@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu37600: (2016-08-02 )
MAYPNGKLSEEKVFKDPVHRYVHVRDKLIWDLIGTREFQRLRRIKQLGTTYLTFHGAEHSRFNHSLGVYEIVRRMVDDVFKGRPEWDDSERELCLAAALLHDLGHGPFSHSFEKVFHLDHEDFTRGIILGDTEVNQVLRKVSPGFPQDVAEVIAKTYKNKQVVSLISSQIDADRMDYLQRDAYYTGVSYGHFDMERILRVMRPREDQIVIKESGMHAVEDYIMSRYQMYWQVYFHPVTRSAEVILTKILHRAKQLHDEGYVFTHAPVHFYSIFEGKLTLEDYVKLDESIILYYFQAWEDEEDAILSDLCRRFINRQLFQYVEFNPNEEMSAYFELTSLFKEAGIDPSYYLVVDSSSDLPYDFYRPGEEEERLPIHLLTQNGQIKELSRQSAIVESISGKRRTDHKLYYPKDLICDGTKHPEAKMKIRQLLGLT
Atome Classification :
(23 SA)
.........10........20........30........40........50........60........70........80--------...-------.--....90.-....-...100.......110.------------------.--..--------.--..120.....--------..130---........------------140..---......150..---...----------..160------........---.170.......180.......190.......200----...----....210.......220.......230.......240.......250.......-260........270------...----------......280.......290.......300........310.......320.......330-.-----..-..-...-------340-----....---.....350.......360.......370.......380-.....--...390.......400........410.....-..420.......430.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAYPNGKL
S
E
E
K
V
F
K
D
P
V
H
R
Y
V
H
V
R
D
K
L
I
W
D
L
I
G
T
R
E
F
Q
R
L
R
R
I
K
Q
LGT
T
Y
L
T
F
HGAEHSRFNHSL
G
V
Y
E
I
V
R
R
M
V
D
D
V
FK--------GRP-------E--WD
D
S
E
R
E
-
L
C
L
A
-
A
A
L
L
H
DLGHGP
F
S
H
S
F
E
------------------
K
--
V
F
--------H--L
D
H
E
DFTR
G
I
--------
I
LG-
D
---
T
E
V
N
Q
V
L
R
------------K-VSP---GF
P
Q
D
V
A
E
V
I
A
---
K
T
Y----------KN
K
--------
Q
V
V
S
L
I
S
S
---QI
D
A
D
R
M
D
Y
L
Q
R
DAYYTGVSYG
H
F
D
M
E
R
I
L
R
V
MR----PRE----
D
Q
I
V
I
KESG
M
H
A
V
E
D
Y
I
M
S
R
Y
Q
M
Y
W
Q
V
Y
F
H
PVTR
S
A
E
V
I
L
T
K
I
L
H
R
A
K
Q
LHDEG-
Y
-
V
F
T
HA
P
V
H
F
Y
--------
S
IF----------EGKL
T
L
E
D
Y
V
KLD
E
S
I
I
L
Y
Y
FQAWEDE-
E
D
A
I
L
S
D
L
C
R
R
F
I
N
R
Q
L
F
Q
Y
VEFNP
N
E
E
M
S
A
--
Y
-----
F
E
-
L
T
-
S
L
F
-------
K
-------EAGI---DP
S
Y
Y
L
V
V
DSSSDLPYDFYRPGEEEERL
P
I
H
L
LTQNG--
Q
I
K
E
L
--
S
R
Q
S
A
I
V
E
S
ISGKRR-TDHKLYYP
K
D
LICDGT-KH
P
E
A
K
M
K
I
R
Q
L
LGLT
34
HHSearch
79.33
49%
-13
- C3 -
4LRL
5
?
A:
[30-472]
---
K
E
Q
R
L
P
I
E
K
V
F
R
D
P
V
H
N
Y
I
H
V
Q
H
Q
V
I
L
D
L
I
N
S
A
E
V
Q
R
L
R
R
I
K
Q
L
G
T
S
S
F
T
F
H
G
A
E
H
S
R
F
S
H
S
L
G
V
Y
E
I
T
R
R
I
C
E
I
F
Q
R
--------
N
Y
S
VERLGEN
G
--
W
N
D
D
E
R
L
-
I
T
L
C
-
A
A
L
L
H
D
V
G
H
G
P
Y
S
H
T
F
E
------------------
H
--
I
F
--------
D
--
T
N
H
E
A
I
T
V
Q
I
--------
I
T
S
-
P
E--
T
E
V
Y
Q
I
L
N
------------
R
-
V
S
A
---
D
F
P
E
K
V
A
S
V
I
T
---
K
Q
Y
----------
P
N
P
--------
Q
V
V
Q
M
I
S
S
---
Q
I
D
A
D
R
M
D
Y
L
L
R
D
A
Y
F
T
G
T
E
Y
G
T
F
D
L
T
R
I
L
R
V
I
R
----
P
Y
K
----
G
G
I
A
F
A
M
N
G
M
H
A
V
E
D
Y
I
V
S
R
Y
Q
M
Y
V
Q
V
Y
F
H
P
V
S
R
G
M
E
V
I
L
D
H
L
L
H
R
A
K
E
L
F
E
N
P
-
E
F
D
Y
D
L
Q
A
S
L
L
V
--------
P
F
F
----------
K
G
D
F
T
L
Q
E
Y
L
K
L
D
D
G
V
L
S
T
Y
F
T
Q
W
M
D
V
-
P
D
S
I
L
G
D
L
A
K
R
F
L
M
R
K
P
L
K
S
A
T
F
T
N
E
K
E
S
A
A
T
-
I
-----
A
Y
-
L
R
-
E
L
I
-------
E
-------
K
V
G
F
---
N
P
K
Y
Y
T
A
I
N
S
S
Y
D
L
P
Y
D
F
Y
R
P
N
K
D
R
H
R
T
Q
I
E
L
M
Q
K
D
G
--
S
L
V
E
L
--
A
T
V
S
P
L
V
A
A
L
A
G
Q
S
Q
-
G
D
E
R
F
Y
F
P
K
E
M
L
D
Q
--D
L
F
D
E
T
Y
R
E
F
S
S
Y
I
H
--
21
PsiBlast_CBE
75.03
49%
6
- C3 -
4LRL
5
?
