@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu37060: (2016-08-01 )
MYIMKQSGWLELICGSMFSGKSEELIRRVKRATYAKQEVRVFKPVIDNRYSEAAVVSHNGTSMTSYAISSAADIWDHISESTDVVAVDEVQFFDQEIVEVLSSLADKGYRVIAAGLDMDFRGEPFGVVPNIMAIAESVTKLQAVCSVCGSPASRTQRLIDGKPASYDDPVILVGAAESYEARCRHHHEVPGKSKK
Atome Classification :
(44 SA)
.........10........20........30........40........50........60......----.-.70.....-----..-----.80........90........100.......110.......120.......130.......140.......-150-........160.......170.......180.......190...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
Y
I
MKQSG
W
L
E
L
I
C
G
SMFSG
K
S
E
E
L
I
R
R
V
K
R
A
T
Y
A
K
Q
E
V
R
V
F
K
P
V
IDNRYS
E
A
A
V
V
SHNGTS
M
T
S
Y
A----I-
S
S
A
A
D
I
W
D
-----
H
I-----SEST
D
V
V
A
V
D
E
V
Q
F
F
D
Q
E
I
V
E
V
L
S
S
L
A
DKG
Y
R
V
I
A
AGLDMDFRGEPFGVV
P
N
I
M
A
I
A
E
S
V
T
K
L
Q
A
V
C
S
V
CG-S-
P
-
A
S
R
T
Q
R
LIDGKPASYDD
P
V
I
L
V
GAA
E
S
Y
E
A
R
C
R
H
HHEVPGKSKK
1
PsiBlast_PDB
91.66
69%
-108
- C10 -
2JA1
3
KITH_BACCR
A:
[3-193]
M
Y
L
I
N
Q
N
G
W
I
E
V
I
C
G
S
M
F
S
G
K
S
E
E
L
I
R
R
V
R
R
T
Q
F
A
K
Q
H
A
I
V
F
K
P
C
I
D
N
R
Y
S
E
E
D
V
V
S
H
N
G
L
K
V
K
A
V
P
----
V
-
S
A
S
K
D
I
F
E
-----
H
I
-----
T
E
E
L
D
V
I
A
I
D
E
V
Q
F
F
D
G
D
I
V
E
V
V
Q
V
L
A
N
R
G
Y
R
V
I
V
A
G
L
D
Q
D
F
R
G
L
P
F
G
Q
V
P
Q
L
M
A
I
A
E
H
V
T
K
L
Q
A
V
C
S
V
C
G
-
S
-
P
-
A
S
R
T
Q
R
L
I
D
G
E
P
A
A
F
D
D
P
I
I
L
V
G
A
S
E
S
Y
E
P
R
C
R
H
C
H
A
V
P
A
----
2
PsiBlast_PDB
84.47
69%
-119
- C10 -
2J9R
3
KITH_BACAN
A:
[21-213]
M
Y
L
I
N
Q
N
G
W
I
E
V
I
C
G
S
M
F
S
G
K
S
E
E
L
I
R
R
V
R
R
T
Q
F
A
K
Q
H
A
I
V
F
K
P
C
-----------------
V
K
A
V
P
----
V
-
S
A
S
K
D
I
F
K
-----
H
I
-----
T
E
E
M
D
V
I
A
I
D
E
V
Q
F
F
D
G
D
I
V
E
V
V
Q
V
L
A
N
R
G
Y
R
V
I
V
A
G
L
D
Q
D
F
R
G
L
P
F
G
Q
V
P
Q
L
M
A
I
A
E
H
V
T
K
L
Q
A
V
C
S
A
C
G
-
S
-
P
-
A
S
R
T
Q
R
L
I
D
G
E
P
A
A
F
D
D
P
I
I
L
V
G
A
S
E
S
Y
E
P
R
C
R
H
C
H
A
V
P
T
K
Q
--
78
HHSearch
83.95
70%
-122
- C10 -
2J9R
3
KITH_BACAN
A:
[24-210]
---
I
N
Q
N
G
W
I
E
V
I
C
G
S
M
F
S
G
K
S
E
E
L
I
R
R
V
R
R
T
Q
F
A
K
Q
H
A
I
V
F
K
P
C
-----------------
V
K
A
V
P
----
V
-
S
A
S
K
D
I
F
K
-----
H
I
-----
T
E
E
M
D
V
I
A
I
D
E
V
Q
F
F
D
G
D
I
V
E
V
V
Q
V
L
A
N
R
G
Y
R
V
I
V
A
G
L
D
Q
D
F
R
G
L
P
F
G
Q
V
P
Q
L
M
A
I
A
E
H
V
T
K
L
Q
A
V
C
S
A
C
G
-
S
-
P
-
A
S
R
T
Q
R
L
I
D
G
E
P
A
A
F
D
D
P
I
I
L
V
G
A
S
E
S
Y
E
P
R
C
R
H
C
H
A
V
P
-----
76
HHSearch
83.94
62%
-106
- C10 -
1XX6
2
KITH_CLOAB
A:
[2-190]
-
Y
R
P
K
D
H
G
W
V
E
V
I
V
G
P
M
Y
S
G
K
S
E
E
L
I
R
R
I
R
R
A
K
I
A
K
Q
K
I
Q
V
F
K
P
E
-------
E
D
V
V
S
H
M
G
E
K
E
Q
A
V
A
----
I
-
K
N
S
R
E
I
L
K
-----
Y
F
-----
E
E
D
T
E
V
I
A
I
D
E
V
Q
F
F
D
D
E
I
V
E
I
V
N
K
I
A
E
S
G
