@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu36410: (2016-07-31 )
MFARDIGIDLGTANVLIHVKGKGIVLNEPSVVALDKNSGKVLAVGEEARRMVGRTPGNIVAIRPLKDGVIADFEVTEAMLKHFINKLNVKGLFSKPRMLICCPTNITSVEQKAIKEAAEKSGGKHVYLEEEPKVAAIGAGMEIFQPSGNMVVDIGGGTTDIAVISMGDIVTSSSIKMAGDKFDMEILNYIKREYKLLIGERTAEDIKIKVATVFPDARHEEISIRGRDMVSGLPRTITVNSKEVEEALRESVAVIVQAAKQVLERTPPELSADIIDRGVIITGGGALLNGLDQLLAEELKVPVLVAENPMDCVAIGTGVMLDNMDKLPKRKLS
Atome Classification :
(20 SA)
.........10.....-...20.-.-...------....30......-----..--40-.........50........60.--------------------....-----.------------------.-------------.70--.------........80........90--......-...100.......110.......120........130.......140.---.-------.....150.......160....--...--170--.-.--.......180.......190....---..-------------.-------------200.......210.......220---------.--..--.....230.......240..---.....250-----........260.......270.......280.......290.......300..--------------------......310.......320.......330.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MF
A
R
DIGIDLGT
A
N
V
L
-
I
H
V
K-G-
K
-
G
I
V
------LNEP
S
V
V
A
L
DKN-----S
G
--
K
--
V
L
A
V
G
E
E
A
R
R
M
VGRTPG
N
I
V
A
I
--------------------
R
PLK-----D------------------G-------------VI---A------
D
F
E
V
T
E
A
M
L
K
H
F
I
N
KLNVK---GLFSKP-
R
M
L
I
CCPTNI
T
S
V
E
Q
K
A
I
K
E
A
A
E
K-SGG
K
H
V
Y
LEEEP
K
V
A
A
IGAG
M
E
I
---F-------QPSG
N
M
V
V
D
IGGG
T
T
D
I
A
V
I
S
M--G
D
I
--V----T-S--SSIKMAGDKF
D
M
E
I
L
N
Y
I
K
R
E
Y
K
L
---
L
I-------------G-------------ERTAE
D
I
K
I
K
V
A
T
VFPDARH
E
E
----------
I
--
S
I
--RG
R
D
M
VSGLP
R
T
I
T
V
N
S
K
E
V
---
E
E
A
L
R
E
S
------
V
A
V
I
V
Q
A
A
K
Q
V
L
E
RTPPE
L
S
A
D
I
IDR
G
V
I
I
TG
G
G
A
L
L
N
G
L
D
Q
L
L
A
E
ELK-V
P
V
--------------------
L
V
AENPM
D
C
V
A
IGT
G
V
M
LD
N
M
D
KLPKRKLS
3
PsiBlast_PDB
97.03
51%
-44
- C1 -
2WUS
-
?
A:
[2-331]
-
L
R
K
D
I
G
I
D
L
G
T
A
N
T
L
-
V
F
L
R
-
G
-
K
-
G
I
V
------
V
N
E
P
S
V
I
A
I
D
S
T
-----
T
G
--
E
--
I
L
K
V
G
L
E
A
K
N
M
I
G
K
T
P
A
T
I
K
A
I
--------------------
R
P
M
R
-----
D
------------------
G
-------------
V
I
---
A
------
D
Y
T
V
A
L
V
M
L
R
Y
F
I
N
K
A
K
G
G
---
M
N
L
F
K
P
-
R
V
V
I
G
V
P
I
G
I
T
D
V
E
R
R
A
I
L
D
A
G
L
E
-
A
G
A
S
K
V
F
L
I
E
E
P
M
A
A
A
I
G
S
N
L
N
V
---
E
-------
E
P
S
G
N
M
V
V
D
I
G
G
G
T
T
E
V
A
V
I
S
L
--
G
S
I
--
V
----
T
-
W
--
E
S
I
R
I
A
G
D
E
M
D
E
A
I
V
Q
Y
V
R
E
T
Y
R
V
---
A
I
-------------
G
-------------
E
R
T
A
E
R
V
K
I
E
I
G
N
V
F
P
S
K
E
N
D
E
----------
L
E
T
T
V
--
S
G
I
D
L
S
T
G
L
P
R
K
L
T
L
K
G
G
E
V
---
R
E
A
L
R
S
V
------
V
V
A
I
V
E
S
V
R
T
T
L
E
K
T
P
P
E
L
V
S
D
I
I
E
R
G
I
F
L
T
G
G
G
S
L
L
R
G
L
D
T
L
L
Q
K
E
T
G
-
I
S
V
--------------------
I
R
S
E
E
P
L
T
A
V
A
K
G
A
G
M
V
L
D
K
V
N
I
L
K
K
----
2
PsiBlast_PDB
94.58
51%
-36
- C1 -
1JCG
2
?
