@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu37560: (2016-08-02 )
MSKHVHIQLPDGQIQEYPKGITIKEAAGSISSSLQKKAAAGQVNGKLVDLSFKLEEDAELSIVTLDSQEGLQVLRHTTAHVLAQAVKRLYGEVSLGVGPVILDGFYYDMKLGKSLASGDLEAIEKEMKNIINENLEIKRIEVSYEEAEELFAQKDERLKLEILKDIPRGEDITLYQQGEFVDLCRGPHLPSTGMIKAFKLTRVSGAYWRGDSKNEVLQRVYGVAFQKKKDLDAHLHMLEEAAKRDHRKLGKQLGLFMFSEEAPGMPFYLPKGQIVRNELERFSRELQTNAGYDEVRTPFMMNQRLWEQSGHWDHYRDNMYFSEVDDTRFAMKPMNCPGHMLIFKNSLYSYRDLPIRMAEFGQVHRHEYSGALNGMLRVRTFCQDDAHIFVREDQIESEIKEAIRLIDEVYRTFGFEYSVELSTRPEDSLGDDSLWEASERALARVLEELGLSYEINEGDGAFYGPKIDFHIKDALKRSHQCATIQLDFQMPEKFDLTYINELNEKVRPVVIHRAVFGSIDRFFGILIEHYGGAFPVWLAPIQVQIIPVSHVHLDYCRKVQAELKQAGIRAGIDERNEKLGYKIRESQVQKIPYVLVLGDHEEQENAVNVRRFGHQQNEHVPFQTFKDKLVKQVENRGM
Atome Classification :
(38 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.-.....-.170.......180.......190.......200.......210.......220.......230.......240.......250.......260........270.......280.....-.-.290.......300.......310.......320-..--....---.330.......340.......350.......360.......370.......380.......390.......400.......410.-...----.----...420..-..----..---.430.......440.......450.......460.......470.......480.......490.......500...-.....510.......520.......530.......540.......-550---.---.......560...--------------.--------------...570.-..-....580.......590.......600.......610.....-..620.......630......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
K
H
V
H
I
QLPD
G
Q
I
Q
EYPKG
I
T
I
K
E
A
A
G
S
I
S
S
S
L
Q
K
K
AAAGQVN
G
K
L
V
D
L
S
F
K
LEEDA
E
L
S
I
V
T
LD
S
Q
E
G
L
Q
V
L
R
H
T
T
A
H
V
L
A
Q
A
V
K
R
L
Y
G
EVSLGVG
P
V
I
LD
G
F
Y
Y
D
M
K
L
G
K
S
LASG
D
L
E
A
I
E
K
E
M
K
N
I
I
NEN
L
E
I
K
R
I
E
V
S
Y
E
E
A
E
E
L
F
A
QKDE
R
L
K
L
E
I
L
-
K
DIPR-GE
D
I
T
L
YQQG
E
F
V
D
LCRGPHLPSTG
M
I
K
A
F
K
L
T
RVS
G
A
Y
WRGD
S
K
N
E
V
L
Q
R
V
Y
G
V
AFQKKK
D
L
D
A
H
L
H
M
L
E
E
A
A
K
R
D
H
R
K
L
G
K
QL
G
L
F
M
FSE-EAPGM
P
F
YLPK
G
Q
I
V
R
N
E
L
E
R
F
S
R
E
L
Q-T-NAGYDEVR
T
P
F
M
M
N
Q
R
L
W
EQSGHWDHYRDNMYFS-EV--DDT
R
---
F
AMKPMNCPG
H
M
L
I
F
KNSLYSYRDLP
I
R
M
A
E
F
G
Q
V
H
R
H
E
Y
S
G
A
L
N
G
M
L
R
V
R
T
F
CQDD
A
H
I
F
V
R
E
D
Q
I
E
S
E
I
K
E
A
I
R
L
I
D
E
V
Y
-
R
T-FG
F
----
E
----
Y
S
V
E
LSTR-PE----DS---LGD
D
S
L
W
E
A
S
E
R
A
L
A
R
V
L
E
ELG
L
S
Y
E
INEGDGAFYG
P
K
I
D
F
H
I
K
D
A
L
KRSH
Q
C
A
T
I
Q
L
D
FQMPEKF
D
L
T
Y
I
N
-
E
L
NE-KV
R
P
V
V
I
H
R
A
V
F
G
S
I
D
R
F
F
G
I
L
I
E
HYGGAF
P
V
W
L
A
P
I
Q
V
Q
I
I
P
VS-H-V---
H
---
L
D
Y
C
R
K
V
Q
A
E
L
K
Q
--------------
A
--------------
G
IRAGI
D
-
E
R
-
N
E
KLGY
K
I
R
E
S
Q
V
QKI
P
Y
V
L
V
LGDHEEQENA
V
N
V
R
R
FGHQQN-EHV
P
F
Q
T
F
K
D
K
L
V
K
Q
V
E
NRGM
71
HHSearch
84.85
52%
-16
- C2 -
1NYR
4
SYT_STAAW
A:
[4-642]
----
I
N
I
Q
F
P
D
G
N
K
K
A
F
D
K
G
T
T
T
E
D
I
A
Q
S
I
S
P
G
L
R
K
K
A
V
A
G
K
F
N
G
Q
L
V
D
L
T
K
P
L
E
T
D
G
S
I
E
I
V
T
P
G
S
E
E
A
L
E
V
L
R
H
S
T
A
H
L
M
A
H
A
I
K
R
L
Y
G
N
V
K
F
G
V
G
P
V
I
E
G
G
F
Y
Y
D
F
D
I
D
Q
N
I
S
S
D
D
F
E
Q
I
E
K
T
M
K
Q
I
V
N
E
N
M
K
I
E
R
K
V
V
S
R
D
E
A
K
E
L
F
S
N
--
D
E
Y
K
L
E
L
I
-
D
A
I
P
E
-
D
E
N
V
T
L
Y
S
Q
G
D
F
T
D
L
C
R
G
V
H
V
P
S
T
A
K
I
K
E
F
K
L
L
S
T
A
G
A
Y
W
R
G
D
S
N
N
K
M
L
Q
R
I
Y
G
T
A
F
F
D
K
K
E
L
K
A
H
L
Q
M
L
E
E
R
K
E
R
D
H
R
K
I
G
K
E
L
E
L
F
T
N
S
Q
L
V
G
A
G
L
P
L
W
L
P
N
G
A
T
I
R
R
E
I
E
R
Y
I
V
D
K
E
-
V
-
S
M
G
Y
D
H
V
Y
T
P
V
L
A
N
V
D
L
Y
K
T
S
G
H
W
D
H
Y
Q
E
D
M
F
P
P
-
M
Q
LD
E
T
E
S
---
M
V
L
R
P
M
N
C
P
H
H
M
M
I
Y
A
N
K
P
H
S
Y
R
E
L
P
I
R
I
A
E
L
G
T
M
H
R
Y
E
A
S
G
A
V
S
G
L
Q
R
V
R
G
M
T
L
N
D
S
H
I
F
V
R
P
D
Q
I
K
E
E
F
K
R
V
V
N
M
I
I
D
V
Y
-
K
D
-
F
G
F
----
E
D
---
Y
S
F
R
L
S
Y
R
-
D
P
EDKE
K
Y
---
F
D
D
D
D
M
W
N
K
A
E
N
M
L
K
E
A
A
D
E
L
G
L
S
Y
E
E
A
I
G
E
A
A
F
Y
G
P
K
L
D
V
Q
V
K
T
A
M
G
K
E
E
T
L
S
T
A
Q
L
D
F
L
L
P
E
R
F
D
L
T
Y
I
G
-
Q
D
G
E
-
H
H
R
P
V
V
I
H
R
G
V
V
S
T
M
E
R
F
V
A
F
L
T
E
E
T
K
G
A
F
P
T
W
L
A
P
K
Q
V
Q
I
I
P
V
N
-
V
D
L
---
H
---
Y
D
Y
A
R
Q
L
Q
D
E
L
K
S
--------------
Q
--------------
G
V
R
V
S
I
D
-
D
R
-
N
E
K
M
G
Y
K
I
R
E
A
Q
M
Q
K
I
P
Y
Q
I
V
V
G
D
K
E
V
E
N
N
Q
V
N
V
R
Q
Y
G
S
Q
D
Q
-
E
T
V
E
K
D
E
F
I
W
N
L
V
D
E
I
R
L
K
--
2
PsiBlast_PDB
83.76
51%
-15
- C2 -
1NYR
4
SYT_STAAW
A:
[4-639]
----
I
N
I
Q
F
P
D
G
N
K
K
A
F
D
K
G
T
T
T
E
D
I
A
Q
S
I
S
P
G
L
R
K
K
A
V
A
G
K
F
N
G
Q
L
V
D
L
T
K
P
L
E
T
D
G
S
I
E
I
V
T
P
G
S
E
E
A
L
E
V
L
R
H
S
T
A
H
L
M
A
H
A
I
K
R
L
Y
G
N
V
K
F
G
V
G
P
V
I
E
G
G
F
Y
Y
D
F
D
I
D
Q
N
I
S
S
D
D
F
E
Q
I
E
K
T
M
K
Q
I
V
N
E
N
M
K
I
E
R
K
V
V
S
R
D
E
A
K
E
L
F
S
--
N
D
E
Y
K
L
E
L
I
-
D
A
I
P
E
-
D
E
N
V
T
L
Y
S
Q
G
D
F
T
D
L
C
R
G
V
H
V
P
S
T
A
K
I
K
E
F
K
L
L
S
T
A
G
A
Y
W
R
G
D
S
N
N
K
M
L
Q
R
I
Y
G
T
A
F
F
D
K
K
E
L
