@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu37790: (2016-08-02 )
MSAKQVSKDEEKEALNLFLSTQTIIKEALRKLGYPGDMYELMKEPQRMLTVRIPVKMDNGSVKVFTGYRSQHNDAVGPTKGGVRFHPEVNEEEVKALSIWMTLKCGIANLPYGGGKGGIICDPRTMSFGELERLSRGYVRAISQIVGPTKDIPAPDVYTNSQIMAWMMDEYSRLREFDSPGFITGKPLVLGGSQGRETATAQGVTICIEEAVKKKGIKLQNARIIIQGFGNAGSFLAKFMHDAGAKVIGISDANGGLYNPDGLDIPYLLDKRDSFGMVTNLFTDVITNEELLEKDCDILVPAAISNQITAKNAHNIQASIVVEAANGPTTIDATKILNERGVLLVPDILASAGGVTVSYFEWVQNNQGYYWSEEEVAEKLRSVMVSSFETIYQTAATHKVDMRLAAYMTGIRKSAEASRFRGWV
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240........250.......260.......270....-...280..-----......290..-.....300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......-400.......410.......420..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
S
A
K
QVS
K
D
E
E
K
E
A
L
N
L
F
L
S
T
Q
T
I
I
K
E
A
L
R
KLGYPG
D
M
Y
E
L
M
KEPQ
R
M
L
T
V
R
I
P
V
K
MDNG
S
V
K
V
F
T
GYRSQHNDAVGPTKG
G
V
R
FHPEV
N
E
E
E
V
K
A
L
S
I
W
M
T
L
KCGIANLPYGGGKG
G
I
I
CDPRTM
S
F
G
E
L
E
R
L
S
R
G
Y
V
R
A
I
S
Q
IVGPTKDIPAPDVYT
N
S
Q
I
M
A
W
M
M
D
E
Y
S
R
L
R
EFDSPGFITGK
P
L
V
L
GGSQGRETATAQ
G
V
T
I
C
I
E
E
A
V
K
KKG
I
K
LQN
A
R
I
I
I
Q
GFG
N
A
G
S
F
L
A
K
F
M
H
-DAG
A
K
V
I
G
I
SDANGGLYNPDGLDI
P
Y
LLDKRDSF
G
-
M
V
T
N
L
-
F
T
-----
D
VIT
N
E
E
L
L
E
K-DC
D
I
L
V
PAAISNQITAKNAHN
I
Q
A
S
I
V
V
E
AANGPTT
I
D
A
T
K
I
LNERG
V
L
L
V
P
D
I
L
ASAG
G
V
T
V
S
Y
F
E
W
V
QNNQG
Y
Y
W
S
E
E
E
V
A
E
K
L
R
S
V
M
V
S
S
F
E
T
I
Y
Q
T
AATH
K
-
V
D
M
R
L
A
A
Y
M
T
G
I
RKSA
E
A
S
R
FRGWV
117
HHSearch
95.38
100%
-83
- C7 -
3K92
1
DHE2_BACSU
A:
[7-424]
------
S
K
D
E
E
K
E
A
L
N
L
F
L
S
T
Q
T
I
I
K
E
A
L
R
K
L
G
Y
P
G
D
M
Y
E
L
M
K
E
P
Q
R
M
L
T
V
R
I
P
V
K
M
D
N
G
S
V
K
V
F
T
G
Y
R
S
Q
H
N
D
A
V
G
P
T
K
G
G
V
R
F
H
P
E
V
N
E
E
K
V
K
A
L
S
I
W
M
T
L
K
C
G
I
A
N
L
P
Y
G
G
G
K
G
G
I
I
C
D
P
R
T
M
S
F
G
E
L
E
R
L
S
R
G
Y
V
R
A
I
S
Q
I
V
G
P
T
K
D
I
P
A
P
D
V
Y
T
N
S
Q
I
M
A
W
M
M
D
E
Y
S
R
L
R
E
F
D
S
P
G
F
I
T
G
K
P
L
V
L
G
G
S
Q
G
R
E
T
A
T
A
Q
G
V
T
I
C
I
E
E
A
V
K
K
K
G
I
K
L
Q
N
A
R
I
I
I
Q
G
F
G
N
A
G
S
F
L
A
K
F
M
H
-
D
A
G
A
K
V
I
G
I
S
D
A
N
G
G
L
Y
N
P
D
G
L
D
I
P
Y
L
L
D
K
R
D
S
F
G
-
M
V
T
N
L
-
F
T
-----
D
V
I
T
N
E
E
L
L
E
K
-
D
C
D
I
L
V
P
A
A
I
S
N
Q
I
T
A
K
N
A
H
N
I
Q
A
S
I
V
V
E
R
A
N
G
P
T
T
I
D
A
T
K
I
L
N
E
R
G
V
L
L
V
P
D
I
L
A
S
A
G
G
V
T
V
S
Y
F
E
W
V
Q
N
N
Q
G
Y
Y
W
S
E
E
E
V
A
E
K
L
R
S
V
M
V
S
S
F
E
T
I
Y
Q
T
A
A
T
H
K
-
V
D
M
R
L
A
A
Y
M
T
G
I
R
K
S
A
E
A
S
R
F
R
G
W
V
1
PsiBlast_PDB
95.17
99%
-83
- C7 -
3K92
1
DHE2_BACSU
A:
[7-424]
------
S
K
D
E
E
K
E
A
L
N
L
F
L
S
T
Q
T
I
I
K
E
A
L
R
K
L
G
Y
P
G
D
M
Y
E
L
M
K
E
P
Q
R
M
L
T
V
R
I
P
V
K
M
D
N
G
S
V
K
V
F
T
G
Y
R
S
Q
H
N
D
A
V
G
P
T
K
G
G
V
R
F
H
P
E
