@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu37890: (2016-08-03 )
MVQKRNHFLPYSLPLIGKEEIQEVTETLESGWLSKGPKVQQFEKEFAAFVGAKHAVAVNSCTAALFLALKAKGIGPGDEVITSPLTFSSTANTIIHTGATPVFADIDENTLNIDPVKLEAAVTPRTKAVVPVHFGGQSCDMDAILAVAQNHGLFVLEDAAHAVYTTYKQRMIGSIGDATAFSFYATKNLATGEGGMLTTDDEELADKIRVLSLHGMSKAAWNRYSSNGSWYYEVESPGYKMNMFDLQAALGLHQLKRLDDMQKRREEIAGRYQTAFQQIPGLITPFVHDDGRHAWHLYVLQVDEKKAGVTRSEMITALKDEYNIGTSVHFIPVHIHPYYQKQFGYKEADFPNAMNYYKRTLSLPLYPSMSDDDVDDVIEAVRDIVKGAD
Atome Classification :
(33 SA)
.........10........20--.-...----.....30--.-...-.-...40........50........60........70-...--......80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190-........200.......210.......220.......230.......240.......250.......260.......270--.......280--..--.-.-....--.290...--....300........310.......320........330.-..-.---....340.......350.......360.......370.......380.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MVQKRNHFLPYSLPLI
G
K
E
E
---
I
-
Q
E
V
----
T
E
T
L
E
S
G
--W-LSK-G-P
K
V
Q
Q
F
E
K
E
F
A
A
F
VGAK
H
A
V
A
V
N
S
C
T
A
A
L
F
L
A
L
K
--AKG--IGPGDE
V
I
TSPLTFSSTA
N
T
I
I
HTGAT
P
V
F
A
DIDENTLNID
P
V
K
L
E
A
AVTPR
T
K
A
V
V
P
V
HFGGQSC
D
M
D
A
I
L
A
V
AQNH
G
L
F
V
LEDA
A
H
A
V
Y
T
T
Y
K
Q
R
M
I
GSIGDA
T
A
F
S
F
Y
A
TKNLA-T-GEGG
M
L
TT
D
D
E
E
L
A
D
K
I
R
V
L
S
LHGM
S
K
A
A
WNRYSSNG
S
W
Y
Y
E
VESPG
Y
K
M
N
M
F
D
L
Q
A
A
L
G
L
H
Q
L
K
R
L
D
D
M
Q
K
R
R
E
E
I
A
G
R
Y
--
Q
T
A
F
Q
QIP----
G
L
--
I
-
T
-
P
FVH--DDG
R
H
A
W
--
H
L
Y
V
L
-
Q
VDEKKAGV
T
R
S
E
M
I
T
A
L
K
D-EYNIG
T
S
V
H
F
-
I
P
-
V
H-I---H
P
Y
Y
Q
K
QFGYKEADFP
N
A
M
N
Y
Y
K
R
T
LSLPLYPSMSDD
D
V
D
D
V
I
E
A
V
R
D
I
VKGAD
3
PsiBlast_PDB
97.30
44%
-110
- C1 -
4OCA
1
?
A:
[10-382]
-------
F
L
P
F
S
R
P
A
M
G
A
E
E
---
L
-
A
A
V
----
K
T
V
L
D
S
G
--
W
-
I
T
T
-
G
-
P
K
N
Q
E
L
E
A
A
F
C
R
L
T
G
N
Q
Y
A
V
A
V
S
S
A
T
A
G
M
H
I
A
L
M
--
A
L
G
--
I
G
E
G
D
E
V
I
T
P
S
M
T
W
V
S
T
L
N
M
I
V
L
L
G
A
N
P
V
M
V
D
V
D
R
D
T
L
M
V
T
P
E
H
I
E
A
A
I
T
P
Q
T
K
A
I
I
P
V
H
Y
A
G
A
P
A
D
L
D
A
I
Y
A
L
G
E
R
Y
G
I
P
V
I
E
D
A
A
H
A
T
G
T
S
Y
K
G
R
H
I
G
A
R
G
T
A
I
-
F
S
F
H
A
I
A
N
I
T
-
C
-
A
E
G
G
I
V
V
T
D
N
P
Q
F
A
D
K
L
R
S
L
K
F
H
G
L
G
--------------
A
E
V
L
A
P
G
Y
K
Y
N
L
P
D
L
N
A
A
I
A
L
A
Q
L
Q
K
L
D
A
L
N
A
R
R
A
A
I
A
A
Q
Y
--
H
Q
A
M
A
D
L
P
----
F
Q
--
P
-
L
-
S
L
P
S
--
W
E
H
I
H
A
W
--
H
L
F
I
I
-
R
V
D
E
A
R
C
G
I
T
R
D
A
L
M
A
S
L
K
T
-
K
-
G
I
G
T
G
L
H
F
-
R
A
-
A
H
-
T
---
Q
K
Y
Y
R
E
R
F
--
P
T
L
T
L
P
D
T
E
W
N
S
E
R
I
C
S
L
P
L
F
P
D
M
T
E
S
D
F
D
R
V
I
T
A
L
H
Q
I
-----
4
PsiBlast_PDB
96.47
44%
-107
- C1 -
1MDO
1
ARNB_SALTY
A:
[10-382]
-------
F
L
P
F
S
R
P
A
M
G
A
E
E
---
L
-
A
A
V
----
K
T
V
L
D
S
G
--
W
-
I
T
T
-
G
-
P
K
N
Q
E
L
E
A
A
F
C
R
L
T
G
N
Q
Y
A
V
A
V
S
S
A
T
A
G
M
H
I
A
L
M
--
A
L
G
--
I
G
E
G
D
E
V
I
T
P
S
M
T
W
V
S
T
L
N
M
I
V
L
L
G
A
N
P
V
M
V
D
V
D
R
D
T
L
M
V
T
P
E
H
I
E
A
A
I
T
P
Q
T
K
A
I
I
P
V
H
Y
A
G
A
P
A
D
L
D
A
I
Y
A
L
G
E
R
Y
G
I
P
V
I
E
D
A
A
H
A
T
G
T
S
Y
K
G
R
H
I
G
A
R
G
T
A
I
-
F
S
F
H
A
I
K
N
I
T
-
C
-
A
E
G
G
I
V
V
T
D
N
P
Q
F
A
D
K
L
R
S
L
K
F
H
G
L
G
V
D
-----------
Q
A
E
V
L
A
P
G
Y
K
Y
N
L
P
D
L
N
A
A
I
A
L
A
Q
L
Q
K
L
D
A
L
N
A
R
R
A
A
I
A
A
Q
Y
--
H
Q
A
M
A
D
L
P
----
F
Q
--
P
-
L
-
S
L
P
S
--
W
E
H
I
H
A
W
--
H
L
F
I
I
-
R
V
D
E
A
R
C
G
I
T
R
D
A
L
M
A
S
L
K
T
-
K
-
G
I
G
T
G
L
H
F
-
R
A
-
A
H
-
T
---
Q
K
Y
Y
R
E
R
F
--
P
T
L
T
L
P
D
T
E
W
N
S
E
R
I
C
S
L
P
L
F
P
D
M
T
E
S
D
F
D
R
V
I
T
A
L
H
Q
I
-----
63
HHSearch
95.85
43%
-106
- C1 -
1MDO
1
ARNB_SALTY
A:
[9-384]
------
D
F
L
P
F
S
R
P
A
M
G
A
E
E
---
L
-
A
A
V
----
K
T
V
L
D
S
G
--
W
-
I
T
T
-
G
-
P
K
N
Q
E
L
E
A
A
F
C
R
L
T
G
N
Q
Y
A
V
A
V
S
S
A
T
A
G
M
H
I
A
L
M
--
A
L
G
--
I
G
E
G
D
E
V
I
T
P
S
M
T
W
V
S
T
L
N
M
I
V
L
L
G
A
N
P
V
M
V
D
V
D
R
D
T
L
M
V
T
P
E
H
I
E
A
A
I
T
P
Q
T
K
A
I
I
P
V
H
Y
A
G
A
P
A
D
L
D
A
I
Y
A
L
G
E
R
Y
G
I
P
V
I
E
D
A
A
H
A
T
G
T
S
Y
K
G
R
H
I
G
A
-
R
G
T
A
I
F
S
F
H
A
I
K
N
I
T
-
C
-
A
E
G
G
I
V
V
T
D
N
P
Q
F
A
D
K
L
R
S
L
K
F
H
G
L
G
V
D
-----------
Q
A
E
V
L
A
P
G
Y
K
