@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu37390: (2016-08-02 )
MSILDIHDVSVWYERDNVILEQVDLHLEKGAVYGLLGVNGAGKTTLINTLTGVNRNFSGRFTLCGIEAEAGMPQKTSDQLKTHRYFAADYPLLFTEITAKDYVSFVHSLYQKDFSEQQFASLAEAFHFSKYINRRISELSLGNRQKVVLMTGLLLRAPLFILDEPLVGLDVESIEVFYQKMREYCEAGGTILFSSHLLDVVQRFCDYAAILHNKQIQKVIPIGEETDLRREFFEVIGHE
Atome Classification :
(20 SA)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10...---.-.---...-20........30........40........50........60....---....70.--.......80........90.---------.......100.---...--...--110-.--.--...--...120.......130------....-----------...140.......150.......160.......170-.......180...-.-.-..-190.......200.......210.....-----..220..-----...--..-----230.......------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M
S
I
L
D
I
H
D
V
S
V
W
Y
E---R-D---N
V
I
-
L
E
Q
V
D
L
H
LEKG
A
V
Y
G
L
LGVNGAGK
T
T
L
I
N
T
LTGVNRNFSG
R
F
T
L
C
G
---IEAEAGM--PQK
T
S
D
Q
L
K
T
H
R
Y
FAADY
P
L
---------
L
F
T
EI
T
A
K
D
Y
V
---
S
F
V
--
H
S
L
--
Y
Q
--K--D--F
S
E
--
Q
Q
F
A
S
L
A
E
A
F
H
F
S
K
Y
I
------
N
R
R
I
-----------
S
E
LSLGNR
Q
K
V
V
L
M
T
G
L
L
L
RA
P
L
F
I
LDEPLVGL
D
V
E
-
S
I
E
V
F
Y
Q
K
M
R
E
Y
C
-E-A-G
G
-
T
I
L
F
S
S
H
L
L
D
V
V
Q
R
F
C
D
Y
A
A
I
L
H
N
K
Q
I
Q
-----
K
VIPIGE-----
E
T
D
--
L
R
-----
R
E
F
F
E
V
IGHE------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
77.22
30%
-74
- C1 -
4RVC
-
?
A:
[2-225]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
L
E
V
K
D
L
S
G
G
Y
T
---
A
-
Q
---
N
V
--
L
E
D
V
T
F
V
V
D
R
G
E
M
V
A
L
I
G
L
N
G
A
G
K
S
T
T
I
K
H
I
I
G
L
M
E
P
R
R
G
A
I
S
I
N
G
---
Y
R
L
A
D
G
---
P
E
T
Y
R
R
Q
F
A
----
Y
I
P
E
T
P
V
---------
L
Y
E
E
L
T
L
E
E
H
L
R
L
A
A
M
A
--
Y
G
L
--
S
E
--
A
--
E
--
Y
-
E
--
R
R
L
P
P
L
L
R
E
F
R
L
E
R
R
L
------
S
S
F
P
-----------
A
H
F
S
K
G
M
K
Q
K
V
M
I
V
C
A
F
L
L
E
P
P
L
Y
I
I
D
E
P
F
L
G
L
D
P
L
-
A
I
H
A
L
L
E
R
M
N
E
Q
K
-
A
-
K
-
G
A
-
G
I
L
L
S
T
H
I
L
A
T
A
E
R
Y
C
D
S
F
V
I
L
H
N
G
R
V
K
-----
A
K
---
G
T
-----
L
D
D
--
I
R
-----
R
Q
F
-------------------------------------------------------------------------------------------------------------------
41
HHSearch
74.76
28%
-80
- C1 -
4RVC
-
?