V
N
E
E
K
V
K
A
L
S
I
W
M
T
L
K
C
G
I
A
N
L
P
Y
G
G
G
K
G
G
I
I
C
D
P
R
T
M
S
F
G
E
L
E
R
L
S
R
G
Y
V
R
A
I
S
Q
I
V
G
P
T
K
D
I
P
A
P
D
V
Y
T
N
S
Q
I
M
A
W
M
M
D
E
Y
S
R
L
R
E
F
D
S
P
G
F
I
T
G
K
P
L
V
L
G
G
S
Q
G
R
E
T
A
T
A
Q
G
V
T
I
C
I
E
E
A
V
K
K
K
G
I
K
L
Q
N
A
R
I
I
I
Q
G
F
G
N
A
G
S
F
L
A
K
F
M
H
-
D
A
G
A
K
V
I
G
I
S
D
A
N
G
G
L
Y
N
P
D
G
L
D
I
P
Y
L
L
D
K
R
D
S
F
G
-
M
V
T
N
L
-
F
T
-----
D
V
I
T
N
E
E
L
L
E
K
-
D
C
D
I
L
V
P
A
A
I
S
N
Q
I
T
A
K
N
A
H
N
I
Q
A
S
I
V
V
E
R
A
N
G
P
T
T
I
D
A
T
K
I
L
N
E
R
G
V
L
L
V
P
D
I
L
A
S
A
G
G
V
T
V
S
Y
F
E
W
V
Q
N
N
Q
G
Y
Y
W
S
E
E
E
V
A
E
K
L
R
S
V
M
V
S
S
F
E
T
I
Y
Q
T
A
A
T
H
K
-
V
D
M
R
L
A
A
Y
M
T
G
I
R
K
S
A
E
A
S
R
F
R
G
W
V
23
PsiBlast_CBE
94.96
99%
-86
- C7 -
3K92
1
DHE2_BACSU
D:
[16-424]
---------------
N
L
F
L
S
T
Q
T
I
I
K
E
A
L
R
K
L
G
Y
P
G
D
M
Y
E
L
M
K
E
P
Q
R
M
L
T
V
R
I
P
V
K
M
D
N
G
S
V
K
V
F
T
G
Y
R
S
Q
H
N
D
A
V
G
P
T
K
G
G
V
R
F
H
P
E
V
N
E
E
K
V
K
A
L
S
I
W
M
T
L
K
C
G
I
A
N
L
P
Y
G
G
G
K
G
G
I
I
C
D
P
R
T
M
S
F
G
E
L
E
R
L
S
R
G
Y
V
R
A
I
S
Q
I
V
G
P
T
K
D
I
P
A
P
D
V
Y
T
N
S
Q
I
M
A
W
M
M
D
E
Y
S
R
L
R
E
F
D
S
P
G
F
I
T
G
K
P
L
V
L
G
G
S
Q
G
R
E
T
A
T
A
Q
G
V
T
I
C
I
E
E
A
V
K
K
K
G
I
K
L
Q
N
A
R
I
I
I
Q
G
F
G
N
A
G
S
F
L
A
K
F
M
H
-
D
A
G
A
K
V
I
G
I
S
D
A
N
G
G
L
Y
N
P
D
G
L
D
I
P
Y
L
L
D
K
R
D
----
M
V
T
N
L
-
F
T
-----
D
V
I
T
N
E
E
L
L
E
K
-
D
C
D
I
L
V
P
A
A
I
S
N
Q
I
T
A
K
N
A
H
N
I
Q
A
S
I
V
V
E
R
A
N
G
P
T
T
I
D
A
T
K
I
L
N
E
R
G
V
L
L
V
P
D
I
L
A
S
A
G
G
V
T
V
S
Y
F
E
W
V
Q
N
N
Q
G
Y
Y
W
S
E
E
E
V
A
E
K
L
R
S
V
M
V
S
S
F
E
T
I
Y
Q
T
A
A
T
H
K
-
V
D
M
R
L
A
A
Y
M
T
G
I
R
K
S
A
E
A
S
R
F
R
G
W
V
24
PsiBlast_CBE
94.00
99%
-84
- C7 -
3K92
1
DHE2_BACSU
C:
[16-424]
---------------
N
L
F
L
S
T
Q
T
I
I
K
E
A
L
R
K
L
G
Y
P
G
D
M
Y
E
L
M
K
E
P
Q
R
M
L
T
V
R
I
P
V
K
M
D
N
G
S
V
K
V
F
T
G
Y
R
S
Q
H
N
D
A
V
G
P
T
K
G
G
V
R
F
H
P
E
V
N
E
E
K
V
K
A
L
S
I
W
M
T
L
K
C
G
I
A
N
L
P
Y
G
G
G
K
G
G
I
I
C
D
P
R
T
M
S
F
G
E
L
E
R
L
S
R
G
Y
V
R
A
I
S
Q
I
V
G
P
T
K
D
I
P
A
P
D
V
Y
T
N
S
Q
I
M
A
W
M
M
D
E
Y
S
R
L
R
E
F
D
S
P
G
F
I
T
G
K
P
L
V
L
G
G
S
Q
G
R
E
T
A
T
A
Q
G
V
T
I
C
I
E
E
A
V
K
K
K
G
I
K
L
Q
N
A
R
I
I
I
Q
G
F
G
N
A
G
S
F
L
A
K
F
M
H
-
D
A
G
A
K
V
I
G
I
S
D
A
N
G
G
L
Y
N
P
D
G
L
D
I
P
Y
L
L
D
K
R
D
S
F
G
-
M
V
T
N
L
-
F
T
-----
D
V
I
T
N
E
E
L
L
E
K
-
D
C
D
I
L
V
P
A
A
I
S
N
Q
I
T
A
K
N
A
H
N
I
Q
A
S
I
V
V
E
R
A
N
G
P
T
T
I
D
A
T
K
I
L
N
E
R
G
V
L
L
V
P
D
I
L
A
S
A
G
G
V
T
V
S
Y
F
E
W
V
Q
N
N
Q
G
Y
Y
W
S
E
E
E
V
A
E
K
L
R
S
V
M
V
S
S
F
E
T
I
Y
Q
T
A
A
T
H
K
-
V
D
M
R
L
A
A
Y
M
T
G
I
R
K
S
A
E
A
S
R
F
R
G
W
V
22
PsiBlast_CBE
91.32
99%
-83
- C7 -
3K92
1
DHE2_BACSU
E:
[12-424]
-----------
K
E
A
L
N
L
F
L
S
T
Q
T
I
I