C:
[27-454]
I
P
Y
K
E
Q
R
L
P
I
E
K
V
F
R
D
P
V
H
N
Y
I
H
V
Q
H
Q
V
I
L
D
L
I
N
S
A
E
V
Q
R
L
R
R
I
K
Q
L
G
T
S
S
F
T
F
H
G
A
E
H
S
R
F
S
H
S
L
G
V
Y
E
I
T
R
R
I
C
E
-
I
F
Q
R
NYSVERL
G
E
N
-------
G
--
W
N
D
D
E
R
L
-
I
T
L
C
-
A
A
L
L
H
D
V
G
H
G
P
Y
S
H
T
F
E
------------------
H
--
I
F
--------
D
--
T
N
H
E
A
I
T
V
Q
I
--------
I
T
S
P
E
---
T
E
V
Y
Q
I
L
N
------------
R
-
V
S
A
---
D
F
P
E
K
V
A
S
V
I
T
---
K
Q
Y
----------
P
N
P
--------
Q
V
V
Q
M
I
S
S
---
Q
I
D
A
D
R
M
D
Y
L
L
R
D
A
Y
F
T
G
T
E
Y
G
T
F
D
L
T
R
I
L
R
V
I
R
----
P
Y
K
----
G
G
I
A
F
A
M
N
G
M
H
A
V
E
D
Y
I
V
S
R
Y
Q
M
Y
V
Q
V
Y
F
H
P
V
S
R
G
M
E
V
I
L
D
H
L
L
H
R
A
K
E
L
F
E
N
P
E
F
-
D
Y
D
L
Q
A
S
L
L
V
--------
P
F
F
----------
K
G
D
F
T
L
Q
E
Y
L
K
L
D
D
G
V
L
S
T
Y
F
T
Q
W
M
D
V
-
P
D
S
I
L
G
D
L
A
K
R
F
L
M
R
K
P
L
K
S
A
T
F
T
N
E
K
E
S
A
A
--
T
-----
I
A
Y
L
R
-
E
L
I
-------
E
-------
K
V
G
F
---
N
P
K
Y
Y
T
A
I
N
S
S
Y
D
L
P
Y
D
F
Y
R
P
N
K
D
R
H
R
T
Q
I
E
L
M
Q
K
D
G
--
S
L
V
E
L
--
A
T
V
S
P
L
V
A
A
L
A
G
Q
S
Q
-
G
D
E
R
F
Y
F
P
K
E
M
L
D
Q
G
N
-
K
---------------
22
PsiBlast_CBE
73.96
49%
4
- C3 -
3IRH
4
?
B:
[27-454]
I
P
Y
K
E
Q
R
L
P
I
E
K
V
F
R
D
P
V
H
N
Y
I
H
V
Q
H
Q
V
I
L
D
L
I
N
S
A
E
V
Q
R
L
R
R
I
K
Q
L
G
T
S
S
F
T
F
H
G
A
E
H
S
R
F
S
H
S
L
G
V
Y
E
I
T
R
R
I
C
E
-
I
F
Q
R
NYSVERL
G
E
N
-------
G
--
W
N
D
D
E
R
L
-
I
T
L
C
-
A
A
L
L
H
D
V
G
H
G
P
Y
S
H
T
F
E
------------------
H
--
I
F
--------
D
--
T
N
H
E
A
I
T
V
Q
I
--------
I
T
S
P
E
---
T
E
V
Y
Q
I
L
N
------------
R
-
V
S
A
---
D
F
P
E
K
V
A
S
V
I
T
---
K
Q
Y
----------
P
N
P
--------
Q
V
V
Q
M
I
S
S
---
Q
I
D
A
D
R
M
D
Y
L
L
R
D
A
Y
F
T
G
T
E
Y
G
T
F
D
L
T
R
I
L
R
V
I
R
----
P
Y
K
----
G
G
I
A
F
A
M
N
G
M
H
A
V
E
D
Y
I
V
S
R
Y
Q
M
Y
V
Q
V
Y
F
H
P
V
S
R
G
M
E
V
I
L
D
H
L
L
H
R
A
K
E
L
F
E
N
P
E
F
-
D
Y
D
L
Q
A
S
L
L
V
--------
P
F
F
----------
K
G
D
F
T
L
Q
E
Y
L
K
L
D
D
G
V
L
S
T
Y
F
T
Q
W
M
D
V
-
P
D
S
I
L
G
D
L
A
K
R
F
L
M
R
K
P
L
K
S
A
T
F
T
N
E
K
E
S
A
A
--
T
-----
I
A
Y
L
R
-
E
L
I
-------
E
-------
K
V
G
F
---
N
P
K
Y
Y
T
A
I
N
S
S
Y
D
L
P
-----------
R
T
Q
I
E
L
M
Q
K
D
G
--
S
L
V
E
L
--
A
T
V
S
P
L
V
A
A
L
A
G
Q
S
Q
-
G
D
E
R
F
Y
F
P
K
E
M
L
D
Q
G
N
-
K
---------------
35
HHSearch
59.00
29%
-19
* C3 *
2Q14
6
?
