@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu37870: (2016-08-03 )
MAAFQIANKTVGKDAPVFIIAEAGINHDGKLDQAFALIDAAAEAGADAVKFQMFQADRMYQKDPGLYKTAAGKDVSIFSLVQSMEMPAEWILPLLDYCREKQVIFLSTVCDEGSADLLQSTSPSAFKIASYEINHLPLLKYVARLNRPMIFSTAGAEISDVHEAWRTIRAEGNNQIAIMHCVAKYPAPPEYSNLSVIPMLAAAFPEAVIGFSDHSEHPTEAPCAAVRLGAKLIEKHFTIDKNLPGADHSFALNPDELKEMVDGIRKTEAELKQGITKPVSEKLLGSSYKTTTAIEGEIRNFAYRGIFTTAPIQKGEAFSEDNIAVLRPGQKPQGLHPRFFELLTSGVRAVRDIPADTGIVWDDILLKDSPFHE
Atome Classification :
(20 SA)
.........10........20.-......-.30........40...--..-----.---..50.-..-----...-..60........70...-.....80....-.-..-.90......-...100.......110.......120.......130.......140......-.150...-.-...160.....-..170.......-180.--.-...-...190......-.200.......210....-----..-..----220..-.-.....230.--........240.......250.......-260.......-270.......280.......290.....--..300.......310.......320.......330..-.....340...-....350.......-360.......370.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MA
A
F
Q
IANKTVGKDA
P
V
F
I
I
A
E-AGINHD-G
K
L
D
Q
A
F
A
L
I
D
A
A
A
EA--GA-----
D
---
A
V
K
F
Q
-
M
F
-----
Q
AD-
R
M
Y
QKDPG
L
Y
KTAAGK
D
-
V
S
I
F
S
L
V
Q
S
ME-M-
P
A
-
E
W
-
I
L
P
L
L
D
-
Y
CREK
Q
V
I
F
L
S
TVCDEG
S
A
D
L
L
QSTSPS
A
F
K
I
A
S
Y
E
IN
H
L
P
L
L
K
Y
V
A
R
LNR
P
-
M
I
F
STAG-A-
E
I
S
D
V
H
E
A
W
R
T
-
I
RAEGN
N
Q
I
A
I
M
-
H
-
C
V
--
A
-KYP-APPEYSNL
S
V
I
P
-
M
L
A
A
AF
P
E
A
VIGF-SDHS-----EH-PT----E-A
P
C
-
A
-
A
V
R
L
G
A
--
K
--
L
I
E
K
HFTIDKNLPGADHSFAL
N
P
D
E
L
K
E
-
M
V
D
G
I
R
K
T
E
A
-
E
L
K
QGITK
P
V
S
E
K
L
LGSSYKT
T
T
AIE
G
E
--
I
R
N
F
A
YRG
I
F
TTAPIQKGEAFSED
N
I
A
V
LRPGQKPQG-L
H
P
R
F
F
E
L
L
T
S
-
G
V
R
A
V
R
DIPADTG
I
-
V
W
DDILLKDSPFHE
1
PsiBlast_PDB
94.84
97%
-105
- C4 -
1VLI
1
SPSE_BACSU
A:
[14-380]
-
A
A
F
Q
I
A
N
K
T
V
G
K
D
A
P
V
F
I
I
A
E
-
A
G
I
N
H
D
-
G
K
L
D
Q
A
F
A
L
I
D
A
A
A
E
A
--
G
A
-----
D
---
A
V
K
F
Q
-
M
F
-----
Q
A
D
-
R
M
Y
Q
K
D
P
---------
D
-
V
S
I
F
S
L
V
Q
S
M
E
-
M
-
P
A
-
E
W
-
I
L
P
L
L
D
-
Y
C
R
E
K
Q
V
I
F
L
S
T
V
C
D
E
G
S
A
D
L
L
Q
S
T
S
P
S
A
F
K
I
A
S
Y
E
I
N
H
L
P
L
L
K
Y
V
A
R
L
N
R
P
-
M
I
F
S
T
A
G
-
A
-
E
I
S
D
V
H
E
A
W
R
T
-
I
R
A
E
G
N
N
Q
I
A
I
M
-
H
-
C
V
--
A
-
K
Y
P
-
A
P
P
E
Y
S
N
L
S
V
I
P
-
M
L
A
A
A
F
P
E
A
V
I
G