K
E
A
L
R
K
L
G
Y
P
G
D
M
Y
E
L
M
K
E
P
Q
R
M
L
T
V
R
I
P
V
K
M
D
N
G
S
V
K
V
F
T
G
Y
R
S
Q
H
N
D
A
V
G
P
T
K
G
G
V
R
F
H
P
E
V
N
E
E
K
V
K
A
L
S
I
W
M
T
L
K
C
G
I
A
N
L
P
Y
G
G
G
K
G
G
I
I
C
D
P
R
T
M
S
F
G
E
L
E
R
L
S
R
G
Y
V
R
A
I
S
Q
I
V
G
P
T
K
D
I
P
A
P
D
V
Y
T
N
S
Q
I
M
A
W
M
M
D
E
Y
S
R
L
R
E
F
D
S
P
G
F
I
T
G
K
P
L
V
L
G
G
S
Q
G
R
E
T
A
T
A
Q
G
V
T
I
C
I
E
E
A
V
K
K
K
G
I
K
L
Q
N
A
R
I
I
I
Q
G
F
G
N
A
G
S
F
L
A
K
F
M
H
-
D
A
G
A
K
V
I
G
I
S
D
A
N
G
G
L
Y
N
P
D
G
L
D
I
P
Y
L
L
------------------------
T
N
E
E
L
L
E
K
-
D
C
D
I
L
V
P
A
A
I
S
N
Q
I
T
A
K
N
A
H
N
I
Q
A
S
I
V
V
E
R
A
N
G
P
T
T
I
D
A
T
K
I
L
N
E
R
G
V
L
L
V
P
D
I
L
A
S
A
G
G
V
T
V
S
Y
F
E
W
V
Q
N
N
Q
G
Y
Y
W
S
E
E
E
V
A
E
K
L
R
S
V
M
V
S
S
F
E
T
I
Y
Q
T
A
A
T
H
K
-
V
D
M
R
L
A
A
Y
M
T
G
I
R
K
S
A
E
A
S
R
F
R
G
W
V
21
PsiBlast_CBE
90.92
99%
-84
- C7 -
3K92
1
DHE2_BACSU
F:
[14-424]
-------------
A
L
N
L
F
L
S
T
Q
T
I
I
K
E
A
L
R
K
L
G
Y
P
G
D
M
Y
E
L
M
K
E
P
Q
R
M
L
T
V
R
I
P
V
K
M
D
N
G
S
V
K
V
F
T
G
Y
R
S
Q
H
N
D
A
V
G
P
T
K
G
G
V
R
F
H
P
E
V
N
E
E
K
V
K
A
L
S
I
W
M
T
L
K
C
G
I
A
N
L
P
Y
G
G
G
K
G
G
I
I
C
D
P
R
T
M
S
F
G
E
L
E
R
L
S
R
G
Y
V
R
A
I
S
Q
I
V
G
P
T
K
D
I
P
A
P
D
V
Y
T
N
S
Q
I
M
A
W
M
M
D
E
Y
S
R
L
R
E
F
D
S
P
G
F
I
T
G
K
P
L
V
L
G
G
S
Q
G
R
E
T
A
T
A
Q
G
V
T
I
C
I
E
E
A
V
K
K
K
G
I
K
L
Q
N
A
R
I
I
I
Q
G
F
G
N
A
G
S
F
L
A
K
F
M
H
-
D
A
G
A
K
V
I
G
I
S
D
A
N
G
G
L
Y
N
P
D
G
L
D
I
P
Y
L
L
-----------------------
I
T
N
E
E
L
L
E
K
-
D
C
D
I
L
V
P
A
A
I
S
N
Q
I
T
A
K
N
A
H
N
I
Q
A
S
I
V
V
E
R
A
N
G
P
T
T
I
D
A
T
K
I
L
N
E
R
G
V
L
L
V
P
D
I
L
A
S
A
G
G
V
T
V
S
Y
F
E
W
V
Q
N
N
Q
G
Y
Y
W
S
E
E
E
V
A
E
K
L
R
S
V
M
V
S
S
F
E
T
I
Y
Q
T
A
A
T
H
K
-
V
D
M
R
L
A
A
Y
M
T
G
I
R
K
S
A
E
A
S
R
F
R
G
W
V
2
PsiBlast_PDB
85.50
75%
-95
- C7 -
3K8Z
-
GUDB_BACSU
A:
[17-423]
----------------
V
L
K
S
T
Q
T
V
I
H
K
A
L
E
K
L
G
Y
P
E
E
V
Y
E
L
L
K
E
P
M
R
L
L
T
V
K
I
P
V
R
M
D
D
G
S
V
K
I
F
T
G
Y
R
A
-
H
N
D
S
V
G
P
T
K
G
G
I
R
F
H
P
N
V
T
E
K
E
V
K
A
L
S
I
W
M
S
L
K
C
G
I
I
D
L
P
Y
G
G
G
K
G
G
I
V
C
D
P
R
D
M
S
F
R
E
L
E
R
L
S
R
G
Y
V
R
A
I
S
Q
I
V
G
P
T
K
D
V
P
A
P
D
V
F
T
N
S
Q
I
M
A
W
M
M
D
E
Y
S
R
I
D
E
F
N
S
P
G
F
I
T
G
K
P
L
V
L
G
G
S
H
G
R
E
S
A
T
A
K
G
V
T
I
C
I
K
E
A
A
K
K
R
G
I
D
I
K
G
A
R
V
V
V
Q
G
F
G
N
A
G
S
Y
L
A
K
F
M
H
-
D
A
G
A
K
V
V
G
I
S
D
A
Y
G
G
L
Y
D
P
E
G
L
D
I
D
-------------------------------------
C
D
I
L
V
P
A
A
I
E
N
Q
I
T
E
E
N
A
H
N
I
R
A
K
I
V
V
E
A
A
N
G
P
T
T
L
E
G
T
K
I
L
S
D
R
D
I
L
L
V
P
D
V
L
A
S
A
G
G
V
T
V
S
Y
F
E
W
V
Q
N
N
Q
G
F
Y
W
S
E
E
E
V
E
E
K
L
E
K
M
M
V
K
S
F
N
N
I
Y
E
M
A
N
N
R
R
-
I
D
M
R
L
A
A
Y
M
V
G
V
R
K
M
A
E
A
S
R
F
R
G
W
I
58
PsiBlast_CBE
76.32
36%
-103
- C7 -
3AOE
3
?