A:
[1-331]
M
L
R
K
D
I
G
I
D
L
G
T
A
N
T
L
-
V
F
L
R
-
G
-
K
-
G
I
V
------
V
N
E
P
S
V
I
A
I
D
S
T
-----
T
G
--
E
--
I
L
K
V
G
L
E
A
K
N
M
I
G
K
T
P
A
T
I
K
A
I
--------------------
R
P
M
R
-----
D
------------------
G
-------------
V
I
---
A
------
D
Y
T
V
A
L
V
M
L
R
Y
F
I
N
K
A
K
G
G
---
M
N
L
F
K
P
-
R
V
V
I
G
V
P
I
G
I
T
D
V
E
R
R
A
I
L
D
A
G
L
E
-
A
G
A
S
K
V
F
L
I
E
E
P
M
A
A
A
I
G
S
N
L
N
V
---
E
-------
E
P
S
G
N
M
V
V
D
I
G
G
G
T
T
E
V
A
V
I
S
L
--
G
S
I
--
V
----
T
-
W
--
E
S
I
R
I
A
G
D
E
M
D
E
A
I
V
Q
Y
V
R
E
T
Y
R
V
---
A
I
-------------
G
-------------
E
R
T
A
E
R
V
K
I
E
I
G
N
V
F
P
S
K
E
N
D
E
----------
L
E
T
T
V
--
S
G
I
D
L
S
T
G
L
P
R
K
L
T
L
K
G
G
E
V
---
R
E
A
L
R
S
V
------
V
V
A
I
V
E
S
V
R
T
T
L
E
K
T
P
P
E
L
V
S
D
I
I
E
R
G
I
F
L
T
G
G
G
S
L
L
R
G
L
D
T
L
L
Q
K
E
T
G
-
I
S
V
--------------------
I
R
S
E
E
P
L
T
A
V
A
K
G
A
G
M
V
L
D
K
V
N
I
L
K
K
----
1
PsiBlast_PDB
94.40
51%
-36
- C1 -
1JCF
-
?
A:
[1-331]
M
L
R
K
D
I
G
I
D
L
G
T
A
N
T
L
-
V
F
L
R
-
G
-
K
-
G
I
V
------
V
N
E
P
S
V
I
A
I
D
S
T
-----
T
G
--
E
--
I
L
K
V
G
L
E
A
K
N
M
I
G
K
T
P
A
T
I
K
A
I
--------------------
R
P
M
R
-----
D
------------------
G
-------------
V
I
---
A
------
D
Y
T
V
A
L
V
M
L
R
Y
F
I
N
K
A
K
G
G
---
M
N
L
F
K
P
-
R
V
V
I
G
V
P
I
G
I
T
D
V
E
R
R
A
I
L
D
A
G
L
E
-
A
G
A
S
K
V
F
L
I
E
E
P
M
A
A
A
I
G
S
N
L
N
V
---
E
-------
E
P
S
G
N
M
V
V
D
I
G
G
G
T
T
E
V
A
V
I
S
L
--
G
S
I
--
V
----
T
-
W
--
E
S
I
R
I
A
G
D
E
M
D
E
A
I
V
Q
Y
V
R
E
T
Y
R
V
---
A
I
-------------
G
-------------
E
R
T
A
E
R
V
K
I
E
I
G
N
V
F
P
S
K
E
N
D
E
----------
L
E
T
T
V
--
S
G
I
D
L
S
T
G
L
P
R
K
L
T
L
K
G
G
E
V
---
R
E
A
L
R
S
V
------
V
V
A
I
V
E
S
V
R
T
T
L
E
K
T
P
P
E
L
V
S
D
I
I
E
R
G
I
F
L
T
G
G
G
S
L
L
R
G
L
D
T
L
L
Q
K
E
T
G
-
I
S
V
--------------------
I
R
S
E
E
P
L
T
A
V
A
K
G
A
G
M
V
L
D
K
V
N
I
L
K
K
----
4
PsiBlast_PDB
94.19
50%
-34
- C1 -
1JCE
-
?
