@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu38810: (2016-08-04 )
MAELRMEHIYKFYDQKEPAVDDFNLHIADKEFIVFVGPSGCGKSTTLRMVAGLEEISKGDFYIEGKRVNDVAPKDRDIAMVFQNYALYPHMTVYDNIAFGLKLRKMPKPEIKKRVEEAAKILGLEEYLHRKPKALSGGQRQRVALGRAIVRDAKVFLMDEPLSNLDAKLRVQMRAEIIKLHQRLQTTTIYVTHDQTEALTMATRIVVMKDGKIQQIGTPKDVYEFPENVFVGGFIGSPAMNFFKGKLTDGLIKIGSAALTVPEGKMKVLREKGYIGKEVIFGIRPEDIHDELIVVESYKNSSIKAKINVAELLGSEIMIYSQIDNQDFIARIDARLDIQSGDELTVAFDMNKGHFFDSETEVRIR
Atome Classification :
(47 SA)
.........10.......---.20........30........40........50........60.......----.----70-----.....-----..-..80........90----.........100.---..---.....110.......120....-...130.......140.......150.......160.......170.......180....---...190.......200.......210.......220.......230.......240......-.250---.-----..--.-...260..--.---....270..---.....280.......290..-...--..300.......310.......320...--.--...330.......340.......350.......360...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MA
E
L
R
M
E
H
I
Y
K
F
Y
DQKEP---AVDD
F
N
L
H
IAD
K
E
F
I
V
F
VGPSGCGKS
T
T
L
R
M
V
A
G
L
E
E
ISKG
D
F
Y
I
EGKRV----N----D------VAPKD-----
R
D
-
I
A
M
V
F
Q
NYALYPH-----
M
T
VYDN
I
A
F
G
-
L
K
---LR---KMP
K
P
E
I
K
K
R
V
E
E
A
A
K
I
L
G
L
E
E
-
Y
L
H
RKPKALSGGQ
R
Q
R
V
A
L
G
R
A
I
VRD
A
K
V
F
L
MDEPLSNL
D
A
K
L
R
V
Q
M
R
A
E
I
I
K
L
H
Q
RLQ
T
---
T
T
I
Y
V
THDQT
E
A
L
T
M
A
T
R
I
V
V
M
KDG
K
I
Q
QIGT
P
K
D
V
Y
EFPE
N
V
F
VGGFIGS
P
A
M
N
F
F
KGKLT-D
G
L
I
---K-----IG--
S
-
A
A
L
TVPE
G
--
K
---
M
K
V
L
R
EKGY---IG
K
E
V
I
F
GIRPEDIHD
E
L
I
V
-
V
E
S--YKNS
S
I
K
A
K
I
N
V
A
E
LLGS
E
I
M
I
Y
S
QID
N
--
Q
--
D
F
I
A
RI
D
A
R
L
D
IQSGD
E
L
T
V
A
F
DMNKGHFFDSE
T
E
V
R
IR
7
PsiBlast_PDB
84.46
48%
-132
- C2 -
1V43
-
?
A:
[10-369]
M
V
E
V
K
L
E
N
L
T
K
R
F
G
N
F
T
----
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
R
D
V
----
T
----
Y
------
L
P
P
K
D
-----
R
N
-
I
S
M
V
F
Q
------
H
-----
M
T
V
Y
E
N
I
A
F
P
-
L
-----
K
---
K
F
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
E
E
-
L
L
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
V
---
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
G
A
P
E
M
N
I
L
E
V
S
V
G
-
D
G
Y
L
---
E
-----
G
R
--
G
-
F
R
I
E
L
P
Q
-------
M
D
L
L
K
D
--
Y
---
V
G
K
T
V
L
F
G
I
R
P
E
H
M
T
V
E
G
V
---
H
M
--
K
R
T
A
R
L
I
G
K
V
D
F
V
E
A
L
G
T
D
T
I
L
H
V
K
F
G
D
--
E
--
L
V
K
V
K
L
P
G
H
I
P
I
E
P
G
R
E
V
K
V
I
M
D
L
D
M
I
H
V
F
D
K
D
T
E
----
6
PsiBlast_PDB
83.92
48%
-129
- C2 -
1VCI
1
?
