@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu38500: (2016-08-04 )
MKLLHAIQTHAETYPQTDAFRSQGQSLTYQELWEQSDRAAAAIQKRISGEKKSPILVYGHMEPHMIVSFLGSVKAGHPYIPVDLSIPSERIAKIIESSGAELLIHAAGLSIDAVGQQIQTVSAEELLENEGGSVSQDQWVKEHETFYIIYTSGSTGNPKGVQISAANLQSFTDWICADFPVSGGKIFLNQAPFSFDLSVMDLYPCLQSGGTLHCVTKDAVNKPKVLFEELKKSGLNVWTSTPSFVQMCLMDPGFSQDLLPHADTFMFCGEVLPVSVAKALLERFPKAKIFNTYGPTEATVAVTSVEITNDVISRSESLPVGFAKPDMNIFIMDEEGQPLPEGEKGEIVIAGPSVSRGYLGEPELTEKAFFSHEGQWAYRTGDAGFIQDGQIFCQGRLDFQIKLHGYRMELEEIEFHVRQSQYVRSAVVIPYQPNGTVEYLIAAIVPEEHEFEKEFQLTSAIKKELAASLPAYMIPRKFIYQDHIQMTANGKIDRKRIGEEVLV
Atome Classification :
(22 SA)
---------.........10........20........30........40.-.......-50........60........70........80........90....-....100...------....110-....---.---..-.------120-.----....----..-.130---------.----........140--...-----......150.......160.......170.-.....--.-180.......190.......200........210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.....-----..-----340........350.......360.......370----.----......380-..-...-..390.......400.......410.......420.......430------.....--...440......---.-450.......460........470.......480.......490.......500.-------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------
M
K
L
L
H
A
I
Q
T
H
A
ETYPQ
T
D
A
F
R
SQGQSL
T
Y
Q
E
L
W
E
QS
D
R
A
A
A
A
-
I
Q
K
R
ISG-EKKS
P
I
L
V
Y
GHM
E
P
H
M
I
V
S
F
L
G
SVKAGH
P
Y
I
P
V
DLSI
P
S
E
R
I
A
K
I
I
-ESSG
A
E
L
L
I
H
------AAGL
S
I
--
D
A
V
G
---
Q
---
Q
I
-Q------TV--
S
----
A
E
E
L
----
L
E
-NE-----------G----GSV
S
Q
D
Q
W
V----KEH-----
E
T
F
Y
I
I
Y
TSGSTGNPK
G
V
Q
I
S
A
A
N
L
Q
S
F
T
D
-
W
I
CAD--F-PVSG
G
K
I
F
L
NQAPFSF
D
L
S
V
M
D
-
L
Y
P
C
L
QSG
G
T
L
H
C
V
TKDAVNK
P
K
V
L
F
E
E
L
K
KSG
L
N
V
WTS
T
P
S
F
V
Q
M
C
LMDPGFSQDLLPHA
D
T
F
M
F
C
GEV
L
P
V
S
V
A
K
A
L
L
E
RFPKA
K
I
F
NTYGPT
E
A
T
V
A
V
T
S
V
E
I
T
N
D
V
I
SRSESLPVGFAKPD
M
N
I
F
I
MDEEGQ-----PL-----P-EGEKG
E
I
V
I
AGPSVSRGYLGE
P
E
L
T
E
K
A
F
FSH----E----G
Q
W
A
Y
RTGD-AG-FIQ-D
G
Q
I
F
C
QG
R
L
D
F
Q
I
K
L
H
G
Y
R
M
E
L
E
E
I
E
F
H
V
R
Q
S
QYV
R
S
A
V
V
I
P
-Y------QPN
G
T
--
V
E
Y
L
I
A
A
IVPE
E
---
H
-
E
F
E
K
E
F
Q
L
T
S
A
-
I
K
K
E
L
A
A
SL
P
A
Y
M
I
P
R
K
F
I
Y
Q
D
H
I
Q
M
TANGKI
D
R
K
R
IGEEVLV-------------------------------------------------------------------------------
2
PsiBlast_PDB
99.59
100%
-110
- C2 -
3E7X
1
DLTA_BACSU
A:
[1-503]
---------
M
K
L
L
H
A
I
Q
T
H
A
E
T
Y
P
Q
T
D
A
F
R
S
Q
G
Q
S
L
T
Y
Q
E
L
W
E
Q
S
D
R
A
A
A
A
-
I
Q
K
R
I
S
G
-
E
K
K
S
P
I
L
V
Y
G
H
M
E
P
H
M
I
V
S
F
L
G
S
V
K
A
G
H
P
Y
I
P
V
D
L
S
I
P
S
E
R
I
A
K
I
I
-
E
S
S
G
A
E
L
L
I
H
------
A
A
G
L
S
I
--
D
A
V
G
---
Q
---
Q
I
-
Q
------
T
V
--
S
----
A
E
E
L
----
L
E
-
N
E
-----------
G
----
G
S
V
S
Q
D
Q
W
V
----
K
E
H
-----
E
T
F
Y
I
I
Y
T
S
G
S
T
G
N
P
K
G
V
Q
I
S
A
A
N
L
Q
S
F
T
D
-
W
I
C
A
D
--
F
-
P
V
S
G
G
K
I
F
L
N
Q
A
P
F
S
F
D
L
S
V
M
D
-
L
Y
P
C
L
Q
S
G
G
T
L
H
C
V
T
K
D
A
V
N
K
P
K
V
L
F
E
E
L
K
K
S
G
L
N
V
W
T
S
T
P
S
F
V
Q
M
C
L
M
D
P
G
F
S
Q
D
L
L
P
H
A
D
T
F
M
F
C
G
E
V
L
P
V
S
V
A
K
A
L
L
E
R
F
P
K
A
K
I
F
N
T
Y
G
P
T
E
A
T
V
A
V
T
S
V
E
I
T
N
D
V
I
S
R
S
E
S
L
P
V
G
F
A
K
P
D
M
N
I
F
I
M
D
E
E
G
Q
-----
P
L
-----
P
-
E
G
E
K
G
E
I
V
I
A
G
P
S
V
S
R
G
Y
L
G
E
P
E
L
T
E
K
A
F
F
S
H
----
E
----
G
Q
W
A
Y
R
T
G
D
-
A
G
-
F
I
Q
-
D
G
Q
I
F
C
Q
G
R
L
D
F
Q
I
K
L
H
G
Y
R
M
E
L
E
E
I
E
F
H
V
R
Q
S
Q
Y
V
R
S
A
V
V
I
P
-
Y
------
Q
P
N
G
T
--
V
E
Y
L
I
A
A
I
V
P
E
E
---
H
-
E
F
E
K
E
F
Q
L
T
S
A
-
I
K
K
E
L
A
A
S
L
P
A
Y
M
I
P
R
K
F
I
Y
Q
D
H
I
Q
M
T
A
N
G
K
I
D
R
K
R
I
G
E
E
V
L
V
-------------------------------------------------------------------------------
1
PsiBlast_PDB
98.95
100%
-109
- C2 -
3E7W
2
DLTA_BACSU
A:
[1-503]
---------
M
K
L
L
H
A
I
Q
T
H
A
E
T
Y
P
Q
T
D
A
F
R
S
Q
G
Q
S
L
T
Y
Q
E
L
W
E
Q
S
D
R
A
A
A
A
-
I
Q
K
R
I
S
G
-
E
K
K
S
P
I
L
V
Y
G
H
M
E
P
H
M
I
V
S
F
L
G
S
V
K
A
G
H
P
Y
I
P
V
D
L
