@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu38860: (2016-08-04 )
MAILVTGGAGYIGSHTCVELLNSGYEIVVLDNLSNSSAEALNRVKEITGKDLTFYEADLLDREAVDSVFAENEIEAVIHFAGLKAVGESVAIPLKYYHNNLTGTFILCEAMEKYGVKKIVFSSSATVYGVPETSPITEDFPLGATNPYGQTKLMLEQILRDLHTADNEWSVALLRYFNPFGAHPSGRIGEDPNGIPNNLMPYVAQVAVGKLEQLSVFGNDYPTKDGTGVRDYIHVVDLAEGHVKALEKVLNSTGADAYNLGTGTGYSVLEMVKAFEKVSGKEVPYRFADRRPGDIATCFADPAKAKRELGWEAKRGLEEMCADSWRWQSSNVNGYKSAE
Atome Classification :
(49 SA)
.........10........20........30....------.---.---..40........50........60........-70-........80........90........100.......110.......120..--------.....----130.----.---.....140-.-.-.....150.......160...-------------..-------------.-.170.......180.......190.........200.......210.......220.......230.......240.......----250........260.......270.......280.......290.......300.......310....-...---320.......330.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
I
L
V
TGGAGYI
G
S
H
T
C
V
E
L
L
NSG
Y
E
I
V
V
LDNLSN------
S
---
S
---
A
E
A
L
N
R
V
K
E
ITGKD
L
T
F
Y
E
A
D
LL
D
R
E
A
V
D
S
V
F
-
A
E
-
N
E
I
E
A
V
I
H
F
A
G
L
K
AVGES
V
A
I
P
L
K
Y
YHNNLT
G
T
F
I
L
C
E
A
M
E
KYG
V
K
K
I
V
FSSS--------
A
T
V
Y
G----VPET----S---PITEDFPL-G-A-TNPY
G
Q
T
K
L
M
L
E
Q
I
L
R
D
L
HTA-------------DN-------------
E
-
W
S
V
A
L
L
R
YFNPFGAHPSGRIGE--DPNGIP
N
N
L
M
P
Y
V
A
Q
V
A
VG
K
L
E
Q
L
S
VFGNDYPTKDGTG
V
R
D
Y
I
H
V
V
DLA
E
G
H
V
K
A
L
E
K
V
----
L
N
-STGA
D
A
Y
NLGTGT
G
Y
S
V
L
E
M
V
K
A
F
E
K
VSGKEV
P
Y
RFADRRPGD
I
A
T
CFA
D
P
A
K
A
K
R
ELG
W
E
A
K
R
G
-
L
E
E
---
M
CADS
W
R
WQSSNVNGYKSAE
72
HHSearch
99.14
65%
-98
- C1 -
3ENK
2
?
A:
[6-340]
G
T
I
L
V
T
G
G
A
G
Y
I
G
S
H
T
A
V
E
L
L
A
H
G
Y
D
V
V
I
A
D
N
L
V
N
------
S
---
K
---
R
E
A
I
A
R
I
E
K
I
T
G
K
T
P
A
F
H
E
T
D
V
S
D
E
R
A
L
A
R
I
F
-
D
A
-
H
P
I
T
A
A
I
H
F
A
A
L
K
A
V
G
E
S
V
A
K
P
I
E
Y
Y
R
N
N
L
D
S
L
L
S
L
L
R
V
M
R
E
R
A
V
K
R
I
V
F
S
S
S
--------
A
T
V
Y
G
----
V
P
E
R
----
S
---
P
I
D
E
T
F
P
L
-
S
-
A
-
T
N
P
Y
G
Q
T
K
L
M
A
E
Q
I
L
R
D
V
E
A
A
-------------
D
P
-------------
S
-
W
R
V
A
T
L
R
Y
F
N
P
V
G
A
H
E
S
G
L
I
G
E
--
D
P
A
G
I
P
N
N
L
M
P
Y
V
A
Q
V
A
V
G
K
L
E
K
L
R
V
F
G
S
D
Y
P
T
P
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
R
G
H
I
A
A
L
D
A
L
----
E
R
-
R
D
A
S
L
T
V
N
L
G
T
G
R
G
Y
S
V
L
E
V
V
R
A
F
E
K
A
S
G
R
A
V
P
Y
E
L
V
A
R
R
P
G
D
V
A
E
C
Y
A
N
P
A
A
A
A
E
T
I
G
W
K
A
E
R
D
-
L
E
R
---
M
C
A
D
H
W
R
W
Q
E
N
N
P
R
G
F
----
1
PsiBlast_PDB
98.24
65%
-98
- C1 -
3ENK
2
?