A:
[10-369]
M
V
E
V
K
L
E
N
L
T
K
R
F
G
N
F
T
----
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
R
D
V
----
T
----
Y
------
L
P
P
K
D
-----
R
N
-
I
S
M
V
F
Q
------
H
-----
M
T
V
Y
E
N
I
A
F
P
-
L
-----
K
---
K
F
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
E
E
-
L
L
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
V
---
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
G
A
P
E
M
N
I
L
E
V
S
V
G
-
D
G
Y
L
---
E
-----
G
R
--
G
-
F
R
I
E
L
P
Q
-------
M
D
L
L
K
D
--
Y
---
V
G
K
T
V
L
F
G
I
R
P
E
H
M
T
V
E
G
V
---
H
M
--
K
R
T
A
R
L
I
G
K
V
D
F
V
E
A
L
G
T
D
T
I
L
H
V
K
F
G
D
--
E
--
L
V
K
V
K
L
P
G
H
I
P
I
E
P
G
R
E
V
K
V
I
M
D
L
D
M
I
H
V
F
D
K
D
T
E
----
95
HHSearch
82.97
49%
-116
- C2 -
1V43
-
?
A:
[10-372]
M
V
E
V
K
L
E
N
L
T
K
R
F
G
-
N
F
T
---
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
R
D
V
----
T
----
Y
------
L
P
P
K
D
-----
R
N
-
I
S
M
V
F
Q
------
H
-----
M
T
V
Y
E
N
I
A
F
P
-
L
-----
K
---
K
F
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
E
E
-
L
L
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
L
K
V
---
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
G
A
P
E
M
N
I
L
E
V
S
V
G
-
D
G
Y
L
---
E
-----
G
R
--
G
-
F
R
I
E
L
P
Q
-------
M
--
D
L
L
K
D
Y
---
V
G
K
T
V
L
F
G
I
R
P
E
H
M
T
V
E
G
V
-----HM
K
R
T
A
R
L
I
G
K
V
D
F
V
E
A
L
G
T
D
T
I
L
H
V
K
F
G
D
--
E
--
L
V
K
V
K
L
P
G
H
I
P
I
E
P
G
R
E
V
K
V
I
M
D
L
D
M
I
H
V
F
D
K
D
T
E
K
A
I
-
4
PsiBlast_PDB
82.77
51%
-78
- C2 -
4XIG
-
?
S:
[2-362]
V
A
S
V
S
I
Q
N
V
V
K
R
Y
D
-
K
T
T
---
V
V
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
I
S
G
G
T
I
R
I
D
G
R
V
I
----
N
----
D
------
L
A
P
K
D
-----
R
D
-
V
A
M
V
F
Q
N
Y
A
L
Y
P
H
-----
L
N
V
R
D
N
I
S
F
G
-
L
R
---
L
K
---
R
T
K
K
S
V
I
D
A
A
V
K
T
A
A
D
I
L
G
L
Q
P
-
L
L
E
R
K
P
S
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
T
Q
M
R
A
E
I
K
R
L
H
Q
R
L
G
T
---
T
V
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
R
I
V
V
M
R
D
G
L
I
E
Q
I
G
K
P
M
D
L
F
L
H
P
A
N
T
F
V
A
S
F
I
G
S
P
P
M
N
L
M
P
A
R
------
I
---
A
-----
V
D
--
S
-
T
Q
H
V
E
L
N
G
GN
R
---
I
S
L
L
P
R
A
G
T
HLA
P
G
Q
E
V
V
F
G
I
R
P
E
D
V
--
T
L
D
G
-
V
E
G
--
S
E
R
A
Q
I
K
A
T
V
D
I
V
E
P
L
G
S
E
S
I
L
H
A
T
V
G
D
--
H
--
S
L
V
V
K
V
G
G
L
N
E
V
H
P
G
D
P
V
T
L
H
V
D
L
T
R
V
H
L
F
D
A
Q
S
Q
A
S
I
-
5
PsiBlast_PDB
81.94
51%
-79
- C2 -
4XTC
-
?