A:
[4-331]
---
K
D
I
G
I
D
L
G
T
A
N
T
L
-
V
F
L
R
-
G
-
K
-
G
I
V
------
V
N
E
P
S
V
I
A
I
D
S
T
-----
T
G
--
E
--
I
L
K
V
G
L
E
A
K
N
M
I
G
K
T
P
A
T
I
K
A
I
--------------------
R
P
M
R
-----
D
------------------
G
-------------
V
I
---
A
------
D
Y
T
V
A
L
V
M
L
R
Y
F
I
N
K
A
K
G
G
---
M
N
L
F
K
P
-
R
V
V
I
G
V
P
I
G
I
T
D
V
E
R
R
A
I
L
D
A
G
L
E
-
A
G
A
S
K
V
F
L
I
E
E
P
M
A
A
A
I
G
S
N
L
N
V
---
E
-------
E
P
S
G
N
M
V
V
D
I
G
G
G
T
T
E
V
A
V
I
S
L
--
G
S
I
--
V
----
T
-
W
--
E
S
I
R
I
A
G
D
E
M
D
E
A
I
V
Q
Y
V
R
E
T
Y
R
V
---
A
I
-------------
G
-------------
E
R
T
A
E
R
V
K
I
E
I
G
N
V
F
P
S
K
E
N
D
E
----------
L
E
T
T
V
--
S
G
I
D
L
S
T
G
L
P
R
K
L
T
L
K
G
G
E
V
---
R
E
A
L
R
S
V
------
V
V
A
I
V
E
S
V
R
T
T
L
E
K
T
P
P
E
L
V
S
D
I
I
E
R
G
I
F
L
T
G
G
G
S
L
L
R
G
L
D
T
L
L
Q
K
E
T
G
-
I
S
V
--------------------
I
R
S
E
E
P
L
T
A
V
A
K
G
A
G
M
V
L
D
K
V
N
I
L
K
K
----
21
PsiBlast_CBE
87.59
51%
-2
- C1 -
4CZJ
2
?
B:
[5-327]
----
D
I
A
I
D
L
G
T
A
N
T
L
-
I
Y
Q
K
-
G
-
K
-
G
I
V
------
L
N
E
P
S
V
V
A
L
R
N
V
-----
G
G
--
R
KV
V
H
A
V
G
I
E
A
K
Q
M
L
G
R
T
P
G
H
M
E
A
I
--------------------
R
P
M
R
-----
D
------------------
G
-------------
V
I
---
A
------
D
F
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
---------
P
-
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
L
N
-
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
---
H
-------
E
P
T
G
S
M
V
V
D
I
G
G
G
T
T
E
V
A
V
L
S
L
--
S
G
I
--
V
----
Y
-
S
--
R
S
V
R
V
G
G
D
K
M
D
E
A
I
I
S
Y
M
R
R
H
H
N
L
---
L
I
-------------
G
-------------
E
T
T
A
E
R
I
K
K
E
I
G
T
A
R
A
P
A
D
G
E
G
----------
L
--
S
I
D
V
K
G
R
D
L
M
Q
G
V
P
R
E
V
R
I
S
E
K
Q
A
---
A
D
A
L
A
E
P
------
V
G
Q
I
V
E
A
V
K
V
A
L
E
A
T
P
P
E
L
A
S
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
-
L
P
V
--------------------
T
V
A
D
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
H
----------
7
PsiBlast_PDB
87.50
51%
1
- C1 -
4CZG
3
?
A:
[2-327]
-
I
S
N
D
I
A
I
D
L
G
T
A
N
T
L
-
I
Y
Q
K
-
G
-
K
-
G
I
V
------
L
N
E
P
S
V
V
A
L
R
N
V
-----
G
G
--
R
KV
V
H
A
V
G
I
E
A
K
Q
M
L
G
R
T
P
G
H
M
E
A
I
--------------------
R
P
M
R
-----
D
------------------
G
-------------
V
I
---
A
------
D
F
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
R
---
K
G
S
G
N
P
-
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
L
N
-
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
---
H
-------
E
P
T
G
S
M
V
V
D
I
G
G
G
T
T
E
V
A
V
L
S
L
--
S
G
I
--
V
----
Y
-
S
--
R
S
V
R
V
G
G
D
K
M
D
E
A
I
I
S
Y
M
R
R
H
H
N
L
---
L
I
-------------
G
-------------
E
T
T
A
E
R
I
K
K
E
I
G
T
A
R
A
P
----
G
----------
L
--
S
I
D
V
K
G
R
D
L
M
Q
G
V
P
R
E
V
R
I
S
E
K
Q
A
---
A
D
A
L
A
E
P
------
V
G
Q
I
V
E
A
V
K
V
A
L
E
A
T
P
P
E
L
A
S
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
-
L
P
V
--------------------
T
V
A
D
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
H
----------
8
PsiBlast_PDB
87.10
51%
4
- C1 -
4CZH
3
?