A:
[5-407]
---------
E
R
K
I
I
N
D
P
V
F
G
F
I
N
I
P
K
G
L
L
Y
D
I
V
R
H
P
L
L
Q
R
L
T
R
I
K
Q
V
G
L
S
S
V
V
Y
P
G
A
Q
H
T
R
F
Q
H
S
L
G
A
F
Y
L
M
S
E
A
I
T
Q
L
T
S
--------
K
G
N
-------
F
--
I
F
D
S
E
A
E
-
A
V
Q
A
-
A
I
L
L
H
D
I
G
H
G
P
F
S
H
V
L
E
------------------
D
--
T
I
VQ------
G
--
V
S
H
E
E
I
S
L
M
L
--------
M
E
R
-
M
---------
N
K
------------
E
-
M
N
----
G
Q
L
S
L
A
I
Q
I
F
K
---
D
E
Y
----------
P
K
R
--------
F
L
H
Q
L
V
S
G
---
Q
L
D
M
D
R
L
D
Y
L
R
R
D
S
F
Y
T
G
V
T
E
G
N
I
G
S
A
R
I
I
K
M
L
D
----
V
A
D
----
D
R
L
V
I
E
S
K
G
I
Y
S
I
E
N
F
L
T
A
R
R
L
M
Y
W
Q
V
Y
L
H
K
T
S
V
A
Y
E
R
M
L
I
S
T
L
L
R
A
K
E
L
A
S
Q
G
-
V
-
E
L
F
A
-
S
P
A
L
H
--------
F
F
L
Y
N
DIN
H
T
E
F
H
N
N
P
D
C
L
E
N
F
I
Q
L
D
D
N
D
I
W
T
A
L
K
V
W
S
N
H
-
P
D
K
V
L
S
T
L
S
L
G
M
I
N
R
N
I
F
K
V
E
N
S
A
E
P
I
G
E
D
R
--
I
-----
K
E
-
L
T
L
Q
I
S
-------
Q
-------
Q
L
G
I
TLS
E
A
N
Y
F
V
S
T
P
S
I
E
K
N
M
Y
D
P
-------
A
D
D
S
I
D
I
I
Y
K
D
G
--
T
I
K
N
I
--
A
E
A
S
D
M
L
N
I
S
L
L
S
K
K
V
K
K
Y
Y
L
C
Y
Q
R
------------------------
1
PsiBlast_PDB
58.46
30%
-26
- C3 -
2Q14
6
?
A:
[5-386]
---------
E
R
K
I
I
N
D
P
V
F
G
F
I
N
I
P
K
G
L
L
Y
D
I
V
R
H
P
L
L
Q
R
L
T
R
I
K
Q
V
G
L
S
S
V
V
Y
P
G
A
Q
H
T
R
F
Q
H
S
L
G
A
F
Y
L
M
S
E
A
I
T
Q
L
T
S
--------
K
G
N
-------
F
--
I
F
D
S
E
A
E
-
A
V
Q
A
-
A
I
L
L
H
D
I
G
H
G
P
F
S
H
V
L
E
------------------
D
TI
V
Q
--------
G
--
V
S
H
E
E
I
S
-------------------
L
M
L
M
E
R
M
N
------------
K
-
E
M
N
---
G
Q
L
S
L
A
I
Q
I
F
K
---
D
E
Y
----------
P
K
R
--------
F
L
H
Q
L
V
S
G
---
Q
L
D
M
D
R
L
D
Y
L
R
R
D
S
F
Y
T
G
V
T
E
G
N
I
G
S
A
R
I
I
K
M
L
D
----
V
A
D
----
D
R
L
V
I
E
S
K
G
I
Y
S
I
E
N
F
L
T
A
R
R
L
M
Y
W
Q
V
Y
L
H
K
T
S
V
A
Y
E
R
M
L
I
S
T
L
L
R
A
K
E
L
A
S
Q
G
-
V
E
L
F
A
S
P
A
L
H
F
F
L
Y
N
DIN
H
T
E
F
H
----------
N
N
P
D
C
L
E
N
F
I
Q
L
D
D
N
D
I
W
T
A
L
K
V
W
S
N
H
-
P
D
K
V
L
S
T
L
S
L
G
M
I
N
R
N
I
F
K
-
V
E
-
N
S
A
E
P
I
G
E
D
R
I
-----
K
E
-
L
T
L
Q
I
S
-------
Q
-------
Q
L
G
I
---
T
L
S
E
A
N
Y
F
V
S
T
P
S
I
E
K
N
M
Y
D
P
A
D
D
S
----
I
D
I
I
Y
K
D
G
--
T
I
K
N
I
--
A
E
A
S
---------------------------------------------
37
HHSearch
51.42
33%
-26
- C3 -
2HEK
13
?
A:
[2-365]
----------
I
K
E
F
S
D
P
L
Y
G
F
V
R
V
G
-
E
A
G
L
R
L
I
D
S
F
P
F
Q
R
L
R
Y
V
K
Q
L
G
L
A
Y
L
V
F
P
S
A
Q
H
T
R
F
E
H
S
L
G
V
Y
H
I
T
E
R
I
C
E
S
L
K
V
------------------------
K
E
K
E
-
L
V
K
L
-
A
G
L
L
H
D
L
G
H
P
P
F
S
H
T
T
E
------------------
V
--
L
L
P
R
------
E
--
R
S
H
E
D
F
T
E
R
V
--------
I
K
E
-----
T
E
I
Y
E
I
L
K
------------
Q
D
Y
S
H
---
E
D
I
E
R
L
V
R
I
T
L
---
G
K
P
ED
E
-------
E
E
K
--------
L
L
S
E
I
I
T
G
---
E
F
G
S
D
R
M
D
Y
L
R
R
D
A
Y
F
C
G
V
S
Y
G
F
F
D
Y
D
R
L
I
S
T
L
R
----
V
Y
E
----
N
K
V
V
V
D
E
S
G
L
R
A
L
E
N
F
L
I
S
R
Y
F
M
Y
V
Q
V
Y
F
H
K
V
V
R
I
L
S
I
H
L
V
E
F
L
K
K
L
I
S
Q
E
--------------------------------------
D
F
T
D
I
N
N
F
L
R
L
N
D
A
F
V
I
S
E
L
F
K
R
K
------
A
F
R
E
D
F
E
R
I
F
Q
R
K
H
F
K
T
L
L
S
T
E
N
Y
E
K
----
F
-----
S
E
-
T
K