S:
[2-362]
V
A
S
V
S
I
Q
N
V
V
K
R
Y
D
-
K
T
T
---
V
V
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
I
S
G
G
T
I
R
I
D
G
R
V
I
----
N
----
D
------
L
A
P
K
D
-----
R
D
-
V
A
M
V
F
Q
N
Y
A
L
Y
P
H
-----
L
N
V
R
D
N
I
S
F
G
-
L
R
---
L
K
---
R
T
K
K
S
V
I
D
A
A
V
K
T
A
A
D
I
L
G
L
Q
P
-
L
L
E
R
K
P
S
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
T
Q
M
R
A
E
I
K
R
L
H
Q
R
L
G
T
---
T
V
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
R
I
V
V
M
R
D
G
L
I
E
Q
I
G
K
P
M
D
L
F
L
H
P
A
N
T
F
V
A
S
F
I
G
S
P
P
M
N
L
M
P
A
R
------
I
---
A
-----
V
D
--
S
-
T
Q
H
V
E
L
N
G
GN
R
---
I
S
L
L
P
R
A
G
T
HLA
P
G
Q
E
V
V
F
G
I
R
P
E
D
V
--
T
L
D
G
-
V
E
G
--
S
E
R
A
Q
I
K
A
T
V
D
I
V
E
P
L
G
S
E
S
I
L
H
A
T
V
G
D
--
H
--
S
L
V
V
K
V
G
G
L
N
E
V
H
P
G
D
P
V
T
L
H
V
D
L
T
R
V
H
L
F
D
A
Q
S
Q
A
S
I
-
3
PsiBlast_PDB
80.37
51%
-79
- C2 -
4TQV
-
?
C:
[2-362]
V
A
S
V
S
I
Q
N
V
V
K
R
Y
D
-
K
T
T
---
V
V
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
I
S
G
G
T
I
R
I
D
G
R
V
I
----
N
----
D
------
L
A
P
K
D
-----
R
D
-
V
A
M
V
F
Q
N
Y
A
L
Y
P
H
-----
L
N
V
R
D
N
I
S
F
G
-
L
R
---
L
K
---
R
T
K
K
S
V
I
D
A
A
V
K
T
A
A
D
I
L
G
L
Q
P
-
L
L
E
R
K
P
S
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
T
Q
M
R
A
E
I
K
R
L
H
Q
R
L
G
T
---
T
V
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
R
I
V
V
M
R
D
G
L
I
E
Q
I
G
K
P
M
D
L
F
L
H
P
A
N
T
F
V
A
S
F
I
G
S
P
P
M
N
L
M
P
A
R
------
I
---
A
-----
V
D
--
S
-
T
Q
H
V
E
L
N
G
G
N
R
---
I
S
L
L
P
R
A
G
T
HLA
P
G
Q
E
V
V
F
G
I
R
P
E
D
V
--
T
L
D
G
-
V
E
G
--
S
E
R
A
Q
I
K
A
T
V
D
I
V
E
P
L
G
S
E
S
I
L
H
A
T
V
G
D
--
H
--
S
L
V
V
K
V
G
G
L
N
E
V
H
P
G
D
P
V
T
L
H
V
D
L
T
R
V
H
L
F
D
A
Q
S
Q
A
S
I
-
2
PsiBlast_PDB
80.37
51%
-79
- C2 -
4TQU
-
?
S:
[2-362]
V
A
S
V
S
I
Q
N
V
V
K
R
Y
D
-
K
T
T
---
V
V
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
I
S
G
G
T
I
R
I
D
G
R
V
I
----
N
----
D
------
L
A
P
K
D
-----
R
D
-
V
A
M
V
F
Q
N
Y
A
L
Y
P
H
-----
L
N
V
R
D
N
I
S
F
G
-
L
R
---
L
K
---
R
T
K
K
S
V
I
D
A
A
V
K
T
A
A
D
I
L
G
L
Q
P
-
L
L
E
R
K
P
S
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
T
Q
M
R
A
E
I
K
R
L
H
Q
R
L
G
T
---
T
V
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
R
I
V
V
M
R
D
G
L
I
E
Q
I
G
K
P
M
D
L
F
L
H
P
A
N
T
F
V
A
S
F
I
G
S
P
P
M
N
L
M
P
A
R
------
I
---
A
-----
V
D
--
S
-
T
Q
H
V
E
L
N
G
GN
R
---
I
S
L
L
P
R
A
G
T
HLA
P
G
Q
E
V
V
F
G
I
R
P
E
D
V
--
T
L
D
G
-
V
E
G
--
S
E
R
A
Q
I
K
A
T
V
D
I
V
E
P
L
G
S
E
S
I
L
H
A
T
V
G
D
--
H
--
S
L
V
V
K
V
G
G
L
N
E
V
H
P
G
D
P
V
T
L
H
V
D
L
T
R
V
H
L
F
D
A
Q
S
Q
A
S
I
-
94
HHSearch
79.75
51%
-79
- C2 -
4TQU
-
?