C:
[22-416]
------------------------
L
E
R
A
L
K
V
A
G
V
H
P
T
T
L
E
Y
L
A
H
P
K
R
L
V
T
L
S
L
P
V
V
M
D
D
G
K
V
R
I
F
Q
G
Y
R
V
V
H
D
I
A
R
G
P
A
K
G
G
V
R
L
D
P
G
V
T
L
G
Q
T
A
G
L
A
A
W
M
T
L
K
A
A
V
Y
D
L
P
F
G
G
A
A
G
G
I
A
V
D
P
K
G
L
S
P
Q
E
L
E
R
L
V
R
R
Y
T
A
E
L
V
G
L
I
G
P
D
S
D
I
L
G
P
D
L
G
A
D
Q
Q
V
M
A
W
I
M
D
T
Y
S
M
T
V
G
S
T
V
P
G
V
V
T
G
K
P
H
A
L
G
G
S
E
G
R
D
D
A
A
G
L
G
A
L
L
V
L
E
A
L
A
K
R
R
G
L
D
L
R
G
A
R
V
V
V
Q
G
L
G
Q
V
G
A
A
V
A
L
H
A
E
-
R
L
G
M
R
V
V
A
V
A
T
S
M
G
G
M
Y
A
P
E
G
L
D
V
A
E
V
L
S
A
Y
E
A
T
G
-
S
L
P
R
L
-
D
--------
L
A
P
E
E
V
F
G
L
-
E
A
E
V
L
V
L
A
A
R
E
G
A
L
D
G
D
R
A
R
Q
V
Q
A
Q
A
V
V
E
V
A
N
F
G
L
N
P
E
A
E
A
Y
L
L
G
K
G
A
L
V
V
P
D
L
L
S
G
G
G
G
L
L
A
S
Y
L
E
W
V
Q
D
L
N
M
F
F
W
S
P
E
E
V
R
E
R
F
E
T
R
V
A
R
V
V
D
A
V
C
R
R
A
E
R
G
G
-
L
D
L
R
M
G
A
L
A
L
A
L
E
R
L
D
E
A
T
R
L
R
G
--
119
HHSearch
75.94
36%
-103
- C7 -
3AOE
3
?
E:
[9-418]
-----------
P
E
D
P
G
L
W
D
T
Y
L
E
W
L
E
R
A
L
K
V
A
G
V
H
P
T
T
L
E
Y
L
A
H
P
K
R
L
V
T
L
S
L
P
V
V
M
D
D
G
K
V
R
I
F
Q
G
Y
R
V
V
H
D
I
A
R
G
P
A
K
G
G
V
R
L
D
P
G
V
T
L
G
Q
T
A
G
L
A
A
W
M
T
L
K
A
A
V
Y
D
L
P
F
G
G
A
A
G
G
I
A
V
D
P
K
G
L
S
P
Q
E
L
E
R
L
V
R
R
Y
T
A
E
L
V
G
L
I
G
P
D
S
D
I
L
G
P
D
L
G
A
D
Q
Q
V
M
A
W
I
M
D
T
Y
S
M
T
V
G
S
T
V
P
G
V
V
T
G
K
P
H
A
L
G
G
S
E
G
R
D
D
A
A
G
L
G
A
L
L
V
L
E
A
L
A
K
R
R
G
L
D
L
R
G
A
R
V
V
V
Q
G
L
G
Q
V
G
A
A
V
A
L
H
A
E
-
R
L
G
M
R
V
V
A
V
A
T
S
M
G
G
M
Y
A
P
E
G
L
D
V
A
E
V
L
S
A
Y
E
A
T
G
-
S
L
P
R
L
---------
D
L
A
P
E
E
V
F
G
L
-
E
A
E
V
L
V
L
A
A
R
E
G
A
L
D
G
D
R
A
R
Q
V
Q
A
Q
A
V
V
E
V
A
N
F
G
L
N
P
E
A
E
A
Y
L
L
G
K
G
A
L
V
V
P
D
L
L
S
G
G
G
G
L
L
A
S
Y
L
E
W
V
Q
D
L
N
M
F
F
W
S
P
E
E
V
R
E
R
F
E
T
R
V
A
R
V
V
D
A
V
C
R
R
A
E
R
G
G
-
L
D
L
R
M
G
A
L
A
L
A
L
E
R
L
D
E
A
T
R
L
R
G
V
Y
56
PsiBlast_CBE
75.34
36%
-106
- C7 -
3AOE
3
?