R
R
V
I
C
A
G
L
D
M
D
F
R
G
K
P
F
G
P
I
P
E
L
M
A
I
A
E
F
V
D
K
I
Q
A
I
C
V
V
C
G
-
N
-
P
-
A
T
R
T
Q
R
L
I
N
G
K
P
A
F
Y
D
D
P
V
-----
M
E
S
Y
E
A
R
C
R
K
C
H
V
V
P
-----
22
PsiBlast_CBE
74.68
46%
-29
- C10 -
2UZ3
3
KITH_UREPA
D:
[31-220]
------
I
G
W
I
E
F
I
T
G
P
M
F
A
G
K
T
A
E
L
I
R
R
L
H
R
L
E
Y
A
D
V
K
Y
L
V
F
K
P
K
I
D
T
R
-
S
I
R
N
I
Q
S
R
T
G
T
S
L
P
S
V
E
----
V
-
E
S
A
P
E
I
L
N
-----
Y
I
MSNSF
N
D
E
T
K
V
I
G
I
D
E
V
Q
F
F
D
D
R
I
C
E
V
A
N
I
L
A
E
N
G
F
V
V
I
I
S
G
L
D
K
N
F
K
G
E
P
F
G
P
I
A
K
L
F
T
Y
A
D
K
I
T
K
L
T
A
I
C
N
E
C
G
-
A
-
E
-
A
T
H
S
L
R
K
I
D
G
K
H
A
D
Y
N
D
D
I
V
K
I
G
C
Q
E
F
Y
S
A
V
C
R
H
H
H
K
V
P
N
R
---
51
PsiBlast_CBE
73.86
37%
-135
- C10 -
1XBT
2
KITH_HUMAN
C:
[18-186]
------
R
G
Q
I
Q
V
I
L
G
P
M
F
S
G
K
S
T
E
L
M
R
R
V
R
R
F
Q
I
A
Q
Y
K
C
L
V
I
K
Y
A
K
D
T
R
---------------
A
L
P
----
A
-
C
L
L
R
D
V
A
Q
-----
E
------
A
L
G
V
A
V
I
G
I
D
E
G
Q
F
F
P
-
D
I
V
E
F
C
E
A
M
A
N
A
G
K
T
V
I
V
A
A
L
D
G
T
F
Q
R
K
P
F
G
A
I
L
N
L
V
P
L
A
E
S
V
V
K
L
T
A
V
C
M
E
C
F
-
R
-
E
-
A
A
Y
T
K
R
L
------
G
T
E
K
E
V
E
V
I
G
G
A
D
K
Y
H
S
V
C
R
-----------
24
PsiBlast_CBE
73.49
46%
-24
- C10 -
2UZ3
3
KITH_UREPA
B:
[31-220]
------
I
G
W
I
E
F
I
T
G
P
M
F
A
G
K
T
A
E
L
I
R
R
L
H
R
L
E
Y
A
D
V
K
Y
L
V
F
K
P
K
I
D
T
R
-
S
I
R
N
I
Q
S
R
T
G
T
S
L
P
S
V
E
----
V
-
E
S
A
P
E
I
L
N
-----
Y
I
M
SNSF
N
D
E
T
K
V
I
G
I
D
E
V
Q
F
F
D
D
R
I
C
E
V
A
N
I
L
A
E
N
G
F
V
V
I
I
S
G
L
D
K
N
F
K
G
E
P
F
G
P
I
A
K
L
F
T
Y
A
D
K
I
T
K
L
T
A
I
C
N
E
C
G
-
A
-
E
-
A
T
H
S
L
R
K
I
D
G
K
H
A
D
Y
N
D
D
I
V
K
I
G
C
Q
E
F
Y
S
A
V
C
R
H
H
H
K
V
P
N
R
---
12
PsiBlast_PDB
72.99
37%
-132
- C10 -
1XBT
3
KITH_HUMAN
A:
[18-186]
------
R
G
Q
I
Q
V
I
L
G
P
M
F
S
G
K
S
T
E
L
M
R
R
V
R
R
F
Q
I
A
Q
Y
K
C
L
V
I
K
Y
A
K
D
T
R
---------------
A
L
P
----
A
-
C
L
L
R
D
V
A
Q
-----
E
------
A
L
G
V
A
V
I
G
I
D
E
G
Q
F
F
P
-
D
I
V
E
F
C
E
A
M
A
N
A
G
K
T
V
I
V
A
A
L
D
G
T
F
Q
R
K
P
F
G
A
I
L
N
L
V
P
L
A
E
S
V
V
K
L
T
A
V
C
M
E
C
F
-
R
-
E
-
A
A
Y
T
K
R
L
------
G
T
E
K
E
V
E
V
I
G
G
A
D
K
Y
H
S
V
C
R
-----------
3
PsiBlast_PDB
72.76
46%
-25
- C10 -
2B8T
2
KITH_UREPA
A:
[11-200]
------
I
G
W
I
E
F
I
T
G
P
M
F
A
G
K
T
A
E
L
I
R
R
L
H
R
L
E
Y
A
D
V
K
Y
L
V
F
K
P
K
I
D
T
R
-
S
I
R
N
I
Q
S
R
T
G
T
S
L
P
S
V
E
----
V
-
E
S
A
P
E
I
L
N
-----
Y
I
M
SNSF
N
D
E
T
K
V
I
G
I
D
E
V
Q
F
F
D
D
R
I
C
E
V
A
N
I
L
A
E
N
G
F
V
V
I
I
S
G
L
D
K
N
F
K
G
E
P
F
G
P
I
A
K
L
F
T
Y
A
D
K
I
T
K
L
T
A
I
C
N
E
C
G
-
A
-
E
-
A
T
H
S
L
R
K
I
D
G
K
H
A
D
Y
N
D
D
I
V
K
I
G
C
Q
E
F
Y
S
A
V
C
R
H
H
H
K
V
P
N
R
---
41
PsiBlast_CBE
72.63
37%
-136
- C10 -
1W4R
2
KITH_HUMAN
F:
[19-187]
------
R
G
Q
I
Q
V
I
L
G
P
M
F
S
G
K
S
T
E