F
-
S
D
H
S
-----
E
H
-
P
T
----
E
-
A
P
C
-
A
-
A
V
R
L
G
A
--
K
--
L
I
E
K
H
F
T
I
D
K
N
L
P
G
A
D
H
S
F
A
L
N
P
D
E
L
K
E
-
M
V
D
G
I
R
K
T
E
A
-
E
L
K
Q
G
I
T
K
P
V
S
E
K
L
L
G
S
S
Y
K
T
T
T
A
I
E
G
E
--
I
R
N
F
A
Y
R
G
I
F
T
T
A
P
I
Q
K
G
E
A
F
S
E
D
N
I
A
V
L
R
P
G
Q
K
P
Q
G
-
L
H
P
R
F
F
E
L
L
T
S
-
G
V
R
A
V
R
D
I
P
A
D
T
G
I
-
V
W
D
D
I
L
L
K
D
-----
32
HHSearch
92.48
99%
-75
- C4 -
1VLI
1
SPSE_BACSU
A:
[14-380]
-
A
A
F
Q
I
A
N
K
T
V
G
K
D
A
P
V
F
I
I
A
E
-
A
G
I
N
H
D
-
G
K
L
D
Q
A
F
A
L
I
D
A
A
A
E
A
--
G
A
-----
D
---
A
V
K
F
Q
-
M
F
-----
Q
A
D
-
R
M
Y
Q
K
D
P
---------
D
-
V
S
I
F
S
L
V
Q
S
M
E
-
M
-
P
A
-
E
W
-
I
L
P
L
L
D
-
Y
C
R
E
K
Q
V
I
F
L
S
T
V
C
D
E
G
S
A
D
L
L
Q
S
T
S
P
S
A
F
K
I
A
S
Y
E
I
N
H
L
P
L
L
K
Y
V
A
R
L
N
R
P
-
M
I
F
S
T
A
G
-
A
-
E
I
S
D
V
H
E
A
W
R
T
-
I
R
A
E
G
N
N
Q
I
A
I
M
-
H
-
C
V
--
A
-
K
Y
P
-
A
P
P
E
Y
S
N
L
S
V
I
P
-
M
L
A
A
A
F
P
E
A
V
I
G
F
-
S
D
H
S
-----
E
H
P
T
-----
E
-
A
P
C
-
A
-
A
V
R
L
G
A
--
K
--
L
I
E
K
H
F
T
I
D
K
N
L
P
G
A
D
H
S
F
A
L
N
P
D
E
L
K
E
-
M
V
D
G
I
R
K
T
E
A
-
E
L
K
Q
G
I
T
K
P
V
S
E
K
L
L
G
S
S
Y
K
T
T
T
A
I
E
G
E
--
I
R
N
F
A
Y
R
G
I
F
T
T
A
P
I
Q
K
G
E
A
F
S
E
D
N
I
A
V
L
R
P
G
Q
K
P
Q
G
-
L
H
P
R
F
F
E
L
-
L
T
S
G
V
R
A
V
R
D
I
P
A
D
T
G
I
-
V
W
D
D
I
L
L
K
D
-----
22
Fugue
76.28
86%
24
- C4 -
1VLI
1
SPSE_BACSU
A:
[14-380]
-
A
A
F
Q
I
A
N
K
T
V
G
K
D
A
P
V
F
I
I
A
E
-
A
G
I
N
H
D
-
G
K
L
D
Q
A
F
A
L
I
D
A
A
A
E
A
--
G
A
-----
D
---
A
V
K
F
Q
M
F
Q
-----
A
D
R
M
Y
Q
K
D
P
D
V
S
I
F
S
L
--------------
V
Q
S
M
E
M
P
A
-
E
W
-
I
L
P
L
L
D
-
Y
C
R
E
K
Q
V
I
F
L
S
T
V
C
D
E
G
S
A
D
L
L
Q
S
T
S
P
S
A
F
K
I
A
S
Y
E
I
N
H
L
P
L
L
K
Y
V
A
R
L
N
R
P
M
I
F
-
S
T
A
G
-
A
-
E
I
S
D
V
H
E
A
W
R
T
-
I
R
-
A
E
G
N
N
Q
I
A
I
M
H
-
C
V
--
A
-
K
Y
P
-
A
P
P
E
Y
S
N
L
S
V
I
P
M
L
A
A
A
F
P
-
E
A
V
I
G
F
-
S
D
H
S
-----
E
H
-
P
T
----
E
-
A
P
C
-
A
-
A
V
R
L
G
A
--
K
--
L
I
E
K
H
F
T
I
D
K
N
L
P
G
A
D
H
S
F
A
L
N
P
D
E
L
K
E
M
V
D
G
I
R
K
T
E
A
E
-
L
K
Q
-
G
I
T
K
P
V
S
E
K
L
L
G
S
S
Y
K
T
T
T
A
I
E
G
E
--
I
R
N
F
A
Y
R
G
I
F
T
T
A
P
I
Q
K
G
E
A
F
S
E
D
N
I
A
V
L
R
P
G
Q
K
P
Q
G
-
L
H
P
R
F
F
E
L
L
T
S
-
G
V
R
A
V
R
D
I
P
A
D
T
G
I
-
V
W
D
D
I
L
L
K
D
-----
34
HHSearch
73.65
34%
-104
- C4 -
2WQP
8
?