A:
[2-222]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
L
E
V
K
D
L
S
G
G
Y
T
---
A
-----
Q
N
V
-
L
E
D
V
T
F
V
V
D
R
G
E
M
V
A
L
I
G
L
N
G
A
G
K
S
T
T
I
K
H
I
I
G
L
M
E
P
R
R
G
A
I
S
I
N
G
---
Y
R
L
A
D
-------
G
P
E
T
Y
R
R
Q
F
A
Y
I
P
E
T
P
V
---------
L
Y
E
E
L
T
L
E
E
H
L
---
R
L
A
--
A
M
A
--
Y
G
--
L
--
S
E
A
E
Y
E
--
R
R
L
P
P
L
L
R
E
F
R
L
E
R
R
L
------
S
S
F
P
-----------
A
H
F
S
K
G
M
K
Q
K
V
M
I
V
C
A
F
L
L
E
P
P
L
Y
I
I
D
E
P
F
L
G
L
D
P
L
-
A
I
H
A
L
L
E
R
M
N
E
Q
K
-
A
-
K
-
G
A
-
G
I
L
L
S
T
H
I
L
A
T
A
E
R
Y
C
D
S
F
V
I
L
H
N
G
R
V
K
-----
A
K
G
T
L
D
D
-----
I
R
--------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
70.87
29%
-49
- C1 -
1VPL
2
?
A:
[30-224]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
L
K
G
I
S
F
E
I
E
E
G
E
I
F
G
L
I
G
P
N
G
A
G
K
T
T
T
L
R
I
I
S
T
L
I
K
P
S
S
G
I
V
T
V
F
G
-------
K
N
V
--
V
E
E
P
H
E
V
R
K
L
I
S
Y
L
P
E
E
A
G
A
----------
Y
R
N
M
Q
G
I
E
Y
L
---
R
F
V
--
A
G
F
--
Y
A
--
S
--
S
--
S
S
E
I
E
E
M
V
E
R
A
T
E
I
A
G
L
G
E
K
I
------
K
D
R
V
-----------
S
T
Y
S
K
G
M
V
R
K
L
L
I
A
R
A
L
M
V
N
P
R
L
A
I
L
D
E
P
T
S
G
L
D
V
L
-
N
A
R
E
V
R
K
I
L
K
Q
A
S
-
Q
-
E
-
G
L
-
T
I
L
V
S
S
H
N
M
L
E
V
E
F
L
C
D
R
I
A
L
I
H
N
G
T
I
----------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
67.86
27%
-156
- C1 -
1SGW
3
?
A:
[9-204]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
L
E
I
R
D
L
S
V
G
Y
------
D
---
K
P
V
-
L
E
R
I
T
M
T
I
E
K
G
N
V
V
N
F
H
G
P
N
G
I
G
K
T
T
L
L
K
T
I
S
T
Y
L
K
P
L
K
G
E
I
I
Y
N
G
---
V
P
I
T
-----------
K
V
K
G
K
I
F
F
L
P
E
E
I
I
---------
V
P
R
K
I
S
V
E
D
Y
L
---
K
A
V
--
A
S
L
--
Y
G
--
V
--
K
--
V
N
K
--
N
E
I
M
D
A
L
E
S
V
E
V
L
D
-
L
------
K
K
K
L
-----------
G
E
L
S
Q
G
T
I
R
R
V
Q
L
A
S
T
L
L
V
N
A
E
I
Y
V
L
D
D
P
V
V
A
I
D
E
D
-
S
K
H
K
V
L
K
S
I
L
E
I
L
-
K
-
E
-
K
G
-
I
V
I
I
S
S
R
---
E
E
L
S
Y
C
D
V
N
E
N
L
H
--------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
67.80
23%
-126
- C1 -
3D31
-
?