K
A
H
L
Q
M
L
E
E
R
K
E
R
D
H
R
K
I
G
K
E
L
E
L
F
T
N
S
Q
L
V
G
A
G
L
P
L
W
L
P
N
G
A
T
I
R
R
E
I
E
R
Y
I
V
D
K
E
-
V
-
S
M
G
Y
D
H
V
Y
T
P
V
L
A
N
V
D
L
Y
K
T
S
G
H
W
D
H
Y
Q
E
D
M
F
P
P
M
Q
L
--
D
E
T
E
S
--
M
V
L
R
P
M
N
C
P
H
H
M
M
I
Y
A
N
K
P
H
S
Y
R
E
L
P
I
R
I
A
E
L
G
T
M
H
R
Y
E
A
S
G
A
V
S
G
L
Q
R
V
R
G
M
T
L
N
D
S
H
I
F
V
R
P
D
Q
I
K
E
E
F
K
R
V
V
N
M
I
I
D
V
Y
-
K
D
-
F
G
F
----
E
D
---
Y
S
F
R
L
S
Y
R
D
P
E
----
D
K
EKY
F
D
D
D
D
M
W
N
K
A
E
N
M
L
K
E
A
A
D
E
L
G
L
S
Y
E
E
A
I
G
E
A
A
F
Y
G
P
K
L
D
V
Q
V
K
T
A
M
G
K
E
E
T
L
S
T
A
Q
L
D
F
L
L
P
E
R
F
D
L
T
Y
I
G
-
Q
D
G
E
-
H
H
R
P
V
V
I
H
R
G
V
V
S
T
M
E
R
F
V
A
F
L
T
E
E
T
K
G
A
F
P
T
W
L
A
P
K
Q
V
Q
I
I
P
V
N
V
D
-
L
---
H
---
Y
D
Y
A
R
Q
L
Q
D
E
L
K
S
--------------
Q
--------------
G
V
R
V
S
I
D
-
D
R
-
N
E
K
M
G
Y
K
I
R
E
A
Q
M
Q
K
I
P
Y
Q
I
V
V
G
D
K
E
V
E
N
N
Q
V
N
V
R
Q
Y
G
S
Q
D
Q
-
E
T
V
E
K
D
E
F
I
W
N
L
V
D
E
I
-----
70
HHSearch
83.61
46%
-28
- C2 -
1QF6
2
SYT_ECOLI
A:
[2-636]
----
P
V
I
T
L
P
D
G
S
Q
R
H
Y
D
H
A
V
S
P
M
D
V
A
L
D
I
G
P
G
L
A
K
A
C
I
A
G
R
V
N
G
E
L
V
D
A
C
D
L
I
E
N
D
A
Q
L
S
I
I
T
A
K
D
E
E
G
L
E
I
I
R
H
S
C
A
H
L
L
G
H
A
I
K
Q
L
W
P
H
T
K
M
A
I
G
P
V
I
D
N
G
F
Y
Y
D
V
D
L
D
R
T
L
T
Q
E
D
V
E
A
L
E
K
R
M
H
E
L
A
E
K
N
Y
D
V
I
K
K
K
V
S
W
H
E
A
R
E
T
F
A
N
R
G
E
S
Y
K
V
S
I
L
-
D
E
N
I
A
H
D
D
K
P
G
L
Y
F
H
E
E
Y
V
D
M
C
R
G
P
H
V
P
N
M
R
F
C
H
H
F
K
L
M
K
T
A
G
A
Y
W
R
G
D
S
N
N
K
M
L
Q
R
I
Y
G
T
A
W
A
D
K
K
A
L
N
A
Y
L
Q
R
L
E
E
A
A
K
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
-
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
-
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
T
-
S
S
--
E
N
R
E
---
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K
---
I
V
V
K
L
S
T
R
-
P
E
----
K
R
---
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
-
E
D
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
-
S
---
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
-
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
S
-
1
PsiBlast_PDB
83.50
51%
-17
- C2 -
1NYQ
2
SYT_STAAW
A:
[4-639]
----
I
N
I
Q
F
P
D
G
N
K
K
A
F
D
K
G
T
T
T
E
D
I
A
Q
S
I
S
P
G
L
R
K
K
A
V
A
G
K
F
N
G
Q
L
V
D
L
T
K
P
L
E
T
D
G
S
I
E
I
V
T
P
G
S
E
E
A
L
E
V
L
R
H
S
T
A
H
L
M
A
H
A
I
K
R
L
Y
G
N
V
K
F
G
V
G
P
V
I
E
G
G
F
Y
Y
D
F
D
I
D
Q
N
I
S
S
D
D
F
E
Q
I
E
K
T
M
K
Q
I
V
N
E
N
M
K
I
E
R
K
V
V
S
R
D
E
A
K
E
L
F
S
--
N
D
E
Y
K
L
E
L
I
-
D
A
I
P
E
-
D
E
N
V
T
L
Y
S
Q
G
D
F
T
D
L
C
R
G
V
H
V
P
S
T
A
K
I
K
E
F
K
L
L
S
T
A
G
A
Y
W
R
G
D
S
N
N
K
M
L
Q
R
I
Y
G
T
A
F
F
D
K
K
E
L
K
A
H
L
Q
M
L
E
E
R
K
E
R
D
H
R
K
I
G
K
E
L
E
L
F
T
N
S
Q
L
V
G
A
G
L
P
L
W
L
P
N
G
A
T
I
R
R
E
I
E
R
Y
I
V
D
K
E
-
V
-
S
M
G
Y
D
H
V
Y
T
P
V
L
A
N
V
D
L
Y
K
T
S
G
H
W
D
H
Y
Q
E
D
M
F
P
P
M
Q
L
--
D
E
T
E
S
--
M
V
L
R
P
M
N
C
P
H
H
M
M
I
Y
A
N
K
P
H
S
Y
R
E
L
P
I
R
I
A
E
L
G
T
M
H
R
Y
E
A
S
G
A
V
S
G
L
Q
R
V
R
G
M
T
L
N
D
S
H
I
F
V
R
P
D
Q
I
K
E
E
F
K
R
V
V
N
M
I
I
D
V
Y
-
K
D
-
F
G
F
----
E
D
---
Y
S
F
R
L
S
Y
R
D
P
E
----
D
K
EKY
F
D
D
D
D
M
W
N
K
A
E
N
M
L
K
E
A
A
D
E
L
G
L
S
Y
E
E
A
I
G
E
A
A
F
Y
G
P
K
L
D
V
Q
V
K
T
A
M
G
K
E
E
T
L
S
T
A
Q
L
D
F
L
L
P
E
R
F
D
L
T
Y
I
G
-
Q
D
G
E
-
H
H
R
P
V
V
I
H
R
G
V
V
S
T
M
E
R
F
V
A
F
L
T
E
E
T
K
G
A
F
P
T
W
L
A
P
K
Q
V
Q
I
I
P
V
N
V
D
-
L
---
H
---
Y
D
Y
A
R
Q
L
Q
D
E
L
K
S
--------------
Q
--------------
G
V
R
V
S
I
D
-
D
R
-
N
E
K
M
G
Y
K
I
R
E
A
Q
M
Q
K
I
P
Y
Q
I
V
V
G
D
K
E
V
E
N
N
Q
V
N
V
R
Q
Y
G
S
Q
D
Q
-
E
T
V
E
K
D
E
F
I
W
N
L
V
D
E
I
-----
3
PsiBlast_PDB
82.91
48%
-33
- C1 -
1QF6
2
SYT_ECOLI
A:
[4-609]
------
I
T
L
P
D
G
S
Q
R
H
Y
D
H
A
V
S
P
M
D
V
A
L
D
I
G
P
G
L
A
K
A
C
I
A
G
R
V
N
G
E
L
V
D
A
C
D
L
I
E
N
D
A
Q
L
S
I
I
T
A
K
D
E
E
G
L
E
I
I
R
H
S
C
A
H
L
L
G
H
A
I
K
Q
L
W
P
H
T
K
M
A
I
G
P
V
I
D
N
G
F
Y
Y
D
V
D
L
D
R
T
L
T
Q
E
D
V
E
A
L
E
K
R
M
H
E
L
A
E
K
N
Y
D
V
I
K
K
K
V
S
W
H
E
A
R
E
T
F
A
N
R
G
E
S
Y
K
V
S
I
L
D
E
N
I
A
H
-
D
D
K
P
G
L
Y
F
H
E
E
Y
V
D
M
C
R
G
P
H
V
P
N
M
R
F
C
H
H
F
K
L
M
K
T
A
G
A
Y
W
R
G
D
S
N
N
K
M
L
Q
R
I
Y
G
T
A
W
A
D
K
K
A
L
N
A
Y
L
Q
R
L
E
E
A
A
K
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
-
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
-
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
T
-
S
S
--
E
N
R
E
---
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K
---
I
V
V
K
L
S
T
R
-
P
E
----
K
R
---
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
-
E
D
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
-
S
---
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
-
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
-----------------------------
22
PsiBlast_CBE