A:
[4-349]
N
N
E
F
K
I
G
N
R
S
V
G
Y
N
H
E
P
L
I
I
C
E
-
I
G
I
N
H
E
-
G
S
L
K
T
A
F
E
M
V
D
A
A
Y
N
A
--
G
A
-----
E
---
V
V
K
H
Q
-
T
H
-----
I
V
E
-
D
E
M
S
D
E
A
K
Q
V
I
P
G
N
-
A
D
-
V
S
I
Y
E
I
M
E
R
C
A
-
L
-
N
E
-
E
D
-
E
I
K
L
K
E
-
Y
V
E
S
K
G
M
I
F
I
S
T
L
F
S
R
A
A
A
L
R
L
Q
R
M
D
I
P
A
Y
K
I
G
S
G
E
C
N
N
Y
P
L
I
K
L
V
A
S
F
G
K
P
-
I
I
L
S
T
G
M
-
N
-
S
I
E
S
I
K
K
S
V
E
I
-
I
R
E
A
G
-
V
P
Y
A
L
L
-
H
-
C
T
--
N
-
I
Y
P
-
T
P
Y
E
D
V
R
L
G
G
M
N
-
D
L
S
E
A
F
P
D
A
I
I
G
L
-
S
D
H
T
-----
L
D
-
N
-----
Y
-
A
C
L
-
G
-
A
V
A
L
G
G
--
S
--
I
L
E
R
H
F
T
D
R
M
D
R
P
G
P
D
I
V
C
S
M
N
P
D
T
F
K
E
-
L
K
Q
G
A
H
A
L
K
L
-
A
R
G
G
K
-------------
K
D
T
I
I
A
G
E
K
P
--
T
K
D
F
A
F
A
S
V
V
A
D
K
D
I
K
K
G
E
L
L
S
G
D
N
L
W
V
K
R
P
G
--
N
-
G
D
F
S
V
N
E
Y
E
T
-
L
F
-
G
K
V
A
A
C
N
I
R
K
G
A
Q
I
-
K
K
T
D
I
E
--------
6
PsiBlast_PDB
61.92
35%
8
- C4 -
4IPJ
2
?
A:
[9-319]
---
F
K
I
G
N
R
S
V
G
Y
N
H
E
P
L
I
I
C
E
-
I
G
I
N
H
E
-
G
S
L
K
T
A
F
E
M
V
D
A
A
Y
N
A
--
G
A
-----
E
---
V
V
K
H
Q
-
T
H
IVEDE
M
S
D
-
E
A
K
Q
V
I
P
G
------
N
A
D
-
V
S
I
Y
E
I
M
E
R
C
A
-
L
-
N
E
-
E
D
-
E
I
K
L
K
E
-
Y
V
E
S
K
G
M
I
F
I
S
T
P
F
S
R
A
A
A
L
R
L
Q
R
M
D
I
P
A
Y
K
I
G
S
G
E
C
N
N
Y
P
L
I
K
L
V
A
S
F
G
K
P
-
I
I
L
S
T
G
M
-
N
-
S
I
E
S
I
K
K
S
V
E
I
-
I
R
-
E
A
G
V
P
Y
A
L
L
-
H
-
C
T
--
N
-
I
Y
P
-
T
P
Y
E
D
V
R
L
G
G
M
N
-
D
L
S
E
A
F
P
D
A
I
I
G
L
-
S
D
H
T
------
L
-
D
N
----
Y
-
A
C
L
-
G
-
A
V
A
L
G
G
--
S
--
I
L
E
R
H
F
T
D
R
M
D
R
P
G
P
D
I
V
C
S
M
N
P
D
T
F
K
-------------
E
L
K
Q
G
----
A
H
A
L
K
L
A
R
G
G
K
K
D
T
I
I
A
G
E
K
P
T
K
D
F
A
F
A
S
V
V
A
D
K
D
I
K
K
G
E
L
L
S
G
D
N
L
W
V
K
K
P
G
N
----------------------------------------------
2
PsiBlast_PDB
61.91
36%
10
- C4 -
1XUU
2
?