A:
[1-215]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
E
I
E
S
L
S
R
K
W
K
---------
N
F
S
-
L
D
N
L
S
L
K
V
E
S
G
E
Y
F
V
I
L
G
P
T
G
A
G
K
T
L
F
L
E
L
I
A
G
F
H
V
P
D
S
G
R
I
L
L
D
G
---
K
D
V
T
D
--------
L
S
P
E
K
H
D
I
A
F
V
Y
Q
N
Y
S
---------
L
F
P
H
M
N
V
K
K
N
L
---
E
F
G
--
M
R
M
--
K
K
--
I
--
K
---
D
P
--
K
R
V
L
D
T
A
R
D
L
K
I
E
H
L
L
------
D
R
N
P
-----------
L
T
L
S
G
G
E
Q
Q
R
V
A
L
A
R
A
L
V
T
N
P
K
I
L
L
L
D
E
P
L
S
A
L
D
P
R
-
T
Q
E
N
A
R
E
M
L
S
V
L
H
-
K
K
N
-
K
L
-
T
V
L
H
I
T
H
D
Q
T
E
A
R
I
M
A
D
R
I
A
V
V
M
D
G
K
L
I
-----
Q
V
G
K
P
E
E
-----
I
---------------------------------------------------------------------------------------------------------------------------------
45
Fugue
66.81
24%
-19
- C1 -
1Z47
1
?
A:
[11-355]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G
S
M
T
I
E
F
V
G
V
E
K
I
Y
P
---
G
-
G
---
A
R
S
-
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
---
K
R
V
T
D
L
P
--
P
Q
K
-----
R
N
V
G
L
V
F
Q
N
Y
A
L
----------
F
Q
H
M
T
V
Y
D
N
V
---
S
F
G
--
L
R
E
K
R
V
P
--
K
--
D
--
E
M
D
--
A
R
V
R
E
L
L
R
F
M
R
L
E
S
Y
A
------
N
R
F
P
-----------
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
-
I
R
R
E
L
R
T
F
V
R
Q
V
H
-
D
-
E
M
G
V
-
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
-----
Q
F
G
T
P
E
E
-----
V
Y
E
KP
G
T
-----
L
F
V
A
S
F
I
G
E
S
N
V
W
T
R
A
V
Q
NG
R
I
E
V
AG
A
A
L
P
V
DPAVSEG
S
E
V
A
V
V
V
R
PKD
V
E
L
Q
P
A
S
EREAHAQVV
R
S
A
F
KGS
Y
S
A
C
W
I
R
T
KD
G
E
V
W
E
V
H
V
P
SADRHRWSPG
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R--
23
HHSearch
65.34
24%
-55
- C1 -
1Z47
1
?
A:
[13-234]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
I
E
F
V
G
V
E
K
I
Y
P
---
G
-
G
---
A
R
S
-
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
---
K
R
V
T
D
--------
L
P
P
Q
K
R
N
V
G
L
V
F
Q
N
Y
A
---------
L
F
Q
H
M
T
V
Y
D
N
V
---
S
F
G
--
L
R
E
--
K
R
--
V
P
K
D
--
E
M
D
--
A
R
V
R
E
L
L
R
F
M
R
L
E
S
Y
A
------
N
R
F
P
-----------
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
-
I
R
R
E
L
R
T
F
V
R
Q
V
H
-
D
E
M
-
G
V
-
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
-----
Q
F
G
T
P
E
E
-----
V
Y
--------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
61.26
20%
-68
- C1 -
4YER
4
?
A:
[3-253]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
I
I
V
V
E
N
L
V
K
K
F
G
---
D
-----
F
E
A
-
V
K
G
V
S
F
S
V
K
K
G
E
I
F
A
F
L
G
P
N
G
A
G
K
T
T
T
I
H
M
L
T
T
L
L
K
P
T
S
G
K
A
W
V
A
G
---
H
D
V
L
K
-------
E
P
R
E
V
R
R
K
I
G
I
V
F
Q
D
Q
S
---------
L
D
R
E
L
T
A
Y
E
N
M
---
Y
I
H
--
G
K
I
--
Y
G
--
Y
--
G
G
E
K
L
K
--
K
R
I
L
E
L
L
E
F
V
E
L
L
E
F
K
------
D
K
P
V
-----------
K
T
F
S
G
G
M
A
R
R
L
E
I
A
R
S
L
I
H
E
P
E
V
L
F
L
D
E
P
T
I
G
L
D
P
H
-
T
R
A
H
M
W
E
Y
I
S
K
M
K
-
K
E
H
-
N
M
-
T
I
F
L
T
T
H
Y
M
D
E
A
E
Q
L
A
D
R
V
A
I
I
D
H
G
K
I
I
-----
A
L
G
T
P
T
E
-----
L
K
--------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
58.21
24%
-11
- C1 -
2D62
7
?