A:
[2-327]
-
I
S
N
D
I
A
I
D
L
G
T
A
N
T
L
-
I
Y
Q
K
-
G
-
K
-
G
I
V
------
L
N
E
P
S
V
V
A
L
R
N
V
-----
G
G
--
R
KV
V
H
A
V
G
I
E
A
K
Q
M
L
G
R
T
P
G
H
M
E
A
I
--------------------
R
P
M
R
-----
D
------------------
G
-------------
V
I
---
A
------
D
F
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
R
---
K
G
S
G
N
P
-
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
L
N
-
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
---
H
-------
E
P
T
G
S
M
V
V
D
I
G
G
G
T
T
E
V
A
V
L
S
L
--
S
G
I
--
V
----
Y
-
S
--
R
S
V
R
V
G
G
D
K
M
D
E
A
I
I
S
Y
M
R
R
H
H
N
L
---
L
I
-------------
G
-------------
E
T
T
A
E
R
I
K
K
E
I
G
T
A
R
A
P
----
G
----------
L
--
S
I
D
V
K
G
R
D
L
M
Q
G
V
P
R
E
V
R
I
S
E
K
Q
A
---
A
D
A
L
A
E
P
------
V
G
Q
I
V
E
A
V
K
V
A
L
E
A
T
P
P
E
L
A
S
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
-
L
P
V
--------------------
T
V
A
D
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
H
----------
10
PsiBlast_PDB
86.28
51%
-4
- C1 -
4CZJ
2
?
A:
[5-327]
----
D
I
A
I
D
L
G
T
A
N
T
L
-
I
Y
Q
K
-
G
-
K
-
G
I
V
------
L
N
E
P
S
V
V
A
L
R
N
V
-----
G
G
--
R
KV
V
H
A
V
G
I
E
A
K
Q
M
L
G
R
T
P
G
H
M
E
A
I
--------------------
R
P
M
R
-----
D
------------------
G
-------------
V
I
---
A
------
D
F
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
---------
P
-
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
L
N
-
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
---
H
-------
E
P
T
G
S
M
V
V
D
I
G
G
G
T
T
E
V
A
V
L
S
L
--
S
G
I
--
V
----
Y
-
S
--
R
S
V
R
V
G
G
D
K
M
D
E
A
I
I
S
Y
M
R
R
H
H
N
L
---
L
I
-------------
G
-------------
E
T
T
A
E
R
I
K
K
E
I
G
T
A
R
A
P
---
E
G
----------
L
--
S
I
D
V
K
G
R
D
L
M
Q
G
V
P
R
E
V
R
I
S
E
K
Q
A
---
A
D
A
L
A
E
P
------
V
G
Q
I
V
E
A
V
K
V
A
L
E
A
T
P
P
E
L
A
S
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
-
L
P
V
--------------------
T
V
A
D
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
H
----------
6
PsiBlast_PDB
86.20
51%
0
- C1 -
4CZF
2
?
A:
[2-327]
-
I
S
N
D
I
A
I
D
L
G
T
A
N
T
L
-
I
Y
Q
K
-
G
-
K
-
G
I
V
------
L
N
E
P
S
V
V
A
L
R
N
-----------KV
V
H
A
V
G
I
E
A
K
Q
M
L
G
R
T
P
G
H
M
E
A
I
--------------------
R
P
M
R
-----
D
------------------
G
-------------
V
I
---
A
------
D
F
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
R
---
K
G
S
G
N
P
-
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
L
N
-
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
---
H
-------
E
P
T
G
S
M
V
V
D
I
G
G
G
T
T
E
V
A
V
L
S
L
--
S
G
I
--
V
----
Y
-
S
--
R
S
V
R
V
G
G
D
K
M
D
E
A
I
I
S
Y
M
R
R
H
H
N
L
---
L
I
-------------
G
-------------
E
T
T
A
E
R
I
K
K
E
I
G
T
A
R
A
P
----
G
----------
L
--
S
I
D
V
K
G
R
D
L
M
Q
G
V
P
R
E
V
R
I
S
E
K
Q
A
---
A
D
A
L
A
E
P
------
V
G
Q
I
V
E
A
V
K
V
A
L
E
A
T
P
P
E
L
A
S
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
-
L
P
V
--------------------
T
V
A
D
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
H
----------
23
HHSearch
85.53
50%
-3
- C1 -
1JCE
-
?