S:
[2-362]
V
A
S
V
S
I
Q
N
V
V
K
R
Y
D
-
K
T
T
---
V
V
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
I
S
G
G
T
I
R
I
D
G
R
V
I
----
N
----
D
------
L
A
P
K
D
-----
R
D
-
V
A
M
V
F
Q
N
Y
A
L
Y
P
H
-----
L
N
V
R
D
N
I
S
F
G
-
L
R
---
L
K
---
R
T
K
K
S
V
I
D
A
A
V
K
T
A
A
D
I
L
G
L
Q
P
-
L
L
E
R
K
P
S
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
T
Q
M
R
A
E
I
K
R
L
H
Q
R
L
G
T
---
T
V
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
R
I
V
V
M
R
D
G
L
I
E
Q
I
G
K
P
M
D
L
F
L
H
P
A
N
T
F
V
A
S
F
I
G
S
P
P
M
N
L
M
P
A
R
I
A
-
V
D
S
T
QHV
E
-----
L
N
G-
G
-
N
R
I
S
L
L
P
R
---------
A
G
T
H
L
A
---
P
G
Q
E
V
V
F
G
I
R
P
E
D
V
T
L
D
G
V
E
-
G
----
S
E
R
A
Q
I
K
A
T
V
D
I
V
E
P
L
G
S
E
S
I
L
H
A
T
V
G
D
--
H
--
S
L
V
V
K
V
G
G
L
N
E
V
H
P
G
D
P
V
T
L
H
V
D
L
T
R
V
H
L
F
D
A
Q
S
Q
A
S
I
-
100
HHSearch
78.09
45%
-86
- C2 -
3RLF
3
MALK_ECOLI
A:
[2-362]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
G
-
E
V
V
---
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
----
D
------
T
P
P
A
E
-----
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
-----
L
S
V
A
E
N
M
S
F
G
-
L
K
---
L
A
---
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
---
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
-
A
T
A
I
---
D
Q
V
Q
V
E
L
P
MP
N
R
Q
Q
V
W
L
P
V
E
----------
S
R
D
V
Q
---
V
G
A
N
M
S
L
G
I
R
P
E
H
L
L
P
S
D
I
A
--------
D
V
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
--
I
R
Q
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
R
E
D
G
T
A
C
--
15
PsiBlast_PDB
78.06
44%
-85
- C2 -
3PUZ
2
MALK_ECOLI
A:
[2-355]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
---
S
-
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
----
D
------
T
P
P
A
E
-----
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
-----
L
S
V
A
E
N
M
S
F
G
-
L
K
---
L
A
---
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
---
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
-
A
T
A
I
---
D
-----
Q
V
--
Q
-
V
E
L
P
M
P
N
R
--
Q
Q
V
W
L
P
V
E
S
R
D
V
Q
---
V
G
A
N
M
S
L
G
I
R
P
E
H
-----
L
L
-
P
S
D
--
I
A
D
V
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
IR
Q
--
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
---------
17
PsiBlast_PDB
77.83
44%
-84
- C2 -
3PUV
5
MALK_ECOLI
A:
[2-355]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
---
S
-
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
----
D
------
T
P
P
A
E
-----
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
-----
L
S
V
A
E
N
M
S
F
G
-
L
K
---
L
A
---
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
---
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
-
A
T
A
I
---
D
-----
Q
V
--
Q
-
V
E
L
P
M
P
N
R
--
Q
Q
V
W
L
P
V
E
S
R
D
V
Q
---
V
G
A
N
M
S
L
G
I
R
P
E
H
-----
L
L
-
P
S
D
--
I
A
D
V
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
IR
Q
--
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
---------
19
PsiBlast_PDB
77.60
44%
-82
- C2 -
3PUX
5
MALK_ECOLI
A:
[2-355]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
---
S
-
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
----
D
------
T
P
P
A
E
-----
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
-----
L
S
V
A
E
N
M
S
F
G
-
L
K
---
L
A
---
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
---
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
-
A
T
A
I
---
D
-----
Q
V
--
Q
-
V
E
L
P
M
P
N
R
--
Q
Q
V
W
L
P
V
E
S
R
D
V
Q
---
V
G
A
N
M
S
L
G
I
R
P
E
H
-----
L
L
-
P
S
D
--
I
A
D
V
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
IR
Q
--
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
---------
1
PsiBlast_PDB
77.31
53%
9
- C2 -
2D62
8
?