Y
N
L
P
D
L
N
A
A
I
A
L
A
Q
L
Q
K
L
D
A
L
N
A
R
R
A
A
I
A
A
Q
Y
--
H
Q
A
M
A
D
L
P
----
F
Q
--
P
-
L
-
S
L
P
S
--
W
E
H
I
H
A
W
--
H
L
F
I
I
-
R
V
D
E
A
R
C
G
I
T
R
D
A
L
M
A
S
L
K
T
-
K
-
G
I
G
T
G
L
H
F
-
R
A
-
A
H
-
T
---
Q
K
Y
Y
R
E
R
--
F
P
T
L
T
L
P
D
T
E
W
N
S
E
R
I
C
S
L
P
L
F
P
D
M
T
E
S
D
F
D
R
V
I
T
A
L
H
Q
I
A
G
---
2
PsiBlast_PDB
95.39
44%
-110
- C1 -
1MDZ
1
ARNB_SALTY
A:
[10-382]
-------
F
L
P
F
S
R
P
A
M
G
A
E
E
---
L
-
A
A
V
----
K
T
V
L
D
S
G
--
W
-
I
T
T
-
G
-
P
K
N
Q
E
L
E
A
A
F
C
R
L
T
G
N
Q
Y
A
V
A
V
S
S
A
T
A
G
M
H
I
A
L
M
--
A
L
G
--
I
G
E
G
D
E
V
I
T
P
S
M
T
W
V
S
T
L
N
M
I
V
L
L
G
A
N
P
V
M
V
D
V
D
R
D
T
L
M
V
T
P
E
H
I
E
A
A
I
T
P
Q
T
K
A
I
I
P
V
H
Y
A
G
A
P
A
D
L
D
A
I
Y
A
L
G
E
R
Y
G
I
P
V
I
E
D
A
A
H
A
T
G
T
S
Y
K
G
R
H
I
G
A
R
G
T
A
I
-
F
S
F
H
A
I
K
N
I
T
-
C
-
A
E
G
G
I
V
V
T
D
N
P
Q
F
A
D
K
L
R
S
L
K
F
H
G
L
G
V
D
-----------
Q
A
E
V
L
A
P
G
Y
K
Y
N
L
P
D
L
N
A
A
I
A
L
A
Q
L
Q
K
L
D
A
L
N
A
R
R
A
A
I
A
A
Q
Y
--
H
Q
A
M
A
D
L
P
----
F
Q
--
P
-
L
-
S
L
P
S
--
W
E
H
I
H
A
W
--
H
L
F
I
I
-
R
V
D
E
A
R
C
G
I
T
R
D
A
L
M
A
S
L
K
T
-
K
-
G
I
G
T
G
L
H
F
-
R
A
-
A
H
-
T
---
Q
K
Y
Y
R
E
R
F
--
P
T
L
T
L
P
D
T
E
W
N
S
E
R
I
C
S
L
P
L
F
P
D
M
T
E
S
D
F
D
R
V
I
T
A
L
H
Q
I
-----
1
PsiBlast_PDB
93.54
44%
-109
- C1 -
1MDX
4
ARNB_SALTY
A:
[10-382]
-------
F
L
P
F
S
R
P
A
M
G
A
E
E
---
L
-
A
A
V
----
K
T
V
L
D
S
G
--
W
-
I
T
T
-
G
-
P
K
N
Q
E
L
E
A
A
F
C
R
L
T
G
N
Q
Y
A
V
A
V
S
S
A
T
A
G
M
H
I
A
L
M
--
A
L
G
--
I
G
E
G
D
E
V
I
T
P
S
M
T
W
V
S
T
L
N
M
I
V
L
L
G
A
N
P
V
M
V
D
V
D
R
D
T
L
M
V
T
P
E
H
I
E
A
A
I
T
P
Q
T
K
A
I
I
P
V
H
Y
A
G
A
P
A
D
L
D
A
I
Y
A
L
G
E
R
Y
G
I
P
V
I
E
D
A
A
H
A
T
G
T
S
Y
K
G
R
H
I
G
A
R
G
T
A
I
-
F
S
F
H
A
I
K
N
I
T
-
C
-
A
E
G
G
I
V
V
T
D
N
P
Q
F
A
D
K
L
R
S
L
K
F
H
G
L
----------
G
R
A
P
Q
A
E
V
L
A
P
G
Y
K
Y
N
L
P
D
L
N
A
A
I
A
L
A
Q
L
Q
K
L
D
A
L
N
A
R
R
A
A
I
A
A
Q
Y
--
H
Q
A
M
A
D
L
P
----
F
Q
--
P
-
L
-
S
L
P
S
--
W
E
H
I
H
A
W
--
H
L
F
I
I
-
R
V
D
E
A
R
C
G
I
T
R
D
A
L
M
A
S
L
K
T
-
K
-
G
I
G
T
G
L
H
F
-
R
A
-
A
H
-
T
---
Q
K
Y
Y
R
E
R
F
--
P
T
L
T
L
P
D
T
E
W
N
S
E
R
I
C
S
L
P
L
F
P
D
M
T
E
S
D
F
D
R
V
I
T
A
L
H
Q
I
-----
60
HHSearch
89.76
40%
-78
- C1 -
4LC3
10
?
A:
[14-389]
-----
A
P
F
L
P
F
T
R
P
E
I
D
E
E
T
---
I
-
Q
G
V
----
V
E
V
L
R
S
G
--
W
-
I
T
T
-
G
-
P
Q
C
Q
K
F
E
A
A
L
S
E
Y
C
G
G
R
P
V
R
V
F
N
S
G
T
C
T
L
E
I
G
L
R
--
I
A
G
--
V
G
P
G
D
E
V
I
T
T
P
A
S
W
V
S
T
S
N
V
I
I
E
T
G
A
T
P
V
F
A
D
I
D
P
V
T
R
N
I
D
L
D
K
L
E
Q
A
I
T
P
R
T
K
A
I
I
P
V
F
L
S
G
L
P
V
D
M
D
R
L
Y
A
I
A
R
A
H
K
L
R
V
I
E
D
A
A
Q
A
F
G
S
T
W
H
G
K
R
I
G
A
I
G
D
L
V
S
F
S
F
H
A
N
K
N
L
T
-
T
-
I
E
G
G
A
L
V
L
N
N
E
D
E
A
V
L
A
Q
K
Y
R
L
Q
G
I
T
R
T
G
F
D
--------
G
M
D
C
D
V
L
G
G
K
Y
N
L
T
D
V
A
A
R
V
G
L
G
Q
L
P
H
L
E
R
F
T
A
Q
R
R
A
L
A
R
A
Y
--
F
A
A
F
D
G
G
A
A
A
K
L
G
V
--
G
-
L
-
P
V
A
E
---
F
E
N
G
N
W
--
H
M
F
L
V
-
T
L
P
L
E
R
L
T
I
T
R
A
E
F
M
A
Q
M
K
E
-
R
-
G
I
G
T
G
I
H
Y
-
P
A
-
I
H
-
L
---
F
T
L
Y
R
A
R
-
G
F
K
E
G
M
F
P
H
A
E
R
Y
G
A
S
T
V
T
L
P
L
F
T
Q
M
T
E
G
D
V
R
R
V
V
D
A
V
N
Q
I
C
E
Q
Y
-
21
PsiBlast_CBE
89.19
39%
-79
- C1 -
4LC3
10
?
B:
[14-387]
-----
A
P
F
L
P
F
T
R
P
E
I
D
E
E
T
---
I
-
Q
G
V
----
V
E
V
L
R
S
G
--
W
-
I
T
T
-
G
-
P
Q
C
Q
K
F
E
A
A
L
S
E
Y
C
G
G
R
P
V
R
V
F
N
S
G
T
C
T
L
E
I
G
L
R
--
I
A
G
--
V
G
P
G
D
E
V
I
T
T
P
A
S
W
V
S
T
S
N
V
I
I
E
T
G
A
T
P
V
F
A
D
I
D
P
V
T
R
N
I
D
L
D
K
L
E
Q
A
I
T
P
R
T
K
A
I
I
P
V
F
L
S
G
L
P
V
D
M
D
R
L
Y
A
I
A
R
A
H
K
L
R
V
I
E
D
A
A
Q
A
F
G
S
T
W
H
G
K
R
I
G
A
I
G
D
L
V
S
F
S
F
H
A
N
K
N
L
T
-
T
-
I
E
G
G
A
L
V
L
N
N
E
D
E
A
V
L
A
Q
K
Y
R
L
Q
G
I
T
R
T
G
F
D
G
--------
M
D
C
D
V
L
G
G
K
Y
N
L
T
D
V
A
A
R
V
G
L
G
Q
L
P
H
L
E
R
F
T
A
Q
R
R
A
L
A
R
A
Y
--
F
A
A
F
D
G
G
A
AAKL
G
V
--
G
-
L
-
P
V
A
E
--
F
E
N
G
N
-
W
--
H
M
F
L
V
-
T
L
P
L
E
R
L
T
I
T
R
A
E
F
M
A
Q
M
K
--
E
R
G
I
G
T
G
I
H
Y
-
P
A
-
I
H
-
L
---
F
T
L
Y
R
A
R
-
G
F
K
E
G
M
F
P
H
A
E
R
Y
G
A
S
T
V
T
L
P
L
F
T
Q
M
T
E
G
D
V
R
R
V
V
D
A
V
N
Q
I
C
E
---
5
PsiBlast_PDB
87.39
39%
-79
- C1 -
4LC3
10
?