E
R
L
L
-------
E
-------
K
F
------
P
Q
E
K
V
R
F
D
E
V
E
K
E
V
Y
----------
G
G
N
I
Y
V
L
S
-
S
E
--
G
L
K
K
A
--
H
E
L
S
P
L
I
A
S
L
K
P
I
---
K
L
Y
R
I
Y
V
D
R
Q
L
W
E
K
A
R
-----------------
38
HHSearch
51.05
24%
-26
- C3 -
5AO0
4
SAMH1_HUMAN
A:
[95-557]
--------
D
T
M
K
V
I
N
D
P
I
H
G
H
I
E
L
H
-
P
L
L
V
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
V
H
A
L
G
E
--------
K
Q
P
EL-----
Q
--
I
S
E
R
D
V
L
-
C
V
Q
I
-
A
G
L
C
H
D
L
G
H
G
P
F
S
H
M
F
D
------------------
G
--
R
F
I
P
L
A
RPE
V
K
--
W
T
H
E
Q
G
S
V
M
M
--------
F
E
H
-
L
I
N
S
N
G
I
K
P
V
M
E
------------
Q
-
Y
G
L
I
P
E
E
D
I
C
F
I
K
E
Q
I
V
---
G
P
-LWPYKGRPE-
N
K
S
--------
F
L
Y
E
I
V
S
N
KRN
G
I
D
V
D
K
W
D
Y
F
A
R
D
C
H
H
L
G
I
Q
-
N
N
F
D
Y
K
R
F
I
K
F
A
R
----
V
C
E
V
DN
E
L
R
I
C
A
R
D
K
E
V
G
N
L
Y
D
M
F
H
T
R
N
S
L
H
R
R
A
Y
Q
H
K
V
G
N
I
I
D
T
M
I
T
D
A
F
L
K
A
D
D
Y
I
E
I
T
-
G
-
A
----
G
G
K
K
Y
--------
R
I
S
----------
T
A
I
D
D
M
E
A
Y
T
K
L
T
D
N
I
F
L
E
I
L
Y
S
T
-
D
P
-
K
L
K
D
A
R
E
I
L
K
Q
I
E
Y
R
N
L
F
K
Y
V
G
E
T
Q
P
T
G
Q
I
K
--
I
KREDY
E
S
-
L
P
K
E
V
A
-------
S
AKPKVLL
D
V
K
L
---
K
A
E
D
-
F
I
V
D
V
I
N
M
---------------
H
V
S
F
Y
C
K
T
A
PN
R
A
I
R
---------------
E
---
Q
L
I
R
V
Y
C
K
K
V
D
R
K
S
L
Y
----
A
A
R
Q
Y
F
V
Q
W
C
A
D
-
20
PsiBlast_PDB
50.62
27%
-39
- C3 -
4ZWG
7
SAMH1_HUMAN
A:
[4-349]
-----------
K
V
I
N
D
P
I
H
G
H
I
E
L
H
P
L
L
V
-
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
V
H
A
L
G
E
--------
K
Q
P
-------
E
--
L
Q
I
S
E
R
D
V
L
C
V
Q
I
A
G
L
C
R
N
L
G
H
G
P
F
S
H
M
F
D
GR
F
I
P
L
A
RPE
V
K
W
T
H
E
Q
G
S
--
V
M
--------
M
--
F
E
H
L
I
N
S
N
G
I
K
P
V
M
E
Q
Y
G
L
I
P
-
E
---
E
D
I
C
F
I
K
E
------------
Q
-
I
V
G
---
P
L
E
---
E
D
S
L
W
----
P
Y
----------
K
G
R
PENK
S
F
L
Y
E
I
V
S
N
K
R
N
---
G
I
D
V
D
K
W
D
Y
F
A
R
D
C
H
H
L
G
I
Q
-
N
N
F
D
Y
K
R
F
I
K
F
A
R
V
C
E
V
D
N
E
----
L
R
I
C
A
R
D
K
E
V
G
N
L
Y
D
M
F
H
T
R
N
S
L
H
R
R
A
Y
Q
H
K
V
G
N
I
I
D
T
M
I
T
D
A
F
L
K
A
----
D
D
Y
-
I
-
E
I
T
G
A
G
G
K
K
Y
--------
R
I
S
----------
T
A
I
D
D
M
E
A
Y
T
K
L
T
D
N
I
F
L
E
I
L
Y
S
T
D
P
K
L
K
D
A
--
R
E
I
L
K
Q
I
E
Y
R
N
L
F
K
Y
V
------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
50.23
28%
-51
- C3 -
4RXO
4
SAMH1_HUMAN
A:
[29-378]
-----------
K
V
I
N
D
P
I
H
G
H
I
E
L
H
P
L
L
V
-
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
V
H
A
L
G
E
--------
K
Q
P
-------
E
--
L
Q
I
S
E
R
D
V
L
C
V
Q
I
A
G
L
C
H
D
L
G
H
G
P
F
S
H
M
F
D
GR
F
I
P
L
A
RPE
V
K
W
T
H
E
Q
G
S
--
V
M
--------
M
--
F
E
H
L
I
N
S
N
G
I
K
P
V
M
E
Q
Y
G
L
I
P
-
E
---
E
D
I
Y
F
I
K
E
------------
Q
-
I
V
G
---
P
L
E
------
L
W
----
P
Y
----------
K
G
R
PENK
S
F
L
Y
E
I
V
S
N
K
R
N
---
G
I
D
V
D
K
W
D
Y
F
A
R
D
C
H
H
L
G
I
Q
-
N
N
F
D
Y
K
R
F
I
K
F
A
R
V
C
E
V
D
N
E
----
L
R
I
C
A
R
D
K
E
V
G
N
L
Y
D
M
F
H
T
R
N
S
L
H
R
R
A
Y
Q
H
K
V
G
N
I
I
D
T
M
I
T
D
A
F
L
K
A
----
D
D
Y
-
I
-
E
I
T
G
A
G
G
K
K
Y
--------
R
I
S
----------
T
A
I
D
D
M
E
A
Y
T
K
L
T
D
N
I
F
L
E
I
L
Y
S
T
D
P
K
L
K
D
A
--
R
E