E:
[22-416]
------------------------
L
E
R
A
L
K
V
A
G
V
H
P
T
T
L
E
Y
L
A
H
P
K
R
L
V
T
L
S
L
P
V
V
M
D
D
G
K
V
R
I
F
Q
G
Y
R
V
V
H
D
I
A
R
G
P
A
K
G
G
V
R
L
D
P
G
V
T
L
G
Q
T
A
G
L
A
A
W
M
T
L
K
A
A
V
Y
D
L
P
F
G
G
A
A
G
G
I
A
V
D
P
K
G
L
S
P
Q
E
L
E
R
L
V
R
R
Y
T
A
E
L
V
G
L
I
G
P
D
S
D
I
L
G
P
D
L
G
A
D
Q
Q
V
M
A
W
I
M
D
T
Y
S
M
T
V
G
S
T
V
P
G
V
V
T
G
K
P
H
A
L
G
G
S
E
G
R
D
D
A
A
G
L
G
A
L
L
V
L
E
A
L
A
K
R
R
G
L
D
L
R
G
A
R
V
V
V
Q
G
L
G
Q
V
G
A
A
V
A
L
H
A
E
-
R
L
G
M
R
V
V
A
V
A
T
S
M
G
G
M
Y
A
P
E
G
L
D
V
A
E
V
L
S
A
Y
E
A
T
G
-
S
L
P
R
L
-
D
--------
L
A
P
E
E
V
F
G
L
-
E
A
E
V
L
V
L
A
A
R
E
G
A
L
D
G
D
R
A
R
Q
V
Q
A
Q
A
V
V
E
V
A
N
F
G
L
N
P
E
A
E
A
Y
L
L
G
K
G
A
L
V
V
P
D
L
L
S
G
G
G
G
L
L
A
S
Y
L
E
W
V
Q
D
L
N
M
F
F
W
S
P
E
E
V
R
E
R
F
E
T
R
V
A
R
V
V
D
A
V
C
R
R
A
E
R
G
G
-
L
D
L
R
M
G
A
L
A
L
A
L
E
R
L
D
E
A
T
R
L
R
G
--
55
PsiBlast_CBE
75.09
36%
-104
- C7 -
3AOE
3
?
F:
[22-416]
------------------------
L
E
R
A
L
K
V
A
G
V
H
P
T
T
L
E
Y
L
A
H
P
K
R
L
V
T
L
S
L
P
V
V
M
D
D
G
K
V
R
I
F
Q
G
Y
R
V
V
H
D
I
A
R
G
P
A
K
G
G
V
R
L
D
P
G
V
T
L
G
Q
T
A
G
L
A
A
W
M
T
L
K
A
A
V
Y
D
L
P
F
G
G
A
A
G
G
I
A
V
D
P
K
G
L
S
P
Q
E
L
E
R
L
V
R
R
Y
T
A
E
L
V
G
L
I
G
P
D
S
D
I
L
G
P
D
L
G
A
D
Q
Q
V
M
A
W
I
M
D
T
Y
S
M
T
V
G
S
T
V
P
G
V
V
T
G
K
P
H
A
L
G
G
S
E
G
R
D
D
A
A
G
L
G
A
L
L
V
L
E
A
L
A
K
R
R
G
L
D
L
R
G
A
R
V
V
V
Q
G
L
G
Q
V
G
A
A
V
A
L
H
A
E
-
R
L
G
M
R
V
V
A
V
A
T
S
M
G
G
M
Y
A
P
E
G
L
D
V
A
E
V
L
S
A
Y
E
A
T
G
-
S
L
P
R
L
-
D
--------
L
A
P
E
E
V
F
G
L
-
E
A
E
V
L
V
L
A
A
R
E
G
A
L
D
G
D
R
A
R
Q
V
Q
A
Q
A
V
V
E
V
A
N
F
G
L
N
P
E
A
E
A
Y
L
L
G
K
G
A
L
V
V
P
D
L
L
S
G
G
G
G
L
L
A
S
Y
L
E
W
V
Q
D
L
N
M
F
F
W
S
P
E
E
V
R
E
R
F
E
T
R
V
A
R
V
V
D
A
V
C
R
R
A
E
R
G
G
-
L
D
L
R
M
G
A
L
A
L
A
L
E
R
L
D
E
A
T
R
L
R
G
--
57
PsiBlast_CBE
74.16
36%
-103
- C7 -
3AOE
3
?
D:
[22-416]
------------------------
L
E
R
A
L
K
V
A
G
V
H
P
T
T
L
E
Y
L
A
H
P
K
R
L
V
T
L
S
L
P
V
V
M
D
D
G
K
V
R
I
F
Q
G
Y
R
V
V
H
D
I
A
R
G
P
A
K
G
G
V
R
L
D
P
G
V
T
L
G
Q
T
A
G
L
A
A
W
M
T
L
K
A
A
V
Y
D
L
P
F
G
G
A
A
G
G
I
A
V
D
P
K
G
L
S
P
Q
E
L
E
R
L
V
R
R
Y
T
A
E
L
V
G
L
I
G
P
D
S
D
I
L
G
P
D
L
G
A
D
Q
Q
V
M
A
W
I
M
D
T
Y
S
M
T
V
G
S
T
V
P
G
V
V
T
G
K
P
H
A
L
G
G
S
E
G
R
D
D
A
A
G
L
G
A
L
L
V
L
E
A
L
A
K
R
R
G
L
D
L
R
G
A
R
V
V
V
Q
G
L
G
Q
V
G
A
A
V
A
L
H
A
E
-
R
L
G
M
R
V
V
A
V
A
T
S
M
G
G
M
Y
A
P
E
G
L
D
V
A
E
V
L
S
A
Y
E
A
T
G
-
S
L
P
R
L
-
D
--------
L
A
P
E
E
V
F
G
L
-
E
A
E
V
L
V
L
A
A
R
E
G
A
L
D
G
D
R
A
R
Q
V
Q
A
Q
A
V
V
E
V
A
N
F
G
L
N
P
E
A
E
A
Y
L
L
G
K
G
A
L
V
V
P
D
L
L
S
G
G
G
G
L
L
A
S
Y
L
E
W
V
Q
D
L
N
M
F
F
W
S
P
E
E
V
R
E
R
F
E
T
R
V
A
R
V
V
D
A
V
C
R
R
A
E
R
G
G
-
L
D
L
R
M
G
A
L
A
L
A
L
E
R
L
D
E
A
T
R
L
R
G
--
115
HHSearch
71.73
47%
-49
- C7 -
3AOG
4
?