A:
[7-317]
---
F
K
I
G
N
R
S
V
G
Y
N
H
E
P
L
I
I
C
E
-
I
G
I
N
H
E
-
G
S
L
K
T
A
F
E
M
V
D
A
A
Y
N
A
--
G
A
-----
E
---
V
V
K
H
Q
-
T
H
IVEDE
M
S
D
-
E
A
K
Q
V
I
P
G
------
N
A
D
-
V
S
I
Y
E
I
M
E
R
C
A
-
L
-
N
E
-
E
D
-
E
I
K
L
K
E
-
Y
V
E
S
K
G
M
I
F
I
S
T
P
F
S
R
A
A
A
L
R
L
Q
R
M
D
I
P
A
Y
K
I
G
S
G
E
C
N
N
Y
P
L
I
K
L
V
A
S
F
G
K
P
-
I
I
L
S
T
G
M
-
N
-
S
I
E
S
I
K
K
S
V
E
I
-
I
R
-
E
A
G
V
P
Y
A
L
L
-
H
-
C
T
--
N
-
I
Y
P
-
T
P
Y
E
D
V
R
L
G
G
M
N
-
D
L
S
E
A
F
P
D
A
I
I
G
L
-
S
D
H
T
------
L
-
D
N
----
Y
-
A
C
L
-
G
-
A
V
A
L
G
G
--
S
--
I
L
E
R
H
F
T
D
R
M
D
R
P
G
P
D
I
V
C
S
M
N
P
D
T
F
K
-------------
E
L
K
Q
G
----
A
H
A
L
K
L
A
R
G
G
K
K
D
T
I
I
A
G
E
K
P
T
K
D
F
A
F
A
S
V
V
A
D
K
D
I
K
K
G
E
L
L
S
G
D
N
L
W
V
K
R
P
G
N
----------------------------------------------
8
PsiBlast_PDB
61.60
35%
12
- C4 -
4IPI
3
?
A:
[9-319]
---
F
K
I
G
N
R
S
V
G
Y
N
H
E
P
L
I
I
C
E
-
I
G
I
N
H
E
-
G
S
L
K
T
A
F
E
M
V
D
A
A
Y
N
A
--
G
A
-----
E
---
V
V
K
H
Q
-
T
H
IVEDE
M
S
D
-
E
A
K
Q
V
I
P
G
------
N
A
D
-
V
S
I
Y
E
I
M
E
R
C
A
-
L
-
N
E
-
E
D
-
E
I
K
L
K
E
-
Y
V
E
S
K
G
M
I
F
I
S
T
P
F
S
R
A
A
A
L
R
L
Q
R
M
D
I
P
A
Y
K
I
G
S
G
E
C
N
N
Y
P
L
I
K
L
V
A
S
F
G
K
P
-
I
I
L
S
T
G
M
-
N
-
S
I
E
S
I
K
K
S
V
E
I
-
I
R
-
E
A
G
V
P
Y
A
L
L
-
H
-
C
T
--
N
-
I
Y
P
-
T
P
Y
E
D
V
R
L
G
G
M
N
-
D
L
S
E
A
F
P
D
A
I
I
G
L
-
S
D
H
T
------
L
-
D
N
----
Y
-
A
C
L
-
G
-
A
V
A
L
G
G
--
S
--
I
L
E
R
H
F
T
D
R
M
D
R
P
G
P
D
I
V
C
S
M
N
P
D
T
F
K
-------------
E
L
K
Q
G
----
A
H
A
L
K
L
A
R
G
G
K
K
D
T
I
I
A
G
E
K
P
T
K
D
F
A
F
A
S
V
V
A
D
K
D
I
K
K
G
E
L
L
S
G
D
N
L
W
V
K
A
P
G
N
----------------------------------------------
4
PsiBlast_PDB
61.43
36%
13
- C4 -
2ZDR
2
?
A:
[7-317]
---
F
K
I
G
N
R
S
V
G
Y
N
H
E
P
L
I
I
C
E
-
I
G
I
N
H
E
-
G
S
L
K
T
A
F
E
M
V
D
A
A
Y
N
A
--
G
A
-----
E
---
V
V
K
H
Q
-
T
H
IVEDE
M
S
D
-
E
A
K
Q
V
I
P
G
------
N
A
D
-
V
S
I
Y
E
I
M
E
R
C
A
-
L
-
N
E
-
E
D
-
E
I
K
L
K
E
-
Y
V
E
S
K
G
M
I
F
I
S
T
P
F
S
R
A
A
A
L
R
L
Q
R
M
D
I
P
A
Y
K
I
G
S
G
E
C
N
N
Y
P
L
I
K
L
V
A
S
F
G
K
P
-
I
I
L
S
T
G
M
-
N
-
S
I
E
S
I
K
K
S
V
E
I
-
I
R
-
E
A
G
V
P
Y
A
L
L
-
H
-
C
T
--
N
-
I
Y
P
-
T
P
Y
E
D
V
R
L
G
G
M
N
-
D
L
S
E
A
F
P
D
A
I
I
G
L
-
S
D
H
T
------
L
-
D
N
----
Y
-
A
C
L
-
G
-
A
V
A
L
G
G
--
S
--
I
L
E
R
H
F
T
D
R
M
D
R
P
G
P
D
I
V
C
S
M
N
P
D
T
F
K
-------------
E
L
K
Q
G
----
A
H
A
L
K
L
A
R
G
G
K
K
D
T
I
I
A
G
E
K
P
T
K
D
F
A
F
A
S
V
V
A
D
K
D
I
K
K
G
E
L
L
S
G
D
N
L
W
V
K
R
P
G
N
----------------------------------------------
5
PsiBlast_PDB
61.31
36%
13
- C4 -
3CM4
1
?