I
L
K
Q
I
E
Y
R
N
L
F
K
Y
V
------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
49.85
28%
-43
- C3 -
4Q7H
3
SAMH1_HUMAN
A:
[16-366]
-----------
K
V
I
N
D
P
I
H
G
H
I
E
L
H
P
L
L
V
-
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
V
H
A
L
G
E
--------
K
Q
P
-------
E
--
L
Q
I
S
E
R
D
V
L
C
V
Q
I
A
G
L
C
H
D
L
G
H
G
P
F
S
H
M
F
D
GR
F
I
P
L
A
RPEVKWT
H
E
Q
G
S
--
V
M
--------
M
--
F
E
H
L
I
N
S
N
G
I
K
P
V
M
E
Q
Y
G
L
I
P
-
E
---
E
D
I
Y
F
I
K
E
------------
Q
-
I
V
G
---
P
L
E
S
P
--
D
S
L
W
----
P
Y
----------
K
G
R
PENK
S
F
L
Y
E
I
V
S
N
K
R
N
---
G
I
D
V
D
K
W
D
Y
F
A
R
D
C
H
H
L
G
I
Q
-
N
N
F
D
Y
K
R
F
I
K
F
A
R
V
C
E
V
D
N
E
----
L
R
I
C
A
R
D
K
E
V
G
N
L
Y
D
M
F
H
T
R
N
S
L
H
R
R
A
Y
Q
H
K
V
G
N
I
I
D
T
M
I
T
D
A
F
L
K
A
----
D
D
Y
-
I
-
E
I
T
G
A
G
G
K
K
Y
--------
R
I
S
----------
T
A
I
D
D
M
E
A
Y
T
K
L
T
D
N
I
F
L
E
I
L
Y
S
T
D
P
K
L
K
D
A
--
R
E
I
L
K
Q
I
E
Y
R
N
L
F
K
Y
V
------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
49.60
28%
-54
- C3 -
4MZ7
7
SAMH1_HUMAN
A:
[29-370]
-----------
K
V
I
N
D
P
I
H
G
H
I
E
L
H
P
L
L
V
-
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
V
H
A
L
G
E
--------
K
Q
P
-------
E
--
L
Q
I
S
E
R
D
V
L
C
V
Q
I
A
G
L
C
H
D
L
G
H
G
P
F
S
H
M
F
D
GRFIPLARPEVKWT
H
E
Q
G
S
--
V
M
--------
M
--
F
E
H
L
I
N
S
N
G
I
K
P
V
M
E
Q
Y
G
L
I
P
-
E
---
E
D
I
Y
F
I
K
E
------------
Q
-
I
V
G
---
P
L
E
------
L
W
----
P
Y
----------
K
G
R
PENK
S
F
L
Y
E
I
V
S
N
K
R
N
---
G
I
D
V
D
K
W
D
Y
F
A
R
D
C
H
H
L
G
I
Q
-
N
N
F
D
Y
K
R
F
I
K
F
A
R
V
C
E
V
D
N
E
----
L
R
I
C
A
R
D
K
E
V
G
N
L
Y
D
M
F
H
T
R
N
S
L
H
R
R
A
Y
Q
H
K
V
G
N
I
I
D
T
M
I
T
D
A
F
L
K
A
----
D
D
Y
-
I
-
E
I
T
G
A
G
G
K
K
Y
--------
R
I
S
----------
T
A
I
D
D
M
E
A
Y
T
K
L
T
D
N
I
F
L
E
I
L
Y
S
T
D
P
K
L
K
D
A
--
R
E
I
L
K
Q
I
E
Y
R
N
L
F
K
Y
V
------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
49.34
24%
-19
- C3 -
4MZ7
7
SAMH1_HUMAN
A:
[26-487]
--------
D
T
M
K
V
I
N
D
P
I
H
G
H
I
E
L
H
-
P
L
L
V
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
V
H
A
L
G
E
--------
K
Q
P
-------
E
LQ
I
S
E
R
D
V
L
-
C
V
Q
I
-
A
G
L
C
H
D
L
G
H
G
P
F
S
H
M
F
D
------------------
G
--
R
F
IPLARPEV
K
--
W
T
H
E
Q
G
S
V
M
M
--------
F
E
H
-
L
I
N
S
N
G
I
K
P
V
M
E
------------
Q
-
Y
G
L
I
P
E
E
D
I
Y
F
I
K
E
Q
I
V
---
G
P
L
ELWPYKGRPE
N
K
S
--------
F
L
Y
E
I
V
S
N
KRN
G
I
D
V
D
K
W
D
Y
F
A
R
D
C
H
H
L
G
I
Q
-
N
N
F
D
Y
K
R
F
I
K
F
A
R
----
V
C
E
V
DNE
L
R
I
C
A
R
D
K
E
V
G
N
L
Y
D
M
F
H
T
R
N
S
L
H
R
R
A
Y
Q
H
K
V
G
N
I
I
D
T
M
I
T
D
A
F
L
K
A
D
D
Y
I
E
I
T
-
G
-----
A
G
G
K
K
Y
--------
R
I
S
----------
T
A
I
D
D
M
E
A
Y
T
K
L
T
D
N
I
F
L
E
I
L
Y
S
T
D
-
P
-
K
L
K
D
A
R
E
I
L
K
Q
I
E
Y
R
N
L
F
K
Y
V
G
E
T
Q
P
T
G
Q
I
K
--
I
K
REDY
E
S
-
L
P
K
E
V
A
S
AKPKVL
L
-------
D
V
K
L
---
K
A
E
D
-
F
I
V
D
V
I
N
M
-
D
Y
G
M
---
Q
E
K
N
P
I
D
H
V
S
F
Y
C
K
T
A
PN
R
A
I
R
I
T
K
N
Q
V
S
Q
L
L
P
E
K
F
A
E
---
Q
L
I
R
V
Y
C
K
K
V
D
R
K
S
L
Y
----
A
A
R
Q
Y
F
V
Q
W
C
A
--
25
Fugue
49.07
30%
-1
- C3 -
2HEK
13
?