A:
[27-439]
------------
K
D
G
G
P
W
E
I
F
T
E
Q
V
D
R
V
V
P
Y
L
G
R
L
A
P
L
A
E
S
L
K
R
P
K
R
V
L
I
V
D
V
P
V
R
L
D
D
G
S
V
A
Y
F
E
G
Y
R
V
H
H
N
T
A
R
G
P
A
K
G
G
V
R
Y
H
P
E
V
T
L
S
E
V
M
A
L
A
G
W
M
T
I
K
N
A
A
V
G
L
P
Y
G
G
G
K
G
G
I
R
V
D
P
R
K
L
S
P
G
E
L
E
R
L
T
R
R
Y
T
S
E
I
G
I
L
L
G
P
D
R
D
I
P
A
P
D
V
N
T
G
E
R
E
M
A
W
M
M
D
T
Y
S
M
N
V
G
R
T
V
P
G
V
V
T
G
K
P
I
A
L
G
G
S
L
G
R
R
D
A
T
G
R
G
V
F
I
T
A
A
A
A
A
E
K
I
G
L
Q
V
E
G
A
R
V
A
I
Q
G
F
G
N
V
G
N
A
A
A
R
A
F
H
-
D
H
G
A
R
V
V
A
V
Q
D
H
T
G
T
V
Y
N
E
A
G
I
D
P
Y
D
L
L
R
H
V
Q
E
F
G
-
G
V
R
G
Y
-
P
K
A
----
E
P
L
P
A
A
D
F
W
G
L
-
P
V
E
F
L
V
P
A
A
L
E
K
Q
I
T
E
Q
N
A
W
R
I
R
A
R
I
V
A
E
G
A
N
G
P
T
T
P
A
A
D
D
I
L
L
E
K
G
V
L
V
V
P
D
V
I
A
N
A
G
G
V
T
V
S
Y
F
E
W
V
Q
D
F
N
S
Y
F
W
T
E
E
E
I
N
A
R
L
E
R
V
L
R
N
A
F
E
A
V
W
Q
V
A
Q
E
K
K
-
I
P
L
R
T
A
A
Y
V
V
A
A
T
R
V
L
E
A
R
A
L
R
G
L
Y
41
PsiBlast_CBE
71.29
46%
-43
- C7 -
1V9L
1
?
C:
[14-421]
------------------------
V
K
K
G
V
E
L
G
G
F
P
E
D
F
Y
K
I
L
S
R
P
R
R
V
L
I
V
N
I
P
V
R
L
D
G
G
G
F
E
V
F
E
G
Y
R
V
Q
H
C
D
V
L
G
P
Y
K
G
G
V
R
F
H
P
E
V
T
L
A
D
D
V
A
L
A
I
L
M
T
L
K
N
S
L
A
G
L
P
Y
G
G
A
K
G
A
V
R
V
D
P
K
K
L
S
Q
R
E
L
E
E
L
S
R
G
Y
A
R
A
I
A
P
L
I
G
D
V
V
D
I
P
A
P
D
V
G
T
N
A
Q
I
M
A
W
M
V
D
E
Y
S
K
I
K
G
Y
N
V
P
G
V
F
T
S
K
P
P
E
L
W
G
N
P
V
R
E
Y
A
T
G
F
G
V
A
V
A
T
R
E
M
A
K
K
L
W
G
G
I
E
G
K
T
V
A
I
Q
G
M
G
N
V
G
R
W
T
A
Y
W
L
E
-
K
M
G
A
K
V
I
A
V
S
D
I
N
G
V
A
Y
R
K
E
G
L
N
V
E
L
I
Q
K
N
K
G
L
T
G
P
A
L
V
E
L
-
F
T
TKDNA
E
F
V
K
N
P
D
A
I
F
K
L
D
V
D
I
F
V
P
A
A
I
E
N
V
I
R
G
D
N
A
G
L
V
K
A
R
L
V
V
E
G
A
N
G
P
T
T
P
E
A
E
R
I
L
Y
E
R
G
V
V
V
V
P
D
I
L
A
N
A
G
G
V
I
M
S
Y
L
E
W
V
E
N
L
Q
W
Y
I
W
D
E
E
E
T
R
K
R
L
E
N
I
M
V
N
N
V
E
R
V
Y
K
R
W
Q
R
E
K
G
W
T
M
R
D
A
A
I
V
T
A
L
E
R
I
Y
N
A
M
K
I
R
G
W
I
114
HHSearch
71.04
46%
-44
- C7 -
4XGI
3
?
A:
[22-435]
-----------
A
D
D
L
G
P
W
G
N
Y
L
Q
Q
V
D
R
V
A
P
Y
L
G
S
L
S
R
W
I
E
T
L
K
R
P
K
R
I
L
I
V
D
V
P
I
E
L
D
N
G
T
V
A
H
F
E
G
Y
R
V
Q
H
N
V
S
R
G
P
G
K
G
G
V
R
Y
H
Q
D
V
T
L
S
E
V
M
A
L
S
A
W
M
S
V
K
N
A
A
V
N
V
P
Y
G
G
A
K
G
G
I
R
V
D
P
R
K
L
S
R
G
E
L
E
R
V
T
R
R
Y
T
S
E
I
G
I
I
I
G
P
N
T
D
I
P
A
P
D
V
N
T
N
E
Q
I
M
A
W
M
M
D
T
Y
S
M
N
Q
G
Q
T
A
T
G
V
V
T
G
K
P
I
S
L
G
G
S
L
G
R
K
E
A
T
G
R
G
V
F
V
V
G
C
E
A
A
K
K
K
G
V
E
I
E
G
A
R
I
A
V
Q
G
F
G
N
V
G
G
I
A
A
K
L
F
Q
-
E
A
G
A
K
V
I
A
V
Q
D
H
T
G
T
I
H
Q
P
A
G
V
D
T
A
K
L
L
D
H
V
G
R
T
G
-
G
V
A
G
F
-
E
G
A
----
E
P
M
P
N
D
E
F
W
T
V
-
E
T
E
I
L
I
P
A
A
L
E
N
Q
I
T
E
K
N
A
S
K
I
R
T
K
I
I
V
E
G
A
N
G
P
T
T
T
A
A
D
D
I
L
S
A
N
G
V
L
V
I
P
D
V
I
A
N
A
G
G
V
T
V
S
Y
F
E
W
V
Q
------
W
T
E
D
E
I
N
H
R
L
E
R
V
M
R
E
A
F
A
G
V
W
A
V
A
E
E
H
K
-
V
S
V
R
T
A
A
F
I
V
A
C
K
R
I
L
M
A
R
E
M
R
G
L
Y
39
PsiBlast_CBE
70.38
46%
-41
- C7 -
1V9L
1
?