L
M
R
R
V
R
R
F
Q
I
A
Q
Y
K
C
L
V
I
K
Y
A
K
D
T
R
Y
--------------
A
L
P
----
A
-
C
L
L
R
D
V
A
Q
-----
E
------
A
L
G
V
A
V
I
G
I
D
E
G
Q
F
F
P
-
D
I
V
E
F
C
E
A
M
A
N
A
G
K
T
V
I
V
A
A
L
D
G
T
F
Q
R
K
P
F
G
A
I
L
N
L
V
P
L
A
E
S
V
V
K
L
T
A
V
C
M
E
C
F
-
R
-
E
-
A
A
Y
T
K
R
L
------
G
T
E
K
E
V
E
V
I
G
G
A
D
K
Y
H
S
V
C
R
-----------
50
PsiBlast_CBE
72.36
37%
-132
- C10 -
1XBT
2
KITH_HUMAN
D:
[18-186]
------
R
G
Q
I
Q
V
I
L
G
P
M
F
S
G
K
S
T
E
L
M
R
R
V
R
R
F
Q
I
A
Q
Y
K
C
L
V
I
K
Y
A
K
D
T
R
Y
S
-------------
A
L
P
----
A
-
C
L
L
R
D
V
A
Q
-----
E
------
A
L
G
V
A
V
I
G
I
D
E
G
Q
F
F
P
-
D
I
V
E
F
C
E
A
M
A
N
A
G
K
T
V
I
V
A
A
L
D
G
T
F
Q
R
K
P
F
G
A
I
L
N
L
V
P
L
A
E
S
V
V
K
L
T
A
V
C
M
E
C
F
-
R
-
E
-
A
A
Y
T
K
R
L
------
G
T
E
K
E
V
E
V
I
G
G
A
D
K
Y
H
S
V
C
R
-----------
73
HHSearch
72.34
47%
-24
- C10 -
2B8T
2
KITH_UREPA
A:
[11-200]
------
I
G
W
I
E
F
I
T
G
P
M
F
A
G
K
T
A
E
L
I
R
R
L
H
R
L
E
Y
A
D
V
K
Y
L
V
F
K
P
K
I
D
T
R
S
I
-
R
N
I
Q
S
R
T
G
T
S
L
P
S
V
E
----
V
-
E
S
A
P
E
I
L
N
Y
I
M
SN
S
F
-----
N
D
E
T
K
V
I
G
I
D
E
V
Q
F
F
D
D
R
I
C
E
V
A
N
I
L
A
E
N
G
F
V
V
I
I
S
G
L
D
K
N
F
K
G
E
P
F
G
P
I
A
K
L
F
T
Y
A
D
K
I
T
K
L
T
A
I
C
N
E
C
G
-
A
-
E
-
A
T
H
S
L
R
K
I
D
G
K
H
A
D
Y
N
D
D
I
V
K
I
G
C
Q
E
F
Y
S
A
V
C
R
H
H
H
K
V
P
N
R
---
58
PsiBlast_CBE
72.32
36%
-133
- C10 -
2WVJ
2
KITH_HUMAN
C:
[18-186]
------
R
G
Q
I
Q
V
I
L
G
P
M
F
S
G
K
S
T
E
L
M
R
R
V
R
R
F
Q
I
A
Q
Y
K
C
L
V
I
K
Y
A
K
D
T
R
---------------
A
L
P
----
A
-
C
L
L
R
D
V
A
Q
-----
E
------
A
L
G
V
A
V
I
G
I
D
E
G
Q
F
F
P
-
D
I
V
E
F
C
E
A
M
A
N
A
G
K
T
V
I
V
A
A
L
D
G
T
F
Q
R
K
P
F
G
A
I
L
N
L
V
P
L
A
E
S
V
V
K
L
T
A
V
C
M
E
C
F
-
R
-
E
-
A
A
Y
S
K
R
L
------
G
T
E
K
E
V
E
V
I
G
G
A
D
K
Y
H
S
V
C
R
-----------
43
PsiBlast_CBE
72.25
37%
-127
- C10 -
1W4R
2
KITH_HUMAN
D:
[19-187]
------
R
G
Q
I
Q
V
I
L
G
P
M
F
S
G
K
S
T
E
L
M
R
R
V
R
R
F
Q
I
A
Q
Y
K
C
L
V
I
K
Y
A
K
D
T
R
---------------
A
L
P
----
A
-
C
L
L
R
D
V
A
Q
-----
E
------
A
L
G
V
A
V
I
G
I
D
E
G
Q
F
F
P
-
D
I
V
E
F
C
E
A
M
A
N
A
G
K
T
V
I
V
A
A
L
D
G
T
F
Q
R
K
P
F
G
A
I
L
N
L
V
P
L
A
E
S
V
V
K
L
T
A
V
C
M
E
C
F
-
R
-
E
-
A
A
Y
T
K
R
L
------
G
T
E
K
E
V
E
V
I
G
G
A
D
K
Y
H
S
V
C
R
-----------
57
PsiBlast_CBE
72.20
36%
-128
- C10 -
2WVJ
3
KITH_HUMAN
D:
[18-186]
------
R
G
Q
I
Q
V
I
L
G
P
M
F
S
G
K
S
T
E
L
M
R
R
V
R
R
F
Q
I
A
Q
Y
K
C
L
V
I
K
Y
A
K
D
T
R
Y
S
-------------
A
L
P
----
A
-
C
L
L
R
D
V
A
Q
-----
E
------
A
L
G
V
A
V
I
G
I
D
E
G
Q
F
F
P
-
D
I
V
E
F
C
E
A
M
A
N
A
G
K
T
V
I
V
A
A
L
D
G
T
F
Q
R
K
P
F
G
A
I
L
N
L
V
P
L
A
E
S
V
V
K
L
T
A
V
C
M
E
C
F
-
R
-
E
-
A
A
Y
S
K
R
L
------
G
T
E
K
E
V
E
V
I
G
G
A
D
K
Y
H
S
V
C
R
-----------
