V
V
P
K
L
S
E
D
-
G
Y
---
L
A
A
G
V
P
G
T
V
A
G
M
E
A
M
L
K
K
Y
G
T
K
K
L
S
Q
L
I
D
P
A
I
K
L
A
E
N
G
Y
A
I
S
Q
R
Q
A
E
T
L
K
E
A
R
-
E
R
F
L
--
K
Y
------
S
-
S
-
S
K
K
Y
F
F
K
K
-
G
H
L
D
Y
Q
E
G
D
L
F
V
Q
K
D
L
A
K
T
L
N
Q
I
K
T
L
G
A
K
G
F
Y
Q
G
Q
V
A
E
L
I
E
K
D
M
K
K
N
G
G
I
I
T
K
E
D
L
A
S
Y
N
V
K
-
W
R
K
P
V
V
G
S
Y
R
G
Y
K
I
I
S
M
S
P
P
S
S
G
G
T
H
L
I
Q
I
L
N
V
M
E
N
A
D
L
S
A
L
G
----
Y
G
A
S
K
N
----
I
H
I
A
A
E
A
M
R
Q
A
Y
A
D
R
S
V
Y
M
G
D
A
D
F
V
S
V
P
--
V
D
K
L
I
N
K
A
Y
A
K
K
I
F
D
T
I
Q
P
D
T
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
42.16
40%
25
- C2 -
2QMC
1
?
C:
[30-359]
-----------------------------------------------
I
K
N
T
K
V
G
L
A
L
S
S
H
P
L
A
S
E
I
G
Q
K
V
L
E
E
G
G
N
A
I
D
A
A
V
A
I
G
F
A
L
A
V
V
H
P
A
A
G
N
I
G
G
G
G
F
A
V
I
H
L
A
N
G
E
N
V
A
L
-
D
F
R
E
K
A
P
L
K
A
T
K
N
M
F
L
D
K
Q
G
N
V
V
P
K
L
S
E
D
-
G
Y
---
L
A
A
G
V
P
G
T
V
A
G
M
E
A
M
L
K
K
Y
G
T
K
K
L
S
Q
L
I
D
P
A
I
K
L
A
E
N
G
Y
A
I
S
Q
R
Q
A
E
T
L
K
E
A
R
-
E
R
F
L
--
K
Y
------
S
-
S
-
S
K
K
Y
F
F
K
K
-
G
H
L
D
Y
Q
E
G
D
L
F
V
Q
K
D
L
A
K
T
L
N
Q
I
K
T
L
G
A
K
G
F
Y
Q
G
Q
V
A
E
L
I
E
K
D
M
K
K
N
G
G
I
I
T
K
E
D
L
A
S
Y
N
V
K
-
W
R
K
P
V
V
G
S
Y
R
G
Y
K
I
I
S
M
S
P
P
S
S
G
G
T
H
L
I
Q
I
L
N
V
M
E
N
A
D
L
S
A
L
G
----
Y
G
A
S
K
N
----
I
H
I
A
A
E
A
M
R
Q
A
Y
A
D
R
S
V
Y
M
G
D
A
D
F
V
S
V
P
--
V
D
K
L
I
N
K
A
Y
A
K
K
I
F
D
T
I
Q
P
D
T
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
42.16
40%
25
- C2 -
2QMC
1
?
A:
[30-359]
-----------------------------------------------
I
K
N
T
K
V
G
L
A
L
S
S
H
P
L
A
S
E
I
G
Q
K
V
L
E
E
G
G
N
A
I
D
A
A
V
A
I
G
F
A
L
A
V
V
H
P
A
A
G
N
I
G
G
G
G
F
A
V
I
H
L
A
N
G
E
N
V
A
L
-
D
F
R
E
K
A
P
L
K
A
T
K
N
M
F
L
D
K
Q
G
N
V
V
P
K
L
S
E
D
-
G
Y
---
L
A
A
G
V
P
G
T
V
A
G
M
E
A
M
L
K
K
Y
G
T
K
K
L
S
Q
L
I
D
P
A
I
K
L
A
E
N
G
Y
A
I
S
Q
R
Q
A
E
T
L
K
E
A
R
-
E
R
F
L
--
K
Y
------
S
-
S
-
S
K
K
Y
F
F
K
K
-
G
H
L
D
Y
Q
E
G
D
L
F
V
Q
K
D
L
A
K
T
L
N
Q
I
K
T
L
G
A
K
G
F
Y
Q
G
Q
V
A
E
L
I
E
K
D
M
K
K
N
G
G
I
I
T
K
E
D
L
A
S
Y
N
V
K
-
W
R
K
P
V
V
G
S
Y
R
G
Y
K
I
I
S
M
S
P
P
S
S
G
G
T
H
L
I
Q
I
L
N
V
M
E
N
A
D
L
S
A
L
G
----
Y
G
A
S
K
N
----
I
H
I
A
A
E
A
M
R
Q
A
Y
A
D
R
S
V
Y
M
G
D
A
D
F
V
S
V
P
--
V
D
K
L
I
N
K
A
Y
A
K
K
I
F
D
T
I
Q
P
D
T
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
37.35
32%
11
- C2 -
4GDX
6
GGT1_HUMAN
A:
[50-338]
--------------------------------------------------------------
C
S
K
I
G
R
D
A
L
R
D
G
G
S
A
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---------
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