S
I
P
S
E
R
I
A
K
I
I
-
E
S
S
G
A
E
L
L
I
H
------
A
A
G
L
S
I
--
D
A
V
G
---
Q
---
Q
I
-
Q
------
T
V
--
S
----
A
E
E
L
----
L
E
-
N
E
-----------
G
----
G
S
V
S
Q
D
Q
W
V
----
K
E
H
-----
E
T
F
Y
I
I
Y
T
S
G
S
T
G
N
P
K
G
V
Q
I
S
A
A
N
L
Q
S
F
T
D
-
W
I
C
A
D
--
F
-
P
V
S
G
G
K
I
F
L
N
Q
A
P
F
S
F
D
L
S
V
M
D
-
L
Y
P
C
L
Q
S
G
G
T
L
H
C
V
T
K
D
A
V
N
K
P
K
V
L
F
E
E
L
K
K
S
G
L
N
V
W
T
S
T
P
S
F
V
Q
M
C
L
M
D
P
G
F
S
Q
D
L
L
P
H
A
D
T
F
M
F
C
G
E
V
L
P
V
S
V
A
K
A
L
L
E
R
F
P
K
A
K
I
F
N
T
Y
G
P
T
E
A
T
V
A
V
T
S
V
E
I
T
N
D
V
I
S
R
S
E
S
L
P
V
G
F
A
K
P
D
M
N
I
F
I
M
D
E
E
G
Q
-----
P
L
-----
P
-
E
G
E
K
G
E
I
V
I
A
G
P
S
V
S
R
G
Y
L
G
E
P
E
L
T
E
K
A
F
F
S
H
----
E
----
G
Q
W
A
Y
R
T
G
D
-
A
G
-
F
I
Q
-
D
G
Q
I
F
C
Q
G
R
L
D
F
Q
I
K
L
H
G
Y
R
M
E
L
E
E
I
E
F
H
V
R
Q
S
Q
Y
V
R
S
A
V
V
I
P
-
Y
------
Q
P
N
G
T
--
V
E
Y
L
I
A
A
I
V
P
E
E
---
H
-
E
F
E
K
E
F
Q
L
T
S
A
-
I
K
K
E
L
A
A
S
L
P
A
Y
M
I
P
R
K
F
I
Y
Q
D
H
I
Q
M
T
A
N
G
K
I
D
R
K
R
I
G
E
E
V
L
V
-------------------------------------------------------------------------------
31
HHSearch
98.38
100%
-109
- C2 -
3E7W
2
DLTA_BACSU
A:
[1-501]
---------
M
K
L
L
H
A
I
Q
T
H
A
E
T
Y
P
Q
T
D
A
F
R
S
Q
G
Q
S
L
T
Y
Q
E
L
W
E
Q
S
D
R
A
A
A
A
-
I
Q
K
R
I
S
G
-
E
K
K
S
P
I
L
V
Y
G
H
M
E
P
H
M
I
V
S
F
L
G
S
V
K
A
G
H
P
Y
I
P
V
D
L
S
I
P
S
E
R
I
A
K
I
I
-
E
S
S
G
A
E
L
L
I
H
------
A
A
G
L
S
I
--
D
A
V
G
---
Q
---
Q
I
-
Q
------
T
V
--
S
----
A
E
E
L
----
L
E
-
N
E
-----------
G
----
G
S
V
S
Q
D
Q
W
V
----
K
E
H
-----
E
T
F
Y
I
I
Y
T
S
G
S
T
G
N
P
K
G
V
Q
I
S
A
A
N
L
Q
S
F
T
D
-
W
I
C
A
D
--
F
-
P
V
S
G
G
K
I
F
L
N
Q
A
P
F
S
F
D
L
S
V
M
D
-
L
Y
P
C
L
Q
S
G
G
T
L
H
C
V
T
K
D
A
V
N
K
P
K
V
L
F
E
E
L
K
K
S
G
L
N
V
W
T
S
T
P
S
F
V
Q
M
C
L
M
D
P
G
F
S
Q
D
L
L
P
H
A
D
T
F
M
F
C
G
E
V
L
P
V
S
V
A
K
A
L
L
E
R
F
P
K
A
K
I
F
N
T
Y
G
P
T
E
A
T
V
A
V
T
S
V
E
I
T
N
D
V
I
S
R
S
E
S
L
P
V
G
F
A
K
P
D
M
N
I
F
I
M
D
E
E
G
Q
-----
P
L
-----
P
-
E
G
E
K
G
E
I
V
I
A
G
P
S
V
S
R
G
Y
L
G
E
P
E
L
T
E
K
A
F
F
S
H
----
E
----
G
Q
W
A
Y
R
T
G
D
-
A
G
-
F
I
Q
-
D
G
Q
I
F
C
Q
G
R
L
D
F
Q
I
K
L
H
G
Y
R
M
E
L
E
E
I
E
F
H
V
R
Q
S
Q
Y
V
R
S
A
V
V
I
P
-
Y
------
Q
P
N
G
T
--
V
E
Y
L
I
A
A
I
V
P
E
E
---
H
-
E
F
E
K
E
F
Q
L
T
S
A
-
I
K
K
E
L
A
A
S
L
P
A
Y
M
I
P
R
K
F
I
Y
Q
D
H
I
Q
M
T
A
N
G
K
I
D
R
K
R
I
G
E
E
V
---------------------------------------------------------------------------------
5
PsiBlast_PDB
78.47
56%
-35
- C2 -
3DHV
2
DLTA_BACCR
A:
[2-502]
----------
K
L
L
E
Q
I
E
K
W
A
A
E
T
P
D
Q
T
A
F
V
W
R
D
A
K
I
T
Y
K
Q
L
K
E
D
S
D
A
L
A
H
W
-
I
S
S
E
Y
P
--
D
D
R
S
P
I
M
V
Y
G
H
M
Q
P
E
M
I
I
N
F
L
G
C
V
K
A
G
H
A
Y
I
P
V
D
L
S
I
P
A
D
R
V
Q
R
I
A
-
E
N
S
G
A
K
L
L
L
S
------
A
T
A
V
T
V
--
T
D
L
--------
P
V
-
R
------
I
V
--
S
----
E
D
N
L
K
D
I
F
F
T
-
H
K
-----------
G
----
N
T
P
N
P
E
H
A
V
----
K
G
D
-----
E
N
F
Y
I
I
Y
T
S
-----
P
K
G
V
Q
I
T
Y
N
C
L
V
S
F
T
K
-
W
A
V
E
D
--
F
-
N
L
Q
T
G
Q
V
F
L
N
Q
A
P
F
S
F
D
L
S
V
M
D
-
I
Y
P
S
L
V
T
G
G
T
L
W
A
I
D
K
D
M
I
A
R
P
K
D
L
F
A
S
L
E
Q
S
D
I
Q
V
W
T
S
T
P
S
F
A
E
M
C
L
M
E
A
S
F
S
E
S
M
L
P
N
M
K
T
F
L
F
C
G
E
V
L
P
N
E
V
A
R
K
L
I
E
R
F
P
K
A
T
I
M
N
T
Y
G
P
T
E
A
T
V
A
V
T
G
I
H
V
T
E
E
V
L
D
Q
Y
K
S
L
P
V
G
Y
C
K
S
D
C
R
L
L
I
M
K
E
D
G
T
-----
I
A
-----
P
-
D
G
E
K
G
E
I
V
I
V
G
P
S
V
S
V
G
Y
L
G
S
P
E
L
T
E
K
A
F
T
M
I
----
D
----
G
E
R
A
Y
K
T
G
D
-
A
G
-
Y
V
E
-
N
G
L
L
F
Y
N
G
R
L
D
F
Q
I
K
L
H
G
Y
R
M
E
L
E
E
I
E
H
H
L
R
A
C
S
Y
V
E
G
A
V
I
V
P
-
I
------
K
K
G
E
K
--
Y
D
Y
L
L
A
V
V
V
P
G
E
---
H
-
S
F
E
K
E
F
K
L
T
S
A
-
I
K
K
E
L
N
E
R
L
P
N
Y
M
I
P
R
K
F
M
Y
Q
S
S
I
P
M
T
P
N
G
K
V
D
R
K
K
L
L
S
E
V
---------------------------------------------------------------------------------
3
PsiBlast_PDB
78.46
56%
-33
- C2 -
3FCC
1
DLTA_BACCR
A:
[1-502]
---------
M
K
L
L
E
Q
I
E
K
W
A
A
E
T
P
D
Q
T
A
F
V
W
R
D
A
K
I
T
Y
K
Q
L
K
E
D
S
D
A
L
A
H
W
-
I
S
S