52
PsiBlast_CBE
71.97
37%
-134
- C10 -
1XBT
3
KITH_HUMAN
B:
[18-186]
------
R
G
Q
I
Q
V
I
L
G
P
M
F
S
G
K
S
T
E
L
M
R
R
V
R
R
F
Q
I
A
Q
Y
K
C
L
V
I
K
Y
A
K
D
T
R
---------------
A
L
P
----
A
-
C
L
L
R
D
V
A
Q
-----
E
------
A
L
G
V
A
V
I
G
I
D
E
G
Q
F
F
P
-
D
I
V
E
F
C
E
A
M
A
N
A
G
K
T
V
I
V
A
A
L
D
G
T
F
Q
R
K
P
F
G
A
I
L
N
L
V
P
L
A
E
S
V
V
K
L
T
A
V
C
M
E
C
F
-
R
-
E
-
A
A
Y
T
K
R
L
------
G
T
E
K
E
V
E
V
I
G
G
A
D
K
Y
H
S
V
C
R
-----------
42
PsiBlast_CBE
71.83
37%
-133
- C10 -
1W4R
3
KITH_HUMAN
E:
[19-187]
------
R
G
Q
I
Q
V
I
L
G
P
M
F
S
G
K
S
T
E
L
M
R
R
V
R
R
F
Q
I
A
Q
Y
K
C
L
V
I
K
Y
A
K
D
T
R
---------------
A
L
P
----
A
-
C
L
L
R
D
V
A
Q
-----
E
------
A
L
G
V
A
V
I
G
I
D
E
G
Q
F
F
P
-
D
I
V
E
F
C
E
A
M
A
N
A
G
K
T
V
I
V
A
A
L
D
G
T
F
Q
R
K
P
F
G
A
I
L
N
L
V
P
L
A
E
S
V
V
K
L
T
A
V
C
M
E
C
F
-
R
-
E
-
A
A
Y
T
K
R
L
------
G
T
E
K
E
V
E
V
I
G
G
A
D
K
Y
H
S
V
C
R
-----------
40
PsiBlast_CBE
71.69
37%
-130
- C10 -
1W4R
2
KITH_HUMAN
G:
[19-187]
------
R
G
Q
I
Q
V
I
L
G
P
M
F
S
G
K
S
T
E
L
M
R
R
V
R
R
F
Q
I
A
Q
Y
K
C
L
V
I
K
Y
A
K
D
T
R
---------------
A
L
P
----
A
-
C
L
L
R
D
V
A
Q
-----
E
------
A
L
G
V
A
V
I
G
I
D
E
G
Q
F
F
P
-
D
I
V
E
F
C
E
A
M
A
N
A
G
K
T
V
I
V
A
A
L
D
G
T
F
Q
R
K
P
F
G
A
I
L
N
L
V
P
L
A
E
S
V
V
K
L
T
A
V
C
M
E
C
F
-
R
-
E
-
A
A
Y
T
K
R
L
------
G
T
E
K
E
V
E
V
I
G
G
A
D
K
Y
H
S
V
C
R
-----------
59
PsiBlast_CBE
71.65
36%
-133
- C10 -
2WVJ
2
KITH_HUMAN
B:
[18-186]
------
R
G
Q
I
Q
V
I
L
G
P
M
F
S
G
K
S
T
E
L
M
R
R
V
R
R
F
Q
I
A
Q
Y
K
C
L
V
I
K
Y
A
K
D
T
R
---------------
A
L
P
----
A
-
C
L
L
R
D
V
A
Q
-----
E
------
A
L
G
V
A
V
I
G
I
D
E
G
Q
F
F
P
-
D
I
V
E
F
C
E
A
M
A
N
A
G
K
T
V
I
V
A
A
L
D
G
T
F
Q
R
K
P
F
G
A
I
L
N
L
V
P
L
A
E
S
V
V
K
L
T
A
V
C
M
E
C
F
-
R
-
E
-
A
A
Y
S
K
R
L
------
G
T
E
K
E
V
E
V
I
G
G
A
D
K
Y
H
S
V
C
R
-----------
46
PsiBlast_CBE
71.58
37%
-132
- C10 -
1XBT
8
KITH_HUMAN
H:
[18-186]
------
R
G
Q
I
Q
V
I
L
G
P
M
F
S
G
K
S
T
E
L
M
R
R
V
R
R
F
Q
I
A
Q
Y
K
C
L
V
I
K
Y
A
K
D
T
R
Y
--------------
A
L
P
----
A
-
C
L
L
R
D
V
A
Q
-----
E
------
A
L
G
V
A
V
I
G
I
D
E
G
Q
F
F
P
-
D
I
V
E
F
C
E
A
M
A
N
A
G
K
T
V
I
V
A
A
L
D
G
T
F
Q
R
K
P
F
G
A
I
L
N
L
V
P
L
A
E
S
V
V
K
L
T
A
V
C
M
E
C
F
-
R
-
E
-
A
A
Y
T
K
R
L
------
G
T
E
K
E
V
E
V
I
G
G
A
D
K
Y
H
S
V
C
R
-----------
14
PsiBlast_PDB
71.42
36%
-133
- C10 -
2WVJ
2
KITH_HUMAN
A:
[18-186]
------
R
G
Q
I
Q
V
I
L
G
P
M
F
S
G
K
S
T
E
L
M
R
R
V
R
R
F
Q
I
A
Q
Y
K
C
L
V
I
K
Y
A
K
D
T
R
---------------
A
L
P
----
A
-
C
L
L
R
D
V
A
Q
-----
E
------
A
L
G
V
A
V
I
G
I
D
E
G
Q
F
F
P
-
D
I
V
E
F
C
E
A
M
A
N
A
G
K
T
V
I
V
A
A
L
D
G
T
F
Q
R
K
P
F
G
A
I
L
N
L
V
P
L
A
E
S
V
V
K
L
T
A
V
C
M
E
C