A:
[7-317]
---
F
K
I
G
N
R
S
V
G
Y
N
H
E
P
L
I
I
C
E
-
I
G
I
N
H
E
-
G
S
L
K
T
A
F
E
M
V
D
A
A
Y
N
A
--
G
A
-----
E
---
V
V
K
H
Q
-
T
H
IVEDE
M
S
D
-
E
A
K
Q
V
I
P
G
------
N
A
D
-
V
S
I
Y
E
I
M
E
R
C
A
-
L
-
N
E
-
E
D
-
E
I
K
L
K
E
-
Y
V
E
S
K
G
M
I
F
I
S
T
P
F
S
R
A
A
A
L
R
L
Q
R
M
D
I
P
A
Y
K
I
G
S
G
E
C
N
N
Y
P
L
I
K
L
V
A
S
F
G
K
P
-
I
I
L
S
T
G
M
-
N
-
S
I
E
S
I
K
K
S
V
E
I
-
I
R
-
E
A
G
V
P
Y
A
L
L
-
H
-
C
T
--
N
-
I
Y
P
-
T
P
Y
E
D
V
R
L
G
G
M
N
-
D
L
S
E
A
F
P
D
A
I
I
G
L
-
S
D
H
T
------
L
-
D
N
----
Y
-
A
C
L
-
G
-
A
V
A
L
G
G
--
S
--
I
L
E
R
H
F
T
D
R
M
D
R
P
G
P
D
I
V
C
S
M
N
P
D
T
F
K
-------------
E
L
K
Q
G
----
A
H
A
L
K
L
A
R
G
G
K
K
D
T
I
I
A
G
E
K
P
T
K
D
F
A
F
A
S
V
V
A
D
K
D
I
K
K
G
E
L
L
S
G
D
N
L
W
V
K
R
P
G
N
----------------------------------------------
7
PsiBlast_PDB
61.26
35%
7
- C4 -
2WQP
8
?
A:
[7-317]
---
F
K
I
G
N
R
S
V
G
Y
N
H
E
P
L
I
I
C
E
-
I
G
I
N
H
E
-
G
S
L
K
T
A
F
E
M
V
D
A
A
Y
N
A
--
G
A
-----
E
---
V
V
K
H
Q
-
T
H
I
V
E
D
E
M
S
D
-
E
A
K
Q
V
I
P
G
------
N
A
D
-
V
S
I
Y
E
I
M
E
R
C
A
-
L
-
N
E
-
E
D
-
E
I
K
L
K
E
-
Y
V
E
S
K
G
M
I
F
I
S
T
L
F
S
R
A
A
A
L
R
L
Q
R
M
D
I
P
A
Y
K
I
G
S
G
E
C
N
N
Y
P
L
I
K
L
V
A
S
F
G
K
P
-
I
I
L
S
T
G
M
-
N
-
S
I
E
S
I
K
K
S
V
E
I
-
I
R
-
E
A
G
V
P
Y
A
L
L
-
H
-
C
T
--
N
-
I
Y
P
-
T
P
Y
E
D
V
R
L
G
G
M
N
-
D
L
S
E
A
F
P
D
A
I
I
G
L
-
S
D
H
T
------
L
-
D
N
----
Y
-
A
C
L
-
G
-
A
V
A
L
G
G
--
S
--
I
L
E
R
H
F
T
D
R
M
D
R
P
G
P
D
I
V
C
S
M
N
P
D
T
F
K
E
-
L
K
Q
G
A
H
A
L
K
----------------
L
A
R
G
G
K
K
D
T
I
I
A
G
E
K
P
T
K
D
F
A
F
A
S
V
V
A
D
K
D
I
K
K
G
E
L
L
S
G
D
N
L
W
V
K
R
P
G
N
----------------------------------------------
3
PsiBlast_PDB
60.98
36%
10
- C4 -
1XUZ
3
?