A:
[1-369]
---------
M
I
K
E
F
S
D
P
L
Y
G
F
V
R
V
G
-
E
A
G
L
R
L
I
D
S
F
P
F
Q
R
L
R
Y
V
K
Q
L
G
L
A
Y
L
V
F
P
S
A
Q
H
T
R
F
E
H
S
L
G
V
Y
H
I
T
E
R
I
C
E
S
L
------------------------
K
V
K
E
K
E
-
L
V
K
L
-
A
G
L
L
H
D
L
G
H
P
P
F
S
H
T
T
E
------------------
V
--
L
L
--------
P
R
E
R
S
H
E
D
F
T
E
R
V
--------
I
K
E
-
T
---
E
I
Y
E
I
L
K
Q
------------
D
-
Y
S
H
---
E
D
I
E
R
L
V
R
I
T
L
GKP
E
D
E
----------
E
E
K
--------
L
L
S
E
I
I
T
G
---
E
F
G
S
D
R
M
D
Y
L
R
R
D
A
Y
F
C
G
V
S
Y
G
F
F
D
Y
D
R
L
I
S
T
L
R
----
V
Y
E
----
N
K
V
V
V
D
E
S
G
L
R
A
L
E
N
F
L
I
S
R
Y
F
M
Y
V
Q
V
Y
F
H
K
V
V
R
I
L
S
I
H
L
V
E
F
L
K
K
L
I
S
Q
E
D
--------------------------------------
F
T
D
I
N
N
F
L
R
L
N
D
A
F
V
I
S
E
L
F
K
R
K
A
F
------
R
E
D
F
E
R
I
F
Q
R
K
H
F
K
T
L
L
S
T
E
N
--
Y
E
K
--
F
-----
S
E
-
T
K
-
E
R
L
-------
L
-------
E
K
F
P
---
Q
E
K
V
R
F
D
E
V
E
K
E
V
Y
G
G
N
I
-------------
Y
V
L
S
S
E
--
G
L
K
K
A
--
H
E
L
S
P
L
I
A
S
L
--
K
P
I
-
K
L
Y
R
I
Y
V
D
R
Q
-------
L
W
E
K
A
R
S
E
L
K
------
13
PsiBlast_PDB
49.02
27%
-50
- C3 -
4BZB
8
SAMH1_HUMAN
A:
[40-381]
-----------
K
V
I
N
D
P
I
H
G
H
I
E
L
H
P
L
L
V
-
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
V
H
A
L
G
E
--------
K
Q
P
-------
E
--
L
Q
I
S
E
R
D
V
L
C
V
Q
I
A
G
L
C
R
N
L
G
H
G
P
F
S
H
M
F
D
G
R
F
I
P
L
A
RPE
V
K
W
T
H
E
Q
G
S
--
V
M
--------
M
--
F
E
H
L
I
N
S
N
G
I
K
P
V
M
E
Q
Y
G
L
I
P
-
E
---
E
D
I
C
F
I
K
E
------------
Q
-
I
V
G
---
P
L
E
------
L
W
----
P
Y
----------
K
G
R
PENK
S
F
L
Y
E
I
V
S
N
K
R
N
---
G
I
D
V
D
K
W
D
Y
F
A
R
D
C
H
H
L
G
I
Q
-
N
N
F
D
Y
K
R
F
I
K
F
A
R
V
C
E
V
D
N
E
----
L
R
I
C
A
R
D
K
E
V
G
N
L
Y
D
M
F
H
T
R
N
S
L
H
R
R
A
Y
Q
H
K
V
G
N
I
I
D
T
M
I
T
D
A
F
L
K
A
----
D
D
Y
-
I
-
E
I
T
G
A
G
G
K
K
Y
--------
R
I
S
----------
T
A
I
D
D
M
E
A
Y
T
K
L
T
D
N
I
F
L
E
I
L
Y
S
T
D
P
K
L
K
D
A
--
R
E
I
L
K
Q
I
E
Y
R
N
L
F
K
Y
V
------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
48.98
27%
-48
- C3 -
5AO2
3
SAMH1_HUMAN
A:
[24-390]
-----------
K
V
I
N
D
P
I
H
G
H
I
E
L
H
P
L
L
V
-
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
A
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
V
H
A
L
G
E
--------
K
Q
P
-------
E
--
L
Q
I
S
E
R
D
V
L
C
V
Q
I
A
G
L
C
H
D
L
G
H
G
P
F
S
H
M
F
D
GR
F
I
P
L
A
RPE
V
K
W
T
H
E
Q
G
S
--
V
M
--------
M
--
F
E
H
L
I
N
S
N
G
I
K
P
V
M
E
Q
Y
G
L
I
P
-
E
---
E
D
I
C
F
I
K
E
------------
Q
-
I
V
G
---
P
L
-------
L
W
----
P
Y
----------
K
G
R
PENK
S
F
L
Y
E
I
V
S
N
K
R
N
---
G
I
D
V
D
K
W
D
Y
F
A
R
D
C
H
H
L
G
I
Q
-
N
N
F
D
Y
K
R
F
I
K
F
A
R
V
C
E
V
D
N
E
----
L
R
I
C
A
R
D
K
E
V
G
N
L
Y
D
M
F
H
T
R
N
S
L
H
R
R
A
Y
Q
H
K
V
G
N
I
I
D
T
M
I
T
D
A
F
L
K
A
----
D
D
Y
-
I
-
E
I
T
G
A
G
G
K
K
Y
--------
R
I
S
----------
T
A
I
D
D
M
E
A
Y
T
K
L
T
D
N
I
F
L
E
I
L
Y
S
T
D
P
K
L
K
D
A
--
R
E
I
L
K
Q
I
E
Y
R
N
L
F
K
Y
V
------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
48.88
28%
-39
- C3 -
4RXQ
6
SAMH1_HUMAN
A:
[29-370]
-----------
K
V
I
N
D
P
I
H
G
H
I
E
L
H
P
L
L
V
-
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
V
H
A
