@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu37080: (2016-08-01 )
MKDVSISSLENMKLKELYELARHYKISYYSKLTKKELIFAILKANAEQEDLLFMEGVLEIIQSEGFGFLRPINYSPSSEDIYISASQIRRFDLRNGDKVSGKVRPPKENERYYGLLHVEAVNGDDPESAKERVHFPALTPLYPDRQMVLETKPNFLSTRIMDMMAPVGFGQRGLIVAPPKAGKTMLLKEIANSITANQPEAELIVLLIDERPEEVTDIERSVAGDVVSSTFDEVPENHIKVAELVLERAMRLVEHKKDVIILMDSITRLARAYNLVIPPSGRTLSGGIDPAAFHRPKRFFGAARNIEEGGSLTILATALVDTGSRMDDVIYEEFKGTGNMELHLDRSLAERRIFPAIDIRRSGTRKEELLVPKEHLDRLWSIRKTMSDSPDFAEKFMRKMKKTKTNQEFFDILNQEWKQANLSSARR
Atome Classification :
(27 SA)
.........10........20........30........40........50........60........70..--......80........90........100.......110.......120.......130.......140.......150-.........160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.....--..390.......400.......410.......420.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKDVSI
S
S
L
EN
M
K
L
K
E
L
Y
E
L
A
R
H
Y
K
I
S
Y
Y
S
KL
T
K
K
E
L
I
F
A
I
L
KANAEQ
E
D
L
L
F
M
E
G
V
L
E
I
I
Q
SEGF
G
F
LRPIN--YSPSSE
D
I
Y
I
S
A
S
Q
I
R
R
F
DLRNGDKVSGKVRPPKENE
R
Y
Y
G
L
L
H
V
E
AVNGDD
P
E
S
A
K
ERVHFPALTPLYPDR
Q
M
V
L
E---TKP
N
F
L
S
T
R
I
M
D
M
MAPVGFGQRG
L
I
V
APPKA
G
K
T
M
L
L
K
E
I
A
N
S
ITANQPE
A
E
L
I
V
L
L
IDERP
E
E
V
T
D
I
E
R
S
V
A
G
D
V
V
S
S
T
F
D
EV
P
E
N
H
I
K
V
A
E
L
V
L
E
R
A
M
R
L
V
EHKK
D
V
I
I
L
M
D
S
I
T
R
L
A
R
A
Y
N
L
V
IPPSGRTLSGGI
D
P
A
A
FH
R
P
K
R
F
F
GAARNIEEGG
S
L
T
I
L
A
T
A
L
VDTGS
R
M
D
D
V
I
Y
E
E
FKGTG
N
M
E
L
H
L
D
R
S
L
A
ERRIF
P
A
I
D
IRRSGTR
K
E
ELLV
P
K
E
H
L
D
R
L
W
S
I
R
K
TMS--DS
P
D
F
A
E
K
F
M
R
K
M
K
KTKT
N
Q
E
F
F
D
I
L
N
Q
E
W
K
QANLSSARR
35
PsiBlast_CBE
100.00
56%
0
- C- -
1XPO
6
RHO_ECOLI
B:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
-
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
PM
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-------------
34
PsiBlast_CBE
100.00
56%
0
- C- -
1XPO
6
RHO_ECOLI
C:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
-
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
PM
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-------------
33
PsiBlast_CBE
100.00
56%
0
- C- -
1XPO
6
RHO_ECOLI
D:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
-
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
PM
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-------------
31
PsiBlast_CBE
100.00
56%
0
- C- -
1XPO
5
RHO_ECOLI
F:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
-
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
PM
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-------------
30
PsiBlast_CBE
100.00
56%
0
- C- -
1XPR
6
RHO_ECOLI
B:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
-
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
PM
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-------------
29
PsiBlast_CBE
100.00
56%
0
- C- -
1XPR
5
RHO_ECOLI
C:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
-
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
PM
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-------------
28
PsiBlast_CBE
100.00
56%
0
- C- -
1XPR
4
RHO_ECOLI
D:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
-
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
PM
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-------------
26
PsiBlast_CBE
100.00
56%
0
- C- -
1XPR
6
RHO_ECOLI
F:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
-
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
PM
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-------------
25
PsiBlast_CBE
100.00
56%
0
- C- -
1XPU
6
RHO_ECOLI
B:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
-
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
PM
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-------------
24
PsiBlast_CBE
100.00
56%
0
- C- -
1XPU
6
RHO_ECOLI
C:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
-
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
PM
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-------------
23
PsiBlast_CBE
100.00
56%
0
- C- -
1XPU
5
RHO_ECOLI
D:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
-
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
PM
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-------------
21
PsiBlast_CBE
100.00
56%
0
- C- -
1XPU
5
RHO_ECOLI
F:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
-
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
PM
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-------------
4
PsiBlast_PDB
100.00
56%
0
- C- -
1XPO
5
RHO_ECOLI
A:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
-
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
PM
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-------------