A:
[4-333]
---
K
D
I
G
I
D
L
G
T
A
N
T
L
V
F
L
R
G
-
K
---
G
I
V
------
V
N
E
P
S
V
I
A
I
D
S
T
-----
T
G
--
E
--
I
L
K
V
G
L
E
A
K
N
M
I
G
K
T
P
A
T
I
K
A
I
--------------------
R
P
M
R
-----
D
------------------
G
-------------
V
I
---
A
------
D
Y
T
V
A
L
V
M
L
R
Y
F
I
N
K
A
K
G
G
----
M
N
L
F
K
P
R
V
V
I
G
V
P
I
G
I
T
D
V
E
R
R
A
I
L
D
A
G
L
E
-
A
G
A
S
K
V
F
L
I
E
E
P
M
A
A
A
I
G
S
N
L
N
V
---
E
-------
E
P
S
G
N
M
V
V
D
I
G
G
G
T
T
E
V
A
V
I
S
L
--
G
S
I
--
V
----
T
-
W
--
E
S
I
R
I
A
G
D
E
M
D
E
A
I
V
Q
Y
V
R
E
T
Y
R
V
---
A
I
-------------
G
-------------
E
R
T
A
E
R
V
K
I
E
I
G
N
V
F
P
S
K
E
N
D
E
----------
L
E
T
T
V
--
S
G
I
D
L
S
T
G
L
P
R
K
L
T
L
K
G
G
E
V
---
R
E
A
L
R
S
V
------
V
V
A
I
V
E
S
V
R
T
T
L
E
K
T
P
P
E
L
V
S
D
I
I
E
R
G
I
F
L
T
G
G
G
S
L
L
R
G
L
D
T
L
L
Q
K
E
T
G
-
I
S
V
--------------------
I
R
S
E
E
P
L
T
A
V
A
K
G
A
G
M
V
L
D
K
V
N
I
L
K
K
L
Q
--
13
PsiBlast_PDB
85.53
51%
1
- C1 -
4CZM
2
?
A:
[2-327]
-
I
S
N
D
I
A
I
D
L
G
T
A
N
T
L
-
I
Y
Q
K
-
G
-
K
-
G
I
V
------
L
N
E
P
S
V
V
A
L
R
N
V
-----
G
G
--
R
K
V
V
H
A
V
G
I
E
A
K
Q
M
L
G
R
T
P
G
H
M
E
A
I
--------------------
R
P
M
R
-----
D
------------------
G
-------------
V
I
---
A
------
D
F
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
R
---
K
G
S
G
N
P
-
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
L
N
-
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
---
H
-------
E
P
T
G
S
M
V
V
D
I
G
G
G
T
T
E
V
A
V
L
S
L
--
S
G
I
--
V
----
Y
-
S
--
R
S
V
R
V
G
G
D
K
M
D
E
A
I
I
S
Y
M
R
R
H
H
N
L
---
L
I
-------------
G
-------------
E
T
T
A
E
R
I
K
K
E
I
G
T
A
R
A
P
A
D
G
E
G
----------
L
--
S
I
D
V
K
G
R
D
L
M
Q
G
V
P
R
E
V
R
I
S
E
K
Q
A
---
A
D
A
L
A
E
P
------
V
G
Q
I
V
E
A
V
K
V
A
L
E
A
T
P
P
E
L
A
D
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
-
L
P
V
--------------------
T
V
A
D
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
H
----------
5
PsiBlast_PDB
85.29
51%
-1
- C1 -
4CZE
1
?
