@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu35910: (2016-07-30 )
MATIKDVAGAAGVSVATVSRNLNDNGYVHEETRTRVIAAMAKLNYYPNEVARSLYKRESRLIGLLLPDITNPFFPQLARGAEDELNREGYRLIFGNSDEELKKELEYLQTFKQNHVAGIIAATNYPDLEEYSGMNYPVVFLDRTLEGAPSVSSDGYTGVKLAAQAIIHGKSQRITLLRGPAHLPTAQDRFNGALEILKQAEVDFQVIETASFSIKDAQSMAKELFASYPATDGVIASNDIQAAAVLHEALRRGKNVPEDIQIIGYDDIPQSGLLFPPLSTIKQPAYDMGKEAAKLLLGIIKKQPLAETAIQMPVTYIGRKTTRKED
Atome Classification :
(24 SA)
.........10........20........30........40........50........60........70........80........90........100.......110......-.120-.......-----..-130.-.......140..--.--.-..---.150.......160.......170.......180.....-.-.190.......200..---..--.---....210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MA
T
I
K
D
VAGAAG
V
S
V
A
T
V
SRNLNDN
G
Y
V
H
E
E
T
R
T
R
V
I
A
A
M
A
KLNY
Y
P
N
E
V
A
R
S
L
Y
K
R
E
S
R
L
I
G
L
LLPDITN
P
F
F
P
Q
L
ARGA
E
D
ELNREG
Y
R
L
I
FGNS
D
E
E
L
K
K
E
L
E
Y
L
Q
T
F
K
QNH
V
A
G
-
I
I
---AATNYP
D
-----
L
E
-
E
-YS-GMNY
P
V
V
F
LDRT--L--E-GA---PSVSSDGY
T
G
V
K
L
A
A
Q
A
I
IHGKS
Q
R
I
T
L
L
RGPAHLP
T
A
Q
-
D
-
R
F
N
G
A
L
E
I
L
K
QA--EV---
D
F
--
Q
---
V
I
E
TASFS
I
K
D
A
Q
S
M
A
K
E
L
F
A
SYPATD
G
V
I
ASN
D
I
Q
A
A
A
V
L
H
E
A
L
R
RGKNVPE
D
I
Q
I
I
GYDDIPQSGLLFP
P
L
S
T
I
K
Q
P
A
Y
D
M
G
K
E
A
A
K
L
L
L
G
I
I
KKQ
P
L
A
E
T
A
I
QM
P
V
T
Y
IGRKTTRKED
10
PsiBlast_PDB
81.34
30%
-13
- C2 -
2PUA
2
PURR_ECOLI
A:
[1-330]
-
A
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
---
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
-
Y
R
---
H
I
P
M
V
V
M
D
W
G
--
E
--
A
-
K
A
DF
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
A
N
T
G
A
-
G
-
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
---
P
E
--
S
---
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
----
13
PsiBlast_PDB
80.80
30%
-12
- C2 -
2PUD
2
PURR_ECOLI
A:
[2-330]
--
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
---
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
-
Y
R
---
H
I
P
M
V
V
M
D
W
G
--
E
--
A
-
K
A
DF
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
A
N
T
G
A
-
G
-
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
---
P
E
--
S
---
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
----
17
PsiBlast_PDB
80.64
30%
-12
- C2 -
1BDH
2
PURR_ECOLI
A:
[2-330]