L
G
E
--------
K
Q
P
-------
E
--
L
Q
I
S
E
R
D
V
L
C
V
Q
I
A
G
L
C
H
D
L
G
H
G
P
F
S
H
M
F
D
GRFIPLARPE
V
K
W
T
H
E
Q
G
S
--
V
M
--------
M
--
F
E
H
L
I
N
S
N
G
I
K
P
V
M
E
Q
Y
G
L
I
P
-
E
---
E
D
I
Y
F
I
K
E
------------
Q
-
I
V
G
---
P
L
E
S
-----
L
W
----
P
Y
----------
K
G
R
PENK
S
F
L
Y
E
I
V
S
N
K
R
N
---
G
I
D
V
D
K
W
D
Y
F
A
R
D
C
H
H
L
G
I
Q
-
N
N
F
D
Y
K
R
F
I
K
F
A
R
V
C
E
V
D
N
E
----
L
R
I
C
A
R
D
K
E
V
G
N
L
Y
D
M
F
H
T
R
N
S
L
H
R
R
A
Y
Q
H
K
V
G
N
I
I
D
T
M
I
T
D
A
F
L
K
A
----
D
D
Y
-
I
-
E
I
T
G
A
G
G
K
K
Y
--------
R
I
S
----------
T
A
I
D
D
M
E
A
Y
T
K
L
T
D
N
I
F
L
E
I
L
Y
S
T
D
P
K
L
K
D
A
--
R
E
I
L
K
Q
I
E
Y
R
N
L
F
K
Y
V
------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
48.86
28%
-47
- C3 -
4RXS
6
SAMH1_HUMAN
A:
[29-370]
-----------
K
V
I
N
D
P
I
H
G
H
I
E
L
H
P
L
L
V
-
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
V
H
A
L
G
E
--------
K
Q
P
-------
E
--
L
Q
I
S
E
R
D
V
L
C
V
Q
I
A
G
L
C
H
D
L
G
H
G
P
F
S
H
M
F
D
GRFIPLARPE
V
K
W
T
H
E
Q
G
S
--
V
M
--------
M
--
F
E
H
L
I
N
S
N
G
I
K
P
V
M
E
Q
Y
G
L
I
P
-
E
---
E
D
I
Y
F
I
K
E
------------
Q
-
I
V
G
---
P
L
E
------
L
W
----
P
Y
----------
K
G
R
PENK
S
F
L
Y
E
I
V
S
N
K
R
N
---
G
I
D
V
D
K
W
D
Y
F
A
R
D
C
H
H
L
G
I
Q
-
N
N
F
D
Y
K
R
F
I
K
F
A
R
V
C
E
V
D
N
E
----
L
R
I
C
A
R
D
K
E
V
G
N
L
Y
D
M
F
H
T
R
N
S
L
H
R
R
A
Y
Q
H
K
V
G
N
I
I
D
T
M
I
T
D
A
F
L
K
A
----
D
D
Y
-
I
-
E
I
T
G
A
G
G
K
K
Y
--------
R
I
S
----------
T
A
I
D
D
M
E
A
Y
T
K
L
T
D
N
I
F
L
E
I
L
Y
S
T
D
P
K
L
K
D
A
--
R
E
I
L
K
Q
I
E
Y
R
N
L
F
K
Y
V
------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
48.61
28%
-38
- C3 -
4RXP
6
SAMH1_HUMAN
A:
[29-370]
-----------
K
V
I
N
D
P
I
H
G
H
I
E
L
H
P
L
L
V
-
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
V
H
A
L
G
E
--------
K
Q
P
-------
E
--
L
Q
I
S
E
R
D
V
L
C
V
Q
I
A
G
L
C
H
D
L
G
H
G
P
F
S
H
M
F
D
GRFIPLARPE
V
K
W
T
H
E
Q
G
S
--
V
M
--------
M
--
F
E
H
L
I
N
S
N
G
I
K
P
V
M
E
Q
Y
G
L
I
P
-
E
---
E
D
I
Y
F
I
K
E
------------
Q
-
I
V
G
---
P
L
E
S
-----
L
W
----
P
Y
----------
K
G
R
PENK
S
F
L
Y
E
I
V
S
N
K
R
N
---
G
I
D
V
D
K
W
D
Y
F
A
R
D
C
H
H
L
G
I
Q
-
N
N
F
D
Y
K
R
F
I
K
F
A
R
V
C
E
V
D
N
E
----
L
R
I
C
A
R
D
K
E
V
G
N
L
Y
D
M
F
H
T
R
N
S
L
H
R
R
A
Y
Q
H
K
V
G
N
I
I
D
T
M
I
T
D
A
F
L
K
A
----
D
D
Y
-
I
-
E
I
T
G
A
G
G
K
K
Y
--------
R
I
S
----------
T
A
I
D
D
M
E
A
Y
T
K
L
T
D
N
I
F
L
E
I
L
Y
S
T
D
P
K
L
K
D
A
--
R
E
I
L
K
Q
I
E
Y
R
N
L
F
K
Y
V
------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
48.57
27%
-53
- C3 -
4QG4
7
SAMH1_HUMAN
A:
[40-381]
-----------
K
V
I
N
D
P
I
H
G
H
I
E
L
H
P
L
L
V
-
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
V
H
A
L
G
E
--------
K
Q
P
-------
E
--
L
Q
I
S
E
R
D
V
L
C
V
Q
I
A
G
L
C
H
D
L
G
A
G
P
F
S
H
M
F
D
GRFIPLARPE
V
K
W
T
H
E
Q
G
S
--
V
M
--------
M
--
F
E
H
L
I
N
S
N
G
I
K
P
V
M
E
Q
Y
G
L
I
P
-
E
---
E
D
I
C
F
I
K
E
------------
Q
-
I
V
G
---
P
L
E
------
L
W
----
P
Y
----------
K
G
R
PENK
S
F
L
Y
E
I
V
S
N
K
R
N
---
G
I
D
V
D
K
W
D
Y
F
A
R
D
C
H
H
L
G
I
Q
-
N
N
F
D
Y
K
R
F
I
K
F
A