A:
[5-371]
-
A
E
V
K
L
I
N
I
W
K
R
F
G
D
V
T
----
A
V
K
D
L
S
L
E
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
R
G
Q
I
Y
I
E
D
N
L
V
----
A
----
D
PEKG
V
F
V
P
P
K
E
-----
R
D
-
V
A
M
V
F
Q
S
Y
A
L
Y
P
H
-----
M
T
V
Y
D
N
I
A
F
P
-
L
K
---
L
R
---
K
V
P
K
Q
E
I
D
K
R
V
R
E
V
A
E
M
L
G
L
T
E
-
L
L
N
R
K
P
R
E
L
S
G
G
Q
R
Q
R
V
A
L
G
R
A
I
I
R
R
P
K
V
F
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
K
M
R
A
E
L
K
K
L
Q
R
Q
L
G
V
---
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
K
G
E
L
Q
Q
V
G
T
P
D
E
V
Y
Y
K
P
V
N
T
F
V
A
G
F
I
G
S
P
P
M
N
F
L
D
A
T
I
T
D
D
G
F
L
---
D
-----
F
G
--
E
-
F
K
L
K
L
L
Q
D
--
Q
---
F
E
V
L
E
E
E
N
M
---
V
G
K
E
V
I
F
G
I
R
P
E
D
V
H
D
A
S
F
T
H
I
D
V
--
P
E
E
N
T
V
K
A
T
V
D
I
I
E
N
L
G
G
E
K
I
V
H
L
R
R
G
N
--
I
--
S
F
T
A
K
F
P
K
E
S
K
V
R
E
G
D
E
V
S
V
V
F
D
M
K
K
I
H
I
F
R
K
D
T
E
----
20
PsiBlast_PDB
76.86
44%
-83
- C2 -
3RLF
3
MALK_ECOLI
A:
[2-355]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
---
S
-
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
----
D
------
T
P
P
A
E
-----
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
-----
L
S
V
A
E
N
M
S
F
G
-
L
K
---
L
A
---
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
---
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
-
A
T
A
I
---
D
-----
Q
V
--
Q
-
V
E
L
P
M
P
N
R
--
Q
Q
V
W
L
P
V
E
S
R
D
V
Q
---
V
G
A
N
M
S
L
G
I
R
P
E
H
-----
L
L
-
P
S
D
--
I
A
D
V
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
IR
Q
--
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
---------
34
PsiBlast_CBE
76.50
44%
-77
- C2 -
2R6G
2
MALK_ECOLI (first)
A:
[2-355]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
---
S
-
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
----
D
------
T
P
P
A
E
-----
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
-----
L
S
V
A
E
N
M
S
F
G
-
L
K
---
L
A
---
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
Q
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
---
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
-
A
T
A
I
---
D
-----
Q
V
--
Q
-
V
E
L
P
M
P
N
R
--
Q
Q
V
W
L
P
V
E
S
R
D
V
Q
---
V
G
A
N
M
S
L
G
I
R
P
E
H
-----
L
L
-
P
S
D
--
I
A
D
V
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
IR
Q
--
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
---------
18
PsiBlast_PDB
76.41
44%
-80
- C2 -
3PUW
5
MALK_ECOLI
A:
[2-355]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
---
S
-
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
----
D
------
T
P
P
A
E
-----
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
-----
L
S
V
A
E
N
M
S
F
G
-
L
K
---
L
A
---
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
---
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
-
A
T
A
I
---
D
-----
Q
V
--
Q
-
V
E
L
P
M
P
N
R
--
Q
Q
V
W
L
P
V
E
S
R
D
V
Q
---
V
G
A
N
M
S
L
G
I
R
P
E
H
-----
L
L
-
P
S
D
--
I
A
D
V
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
IR
Q
--
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
---------
22
PsiBlast_CBE
76.18
44%
-82
- C2 -
4KI0
4
MALK_ECOLI
A:
[2-355]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
---
S
-
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
----
D
------
T
P
P
A
E
-----
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
-----
L
S
V
A
E
N
M
S
F
G
-
L
K
---
L
A
---
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
---
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
-
A
T
A
I
---
D
-----
Q
V
--
Q
-
V
E
L
P
M
P
N
R
--
Q
Q
V
W
L
P
V
E
S
R
D
V
Q
---
V
G
A
N
M
S
L
G
I
R
P
E
H
-----
L
L
-
P
S
D
--
I
A
D
V
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
IR
Q
--
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
---------
21
PsiBlast_CBE
75.93
44%
-82
- C2 -
4KI0
3
MALK_ECOLI
B:
[2-355]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
---
S