--
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
A
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
---
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
-
Y
R
---
H
I
P
M
V
V
M
D
W
G
--
E
--
A
-
K
A
DF
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
T
G
A
-
G
-
R
L
A
G
F
M
K
A
M
E
E
A
MI
K
V
---
P
E
--
S
---
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
----
9
PsiBlast_PDB
80.38
30%
-7
- C2 -
1JH9
4
PURR_ECOLI
A:
[1-330]
-
A
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
---
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
-
Y
R
---
H
I
P
M
V
V
M
D
R
G
--
E
--
A
-
K
A
DF
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
T
G
A
-
G
-
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
---
P
E
--
S
---
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
----
18
PsiBlast_PDB
80.20
30%
-11
- C2 -
1QP7
2
PURR_ECOLI
A:
[2-330]
--
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
A
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
---
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
-
Y
R
---
H
I
P
M
V
V
M
D
W
G
--
E
--
A
-
K
A
DF
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
T
G
A
-
G
-
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
---
P
E
--
S
---
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
----
16
PsiBlast_PDB
80.16
30%
-12
- C2 -
2PUG
2
PURR_ECOLI
A:
[2-330]
--
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
---
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
-
Y
R
---
H
I
P
M
V
V
M
D
W
G
--
E
--
A
-
K
A
DF
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
Q
N
T
G
A
-
G
-
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
---
P
E
--
S
---
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
----
24
PsiBlast_CBE
79.94
31%
-20
- C2 -
3OQM
4
CCPA_BACSU
C:
[4-332]
--
T
I
Y
D
V
A
R
E
A
N
V
S
M
A
T
V
S
R
V
V
N
G
N
P
N
V
K
P
T
T
R
K
K
V
L
E
A
I
E
R
L
G
Y
R
P
N
A
V
A
R
G
L
A
S
K
K
T
T
T
V
G
V
I
I
P
D
I
S
S
I
F
Y
S
E
L
A
R
G
I
E
D
I
A
T
M
Y
K
Y
N
I
I
L
S
N
S
D
Q
N
M
E
K
E
L
H
L
L
N
T
M
L
G
K
Q
V
D
G
-
I
V
F--
M
G
G
N
I
T
D
EH---
V
A
-
E
-
F
K
-
R
S
P
V
P
I
V
L
A
A
S
V
EE
Q
--
E
-
E
T
---
P
S
V
A
I
D
Y
E
Q
A
I
Y
D
A
V
K
L
L
V
D
K
G
H
T
D
I
A
F
V
S
G
P
M
A
E
P
I
N
R
-
S
K
K
L
Q
G
Y
K
R
A
L
E
E
A
--
N
L