E
Y
P
--
D
D
R
S
P
I
M
V
Y
G
H
M
Q
P
E
M
I
I
N
F
L
G
C
V
K
A
G
H
A
Y
I
P
V
D
L
S
I
P
A
D
R
V
Q
R
I
A
-
E
N
S
G
A
K
L
L
L
S
------
A
T
A
V
T
V
--
T
D
L
--------
P
V
-
R
------
I
V
--
S
----
E
D
N
L
K
D
I
F
F
T
-
H
K
-----------
G
----
N
T
P
N
P
E
H
A
V
----
K
G
D
-----
E
N
F
Y
I
I
Y
T
S
G
----
P
K
G
V
Q
I
T
Y
N
C
L
V
S
F
T
K
-
W
A
V
E
D
--
F
-
N
L
Q
T
G
Q
V
F
L
N
Q
A
P
F
S
F
D
L
S
V
M
D
-
I
Y
P
S
L
V
T
G
G
T
L
W
A
I
D
K
D
M
I
A
R
P
K
D
L
F
A
S
L
E
Q
S
D
I
Q
V
W
T
S
T
P
S
F
A
E
M
C
L
M
E
A
S
F
S
E
S
M
L
P
N
M
K
T
F
L
F
C
G
E
V
L
P
N
E
V
A
R
K
L
I
E
R
F
P
K
A
T
I
M
N
T
Y
G
P
T
E
A
T
V
A
V
T
G
I
H
V
T
E
E
V
L
D
Q
Y
K
S
L
P
V
G
Y
C
K
S
D
C
R
L
L
I
M
K
E
D
G
T
-----
I
A
-----
P
-
D
G
E
K
G
E
I
V
I
V
G
P
S
V
S
V
G
Y
L
G
S
P
E
L
T
E
K
A
F
T
M
I
----
D
----
G
E
R
A
Y
K
T
G
D
-
A
G
-
Y
V
E
-
N
G
L
L
F
Y
N
G
R
L
D
F
Q
I
K
L
H
G
Y
R
M
E
L
E
E
I
E
H
H
L
R
A
C
S
Y
V
E
G
A
V
I
V
P
-
I
------
K
K
G
E
K
--
Y
D
Y
L
L
A
V
V
V
P
G
E
---
H
-
S
F
E
K
E
F
K
L
T
S
A
-
I
K
K
E
L
N
E
R
L
P
N
Y
M
I
P
R
K
F
M
Y
Q
S
S
I
P
M
T
P
N
G
K
V
D
R
K
K
L
L
S
E
V
---------------------------------------------------------------------------------
4
PsiBlast_PDB
78.08
56%
-35
- C2 -
3FCE
1
DLTA_BACCR
A:
[1-502]
---------
M
K
L
L
E
Q
I
E
K
W
A
A
E
T
P
D
Q
T
A
F
V
W
R
D
A
K
I
T
Y
K
Q
L
K
E
D
S
D
A
L
A
H
W
-
I
S
S
E
Y
P
--
D
D
R
S
P
I
M
V
Y
G
H
M
Q
P
E
M
I
I
N
F
L
G
C
V
K
A
G
H
A
Y
I
P
V
D
L
S
I
P
A
D
R
V
Q
R
I
A
-
E
N
S
G
A
K
L
L
L
S
------
A
T
A
V
T
V
--
T
D
L
--------
P
V
-
R
------
I
V
--
S
----
E
D
N
L
K
D
I
F
F
T
-
H
K
-----------
G
----
N
T
P
N
P
E
H
A
V
----
K
G
D
-----
E
N
F
Y
I
I
Y
T
S
G
----
P
K
G
V
Q
I
T
Y
N
C
L
V
S
F
T
K
-
W
A
V
E
D
--
F
-
N
L
Q
T
G
Q
V
F
L
N
Q
A
P
F
S
F
D
L
S
V
M
D
-
I
Y
P
S
L
V
T
G
G
T
L
W
A
I
D
K
D
M
I
A
R
P
K
D
L
F
A
S
L
E
Q
S
D
I
Q
V
W
T
S
T
P
S
F
A
E
M
C
L
M
E
A
S
F
S
E
S
M
L
P
N
M
K
T
F
L
F
C
G
E
V
L
P
N
E
V
A
R
K
L
I
E
R
F
P
K
A
T
I
M
N
T
Y
G
P
T
E
A
T
V
A
V
T
G
I
H
V
T
E
E
V
L
D
Q
Y
K
S
L
P
V
G
Y
C
K
S
D
C
R
L
L
I
M
K
E
D
G
T
-----
I
A
-----
P
-
D
G
E
K
G
E
I
V
I
V
G
P
S
V
S
V
G
Y
L
G
S
P
E
L
T
E
K
A
F
T
M
I
----
D
----
G
E
R
A
Y
K
T
G
D
-
A
G
-
Y
V
E
-
N
G
L
L
F
Y
N
G
R
L
D
F
Q
I
K
L
H
G
Y
R
M
E
L
E
E
I
E
H
H
L
R
A
C
S
Y
V
E
G
A
V
I
V
P
-
I
------
K
K
G
E
K
--
Y
D
Y
L
L
A
V
V
V
P
G
E
---
H
-
S
F
E
K
E
F
K
L
T
S
A
-
I
K
K
E
L
N
E
R
L
P
N
Y
M
I
P
R
K
F
M
Y
Q
S
S
I
P
M
T
P
N
G
K
V
D
R
K
K
L
L
S
E
V
---------------------------------------------------------------------------------
6
PsiBlast_PDB
74.99
56%
-41
- C2 -
4PZP
-
DLTA_BACCR
A:
[2-501]
----------
K
L
L
E
Q
I
E
K
W
A
A
E
T
P
D
Q
T
A
F
V
W
R
D
A
K
I
T
Y
K
Q
L
K
E
D
S
D
A
L
A
H
W
-
I
S
S
E
Y
P
--
D
D
R
S
P
I
M
V
Y
G
H
M
Q
P
E
M
I
I
N
F
L
G
C
V
K
A
G
H
A
Y
I
P
V
D
L
S
I
P
A
D
R
V
Q
R
I
A
-
E
N
S
G
A
K
L
L
L
S
------
A
T
A
V
T
V
--
T
D
L
--------
P
V
-
R
------
I
V
--
S
----
E
D
N
L
K
D
I
F
F
T
-
H
K
-----------
G
----
N
T
P
N
P
E
H
A
V
----
K
G
D
-----
E
N
F
Y
I
I
Y
T
-------
K
G
V
Q
I
T
Y
N
C
L
V
S
F
T
K
-
W
A
V
E
D
--
F
-
N
L
Q
T
G
Q
V
F
L
N
Q
A
P
F
S
F
D
L
S
V
M
D
-
I
Y
P
S
L
V
T
G
G
T
L
W
A
I
D
K
D
M
I
A
R
P
K
D
L
F
A
S
L
E
Q
S
D
I
Q
V
W
T
S
T
P
S
F
A
E
M
C
L
M
E
A
S
F
S
E
S
M
L
P
N
M
K
T
F
L
F
C
G
E
V
L
P
N
E
V
A
R
K
L
I
E
R
F
P
K
A
T
I
M
N
T
Y
G
P
T
E
A
T
V
A
V
T
G
I
H
V
T
E
E
V
L
D
Q
Y
K
S
L
P
V
G
Y
C
K
S
D
C
R
L
L
I
M
K
E
D
G
T
-----
I
A
-----
P
-
D
G
E
K
G
E
I
V
I
V
G
P
S
V
S
V
G
Y
L
G
S
-----
K
A
F
T
M
I
----
D
----
G
E
R
A
Y
K
T
G
D
-
A
G
-
Y
V
E
-
N
G
L
L
F
Y
N
G
-----------------
I
E
H
H
L
R
A
C
S
Y
V
E
G
A
V
I
V
P
-
I
----------------
L
L
A
V
V
V
P
G
E
---
H
-
S
F
E
K
E
F
K
L
T
S
A
-
I
K
K
E
L
N
E
R
L
P
N
Y
M
I
P
R
K
F
M
Y
Q
S
S
I
P
M
T
P
N
G
K
V
D
R
K
K
L
L
S
E
----------------------------------------------------------------------------------
39
HHSearch
71.38
56%
-13
- C2 -
4PZP
-
DLTA_BACCR
A:
[3-501]
-----------
L
L
E
Q
I
E
K
W
A
A
E
T
P
D
Q
T
A
F
V
W
R
D
A
K
I
T
Y
K