-
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
----
D
------
T
P
P
A
E
-----
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
-----
L
S
V
A
E
N
M
S
F
G
-
L
K
---
L
A
---
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
---
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
-
A
T
A
I
---
D
-----
Q
V
--
Q
-
V
E
L
P
M
P
N
R
--
Q
QVW
L
P
V
E
S
R
D
V
Q
---
V
G
A
N
M
S
L
G
I
R
P
E
H
-----
L
L
-
P
S
D
--
I
A
D
V
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
IR
Q
--
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
---------
14
PsiBlast_PDB
75.80
44%
-80
- C2 -
3PUY
3
MALK_ECOLI
A:
[2-355]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
---
S
-
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
----
D
------
T
P
P
A
E
-----
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
-----
L
S
V
A
E
N
M
S
F
G
-
L
K
---
L
A
---
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
---
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
-
A
T
A
I
---
D
-----
Q
V
--
Q
-
V
E
L
P
M
P
N
R
--
Q
Q
V
W
L
P
V
E
S
R
D
V
Q
---
V
G
A
N
M
S
L
G
I
R
P
E
H
-----
L
L
-
P
S
D
--
I
A
D
V
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
IR
Q
--
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
---------
16
PsiBlast_PDB
75.78
44%
-76
- C2 -
3PV0
-
MALK_ECOLI
A:
[2-355]
-
A
S
V
Q
L
Q
N
V
T
K
A
W
G
E
V
V
V
---
S
-
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
----
N
----
D
------
T
P
P
A
E
-----
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
-----
L
S
V
A
E
N
M
S
F
G
-
L
K
---
L
A
---
G
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
---
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
H
Y
P
A
D
R
F
V
A
G
F
I
G
S
P
K
M
N
F
L
P
V
K
V
T
-
A
T
A
I
---
D
-----
Q
V
--
Q
-
V
E
L
P
M
P
N
R
--
Q
Q
V
W
L
P
V
E
S
R
D
V
Q
---
V
G
A
N
M
S
L
G
I
R
P
E
H
-----
L
L
-
P
S
D
--
I
A
D
V
I
L
E
G
E
V
Q
V
V
E
Q
L
G
N
E
T
Q
I
H
I
Q
I
P
S
IR
Q
--
N
L
V
Y
R
Q
N
D
V
V
L
V
E
E
G
A
T
F
A
I
G
L
P
P
E
R
C
H
L
F
---------
49
PsiBlast_CBE
47.72
37%
-24
- C2 -
3FVQ
3
FBPC_NEIG1
B:
[3-240]
-
A
A
L
H
I
G
H
L
S
K
S
F
-
Q
N
T
P
---
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
FSKN
T
----
N
------
L
P
V
R
E
-----
R
R
-
L
G
Y
L
V
Q
E
G
V
L
F
P
H
-----
L
T
V
Y
R
N
I
A
Y
G
-
L
G
---
N
G
---
K
G
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
S
E
-
L
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
---
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
47.03
37%
-19
- C2 -
3FVQ
3
FBPC_NEIG1
A:
[3-245]
-
A
A
L
H
I
G
H
L
S
K
S
F
-
Q
N
T
P
---
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
FSKN
T
----
N
------
L
P
V
R
E
-----
R
R
-
L
G
Y
L
V
Q
E
G
V
L
F
P
H
-----
L
T
V
Y
R
N
I
A
Y
G
-
L
G
---
N
G
---
K
G
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
S
E
-
L
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
---
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
------------------------------------------------------------------------------------------------------------------------------------------------------------
101
HHSearch
46.02
30%
-6
- C2 -
3FVQ
3
FBPC_NEIG1
A:
[2-349]
T
A
A
L
H
I
G
H
L
S
K
S
F
Q
-
N
T
P
---
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
I
----
F
SKN
T
N
------
L
P
V
R
E
-----
R
R
-
L
G
Y
L
V
Q
E
G
V
L
F
P
H
-----
L
T
V
Y
R
N
I
A
Y
G
-
L
G
---
N
G
---
K
G
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
S
E
-
L
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
---
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
E
G
--
I
V
F
P
A
A
L
N
-
A
D
G
T
A
--
D
-----
C
R
--
L
-
G
R
L
P
V
Q
-------------
S
G
A
P
---
A
G
T
R
G
T
L
L
I
R
P
E
Q
Y
S
L
H
P
H
S
-
A
-----
P
A
A
S
I
H
A
V
V
L
K
T
T
P
K
A
R
H
T
E
I
S
L
R
A
G
Q
--
T
--
V
L
T
L
N
L
-----
L
S
D
G
I
S
A
V
L
H
L
D
G
P
A
L
F
F
P
G
--------
78
PsiBlast_CBE
45.07
34%
-15
- C2 -
4YMV
1
?