E:
[14-421]
------------------------
V
K
K
G
V
E
L
G
G
F
P
E
D
F
Y
K
I
L
S
R
P
R
R
V
L
I
V
N
I
P
V
R
L
D
G
G
G
F
E
V
F
E
G
Y
R
V
Q
H
C
D
V
L
G
P
Y
K
G
G
V
R
F
H
P
E
V
T
L
A
D
D
V
A
L
A
I
L
M
T
L
K
N
S
L
A
G
L
P
Y
G
G
A
K
G
A
V
R
V
D
P
K
K
L
S
Q
R
E
L
E
E
L
S
R
G
Y
A
R
A
I
A
P
L
I
G
D
V
V
D
I
P
A
P
D
V
G
T
N
A
Q
I
M
A
W
M
V
D
E
Y
S
K
I
K
G
Y
N
V
P
G
V
F
T
S
K
P
P
E
L
W
G
N
P
V
R
E
Y
A
T
G
F
G
V
A
V
A
T
R
E
M
A
K
K
L
W
G
G
I
E
G
K
T
V
A
I
Q
G
M
G
N
V
G
R
W
T
A
Y
W
L
E
-
K
M
G
A
K
V
I
A
V
S
D
I
N
G
V
A
Y
R
K
E
G
L
N
V
E
L
I
Q
K
N
K
G
L
T
G
P
A
L
V
E
L
-
F
T
TKDNA
E
F
V
K
N
P
D
A
I
F
K
L
D
V
D
I
F
V
P
A
A
I
E
N
V
I
R
G
D
N
A
G
L
V
K
A
R
L
V
V
E
G
A
N
G
P
T
T
P
E
A
E
R
I
L
Y
E
R
G
V
V
V
V
P
D
I
L
A
N
A
G
G
V
I
M
S
Y
L
E
W
V
E
N
L
Q
W
Y
I
W
D
E
E
E
T
R
K
R
L
E
N
I
M
V
N
N
V
E
R
V
Y
K
R
W
Q
R
E
K
G
W
T
M
R
D
A
A
I
V
T
A
L
E
R
I
Y
N
A
M
K
I
R
G
W
I
116
HHSearch
69.96
48%
-24
* C7 *
2TMG
-
DHE3_THEMA
A:
[4-411]
---------------
S
L
Y
E
M
A
V
E
Q
F
N
R
A
A
S
L
M
D
L
E
S
D
L
A
E
V
L
R
R
P
K
R
V
L
I
V
E
F
P
V
R
M
D
D
G
H
V
E
V
F
T
G
Y
R
V
Q
H
N
V
A
R
G
P
A
K
G
G
I
R
Y
H
P
D
V
T
L
D
E
V
K
A
L
A
F
W
M
T
W
K
T
A
V
M
N
L
P
F
G
G
G
K
G
G
V
R
V
D
P
K
K
L
S
R
R
E
L
E
R
L
S
R
R
F
F
R
E
I
Q
V
I
I
G
P
Y
N
D
I
P
A
P
D
V
N
T
N
A
D
V
I
A
W
Y
M
D
E
Y
E
M
N
V
G
H
T
V
L
G
I
V
T
G
K
P
V
E
L
G
G
S
K
G
R
E
E
A
T
G
R
G
V
K
V
C
A
G
L
A
M
D
V
L
G
I
D
P
K
K
A
T
V
A
V
Q
G
F
G
N
V
G
Q
F
A
A
L
L
I
S
Q
E
L
G
S
K
V
V
A
V
S
D
S
R
G
G
I
Y
N
P
E
G
F
D
V
E
E
L
I
R
Y
K
K
E
H
G
-
T
V
V
T
Y
-
P
K
G
----
E
R
I
T
N
E
E
L
L
E
L
-
D
V
D
I
L
V
P
A
A
L
E
G
A
I
H
A
G
N
A
E
R
I
K
A
K
A
V
V
E
G
A
N
G
P
T
T
P
E
A
D
E
I
L
S
R
R
G
I
L
V
V
P
D
I
L
A
N
A
G
G
V
T
V
S
Y
F
E
W
V
Q
D
L
Q
S
F
F
W
D
L
D
Q
V
R
N
A
L
E
K
M
M
K
G
A
F
N
D
V
M
K
V
K
E
K
Y
N
-
V
D
M
R
T
A
A
Y
I
L
A
I
D
R
V
A
Y
A
T
K
K
R
---
40
PsiBlast_CBE
69.75
46%
-45
- C7 -
1V9L
1
?