80.76
51%
-13
- C2 -
1NYQ
2
SYT_STAAW
B:
[2-639]
--
E
Q
I
N
I
Q
F
P
D
G
N
K
K
A
F
D
K
G
T
T
T
E
D
I
A
Q
S
I
S
P
G
L
R
K
K
A
V
A
G
K
F
N
G
Q
L
V
D
L
T
K
P
L
E
T
D
G
S
I
E
I
V
T
P
G
S
E
E
A
L
E
V
L
R
H
S
T
A
H
L
M
A
H
A
I
K
R
L
Y
G
N
V
K
F
G
V
G
P
V
I
E
G
G
F
Y
Y
D
F
D
I
D
Q
N
I
S
S
D
D
F
E
Q
I
E
K
T
M
K
Q
I
V
N
E
N
M
K
I
E
R
K
V
V
S
R
D
E
A
K
E
L
F
S
--
N
D
E
Y
K
L
E
L
I
-
D
A
I
P
E
-
D
E
N
V
T
L
Y
S
Q
G
D
F
T
D
L
C
R
G
V
H
V
P
S
T
A
K
I
K
E
F
K
L
L
S
T
A
G
A
Y
W
R
G
D
S
N
N
K
M
L
Q
R
I
Y
G
T
A
F
F
D
K
K
E
L
K
A
H
L
Q
M
L
E
E
R
K
E
R
D
H
R
K
I
G
K
E
L
E
L
F
T
N
S
Q
L
V
G
A
G
L
P
L
W
L
P
N
G
A
T
I
R
R
E
I
E
R
Y
I
V
D
K
E
-
V
-
S
M
G
Y
D
H
V
Y
T
P
V
L
A
N
V
D
L
Y
K
T
S
G
H
W
D
H
Y
Q
E
D
M
F
P
P
M
Q
L
--
D
E
T
E
S
--
M
V
L
R
P
M
N
C
P
H
H
M
M
I
Y
A
N
K
P
H
S
Y
R
E
L
P
I
R
I
A
E
L
G
T
M
H
R
Y
E
A
S
G
A
V
S
G
L
Q
R
V
R
G
M
T
L
N
D
S
H
I
F
V
R
P
D
Q
I
K
E
E
F
K
R
V
V
N
M
I
I
D
V
Y
-
K
D
-
F
G
F
----
E
D---
Y
S
F
R
L
S
Y
R
D
P
E
----
D
K
EKY
F
D
D
D
D
M
W
N
K
A
E
N
M
L
K
E
A
A
D
E
L
G
L
S
Y
E
E
A
I
G
E
A
A
F
Y
G
P
K
L
D
V
Q
V
K
T
A
M
G
K
E
E
T
L
S
T
A
Q
L
D
F
L
L
P
E
R
F
D
L
T
Y
I
G
-
Q
D
G
E
-
H
H
R
P
V
V
I
H
R
G
V
V
S
T
M
E
R
F
V
A
F
L
T
E
E
T
K
G
A
F
P
T
W
L
A
P
K
Q
V
Q
I
I
P
V
N
V
D
-
L
---
H
---
Y
D
Y
A
R
Q
L
Q
D
E
L
K
S
--------------
Q
--------------
G
V
R
V
S
I
D
-
D
R
-
N
E
K
M
G
Y
K
I
R
E
A
Q
M
Q
K
I
P
Y
Q
I
V
V
G
D
K
E
V
E
N
N
Q
V
N
V
R
Q
Y
G
S
Q
D
Q
-
E
T
V
E
K
D
E
F
I
W
N
L
V
D
E
I
-----
21
PsiBlast_CBE
80.25
51%
-11
- C2 -
1NYR
3
SYT_STAAW
B:
[2-639]
--
E
Q
I
N
I
Q
F
P
D
G
N
K
K
A
F
D
K
G
T
T
T
E
D
I
A
Q
S
I
S
P
G
L
R
K
K
A
V
A
G
K
F
N
G
Q
L
V
D
L
T
K
P
L
E
T
D
G
S
I
E
I
V
T
P
G
S
E
E
A
L
E
V
L
R
H
S
T
A
H
L
M
A
H
A
I
K
R
L
Y
G
N
V
K
F
G
V
G
P
V
I
E
G
G
F
Y
Y
D
F
D
I
D
Q
N
I
S
S
D
D
F
E
Q
I
E
K
T
M
K
Q
I
V
N
E
N
M
K
I
E
R
K
V
V
S
R
D
E
A
K
E
L
----------
E
L
I
-
D
A
I
P
E
-
D
E
N
V
T
L
Y
S
Q
G
D
F
T
D
L
C
R
G
V
H
V
P
S
T
A
K
I
K
E
F
K
L
L
S
T
A
G
A
Y
W
R
G
D
S
N
N
K
M
L
Q
R
I
Y
G
T
A
F
F
D
K
K
E
L
K
A
H
L
Q
M
L
E
E
R
K
E
R
D
H
R
K
I
G
K
E
L
E
L
F
T
N
S
Q
L
V
G
A
G
L
P
L
W
L
P
N
G
A
T
I
R
R
E
I
E
R
Y
I
V
D
K
E
-
V
-
S
M
G
Y
D
H
V
Y
T
P
V
L
A
N
V
D
L
Y
K
T
S
G
H
W
D
H
Y
Q
E
D
M
F
P
P
M
Q
L
--
D
E
T
E
S
--
M
V
L
R
P
M
N
C
P
H
H
M
M
I
Y
A
N
K
P
H
S
Y
R
E
L
P
I
R
I
A
E
L
G
T
M
H
R
Y
E
A
S
G
A
V
S
G
L
Q
R
V
R
G
M
T
L
N
D
S
H
I
F
V
R
P
D
Q
I
K
E
E
F
K
R
V
V
N
M
I
I
D
V
Y
-
K
D
-
F
G
F
----
E
D---
Y
S
F
R
L
S
Y
R
D
P
E
----
D
K
EKY
F
D
D
D
D
M
W
N
K
A
E
N
M
L
K
E
A
A
D
E
L
G
L
S
Y
E
E
A
I
G
E
A
A
F
Y
G
P
K
L
D
V
Q
V
K
T
A
M
G
K
E
E
T
L
S
T
A
Q
L
D
F
L
L
P
E
R
F
D
L
T
Y
I
G
-
Q
D
G
E
-
H
H
R
P
V
V
I
H
R
G
V
V
S
T
M
E
R
F
V
A
F
L
T
E
E
T
K
G
A
F
P
T
W
L
A
P
K
Q
V
Q
I
I
P
V
N
V
D
-
L
---
H
---
Y
D
Y
A
R
Q
L
Q
D
E
L
K
S
--------------
Q
--------------
G
V
R
V
S
I
D
-
D
R
-
N
E
K
M
G
Y
K
I
R
E
A
Q
M
Q
K
I
P
Y
Q
I
V
V
G
D
K
E
V
E
N
N
Q
V
N
V
R
Q
Y
G
S
Q
D
Q
-
E
T
V
E
K
D
E
F
I
W
N
L
V
D
E
I
-----
14
PsiBlast_PDB
68.68
49%
-104
- C2 -
4HWT
2
SYTC_HUMAN
A:
[3-371]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
R
D
Q
E
L
Y
F
F
H
E
-
L
S
P
G
S
C
F
F
L
P
K
G
A
Y
I
Y
N
A
L
I
E
F
I
R
S
E
Y
-
R
-
K
R
G
F
Q
E
V
V
T
P
N
I
F
N
S
R
L
W
M
T
S
G
H
W
Q
H
Y
S
E
N
M
F
S
F
-
E
V
--
E
K
E
L
---
F
A
L
K
P
M
N
C
P
G
H
C
L
M
F
D
H
R
P
R
S
W
R
E
L
P
L
R
L
A
D
F
G
V
L
H
R
N
E
L
S
G
A
L
T
G
L
T
R
V
R
R
F
Q
Q
D
D
A
H
I
F
C
A
M
E
Q
I
E
D
E
I
K
G
C
L
D
F
L
R
T
V
Y
-
S
V
-
F
G
F
----
S
----
F
K
L
N
L
S
T
R
-
P
E
----
K
F
---
L
G
D
I
E
V
W
D
Q
A
E
K
Q
L
E
N
S
L
N
E
F
G
E
K
W
E
L
N
S
G
D
G
A
F
Y
G
P
K
I
D
I
Q
I
K
D
A
I
G
R
Y
H
Q
C
A
T
I
Q
L
D
F
Q
L
P
I
R
F
N
L
T
Y
V
S
----
D
-
K
K
R
P
V
I
V
H
R
A
I
L
G
S
V
E
R
M
I
A
I
L
T
E
N
Y
G
G
K
W
P
F
W
L
S
P
R
Q
V
M
V
V
P
V
G
-
P
-
T
---
C
---
D
E
Y
A
Q
K
V
R
Q
Q
F
H
D
--------------
A
--------------
K
F
M
A
D
I
D
L
D
P
-
G
C
T
L
N
K
K
I
R
N
A
Q
L
A
Q
Y
N
F
I
L
V
V
G
E
K
E
K
I
S
G
T
V
N
I
R
-----------------------------
15
PsiBlast_PDB
68.61
48%
-83
- C2 -
4P3N
2
SYTC_HUMAN
A:
[14-381]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
R
K
I
G
R
D
Q
E
L
Y
F
F
H
E
-
L
S
P
G
S
C
F
F
L
P
K
G
A
Y
I
Y
N
A
L
I
E
F
I
R
S
E
Y
-
R
-
K
R
G
F
Q
E
V
V
T
P
N
I
F
N
S
R
L
W
M
T
S
G
H
W
Q
H
Y
S
E
N
M
F
S
F
-
E
V
--
E
K
E
L
---
F
A
L
K
P
M
N
C
P
G
H
C
L
M
F
D
H
R
P
R
S
W
R
E
L
P
L
R
L
A
D
F
G
V
L
H
R
N
E
L
S
G
A
L
T
G
L
T
R
V
R
R
F
Q
Q
D
D
A
H
I
F
C
A
M
E
Q
I
E
D
E
I
K
G
C
L
D
F
L
R
T
V
Y
-
S
V
-
F
G
F
----
S
----
F
K
L
N
L
S
T
R
-
P
E
----
K
F
---
L
G
D
I
E
V
W
D
Q
A
E
K
Q
L
E
N
S
L
N
E
F
G
E
K
W
E
L
N
S
G
D
G
A
F
Y
G
P
K
I
D
I
Q
I
K
D
A
I
G
R
Y
H
Q
C
A
T
I
Q
L
D
F
Q
L
P
I
R
F
N
L
T
Y
V
S
H
D
G
D
D
-
K
K
R
P
V
I
V
H
R
A
I
L
G
S
V