J:
[7-224]
--------
V
Y
K
N
F
G
S
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
----
N
----
N
GKVN--
I
N
K
V
R
-----
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
-----
L
T
A
I
E
N
I
T
L
A
P
V
K
---
V
K
---
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
-
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
EGM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
44.33
35%
-7
- C2 -
3C4J
4
?
B:
[44-252]
--------------------------
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD
T
----
N
------
L
N
K
V
R
-----
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
-----
M
T
V
L
N
N
I
T
L
A
P
M
K
---
V
R
---
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
EGM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
44.16
34%
-11
- C2 -
4YMV
1
?
A:
[7-224]
--------
V
Y
K
N
F
G
S
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
----
N
----
N
GKVN--
I
N
K
V
R
-----
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
-----
L
T
A
I
E
N
I
T
L
A
P
V
K
---
V
K
---
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
-
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
43.77
35%
-14
- C2 -
3C41
3
?
J:
[23-238]
--------------------------
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD
T
----
N
------
L
N
K
V
R
-----
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
-----
M
T
V
L
N
N
I
T
L
A
P
M
K
---
V
R
---
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
EGM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
43.49
35%
-18
- C2 -
3C41
3
?
K:
[23-238]
--------------------------
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD
T
----
N
------
L
N
K
V
R
-----
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
-----
M
T
V
L
N
N
I
T
L
A
P
M
K
---
V
R
---
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
EGM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
42.90
35%
-11
- C2 -
2OLK
1
?
D:
[44-252]
--------------------------
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD
T
----
N
------
L
N
K
V
R
-----
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
-----
M
T
V
L
N
N
I
T
L
A
P
M
K
---
V
R
---
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
EGM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
42.84
35%
-10
- C2 -
2OLK
2
?
B:
[44-252]
--------------------------
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD
T
----
N
------
L
N
K
V
R
-----
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
-----
M
T
V
L
N
N
I
T
L
A
P
M
K
---
V
R
---
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
EGM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
42.49
35%
-14
- C2 -
2OLK
1
?
A:
[44-252]
--------------------------
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAK
D
T
----
N
------
L
N
K
V
R
-----
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
-----
M
T
V
L
N
N
I
T
L
A
P
M
K
---
V
R
---
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
GM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
42.35
35%
-8
- C2 -
3C4J
3
?
A:
[44-252]
--------------------------
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD
T
----
N
------
L
N
K
V
R
-----
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
-----
M
T
V
L
N
N
I
T
L
A
P
M
K
---
V
R
---
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
GM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
42.34
35%
-14
- C2 -
2Q0H
4
?
B:
[44-252]
--------------------------
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD
T
----
N
------
L
N
K
V
R
-----
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
-----
M
T
V
L
N
N
I
T
L
A
P
M
K
---
V
R
---
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
GM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
42.27
33%
20
- C2 -
3TIF
7
Y796_METJA
B:
[2-225]
---
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
IIY
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
----
N
----
D
------
L
D
D
D
E
LTKIR
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
-----
L
T
A
L
E
N
V
E
L
P
-
L
I
---
F
K
YRG
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
---
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
41.92
35%
-9
- C2 -
2OLJ
3
?
B:
[44-252]
--------------------------
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD
T
----
N
------
L
N
K
V
R
-----
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
-----
M
T
V
L
N
N
I
T
L
A
P
M
K
---
V
R
---
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
EGM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
41.91
31%
-25
- C2 -
4U00
3
?