Q
L
K
E
D
S
D
A
L
A
H
W
-
I
S
S
E
--
Y
P
D
D
R
S
P
I
M
V
Y
G
H
M
Q
P
E
M
I
I
N
F
L
G
C
V
K
A
G
H
A
Y
I
P
V
D
L
S
I
P
A
D
R
V
Q
R
I
A
-
E
N
S
G
A
K
L
L
L
S
------
A
T
A
V
T
V
--
T
D
L
P
---
V
---
R
I
V
S
------
E
D
--
N
----
L
K
D
I
----
F
F
T
H
K
-----------
G
----
N
T
P
N
P
E
H
A
V
----
K
G
D
-----
E
N
F
Y
I
I
Y
T
-------
K
G
V
Q
I
T
Y
N
C
L
V
S
F
T
K
-
W
A
V
E
D
--
F
-
N
L
Q
T
G
Q
V
F
L
N
Q
A
P
F
S
F
D
L
S
V
M
D
-
I
Y
P
S
L
V
T
G
G
T
L
W
A
I
D
K
D
M
I
A
R
P
K
D
L
F
A
S
L
E
Q
S
D
I
Q
V
W
T
S
T
P
S
F
A
E
M
C
L
M
E
A
S
F
S
E
S
M
L
P
N
M
K
T
F
L
F
C
G
E
V
L
P
N
E
V
A
R
K
L
I
E
R
F
P
K
A
T
I
M
N
T
Y
G
P
T
E
A
T
V
A
V
T
G
I
H
V
T
E
E
V
L
D
Q
Y
K
S
L
P
V
G
Y
C
K
S
D
C
R
L
L
I
M
K
E
D
G
T
-----
I
A
-----
P
-
D
G
E
K
G
E
I
V
I
V
G
P
S
V
S
V
G
Y
L
G
S
-----
K
A
F
T
M
I
----
D
----
G
E
R
A
Y
K
T
G
D
-
A
G
-
Y
V
E
-
N
G
L
L
F
Y
N
G
-----------------
I
E
H
H
L
R
A
C
S
Y
V
E
G
A
V
I
V
P
-
I
----------------
L
L
A
V
V
V
P
G
E
---
H
-
S
F
E
K
E
F
K
L
T
S
A
-
I
K
K
E
L
N
E
R
L
P
N
Y
M
I
P
R
K
F
M
Y
Q
S
S
I
P
M
T
P
N
G
K
V
D
R
K
K
L
L
S
E
----------------------------------------------------------------------------------
22
PsiBlast_CBE
69.18
42%
-12
- C2 -
3LGX
1
DLTA_STRP1
C:
[6-510]
-----------
M
I
D
S
I
E
Q
F
A
Q
T
Q
A
D
F
P
V
Y
D
C
L
G
E
R
R
T
Y
G
Q
L
K
R
D
S
D
S
I
A
A
F
-
I
D
S
-
L
A
L
-
L
A
K
S
P
V
L
V
F
G
A
Q
T
Y
D
M
L
A
T
F
V
A
L
T
K
S
G
H
A
Y
I
P
V
D
V
H
S
A
P
E
R
I
L
A
I
I
-
E
I
A
K
P
S
L
I
I
-----------
A
I
--
E
E
F
P
---
L
---
T
I
-
E
------
G
I
--
S
----
L
V
S
L
----
S
E
-
I
E
-----------
S
----
A
K
L
A
E
M
P
Y
E
----
R
T
H
SVKGD
D
N
Y
Y
I
I
F
T
S
--
T
G
Q
P
K
G
V
Q
I
S
H
D
N
L
L
S
F
T
N
-
W
M
I
E
D
AA
F
-
D
V
P
K
Q
P
Q
M
L
A
Q
P
P
Y
S
F
D
L
S
V
M
Y
-
W
A
P
T
L
A
L
G
G
T
L
F
A
L
P
K
E
L
V
A
D
F
K
Q
L
F
T
T
I
A
Q
L
P
V
G
I
W
T
S
T
P
S
F
A
D
M
A
M
L
S
D
D
F
C
Q
A
K
M
P
A
L
T
H
F
Y
F
D
G
E
E
L
T
V
S
T
A
R
K
L
F
E
R
F
P
S
A
K
I
I
N
A
Y
G
P
T
E
A
T
V
A
L
S
A
I
E
I
T
R
E
M
V
D
N
Y
T
R
L
P
I
G
Y
P
K
P
D
S
P
T
Y
I
I
D
E
D
G
K
-----
E
L
-----
S
-
S
G
E
Q
G
E
I
I
V
T
G
P
A
V
S
K
G
Y
L
N
N
P
E
K
T
A
E
A
F
F
T
F
----
K
----
G
Q
P
A
Y
H
T
G
D
-
I
G
S
L
T
E
-
D
N
I
L
L
Y
G
G
R
L
D
F
Q
I
K
Y
A
G
Y
R
I
E
L
E
D
V
S
Q
Q
L
N
Q
S
P
M
V
A
S
A
V
A
V
P
R
Y
------
N
K
E
H
K
--
V
Q
N
L
L
A
Y
I
V
V
K
D
GVK
E
-
R
F
D
R
E
L
E
L
T
K
A
-
I
K
A
S
V
K
D
H
M
M
S
Y
M
M
P
S
K
F
L
Y
R
D
S
L
P
L
T
P
N
G
K
I
D
I
K
T
L
I
N
E
V
---------------------------------------------------------------------------------
8
PsiBlast_PDB
68.90
42%
-15
- C2 -
3LGX
1
DLTA_STRP1
A:
[6-510]
-----------
M
I
D
S
I
E
Q
F
A
Q
T
Q
A
D
F
P
V
Y
D
C
L
G
E
R
R
T
Y
G
Q
L
K
R
D
S
D
S
I
A
A
F
-
I
D
S
-
L
A
L
-
L
A
K
S
P
V
L
V
F
G
A
Q
T
Y
D
M
L
A
T
F
V
A
L
T
K
S
G
H
A
Y
I
P
V
D
V
H
S
A
P
E
R
I
L
A
I
I
-
E
I
A
K
P
S
L
I
I
-----------
A
I
--
E
E
F
P
---
L
---
T
I
-
E
------
G
I
--
S
----
L
V
S
L
----
S
E
-
I
E
-----------
S
----
A
K
L
A
E
M
P
Y
E
----
R
T
H
SVKGD
D
N
Y
Y
I
I
F
T
S
--
T
G
Q
P
K
G
V
Q
I
S
H
D
N
L
L
S
F
T
N
-
W
M
I
E
D
AA
F
-
D
V
P
K
Q
P
Q
M
L
A
Q
P
P
Y
S
F
D
L
S
V
M
Y
-
W
A
P
T
L
A
L
G
G
T
L
F
A
L
P
K
E
L
V
A
D
F
K
Q
L
F
T
T
I
A
Q
L
P
V
G
I
W
T
S
T
P
S
F
A
D
M
A
M
L
S
D
D
F
C
Q
A
K
M
P
A
L
T
H
F
Y
F
D
G
E
E
L
T
V
S
T
A
R
K
L
F
E
R
F
P
S
A
K
I
I
N
A
Y
G
P
T
E
A
T
V
A
L
S
A
I
E
I
T
R
E
M
V
D
N
Y
T
R
L
P
I
G
Y
P
K
P
D
S
P
T
Y
I
I
D
E
D
G
K
-----
E
L
-----
S
-
S
G
E
Q
G
E
I
I
V
T
G
P
A
V
S
K
G
Y
L
N
N
P
E
K
T
A
E
A
F
F
T
F
----
K
----
G
Q
P
A
Y
H
T
G
D
-
I
G
S
L
T
E
-
D
N
I
L
L
Y
G
G
R
L
D
F
Q
I
K
Y
A
G
Y
R
I
E
L
E
D
V
S
Q
Q
L
N
Q
S
P
M
V
A
S
A
V
A
V
P
R
Y
------
N
K
E
H
K
--
V
Q
N
L
L
A
Y
I
V
V
K
D
G
V
K
E
-
R
F
D
R
E
L
E
L
T
K
A
-
I
K
A
S
V
K
D
H
M
M
S
Y
M
M
P
S
K
F
L
Y
R
D
S
L
P
L
T
P
N
G
K
I
D
I
K
T
L
I
N
E
V
---------------------------------------------------------------------------------
23
PsiBlast_CBE
68.21
42%
-13
- C2 -
3LGX
1
DLTA_STRP1
B:
[6-510]
-----------
M
I
D
S
I
E
Q
F
A
Q
T