A:
[3-326]
--
S
N
D
I
A
I
D
L
G
T
A
N
T
L
-
I
Y
Q
K
-
G
-
K
-
G
I
V
------
L
N
E
P
S
V
V
A
L
R
N
V
-----
G
G
--
R
KV
V
H
A
V
G
I
E
A
K
Q
M
L
G
R
T
P
G
H
M
E
A
I
--------------------
R
P
M
R
-----
D
------------------
G
-------------
V
I
---
A
------
D
F
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
R
---
K
G
F
V
N
P
-
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
L
N
-
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
---
H
-------
E
P
T
G
S
M
V
V
D
I
G
G
G
T
T
E
V
A
V
L
S
L
--
S
G
I
--
V
----
Y
-
S
--
R
S
V
R
V
G
G
D
K
M
D
E
A
I
I
S
Y
M
R
R
H
H
N
L
---
L
I
-------------
G
-------------
E
T
T
A
E
R
I
K
K
E
I
G
T
A
R
A
P
---
E
G
----------
L
--
S
I
D
V
K
G
R
D
L
M
Q
G
V
P
R
E
V
R
I
S
E
K
Q
A
---
A
D
A
L
A
E
P
------
V
G
Q
I
V
E
A
V
K
V
A
L
E
A
T
P
P
E
L
A
S
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
-
L
P
V
--------------------
T
V
A
D
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
-----------
11
PsiBlast_PDB
85.01
51%
1
- C1 -
4CZK
3
?
A:
[2-327]
-
I
S
N
D
I
A
I
D
L
G
T
A
N
T
L
-
I
Y
Q
K
-
G
-
K
-
G
I
V
------
L
N
E
P
S
V
V
A
L
R
N
-----------KV
V
H
A
V
G
I
E
A
K
Q
M
L
G
R
T
P
G
H
M
E
A
I
--------------------
R
P
M
R
-----
D
------------------
G
-------------
V
I
---
A
------
D
F
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
R
---
K
G
S
G
N
P
-
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
L
N
-
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
---
H
-------
E
P
T
G
S
M
V
V
D
I
G
G
G
T
T
E
V
A
V
L
S
L
--
S
G
I
--
V
----
Y
-
S
--
R
S
V
R
V
G
G
D
K
M
D
E
A
I
I
S
Y
M
R
R
H
H
N
L
---
L
I
-------------
G
-------------
E
T
T
A
E
R
I
K
K
E
I
G
T
A
R
A
P
----
G
----------
L
--
S
I
D
V
K
G
R
D
L
M
Q
G
V
P
R
E
V
R
I
S
E
K
Q
A
---
A
D
A
L
A
E
P
------
V
G
Q
I
V
E
A
V
K
V
A
L
E
A
T
P
P
E
L
A
S
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
-
L
P
V
--------------------
T
V
A
D
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
H
----------
12
PsiBlast_PDB
84.62
51%
-1
- C1 -
4CZL
2
?
A:
[2-327]
-
I
S
N
D
I
A
I
D
L
G
T
A
N
T
L
-
I
Y
Q
K
-
G
-
K
-
G
I
V
------
L
N
E
P
S
V
V
A
L
R
N
V
-----
G
G
--
R
KV
V
H
A
V
G
I
E
A
K
Q
M
L
------
M
E
A
I
--------------------
R
P
M
R
-----
D
------------------
G
-------------
V
I
---
A
------
D
F
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
R
---
K
G
S
G
N
P
-
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
L
N
-
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
---
H
-------
E
P
T
G
S
M
V
V
D
I
G
G
G
T
T
E
V
A
V
L
S
L
--
S
G
I
--
V
----
Y
-
S
--
R
S
V
R
V
G
G
D
K
M
D
E
A
I
I
S
Y
M
R
R
H
H
N
L
---
L
I
-------------
G
-------------
E
T
T
A
E
R
I
K
K
E
I
G
T
A
R
A
P
A
D
G
E
G
----------
L
--
S
I
D
V
K
G
R
D
L
M
Q
G
V
P
R
E
V
R
I
S
E
K
Q
A
---
A
D
A
L
A
E
P
------
V
G
Q
I
V
E
A
V
K
V
A
L
E
A
T
P
P
E
L
A
D
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
-
L
P
V
--------------------
T
V
A
D
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
H
----------
9
PsiBlast_PDB
84.59
51%
1
- C1 -
4CZI
-
?