R
V
C
E
V
D
N
E
----
L
R
I
C
A
R
D
K
E
V
G
N
L
Y
D
M
F
H
T
R
N
S
L
H
R
R
A
Y
Q
H
K
V
G
N
I
I
D
T
M
I
T
D
A
F
L
K
A
----
D
D
Y
-
I
-
E
I
T
G
A
G
G
K
K
Y
--------
R
I
S
----------
T
A
I
D
D
M
E
A
Y
T
K
L
T
D
N
I
F
L
E
I
L
Y
S
T
D
P
K
L
K
D
A
--
R
E
I
L
K
Q
I
E
Y
R
N
L
F
K
Y
V
------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
48.45
27%
-49
- C3 -
4QFX
8
SAMH1_HUMAN
A:
[40-381]
-----------
K
V
I
N
D
P
I
H
G
H
I
E
L
H
P
L
L
V
-
R
I
I
D
T
P
Q
F
Q
R
L
R
Y
I
K
Q
L
G
G
G
Y
Y
V
F
P
G
A
S
H
N
R
F
E
H
S
L
G
V
G
Y
L
A
G
C
L
V
H
A
L
G
E
--------
K
Q
P
-------
E
--
L
Q
I
S
E
R
D
V
L
C
V
Q
I
A
G
L
C
R
N
L
G
H
G
P
F
S
H
M
F
D
GR
F
I
P
L
A
RPEVKWT
H
E
Q
G
S
--
V
M
--------
M
--
F
E
H
L
I
N
S
N
G
I
K
P
V
M
E
Q
Y
G
L
I
P
-
E
---
E
D
I
C
F
I
K
E
------------
Q
-
I
V
G
---
P
L
E
------
L
W
----
P
Y
----------
K
G
R
PENK
S
F
L
Y
E
I
V
S
N
K
R
N
---
G
I
D
V
D
K
W
D
Y
F
A
R
D
C
H
H
L
G
I
Q
-
N
N
F
D
Y
K
R
F
I
K
F
A
R
V
C
E
V
D
N
E
----
L
R
I
C
A
R
D
K
E
V
G
N
L
Y
D
M
F
H
T
R
N
S
L
H
R
R
A
Y
Q
H
K
V
G
N
I
I
D
T
M
I
T
D
A
F
L
K
A
----
D
D
Y
-
I
-
E
I
T
G
A
G
G
K
K
Y
--------
R
I
S
----------
T
A
I
D
D
M
E
A
Y
T
K
L
T
D
N
I
F
L
E
I
L
Y
S
T
D
P
K
L
K
D
A
--
R
E
I
L
K
Q
I
E
Y
R
N
L
F
K
Y
V
------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
46.08
40%
-28
- C3 -
2HEK
12
?
A:
[3-239]
-----------
K
E
F
S
D
P
L
Y
G
F
V
R
V
G
E
A
G
L
-
R
L
I
D
S
F
P
F
Q
R
L
R
Y
V
K
Q
L
G
L
A
Y
L
V
F
P
S
A
Q
H
T
R
F
E
H
S
L
G
V
Y
H
I
T
E
R
I
C
E
S
L
------------------------
K
V
K
E
K
E
-
L
V
K
L
-
A
G
L
L
H
D
L
G
H
P
P
F
S
H
T
T
E
------------------
V
--
L
L
P
R
------
E
--
R
S
H
E
D
F
T
E
R
V
--------
I
-
K
-
E
---
T
E
I
Y
E
I
L
K
Q
D
YS
H
E
D
I
E
R
L
V
R
-
I
T
L
---
G
K
P
E
D
E
E
E
---------------------
K
--------
L
L
S
E
I
I
T
G
---
E
F
G
S
D
R
M
D
Y
L
R
R
D
A
Y
F
C
G
V
S
Y
G
F
F
D
Y
D
R
L
I
S
T
L
R
----
V
Y
E
----
N
K
V
V
V
D
E
S
G
L
R
A
L
E
N
F
L
I
S
R
Y
F
M
Y
V
Q
V
Y
F
H
K
V
V
R
I
L
S
I
H
L
V
E
F
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
43.78
40%
-27
- C3 -
2HEK
15
?
B:
[3-239]
-----------
K
E
F
S
D
P
L
Y
G
F
V
R
V
G
E
A
G
L
-
R
L
I
D
S
F
P
F
Q
R
L
R
Y
V
K
Q
L
G
L
A
Y
L
V
F
P
S
A
Q
H
T
R
F
E
H
S
L
G
V
Y
H
I
T
E
R
I
C
E
S
L
------------------------
K
V
K
E
K
E
-
L
V
K
L
-
A
G
L
L
H
D
L
G
H
P
P
F
S
H
T
T
E
------------------
V
--
L
L
PR------
E
--
R
S
H
E
D
F
T
E
R
V
--------
I
-
K
-
E
---
T
E
I
Y
E
I
L
K
QDYSHEDIERLV
R
-
I
T
L
---
G
K
P
E
D
E
E
E
---------------------
K
--------
L
L
S
E
I
I
T
G
---
E
F
G
S
D
R
M
D
Y
L
R
R
D
A
Y
F
C
G
V
S
Y
G
F
F
D
Y
D
R
L
I
S
T
L
R
----
V
Y
E
----
N
K
V
V
V
D
E
S
G
L
R
A
L
E
N
F
L
I
S
R
Y
F
M
Y
V
Q
V
Y
F
H
K
V
V
R
I
L
S
I
H
L
V
E
F
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
22.86
32%
-91
- C3 -
4MLM
5
?
A:
[23-90]
----------------------------------------------------
D
Y
I
G
E
A
I
N
Q
L
E
H
S
L
Q
C
A
Y
F
A
Q
R
S
G
A
D
------------------------------
N
-
E
M
V
L
-
A
A
L
L
H
D
L
G
H
Y
C
N
D
T
S
F
E
------------------
D
--
M
G
GYG-----
V
--
W
Q
H
E
K
V
G
A
D
Y
--------
L
R
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------