Q
A
D
F
P
V
Y
D
C
L
G
E
R
R
T
Y
G
Q
L
K
R
D
S
D
S
I
A
A
F
-
I
D
S
-
L
A
L
-
L
A
K
S
P
V
L
V
F
G
A
Q
T
Y
D
M
L
A
T
F
V
A
L
T
K
S
G
H
A
Y
I
P
V
D
V
H
S
A
P
E
R
I
L
A
I
I
-
E
I
A
K
P
S
L
I
I
-----------
A
I
--
E
E
F
P
---
L
---
T
I
-
E
------
G
I
--
S
----
L
V
S
L
----
S
E
-
I
E
-----------
S
----
A
K
L
A
E
M
P
Y
E
----
R
T
H
SVKGD
D
N
Y
Y
I
I
F
T
S
---
G
Q
P
K
G
V
Q
I
S
H
D
N
L
L
S
F
T
N
-
W
M
I
E
D
AA
F
-
D
V
P
K
Q
P
Q
M
L
A
Q
P
P
Y
S
F
D
L
S
V
M
Y
-
W
A
P
T
L
A
L
G
G
T
L
F
A
L
P
K
E
L
V
A
D
F
K
Q
L
F
T
T
I
A
Q
L
P
V
G
I
W
T
S
T
P
S
F
A
D
M
A
M
L
S
D
D
F
C
Q
A
K
M
P
A
L
T
H
F
Y
F
D
G
E
E
L
T
V
S
T
A
R
K
L
F
E
R
F
P
S
A
K
I
I
N
A
Y
G
P
T
E
A
T
V
A
L
S
A
I
E
I
T
R
E
M
V
D
N
Y
T
R
L
P
I
G
Y
P
K
P
D
S
P
T
Y
I
I
D
E
D
G
K
-----
E
L
-----
S
-
S
G
E
Q
G
E
I
I
V
T
G
P
A
V
S
K
G
Y
L
N
N
P
E
K
T
A
E
A
F
F
T
F
----
K
----
G
Q
P
A
Y
H
T
G
D
-
I
G
S
L
T
E
-
D
N
I
L
L
Y
G
G
R
L
D
F
Q
I
K
Y
A
G
Y
R
I
E
L
E
D
V
S
Q
Q
L
N
Q
S
P
M
V
A
S
A
V
A
V
P
R
Y
------
N
K
E
H
K
--
V
Q
N
L
L
A
Y
I
V
V
K
D
G
V
K
E
-
R
F
D
R
E
L
E
L
T
K
A
-
I
K
A
S
V
K
D
H
M
M
S
Y
M
M
P
S
K
F
L
Y
R
D
S
L
P
L
T
P
N
G
K
I
D
I
K
T
L
I
N
E
V
---------------------------------------------------------------------------------
7
PsiBlast_PDB
68.16
42%
-18
- C2 -
3L8C
-
DLTA_STRP6
A:
[1-505]
-----------
M
I
D
S
I
E
Q
F
A
Q
T
Q
A
D
F
P
V
Y
D
C
L
G
E
R
R
T
Y
G
Q
L
K
R
D
S
D
S
I
A
A
F
-
I
D
S
-
L
A
L
-
L
A
K
S
P
V
L
V
F
G
A
Q
T
Y
D
M
L
A
T
F
V
A
L
T
K
S
G
H
A
Y
I
P
V
D
V
H
S
A
P
E
R
I
L
A
I
I
-
E
I
A
K
P
S
L
I
I
-----------
A
I
--
E
E
F
P
---
L
---
T
I
-
E
------
G
I
--
S
----
L
V
S
L
----
S
E
-
I
E
-----------
S
----
A
K
L
A
E
M
P
Y
E
----
R
T
H
SVKGD
D
N
Y
Y
I
I
F
T
S
---
G
Q
P
K
G
V
Q
I
S
H
D
N
L
L
S
F
T
N
-
W
M
I
E
D
AA
F
-
D
V
P
K
Q
P
Q
M
L
A
Q
P
P
Y
S
F
D
L
S
V
M
Y
-
W
A
P
T
L
A
L
G
G
T
L
F
A
L
P
K
E
L
V
A
D
F
K
Q
L
F
T
T
I
A
Q
L
P
V
G
I
W
T
S
T
P
S
F
A
D
M
A
M
L
S
D
D
F
C
Q
A
K
M
P
A
L
T
H
F
Y
F
D
G
E
E
L
T
V
S
T
A
R
K
L
F
E
R
F
P
S
A
K
I
I
N
A
Y
G
P
T
E
A
T
V
A
L
S
A
I
E
I
T
R
E
M
V
D
N
Y
T
R
L
P
I
G
Y
P
K
P
D
S
P
T
Y
I
I
D
E
D
G
K
-----
E
L
-----
S
-
S
G
E
Q
G
E
I
I
V
T
G
P
A
V
S
K
G
Y
L
N
N
P
E
K
T
A
E
A
F
F
T
F
----
K
----
G
Q
P
A
Y
H
T
G
D
-
I
G
S
L
T
E
-
D
N
I
L
L
Y
G
G
R
L
D
F
Q
I
K
-----
I
E
L
E
D
V
S
Q
Q
L
N
Q
S
P
M
V
A
S
A
V
A
V
P
R
Y
------
N
K
E
H
K
-----
L
L
A
Y
I
V
V
K
D
G
V
K
E
-
R
F
D
R
E
L
E
L
T
K
A
-
I
K
A
S
V
K
D
H
M
M
S
Y
M
M
P
S
K
F
L
Y
R
D
S
L
P
L
T
P
N
G
K
I
D
I
K
T
L
I
N
E
V
---------------------------------------------------------------------------------
21
PsiBlast_CBE
67.69
42%
-15
- C2 -
3LGX
1
DLTA_STRP1
D:
[6-510]
-----------
M
I
D
S
I
E
Q
F
A
Q
T
Q
A
D
F
P
V
Y
D
C
L
G
E
R
R
T
Y
G
Q
L
K
R
D
S
D
S
I
A
A
F
-
I
D
S
-
L
A
L
-
L
A
K
S
P
V
L
V
F
G
A
Q
T
Y
D
M
L
A
T
F
V
A
L
T
K
S
G
H
A
Y
I
P
V
D
V
H
S
A
P
E
R
I
L
A
I
I
-
E
I
A
K
P
S
L
I
I
-----------
A
I
--
E
E
F
P
---
L
---
T
I
-
E
------
G
I
--
S
----
L
V
S
L
----
S
E
-
I
E
-----------
S
----
A
K
L
A
E
M
P
Y
E
----
R
T
H
SVKGD
D
N
Y
Y
I
I
F
T
S
--
T
G
Q
P
K
G
V
Q
I
S
H
D
N
L
L
S
F
T
N
-
W
M
I
E
D
AA
F
-
D
V
P
K
Q
P
Q
M
L
A
Q
P
P
Y
S
F
D
L
S
V
M
Y
-
W
A
P
T
L
A
L
G
G
T
L
F
A
L
P
K
E
L
V
A
D
F
K
Q
L
F
T
T
I
A
Q
L
P
V
G
I
W
T
S
T
P
S
F
A
D
M
A
M
L
S
D
D
F
C
Q
A
K
M
P
A
L
T
H
F
Y
F
D
G
E
E
L
T
V
S
T
A
R
K
L
F
E
R
F
P
S
A
K
I
I
N
A
Y
G
P
T
E
A
T
V
A
L
S
A
I
E
I
T
R
E
M
V
D
N
Y
T
R
L
P
I
G
Y
P
K
P
D
S
P
T
Y
I
I
D
E
D
G
K
-----
E
L
-----
S
-
S
G
E
Q
G
E
I
I
V
T
G
P
A
V
S
K
G
Y
L
N
N
P
E
K
T
A
E
A
F
F
T
F
----
K
----
G
Q
P
A
Y
H
T
G
D
-
I
G
S
L
T
E
-
D
N
I
L
L
Y
G
G
R
L
D
F
Q
I
K
Y
A
G
Y
R
I
E
L
E
D
V
S
Q
Q
L
N
Q
S
P
M
V
A
S
A
V
A
V
P
R
Y
------
N
K
E
H
K
--
V
Q
N
L
L
A
Y
I
V
V
K
D
GVK
E
-
R
F
D
R
E
L
E
L
T
K
A
-
I
K
A
S
V
K
D
H
M
M
S
Y
M
M
P
S
K
F
L
Y
R
D
S
L
P
L
T
P
N
G
K
I
D
I
K
T
L
I
N
E
V
---------------------------------------------------------------------------------
37
HHSearch
60.63
29%
-28
- C2 -
4ZXH
-
?