---
P
F
NE
Q
---
F
V
A
E
G
D
Y
T
Y
D
S
G
L
E
A
L
Q
H
L
M
S
L
D
K
K
P
T
A
I
L
S
A
T
D
E
M
A
L
G
I
I
H
A
A
Q
D
Q
G
L
S
I
P
E
D
L
D
I
I
G
F
D
N
T
R
L
S
L
M
V
R
P
Q
L
S
T
V
V
Q
P
T
Y
D
I
G
A
V
A
M
R
L
L
T
K
L
M
N
K
E
P
V
E
E
H
I
V
E
L
P
H
R
I
E
L
R
K
S
T
K
---
11
PsiBlast_PDB
79.87
30%
-10
- C2 -
2PUB
2
PURR_ECOLI
A:
[2-330]
--
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
---
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
-
Y
R
---
H
I
P
M
V
V
M
D
W
G
--
E
--
A
-
K
A
DF
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
A
N
T
G
A
-
G
-
R
L
A
G
F
M
K
A
M
E
E
A
MI
K
V
---
P
E
--
S
---
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
----
2
PsiBlast_PDB
79.87
31%
-20
- C2 -
3OQO
4
CCPA_BACSU
A:
[4-332]
--
T
I
Y
D
V
A
R
E
A
N
V
S
M
A
T
V
S
R
V
V
N
G
N
P
N
V
K
P
T
T
R
K
K
V
L
E
A
I
E
R
L
G
Y
R
P
N
A
V
A
R
G
L
A
S
K
K
T
T
T
V
G
V
I
I
P
D
I
S
S
I
F
Y
S
E
L
A
R
G
I
E
D
I
A
T
M
Y
K
Y
N
I
I
L
S
N
S
D
Q
N
M
E
K
E
L
H
L
L
N
T
M
L
G
K
Q
V
D
G
-
I
V
F
--
M
G
G
N
I
T
D
E
H
---
V
A
-
E
-
F
K
-
R
S
P
V
P
I
V
L
A
A
S
V
EE
Q
--
E
-
E
T
---
P
S
V
A
I
D
Y
E
Q
A
I
Y
D
A
V
K
L
L
V
D
K
G
H
T
D
I
A
F
V
S
G
P
M
A
E
P
I
N
R
-
S
K
K
L
Q
G
Y
K
R
A
L
E
E
A
--
N
L
---
P
F
N
E
Q
---
F
V
A
E
G
D
Y
T
Y
D
S
G
L
E
A
L
Q
H
L
M
S
L
D
K
K
P
T
A
I
L
S
A
T
D
E
M
A
L
G
I
I
H
A
A
Q
D
Q
G
L
S
I
P
E
D
L
D
I
I
G
F
D
N
T
R
L
S
L
M
V
R
P
Q
L
S
T
V
V
Q
P
T
Y
D
I
G
A
V
A
M
R
L
L
T
K
L
M
N
K
E
P
V
E
E
H
I
V
E
L
P
H
R
I
E
L
R
K
S
T
K
---
14
PsiBlast_PDB
79.57
30%
-8
- C2 -
2PUE
2
PURR_ECOLI
A:
[2-330]
--
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
---
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
-
Y
R
---
H
I
P
M
V
V
M
D
W
G
--
E
--
A
-
K
A
DF
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
Q
N
T
G
A
-
G
-
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
---
P
E
--
S
---
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
----
12
PsiBlast_PDB
79.55
30%
-14
- C2 -
2PUC
2
PURR_ECOLI
A:
[2-330]
--
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
---
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
-
Y
R
---
H
I
P
M
V
V
M
D
W
G
--
E
--
A
-
K
A
DF
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
A
N
T
G
A
-
G
-
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
---
P
E
--
S
---