A:
[10-224]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
I
W
K
R
---
F
-
G
---
D
V
T
A
V
K
D
L
S
L
E
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
R
G
Q
I
Y
I
E
D
NLV
A
D
P
E
K
G
V
F
V
P
P
K
E
R
D
V
A
M
V
F
Q
S
Y
A
--------------
L
Y
P
H
M
T
V
Y
D
N
I
---
A
F
P
--
L
K
L
--
R
K
VP
K
--
Q
--
E
I
D
--
K
R
V
R
E
V
A
E
M
L
G
L
T
E
L
L
------
N
R
K
P
-----------
R
E
L
S
G
G
Q
R
Q
R
V
A
L
G
R
A
I
I
R
R
P
K
V
F
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
K
M
R
A
E
L
K
K
L
Q
R
-
Q
-
L
-
G
V
-
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
K
G
E
L
Q
-----
Q
V
--------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
57.70
22%
-52
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[2-232]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
A
L
H
I
G
H
L
S
K
S
F
Q
---
N
-----
T
P
V
-
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
---
K
T
I
F
S
K
----
N
T
N
L
P
V
R
E
R
R
L
G
Y
L
V
Q
E
G
V
---------
L
F
P
H
L
T
V
Y
R
N
I
---
A
Y
G
--
L
G
N
--
G
K
--
G
RT
A
--
Q
E
R
--
Q
R
I
E
A
M
L
E
L
T
G
I
S
E
L
A
------
G
R
Y
P
-----------
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
-
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
-
N
-
G
K
-
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
-----
Q
T
A
S
P
H
E
-----
L
Y
--------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
57.53
24%
-44
- C1 -
3TUZ
1
METN_ECOLI
C:
[44-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
---
Q
E
L
T
T
-----
L
S
E
S
E
L
T
K
A
R
R
Q
I
G
M
I
F
Q
H
FN-------
L
L
S
S
R
T
V
F
G
N
V
---
A
L
P
--
L
E
L
DN
T
P
--
K
--
D
--
E
V
K
--
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
------
D
S
Y
P
-----------
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
-
T
T
R
S
I
L
E
L
L
K
D
I
N
-
R
-
R
-
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
-----
E
Q
D
T
V
S
E
VFSHP
K
T
P
--
L
A
-----
Q
K
F
I
Q
S
T
L
H
-------------------------------------------------------------------------------------------------------------
49
Fugue
57.25
23%
-36
- C1 -
1OXS
23
?