A:
[485-963]
-------------
A
M
I
L
K
Q
I
D
E
R
G
D
N
H
A
L
T
S
--
H
T
V
S
Y
R
E
L
G
Q
H
I
A
G
I
A
E
Y
-
L
R
A
H
--
G
I
T
Q
G
D
R
V
G
L
M
L
D
R
T
A
L
L
P
A
A
I
L
G
I
W
A
A
G
A
A
Y
V
P
L
D
P
N
F
P
T
E
R
L
Q
N
I
I
-
E
D
A
E
P
K
V
I
L
T
------
Q
T
E
L
M
D
--
G
-
L
N
---
V
---
S
V
-
P
------
R
L
--
D
----
I
N
Q
A
----
G
---
V
-----------
V
----
A
L
E
Q
V
R
E
T
L
----
A
F
G
-----
D
I
A
Y
V
M
Y
T
S
----
K
P
K
G
V
R
I
G
H
P
S
I
I
N
F
L
L
-
S
M
N
D
R
--
L
-
Q
V
T
T
E
T
Q
L
L
A
I
T
T
Y
A
F
D
I
S
I
L
E
-
L
L
I
P
L
M
Y
G
G
V
V
H
V
C
P
R
E
V
S
Q
D
G
I
Q
L
V
D
Y
L
N
A
K
S
I
N
V
L
Q
A
T
P
A
T
W
K
M
L
L
D
S
E
W
----
S
G
N
A
G
L
T
A
L
C
G
G
E
A
L
D
T
I
L
A
E
K
L
L
G
K
V
--
G
C
L
W
N
V
Y
G
P
T
E
T
T
V
W
S
S
A
A
R
I
T
-----
D
A
K
Y
I
D
L
G
E
P
L
A
N
T
Q
L
Y
V
L
D
E
Q
Q
R
-----
L
V
-----
P
-
P
G
V
M
G
E
L
W
I
G
G
D
G
L
A
V
D
Y
W
Q
R
P
E
L
T
D
A
Q
F
R
T
L
----
P
SLPN
A
G
R
L
Y
R
T
G
D
-
K
V
-
C
L
R
T
D
G
R
L
T
H
H
G
R
L
D
F
Q
V
K
I
R
G
F
R
I
E
L
G
E
I
E
N
V
L
K
Q
I
D
G
I
T
D
A
V
V
L
V
-
K
------
T
T
G
D
N
--
D
Q
K
L
V
A
Y
V
T
G
Q
E
---
L
--------
D
I
A
G
-
L
K
K
N
L
Q
I
H
L
P
A
Y
M
V
P
S
A
F
I
R
L
D
E
F
P
M
T
A
N
K
K
L
D
R
K
A
F
P
E
P
----------------------------------------------------------------------------------
38
HHSearch
60.55
27%
-31
- C2 -
4OXI
1
?
A:
[59-567]
------------------
A
I
Q
A
N
R
H
A
P
A
L
W
V
K
Q
K
T
Y
T
Y
Q
E
M
T
D
M
A
L
S
L
S
D
Y
-
W
H
L
Q
--
G
---
V
Q
R
V
A
I
L
S
V
R
D
L
A
A
Y
S
A
I
W
A
S
Y
L
G
G
M
T
Y
I
P
L
N
A
R
A
T
T
E
Q
I
Q
E
T
L
-
I
A
T
Q
C
D
S
I
M
V
------
D
A
Q
Q
L
S
R
L
S
S
L
L
E
--
T
CI
D
R
L
-
H
I
Y
A
---
L
P
DV
D
----
V
E
P
L
----
R
Q
-
Q
Y
PQ
H
T
F
H
T
V
Q
I
T
E
Q
D
VE
L
L
V
V
K
Y
-
L
D
----
N
E
H
-----
E
Y
A
Y
I
M
Q
T
S
G
S
T
G
K
P
K
R
I
A
V
S
Y
S
N
L
H
C
Y
I
S
-
Q
I
D
K
L
--
F
-
P
L
N
A
Q
D
R
V
G
Q
Y
S
D
L
T
F
D
L
S
V
H
D
-
I
F
Y
S
L
I
S
G
A
C
L
Y
V
V
P
E
L
---
A
K
L
S
P
A
E
F
I
H
H
H
Q
L
T
V
W
L
S
V
P
T
V
I
E
L
A
L
Q
R
Q
T
L
T
P
H
S
L
P
S
L
R
L
S
F
F
C
G
Q
A
L
L
H
D
L
A
E
Q
W
Q
Q
A
T
-
Q
Q
P
V
I
N
L
Y
G
P
T
E
C
T
I
A
V
T
Y
H
R
F
V
A
H
--
S
G
M
A
S
V
P
I
G
R
A
F
E
E
E
C
L
A
I
I
N
E
Q
G
E
L
M
R
FE
S
A
-----
P
-
E
G
Y
R
G
E
L
L
L
S
G
K
Q
L
V
K
G
Y
L
N
D
P
L
N
T
Q
S
A
F
F
Q
H
----
E
----
G
R
L
W
Y
R
S
G
D
-
I
V
-
T
K
S
-
N
G
V
L
I
H
L
G
R
R
D
H
Q
V
K
I
A
G
Q
R
V
E
L
E
E
I
E
T
V
V
R
R
V
T
Q
A
H
S
V
A
I
V
P
-
W
------
P
L
S
E
S
GY
A
S
G
T
V
A
F
V
D
T
H
T
---
Q
-------
W
Q
P
D
L
-
W
L
S
Q
C
K
Q
Q
L
N
P
T
F
V
P
K
R
W
Y
A
I
E
Q
L
P
R
----
K
T
D
I
K
A
L
Q
Q
Q
L
---------------------------------------------------------------------------------
48
Fugue
60.02
23%
-9
- C2 -
4DG9
1
?