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
----
58
HHSearch
79.10
28%
-21
- C2 -
1QPZ
2
PURR_ECOLI
A:
[1-333]
-
A
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
-
L
L
---
V
M
C
S
E
Y
P
E
----
P
L
L
A
M
L
E
E
Y
R
H
I
P
M
V
V
M
D
W
G
--
E
AK
A
D
F
T
---
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
T
G
A
-
G
-
R
L
A
G
F
M
K
A
M
E
E
A
--
M
I
---
K
V
--
P
ESW
I
V
Q
G
-
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
A
D
G
-
3
PsiBlast_PDB
79.01
31%
-16
- C2 -
3OQM
4
CCPA_BACSU
A:
[4-332]
--
T
I
Y
D
V
A
R
E
A
N
V
S
M
A
T
V
S
R
V
V
N
G
N
P
N
V
K
P
T
T
R
K
K
V
L
E
A
I
E
R
L
G
Y
R
P
N
A
V
A
R
G
L
A
S
K
K
T
T
T
V
G
V
I
I
P
D
I
S
S
I
F
Y
S
E
L
A
R
G
I
E
D
I
A
T
M
Y
K
Y
N
I
I
L
S
N
S
D
Q
N
M
E
K
E
L
H
L
L
N
T
M
L
G
K
Q
V
D
G
-
I
V
F
--
M
G
G
N
I
T
D
E
H
---
V
A
-
E
-
F
K
-
R
S
P
V
P
I
V
L
A
A
S
V
EE
Q
--
E
-
E
T
---
P
S
V
A
I
D
Y
E
Q
A
I
Y
D
A
V
K
L
L
V
D
K
G
H
T
D
I
A
F
V
S
G
P
M
A
E
P
I
N
R
-
S
K
K
L
Q
G
Y
K
R
A
L
E
E
A
--
N
L
---
P
F
N
E
Q
---
F
V
A
E
G
D
Y
T
Y
D
S
G
L
E
A
L
Q
H
L
M
S
L
D
K
K
P
T
A
I
L
S
A
T
D
E
M
A
L
G
I
I
H
A
A
Q
D
Q
G
L
S
I
P
E
D
L
D
I
I
G
F
D
N
T
R
L
S
L
M
V
R
P
Q
L
S
T
V
V
Q
P
T
Y
D
I
G
A
V
A
M
R
L
L
T
K
L
M
N
K
E
P
V
E
E
H
I
V
E
L
P
H
R
I
E
L
R
K
S
T
K
---
15
PsiBlast_PDB
78.86
30%
-11
- C2 -
2PUF
2
PURR_ECOLI
A:
[2-330]
--
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
K
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
---
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
-
Y
R
---
H
I
P
M
V
V
M
D
W
G
--
E
--
A
-
K
A
DF
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
Q
N
T
G
A
-
G
-
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
---
P
E
--
S
---
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
----
19
PsiBlast_PDB
78.58
30%
-12
- C2 -
1QQA
2
PURR_ECOLI
A:
[2-330]
--
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
A
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
---
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
-
Y
R
---
H
I
P
M
V
V
M
D
W
G
--
E
--
A
-
K
A
DF
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
T
G
A
-
G
-
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
---
P
E
--
S
---
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
----
20
PsiBlast_PDB
78.51
30%
-10
- C2 -
1QQB
2
PURR_ECOLI