A:
[7-317]
---
F
K
I
G
N
R
S
V
G
Y
N
H
E
P
L
I
I
C
E
-
I
G
I
N
H
E
-
G
S
L
K
T
A
F
E
M
V
D
A
A
Y
N
A
--
G
A
-----
E
---
V
V
K
H
Q
-
T
H
I
V
E
D
E
M
S
D
-
E
A
K
Q
V
I
P
G
------
N
A
D
-
V
S
I
Y
E
I
M
E
R
C
A
-
L
-
N
E
-
E
D
-
E
I
K
L
K
E
-
Y
V
E
S
K
G
M
I
F
I
S
T
P
F
S
R
A
A
A
L
R
L
Q
R
M
D
I
P
A
Y
K
I
G
S
G
E
C
N
N
Y
P
L
I
K
L
V
A
S
F
G
K
P
-
I
I
L
S
T
G
M
-
N
-
S
I
E
S
I
K
K
S
V
E
I
-
I
R
-
E
A
G
V
P
Y
A
L
L
-
H
-
C
T
--
N
-
I
Y
P
-
T
P
Y
E
D
V
R
L
G
G
M
N
-
D
L
S
E
A
F
P
D
A
I
I
G
L
-
S
D
H
T
------
L
-
D
N
----
Y
-
A
C
L
-
G
-
A
V
A
L
G
G
--
S
--
I
L
E
R
H
F
T
D
R
M
D
R
P
G
P
D
I
V
C
S
M
N
P
D
T
F
K
-------------
E
L
K
Q
G
----
A
H
A
L
K
L
A
R
G
G
K
K
D
T
I
I
A
G
E
K
P
T
K
D
F
A
F
A
S
V
V
A
D
K
D
I
K
K
G
E
L
L
S
G
D
N
L
W
V
K
R
P
G
N
----------------------------------------------
9
PsiBlast_PDB
59.21
27%
-23
- C4 -
3G8R
1
?
A:
[6-304]
---------------
P
L
F
I
F
E
M
-
A
N
-
N
H
M
-
G
N
V
E
H
G
V
A
L
I
R
A
I
R
E
S
---
C
-----
Q
---
G
F
D
F
D
-
F
G
-----
F
K
L
-
Q
Y
R
N
L
D
T
F
I
H
S
S
F
K
G
R
D
D
V
K
Y
V
K
R
F
E
E
T
R
-
L
-
Q
P
-
E
Q
-
M
Q
K
L
V
A
-
E
M
K
A
N
G
F
K
A
I
C
T
P
F
D
E
E
S
V
D
L
I
E
A
H
G
I
E
I
I
K
I
A
S
C
S
F
T
D
W
P
L
L
E
R
I
A
R
S
D
K
P
-
V
V
A
S
T
A
G
-
A
-
R
R
E
D
I
D
K
V
V
S
F
-
M
L
H
R
G
K
D
-
L
T
I
M
-
H
-
C
V
--
A
-
E
Y
P
-
T
P
D
D
H
L
H
L
A
R
I
K
-
T
L
R
Q
Q
Y
A
G
V
R
I
G
Y
-
S
T
H
E
-----
D
P
-
D
L
----
M
-
E
P
I
-
M
L
A
V
A
Q
G
A
--
T
--
V
F
E
K
H
V
G
L
P
T
D
Q
Y
G
I
N
-
N
Y
S
A
N
P
E
Q
V
R
R
-
W
L
A
A
A
A
R
A
L
A
-
M
L
G
D
G
E
D
D
A
V
S
E
--------
T
E
Q
A
S
L
R
S
--
L
R
----
R
G
V
F
A
T
R
P
V
A
A
G
E
A
L
T
A
D
N
V
S
F
A
F
P
------------------------------------------------
33
HHSearch
56.01
27%
19
- C4 -
3G8R
1
?
A:
[5-341]
---------------
K
P
L
F
I
F
E
-
M
A
N
N
H
M
-
G
N
V
E
H
G
V
A
L
I
R
A
I
R
E
S
C
Q
G
F
-----
D
F
D
F
G
F
K
L
Q
-
Y
R
-----
N
L
D
-
T
F
I
H
S
S
F
K
G
R
-----
D
D
-
V
K
Y
V
K
R
F
E
E
T
R
-
L
-
Q
P
-
E
Q
-
M
Q
K
L
V
A
-
E
M
K
A
N
G
F
K
A
I
C
T
P
F
D
E
E
S
V
D
L
I
E
A
H
G
I
E
I
I
K
I
A
S
C
S
F
T
D
W
P
L
L
E
R
I
A
R
S
D
K
P
-
V
V
A
S
T
A
G
-
A
-
R
R
E
D
I
D
K
V
V
S
F
-
M
L
H
R
G
-
K
D
L
T
I
M
-
H
-
C
V
--
A
-
E
Y
P
-
T
P
D
D
H
L
H
L
A
R
I
K
-
T
L
R
Q
Q
Y
A
G
V
R
I
G
Y
-
S
T
H
E
-----
D
P
-
D
L
M---
E
-
P
I
M
-
L
-
A
V
A
Q
G
A
--
T
--
V
F
E
K
H
V
G
L
P
T
D
Q
Y
G
I
N
-
N
Y
S
A
N
P
E
Q
V
R
R
-
W
L
A
A
A
A
R
A
L
A
-
M
L
G
D
G
E
------------
D
D
A
V
S
E
T
E
Q
A
--
S
L
R
S
L
R
R
G
V
F
A
T
R
P
V
A
A
G
E
A
L
T
A
D
N
V
S
F
A
F
P
P
V
-
E
G
Q
-
L
T
A
N
E
W
S
K
-
Y
V
-
R
Y
T
A
K
T
P
I
A
A
D
A
P
V
-
M
A
A
D
L
E
P
V
------
41
HHSearch
52.72
16%
-67
- C4 -
3NVT
2
?