A:
[14-387]
-----
A
P
F
L
P
F
T
R
P
E
I
D
E
E
T
---
I
-
Q
G
V
----
V
E
V
L
R
S
G
--
W
-
I
T
T
-
G
-
P
Q
C
Q
K
F
E
A
A
L
S
E
Y
C
G
G
R
P
V
R
V
F
N
S
G
T
C
T
L
E
I
G
L
R
--
I
A
G
--
V
G
P
G
D
E
V
I
T
T
P
A
S
W
V
S
T
S
N
V
I
I
E
T
G
A
T
P
V
F
A
D
I
D
P
V
T
R
N
I
D
L
D
K
L
E
Q
A
I
T
P
R
T
K
A
I
I
P
V
F
L
S
G
L
P
V
D
M
D
R
L
Y
A
I
A
R
A
H
K
L
R
V
I
E
D
A
A
Q
A
F
G
S
T
W
H
G
K
R
I
G
A
I
G
D
L
V
S
F
S
F
H
A
N
K
N
L
T
-
T
-
I
E
G
G
A
L
V
L
N
N
E
D
E
A
V
L
A
Q
K
Y
R
L
Q
G
I
T
R
T
G
F
D
G
--------
M
D
C
D
V
L
G
G
K
Y
N
L
T
D
V
A
A
R
V
G
L
G
Q
L
P
H
L
E
R
F
T
A
Q
R
R
A
L
A
R
A
Y
--
F
A
A
F
D
G
G
A
A
A
K
L
G
V
--
G
-
L
-
P
V
A
E
--
F
E
N
G
N
-
W
--
H
M
F
L
V
-
T
L
P
L
E
R
L
T
I
T
R
A
E
F
M
A
Q
M
K
--
E
R
G
I
G
T
G
I
H
Y
-
P
A
-
I
H
-
L
---
F
T
L
Y
R
A
R
-
G
F
K
E
G
M
F
P
H
A
E
R
Y
G
A
S
T
V
T
L
P
L
F
T
Q
M
T
E
G
D
V
R
R
V
V
D
A
V
N
Q
I
C
E
---
27
PsiBlast_CBE
81.71
36%
-51
- C1 -
2OGA
6
DESV_STRVZ
B:
[50-396]
---------------------------
I
----
A
R
V
L
D
S
G
--
R
-
Y
L
L
-
G
-
P
E
L
E
G
F
E
A
E
F
A
A
Y
C
E
T
D
H
A
V
G
V
N
S
G
M
D
A
L
Q
L
A
L
R
--
G
L
G
--
I
G
P
G
D
E
V
I
V
P
S
H
T
Y
I
A
S
W
L
A
V
S
A
T
G
A
T
P
V
P
V
E
P
H
E
D
H
P
T
L
D
P
L
L
V
E
K
A
I
T
P
R
T
R
A
L
L
P
V
H
L
Y
G
H
P
A
D
M
D
A
L
R
E
L
A
D
R
H
G
L
H
I
V
E
D
A
A
Q
A
H
G
A
R
Y
R
G
R
R
I
G
A
G
S
S
V
A
A
F
S
F
Y
P
G
K
N
L
G
-
C
F
G
D
G
G
A
V
V
T
G
D
P
E
L
A
E
R
L
R
M
L
R
N
Y
G
S
R
Q
K
------------
Y
S
H
E
T
K
G
T
N
S
R
L
D
E
M
Q
A
A
V
L
R
I
R
L
A
H
L
D
S
W
N
G
R
R
S
A
L
A
A
E
Y
--
L
S
G
L
A
G
L
P
----
G
I
--
G
-
L
-
P
V
T
A
--
P
D
T
D
P
V
W
--
H
L
F
T
V
-
R
T
E
R
------
R
D
E
L
R
S
H
L
-
D
-
A
R
G
I
D
T
L
T
H
Y
P
V
P
-
V
H
-
L
---
S
P
A
Y
A
G
E
-
A
P
P
E
G
S
L
P
R
A
E
S
F
A
R
Q
V
L
S
L
P
I
G
P
H
L
E
R
P
Q
A
L
R
V
I
D
A
V
R
E
W
A
E
R
V
-
8
PsiBlast_PDB
81.71
36%
0
- C- -
2OGE
10
DESV_STRVZ
A:
[50-395]
---------------------------
I
----
A
R
V
L
D
S
G
--
R
-
Y
L
L
-
G
-
P
E
L
E
G
F
E
A
E
F
A
A
Y
C
E
T
D
H
A
V
G
V
N
S
G
M
D
A
L
Q
L
A
L
R
--
G
L
G
--
I
G
P
G
D
E
V
I
V
P
S
H
T
Y
I
A
S
W
L
A
V
S
A
T
G
A
T
P
V
P
V
E
P
H
E
D
H
P
T
L
D
P
L
L
V
E
K
A
I
T
P
R
T
R
A
L
L
P
V
H
L
Y
G
H
P
A
D
M
D
A
L
R
E
L
A
D
R
H
G
L
H
I
V
E
D
A
A
Q
A
H
G
A
R
Y
R
G
R
R
I
G
A
G
S
S
V
A
A
F
S
F
Y
P
G
K
N
L
G
-
C
F
G
D
G
G
A
V
V
T
G
D
P
E
L
A
E
R
L
R
M
L
R
N
Y
G
S
R
Q
K
------------
Y
S
H
E
T
K
G
T
N
S
R
L
D
E
M
Q
A
A
V
L
R
I
R
L
A
H
L
D
S
W
N
G
R
R
S
A
L
A
A
E
Y
--
L
S
G
L
A
G
L
P
----
G
I
--
G
-
L
-
P
V
T
A
--
P
D
T
D
P
V
W
--
H
L
F
T
V
-
R
T
E
R
------
R
D
E
L
R
S
H
L
-
D
-
A
R
G
I
D
T
L
T
H
Y
P
V
P
-
V
H
-
L
---
S
P
A
Y
A
G
E
-
A
P
P
E
G
S
L
P
R
A
E
S
F
A
R
Q
V
L
S
L
P
I
G
P
H
L
E
R
P
Q
A
L
R
V
I
D
A
V
R
E
W
A
E
R
--
64
HHSearch
81.42
41%
-34
- C1 -
3DR4
2
GDPPS_CAUCR
A:
[28-390]
---------
S
V
A
A
P
R
L
D
G
N
E
---
R
-
D
Y
V
----
L
E
C
M
D
T
T
--
W
I
S
S
V
-
G
-
R
F
I
V
E
F
E
K
A
F
A
D
Y
C
G
V
K
H
A
I
A
C
N
N
G
T
T
A
L
H
L
A
L
V
--
A
M
G
--
I
G
P
G
D
E
V
I
V
P
S
L
T
Y
I
A
S
A
N
S
V
T
Y
C
G
A
T
P
V
L
V
D
N
D
P
R
T
F
N
L
D
A
A
K
L
E
A
L
I
T
P
R
T
K
A
I
M
P
V
H
L
Y
G
Q
I
C
D
M
D
P
I
L
E
V
A
R
R
H
N
L
L
V
I
E
D
A
A
E
A
V
G
A
T
Y
R
G
K
K
S
G
S
L
G
D
C
A
T
F
S
F
F
G
N
A
I
I
T
-
T
-
G
E
G
G
M
I
T
T
N
D
D
D
L
A
A
K
M
R
L
L
R
G
Q
G
M
D
P
N
R
----------
R
Y
W
F
P
I
V
G
F
N
Y
R
M
T
N
I
Q
A
A
I
G
L
A
Q
L
E
R
V
D
E
H
L
A
A
R
E
R
V
V
G
W
Y
--
E
Q
K
L
A
R
L
-----
G
N
--
R
-
V
-
T
K
P
H
V
A
L
T
G
R
H
V
F
--
W
M
Y
T
V
-
R
L
G
E
G
-
L
S
T
T
R
D
Q
V
I
K
D
L
D
A
-
L
-
G
I
E
S
R
P
V
F
-
H
P
-
M
H
-
I
---
M
P
P
Y
A
---
H
L
A
T
D
D
L
K
I
A
E
A
C
G
V
D
G
L
N
L
P
T
H
A
G
L
T
E
A
D
I
D
R
V
I
A
A
L
D
Q
V
L
----
61
HHSearch
80.30
38%
-49
- C1 -
2OGA
7
DESV_STRVZ
A:
[48-396]
-------------------------
A
A
I
----
A
R
V
L
D
S
G
--
R
-
Y
L
L
-
G
-
P
E
L
E
G
F
E
A
E
F
A
A
Y
C
E
T
D
H
A
V
G
V
N
S
G
M
D
A
L
Q
L
A
L
R
--
G
L
G
--
I
G
P
G
D
E
V
I
V
P
S
H
T
Y
I
A
S
W
L
A
V
S
A
T
G
A
T
P
V
P
V
E
P
H
E
D
H
P
T
L
D
P
L
L
V
E
K
A
I
T
P
R
T
R
A
L
L
P
V
H
L
Y