D:
[14-421]
------------------------
V
K
K
G
V
E
L
G
G
F
P
E
D
F
Y
K
I
L
S
R
P
R
R
V
L
I
V
N
I
P
V
R
L
D
G
G
G
F
E
V
F
E
G
Y
R
V
Q
H
C
D
V
L
G
P
Y
K
G
G
V
R
F
H
P
E
V
T
L
A
D
D
V
A
L
A
I
L
M
T
L
K
N
S
L
A
G
L
P
Y
G
G
A
K
G
A
V
R
V
D
P
K
K
L
S
Q
R
E
L
E
E
L
S
R
G
Y
A
R
A
I
A
P
L
I
G
D
V
V
D
I
P
A
P
D
V
G
T
N
A
Q
I
M
A
W
M
V
D
E
Y
S
K
I
K
G
Y
N
V
P
G
V
F
T
S
K
P
P
E
L
W
G
N
P
V
R
E
Y
A
T
G
F
G
V
A
V
A
T
R
E
M
A
K
K
L
W
G
G
I
E
G
K
T
V
A
I
Q
G
M
G
N
V
G
R
W
T
A
Y
W
L
E
-
K
M
G
A
K
V
I
A
V
S
D
I
N
G
V
A
Y
R
K
E
G
L
N
V
E
L
I
Q
K
N
K
G
L
T
G
P
A
L
V
E
L
-
F
T
TKDNA
E
F
V
K
N
P
D
A
I
F
K
L
D
V
D
I
F
V
P
A
A
I
E
N
V
I
R
G
D
N
A
G
L
V
K
A
R
L
V
V
E
G
A
N
G
P
T
T
P
E
A
E
R
I
L
Y
E
R
G
V
V
V
V
P
D
I
L
A
N
A
G
G
V
I
M
S
Y
L
E
W
V
E
N
L
Q
W
Y
I
W
D
E
E
E
T
R
K
R
L
E
N
I
M
V
N
N
V
E
R
V
Y
K
R
W
Q
R
E
K
G
W
T
M
R
D
A
A
I
V
T
A
L
E
R
I
Y
N
A
M
K
I
R
G
W
I
11
PsiBlast_PDB
69.60
46%
-41
- C7 -
1V9L
1
?
A:
[14-421]
------------------------
V
K
K
G
V
E
L
G
G
F
P
E
D
F
Y
K
I
L
S
R
P
R
R
V
L
I
V
N
I
P
V
R
L
D
G
G
G
F
E
V
F
E
G
Y
R
V
Q
H
C
D
V
L
G
P
Y
K
G
G
V
R
F
H
P
E
V
T
L
A
D
D
V
A
L
A
I
L
M
T
L
K
N
S
L
A
G
L
P
Y
G
G
A
K
G
A
V
R
V
D
P
K
K
L
S
Q
R
E
L
E
E
L
S
R
G
Y
A
R
A
I
A
P
L
I
G
D
V
V
D
I
P
A
P
D
V
G
T
N
A
Q
I
M
A
W
M
V
D
E
Y
S
K
I
K
G
Y
N
V
P
G
V
F
T
S
K
P
P
E
L
W
G
N
P
V
R
E
Y
A
T
G
F
G
V
A
V
A
T
R
E
M
A
K
K
L
W
G
G
I
E
G
K
T
V
A
I
Q
G
M
G
N
V
G
R
W
T
A
Y
W
L
E
-
K
M
G
A
K
V
I
A
V
S
D
I
N
G
V
A
Y
R
K
E
G
L
N
V
E
L
I
Q
K
N
K
G
L
T
G
P
A
L
V
E
L
-
F
T
T
KDNA
E
F
V
K
N
P
D
A
I
F
K
L
D
V
D
I
F
V
P
A
A
I
E
N
V
I
R
G
D
N
A
G
L
V
K
A
R
L
V
V
E
G
A
N
G
P
T
T
P
E
A
E
R
I
L
Y
E
R
G
V
V
V
V
P
D
I
L
A
N
A
G
G
V
I
M
S
Y
L
E
W
V
E
N
L
Q
W
Y
I
W
D
E
E
E
T
R
K
R
L
E
N
I
M
V
N
N
V
E
R
V
Y
K
R
W
Q
R
E
K
G
W
T
M
R
D
A
A
I
V
T
A
L
E
R
I
Y
N
A
M
K
I
R
G
W
I
36
PsiBlast_CBE
69.52
48%
-50
- C7 -
4XGI
3
?
C:
[42-433]
-------------------------------
L
G
S
L
S
R
W
I
E
T
L
K
R
P
K
R
I
L
I
V
D
V
P
I
E
L
D
N
G
T
V
A
H
F
E
G
Y
R
V
Q
H
N
V
S
R
G
P
G
K
G
G
V
R
Y
H
Q
D
V
T
L
S
E
V
M
A
L
S
A
W
M
S
V
K
N
A
A
V
N
V
P
Y
G
G
A
K
G
G
I
R
V
D
P
R
K
L
S
R
G
E
L
E
R
V
T
R
R
Y
T
S
E
I
G
I
I
I
G
P
N
T
D
I
P
A
P
D
V
N
T
N
E
Q
I
M
A
W
M
M
D
T
Y
S
M
N
Q
G
Q
T
A
T
G
V
V
T
G
K
P
I
S
L
G
G
S
L
G
R
K
E
A
T
G
R
G
V
F
V
V
G
C
E
A
A
K
K
K
G
V
E
I
E
G
A
R
I
A
V
Q
G
F
G
N
V
G
G
I
A
A
K
L
F
Q
-
E
A
G
A
K
V
I
A
V
Q
D
H
T
G
T
I
H
Q
P
A
G
V
D
T
A
K
L
L
D
H
V
G
R
T
G
-
G
V
A
G
F
E
G
A
-----
E
P
M
P
N
D
E
F
W
T
V
-
E
T
E
I
L
I
P
A
A
L
E
N
Q
I
T
E
K
N
A
S
K
I
R
T
K
I
I
V
E
G
A
N
G
P
T
T
T
A
A
D
D
I
L
S
A
N
G
V
L
V
I
P
D
V
I
A
N
A
G
G
V
T
V
S
Y
F
E
W
V
Q
------
W
T
E
D
E
I
N
H
R
L
E
R
V
M
R
E
A
F
A
G
V
W
A
V
A
E
E
H
K
-
V
S
V
R
T
A
A
F
I
V
A
C
K
R
I
L
M
A
R
E
M
R
G
--