A:
[131-380]
---
V
T
V
K
G
L
P
I
G
N
G
-
E
P
V
F
V
F
---
G
P
C
S
V
-
E
S
Y
E
Q
V
A
A
V
A
E
S
I
K
A
K
--
G
L
-----
K
---
L
I
R
G
G
-
A
F
-----
K
P
R
-
T
S
----------
P
Y
D
---------
F
Q
--
G
-
L
-
G
L
-
E
G
-
L
K
I
L
K
R
-
V
S
D
E
Y
G
L
G
V
I
S
E
I
V
T
P
A
D
I
E
V
A
L
D
Y
-
V
D
V
I
Q
I
G
A
R
N
M
Q
N
F
E
L
L
K
A
A
G
R
V
D
K
P
-
I
L
L
K
R
G
L
S
A
-
T
I
E
E
F
I
G
A
A
E
Y
-
I
M
S
Q
G
N
G
K
I
I
L
C
-
E
R
G
I
--
R
-
T
Y
E
K
A
T
R
N
T
L
D
I
S
A
V
P
-
I
L
K
K
E
T
-
H
L
P
V
M
V
D
V
T
H
S
-----
T
G
-
R
K
DL
L
L
P
-
C
A
K
-
A
-
A
L
A
I
E
A
--
D
--
G
V
M
A
E
V
H
P
D
P
A
V
A
L
S
D
S
A
Q
Q
M
D
I
P
E
F
E
E
-
F
W
N
A
I
L
A
S
N
L
-
V
------------------------------------------------------------------------------------------------------------
39
HHSearch
51.82
19%
-55
- C4 -
1VS1
2
?
A:
[26-275]
--
V
V
E
V
E
G
V
R
I
G
G
G
-
S
K
A
V
I
A
---
G
P
C
S
V
-
E
S
W
E
Q
V
R
E
A
A
L
A
V
K
E
A
--
G
A
-----
H
---
M
L
R
G
G
-
A
F
-----
K
P
R
-
T
S
----------
P
--------
Y
S
-
F
Q
--
G
-
L
-
G
L
-
E
G
-
L
K
L
L
R
R
-
A
G
D
E
A
G
L
P
V
V
T
E
V
L
D
P
R
H
V
E
T
V
S
R
Y
-
A
D
M
L
Q
I
G
A
R
N
M
Q
N
F
P
L
L
R
E
V
G
R
S
G
K
P
-
V
L
L
K
R
G
F
G
N
-
T
V
E
E
L
L
A
A
A
E
Y
-
I
L
L
E
G
N
W
Q
V
V
L
V
-
E
-
R
G
I
R
T
-
F
E
P
-
S
T
R
F
T
L
D
V
A
A
V
A
-
V
L
K
E
A
T
-
H
L
P
V
I
V
D
P
S
H
P
-----
A
G
-
R
R
SL
V
P
A
-
L
A
K
-
A
-
G
L
A
A
G
A
D
G
L
--
I
V
E
V
H
P
N
P
E
E
A
L
--
S
D
A
K
Q
Q
L
T
P
G
E
F
A
R
-
L
M
G
E
L
R
W
H
R
L
--------------------------------------------------------------------------------------------------------------
23
Fugue
48.87
25%
27
- C4 -
3G8R
1
?
A:
[5-341]
---------------
K
P
L
F
I
F
E
M
A
--
N
N
H
M
G
N
V
E
H
G
V
A
L
I
R
A
I
R
E
S
--
C
Q
GFD
F
D
F
---
G
F
K
L
Q
-
Y
R
-----
N
L
D
-
T
F
I
H
S
S
F
K
G
R
D
D
V
K
Y
------
V
K
R
F
E
E
T
R
-
L
-
Q
P
-
E
Q
M
Q
K
L
V
A
E
M
K
A
N
G
--
F
K
A
I
C
T
P
F
D
E
E
S
V
D
L
I
E
A
H
G
I
E
I
I
K
I
A
S
C
S
F
T
D
W
P
L
L
E
R
I
A
R
S
D
K
P
-
V
V
A
S
T
A
G
-
A
-
R
R
E
D
I
D
K
V
V
S
F
M
L
H
---
R
G
K
D
L
T
I
M
H
-
C
V
--
A
-
E
Y
P
-
T
P
D
D
H
L
H
L
A
R
I
K
-
T
L
R
Q
Q
Y
A
G
V
R
I
G
Y
-
S
T
H
E
------
D
-
P
D
----
L
M
E
P
I
M
L
-
A
V
A
Q
G
A
--
T
--
V
F
E
K
H
V
G
L
P
T
D
Q
Y
G
I
N
N
Y
-
S
A
N
P
E
Q
V
R
R
-
W
L
A
A
A
A
R
A
L
A
M
L
G
-------------
D
G
E
D
D
A
V
S
E
T
E
Q
A
--
S
L
R
S
L
R
R
G
V
F
A
T
R
P
V
A
A
G
E
A
L
T
A
D
N
V
S
F
A
F
P
P
-
V
E
G
Q
-
L
T
A
N
E
W
S
K
Y
V
--
R
Y
T
A
K
T
P
I
A
A
D
A
P
V
M
A
A
D
L
E
P
V
-------
36
HHSearch
47.73
18%
-57
- C4 -
4C1L
4
?