A:
[9-334]
-
I
S
N
D
I
A
I
D
L
G
T
A
N
T
L
-
I
Y
Q
K
-
G
-
K
-
G
I
V
------
L
N
E
P
S
V
V
A
L
R
N
-----------KV
V
H
A
V
G
I
E
A
K
Q
M
L
G
R
T
P
G
H
M
E
A
I
--------------------
R
P
M
R
-----
D
------------------
G
-------------
V
I
---
A
------
D
F
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
R
---
K
G
S
G
N
P
-
K
V
I
V
C
V
P
S
--
T
A
V
E
R
R
A
I
N
D
S
C
L
N
-
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
---
H
-------
E
P
T
G
S
M
V
V
D
I
G
G
G
T
T
E
V
A
V
L
S
L
--
S
G
I
--
V
----
Y
-
S
--
R
S
V
R
V
G
G
D
K
M
D
E
A
I
I
S
Y
M
R
R
H
H
N
L
---
L
I
-------------
G
-------------
E
T
T
A
E
R
I
K
K
E
I
G
T
A
R
A
P
----
G
----------
L
--
S
I
D
V
K
G
R
D
L
M
Q
G
V
P
R
E
V
R
I
S
E
K
Q
A
---
A
D
A
L
A
E
P
------
V
G
Q
I
V
E
A
V
K
V
A
L
E
A
T
P
P
E
L
A
S
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
-
L
P
V
--------------------
T
V
A
D
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
H
----------
22
PsiBlast_CBE
83.25
51%
2
- C1 -
4CZM
2
?
B:
[2-327]
-
I
S
N
D
I
A
I
D
L
G
T
A
N
T
L
-
I
Y
Q
K
-
G
-
K
-
G
I
V
------
L
N
E
P
S
V
V
A
L
R
N
V
-----
G
G
--
R
KV
V
H
A
V
G
I
E
A
K
Q
M
L
G
R
T
P
G
H
M
E
A
I
--------------------
R
P
M
R
-----
D
------------------
G
-------------
V
I
---
A
------
D
F
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
R
---
K
G
S
G
N
P
-
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
L
N
-
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
---
H
-------
E
P
T
G
S
M
V
V
D
I
G
G
G
T
T
E
V
A
V
L
S
L
--
S
G
I
--
V
----
Y
-
S
--
R
S
V
R
V
G
G
D
K
M
D
E
A
I
I
S
Y
M
R
R
H
H
N
L
---
L
I
-------------
G
-------------
E
T
T
A
E
R
I
K
K
E
I
G
T
A
R
A
P
A
D
G
E
G
----------
L
--
S
I
DV
K
G
R
D
L
M
Q
G
V
P
R
E
V
R
I
S
E
K
Q
A
---
A
D
A
L
A
E
P
------
V
G
Q
I
V
E
A
V
K
V
A
L
E
A
T
P
P
E
L
A
D
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
-
L
P
V
--------------------
T
V
A
D
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
H
----------
24
HHSearch
83.18
50%
14
- C1 -
4CZG
3
?
A:
[2-327]
-
I
S
N
D
I
A
I
D
L
G
T
A
N
T
L
I
Y
Q
K
G
-
K
---
G
I
V
------
L
N
E
P
S
V
V
A
L
R
N
V
-----
G
G
RK
V
--
V
H
A
V
G
I
E
A
K
Q
M
L
G
R
T
P
G
H
M
E
A
I
--------------------
R
P
M
R
-----
D
------------------
G
-------------
V
I
---
A
------
D
F
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
R
----
K
G
S
G
N
P
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
L
N
-
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
---
H
-------
E
P
T
G
S
M
V
V
D
I
G
G
G
T
T
E
V
A
V
L
S
L
--
S
G
I
--
V
----
Y
-
S
--
R
S
V
R
V
G
G
D
K
M
D
E
A
I
I
S
Y
M
R
R
H
H
N
L
---
L
I
-------------
G
-------------
E
T
T
A
E
R
I
K
K
E
I
G
T
A
R
A
P
----
G
----------
L
S
I
D
V
--
K
G
R
D
L
M
Q
G
V
P
R
E
V
R
I
S
E
K
Q
A
---
A
D
A
L
A
E
P
------
V
G
Q
I
V
E
A
V
K
V
A
L
E
A
T
P
P
E
L
A
S
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
-
L
P
V
--------------------
T
V
A
D
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
H
----------
43
HHSearch
50.10
18%
-1
- C1 -
1K8K
-