A:
[2-330]
--
T
I
K
D
V
A
K
R
A
N
V
S
T
T
T
V
S
H
V
I
N
K
T
R
F
V
A
E
E
T
R
N
A
V
W
A
A
I
K
E
L
H
Y
S
P
S
A
V
A
R
S
L
A
V
N
H
T
K
S
I
G
L
L
A
T
S
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
L
I
L
G
N
A
W
N
N
L
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
V
---
M
C
S
E
Y
P
E
P
L
L
A
M
L
E
-
E
-
Y
R
---
H
I
P
M
V
V
M
D
W
G
--
E
--
A
-
K
A
DF
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
H
R
E
I
G
V
I
P
G
P
L
E
R
N
T
G
A
-
G
-
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
---
P
E
--
S
---
W
I
V
Q
G
D
F
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
Q
P
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
V
H
P
R
L
I
E
R
R
S
V
----
4
PsiBlast_PDB
78.31
31%
-17
- C2 -
3OQN
2
CCPA_BACSU
A:
[4-332]
--
T
I
Y
D
V
A
R
E
A
N
V
S
M
A
T
V
S
R
V
V
N
G
N
P
N
V
K
P
T
T
R
K
K
V
L
E
A
I
E
R
L
G
Y
R
P
N
A
V
A
R
G
L
A
S
K
K
T
T
T
V
G
V
I
I
P
D
I
S
S
I
F
Y
S
E
L
A
R
G
I
E
D
I
A
T
M
Y
K
Y
N
I
I
L
S
N
S
D
Q
N
M
E
K
E
L
H
L
L
N
T
M
L
G
K
Q
V
D
G
-
I
V
F
--
M
G
G
N
I
T
D
E
H
---
V
A
-
E
-
F
K
-
R
S
P
V
P
I
V
L
A
A
S
V
EE
Q
--
E
-
E
T
---
P
S
V
A
I
D
Y
E
Q
A
I
Y
D
A
V
K
L
L
V
D
K
G
H
T
D
I
A
F
V
S
G
P
M
A
E
P
I
N
R
-
S
K
K
L
Q
G
Y
K
R
A
L
E
E
A
--
N
L
---
P
F
N
E
Q
---
F
V
A
E
G
D
Y
T
Y
D
S
G
L
E
A
L
Q
H
L
M
S
L
D
K
K
P
T
A
I
L
S
A
T
D
E
M
A
L
G
I
I
H
A
A
Q
D
Q
G
L
S
I
P
E
D
L
D
I
I
G
F
D
N
T
R
L
S
L
M
V
R
P
Q
L
S
T
V
V
Q
P
T
Y
D
I
G
A
V
A
M
R
L
L
T
K
L
M
N
K
E
P
V
E
E
H
I
V
E
L
P
H
R
I
E
L
R
K
S
T
K
---
22
PsiBlast_CBE
78.10
31%
-14
- C2 -
3OQO
5
CCPA_BACSU
C:
[4-332]
--
T
I
Y
D
V
A
R
E
A
N
V
S
M
A
T
V
S
R
V
V
N
G
N
P
N
V
K
P
T
T
R
K
K
V
L
E
A
I
E
R
L
G
Y
R
P
N
A
V
A
R
G
L
A
S
K
K
T
T
T
V
G
V
I
I
P
D
I
S
S
I
F
Y
S
E
L
A
R
G
I
E
D
I
A
T
M
Y
K
Y
N
I
I
L
S
N
S
D
Q
N
M
E
K
E
L
H
L
L
N
T
M
L
G
K
Q
V
D
G
-
I
V
F--
M
G
G
N
I
T
D
EH---
V
A
-
E
-
F
K
-
R
S
P
V
P
I
V
L
A
A
S
V
EE
Q
--
E
-
E
T
---
P
S
V
A
I
D
Y
E
Q
A
I
Y
D
A
V
K
L
L
V
D
K
G
H
T
D
I
A
F
V
S
G
P
M
A
E
P
I
N
R
-
S
K
K
L
Q
G
Y
K
R
A
L
E
E
A
--
N
L
---
P
F
NE
Q
---
F
V
A
E
G
D
Y
T
Y
D
S
G
L
E
A
L
Q
H
L
M
S
L
D
K
K
P
T
A
I
L
S
A
T
D
E
M
A
L
G
I
I
H
A
A
Q
D
Q
G
L
S
I
P
E
D
L
D
I
I
G
F
D
N
T
R
L
S
L
M
V
R
P
Q
L
S
T
V
V
Q
P
T
Y
D
I
G
A
V
A
M
R
L
L
T
K
L
M
N
K
E
P
V
E
E
H
I
V
E
L
P
H
R
I
E
L
R
K
S
T
K
---
53
HHSearch
77.92
28%
-113