E
R
M
I
A
I
L
T
E
N
Y
G
G
K
W
P
F
W
L
S
P
R
Q
V
M
V
V
P
V
G
-
P
-
T
---
C
---
D
E
Y
A
Q
K
V
R
Q
Q
F
H
D
--------------
A
--------------
K
F
M
A
D
I
D
L
D
P
-
G
C
T
L
N
K
K
I
R
N
A
Q
L
A
Q
Y
N
F
I
L
V
V
G
E
K
E
K
I
S
G
T
V
N
I
R
-----------------------------
75
HHSearch
67.92
47%
-73
- C2 -
4HWT
2
SYTC_HUMAN
A:
[3-397]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
R
D
Q
E
L
Y
F
F
H
E
-
L
S
P
G
S
C
F
F
L
P
K
G
A
Y
I
Y
N
A
L
I
E
F
I
R
S
E
Y
-
R
-
K
R
G
F
Q
E
V
V
T
P
N
I
F
N
S
R
L
W
M
T
S
G
H
W
Q
H
Y
S
E
N
M
F
S
F
-
E
V
--
E
K
E
L
---
F
A
L
K
P
M
N
C
P
G
H
C
L
M
F
D
H
R
P
R
S
W
R
E
L
P
L
R
L
A
D
F
G
V
L
H
R
N
E
L
S
G
A
L
T
G
L
T
R
V
R
R
F
Q
Q
D
D
A
H
I
F
C
A
M
E
Q
I
E
D
E
I
K
G
C
L
D
F
L
R
T
V
Y
-
S
V
-
F
G
F
----
S
----
F
K
L
N
L
S
T
R
-
P
E
----
K
F
---
L
G
D
I
E
V
W
D
Q
A
E
K
Q
L
E
N
S
L
N
E
F
G
E
K
W
E
L
N
S
G
D
G
A
F
Y
G
P
K
I
D
I
Q
I
K
D
A
I
G
R
Y
H
Q
C
A
T
I
Q
L
D
F
Q
L
P
I
R
F
N
L
T
Y
V
S
-----D
K
K
R
P
V
I
V
H
R
A
I
L
G
S
V
E
R
M
I
A
I
L
T
E
N
Y
G
G
K
W
P
F
W
L
S
P
R
Q
V
M
V
V
P
V
G
-
P
-
T
---
C
---
D
E
Y
A
Q
K
V
R
Q
Q
F
H
D
--------------
A
--------------
K
F
M
A
D
I
D
-
L
D
P
G
C
T
L
N
K
K
I
R
N
A
Q
L
A
Q
Y
N
F
I
L
V
V
G
E
K
E
K
I
S
G
T
V
N
I
R
T
R
D
N
K
V
H
-
G
E
R
T
I
S
E
T
I
E
R
L
Q
Q
L
K
E
F
R
--
72
HHSearch
67.48
48%
-46
* C2 *
1EVL
2
SYT_ECOLI
A:
[1-394]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
-
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
-
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
T
-
S
S
--
E
N
R
E
---
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K
---
I
V
V
K
L
S
T
R
-
P
E
----
K
R
---
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
-
E
D
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
-
S
---
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
-
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
T
R
R
G
K
D
L
-
G
S
M
D
V
N
E
V
I
E
K
L
Q
Q
E
I
R
S
R
--
42
PsiBlast_CBE
67.46
48%
-83
- C2 -
4P3N
2
SYTC_HUMAN
D:
[14-381]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
R
K
I
G
R
D
Q
E
L
Y
F
F
H
E
-
L
S
P
G
S
C
F
F
L
P
K
G
A
Y
I
Y
N
A
L
I
E
F
I
R
S
E
Y
-
R
-
K
R
G
F
Q
E
V
V
T
P
N
I
F
N
S
R
L
W
M
T
S
G
H
W
Q
H
Y
S
E
N
M
F
S
F
-
E
V
--
E
K
E
L
---
F
A
L
K
P
M
N
C
P
G
H
C
L
M
F
D
H
R
P
R
S
W
R
E
L
P
L
R
L
A
D
F
G
V
L
H
R
N
E
L
S
G
A
L
T
G
L
T
R
V
R
R
F
Q
Q
D
D
A
H
I
F
C
A
M
E
Q
I
E
D
E
I
K
G
C
L
D
F
L
R
T
V
Y
-
S
V
-
F
G
F
----
S
----
F
K
L
N
L
S
T
R
-
P
E
----
K
F
---
L
G
D
I
E
V
W
D
Q
A
E
K
Q
L
E
N
S
L
N
E
F
G
E
K
W
E
L
N
S
G
D
G
A
F
Y
G
P
K
I
D
I
Q
I
K
D
A
I
G
R
Y
H
Q
C
A
T
I
Q
L
D
F
Q
L
P
I
R
F
N
L
T
Y
V
S
H
D
G
D
D
-
K
K
R
P
V
I
V
H
R
A
I
L
G
S
V
E
R
M
I
A
I
L
T
E
N
Y
G
G
K
W
P
F
W
L
S
P
R
Q
V
M
V
V
P
V
G
-
P
-
T
---
C
---
D
E
Y
A
Q
K
V
R
Q
Q
F
H
D
--------------
A
--------------
K
F
M
A
D
I
D
L
D
P
-
G
C
T
L
N
K
K
I
R
N
A
Q
L
A
Q
Y
N
F
I
L
V
V
G
E
K
E
K
I
S
G
T
V
N
I
R
-----------------------------
41
PsiBlast_CBE
67.43
49%
-80
- C2 -
4HWT
2
SYTC_HUMAN
B:
[3-371]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
R
D
Q
E
L
Y
F
F
H
E
-
L
S
P
G
S
C
F
F
L
P
K
G
A
Y
I
Y
N
A
L
I
E
F
I
R
S
E
Y
-
R
-
K
R
G
F
Q
E
V
V
T
P
N
I
F
N
S
R
L
W
M
T
S
G
H
W
Q
H
Y
S
E
N
M
F
S
F
-
E
V
--
E
K
E
L
---
F
A
L
K
P
M
N
C
P
G
H
C
L
M
F
D
H
R
P
R
S
W
R
E
L
P
L
R
L
A
D
F
G
V
L
H
R
N
E
L
S
G
A
L
T
G
L
T
R
V
R
R
F
Q
Q
D
D
A
H
I
F
C
A
M
E
Q
I
E
D
E
I
K
G
C
L
D
F
L
R
T
V
Y
-
S
V
-
F
G
F
----
S
----
F
K
L
N
L
S
T
R
-
P
E
----
K
F
---
L
G
D
I
E
V
W
D
Q
A
E
K
Q
L
E
N
S
L
N
E
F
G
E
K
W
E
L
N
S
G
D
G
A
F
Y
G
P
K
I
D
I
Q
I
K
D
A
I
G
R
Y
H
Q
C
A
T
I
Q
L
D
F
Q
L
P
I
R
F
N
L
T
Y
V
S
H
D
G
D
D
-
K
K
R
P
V
I
V
H
R
A
I
L
G
S
V
E
R
M
I
A
I
L
T
E
N
Y
G
G
K
W
P
F
W
L
S
P
R
Q
V
M
V
V
P
V
G
-
P
-
T
---
C
---
D
E
Y
A
Q
K
V
R
Q
Q
F
H
D
--------------
A
--------------
K
F
M
A
D
I
D
L
D
P
-
G
C
T
L
N
K
K
I
R
N
A
Q
L
A
Q
Y
N
F
I
L
V
V
G
E
K
E
K
I
S
G
T
V
N
I
R
-----------------------------
44
PsiBlast_CBE
66.71
48%
-78
- C2 -
4P3N
2
SYTC_HUMAN
B:
[14-381]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
R
K
I
G
R
D
Q
E
L
Y
F
F
H
E
-
L
S
P
G
S
C
F
F
L
P
K
G
A
Y
I
Y
N
A
L
I
E
F
I
R
S
E
Y
-
R
-
K
R
G
F
Q
E
V
V
T
P
N
I
F
N
S
R
L
W
M
T
S
G
H
W
Q
H
Y
S
E
N
M
F
S
F
-
E
V
--
E
K
E
L
---
F
A
L
K
P
M
N
C
P
G
H
C
L
M
F
D
H
R
P
R
S
W
R
E
L
P
L
R
L
A
D
F
G
V
L
H
R
N
E
L
S
G
A
L
T
G
L
T
R
V
R
R
F
Q
Q
D
D
A
H
I
F
C
A
M
E
Q
I
E
D
E
I
K
G
C
L
D
F
L
R
T
V
Y
-
S
V
-
F
G
F
----
S
----
F
K
L
N
L
S
T
R
-
P
E
----
K
F
---
L
G
D
I
E
V
W
D
Q
A
E
K
Q
L
E
N
S
L
N
E
F
G
E
K
W
E
L
N
S
G
D
G
A
F
Y
G
P
K
I
D
I
Q
I
K
D
A
I
G
R
Y
H
Q
C
A
T
I
Q
L
D
F
Q
L
P
I
R
F
N
L
T
Y
V
S
H
D
G
D
D
-
K
K
R
P
V
I
V
H
R
A
I
L
G
S
V
E
R
M