A:
[8-340]
--
I
L
V
T
G
G
A
G
Y
I
G
S
H
T
A
V
E
L
L
A
H
G
Y
D
V
V
I
A
D
N
L
V
N
------
S
---
K
---
R
E
A
I
A
R
I
E
K
I
T
G
K
T
P
A
F
H
E
T
D
V
S
D
E
R
A
L
A
R
I
F
-
D
A
-
H
P
I
T
A
A
I
H
F
A
A
L
K
A
V
G
E
S
V
A
K
P
I
E
Y
Y
R
N
N
L
D
S
L
L
S
L
L
R
V
M
R
E
R
A
V
K
R
I
V
F
S
S
S
--------
A
T
V
Y
G
----
V
P
E
R
----
S
---
P
I
D
E
T
F
P
L
-
S
-
A
-
T
N
P
Y
G
Q
T
K
L
M
A
E
Q
I
L
R
D
V
E
A
A
-------------
D
P
-------------
S
-
W
R
V
A
T
L
R
Y
F
N
P
V
G
A
H
E
S
G
L
I
G
E
--
D
P
A
G
I
P
N
N
L
M
P
Y
V
A
Q
V
A
V
G
K
L
E
K
L
R
V
F
G
S
D
Y
P
T
P
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
R
G
H
I
A
A
L
D
A
L
----
E
R
-
R
D
A
S
L
T
V
N
L
G
T
G
R
G
Y
S
V
L
E
V
V
R
A
F
E
K
A
S
G
R
A
V
P
Y
E
L
V
A
R
R
P
G
D
V
A
E
C
Y
A
N
P
A
A
A
A
E
T
I
G
W
K
A
E
R
D
-
L
E
R
---
M
C
A
D
H
W
R
W
Q
E
N
N
P
R
G
F
----
21
PsiBlast_CBE
96.51
65%
-96
- C1 -
3ENK
2
?
B:
[8-340]
--
I
L
V
T
G
G
A
G
Y
I
G
S
H
T
A
V
E
L
L
A
H
G
Y
D
V
V
I
A
D
N
L
V
N
------
S
---
K
---
R
E
A
I
A
R
I
E
K
I
T
G
K
T
P
A
F
H
E
T
D
V
S
D
E
R
A
L
A
R
I
F
-
D
A
-
H
P
I
T
A
A
I
H
F
A
A
L
K
A
V
G
E
S
V
A
K
P
I
E
Y
Y
R
N
N
L
D
S
L
L
S
L
L
R
V
M
R
E
R
A
V
K
R
I
V
F
S
S
S
--------
A
T
V
Y
G
----
V
P
E
R
----
S
---
P
I
D
E
T
F
P
L
-
S
-
A
-
T
N
P
Y
G
Q
T
K
L
M
A
E
Q
I
L
R
D
V
E
A
A
-------------
D
P
-------------
S
-
W
R
V
A
T
L
R
Y
F
N
P
V
G
A
H
E
S
G
L
I
G
E
--
D
P
A
G
I
P
N
N
L
M
P
Y
V
A
Q
V
A
V
G
K
L
E
K
L
R
V
F
G
S
D
Y
P
T
P
D
G
T
G
V
R
D
Y
I
H
V
V
D
L
A
R
G
H
I
A
A
L
D
A
L
----
E
R
-
R
D
A
S
L
T
V
N
L
G
T
G
R
G
Y
S
V
L
E
V
V
R
A
F
E
K
A
S
G
R
A
V
P
Y
E
L
V
A
R
R
P
G
D
V
A
E
C
Y
A
N
P
A
A
A
A
E
T
I
G
W
K
A
E
R
D
-
L
E
R
---
M
C
A
D
H
W
R
W
Q
E
N
N
P
R
G
F
----
30
PsiBlast_CBE
86.20
57%
-45
- C1 -
1KVQ
5
GALE_ECOLI
A:
[1-336]
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
-
H
D
-
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
A
--------
A
T
V
Y
G
----
D
N
P
K
----
I
---
P
Y
V
E
S
F
P
T
-
G
-
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
-------------
Q
P
-------------
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
----
A
N
-
K
P
G
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
-
L
D
E
---
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
----
33
PsiBlast_CBE
85.74
56%
-42
- C1 -
1A9Z
6
GALE_ECOLI
A:
[1-336]
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
-
H
D
-
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
A
--------
A
T
V
Y
G
----
D
N
P
K
----
I
---
P
Y
V
E
S
F
P
T
-
G
-
T
P
Q
S
P
F
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
-------------
Q
P
-------------
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
----
A
N
-
K
P
G
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
-
L
D
E
---
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
----
28
PsiBlast_CBE
85.03
57%
-43
- C1 -
2UDP
2
GALE_ECOLI
B:
[1-336]
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
-
H
D
-
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
--------
A
T
V
Y
G
----
D
Q
P
K
----
I
---
P
Y
V
E
S
F
P
T
-
G
-
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
-------------
Q
P
-------------
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
----
A
N
-
K
P
G
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
-
L
D
E
---
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
----
16
PsiBlast_PDB
85.00
57%
-41
- C1 -
1UDA
7
GALE_ECOLI
A:
[1-336]
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
-
H
D
-
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
--------
A
T
V
Y
G
----
D
N
P
K
----
I
---
P
Y
V
E
S
F
P
T
-
G
-
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
-------------
Q
P
-------------
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
----
A
N
-
K
P
G
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
-
L
D
E
---
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
----
74
HHSearch
84.83
57%
-43
- C1 -
1UDB
7
GALE_ECOLI
A:
[1-335]
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
-
H
D
-
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
--------
A
T
V
Y
G
----
D
N
P
K
----
I
---
P
Y
V
E
S
F
P
T
G
T
-
P
-
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
-------------
Q
P
-------------
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
----
A
N
-
K
P
G
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
-
L
D
E
---
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
-----
29
PsiBlast_CBE
84.77
57%
-45
- C1 -
1KVS
5
GALE_ECOLI
A:
[1-336]
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
-
H
D
-
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
T
--------
A
T
V
Y
G
----
D
N
P
K
----
I
---
P
Y
V
E
S
F
P
T
-
G
-
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
-------------
Q
P
-------------
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