3
PsiBlast_PDB
100.00
56%
0
- C- -
1XPU
5
RHO_ECOLI
A:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
-
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
PM
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-------------
2
PsiBlast_PDB
100.00
56%
0
- C- -
1XPR
5
RHO_ECOLI
A:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
-
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
PM
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-------------
32
PsiBlast_CBE
99.05
56%
0
- C- -
1XPO
6
RHO_ECOLI
E:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
-
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
----
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
PM
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-------------
27
PsiBlast_CBE
99.05
56%
0
- C- -
1XPR
7
RHO_ECOLI
E:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
-
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
----
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
PM
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-------------
22
PsiBlast_CBE
99.05
56%
0
- C- -
1XPU
6
RHO_ECOLI
E:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
-
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
----
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
PM
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-------------
38
PsiBlast_CBE
82.11
56%
4
- C3 -
1PVO
3
RHO_ECOLI
D:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
-
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
PM
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-------------
1
PsiBlast_PDB
80.63
56%
3
- C3 -
1PVO
3
RHO_ECOLI
A:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
-
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
PM
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-------------
36
PsiBlast_CBE
80.18
56%
6
- C3 -
1PVO
2
RHO_ECOLI
F:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
-
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
PM
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-------------
37
PsiBlast_CBE
79.71
56%
4
- C3 -
1PVO
3
RHO_ECOLI
E:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
-
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
----
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
PM
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-------------
39
PsiBlast_CBE
79.65
56%
6
- C3 -
1PVO
3
RHO_ECOLI
C:
[1-417]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
-
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
--
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
----
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
---
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
F
P
A
I
D
Y
N
R
S
G
T
R
K
E
E
L
L
T
T
Q
E
E
L
Q
K
M
W
I
L
R
K
I
I
H
PM
G
E
I
D
A
M
E
F
L
I
N
K
L
A
M
T
K
T
N
D
D
F
F
E
M
M
K
-------------
41
PsiBlast_CBE
59.00
57%
53
- C3 -
2HT1
3
RHO_ECOLI
B:
[53-376]
---------------------------------
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
-
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
A
R
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
E
RGN
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
S
G
K
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
----------------------------------------------------------------------------
5
PsiBlast_PDB
58.03
57%
61
- C3 -
2HT1
3
RHO_ECOLI
A:
[53-376]
---------------------------------
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
-
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
N
E
V
N
F
D
K
P
E
N
A
R
N
K
I
L
F
E
N
L
T
P
L
H
A
N
S
R
L
R
M
E
RGN
G
S
T
E
D
L
T
A
R
V
L
D
L
A
S
P
I
G
R
G
Q
R
G
L
I
V
A
P
P
K
A
G
K
T
M
L
L
Q
N
I
A
Q
S
I
A
Y
N
H
P
D
C
V
L
M
V
L
L
I
D
E
R
P
E
E
V
T
E
M
Q
R
L
V
K
G
E
V
V
A
S
T
F
D
E
P
A
S
R
H
V
Q
V
A
E
M
V
I
E
K
A
K
R
L
V
E
H
K
K
D
V
I
I
L
L
D
S
I
T
R
L
A
R
A
Y
N
T
V
V
P
A
S
G
K
V
L
T
G
G
V
D
A
N
A
L
H
R
P
K
R
F
F
G
A
A
R
N
V
E
E
G
G
S
L
T
I
I
A
T
A
L
I
D
T
G
S
K
M
D
E
V
I
Y
E
E
F
K
G
T
G
N
M
E
L
H
L
S
R
K
I
A
E
K
R
V
----------------------------------------------------------------------------
10
PsiBlast_PDB
36.66
47%
-92
- C3 -
2A8V
1
RHO_ECOLI
A:
[1-116]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
-
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
32.99
47%
-85
- C3 -
2A8V
1
RHO_ECOLI
B:
[1-116]
---
M
N
L
T
E
L
K
N
T
P
V
S
E
L
I
T
L
G
E
N
M
G
L
E
N
L
A
R
M
R
K
Q
D
I
I
F
A
I
L
K
Q
H
A
K
S
G
E
D
I
F
G
D
G
V
L
E
I
L
Q
-
D
G
F
G
F
L
R
S
A
D
SS
Y
L
A
G
P
D
D
I
Y
V
S
P
S
Q
I
R
R
F
N
L
R
T
G
D
T
I
S
G
K
I
R
P
P
K
E
G
E
R
Y
F
A
L
L
K
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------