G
H
P
A
D
M
D
A
L
R
E
L
A
D
R
H
G
L
H
I
V
E
D
A
A
Q
A
H
G
A
R
Y
R
G
R
R
I
G
A
G
S
S
V
A
A
F
S
F
Y
P
G
K
N
L
G
C
F
-
G
D
G
G
A
V
V
T
G
D
P
E
L
A
E
R
L
R
M
L
R
N
Y
G
S
R
Q
------------
K
Y
S
H
E
T
K
G
T
N
S
R
L
D
E
M
Q
A
A
V
L
R
I
R
L
A
H
L
D
S
W
N
G
R
R
S
A
L
A
A
E
Y
--
L
S
G
L
A
G
L
P
----
G
I
--
G
-
L
-
P
V
T
A
--
P
D
T
D
P
V
W
--
H
L
F
T
V
-
R
--
T
----
E
R
R
D
E
L
R
S
H
L
D
A
-
R
-
G
I
D
T
L
T
H
Y
P
V
P
-
V
H
-
L
---
S
P
A
Y
A
G
E
-
A
P
P
E
G
S
L
P
R
A
E
S
F
A
R
Q
V
L
S
L
P
I
G
P
H
L
E
R
P
Q
A
L
R
V
I
D
A
V
R
E
W
A
E
R
V
-
69
HHSearch
80.20
34%
-70
- C1 -
4K2M
7
NTDA_BACSU
A:
[88-440]
-------------------------
N
T
L
----
T
E
V
L
P
T
G
--
K
-
F
T
S
-
G
-
P
Y
L
E
Q
F
E
K
V
L
S
T
Y
L
H
K
R
Y
V
I
A
T
S
S
G
T
D
A
I
M
I
G
L
L
--
A
L
G
--
L
N
P
G
D
E
V
I
M
P
A
N
S
F
S
A
T
E
N
A
V
L
A
S
G
G
V
P
I
Y
V
D
I
N
P
Q
T
F
C
I
D
P
D
K
I
E
E
A
I
T
P
Y
T
K
F
I
L
P
V
H
L
Y
G
K
H
S
D
M
Q
H
I
R
Q
I
A
N
R
Y
K
L
K
V
I
E
D
A
C
Q
G
I
G
L
T
-
D
---
L
G
K
Y
A
D
I
T
T
L
S
F
N
P
Y
K
N
F
G
V
C
-
G
K
A
G
A
I
A
T
D
N
E
E
L
A
K
K
C
I
Q
F
S
Y
H
G
F
E
V
N
V
K
---------
N
K
K
V
I
N
F
G
F
N
S
K
M
D
N
L
Q
A
A
I
G
L
E
R
M
K
Y
L
S
L
N
N
F
K
R
L
F
L
A
D
R
Y
--
I
T
Q
L
A
E
L
Q
N
K
--
G
Y
--
I
-
E
-
L
P
E
L
---
S
E
D
H
V
W
--
H
L
F
P
I
-
K
V
R
T
----
E
D
R
A
D
I
M
T
K
L
N
E
D
F
-
G
V
Q
T
D
V
Y
Y
-
P
I
-
L
S
-
H
MQK
T
P
L
V
Q
D
--
K
Y
A
G
L
Q
L
V
H
T
E
K
A
H
S
Q
V
L
H
L
P
L
Y
P
S
F
T
L
E
E
Q
D
R
V
M
E
G
L
F
H
V
I
K
Q
E
-
26
PsiBlast_CBE
79.15
36%
-50
- C1 -
2OGA
5
DESV_STRVZ
C:
[50-396]
---------------------------
I
----
A
R
V
L
D
S
G
--
R
-
Y
L
L
-
G
-
P
E
L
E
G
F
E
A
E
F
A
A
Y
C
E
T
D
H
A
V
G
V
N
S
G
M
D
A
L
Q
L
A
L
R
--
G
L
G
--
I
G
P
G
D
E
V
I
V
P
S
H
T
Y
I
A
S
W
L
A
V
S
A
T
G
A
T
P
V
P
V
E
P
H
E
D
H
P
T
L
D
P
L
L
V
E
K
A
I
T
P
R
T
R
A
L
L
P
V
H
L
Y
G
H
P
A
D
M
D
A
L
R
E
L
A
D
R
H
G
L
H
I
V
E
D
A
A
Q
A
H
G
A
R
Y
R
G
R
R
I
G
A
G
S
S
V
A
A
F
S
F
Y
P
G
K
N
L
G
-
C
F
G
D
G
G
A
V
V
T
G
D
P
E
L
A
E
R
L
R
M
L
R
N
Y
G
S
R
Q
K
------------
Y
S
H
E
T
K
G
T
N
S
R
L
D
E
M
Q
A
A
V
L
R
I
R
L
A
H
L
D
S
W
N
G
R
R
S
A
L
A
A
E
Y
--
L
S
G
L
A
G
L
P
----
G
I
--
G
-
L
-
P
V
T
A
--
P
D
T
D
P
V
W
--
H
L
F
T
V
-
R
T
E
R
------
R
D
E
L
R
S
H
L
-
D
-
A
R
G
I
D
T
L
T
H
Y
P
V
P
-
V
H
-
L
---
S
P
A
Y
A
G
E
-
A
P
P
E
G
S
L
P
R
A
E
S
F
A
R
Q
V
L
S
L
P
I
G
P
H
L
E
R
P
Q
A
L
R
V
I
D
A
V
R
E
W
A
E
R
V
-
25
PsiBlast_CBE
78.86
36%
-52
- C1 -
2OGA
5
DESV_STRVZ
D:
[50-396]
---------------------------
I
----
A
R
V
L
D
S
G
--
R
-
Y
L
L
-
G
-
P
E
L
E
G
F
E
A
E
F
A
A
Y
C
E
T
D
H
A
V
G
V
N
S
G
M
D
A
L
Q
L
A
L
R
--
G
L
G
--
I
G
P
G
D
E
V
I
V
P
S
H
T
Y
I
A
S
W
L
A
V
S
A
T
G
A
T
P
V
P
V
E
P
H
E
D
H
P
T
L
D
P
L
L
V
E
K
A
I
T
P
R
T
R
A
L
L
P
V
H
L
Y
G
H
P
A
D
M
D
A
L
R
E
L
A
D
R
H
G
L
H
I
V
E
D
A
A
Q
A
H
G
A
R
Y
R
G
R
R
I
G
A
G
S
S
V
A
A
F
S
F
Y
P
G
K
N
L
G
-
C
F
G
D
G
G
A
V
V
T
G
D
P
E
L
A
E
R
L
R
M
L
R
N
Y
G
S
R
Q
K
------------
Y
S
H
E
T
K
G
T
N
S
R
L
D
E
M
Q
A
A
V
L
R
I
R
L
A
H
L
D
S
W
N
G
R
R
S
A
L
A
A
E
Y
--
L
S
G
L
A
G
L
P
----
G
I
--
G
-
L
-
P
V
T
A
--
P
D
T
D
P
V
W
--
H
L
F
T
V
-
R
T
E
R
------
R
D
E
L
R
S
H
L
-
D
-
A
R
G
I
D
T
L
T
H
Y
P
V
P
-
V
H
-
L
---
S
P
A
Y
A
G
E
-
A
P
P
E
G
S
L
P
R
A
E
S
F
A
R
Q
V
L
S
L
P
I
G
P
H
L
E
R
P
Q
A
L
R
V
I
D
A
V
R
E
W
A
E
R
V
-
7
PsiBlast_PDB
78.79
36%
-48
- C1 -
2OGA
7
DESV_STRVZ
A:
[50-397]
---------------------------
I
----
A
R
V
L
D
S
G
--
R
-
Y
L
L
-
G
-
P
E
L
E
G
F
E
A
E
F
A
A
Y
C
E
T
D
H
A
V
G
V
N
S
G
M
D
A
L
Q
L
A
L
R
--
G
L
G
--
I
G
P
G
D
E
V
I
V
P
S
H
T
Y
I
A
S
W
L
A
V
S
A
T
G
A
T
P
V
P
V
E
P
H
E
D
H
P
T
L
D
P
L
L
V
E
K
A
I
T
P
R
T
R
A
L
L
P
V
H
L
Y
G
H
P
A
D
M
D
A
L
R
E
L
A
D
R
H
G
L
H
I
V
E
D
A
A
Q
A
H
G
A
R
Y
R
G
R
R
I
G
A
G
S
S
V
A
A
F
S
F
Y
P
G
K
N
L
G
-
C
F
G
D
G
G
A
V
V
T
G
D
P
E
L
A
E
R
L
R
M
L
R
N
Y
G
S
R
Q
K
------------
Y
S
H
E
T
K
G
T
N
S
R
L
D
E
M
Q
A
A
V
L
R
I
R
L
A
H
L
D
S
W
N
G
R
R
S
A
L
A
A
E
Y
--
L
S
G
L
A
G
L
P
----
G
I
--
G
-
L
-
P
V
T
A
--
P
D