F
-
R
-
E
-
A
A
Y
S
K
R
L
------
G
T
E
K
E
V
E
V
I
G
G
A
D
K
Y
H
S
V
C
R
-----------
53
PsiBlast_CBE
71.07
37%
-141
- C10 -
2ORV
2
KITH_HUMAN
B:
[18-186]
------
R
G
Q
I
Q
V
I
L
G
P
M
F
S
G
K
S
T
E
L
M
R
R
V
R
R
F
Q
I
A
Q
Y
K
C
L
V
I
K
Y
A
K
D
---------------
M
E
A
L
P
----
A
-
C
L
L
R
D
V
A
Q
-----
E
------
A
L
G
V
A
V
I
G
I
D
E
G
Q
F
F
P
-
D
I
V
E
F
C
E
A
M
A
N
A
G
K
T
V
I
V
A
A
L
D
G
T
F
Q
R
K
P
F
G
A
I
L
N
L
V
P
L
A
E
S
V
V
K
L
T
A
V
C
M
E
C
F
-
R
-
E
-
A
A
Y
T
K
R
L
------
G
T
E
K
E
V
E
V
I
G
G
A
D
K
Y
H
S
V
C
R
-----------
29
PsiBlast_CBE
70.85
37%
-132
- C10 -
2ORW
3
KITH_THEMA
B:
[2-174]
------
S
G
K
L
T
V
I
T
G
P
M
Y
S
G
K
T
T
E
L
L
S
F
V
E
I
Y
K
L
G
K
K
K
V
A
V
F
K
P
K
I
D
-----
T
M
I
V
S
H
---
G
V
E
A
H
V
----
I
-
E
R
P
E
E
M
R
K
-----
Y
I
-----
E
E
D
T
R
G
V
F
I
D
E
V
Q
F
F
N
P
S
L
F
E
V
V
K
D
L
L
D
R
G
I
D
V
F
C
A
G
L
D
L
T
H
K
Q
N
P
F
E
T
T
A
L
L
L
S
L
A
D
T
V
I
K
K
K
A
V
C
H
R
C
G
-
E
Y
N
-
A
T
L
T
L
K
V
A
G
G
E
E
E
------
I
D
V
G
G
Q
E
K
Y
I
A
V
C
R
-----------
62
PsiBlast_CBE
70.57
34%
-125
- C10 -
2J87
3
KITH_VACCA
B:
[4-171]
-------
G
H
I
Q
L
I
I
G
P
M
F
S
G
K
S
T
E
L
I
R
R
V
R
R
Y
Q
I
A
Q
Y
K
C
V
T
I
K
Y
S
N
D
N
---------
H
D
K
N
N
F
E
A
L
E
----
A
-
T
K
L
C
D
V
L
Q
-----
S
I
-----
T
D
F
S
-
V
I
G
I
D
E
G
Q
F
F
P
-
D
I
V
E
F
C
E
R
M
A
N
E
G
K
I
V
I
V
A
A
L
D
G
T
F
Q
R
K
P
F
N
N
I
L
N
L
L
I
L
S
E
M
V
V
K
L
T
A
V
C
M
K
C
F
-
K
-
E
-
A
S
F
S
K
R
L
------
G
E
E
T
E
I
E
I
I
G
G
N
D
M
Y
Q
S
V
C
R
-----------
60
PsiBlast_CBE
70.45
34%
-128
- C10 -
2J87
3
KITH_VACCA
D:
[4-171]
-------
G
H
I
Q
L
I
I
G
P
M
F
S
G
K
S
T
E
L
I
R
R
V
R
R
Y
Q
I
A
Q
Y
K
C
V
T
I
K
Y
S
N
D
N
R
Y
G
-
T
--
W
T
H
D
K
N
N
F
E
A
L
E
----
A
-
T
K
L
C
D
V
L
Q
-----
S
I
-----
T
D
F
S
-
V
I
G
I
D
E
G
Q
F
F
P
-
D
I
V
E
F
C
E
R
M
A
N
E
G
K
I
V
I
V
A
A
L
D
G
T
F
Q
R
K
P
F
N
N
I
L
N
L
L
I
L
S
E
M
V
V
K
L
T
A
V
C
M
K
C
F
-
K
-
E
-
A
S
F
S
K
R
L
------
G
E
E
T
E
I
E
I
I
G
G
N
D
M
Y
Q
S
V
C
R
-----------
75
HHSearch
70.40
38%
-121
- C10 -
2ORW
3
KITH_THEMA
A:
[2-181]
------
S
G
K
L
T
V
I
T
G
P
M
Y
S
G
K
T
T
E
L
L
S
F
V
E
I
Y
K
L
G
K
K
K
V
A
V
F
K
P
K
-----
H
S
T
M
I
V
S
----
G
V
E
A
H
V
----
I
-
E
R
P
E
E
M
R
K
-----
Y
I
-----
E
E
D
T
R
G
V
F
I
D
E
V
Q
F
F
N
P
S
L
F
E
V
V
K
D
L
L
D
R
G
I
D
V
F
C
A
G
L
D
L
T
H
K
Q
N
P
F
E
T
T
A
L
L
L
S
L
A
D
T
V
I
K
K
K
A
V
C
H
R
C
G
-
E
-
Y
N
A
T
L
T
L
K
V
A
G
G
------
E
E
E
I
D
V
G
G
Q
E
K
Y
I
A
V
C
R
D
C
Y
N
T
L
K
----
6
PsiBlast_PDB
69.77
37%
-132
- C10 -
2QQ0
4
KITH_THEMA
A:
[2-174]
------
S
G
K
L
T
V
I
T
G
P
M
Y
S
G
K
T
T
E
L
L
S
F
V
E
I
Y
K
L
G
K
K
K
V
A
V
F
K
P
K
-------
T
M
I
V
S
H
----
V
E
A
H
V
----
I
-
E
R
P
E
E
M
R
K
-----
Y
I
-----
E
E
D
T
R
G
V
F
I