A:
[18-604]
NSLLDLYAH
P
T
V
V
A
R
F
S
E
M
A
A
L
H
P
H
R
E
A
I
R
D
R
F
G
S
V
D
Y
R
Q
L
L
D
S
A
E
Q
L
S
D
Y
-
L
L
E
H
-
Y
P
-
Q
P
G
V
C
L
G
V
Y
G
E
Y
S
R
E
S
I
T
C
L
L
A
I
L
L
S
G
H
H
Y
L
Y
I
D
L
K
Q
P
A
A
W
N
A
E
L
C
-
R
Q
V
D
C
R
L
I
L
D
------
C
S
T
T
P
----
T
P
A
---
N
---
G
L
-
P
------
C
V
--
P
----
V
R
H
L
----
P
A
-
A
P
-----------
A
----
S
V
A
R
P
C
F
------
A
A
D
-----
Q
I
A
Y
I
N
F
S
S
G
T
T
G
R
P
K
A
I
A
C
T
H
A
G
I
T
R
L
C
L
-
G
-
Q
S
F
--
L
-
A
F
A
P
Q
M
R
F
L
V
N
S
P
L
S
F
D
A
A
T
L
E
-
I
W
G
A
L
L
N
G
G
C
C
V
L
N
D
L
G
P
L
D
-
P
G
V
L
R
Q
L
I
G
E
R
G
A
D
S
A
W
L
T
A
S
L
F
N
T
L
V
D
L
---
D
P
D
C
L
G
G
L
R
Q
L
L
T
G
G
D
I
L
S
V
P
H
V
R
R
A
L
L
R
H
P
R
L
H
L
V
N
G
Y
G
P
T
E
N
T
T
F
T
C
C
H
V
V
-
T
D
D
D
L
E
E
D
D
I
P
I
G
K
A
I
A
G
T
A
V
L
L
L
D
E
H
G
Q
-----
E
I
-----
A
E
P
D
R
A
G
E
I
V
A
F
G
A
G
L
A
Q
G
Y
R
N
D
A
A
R
T
R
A
S
F
V
E
L
P
Y
RG
R
----
L
L
R
A
Y
R
T
G
D
R
A
R
-
Y
D
E
-
Q
G
R
L
R
F
I
G
R
G
D
G
Q
V
K
L
N
G
Y
R
L
D
L
P
A
L
E
Q
R
F
R
R
Q
P
G
I
L
D
C
A
L
L
V
-
R
------
E
R
N
G
V
--
K
Q
L
L
C
A
W
T
G
K
A
D
---------------
A
-
S
P
Q
A
L
L
R
Q
L
P
T
W
Q
R
P
H
A
C
V
R
V
E
A
L
P
L
T
A
H
G
K
L
D
R
A
A
L
L
R
R
L
E
L
DP
D
Q
R
G
C
A
Q
L
W
S
E
L
L
G
C
E
V
G
ADFFLCGGN
S
L
L
A
L
Q
L
V
A
L
C
Q
S
A
GAGANLGLADLQANSR
L
D
Q
F
S
R
L
L
R
S
H
GLAPERLLE
9
PsiBlast_PDB
59.01
30%
-9
- C2 -
2VSQ
2
A:
[478-969]
-----------------------
P
D
A
P
A
L
T
Y
S
G
Q
T
L
S
Y
R
E
L
D
E
E
A
N
R
I
A
R
R
-
L
Q
K
H
G
A
G
--
K
G
S
V
V
A
L
Y
T
K
R
S
L
E
L
V
I
G
I
L
G
V
L
K
A
G
A
A
Y
L
P
V
D
P
K
L
P
E
D
R
I
S
Y
M
L
A
D
S
A
A
A
C
L
L
T
H
QEMKEQ
A
A
E
L
P
Y
--
T
G
T
------------------
T
L
--
F
----
I
D
D
Q
----
T
R
-
F
E
-----------
E
----
Q
A
S
D
P
A
T
A
I
----
D
P
N
-----
D
P
A
Y
I
M
Y
T
S
G
T
T
G
K
P
K
G
N
I
T
T
H
A
N
I
Q
G
L
V
K
-
H
V
--
D
--
Y
M
A
F
S
D
Q
D
T
F
L
S
V
S
N
Y
A
F
D
A
F
T
F
D
-
F
Y
A
S
M
L
N
A
A
R
L
I
I
A
D
E
H
T
L
L
D
T
E
R
L
T
D
L
I
L
Q
E
N
V
N
V
M
F
A
T
T
A
L
F
N
L
-
L
T
D
A
G
--
E
D
W
M
K
G
L
R
C
I
L
F
G
G
E
R
A
S
V
P
H
V
R
K
A
L
R
I
M
G
P
G
K
L
I
N
C
Y
G
P
T
E
G
T
V
F
A
T
A
-
H
V
V
H
D
L
P
D
S
I
S
S
L
P
I
G
K
P
I
S
N
A
S
V
Y
I
L
N
E
Q
S
Q
-----
L
Q
-----
P
-
F
G
A
V
G
E
L
C
I
S
G
M
G
V
S
K
G
Y
V
N
R
A
D
L
T
K
E
K
F
I
E
N
PFK-
P
----
G
E
T
L
Y
R
T
G
D
L
A
R
-
W
L
P
-
D
G
T
I
E
Y
A
G
R
I
D
D
Q
V
K
I
R
G
H
R
I
E
L
E
E
I
E
K
Q
L
Q
E
Y
P
G
V
K
D
A
V
V
V
A
-
D
------
R
H
E
S
G
--
D
A
S
I
N
A
Y
L
V
-----------
N
R
T
Q
L
S
A
E
D
V
K
A
H
L
K
K
Q
L
P
A
Y
M
V
P
Q
T
F
T
F
L
D
E
L
P
L
T
T
N
G
K
V
N
K
R
---------------------------------------------------------------------------------------
47
HHSearch
58.43
24%
-32
- C2 -
4DG8
3
?
A:
[29-511]
-----------
V
V
A
R
F
S
E
M
A
A
L
H
P
H
R
E
A
I
R
D
R
F
G
S
V
D
Y
R
Q
L
L
D
S
A
E
Q
L
S
D
Y
-
L
L
E
H
--
Y
P
Q
P
G
V
C
L
G
V
Y
G
E
Y
S
R
E
S
I
T
C
L
L
A
I
L
L
S
G
H
H
Y
L
Y
I
D
L
K
Q
P
A
A
W
N
A
E
L
C
-
R
Q
V
D
C
R
L
I
L
D
------
C
S
T
T
P
T
--
P
A
-----
N
---
G
L
-
P
------
C
V
--
P
----
V
R
H
L
----
P
A
--------------
A
----
P
A
S
V
A
R
P
C
F
----
A
A
D
-----
Q
I
A
Y
I
N
F
S
S
G
T
T
G
R
P
K
A
I
A
C
T
H
A
G
I
T
R
L
C
L
-
G
Q
-
S
F
--
L
-
A
F
A
P
Q
M
R
F
L
V
N
S
P
L
S
F
D
A
A
T
L
E
-
I
W
G
A
L
L
N
G
G
C
C
V
L
N
D
L
G
-
P
L
D
P
G
V
L
R
Q
L
I
G
E
R
G
A
D
S
A
W
L
T
A
S
L
F
N
T
L
V
D
L
D
---
P
D
C
L
G
G
L
R
Q
L
L
T
G
G
D
I
L
S
V
P
H
V
R
R
A
L
L
R
H
P
R
L
H
L
V
N
G
Y
G
P
T
E
N
T
T
F
T
C
C
H
V
V
T
D
D
-
D
L
E
E
D
D
I
P
I
G
K
A
I
A
G
T
A
V
L
L
L
D
E
H
G
Q
-----
E
I
A----
E
-
P
D
R
A
G
E
I
V
A
F
G
A
G
L
A
Q
G
Y
R
N
D
A
A
R
T
R
A
S
F
V
E
L
----
P
Y
RG
R
L
L
R
A
Y
R
T
G
D
-
R
A
-
R
Y
D
E
Q
G
R
L
R
F
I
G
R
G
D
G
Q
V
K
L
N
G
Y
R
L
D
L
P
A
L
E
Q
R
F
R
R
Q
P
G
I
L
D
C
A
L
L
V
-
R
------
E
R
N
G
V
--
K
-
Q
L
L
C
A
W
T
G
K
A
--------------
D
A
-
S
P
Q
A
L
L
R
Q
L
P
T
W
Q
R
P
H
A
C
V
R
V
E
A
L
P
L
T
----
L
D
R
A
A
L
L
R
R
L
---------------------------------------------------------------------------------
46
HHSearch
58.30
18%
-14
- C2 -
4WV3
1
?