T
D
P
V
W
--
H
L
F
T
V
-
R
T
E
R
------
R
D
E
L
R
S
H
L
-
D
-
A
R
G
I
D
T
L
T
H
Y
P
V
P
-
V
H
-
L
---
S
P
A
Y
A
G
E
-
A
P
P
E
G
S
L
P
R
A
E
S
F
A
R
Q
V
L
S
L
P
I
G
P
H
L
E
R
P
Q
A
L
R
V
I
D
A
V
R
E
W
A
E
R
V
D
6
PsiBlast_PDB
76.46
41%
-17
- C1 -
3DR4
2
GDPPS_CAUCR
A:
[32-390]
-------------
P
R
L
D
G
N
E
---
R
-
D
Y
V
----
L
E
C
M
D
T
T
--
W
-
I
S
S
V
G
-
R
F
I
V
E
F
E
K
A
F
A
D
Y
C
G
V
K
H
A
I
A
C
N
N
G
T
T
A
L
H
L
A
L
V
--
A
M
G
--
I
G
P
G
D
E
V
I
V
P
S
L
T
Y
I
A
S
A
N
S
V
T
Y
C
G
A
T
P
V
L
V
D
N
D
P
R
T
F
N
L
D
A
A
K
L
E
A
L
I
T
P
R
T
K
A
I
M
P
V
H
L
Y
G
Q
I
C
D
M
D
P
I
L
E
V
A
R
R
H
N
L
L
V
I
E
D
A
A
E
A
V
G
A
T
Y
R
G
K
K
S
G
S
L
G
D
C
A
T
F
S
F
F
G
N
A
I
I
T
-
T
-
G
E
G
G
M
I
T
T
N
D
D
D
L
A
A
K
M
R
L
L
R
G
Q
G
M
D
P
N
--
R
R
Y
-----
W
F
P
I
V
---
G
F
N
Y
R
M
T
N
I
Q
A
A
I
G
L
A
Q
L
E
R
V
D
E
H
L
A
A
R
E
R
V
V
G
W
Y
--
E
Q
K
L
A
R
L
G
----
N
R
--
V
-
T
K
P
H
V
A
--
L
T
G
R
H
V
F
--
W
M
Y
T
V
-
R
L
G
E
G
L
S
-
T
T
R
D
Q
V
I
K
D
L
-
D
-
A
L
G
I
E
S
R
P
V
F
-
H
P
-
M
H
-
I
---
M
P
P
Y
A
H
---
L
A
T
D
D
L
K
I
A
E
A
C
G
V
D
G
L
N
L
P
T
H
A
G
L
T
E
A
D
I
D
R
V
I
A
A
L
D
Q
V
L
----
23
PsiBlast_CBE
75.26
41%
-17
- C1 -
3DR4
2
GDPPS_CAUCR
C:
[32-390]
-------------
P
R
L
D
G
N
E
---
R
-
D
Y
V
----
L
E
C
M
D
T
T
--
W
-
I
S
S
V
G
-
R
F
I
V
E
F
E
K
A
F
A
D
Y
C
G
V
K
H
A
I
A
C
N
N
G
T
T
A
L
H
L
A
L
V
--
A
M
G
--
I
G
P
G
D
E
V
I
V
P
S
L
T
Y
I
A
S
A
N
S
V
T
Y
C
G
A
T
P
V
L
V
D
N
D
P
R
T
F
N
L
D
A
A
K
L
E
A
L
I
T
P
R
T
K
A
I
M
P
V
H
L
Y
G
Q
I
C
D
M
D
P
I
L
E
V
A
R
R
H
N
L
L
V
I
E
D
A
A
E
A
V
G
A
T
Y
R
G
K
K
S
G
S
L
G
D
C
A
T
F
S
F
F
G
N
A
I
I
T
-
T
-
G
E
G
G
M
I
T
T
N
D
D
D
L
A
A
K
M
R
L
L
R
G
Q
G
M
D
P
N
--
R
R
Y
-----
W
F
P
I
V
---
G
F
N
Y
R
M
T
N
I
Q
A
A
I
G
L
A
Q
L
E
R
V
D
E
H
L
A
A
R
E
R
V
V
G
W
Y
--
E
Q
K
L
A
R
L
G
----
N
R
--
V
-
T
K
P
H
V
A
--
L
T
G
R
H
V
F
--
W
M
Y
T
V
-
R
L
G
E
G
L
S
-
T
T
R
D
Q
V
I
K
D
L
-
D
-
A
L
G
I
E
S
R
P
V
F
-
H
P
-
M
H
-
I
---
M
P
P
Y
A
H
---
L
A
T
D
D
L
K
I
A
E
A
C
G
V
D
G
L
N
L
P
T
H
A
G
L
T
E
A
D
I
D
R
V
I
A
A
L
D
Q
V
L
----
22
PsiBlast_CBE
74.83
41%
-16
- C1 -
3DR4
2
GDPPS_CAUCR
D:
[32-390]
-------------
P
R
L
D
G
N
E
---
R
-
D
Y
V
----
L
E
C
M
D
T
T
--
W
-
I
S
S
V
G
-
R
F
I
V
E
F
E
K
A
F
A
D
Y
C
G
V
K
H
A
I
A
C
N
N
G
T
T
A
L
H
L
A
L
V
--
A
M
G
--
I
G
P
G
D
E
V
I
V
P
S
L
T
Y
I
A
S
A
N
S
V
T
Y
C
G
A
T
P
V
L
V
D
N
D
P
R
T
F
N
L
D
A
A
K
L
E
A
L
I
T
P
R
T
K
A
I
M
P
V
H
L
Y
G
Q
I
C
D
M
D
P
I
L
E
V
A
R
R
H
N
L
L
V
I
E
D
A
A
E
A
V
G
A
T
Y
R
G
K
K
S
G
S
L
G
D
C
A
T
F
S
F
F
G
N
A
I
I
T
-
T
-
G
E
G
G
M
I
T
T
N
D
D
D
L
A
A
K
M
R
L
L
R
G
Q
G
M
D
P
N
--
R
R
Y
-----
W
F
P
I
V
---
G
F
N
Y
R
M
T
N
I
Q
A
A
I
G
L
A
Q
L
E
R
V
D
E
H
L
A
A
R
E
R
V
V
G
W
Y
--
E
Q
K
L
A
R
L
G
----
N
R
--
V
-
T
K
P
H
V
A
--
L
T
G
R
H
V
F
--
W
M
Y
T
V
-
R
L
G
E
G
L
S
-
T
T
R
D
Q
V
I
K
D
L
-
D
-
A
L
G
I
E
S
R
P
V
F
-
H
P
-
M
H
-
I
---
M
P
P
Y
A
H
---
L
A
T
D
D
L
K
I
A
E
A
C
G
V
D
G
L
N
L
P
T
H
A
G
L
T
E
A
D
I
D
R
V
I
A
A
L
D
Q
V
L
----
24
PsiBlast_CBE
74.76
41%
-16
- C1 -
3DR4
4
GDPPS_CAUCR
B:
[32-390]
-------------
P
R
L
D
G
N
E
---
R
-
D
Y
V
----
L
E
C
M
D
T
T
--
W
-
I
S
S
V
G
-
R
F
I
V
E
F
E
K
A
F
A
D
Y
C
G
V
K
H
A
I
A
C
N
N
G
T
T
A
L
H
L
A
L
V
--
A
M
G
--
I
G
P
G
D
E
V
I
V
P
S
L
T
Y
I
A
S
A
N
S
V
T
Y
C
G
A
T
P
V
L
V
D
N
D
P
R
T
F
N
L
D
A
A
K
L
E
A
L
I
T
P
R
T
K
A
I
M
P
V
H
L
Y
G
Q
I
C
D
M
D
P
I
L
E
V
A
R
R
H
N
L
L
V
I
E
D
A
A
E
A
V
G
A
T
Y
R
G
K
K
S
G
S
L
G
D
C
A
T
F
S
F
F
G
N
A
I
I
T
-
T
-
G
E
G
G
M
I
T
T
N
D
D
D
L
A
A
K
M
R
L
L
R
G
Q
G
M
D
P
N
--
R
R
Y
-----
W
F
P
I
V
---
G
F
N
Y
R
M
T
N
I
Q
A
A
I
G
L
A
Q
L
E
R
V
D
E
H
L
A
A
R
E
R
V
V
G
W
Y
--
E
Q
K
L
A
R
L
G
----
N
R
--
V
-
T
K
P
H
V
A
--
L
T
G
R
H
V
F
--
W
M
Y
T
V
-
R
L
G
E
G
L
S
-
T
T
R
D
Q
V
I
K
D
L
-
D
-
A
L
G
I
E
S
R
P
V
F
-
H
P
-
M
H
-
I
---
M
P
P
Y
A
H
---
L
A
T
D
D
L
K
I
A
E
A
C
G
V
D
G
L
N
L
P
T
H
A
G
L
T
E
A
D
I
D
R
V
I
A
A
L
D
Q
V
L
----
15
PsiBlast_PDB
69.98
37%
-20
- C1 -
2PO3
2
?