ARP3_BOVIN
A:
[5-387]
--
L
P
A
C
V
V
D
C
G
T
G
Y
T
K
L
G
Y
A
G
-
N
-
T
-
E
P
Q
------
F
I
I
P
S
C
I
A
I
K
E
-VMKGV
D
D
--
L
--
D
F
F
I
G
D
E
A
I
E
K
P
-----
T
Y
A
T
K
--------------------
W
P
I
R
-----
H
------------------
G
-------------
I
V
---
E
------
D
W
D
L
M
E
R
F
M
E
Q
V
I
F
K
Y
L
R
A
-----
E
P
E
D
H
Y
F
L
L
T
E
P
P
L
N
T
P
E
N
R
E
Y
T
A
E
I
M
F
E
S
F
N
V
P
G
L
Y
I
A
V
Q
A
V
L
A
L
A
A
S
W
T
S
R
QVG
E
-------
R
T
L
T
G
T
V
I
D
S
G
D
G
V
T
H
V
I
P
V
A
E
--
G
Y
V
--
I
----
G
-
S
C
I
K
H
I
P
I
A
G
R
D
I
T
Y
F
I
Q
Q
L
L
R
D
R
E
V
G
IPP
E
Q
-------------
S
-------------
L
E
T
A
K
A
V
K
E
R
Y
S
Y
V
C
P
D
L
V
K
E
F
N
K
Y
D
T
DGSKW
I
K
-
Q
Y
--
T
G
I
N
A
I
S
K
K
E
F
S
I
D
V
G
Y
E
R
F
LGP
E
I
F
F
H
P
E
FANPDF
T
Q
P
I
S
E
V
V
D
E
V
I
Q
N
C
P
I
D
V
R
R
P
-
L
Y
K
N
I
V
L
S
G
G
S
T
M
F
R
D
F
G
R
R
L
Q
R
D
L
K
-
R
T
V
D
A
R
L
K
L
S
E
E
L
SKPK
P
I
D
V
Q
V
I
T
H
H
M
Q
R
Y
A
V
W
F
G
G
S
M
L
A
S
T
----------
28
HHSearch
49.29
21%
0
- C- -
4FL9
3
HSP7C_BOVIN
A:
[4-391]
--
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
-
H
G
K
V
E
I
I
A
N
DQGN
R
T
T
P
S
Y
V
A
F
T
D
----------
T
--
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
AKRLIG--------------
R
R
F
D
-----
D
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
A
G
R
P
K
V
Q
V
E
Y
KG
E
T
K
S
F
---
Y
------
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
----
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
-
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
---
K
VG-----
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
--
A
A
G
--
I
F
E
V
K
S
T
A
--
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
---
K
H
KKDISEN
K
R
A
V
R
R
L
-------------
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
------------------
S
I
--
E
I
D
S
L
Y
E
G
I
D
F
Y
T
S
I
T
R
A
R
F
---
E
E
L
N
A
D
L
------
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
--
K
-
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
K
E
L
--------------------
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
---------
25
HHSearch
49.21
20%
20
- C1 -
3D2F
4
?
A:
[2-390]
--
S
T
P
F
G
L
D
L
G
N
N
N
S
V
L
A
V
A
R
N
R
-
G
I
D
I
V
V
N
EVSN
R
S
T
P
S
V
V
G
F
G
P
----------
K
--
N
R
Y
L
G
E
T
G
K
N
K
Q
T
S
N
I
K
N
T
V
A
N
LKRIIGLDYHHPD
F
E
Q
E
S
K
H
F
T
S
K
L
V
E
L
D
D
------------------
K
-------------
K
T
G
A
E
V
R
F
AG
E
K
H
V
F
S
A
T
Q
L
A
A
M
F
I
D
K
V
K
D
T
V
K
Q
D
T
K
A
N
I
T
D
V
C
I
A
V
P
P
W
Y
T
E
E
Q
R
Y
N
I
A
D
A
A
R
I
-
A
G
L
N
P
V
R
I
V
N
D
V
T
A
A
G
V
S
Y
G
I
F
K
---
T
DLPEGEE
K
P
R
I
V
A
F
V
D
I
G
H
S
S
Y
T
C
S
I
M
A
F
K
K
G
Q
L
K
V
L
----
G
T
A
--
C
D
K
H
F
G
G
R
D
F
D
L
A
I
T
E
H
F
A
D
E
F
K
T
---
K
Y
-------------
K
IDIREN
P
K
A
Y
N
R
I
L
T
A
A
E
K
L
K
K
V
L
S
A
N
T
N
A
------------------
P
F
--
S
V
E
S
V
M
N
D
V
D
V
S
S
Q
L
S
R
E
E
L
---
E
E
L
V
K
P
L
------
L
E
R
V
T
E
P
V
T
K
A
L
A
Q
A
K
L
S
--
A
-
E
E
V
D
F
V
E
I
I
G
G
T
T
R
I
P
T
L
K
Q
S
I
S
E
A
F
G
-
K
P
L
--------------------
S
T
T
L
N
Q
D
E
A
I
A
K
G
A
A
F
I
C
A
I
H
S
--------