C:
[1-352]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
R
I
I
V
K
N
V
S
K
V
F
K
---
K
G
K
---
V
V
A
-
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
---
R
L
V
A
S
N
G
--
K
L
I
V
P
P
E
D
R
K
I
G
M
V
F
Q
T
W
A
L
----------
Y
P
N
L
T
A
F
E
N
I
---
A
F
P
LT
N
M
K
--
M
S
--
K
--
E
--
E
I
R
--
K
R
V
E
E
V
A
K
I
L
D
I
H
H
V
L
------
N
H
F
P
-----------
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
-
M
R
D
S
A
R
A
L
V
K
E
V
Q
-
S
-
R
L
G
V
-
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
-----
Q
V
---
G
K
-----
P
E
D
--
L
Y
DNPVS
I
Q
V
A
S
L
I
G
E
I
NELEGKVTNEGVVIGSLRFPVSVSSDRAIIGIRPEDVKLSKDVIKDDSWILVGKGKVKVIGYQGGLFRITITPLDSEEEIFTYSDHPIHSGEEVLVYVRKDKIKVFEK
44
Fugue
57.14
22%
-17
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
K
L
S
N
I
T
K
V
F
H
QGT
R
-
T
---
I
Q
A
-
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
---
Q
E
L
T
T
-
L
--
S
E
S
E
L
T
K
A
R
R
Q
I
G
M
I
F
Q
H
F
N
---------
L
L
S
S
R
T
V
F
G
N
V
---
A
L
P
--
L
E
L
DN
T
P
--
K
--
D
--
E
V
K
--
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
------
D
S
Y
P
-----------
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
-
T
T
R
S
I
L
E
L
L
K
D
I
N
-
R
-
R
-
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
EQDTV
S
E
V
F
S
H
P
-----
K
T
P
--
L
A
-----
Q
K
F
I
Q
S
T
L
H
L
DIPEDYQERLQAEPFTDCVPMLRLEFTGQSVDAPLLSETARRFNVNNNIISAQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEV----------------
16
PsiBlast_PDB
57.00
24%
-53
- C1 -
3TUJ
-
METN_ECOLI
C:
[21-246]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
---
Q
E
L
T
T
-----
L
S
E
S
E
L
T
K
A
R
R
Q
I
G
M
I
F
Q
H
FN-------
L
L
S
S
R
T
V
F
G
N
V
---
A
L
P
--
L
E
L
DN
T
P
--
K
--
D
--
E
V
K
--
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
------
D
S
Y
P
-----------
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
-
T
T
R
S
I
L
E
L
L
K
D
I
N
-
R
-
R
-
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
-----
E
Q
D
T
V
S
E
VFSHP
K
T
P
--
L
A
-----
Q
K
F
I
Q
S
T
L
H
-------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
56.74
24%
-45
- C1 -
3TUI
1
METN_ECOLI
C:
[44-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
---
Q
E
L
T
T
-----
L
S
E
S
E
L
T
K
A
R
R
Q
I
G
M
I
F
Q
H
FN-------
L
L
S
S
R
T
V
F
G
N
V
---
A
L
P
--
L
E
L
DN
T
P
--
K
--
D
--
E
V
K
--
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
------
D
S
Y
P
-----------
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
-
T
T
R
S
I
L
E
L
L
K
D
I
N
-
R
-
R
-
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
-----
E
Q
D
T
V
S
E
VFSHP
K
T
P
--
L
A
-----
Q
K
F
I
Q
S
T
L
H
-------------------------------------------------------------------------------------------------------------
31
HHSearch
56.53
22%
-29
* C1 *
3TUI
1
METN_ECOLI
C:
[23-251]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
K
L
S
N
I
T
K
V
F
H
---
Q
-
G
TRT
I
Q
A
-
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
---
Q
E
L
T
T
L
---
S
E
S
E
L
T
K
A
R
R
Q
I
G
M
I
F
Q
H
F
N
---------
L
L
S
S
R
T
V
F
G
N
V
---
A
L
P
--
L
E
L
--
D
N
--
T
PK
D
--
E
V
K
--
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
------
D
S
Y
P
-----------
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
-
T
T
R
S
I
L
E
L
L
K
D
I
N
-
R
R
L