- C2 -
3JVD
3
?
A:
[64-325]
----------------------------------------------------------
S
A
L
V
G
V
I
V
P
D
L
S
N
E
Y
Y
S
E
S
L
Q
T
I
Q
Q
D
L
K
A
A
G
Y
Q
M
L
V
A
E
A
N
S
-
V
Q
A
Q
D
V
V
M
E
S
L
I
S
I
Q
A
A
G
-
I
I
---
H
V
P
V
V
G
---------
S
-
I
A
--
E
G
I
P
M
V
Q
L
T
R
------
P
-
G
F
---
P
R
V
L
C
D
D
E
A
G
F
F
Q
L
T
E
S
V
L
G
G
S
G
M
N
I
A
A
L
V
G
E
E
S
L
S
T
T
Q
-
E
-
R
M
R
G
I
S
H
A
A
S
I
Y
--
G
A
---
E
V
--
T
---
F
H
F
G
-
H
Y
S
V
E
S
G
E
E
M
A
Q
V
V
F
N
-
N
G
L
P
D
A
L
I
V
A
S
P
R
L
M
A
G
V
M
R
A
F
T
R
L
N
V
R
V
P
H
D
V
V
I
G
G
Y
D
D
P
E
W
Y
S
F
V
G
A
G
I
T
T
F
V
P
P
H
E
E
M
G
K
E
A
V
R
L
L
V
D
L
I
E
N
P
E
--
T
G
D
V
V
L
Q
G
Q
V
I
L
R
G
S
S
T
H
--
23
PsiBlast_CBE
77.88
31%
-16
- C2 -
3OQN
2
CCPA_BACSU
C:
[4-332]
--
T
I
Y
D
V
A
R
E
A
N
V
S
M
A
T
V
S
R
V
V
N
G
N
P
N
V
K
P
T
T
R
K
K
V
L
E
A
I
E
R
L
G
Y
R
P
N
A
V
A
R
G
L
A
S
K
K
T
T
T
V
G
V
I
I
P
D
I
S
S
I
F
Y
S
E
L
A
R
G
I
E
D
I
A
T
M
Y
K
Y
N
I
I
L
S
N
S
D
Q
N
M
E
K
E
L
H
L
L
N
T
M
L
G
K
Q
V
D
G
-
I
V
F--
M
G
G
N
I
T
D
EH---
V
A
-
E
-
F
K
-
R
S
P
V
P
I
V
L
A
A
S
V
EE
Q
--
E
-
E
T
---
P
S
V
A
I
D
Y
E
Q
A
I
Y
D
A
V
K
L
L
V
D
K
G
H
T
D
I
A
F
V
S
G
P
M
A
E
P
I
N
R
-
S
K
K
L
Q
G
Y
K
R
A
L
E
E
A
--
N
L
---
P
F
NE
Q
---
F
V
A
E
G
D
Y
T
Y
D
S
G
L
E
A
L
Q
H
L
M
S
L
D
K
K
P
T
A
I
L
S
A
T
D
E
M
A
L
G
I
I
H
A
A
Q
D
Q
G
L
S
I
P
E
D
L
D
I
I
G
F
D
N
T
R
L
S
L
M
V
R
P
Q
L
S
T
V
V
Q
P
T
Y
D
I
G
A
V
A
M
R
L
L
T
K
L
M
N
K
E
P
V
E
E
H
I
V
E
L
P
H
R
I
E
L
R
K
S
T
K
---
31
PsiBlast_CBE
74.32
31%
-4
- C2 -
1ZVV
6
CCPA_BACSU
B:
[3-332]
-
V
T
I
Y
D
V
A
R
E
A
S
V
S
M
A
T
V
S
R
V
V
N
G
N
P
N
V
K
P
S
T
R
K
K
V
L
E
T
I
E
R
L
G
Y
R
P
N
A
V
A
R
G
L
A
S
K
K
T
T
T
V
G
V
I
I
P
D
I
S
N
I
F
Y
A
E
L
A
R
G
I
E
D
I
A
S
M
Y
K
Y
N
I
I
L
S
N
S
D
Q
N
Q
D
K
Q
L
H
L
L
N
N
M
L
G
K
Q
V
D
G
-
I
I
FMS
G
N
V
T
E
E
H
-----
V
E
-
E
-
L
K
-
K
S
P
V
P
V
V
-
L
A
A
S
--
I
--
E
-
S
T
N
Q
I
P
S
V
T
I
D
Y
E
Q
A
A
F
D
A
V
Q
S
L
I
D
S
G
H
K
N
I
A
F
V
S
G
T
L
E
E
P
I
N
H
A
K
-
K
V
K
G
Y
K
R
A
L
T
E
S
--
G
L
PVR
D
S
--
Y
---
I
V
E
-
G
D
Y
T
Y
D
S
G
I
E
A
V
E
K
L
L
E
E
D
E
K
P
T
A
I
F
V
G
T
D
E
M
A
L
G
V
I
H
G
A
Q
D
R
G
L
N
V
P
N
D
L
E
I
I
G
F
D
N
T
R
L
S
T
M
V
R
P
Q
L
T
S
V
V
Q
P
M
Y
D
I
G
A
V
A
M
R
L
L
T
K
Y
M
N
K
E
T
V
D
S
S
I
V
E
L
P
H
R
I
E
F
R
Q
S
T
K
---
30
PsiBlast_CBE
74.21
31%
-2
- C2 -
1ZVV
3
CCPA_BACSU