I
A
I
L
T
E
N
Y
G
G
K
W
P
F
W
L
S
P
R
Q
V
M
V
V
P
V
G
-
P
-
T
---
C
---
D
E
Y
A
Q
K
V
R
Q
Q
F
H
D
--------------
A
--------------
K
F
M
A
D
I
D
L
D
P
-
G
C
T
L
N
K
K
I
R
N
A
Q
L
A
Q
Y
N
F
I
L
V
V
G
E
K
E
K
I
S
G
T
V
N
I
R
-----------------------------
47
PsiBlast_CBE
66.49
48%
-83
- C2 -
4TTV
2
SYTC_HUMAN
B:
[15-380]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
I
G
R
D
Q
E
L
Y
F
F
H
E
-
L
S
P
G
S
C
F
F
L
P
K
G
A
Y
I
Y
N
A
L
I
E
F
I
R
S
E
Y
-
R
-
K
R
G
F
Q
E
V
V
T
P
N
I
F
N
S
R
L
W
M
T
S
G
H
W
Q
H
Y
S
E
N
M
F
S
F
-
E
V
--
E
K
E
L
---
F
A
L
K
P
M
N
C
P
G
H
C
L
M
F
D
H
R
P
R
S
W
R
E
L
P
L
R
L
A
D
F
G
V
L
H
R
N
E
L
S
G
A
L
T
G
L
T
R
V
R
R
F
Q
Q
D
D
A
H
I
F
C
A
M
E
Q
I
E
D
E
I
K
G
C
L
D
F
L
R
T
V
Y
-
S
V
-
F
G
F
----
S
----
F
K
L
N
L
S
T
R
-
P
E
----
K
F
---
L
G
D
I
E
V
W
D
Q
A
E
K
Q
L
E
N
S
L
N
E
F
G
E
K
W
E
L
N
S
G
D
G
A
F
Y
G
P
K
I
D
I
Q
I
K
D
A
I
G
R
Y
H
Q
C
A
T
I
Q
L
D
F
Q
L
P
I
R
F
N
L
T
Y
V
S
H
D
G
D
D
-
K
K
R
P
V
I
V
H
R
A
I
L
G
S
V
E
R
M
I
A
I
L
T
E
N
Y
G
G
K
W
P
F
W
L
S
P
R
Q
V
M
V
V
P
V
G
-
P
-
T
---
C
---
D
E
Y
A
Q
K
V
R
Q
Q
F
H
D
--------------
A
--------------
K
F
M
A
D
I
D
L
D
P
-
G
C
T
L
N
K
K
I
R
N
A
Q
L
A
Q
Y
N
F
I
L
V
V
G
E
K
E
K
I
S
G
T
V
N
I
R
-----------------------------
43
PsiBlast_CBE
66.46
48%
-83
- C2 -
4P3N
2
SYTC_HUMAN
C:
[14-381]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
R
K
I
G
R
D
Q
E
L
Y
F
F
H
E
-
L
S
P
G
S
C
F
F
L
P
K
G
A
Y
I
Y
N
A
L
I
E
F
I
R
S
E
Y
-
R
-
K
R
G
F
Q
E
V
V
T
P
N
I
F
N
S
R
L
W
M
T
S
G
H
W
Q
H
Y
S
E
N
M
F
S
F
-
E
V
--
E
K
E
L
---
F
A
L
K
P
M
N
C
P
G
H
C
L
M
F
D
H
R
P
R
S
W
R
E
L
P
L
R
L
A
D
F
G
V
L
H
R
N
E
L
S
G
A
L
T
G
L
T
R
V
R
R
F
Q
Q
D
D
A
H
I
F
C
A
M
E
Q
I
E
D
E
I
K
G
C
L
D
F
L
R
T
V
Y
-
S
V
-
F
G
F
----
S
----
F
K
L
N
L
S
T
R
-
P
E
----
K
F
---
L
G
D
I
E
V
W
D
Q
A
E
K
Q
L
E
N
S
L
N
E
F
G
E
K
W
E
L
N
S
G
D
G
A
F
Y
G
P
K
I
D
I
Q
I
K
D
A
I
G
R
Y
H
Q
C
A
T
I
Q
L
D
F
Q
L
P
I
R
F
N
L
T
Y
V
S
H
D
G
D
D
-
K
K
R
P
V
I
V
H
R
A
I
L
G
S
V
E
R
M
I
A
I
L
T
E
N
Y
G
G
K
W
P
F
W
L
S
P
R
Q
V
M
V
V
P
V
G
-
P
-
T
---
C
---
D
E
Y
A
Q
K
V
R
Q
Q
F
H
D
--------------
A
--------------
K
F
M
A
D
I
D
L
D
P
-
G
C
T
L
N
K
K
I
R
N
A
Q
L
A
Q
Y
N
F
I
L
V
V
G
E
K
E
K
I
S
G
T
V
N
I
R
-----------------------------
45
PsiBlast_CBE
65.90
48%
-82
- C2 -
4TTV
2
SYTC_HUMAN
D:
[15-380]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
I
G
R
D
Q
E
L
Y
F
F
H
E
-
L
S
P
G
S
C
F
F
L
P
K
G
A
Y
I
Y
N
A
L
I
E
F
I
R
S
E
Y
-
R
-
K
R
G
F
Q
E
V
V
T
P
N
I
F
N
S
R
L
W
M
T
S
G
H
W
Q
H
Y
S
E
N
M
F
S
F
-
E
V
--
E
K
E
L
---
F
A
L
K
P
M
N
C
P
G
H
C
L
M
F
D
H
R
P
R
S
W
R
E
L
P
L
R
L
A
D
F
G
V
L
H
R
N
E
L
S
G
A
L
T
G
L
T
R
V
R
R
F
Q
Q
D
D
A
H
I
F
C
A
M
E
Q
I
E
D
E
I
K
G
C
L
D
F
L
R
T
V
Y
-
S
V
-
F
G
F
----
S
----
F
K
L
N
L
S
T
R
-
P
E
----
K
F
---
L
G
D
I
E
V
W
D
Q
A
E
K
Q
L
E
N
S
L
N
E
F
G
E
K
W
E
L
N
S
G
D
G
A
F
Y
G
P
K
I
D
I
Q
I
K
D
A
I
G
R
Y
H
Q
C
A
T
I
Q
L
D
F
Q
L
P
I
R
F
N
L
T
Y
V
S
H
D
G
D
D
-
K
K
R
P
V
I
V
H
R
A
I
L
G
S
V
E
R
M
I
A
I
L
T
E
N
Y
G
G
K
W
P
F
W
L
S
P
R
Q
V
M
V
V
P
V
G
-
P
-
T
---
C
---
D
E
Y
A
Q
K
V
R
Q
Q
F
H
D
--------------
A
--------------
K
F
M
A
D
I
D
L
D
P
-
G
C
T
L
N
K
K
I
R
N
A
Q
L
A
Q
Y
N
F
I
L
V
V
G
E
K
E
K
I
S
G
T
V
N
I
R
-----------------------------
46
PsiBlast_CBE
65.88
48%
-85
- C2 -
4TTV
2
SYTC_HUMAN
C:
[15-380]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
I
G
R
D
Q
E
L
Y
F
F
H
E
-
L
S
P
G
S
C
F
F
L
P
K
G
A
Y
I
Y
N
A
L
I
E
F
I
R
S
E
Y
-
R
-
K
R
G
F
Q
E
V
V
T
P
N
I
F
N
S
R
L
W
M
T
S
G
H
W
Q
H
Y
S
E
N
M
F
S
F
-
E
V
--
E
K
E
L
---
F
A
L
K
P
M
N
C
P
G
H
C
L
M
F
D
H
R
P
R
S
W
R
E
L
P
L
R
L
A
D
F
G
V
L
H
R
N
E
L
S
G
A
L
T
G
L
T
R
V
R
R
F
Q
Q
D
D
A
H
I
F
C
A
M
E
Q
I
E
D
E
I
K
G
C
L
D
F
L
R
T
V
Y
-
S
V
-
F
G
F
----
S
----
F
K
L
N
L
S
T
R
-
P
E
----
K
F
---
L
G
D
I
E
V
W
D
Q
A
E
K
Q
L
E
N
S
L
N
E
F
G
E
K
W
E
L
N
S
G
D
G
A
F
Y
G
P
K
I
D
I
Q
I
K
D
A
I
G
R
Y
H
Q
C
A
T
I
Q
L
D
F
Q
L
P
I
R
F
N
L
T
Y
V
S
H
D
G
D
D
-
K
K
R
P
V
I
V
H
R
A
I
L
G
S
V
E
R
M
I
A
I
L
T
E
N
Y
G
G
K
W
P
F
W
L
S
P
R
Q
V
M
V
V
P
V
G
-
P
-
T
---
C
---
D
E
Y
A
Q
K
V
R
Q
Q
F
H
D
--------------
A
--------------
K
F
M
A
D
I
D
L
D
P
-
G
C
T
L
N
K
K
I
R
N
A
Q
L
A
Q
Y
N
F
I
L
V
V
G
E
K
E
K
I
S
G
T
V
N
I
R
-----------------------------
34
PsiBlast_CBE
65.66
50%
-50
- C2 -
1FYF
2
SYT_ECOLI
B:
[1-368]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
-
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
-
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
T
-
S
S
--
E
N
R
E
---
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K---
I
V
V
K
L
S
T
R
-
P
E
----
K
R
---
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