D
E
V
Q
F
F
N
P
S
L
F
E
V
V
K
D
L
L
D
R
G
I
D
V
F
C
A
G
L
D
L
T
H
K
Q
N
P
F
E
T
T
A
L
L
L
S
L
A
D
T
V
I
K
K
K
A
V
C
H
R
C
G
-
E
Y
N
-
A
T
L
T
L
K
V
A
G
G
E
E
E
------
I
D
V
G
G
Q
E
K
Y
I
A
V
C
R
-----------
26
PsiBlast_CBE
69.59
37%
-134
- C10 -
2QQ0
4
KITH_THEMA
B:
[2-174]
------
S
G
K
L
T
V
I
T
G
P
M
Y
S
G
K
T
T
E
L
L
S
F
V
E
I
Y
K
L
G
K
K
K
V
A
V
F
K
P
K
------
S
T
M
I
V
S
H
----
V
E
A
H
V
----
I
-
E
R
P
E
E
M
R
K
-----
Y
I
-----
E
E
D
T
R
G
V
F
I
D
E
V
Q
F
F
N
P
S
L
F
E
V
V
K
D
L
L
D
R
G
I
D
V
F
C
A
G
L
D
L
T
H
K
Q
N
P
F
E
T
T
A
L
L
L
S
L
A
D
T
V
I
K
K
K
A
V
C
H
R
C
G
-
E
Y
N
-
A
T
L
T
L
K
V
A
G
G
E
E
E
------
I
D
V
G
G
Q
E
K
Y
I
A
V
C
R
-----------
7
PsiBlast_PDB
69.48
37%
-125
- C10 -
2QQE
2
KITH_THEMA
A:
[2-174]
------
S
G
K
L
T
V
I
T
G
P
M
Y
S
G
K
T
T
E
L
L
S
F
V
E
I
Y
K
L
G
K
K
K
V
A
V
F
K
P
K
---------------
N
G
V
E
A
H
V
----
I
-
E
R
P
E
E
M
R
K
-----
Y
I
-----
E
E
D
T
R
G
V
F
I
D
E
V
Q
F
F
N
P
S
L
F
E
V
V
K
D
L
L
D
R
G
I
D
V
F
C
A
G
L
D
L
T
H
K
Q
N
P
F
E
T
T
A
L
L
L
S
L
A
D
T
V
I
K
K
K
A
V
C
H
R
C
G
-
E
Y
N
-
A
T
L
T
L
K
V
A
G
-
E
E
E
------
I
D
V
G
G
Q
E
K
Y
I
A
V
C
R
-----------
4
PsiBlast_PDB
68.82
37%
-127
- C10 -
2ORW
3
KITH_THEMA
A:
[2-174]
------
S
G
K
L
T
V
I
T
G
P
M
Y
S
G
K
T
T
E
L
L
S
F
V
E
I
Y
K
L
G
K
K
K
V
A
V
F
K
P
K
-----
H
S
T
M
I
V
S
----
G
V
E
A
H
V
----
I
-
E
R
P
E
E
M
R
K
-----
Y
I
-----
E
E
D
T
R
G
V
F
I
D
E
V
Q
F
F
N
P
S
L
F
E
V
V
K
D
L
L
D
R
G
I
D
V
F
C
A
G
L
D
L
T
H
K
Q
N
P
F
E
T
T
A
L
L
L
S
L
A
D
T
V
I
K
K
K
A
V
C
H
R
C
G
-
E
Y
N
-
A
T
L
T
L
K
V
A
G
G
E
E
E
------
I
D
V
G
G
Q
E
K
Y
I
A
V
C
R
-----------
77
HHSearch
68.73
38%
-140
* C10 *
2ORV
2
KITH_HUMAN
A:
[18-191]
------
R
G
Q
I
Q
V
I
L
G
P
M
F
S
G
K
S
T
E
L
M
R
R
V
R
R
F
Q
I
A
Q
Y
K
C
L
V
I
K
Y
A
K
D
T
R
Y
------------
M
E
A
L
P
----
A
-
C
L
L
R
D
V
A
Q
------
E
-----
A
L
G
V
A
V
I
G
I
D
E
G
Q
F
F
P
D
-
I
V
E
F
C
E
A
M
A
N
A
G
K
T
V
I
V
A
A
L
D
G
T
F
Q
R
K
P
F
G
A
I
L
N
L
V
P
L
A
E
S
V
V
K
L
T
A
V
C
M
E
C
F
-
R
-
E
-
A
A
Y
T
K
R
L
G
T
E
------
K
E
V
E
V
I
G
G
A
D
K
Y
H
S
V
C
R
L
C
Y
F
K
------
23
PsiBlast_CBE
68.29
46%
-27
- C10 -
2UZ3
2
KITH_UREPA
C:
[31-220]
------
I
G
W
I
E
F
I
T
G
P
M
F
A
G
K
T
A
E
L
I
R
R
L
H
R
L
E
Y
A
D
V
K
Y
L
V
F
K
P
K
----------------
S
L
P
S
V
E
----
V
-
E
S
A
P
E
I
L
N
-----
Y
I
M
SNSF
N
D
E
T
K
V
I
G
I
D
E
V
Q
F
F
D
D
R
I
C
E
V
A
N
I
L
A
E
N
G
F
V
V
I
I
S
G
L
D
K
N
F
K
G
E
P
F
G
P
I
A
K
L
F
T
Y
A
D
K
I
T
K
L
T
A
I
C
N
E
C
G
-
A
-
E
-
A
T
H
S
L
R
K
I
D
G
K
H
A
D
Y
N
D
D
I
V
K
I
G
C
Q
E
F
Y
S
A
V
C
R
H
H
H
K
V
P
N
R
---
21
PsiBlast_CBE
68.03
46%
-28
- C10 -
2B8T
2
KITH_UREPA
B:
[11-200]
------
I
G
W
I
E
F
I
T
G
P
M
F
A
G
K
T
A
E
L
I
R
R
L
H
R
L
E
Y