G:
[3-332]
-
V
T
I
Y
D
V
A
R
E
A
S
V
S
M
A
T
V
S
R
V
V
N
G
N
P
N
V
K
P
S
T
R
K
K
V
L
E
T
I
E
---
Y
R
P
N
A
V
A
R
G
L
A
S
K
K
T
T
T
V
G
V
I
I
P
D
I
S
N
I
F
Y
A
E
L
A
R
G
I
E
D
I
A
S
M
Y
K
Y
N
I
I
L
S
N
S
D
Q
N
Q
D
K
Q
L
H
L
L
N
N
M
L
G
K
Q
V
D
G
-
I
I
FMS
G
N
V
T
E
E
H
-----
V
E
-
E
-
L
K
-
K
S
P
V
P
V
V
-
L
A
A
S
--
I
--
E
-
S
T
NQI
P
S
V
T
I
D
Y
E
Q
A
A
F
D
A
V
Q
S
L
I
D
S
G
H
K
N
I
A
F
V
S
G
T
L
E
E
P
I
N
H
A
K
-
K
V
K
G
Y
K
R
A
L
T
E
S
--
G
L
PVR
D
S
--
Y
---
I
V
E
-
G
D
Y
T
Y
D
S
G
I
E
A
V
E
K
L
L
E
E
D
E
K
P
T
A
I
F
V
G
T
D
E
M
A
L
G
V
I
H
G
A
Q
D
R
G
L
N
V
P
N
D
L
E
I
I
G
F
D
N
T
R
L
S
T
M
V
R
P
Q
L
T
S
V
V
Q
P
M
Y
D
I
G
A
V
A
M
R
L
L
T
K
Y
M
N
K
E
T
V
D
S
S
I
V
E
L
P
H
R
I
E
F
R
Q
S
T
K
---
8
PsiBlast_PDB
73.44
31%
0
- C2 -
1RZR
5
CCPA_BACME
D:
[4-332]
--
T
I
Y
D
V
A
R
E
A
S
V
S
M
A
T
V
S
R
V
V
N
G
N
P
N
V
K
P
S
T
R
K
K
V
L
E
T
I
E
R
L
G
Y
R
P
N
A
V
A
R
G
L
A
S
K
K
T
T
T
V
G
V
I
I
P
D
I
S
N
I
F
Y
A
E
L
A
R
G
I
E
D
I
A
T
M
Y
K
Y
N
I
I
L
S
N
S
D
Q
N
Q
D
K
E
L
H
L
L
N
N
M
L
G
K
Q
V
D
G
-
I
I
FMS
G
N
V
T
E
E
H
-----
V
E
-
E
-
L
K
-
K
S
P
V
P
V
V
-
L
A
A
S
--
I
--
E
-
S
T
NQI
P
S
V
T
I
D
Y
E
Q
A
A
F
D
A
V
Q
S
L
I
D
S
G
H
K
N
I
A
F
V
S
G
T
L
E
E
P
I
N
H
A
K
-
K
V
K
G
Y
K
R
A
L
T
E
S
--
G
L
PVR
D
S
--
Y
---
I
V
E
-
G
D
Y
T
Y
D
S
G
I
E
A
V
E
K
L
L
E
E
D
E
K
P
T
A
I
F
V
G
T
D
E
M
A
L
G
V
I
H
G
A
Q
D
R
G
L
N
V
P
N
D
L
E
I
I
G
F
D
N
T
R
L
S
T
M
V
R
P
Q
L
T
S
V
V
Q
P
M
Y
D
I
G
A
V
A
M
R
L
L
T
K
Y
M
N
K
E
T
V
D
S
S
I
V
Q
L
P
H
R
I
E
F
R
Q
S
T
K
---
7
PsiBlast_PDB
72.91
31%
-1
- C2 -
1ZVV
4
CCPA_BACSU
A:
[3-332]
-
V
T
I
Y
D
V
A
R
E
A
S
V
S
M
A
T
V
S
R
V
V
N
G
N
P
N
V
K
P
S
T
R
K
K
V
L
E
T
I
E
R
L
G
Y
R
P
N
A
V
A
R
G
L
A
S
K
K
T
T
T
V
G
V
I
I
P
D
I
S
N
I
F
Y
A
E
L
A
R
G
I
E
D
I
A
S
M
Y
K
Y
N
I
I
L
S
N
S
D
Q
N
Q
D
K
Q
L
H
L
L
N
N
M
L
G
K
Q
V
D
G
-
I
I
F
M
S
G
N
V
T
E
E
H
-----
V
E
-
E
-
L
K
-
K
S
P
V
P
V
V
-
L
A
A
S
--
I
--
E
-
S
T
NQ
I
P
S
V
T
I
D
Y
E
Q
A
A
F
D
A
V
Q
S
L
I
D
S
G
H
K
N
I
A
F
V
S
G
T
L
E
E
P
I
N
H
A
K
-
K
V
K
G
Y
K
R
A
L
T
E
S
--
G
L
P
V
R
D
S
--
Y
---
I
V
E
-
G
D
Y
T
Y
D
S
G
I
E
A
V
E
K
L
L
E
E
D
E
K
P
T
A
I
F
V
G
T
D
E
M
A
L
G
V
I
H
G
A
Q
D
R
G
L
N
V
P
N
D
L
E
I
I
G
F
D
N
T
R
L
S
T
M
V
R
P
Q
L
T
S
V
V
Q
P
M
Y
D
I
G
A
V
A
M
R
L
L
T
K
Y
M
N
K
E
T
V
D
S
S
I
V
E
L
P
H
R
I
E
F
R
Q
S
T
K
---