-
E
D
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
-
S
---
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
-
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
-----------------------------
9
PsiBlast_PDB
65.56
50%
-51
- C2 -
1EVL
2
SYT_ECOLI
A:
[1-368]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
-
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
-
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
T
-
S
S
--
E
N
R
E
---
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K
---
I
V
V
K
L
S
T
R
-
P
E
----
K
R
---
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
-
E
D
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
-
S
---
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
-
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
-----------------------------
38
PsiBlast_CBE
65.51
50%
-47
- C2 -
1EVK
2
SYT_ECOLI
B:
[1-368]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
-
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
-
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
T
-
S
S
--
E
N
R
E
---
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K---
I
V
V
K
L
S
T
R
-
P
E
----
K
R
---
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
-
E
D
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
-
S
---
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
-
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
-----------------------------
6
PsiBlast_PDB
65.17
50%
-51
- C2 -
4HWR
2
SYT_ECOLI
A:
[3-370]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
-
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
-
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
T
-
S
S
--
E
N
R
E
---
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K
---
I
V
V
K
L
S
T
R
-
P
E
----
K
R
---
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
-
E
D
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
-
S
---
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
-
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
-----------------------------
40
PsiBlast_CBE
64.79
50%
-47
- C2 -
4P3O
7
SYT_ECOLI
B:
[2-369]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
-
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
-
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
T
-
S
S
--
E
N
R
E
---
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K---
I
V
V
K
L
S
T
R
-
P
E
----
K
R
---
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
-
E
D
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
-
S
---
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
-
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
-----------------------------
10
PsiBlast_PDB
64.78
50%
-53
- C2 -
1FYF
2
SYT_ECOLI
A:
[1-368]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
-
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
-
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
T
-
S
S
--
E
N
R
E
---
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K
---
I
V
V
K
L
S
T
R
-
P
E
----
K
R
---
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
-
E
D
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
-
S
---
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
-
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
-----------------------------
13
PsiBlast_PDB
64.74
50%
-46
- C2 -
4P3P
6
SYT_ECOLI
A:
[2-369]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
-
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
-
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
T
-
S
S
--
E
N
R
E
---
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K
---
I
V
V
K
L
S
T
R
-
P
E
----
K
R
---
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
-
E
D
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
-
S
---
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
-
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
-----------------------------
24
PsiBlast_CBE
64.71
50%
-56
- C2 -
4HWR
2
SYT_ECOLI
B:
[3-370]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
-
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
-
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
T
-
S
S
--
E
N
R
E
---
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K
---
I
V
V
K
L
S
T
R
-
P
E
----
K
R
---
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
-
E
D
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
-
S
---
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
-
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
-----------------------------
23
PsiBlast_CBE
64.54
50%
-51
- C2 -