A
D
V
K
Y
L
V
F
K
P
K
I
----------------
L
P
S
V
E
----
V
-
E
S
A
P
E
I
L
N
-----
Y
I
M
SNSF
N
D
E
T
K
V
I
G
I
D
E
V
Q
F
F
D
D
R
I
C
E
V
A
N
I
L
A
E
N
G
F
V
V
I
I
S
G
L
D
K
N
F
K
G
E
P
F
G
P
I
A
K
L
F
T
Y
A
D
K
I
T
K
L
T
A
I
C
N
E
C
G
-
A
-
E
-
A
T
H
S
L
R
K
I
D
G
K
H
A
D
Y
N
D
D
I
V
K
I
G
C
Q
E
F
Y
S
A
V
C
R
H
H
H
K
V
P
N
R
---
13
PsiBlast_PDB
67.99
37%
-133
- C10 -
2ORV
2
KITH_HUMAN
A:
[18-186]
------
R
G
Q
I
Q
V
I
L
G
P
M
F
S
G
K
S
T
E
L
M
R
R
V
R
R
F
Q
I
A
Q
Y
K
C
L
V
I
K
Y
A
K
D
T
R
Y
------------
M
E
A
L
P
----
A
-
C
L
L
R
D
V
A
Q
-----
E
------
A
L
G
V
A
V
I
G
I
D
E
G
Q
F
F
P
-
D
I
V
E
F
C
E
A
M
A
N
A
G
K
T
V
I
V
A
A
L
D
G
T
F
Q
R
K
P
F
G
A
I
L
N
L
V
P
L
A
E
S
V
V
K
L
T
A
V
C
M
E
C
F
-
R
-
E
-
A
A
Y
T
K
R
L
------
G
T
E
K
E
V
E
V
I
G
G
A
D
K
Y
H
S
V
C
R
-----------
25
PsiBlast_CBE
67.17
37%
-131
- C10 -
2QQE
2
KITH_THEMA
B:
[2-174]
------
S
G
K
L
T
V
I
T
G
P
M
Y
S
G
K
T
T
E
L
L
S
F
V
E
I
Y
K
L
G
K
K
K
V
A
V
F
K
P
K
-----------------
V
E
A
H
V
----
I
-
E
R
P
E
E
M
R
K
-----
Y
I
-----
E
E
D
T
R
G
V
F
I
D
E
V
Q
F
F
N
P
S
L
F
E
V
V
K
D
L
L
D
R
G
I
D
V
F
C
A
G
L
D
L
T
H
K
Q
N
P
F
E
T
T
A
L
L
L
S
L
A
D
T
V
I
K
K
K
A
V
C
H
R
C
G
-
E
Y
N
-
A
T
L
T
L
K
V
A
-----------
I
D
V
G
G
Q
E
K
Y
I
A
V
C
R
-----------
79
HHSearch
63.39
38%
-57
- C10 -
4UXH
2
?
A:
[4-180]
------
R
G
R
I
E
L
I
I
G
P
M
F
A
G
K
T
T
E
L
M
R
R
V
K
R
E
I
H
A
R
R
S
C
F
V
I
K
Y
S
K
D
T
R
Y
D
E
H
N
V
A
----
L
M
L
R
A
Q
A
----
A
V
S
Q
L
T
E
V
R
D
------
T
-----
W
K
R
F
D
V
L
A
I
D
E
G
Q
F
F
S
D
-
L
V
D
F
C
N
T
A
A
D
A
G
K
V
V
M
V
S
A
L
D
G
D
Y
R
R
K
P
F
G
Q
I
C
E
L
V
P
Y
C
E
A
V
D
K
L
T
A
V
C
M
M
C
H
-
E
Q
P
-
A
C
F
T
R
R
T
V
N
V
------
E
Q
Q
E
L
I
G
G
A
D
M
Y
I
A
T
C
R
E
C
Y
S
K
------
9
PsiBlast_PDB
63.22
37%
-27
- C10 -
4UXH
2
?
A:
[5-175]
-------
G
R
I
E
L
I
I
G
P
M
F
A
G
K
T
T
E
L
M
R
R
V
K
R
E
I
H
A
R
R
S
C
F
V
I
K
Y
S
K
D
T
R
Y
D
E
H
N
V
A
----
L
M
L
R
A
Q
A
A
V
SQ
L
-
T
E
V
R
D
T
W
K
-----
R
F
---------
D
V
L
A
I
D
E
G
Q
F
F
-
S
D
L
V
D
F
C
N
T
A
A
D
A
G
K
V
V
M
V
S
A
L
D
G
D
Y
R
R
K
P
F
G
Q
I
C
E
L
V
P
Y
C
E
A
V
D
K
L
T
A
V
C
M
M
C
H
E
Q
-
P
-
A
C
F
T
R
R
T
V
N
V
E
Q
Q
E
------
L
I
G
G
A
D
M
Y
I
A
T
C
R
-----------
33
PsiBlast_CBE
61.22
37%
-19
- C10 -
4UXJ
3
?
E:
[12-182]
-------
G
R
I
E
L
I
I
G
P
M
F
A
G
K
T
T
E
L
M
R
R
V
K
R
E
I
H
A
R
R
S
C
F
V
I
K
Y
S
K
D
T
R
Y
D
E
H
N
V
A
S
-------
A
Q
A
A
V
SQ
L
-
T
E
V
R
D
T
W
K
-----
R
F
---------
D
V
L
A
I
D
E
G
Q
F
F
-
S
D
L
V
D
F
C
N
T
A
A
D
A
G
K
V
V
M
V
S
A
L
D
G
D
Y
R
R
K
P
F
G
Q
I
C
E
L
V
P
Y
C
E
A
V
D
K
L
T
A
V
C
M
M
C
H
E
Q
-
P
-
A
C
F
T
R
R
T
V
N
V
E
Q
Q
E
------
L
I
G
G
A
D
M
Y
I
A
T
C
R
-----------
8
PsiBlast_PDB
61.17
37%
-22
- C10 -
4UXJ
3
?