A:
[36-380]
-------------------------
E
R
L
----
D
R
A
L
D
S
Q
--
W
-
L
S
N
-
G
G
P
L
V
R
E
F
E
E
R
V
A
G
L
A
G
V
R
H
A
V
A
T
C
N
A
T
A
G
L
Q
L
L
A
H
--
A
A
G
--
L
T
--
G
E
V
I
M
P
S
M
T
F
A
A
T
P
H
A
L
R
W
I
G
L
T
P
V
F
A
D
I
D
P
D
T
G
N
L
D
P
D
Q
V
A
A
A
V
T
P
R
T
S
A
V
V
G
V
H
L
W
G
R
P
C
A
A
D
Q
L
R
K
V
A
D
E
H
G
L
R
L
Y
F
D
A
A
H
A
L
G
C
A
V
D
G
R
P
A
G
S
L
G
D
A
E
V
F
S
F
H
A
T
K
A
V
N
-
A
-
F
E
G
G
A
V
V
T
D
D
A
D
L
A
A
R
I
R
A
L
H
N
F
G
F
D
L
-------
P
G
G
S
-----
P
A
G
G
T
N
A
K
M
S
E
A
A
A
A
M
G
L
T
S
L
D
A
F
P
E
V
I
D
R
N
R
R
N
H
A
A
Y
--
R
E
H
L
A
D
L
P
----
G
V
--
L
-----
V
A
--
D
H
D
R
H
G
L
NN
H
Q
Y
V
I
V
E
I
D
E
A
T
T
G
I
H
R
D
L
V
M
E
V
L
K
A
-
E
-
G
V
H
T
R
A
Y
F
-
S
P
G
C
H
E
L
---
E
P
Y
R
----
G
Q
P
H
A
P
L
P
H
T
E
R
L
A
A
R
V
L
S
L
P
T
G
T
A
I
G
D
D
D
I
R
R
V
A
D
L
L
R
-------
34
PsiBlast_CBE
67.91
37%
-16
- C1 -
2PO3
2
?
B:
[36-380]
-------------------------
E
R
L
----
D
R
A
L
D
S
Q
--
W
-
L
S
N
-
G
G
P
L
V
R
E
F
E
E
R
V
A
G
L
A
G
V
R
H
A
V
A
T
C
N
A
T
A
G
L
Q
L
L
A
H
--
A
A
G
--
L
T
--
G
E
V
I
M
P
S
M
T
F
A
A
T
P
H
A
L
R
W
I
G
L
T
P
V
F
A
D
I
D
P
D
T
G
N
L
D
P
D
Q
V
A
A
A
V
T
P
R
T
S
A
V
V
G
V
H
L
W
G
R
P
C
A
A
D
Q
L
R
K
V
A
D
E
H
G
L
R
L
Y
F
D
A
A
H
A
L
G
C
A
V
D
G
R
P
A
G
S
L
G
D
A
E
V
F
S
F
H
A
T
K
A
V
N
-
A
-
F
E
G
G
A
V
V
T
D
D
A
D
L
A
A
R
I
R
A
L
H
N
F
G
F
D
L
-------
P
G
G
S
-----
P
A
G
G
T
N
A
K
M
S
E
A
A
A
A
M
G
L
T
S
L
D
A
F
P
E
V
I
D
R
N
R
R
N
H
A
A
Y
--
R
E
H
L
A
D
L
P
----
G
V
--
L
-----
V
A
--
D
H
D
R
H
G
L
NN
H
Q
Y
V
I
V
E
I
D
E
A
T
T
G
I
H
R
D
L
V
M
E
V
L
K
A
-
E
-
G
V
H
T
R
A
Y
F
-
S
P
G
C
H
E
L
---
E
P
Y
R
----
G
Q
P
H
A
P
L
P
H
T
E
R
L
A
A
R
V
L
S
L
P
T
G
T
A
I
G
D
D
D
I
R
R
V
A
D
L
L
R
-------
68
HHSearch
66.66
32%
3
- C1 -
3UWC
6
?
A:
[4-371]
------
M
R
V
P
Y
S
Y
L
E
R
Q
F
A
D
I
E
P
Y
L
N
D
L
----
R
E
F
I
K
T
A
--
D
-
F
T
L
-
G
-
A
E
L
E
K
F
E
K
R
F
A
A
L
H
N
A
P
H
A
I
G
V
G
T
G
T
D
A
L
A
M
S
F
K
--
M
L
N
--
I
G
A
G
D
E
V
I
T
C
A
N
T
F
I
A
S
V
G
A
I
V
Q
A
G
A
T
P
V
L
V
D
S
E
N
-
G
Y
V
I
D
P
E
K
I
E
A
A
I
T
D
K
T
K
A
I
M
P
V
H
Y
T
G
N
I
A
D
M
P
A
L
A
K
I
A
K
K
H
N
L
H
I
V
E
D
A
C
Q
T
I
L
G
R
I
N
D
K
F
V
G
S
W
G
Q
F
A
C
F
S
L
H
P
L
K
N
L
N
V
W
-
S
D
A
G
V
I
I
T
H
S
D
E
Y
A
E
K
L
R
L
Y
R
N
H
G
L
I
N
R
------------
D
V
C
V
E
Y
G
I
N
C
R
M
D
T
I
Q
A
V
I
A
N
R
L
M
N
Q
L
E
T
I
T
E
K
R
R
G
I
A
H
L
Y
--
D
Q
S
F
V
D
L
S
----
E
F
I
-
D
-
V
-
P
V
R
R
--
E
G
V
Y
H
V
F
--
H
I
Y
V
L
-
R
V
K
------
Y
R
D
Q
L
F
Q
Y
L
K
D
-
N
-
G
I
E
V
K
I
H
Y
P
I
A
-
M
H
-
L
---
Q
P
A
A
K
S
L
-
G
Y
Q
Q
G
D
F
P
M
A
E
K
H
G
E
A
V
I
T
L
P
A
H
P
Y
L
T
E
E
E
I
N
Y
I
I
K
K
V
R
E
F
Y
L
E
K
-
32
PsiBlast_CBE
66.02
33%
24
- C1 -
4K2M
8
NTDA_BACSU
B:
[71-438]
-------
F
L
P
V
D
-
R
L
I
T
N
D
E
---
V
-
E
D
I
L
N
T
L
T
E
V
L
P
T
G
--
K
-
F
T
S
-
G
-
P
Y
L
E
Q
F
E
K
V
L
S
T
Y
L
H
K
R
Y
V
I
A
T
S
S
G
T
D
A
I
M
I
G
L
L
--
A
L
G
--
L
N
P
G
D
E
V
I
M
P
A
N
S
F
S
A
T
E
N
A
V
L
A
S
G
G
V
P
I
Y
V
D
I
N
P
Q
T
F
C
I
D
P
D
K
I
E
E
A
I
T
P
Y
T
K
F
I
L
P
V
H
L
Y
G
K
H
S
D
M
Q
H
I
R
Q
I
A
N
R
Y
K
L
K
V
I
E
D
A
C
Q
G
I
G
L
T
----
D
L
G
K
Y
A
D
I
T
T
L
S
F
N
P
Y
K
N
F
G
V
C
-
G
K
A
G
A
I
A
T
D
N
E
E
L
A
K
K
C
I
Q
F
S
Y
H
G
F
E
V
N
V
K
N
K
---------
K
V
I
N
F
G
F
N
S
K
M
D
N
L
Q
A
A
I
G
L
E
R
M
K
Y
L
S
L
N
N
F
K
R
L
F
L
A
D
R
Y
I
T
Q
L
A
E
L
Q
N
K
----
G
Y
--
I
E
L
-
P
E
L
S
--
E
D
--
H
V
W
--
H
L
F
P
I
-
K
V
R
T
E
D
----
R
A
D
I
M
T
K
L
N
E
-
D
F
G
V
Q
T
D
V
Y
Y
P
I
L
-
S
H
-
M
---
Q
K
T
P
L
V
Q
D
K
Y
A
G
L
Q
L
V
H
T
E
K
A
H
S
Q
V
L
H
L
P
L
Y
P
S
F
T
L
E
E
Q
D
R
V
M
E
G
L
F
H
V
I
K
---
33
PsiBlast_CBE
65.33
33%
23
- C1 -
4K2I
12
NTDA_BACSU
B:
[71-438]
-------
F
L
P
V
D
-
R
L
I
T
N
D
E
---
V
-
E
D
I
L
N
T
L
T
E
V
L
P
T
G
--
K
-
F
T
S
-
G
-
P
Y
L
E
Q
F
E
K
V
L
S
T
Y
L
H
K
R
Y
V
I
A
T
S
S
G
T
D
A
I
M
I
G
L