4HWS
2
SYT_ECOLI
B:
[3-370]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
-
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
-
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
T
-
S
S
--
E
N
R
E
---
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K---
I
V
V
K
L
S
T
R
-
P
E
----
K
R
---
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
-
E
D
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
-
S
---
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
-
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
-----------------------------
25
PsiBlast_CBE
64.51
50%
-51
- C2 -
4HWP
2
SYT_ECOLI
B:
[3-370]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
-
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
-
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
T
-
S
S
--
E
N
R
E
---
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K---
I
V
V
K
L
S
T
R
-
P
E
----
K
R
---
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
-
E
D
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
-
S
---
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
-
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
-----------------------------
5
PsiBlast_PDB
64.10
50%
-53
- C2 -
4HWP
2
SYT_ECOLI
A:
[3-370]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
-
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
-
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
T
-
S
S
--
E
N
R
E
---
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K---
I
V
V
K
L
S
T
R
-
P
E
----
K
R
---
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
-
E
D
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
-
S
---
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
-
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
-----------------------------
26
PsiBlast_CBE
63.97
50%
-50
- C2 -
4HWO
2
SYT_ECOLI
B:
[3-370]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
-
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
-
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
T
-
S
S
--
E
N
R
E
---
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K---
I
V
V
K
L
S
T
R
-
P
E
----
K
R
---
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
-
E
D
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
-
S
---
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
-
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
-----------------------------
39
PsiBlast_CBE
63.42
50%
-45
- C2 -
4P3P
7
SYT_ECOLI
B:
[2-369]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
-
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
-
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
T
-
S
S
--
E
N
R
E
---
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K---
I
V
V
K
L
S
T
R
-
P
E
----
K
R
---
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
-
E
D
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
-
S
---
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
-
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
-----------------------------
4
PsiBlast_PDB
63.35
50%
-50
- C2 -
4HWO
2
SYT_ECOLI
A:
[3-370]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
-
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
-
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
T
-
S
S
--
E
N
R
E
---
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K---
I
V
V
K
L
S
T
R
-
P
E
----
K
R
---
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
-
E
D
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
-
S
---
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
-
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
-----------------------------
12
PsiBlast_PDB
63.27
50%
-46
- C2 -
4P3O
6
SYT_ECOLI
A:
[2-369]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
-
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
-
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
T
-
S
S
--
E
N
R
E
---
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K
---
I
V
V
K
L
S
T
R
-
P
E
----
K
R
---
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
-
E
D
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
-
S
---
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
-
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
-----------------------------
7
PsiBlast_PDB
62.05
50%
-52
- C2 -
4HWS
2
SYT_ECOLI
A:
[3-370]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
H
R
K
I
G
K
Q
L
D
L
Y
H
M
Q
E
-
E
A
P
G
M
V
F
W
H
N
D
G
W
T
I
F
R
E
L
E
V
F
V
R
S
K
L
-
K
-
E
Y
Q
Y
Q
E
V
K
G
P
F
M
M
D
R
V
L
W
E
K
T
G
H
W
D
N
Y
K
D
A
M
F
T
T
-
S
S
--
E
N
R