A:
[12-260]
--
V
V
K
I
N
D
V
K
F
G
E
--
G
F
T
I
I
A
G
-
P
C
S
I
E
---
S
R
D
Q
I
M
K
V
A
E
F
L
A
E
V
--
G
I
-----
K
---
V
L
R
G
G
-
A
F
-----
K
P
R
-
T
S
----------
P
Y
---------
S
F
Q
--
G
-
Y
-
G
E
-
K
A
-
L
R
W
M
R
E
-
A
A
D
E
Y
G
L
V
T
V
T
E
V
M
D
T
R
H
V
E
L
V
A
K
Y
-
S
D
I
L
Q
I
G
A
R
N
S
Q
N
F
E
L
L
K
E
V
G
K
V
E
N
P
-
V
L
L
K
R
G
M
G
N
-
T
I
Q
E
L
L
Y
S
A
E
Y
-
I
M
A
Q
G
N
E
N
V
I
L
C
-
E
-
R
G
--
I
R
T
F
E
T
A
T
R
F
T
L
D
D
S
A
V
P
-
V
V
K
E
L
S
-
H
L
P
I
I
V
D
P
S
H
P
-----
A
G
-
R
R
SL
V
I
P
-
L
A
K
-
A
-
A
Y
A
I
G
A
D
G
I
--
M
V
E
V
H
P
E
P
E
K
A
L
--
S
D
S
Q
Q
Q
L
T
F
D
D
F
L
Q
-
L
L
K
E
L
E
A
L
G
W
--------------------------------------------------------------------------------------------------------------
48
HHSearch
47.68
15%
-153
- C- -
1MSI
-
ANP12_ZOAAM
A:
[1-62]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
A
S
V
V
A
N
Q
L
I
P
I
N
T
A
L
T
L
V
M
M
R
S
E
V
V
T
--
P
V
G
-
I
P
A
E
D
I
P
R
-
L
V
-
S
M
Q
V
N
R
A
V
P
L
G
T
T
L
-
M
P
D
M
V
K
G
-------
47
HHSearch
46.98
15%
-157
- C- -
1UCS
-
ANP1_LYCDA
A:
[2-62]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
S
V
V
A
N
Q
L
I
P
I
N
T
A
L
T
L
I
M
M
K
A
E
V
V
T
--
P
M
G
-
I
P
A
E
E
I
P
K
-
L
V
-
G
M
Q
V
N
R
A
V
P
L
G
T
T
L
-
M
P
D
M
V
K
N
-------
42
HHSearch
45.95
17%
-33
- C4 -
3FS2
3
KDSA_BRUME
A:
[28-297]
--
T
V
K
V
G
N
V
T
F
S
N
S
A
P
L
A
L
I
A
---
G
P
C
Q
M
-
E
T
R
D
H
A
F
E
M
A
G
R
L
K
E
M
--
T
D
-----
K
---
L
G
I
G
L
-
V
Y
-----
K
S
S
-
F
D
K
A
----
N
---------------------
I
-
G
L
E
K
A
-
L
E
V
F
S
D
-
L
K
K
E
Y
G
F
P
V
L
T
D
I
H
T
E
E
Q
C
A
A
V
A
P
V
-
V
D
V
L
Q
I
P
A
F
L
C
R
Q
T
D
L
L
I
A
A
A
R
T
G
R
V
-
V
N
V
K
K
G
Q
-
F
L
A
P
W
D
M
K
N
V
L
A
K
-
I
T
E
S
G
N
P
N
V
L
A
T
-
E
-
R
G
--
V
-
S
F
G
-
Y
N
T
L
V
S
D
M
R
A
L
P
-
I
M
A
G
L
--
G
A
P
V
I
F
D
A
T
H
S
VQQPG---
Q
R
EF
V
E
T
-
L
A
R
-
A
-
A
V
A
V
G
V
--
A
G
F
F
I
E
T
H
E
D
P
D
N
A
P
--
S
D
G
P
N
M
V
P
I
D
K
M
P
A
-
L
L
E
K
L
M
A
F
D
R
-
I
A
K
A
---------------------------------------------------------------------------------------------------------