L
--
A
L
G
--
L
N
P
G
D
E
V
I
M
P
A
N
S
F
S
A
T
E
N
A
V
L
A
S
G
G
V
P
I
Y
V
D
I
N
P
Q
T
F
C
I
D
P
D
K
I
E
E
A
I
T
P
Y
T
K
F
I
L
P
V
H
L
Y
G
K
H
S
D
M
Q
H
I
R
Q
I
A
N
R
Y
K
L
K
V
I
E
D
A
C
Q
G
I
G
L
T
----
D
L
G
K
Y
A
D
I
T
T
L
S
F
N
P
Y
K
N
F
G
V
C
-
G
K
A
G
A
I
A
T
D
N
E
E
L
A
K
K
C
I
Q
F
S
Y
H
G
F
E
V
N
V
K
N
K
---------
K
V
I
N
F
G
F
N
S
K
M
D
N
L
Q
A
A
I
G
L
E
R
M
K
Y
L
S
L
N
N
F
K
R
L
F
L
A
D
R
Y
I
T
Q
L
A
E
L
Q
N
K
----
G
Y
--
I
E
L
-
P
E
L
S
--
E
D
--
H
V
W
--
H
L
F
P
I
-
K
V
R
T
E
D
----
R
A
D
I
M
T
K
L
N
E
-
D
F
G
V
Q
T
D
V
Y
Y
P
I
L
-
S
H
-
M
---
Q
K
T
P
L
V
Q
D
K
Y
A
G
L
Q
L
V
H
T
E
K
A
H
S
Q
V
L
H
L
P
L
Y
P
S
F
T
L
E
E
Q
D
R
V
M
E
G
L
F
H
V
I
K
---
53
HHSearch
65.06
32%
6
- C1 -
2FNU
4
PSEC_HELPY
A:
[3-372]
-------
E
F
A
Y
S
E
P
C
L
D
K
E
D
---
K
-
K
A
V
----
L
E
V
L
N
S
K
--
Q
-
L
T
Q
-
G
-
K
R
S
L
L
F
E
E
A
L
C
E
F
L
G
V
K
H
A
L
V
F
N
S
A
T
S
A
L
L
T
L
Y
R
--
N
F
S
EF
S
A
D
R
N
E
I
I
T
T
P
I
S
F
V
A
T
A
N
M
L
L
E
S
G
Y
T
P
V
F
A
G
I
K
N
-
D
G
N
I
D
E
L
A
L
E
K
L
I
N
E
R
T
K
A
I
V
S
V
D
Y
A
G
K
S
V
E
V
E
S
V
Q
K
L
C
K
K
H
S
L
S
F
L
S
D
S
S
H
A
L
G
S
E
Y
Q
N
K
K
V
G
G
F
A
L
A
S
V
F
S
F
H
A
I
K
P
I
T
-
T
-
A
E
G
G
A
V
V
T
N
D
S
E
L
H
E
K
M
K
L
F
R
S
H
G
M
L
K
K
D
F
--------
F
E
G
E
V
K
S
I
G
H
N
F
R
L
N
E
I
Q
S
A
L
G
L
S
Q
L
K
K
A
P
F
L
M
Q
K
R
E
E
A
A
L
T
Y
--
D
R
I
F
K
D
N
P
----
Y
F
--
T
-
P
-
L
H
P
L
--
L
K
D
K
S
S
N
--
H
L
Y
P
I
-
L
M
H
Q
K
F
-
F
T
C
K
K
L
I
L
E
S
L
H
K
-
R
-
G
I
L
A
Q
V
H
Y
-
K
P
-
I
Y
-
Q
---
Y
Q
L
Y
Q
Q
L
--
F
N
T
A
P
L
K
S
A
E
D
F
Y
H
A
E
I
S
L
P
C
H
A
N
L
N
L
E
S
V
Q
N
I
A
H
S
V
L
K
T
F
E
S
F
-
13
PsiBlast_PDB
65.00
33%
25
- C1 -
4K2I
13
NTDA_BACSU
A:
[71-438]
-------
F
L
P
V
D
-
R
L
I
T
N
D
E
---
V
-
E
D
I
L
N
T
L
T
E
V
L
P
T
G
--
K
-
F
T
S
-
G
-
P
Y
L
E
Q
F
E
K
V
L
S
T
Y
L
H
K
R
Y
V
I
A
T
S
S
G
T
D
A
I
M
I
G
L
L
--
A
L
G
--
L
N
P
G
D
E
V
I
M
P
A
N
S
F
S
A
T
E
N
A
V
L
A
S
G
G
V
P
I
Y
V
D
I
N
P
Q
T
F
C
I
D
P
D
K
I
E
E
A
I
T
P
Y
T
K
F
I
L
P
V
H
L
Y
G
K
H
S
D
M
Q
H
I
R
Q
I
A
N
R
Y
K
L
K
V
I
E
D
A
C
Q
G
I
G
L
T
----
D
L
G
K
Y
A
D
I
T
T
L
S
F
N
P
Y
K
N
F
G
V
C
-
G
K
A
G
A
I
A
T
D
N
E
E
L
A
K
K
C
I
Q
F
S
Y
H
G
F
E
V
N
V
K
N
K
---------
K
V
I
N
F
G
F
N
S
K
M
D
N
L
Q
A
A
I
G
L
E
R
M
K
Y
L
S
L
N
N
F
K
R
L
F
L
A
D
R
Y
I
T
Q
L
A
E
L
Q
N
K
----
G
Y
--
I
E
L
-
P
E
L
S
--
E
D
--
H
V
W
--
H
L
F
P
I
-
K
V
R
T
E
D
----
R
A
D
I
M
T
K
L
N
E
-
D
F
G
V
Q
T
D
V
Y
Y
P
I
L
-
S
H
-
M
---
Q
K
T
P
L
V
Q
D
K
Y
A
G
L
Q
L
V
H
T
E
K
A
H
S
Q
V
L
H
L
P
L
Y
P
S
F
T
L
E
E
Q
D
R
V
M
E
G
L
F
H
V
I
K
---
12
PsiBlast_PDB
64.13
32%
-6
- C1 -
2FNU
4
PSEC_HELPY
A:
[6-365]
----------
Y
S
E
P
C
L
D
K
E
D
---
K
-
K
A
V
----
L
E
V
L
N
S
K
--
Q
-
L
T
Q
-
G
-
K
R
S
L
L
F
E
E
A
L
C
E
F
L
G
V
K
H
A
L
V
F
N
S
A
T
S
A
L
L
T
L
Y
R
N
F
S
E
F
--
S
A
D
R
N
E
I
I
T
T
P
I
S
F
V
A
T
A
N
M
L
L
E
S
G
Y
T
P
V
F
A
G
I
-
K
N
D
G
N
I
D
E
L
A
L
E
K
L
I
N
E
R
T
K
A
I
V
S
V
D
Y
A
G
K
S
V
E
V
E
S
V
Q
K
L
C
K
K
H
S
L
S
F
L
S
D
S
S
H
A
L
G
S
E
Y
Q
N
K
K
V
G
G
F
A
L
A
S
V
F
S
F
H
A
I
K
P
I
T
-
T
-
A
E
G
G
A
V
V
T
N
D
S
E
L
H
E
K
M
K
L
F
R
S
H
G
M
L
K
K
D
F
--------
F
E
G
E
V
K
S
I
G
H
N
F
R
L
N
E
I
Q
S
A
L
G
L
S
Q
L
K
K
A
P
F
L
M
Q
K
R
E
E
A
A
L
T
Y
--
D
R
I
F
K
D
N
P
----
Y
F
TP
L
-
H
-
P
L
L
K
--
D
--
K
S
S
N
--
H
L
Y
P
I
-
L
M
H
Q
K
--
F
F
T
C
K
K
L
I
L
E
S
L
H
-
K
R
G
I
L
A
Q
V
H
Y
-
K
P
-
I
Y
-
Q
---
Y
Q
L
Y
Q
Q
L
F
N
--
T
A
P
L
K
S
A
E
D
F
Y
H
A
E
I
S
L
P
C
H
A
N
L
N
L
E
S
V
Q
N
I
A
H
S
V
--------
29
PsiBlast_CBE
63.88
32%
-7
- C1 -
2FNU
4
PSEC_HELPY
B:
[6-365]
----------
Y
S
E
P
C
L
D
K
E
D
---
K
-
K
A
V
----
L
E
V
L
N
S
K
--
Q
-
L
T
Q
-
G
-
K
R
S
L
L
F
E
E
A
L
C
E
F
L
G
V
K
H
A
L
V
F
N
S
A
T
S
A
L
L
T
L
Y
R
NF
S
E
F
--
S
A
D
R
N
E
I
I
T
T
P
I
S
F
V
A
T
A
N
M
L
L
E
S
G
Y
T
P
V
F
A
G
I
-
K
N
D
G
N
I
D
E
L
A
L
E
K