E
---
Y
C
I
K
P
M
N
C
P
G
H
V
Q
I
F
N
Q
G
L
K
S
Y
R
D
L
P
L
R
M
A
E
F
G
S
C
H
R
N
E
P
S
G
S
L
H
G
L
M
R
V
R
G
F
T
Q
D
D
A
H
I
F
C
T
E
E
Q
I
R
D
E
V
N
G
C
I
R
L
V
Y
D
M
Y
-
S
T
-
F
G
F
----
E
K---
I
V
V
K
L
S
T
R
-
P
E
----
K
R
---
I
G
S
D
E
M
W
D
R
A
E
A
D
L
A
V
A
L
E
E
N
N
I
P
F
E
Y
Q
L
G
E
G
A
F
Y
G
P
K
I
E
F
T
L
Y
D
C
L
D
R
A
W
Q
C
G
T
V
Q
L
D
F
S
L
P
S
R
L
S
A
S
Y
V
G
-
E
D
N
E
-
R
K
V
P
V
M
I
H
R
A
I
L
G
S
M
E
R
F
I
G
I
L
T
E
E
F
A
G
F
F
P
T
W
L
A
P
V
Q
V
V
I
M
N
I
T
-
D
-
S
---
Q
---
S
E
Y
V
N
E
L
T
Q
K
L
S
N
--------------
A
--------------
G
I
R
V
K
A
D
-
L
R
-
N
E
K
I
G
F
K
I
R
E
H
T
L
R
R
V
P
Y
M
L
V
C
G
D
K
E
V
E
S
G
K
V
A
V
R
-----------------------------
73
HHSearch
59.42
41%
0
- C2 -
3UH0
3
SYTM_YEAST
A:
[34-459]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
M
T
S
M
V
S
Q
R
Q
D
L
F
M
T
D
P
-
L
S
P
G
S
M
F
F
L
P
N
G
A
K
I
F
N
K
L
I
E
F
M
K
L
Q
Q
K
F
-
K
F
G
F
N
E
V
V
T
P
L
I
Y
K
K
T
L
W
E
K
S
G
H
W
E
N
Y
A
D
D
M
F
K
V
-
E
T
-----
E
---
Y
G
L
K
P
M
N
C
P
G
H
C
L
I
F
G
K
K
D
R
S
Y
N
E
L
P
L
R
F
S
D
F
S
P
L
H
R
N
E
A
S
G
A
L
S
G
L
T
R
L
R
K
F
H
Q
D
D
G
H
I
F
C
T
P
S
Q
V
K
S
E
I
F
N
S
L
K
L
I
D
I
V
Y
-
N
K
I
F
P
F
----
V
AESN
Y
F
I
N
F
S
T
R
-
P
D
----
H
F
---
I
G
D
L
K
V
W
N
H
A
E
Q
V
L
K
E
I
L
E
E
S
G
K
P
W
K
L
N
P
G
D
G
A
F
Y
G
P
K
L
D
I
M
V
T
D
H
L
R
K
T
H
Q
V
A
T
I
Q
L
D
F
Q
L
P
E
R
F
D
L
K
F
K
D
-
Q
D
N
S
-
Y
K
R
P
I
M
I
H
R
A
T
F
G
S
I
E
R
F
M
A
L
L
I
D
S
N
E
G
R
W
P
F
W
L
N
P
Y
Q
A
V
I
I
P
V
N
-
T
-
K
N
V
Q
Q
---
L
D
M
C
T
A
L
Q
K
K
L
R
N
ELEADDMEPVPLN
D
W
--------------
H
F
N
V
D
L
D
-
I
R
-
N
E
P
V
G
Y
R
I
K
S
A
I
L
K
N
Y
S
Y
L
I
I
V
G
D
E
E
V
Q
L
Q
K
Y
N
I
R
E
R
D
N
R
K
S
F
E
K
L
T
M
S
Q
I
W
E
K
F
I
E
L
E
K
N
Y
--
20
PsiBlast_PDB
54.63
41%
-5
- C2 -
4YYE
5
SYTM_YEAST
A:
[46-432]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
M
T
D
P
-
L
S
P
G
S
M
F
F
L
P
N
G
A
K
I
F
N
K
L
I
E
F
M
K
L
Q
Q
-
K
F
K
F
G
F
N
E
V
V
T
P
L
I
Y
K
K
T
L
W
E
K
S
G
H
W
E
N
Y
A
D
D
M
F
K
V
-
E
T
--
T
D
E
E
K
E
E
Y
G
L
K
P
M
N
C
P
G
H
C
L
I
F
G
K
K
D
R
S
Y
N
E
L
P
L
R
F
S
D
F
S
P
L
H
R
N
E
A
S
G
A
L
S
G
L
T
R
L
R
K
F
H
Q
D
D
G
H
I
F
C
T
P
S
Q
V
K
S
E
I
F
N
S
L
K
L
I
D
I
V
Y
N
K
I
-
F
P
-S---
N
----
Y
F
I
N
F
S
T
R
-
P
D
----
H
F
---
I
G
D
L
K
V
W
N
H
A
E
Q
V
L
K
E
I
L
E
E
S
G
K
P
W
K
L
N
P
G
D
G
A
F
Y
G
P
K
L
D
I
M
V
T
D
H
L
R
K
T
H
Q
V
A
T
I
Q
L
D
F
Q
L
P
E
R
F
D
L
K
F
K
D
-
Q
D
N
S
-
Y
K
R
P
I
M
I
H
R
A
T
F
G
S
I
E
R
F
M
A
L
L
I
D
S
N
E
G
R
W
P
F
W
L
N
P
Y
Q
A
V
I
I
P
V
N
-
T
-
K
---
N
V
Q
Q
L
D
M
C
T
A
L
Q
K
K
L
R
N
--------------
E
LEADDMEPVPLN
D
W
H
F
N
V
D
L
D
-
I
R
-
N
E
P
V
G
Y
R
I
K
S
A
I
L
K
N
Y
S
Y
L
I
I
V
G
D
E
E
V
Q
L
Q
K
Y
N
I
R
-----------------------------
48
PsiBlast_CBE
54.00
41%
-5
- C2 -
4YYE
3
SYTM_YEAST
B:
[46-433]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
M
T
D
P
-
L
S
P
G
S
M
F
F
L
P
N
G
A
K
I
F
N
K
L
I
E
F
M
K
L
Q
Q
-
K
F
K
F
G
F
N
E
V
V
T
P
L
I
Y
K
K
T
L
W
E
K
S
G
H
W
E
N
Y
A
D
D
M
F
K
V
-
E
T
--
T
D
E
E
KEE
Y
G
L
K
P
M
N
C
P
G
H
C
L
I
F
G
K
K
D
R
S
Y
N
E
L
P
L
R
F
S
D
F
S
P
L
H
R
N
E
A
S
G
A
L
S
G
L
T
R
L
R
K
F
H
Q
D
D
G
H
I
F
C
T
P
S
Q
V
K
S
E
I
F
N
S
L
K
L
I
D
I
V
Y
N
K
I
-
F
P
-S---
N
----
Y
F
I
N
F
S
T
R
-
P
D
----
H
F
---
I
G
D
L
K
V
W
N
H
A
E
Q
V
L
K
E
I
L
E
E
S
G
K
P
W
K
L
N
P
G
D
G
A
F
Y
G
P
K
L
D
I
M
V
T
D
H
L
R
K
T
H
Q
V
A
T
I
Q
L
D
F
Q
L
P
E
R
F
D
L
K
F
K
D
-
Q
D
N
S
-
Y
K
R
P
I
M
I
H
R
A
T
F
G
S
I
E
R
F
M
A
L
L
I
D
S
N
E
G
R
W
P
F
W
L
N
P
Y
Q
A
V
I
I
P
V
N
-
T
-
K
---
N
VQQ
L
D
M
C
T
A
L
Q
K
K
L
R
N
--------------
E
LEADDMEPVPLNDW
H
F
N
V
D
L
D
-
I
R
-
N
E
P
V
G
Y
R
I
K
S
A
I
L
K
N
Y
S
Y
L
I
I
V
G
D
E
E
V
Q
L
Q
K
Y
N
I
R
-----------------------------
19
PsiBlast_PDB
53.58
41%
3
- C2 -
3UH0
2
SYTM_YEAST
A:
[46-432]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
M
T
D
P
-
L
S
P
G
S
M
F
F
L
P
N
G
A
K
I
F
N
K
L
I
E
F
M
K
L
Q
Q
-
K
F
K
F
G
F
N
E
V
V
T
P
L
I
Y
K
K
T
L
W
E
K
S
G
H
W
E
N
Y
A
D
D
M
F
K
V
-
E
T
------E--
Y
G
L
K
P
M
N
C
P
G
H
C
L
I
F
G
K
K
D
R
S
Y
N
E
L
P
L
R
F
S
D
F
S
P
L
H
R
N
E
A
S
G
A
L
S
G
L
T
R
L
R
K
F
H
Q
D
D
G
H
I
F
C
T
P
S
Q
V
K
S
E
I
F
N
S
L
K
L
I
D
I
V
Y
N
K
I
-
F
P
F
VAES
N
----
Y
F
I
N
F
S
T
R
-
P
D
----
H
F
---
I
G
D
L
K
V
W
N
H
A
E
Q
V
L
K
E
I
L
E
E
S
G
K
P
W
K
L
N
P
G
D
G
A
F
Y
G
P
K
L
D
I
M
V
T
D
H
L
R
K
T
H
Q
V
A
T
I
Q
L
D
F
Q
L
P
E
R
F
D
L
K
F
K
D
-
Q
D
N
S
-
Y
K
R
P
I
M
I
H
R
A
T
F
G
S
I
E
R
F
M
A
L
L
I
D
S
N
E
G
R
W
P
F
W
L
N
P
Y
Q
A
V
I
I
P
V
N
-
T
-
K
---
N
V
Q
Q
L
D
M
C
T
A
L
Q
K
K
L
R
N
--------------
E
LEADDMEPVPLN
D
W
H
F
N
V
D
L
D
-
I
R
-
N
E
P
V
G
Y
R
I
K
S
A
I
L
K
N
Y
S
Y
L
I
I
V
G
D
E
E
V
Q
L
Q
K
Y
N
I
R
-----------------------------