-
G
L
-
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
-----
E
Q
D
T
V
S
E
-----
V
---------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
55.92
25%
-59
- C1 -
1G6H
3
LIVG_METJA
A:
[23-231]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
G
V
S
I
S
V
N
K
G
D
V
T
L
I
I
G
P
N
G
S
G
K
S
T
L
I
N
V
I
T
G
F
L
K
A
D
E
G
R
V
Y
F
E
N
---
K
D
I
T
N
K
E
--
P
A
E
L
Y
-
H
Y
G
I
V
R
T
F
Q
T
P
Q
P
L
K
E
M
T
V
L
E
N
L
L
I
G
E
I
C
P
G
E
-----
S
P
L
--
N
S
L
--
F
Y
--
K
--
K
--
W
I
P
--
K
E
E
E
M
V
E
K
A
F
K
I
L
E
F
L
KLSHLY
D
R
K
A
-----------
G
E
L
S
G
G
Q
M
K
L
V
E
I
G
R
A
L
M
T
N
P
K
M
I
V
M
D
E
P
I
A
G
V
A
P
G
-
L
A
H
D
I
F
N
H
V
L
E
L
K
-
A
-
K
-
G
I
-
T
F
L
I
I
E
H
R
L
D
I
V
L
N
Y
I
D
H
L
Y
V
M
F
N
G
Q
I
----------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
55.27
21%
2
- C1 -
3B60
2
MSBA_SALTY
A:
[10-581]
W
Q
T
F
R
R
L
W
P
T
I
A
PFK
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
LKPLLDDGFGKTDRSVLLW
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
MPVAFFDKQS
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
FYYS
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
KEVLIFGG
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
FPSVMDSLT
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
SEQEK
D
E
G
K
RVIDRA
T
G
D
L
E
F
R
N
V
T
F
T
Y
P
G--
R
-
E
---
V
P
A
-
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
---
H
D
----
L
--
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
---------
L
F
N
D
-
T
V
A
N
N
I
---
A
Y
A
--
R
T
-------
E
--
E
--
Y
S
R
--
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
------
N
K
M
D
NGLD
T
I
I
G
ENG
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
-
S
E
R
A
I
Q
A
A
L
D
E
L
Q
-
K
-
N
-
R
T
-
S
L
V
I
A
-
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
--------
I
I
V
E
R
G
T
-----
H
S
E
--
L
L
-----
A
Q
H
G
V
Y
A
Q
L
H
K
M
QFG-------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
54.03
25%
-51
- C1 -
1GAJ
6
LIVG_METJA
A:
[23-231]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
G
V
S
I
S
V
N
K
G
D
V
T
L
I
I
G
P
N
G
S
G
K
S
T
L
I
N
V
I
T
G
F
L
K
A
D
E
G
R
V
Y
F
E
N
---
K
D
I
T
N
K
E
--
P
A
E
L
Y
-
H
Y
G
I
V
R
T
F
Q
T
P
Q
P
L
K
E
MT
V
L
E
N
L
L
I
G
E
I
N
P
G
E
-----
S
P
L
--
N
S
L
--
F
Y
--
K
--
K
--
W
I
P
--
K
E
E
E
M
V
E
K
A
F
K
I
L
E
F
L
KLSHLY
D
R
K
A
-----------
G
E
L
S
G
G
Q
M
K
L
V
E
I
G
R
A
L
M
T
N
P
K
M
I
V
M
D
Q
P
I
A
G
V
A
P
G
-
L
A
H
D
I
F
N
H
V
L
E
L
K
-
A
-
K
-
G
I
-
T
F
L
I
I
E
H
R
L
D
I
V
L
N
Y
I
D
H
L
Y
V
M
F
N
G
Q
I
----------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
53.70
25%
-47
- C1 -
3DHW
-
METN_ECOLI
C:
[21-246]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
---
Q
E
L
T
T
-----
L
S
E
S
E
L
T
K
A
R
R
Q
I
G
M
I
F
Q
H
FN-------
L
L
S
S
R
T
V
F
G
N
V
---
A
L
P
--
L
E
L
DN
T
P
--
K
--
D
--
E
V
K
--
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
------
D
S
Y
P
-----------
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
E
A
T
S
A
L
D
P
A
-
T
T
R
S
I
L
E
L
L
K
D
I
N
-
R
-
R
-
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
-----
E
Q
D
T
V
S
E
VFSHP
K
T
P
--
L
A
-----
Q
K
F
I
Q
S
T
L
H
-------------------------------------------------------------------------------------------------------------