A:
[5-238]
---
I
R
I
R
N
L
H
K
W
F
G
P
L
H
----
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
----
K
----
D
DRA---
L
R
E
I
R
-----
R
E
-
V
G
M
V
F
Q
Q
F
N
L
F
P
H
-----
M
T
V
L
E
N
V
T
L
A
P
M
R
---
V
R
---
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
-
Q
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
41.84
33%
22
- C2 -
3TIF
7
Y796_METJA
A:
[2-225]
---
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
----
N
----
D
------
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
-----
L
T
A
L
E
N
V
E
L
P
-
L
I
---
F
K
YR
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
---
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
41.76
34%
-14
- C2 -
4YMU
2
?
J:
[7-224]
--------
V
Y
K
N
F
G
S
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
----
N
----
N
GKVN--
I
N
K
V
R
-----
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
-----
L
T
A
I
E
N
I
T
L
A
P
V
K
---
V
K
---
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
-
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
EGM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
41.69
35%
-5
- C2 -
2OLJ
4
?
A:
[44-252]
--------------------------
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD
T
----
N
------
L
N
K
V
R
-----
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
-----
M
T
V
L
N
N
I
T
L
A
P
M
K
---
V
R
---
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
GM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
41.56
35%
-14
- C2 -
2OLK
1
?
C:
[44-252]
--------------------------
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD
T
----
N
------
L
N
K
V
R
-----
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
-----
M
T
V
L
N
N
I
T
L
A
P
M
K
---
V
R
---
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
EGM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
41.34
34%
-16
- C2 -
4YMU
2
?
A:
[7-224]
--------
V
Y
K
N
F
G
S
L
E
----
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
----
N
----
N
GKVN--
I
N
K
V
R
-----
Q
K
-
V
G
M
V
F
Q
H
F
N
L
F
P
H
-----
L
T
A
I
E
N
I
T
L
A
P
V
K
---
V
K
---
K
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
D
-
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
GM
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
40.68
35%
-10
- C2 -
2Q0H
4
?
A:
[44-252]
--------------------------
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
KAKD
T
----
N
------
L
N
K
V
R
-----
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
-----
M
T
V
L
N
N
I
T
L
A
P
M
K
---
V
R
---
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
-
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
40.54
33%
27
- C2 -
1L2T
4
Y796_METJA
B:
[2-225]
---
I
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
IIY
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
----
N
----
D
------
L
D
D
D
E
LTKIR
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
-----
L
T
A
L
E
N
V
E
L
P
-
L
I
---
F
K
YRG
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
---
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
40.32
33%
26
- C2 -
1L2T
4
Y796_METJA
A:
[2-225]
---
I
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
----
N
----
D
------
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
L
I
P
L
-----
L
T
A
L
E
N
V
E
L
P
-
L
I
---
F
K
YR
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
---
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
39.31
32%
-14
- C2 -
4HLU
2
ECFA2_THEMA
A:
[24-217]
---------------------
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
D
V
L
Y
D
G
E
R
K
----
K
----
G
------
Y
E
I
R
------
R
N
-
I
G
I
A
F
Q
----
Y
P
E
DQFFA
E
R
V
F
D
E
V
A
F
A
-
V
K
NFY
P
D
---
R
D
P
V
P
L
V
K
K
A
M
E
F
V
G
--
L
D
F
D
S
-
F
K
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
-
L
R
I
V
E
K
W
K
T
L
G
K
---
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
K
G
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
39.25
32%
-16
- C2 -
4HLU
3
ECFA2_THEMA
B:
[24-217]
---------------------
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
D
V
L
Y
D
G
E
R
K
----
K
----
G
------
Y
E
I
R
------
R
N
-
I
G
I
A
F
Q
----
Y
P
E
DQFFA
E
R
V
F
D
E
V
A
F
A
-
V
K
NFY
P
D
---
R
D
P
V
P
L
V
K
K
A
M
E
F
V
G
--
L
D
F
D
S
-
F
K
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
-
L
R
I
V
E
K
W
K
T
L
G
K
---
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
K
G
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
36.00
32%
-15
- C2 -
4ZIR
5
ECFA2_THEMA
A:
[23-216]
---------------------
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
D
V
L
Y
D
G
E
------
K
----
G
------
Y
E
I
R
------
R
N
-
I
G
I
A
F
Q
----
Y
P
E
DQFFA
E
R
V
F
D
E
V
A
F
A
-
V
K
NFY
P
D
---
R
D
P
V
P
L
V
K
K
A
M
E
F
V
G
--
L
D
F
D
S
-
F
K
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
-
L
R
I
V
E
K
W
K
T
L
G
K
---
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
K
G
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------