A:
[12-182]
-------
G
R
I
E
L
I
I
G
P
M
F
A
G
K
T
T
E
L
M
R
R
V
K
R
E
I
H
A
R
R
S
C
F
V
I
K
Y
S
-------------
D
Q
L
M
L
R
A
Q
A
A
V
SQ
L
-
T
E
V
R
D
T
W
K
-----
R
F
---------
D
V
L
A
I
D
E
G
Q
F
F
-
S
D
L
V
D
F
C
N
T
A
A
D
A
G
K
V
V
M
V
S
A
L
D
G
D
Y
R
R
K
P
F
G
Q
I
C
E
L
V
P
Y
C
E
A
V
D
K
L
T
A
V
C
M
M
C
H
E
Q
-
P
-
A
C
F
T
R
R
T
V
N
V
E
Q
Q
E
------
L
I
G
G
A
D
M
Y
I
A
T
C
R
-----------
36
PsiBlast_CBE
59.75
37%
-27
- C10 -
4UXJ
3
?
B:
[12-182]
-------
G
R
I
E
L
I
I
G
P
M
F
A
G
K
T
T
E
L
M
R
R
V
K
R
E
I
H
A
R
R
S
C
F
V
I
K
Y
S
-----------
S
H
D
Q
L
M
L
R
A
Q
A
A
V
SQ
L
-
T
E
V
R
D
T
W
K
-----
R
F
---------
D
V
L
A
I
D
E
G
Q
F
F
-
S
D
L
V
D
F
C
N
T
A
A
D
A
G
K
V
V
M
V
S
A
L
D
G
D
Y
R
R
K
P
F
G
Q
I
C
E
L
V
P
Y
C
E
A
V
D
K
L
T
A
V
C
M
M
C
H
E
Q
-
P
-
A
C
F
T
R
R
T
V
N
V
E
Q
Q
E
------
L
I
G
G
A
D
M
Y
I
A
T
C
R
-----------
38
PsiBlast_CBE
59.67
37%
-21
- C10 -
4UXH
2
?
B:
[5-175]
-------
G
R
I
E
L
I
I
G
P
M
F
A
G
K
T
T
E
L
M
R
R
V
K
R
E
I
H
A
R
R
S
C
F
V
I
K
Y
S
K
D
---------------
L
R
A
Q
A
A
V
SQ
L
-
T
E
V
R
D
T
W
K
-----
R
F
---------
D
V
L
A
I
D
E
G
Q
F
F
-
S
D
L
V
D
F
C
N
T
A
A
D
A
G
K
V
V
M
V
S
A
L
D
G
D
Y
R
R
K
P
F
G
Q
I
C
E
L
V
P
Y
C
E
A
V
D
K
L
T
A
V
C
M
M
C
H
E
Q
-
P
-
A
C
F
T
R
R
T
V
N
V
E
Q
Q
E
------
L
I
G
G
A
D
M
Y
I
A
T
C
R
-----------
35
PsiBlast_CBE
59.59
37%
-17
- C10 -
4UXJ
3
?
C:
[12-182]
-------
G
R
I
E
L
I
I
G
P
M
F
A
G
K
T
T
E
L
M
R
R
V
K
R
E
I
H
A
R
R
S
C
F
V
I
K
Y
S
K
D
T
R
Y
D
E
H
N
V
A
------
L
R
A
Q
A
A
V
SQ
L
-
T
E
V
R
D
T
W
K
-----
R
F
---------
D
V
L
A
I
D
E
G
Q
F
F
-
S
D
L
V
D
F
C
N
T
A
A
D
A
G
K
V
V
M
V
S
A
L
D
G
D
Y
R
R
K
P
F
G
Q
I
C
E
L
V
P
Y
C
E
A
V
D
K
L
T
A
V
C
M
M
C
H
E
Q
-
P
-
A
C
F
T
R
R
T
V
N
V
E
Q
Q
E
------
L
I
G
G
A
D
M
Y
I
A
T
C
R
-----------
34
PsiBlast_CBE
59.26
37%
-21
- C10 -
4UXJ
3
?
D:
[12-182]
-------
G
R
I
E
L
I
I
G
P
M
F
A
G
K
T
T
E
L
M
R
R
V
K
R
E
I
H
A
R
R
S
C
F
V
I
K
Y
------------------
L
R
A
Q
A
A
V
SQ
L
-
T
E
V
R
D
T
W
K
-----
R
F
---------
D
V
L
A
I
D
E
G
Q
F
F
-
S
D
L
V
D
F
C
N
T
A
A
D
A
G
K
V
V
M
V
S
A
L
D
G
D
Y
R
R
K
P
F
G
Q
I
C
E
L
V
P
Y
C
E
A
V
D
K
L
T
A
V
C
M
M
C
H
E
Q
-
P
-
A
C
F
T
R
R
T
V
N
V
E
Q
Q
E
------
L
I
G
G
A
D
M
Y
I
A
T
C
R
-----------
32
PsiBlast_CBE
58.88
37%
-23
- C10 -
4UXJ
3
?
F:
[12-182]
-------
G
R
I
E
L
I
I
G
P
M
F
A
G
K
T
T
E
L
M
R
R
V
K
R
E
I
H
A
R
R
S
C
F
V
I
K
Y
S
K
D
T
R
Y
D
------
H
D
Q
L
M
L
R
A
Q
A
AVSQ
L
-
T
E
V
R
D
T
W
K
-----
R
F
---------
D
V
L
A
I
D
E
G
Q
F
F
-
S
D
L
V
D
F
C
N
T
A
A
D
A
G
K
V
V
M
V
S
A
L
D
G
D
Y
R
R
K
P
F
G
Q
I
C
E
L
V
P
Y
C
E
A
V
D
K
L
T
A
V
C
M
M
C
H
E
Q
-
P
-
A
C
F
T
R
R
T
V
N
V
E
Q
Q
E
------
L
I
G
G
A
D
M
Y
I
A
T
C
R
-----------