L
I
N
E
R
T
K
A
I
V
S
V
D
Y
A
G
K
S
V
E
V
E
S
V
Q
K
L
C
K
K
H
S
L
S
F
L
S
D
S
S
H
A
L
G
S
E
Y
Q
N
K
K
V
G
G
F
A
L
A
S
V
F
S
F
H
A
I
K
P
I
T
-
T
-
A
E
G
G
A
V
V
T
N
D
S
E
L
H
E
K
M
K
L
F
R
S
H
G
M
L
K
K
D
F
--------
F
E
G
E
V
K
S
I
G
H
N
F
R
L
N
E
I
Q
S
A
L
G
L
S
Q
L
K
K
A
P
F
L
M
Q
K
R
E
E
A
A
L
T
Y
--
D
R
I
F
K
D
N
P
----
Y
F
TP
L
-
H
-
P
L
L
K
--
D
--
K
S
S
N
--
H
L
Y
P
I
-
L
M
H
Q
K
--
F
F
T
C
K
K
L
I
L
E
S
L
H
-
K
R
G
I
L
A
Q
V
H
Y
-
K
P
-
I
Y
-
Q
---
Y
Q
L
Y
Q
Q
L
F
N
--
T
A
P
L
K
S
A
E
D
F
Y
H
A
E
I
S
L
P
C
H
A
N
L
N
L
E
S
V
Q
N
I
A
H
S
V
--------
30
PsiBlast_CBE
62.63
32%
-7
- C1 -
2FNI
2
PSEC_HELPY
B:
[6-365]
----------
Y
S
E
P
C
L
D
K
E
D
---
K
-
K
A
V
----
L
E
V
L
N
S
K
--
Q
-
L
T
Q
-
G
-
K
R
S
L
L
F
E
E
A
L
C
E
F
L
G
V
K
H
A
L
V
F
N
S
A
T
S
A
L
L
T
L
Y
R
NF
S
E
F
--
S
A
D
R
N
E
I
I
T
T
P
I
S
F
V
A
T
A
N
M
L
L
E
S
G
Y
T
P
V
F
A
G
I
-
K
N
D
G
N
I
D
E
L
A
L
E
K
L
I
N
E
R
T
K
A
I
V
S
V
D
Y
A
G
K
S
V
E
V
E
S
V
Q
K
L
C
K
K
H
S
L
S
F
L
S
D
S
S
H
A
L
G
S
E
Y
Q
N
K
K
V
G
G
F
A
L
A
S
V
F
S
F
H
A
I
K
P
I
T
-
T
-
A
E
G
G
A
V
V
T
N
D
S
E
L
H
E
K
M
K
L
F
R
S
H
G
M
L
K
K
D
F
--------
F
E
G
E
V
K
S
I
G
H
N
F
R
L
N
E
I
Q
S
A
L
G
L
S
Q
L
K
K
A
P
F
L
M
Q
K
R
E
E
A
A
L
T
Y
--
D
R
I
F
K
D
N
P
----
Y
F
TP
L
-
H
-
P
L
L
K
--
D
--
K
S
S
N
--
H
L
Y
P
I
-
L
M
H
Q
K
--
F
F
T
C
K
K
L
I
L
E
S
L
H
-
K
R
G
I
L
A
Q
V
H
Y
-
K
P
-
I
Y
-
Q
---
Y
Q
L
Y
Q
Q
L
F
N
--
T
A
P
L
K
S
A
E
D
F
Y
H
A
E
I
S
L
P
C
H
A
N
L
N
L
E
S
V
Q
N
I
A
H
S
V
--------
11
PsiBlast_PDB
61.57
32%
-9
- C1 -
2FNI
2
PSEC_HELPY
A:
[6-365]
----------
Y
S
E
P
C
L
D
K
E
D
---
K
-
K
A
V
----
L
E
V
L
N
S
K
--
Q
-
L
T
Q
-
G
-
K
R
S
L
L
F
E
E
A
L
C
E
F
L
G
V
K
H
A
L
V
F
N
S
A
T
S
A
L
L
T
L
Y
R
N
F
S
E
F
--
S
A
D
R
N
E
I
I
T
T
P
I
S
F
V
A
T
A
N
M
L
L
E
S
G
Y
T
P
V
F
A
G
I
-
K
N
D
G
N
I
D
E
L
A
L
E
K
L
I
N
E
R
T
K
A
I
V
S
V
D
Y
A
G
K
S
V
E
V
E
S
V
Q
K
L
C
K
K
H
S
L
S
F
L
S
D
S
S
H
A
L
G
S
E
Y
Q
N
K
K
V
G
G
F
A
L
A
S
V
F
S
F
H
A
I
K
P
I
T
-
T
-
A
E
G
G
A
V
V
T
N
D
S
E
L
H
E
K
M
K
L
F
R
S
H
G
M
L
K
K
D
F
--------
F
E
G
E
V
K
S
I
G
H
N
F
R
L
N
E
I
Q
S
A
L
G
L
S
Q
L
K
K
A
P
F
L
M
Q
K
R
E
E
A
A
L
T
Y
--
D
R
I
F
K
D
N
P
----
Y
F
TP
L
-
H
-
P
L
L
K
--
D
--
K
S
S
N
--
H
L
Y
P
I
-
L
M
H
Q
K
--
F
F
T
C
K
K
L
I
L
E
S
L
H
-
K
R
G
I
L
A
Q
V
H
Y
-
K
P
-
I
Y
-
Q
---
Y
Q
L
Y
Q
Q
L
F
N
--
T
A
P
L
K
S
A
E
D
F
Y
H
A
E
I
S
L
P
C
H
A
N
L
N
L
E
S
V
Q
N
I
A
H
S
V
--------
49
PsiBlast_CBE
27.46
35%
-1
- C1 -
1B9I
1
RIFK_AMYMS
A:
[11-261]
-----------
A
W
P
Q
Y
D
D
A
E
---
R
-
N
G
L
----
V
R
A
L
E
Q
G
QW
W
-
R
M
G
-
G
-
D
E
V
N
S
F
E
R
E
F
A
A
H
H
G
A
A
H
A
L
A
V
T
N
G
T
H
A
L
E
L
A
L
Q
--
V
M
G
--
V
G
P
G
T
E
V
I
V
P
A
F
T
F
I
S
S
S
Q
A
A
Q
R
L
G
A
V
T
V
P
V
D
V
D
A
A
T
Y
N
L
D
P
E
A
V
A
A
A
V
T
P
R
T
K
V
I
M
P
V
H
M
A
G
L
M
A
D
M
D
A
L
A
K
I
S
A
D
T
G
V
P
L
L
Q
D
A
A
H
A
H
G
A
R
W
Q
G
K
R
V
G
E
L
D
S
I
A
T
F
S
F
Q
N
G
K
L
M
T
-
A
-
G
E
G
G
A
V
V
F
P
D
G
E
T
E
K
Y
E
T
A
F
L
R
H
S
C
G
R
P
R
D
D
R
-----
R
Y
F
H
K
I
A
G
S
N
M
R
L
N
E
F
--
S
A
S
V
L
R
A
Q
L
A
R
L
D
E
Q
I
A
V
R
D
E
------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
25.57
35%
-0
- C1 -
1B9H
1
RIFK_AMYMS
A:
[11-261]
-----------
A
W
P
Q
Y
D
D
A
E
---
R
-
N
G
L
----
V
R
A
L
E
Q
G
QW
W
-
R
M
G
-
G
-
D
E
V
N
S
F
E
R
E
F
A
A
H
H
G
A
A
H
A
L
A
V
T
N
G
T
H
A
L
E
L
A
L
Q
--
V
M
G
--
V
G
P
G
T
E
V
I
V
P
A
F
T
F
I
S
S
S
Q
A
A
Q
R
L
G
A
V
T
V
P
V
D
V
D
A
A
T
Y
N
L
D
P
E
A
V
A
A
A
V
T
P
R
T
K
V
I
M
P
V
H
M
A
G
L
M
A
D
M
D
A
L
A
K
I
S
A
D
T
G
V
P
L
L
Q
D
A
A
H
A
H
G
A
R
W
Q
G
K
R
V
G
E
L
D
S
I
A
T
F
S
F
Q
N
G
K
L
M
T
-
A
-
G
E
G
G
A
V
V
F
P
D
G
E
T
E
K
Y
E
T
A
F
L
R
H
S
C
-----
G
R
P
R
D
D
R
R
Y
F
H
K
I
A
G
S
N
M
R
L
N
E
F
--
S
A
S
V
L
R
A
Q
L
A
R
L
D
E
Q
I
A
V
R
D
E
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