A:
[12-516]
-----------
A
V
D
I
L
E
R
N
L
P
V
R
A
N
K
T
A
L
F
T
P
D
R
E
M
T
F
R
Q
V
S
N
E
A
N
Q
V
G
N
A
-
L
K
G
L
--
G
V
R
F
G
E
C
V
G
L
L
T
L
D
S
A
E
W
V
T
S
F
F
G
I
V
K
L
G
A
I
A
V
G
I
N
T
L
L
K
P
P
E
Y
E
Y
I
L
-
R
D
C
R
A
R
V
L
I
V
------
H
Q
E
F
L
P
L
I
E
S
I
R
---
G
---
N
L
-
P
MLE
H
I
V
V
I
--
G
GYLS
F
N
D
W
----
I
R
--
P
-----------
Q
----
P
T
T
L
E
A
A
Q
S
----
H
R
E
-----
D
I
C
S
L
N
Y
S
S
G
-
T
G
G
P
K
G
I
P
H
A
H
K
D
Y
P
L
T
A
Q
L
W
G
V
N
V
--
L
-
G
L
R
E
S
D
R
T
F
A
L
A
K
L
F
F
T
F
G
T
G
G
N
L
I
F
P
W
Y
V
G
A
S
C
V
L
F
P
G
A
A
-
R
V
A
S
N
V
L
S
T
I
S
R
F
K
P
T
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F
Y
N
A
P
T
G
Y
A
A
A
L
A
L
K
D
F
S
Q
H
D
L
S
S
L
R
L
C
V
S
A
S
E
A
L
P
A
A
L
W
Y
A
W
K
E
A
T
-
G
V
D
I
I
D
G
I
G
C
T
E
N
F
H
I
F
I
S
N
R
P
G
-----
D
I
R
P
G
S
S
G
K
P
V
E
G
Y
E
L
K
L
V
D
D
E
G
K
-----
T
V
-----
P
-
A
G
E
I
G
N
V
L
L
R
S
E
T
A
A
L
S
Y
W
H
N
F
E
K
S
R
Q
T
F
------------
Q
G
E
W
L
A
T
G
D
-
K
Y
-
F
V
D
A
D
G
Y
Y
W
H
A
G
R
S
D
D
M
L
K
V
G
G
I
W
V
S
P
V
E
V
E
S
T
L
I
Q
H
P
A
V
Q
E
C
A
V
I
G
-
C
------
P
D
Q
S
R
--
L
I
K
P
K
A
F
I
I
L
K
P
---
E
-
Q
I
P
-
S
E
A
L
I
R
Q
-
I
T
D
H
C
T
E
K
M
A
A
Y
K
R
P
R
W
I
E
F
V
T
E
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
R
S
A
A
---------------------------------------------------------------------------------
34
HHSearch
57.70
29%
3
- C2 -
2VSQ
2
A:
[466-974]
-----------
L
T
Y
W
F
K
E
A
V
N
A
N
P
D
A
P
A
L
T
Y
S
G
Q
T
L
S
Y
R
E
L
D
E
E
A
N
R
I
A
R
R
-
L
Q
K
H
--
G
A
G
K
G
S
V
V
A
L
Y
T
K
R
S
L
E
L
V
I
G
I
L
G
V
L
K
A
G
A
A
Y
L
P
V
D
P
K
L
P
E
D
R
I
S
Y
M
L
-
A
D
S
A
A
A
C
L
L
T
------
H
Q
E
M
K
E
QA
A
E
L
P
YT
G
T
---
T
L
-
F
------
I
D
--
D
----
Q
T
R
-----
F
---
E
-----------
E
----
Q
A
S
D
P
A
T
A
I
----
D
P
N
-----
D
P
A
Y
I
M
Y
T
S
G
T
T
G
K
P
K
G
N
I
T
T
H
A
N
I
Q
G
L
V
K
-
H
V
-
D
Y
--
M
-
A
F
S
D
Q
D
T
F
L
S
V
S
N
Y
A
F
D
A
F
T
F
D
-
F
Y
A
S
M
L
N
A
A
R
L
I
I
A
D
E
H
T
L
L
D
T
E
R
L
T
D
L
I
L
Q
E
N
V
N
V
M
F
A
T
T
A
L
F
N
L
L
T
D
A
G
---
E
D
W
M
K
G
L
R
C
I
L
F
G
G
E
R
A
S
V
P
H
V
R
K
A
L
R
I
M
G
P
G
K
L
I
N
C
Y
G
P
T
E
G
T
V
F
A
T
A
H
V
V
H
D
L
-
P
D
S
I
S
S
L
P
I
G
K
P
I
S
N
A
S
V
Y
I
L
N
E
Q
S
Q
-----
L
Q
-----
P
-
F
G
A
V
G
E
L
C
I
S
G
M
G
V
S
K
G
Y
V
N
R
A
D
L
T
K
E
K
F
I
E
N
----
P
FKP-
G
E
T
L
Y
R
T
G
D
-
L
A
-
R
W
L
P
D
G
T
I
E
Y
A
G
R
I
D
D
Q
V
K
I
R
G
H
R
I
E
L
E
E
I
E
K
Q
L
Q
E
Y
P
G
V
K
D
A
V
V
V
A
-
D
------
R
H
E
S
G
--
D
A
S
I
N
A
Y
L
V
N
R
T
---
Q
-------
L
S
A
E
D
-
V
K
A
H
L
K
K
Q
L
P
A
Y
M
V
P
Q
T
F
T
F
L
D
E
L
P
L
T
T
N
G
K
V
N
K
R
L
L
P
K
P
----------------------------------------------------------------------------------
10
PsiBlast_PDB
56.09
30%
8
- C2 -
1AMU
4
GRSA_ANEMI
A:
[53-525]
-----------------------
P
N
N
V
A
I
V
C
E
N
E
Q
L
T
Y
H
E
L
N
V
K
A
N
Q
L
A
R
I
F
I
E
K
G
I
G
K
-
D
T
L
V
G
I
M
M
E
K
S
I
D
--
L
F
I
G
I
L
A
V
L
K
A
G
G
A
Y
V
P
I
D
I
E
Y
P
K
E
R
I
Q
Y
I
L
-
D
D
S
Q
A
R
M
L
L
T
------
Q
K
H
L
V
----
H
L
I
---
H
---
N
I
-
Q
------
F
N
--
G
----
Q
V
E
I
----
F
E
-
E
D
-----------
T
----
I
K
I
R
E
G
T
N
L
HVPS
K
S
T
-----
D
L
A
Y
V
I
Y
T
S
-----
P
K
G
T
M
L
E
H
K
G
I
S
N
L
K
V
-
F
F
E
N
S
--
L
-
N
V
T
E
K
D
R
I
G
Q
F
A
S
I
S
F
D
A
S
V
W
E
-
M
F
M
A
L
L
T
G
A
S
L
Y
I
I
L
K
D
T
I
N
D
F
V
K
F
E
Q
Y
I
N
Q
K
E
I
T
V
I
T
L
P
P
T
Y
V
--
V
H
L
D
P
----
E
R
I
L
S
I
Q
T
L
I
T
A
G
S
A
T
S
P
S
L
V
N
K
W
K
E
---
K
V
T
Y
I
N
A
Y
G
P
T
E
T
T
I
C
A
T
T
W
V
A
T
K
E
T
I
G
H
S
--
V
P
I
G
A
P
I
Q
N
T
Q
I
Y
I
V
D
E
N
L
Q
-----
L
K
-----
S
-
V
G
E
A
G
E
L
C
I
G
G
E
G
L
A
R
G
Y
W
K
R
P
E
L
T
S
Q
K
F
V
D
N
----
P
FVP-
G
E
K
L
Y
K
T
G
D
Q
A
R
-
W
L
S
-
D
G
N
I
E
Y
L
G
R
I
D
N
Q
V
K
I
R
G
H
R
V
E
L
E
E
V
E
S
I
L
L
K
H
M
Y
I
S
E
T
A
V
S
V
-
H
------
K
D
H
Q
E
--
Q
P
Y
L
C
A
Y
F
V
S
E
K
---
H
I
P
L
E
Q
L
R
Q
F
S
S
--------
E
E
L
P
T
Y
M
I
P
S
Y
F
I
Q
L
D
K
M
P
L
T
S
N
G
K
I
D
R
K
Q
L
P
E
-----------------------------------------------------------------------------------
26
PsiBlast_CBE
50.95
31%
-46
- C2 -
4OXI
1
?
A:
[212-567]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
H
-----
E
Y
A
Y
I
M
Q
T
S
G
S
T
G
K
P
K
R
I
A
V
S
Y
S
N
L
H
C
Y
I
S
-
Q
I
D
K
L
--
F
-
P
L
N
A
Q
D
R
V
G
Q
Y
S
D
L
T
F
D
L
S
V
H
D
-
I
F
Y
S
L
I
S
G
A
C
L
Y
V
V
P
E
L
A
K
L
S
P
A
---
E
F
I
H
H
H
Q
L
T
V
W
L
S
V
P
T
V
I
E
L
A
L
Q
R
Q
T
L
T
P
H
S
L
P
S
L
R
L
S
F
F
C
G
Q
A
L
L
H
D
L
A
E
Q
W
-
Q
Q
A
T
Q
Q
P
V
I
N
L
Y
G
P
T
E
C
T
I
A
V
T
Y
H
R
F
V
A
H
--
S
G
M
A
S
V
P
I
G
R
A
F
E
E
E
C
L
A
I
I
N
E
Q
G
E
-----
L
M
R
FESA
P
-
E
G
Y
R
G
E
L
L
L
S
G
K
Q
L
V
K
G
Y
L
N
D
P
L
N
T
Q
S
A
F
F
Q
H
----
E
----
G
R
L
W
Y
R
S
G
D
-
I
V
-
T
K
S
-
N
G
V
L
I
H
L
G
R
R
D
H
Q
V
K
I
A
G
Q
R
V
E
L
E
E
I
E
T
V
V
R
R
V
T
Q
A
H
S
V
A
I
V
P
-
W
PLSESG
Y
A
S
G
T
--
V
-----
A
F
V
D
T
H
---
T
-
Q
W
Q
P
D
L
W
L
-
S
Q
-
C
K
Q
Q
L
N
P
T
F
----
V
P
K
R
W
Y
A
I
E
Q
L
P
R
----
K
T
D
I
K
A
L
Q
Q
Q
L
---------------------------------------------------------------------------------