----
A
N
-
K
P
G
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
-
L
D
E
---
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
----
9
PsiBlast_PDB
84.73
57%
-47
- C1 -
1LRK
5
GALE_ECOLI
A:
[1-336]
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
-
H
D
-
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
--------
A
T
V
Y
G
----
D
N
P
K
----
I
---
P
Y
V
E
S
F
P
T
-
G
-
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
-------------
Q
P
-------------
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
----
A
N
-
K
P
G
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
C
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
-
L
D
E
---
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
----
17
PsiBlast_PDB
84.71
57%
-43
- C1 -
1UDB
7
GALE_ECOLI
A:
[1-336]
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
-
H
D
-
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
--------
A
T
V
Y
G
----
D
N
P
K
----
I
---
P
Y
V
E
S
F
P
T
-
G
-
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
-------------
Q
P
-------------
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
----
A
N
-
K
P
G
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
-
L
D
E
---
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
----
14
PsiBlast_PDB
84.64
57%
-44
- C1 -
1NAH
5
GALE_ECOLI
A:
[1-336]
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
-
H
D
-
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
--------
A
T
V
Y
G
----
D
N
P
K
----
I
---
P
Y
V
E
S
F
P
T
-
G
-
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
-------------
Q
P
-------------
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
----
A
N
-
K
P
G
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
-
L
D
E
---
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
----
18
PsiBlast_PDB
84.62
57%
-44
- C1 -
1XEL
6
GALE_ECOLI
A:
[1-336]
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
-
H
D
-
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
--------
A
T
V
Y
G
----
D
N
P
K
----
I
---
P
Y
V
E
S
F
P
T
-
G
-
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
-------------
Q
P
-------------
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
----
A
N
-
K
P
G
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
-
L
D
E
---
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
----
15
PsiBlast_PDB
84.45
57%
-45
- C1 -
1NAI
5
GALE_ECOLI
A:
[1-336]
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
-
H
D
-
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
--------
A
T
V
Y
G
----
D
N
P
K
----
I
---
P
Y
V
E
S
F
P
T
-
G
-
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
-------------
Q
P
-------------
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
----
A
N
-
K
P
G
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
-
L
D
E
---
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
----
11
PsiBlast_PDB
84.25
57%
-43
- C1 -
2UDP
4
GALE_ECOLI
A:
[1-336]
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
-
H
D
-
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
--------
A
T
V
Y
G
----
D
Q
P
K
----
I
---
P
Y
V
E
S
F
P
T
-
G
-
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
-------------
Q
P
-------------
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
----
A
N
-
K
P
G
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
-
L
D
E
---
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
----
10
PsiBlast_PDB
84.25
57%
-44
- C1 -
1LRL
5
GALE_ECOLI
A:
[1-336]
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
-
H
D
-
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
--------
A
T
V
Y
G
----
D
N
P
K
----
I
---
P
Y
V
E
S
F
P
T
-
G
-
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
-------------
Q
P
-------------
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
----
A
N
-
K
P
G
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
C
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
-
L
D
E
---
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
----
31
PsiBlast_CBE
84.16
56%
-45
- C1 -
1A9Y
5
GALE_ECOLI
A:
[1-336]
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
-
H
D
-
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
A
--------
A
T
V
Y
G
----
D
Q
P
K
----
I
---
P
Y
V
E
S
F
P
T
-
G
-
T
P
Q
S
P
F
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
-------------
Q
P
-------------
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
----
A
N
-
K
P
G
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
-
L
D
E
---
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
----
12
PsiBlast_PDB
84.10
57%
-41
- C1 -
1UDC
9
GALE_ECOLI
A:
[1-336]
M
R
V
L
V
T
G
G
S
G
Y
I
G
S
H
T
C
V
Q
L
L
Q
N
G
H
D
V
I
I
L
D
N
L
C
N
------
S
---
K
---
R
S
V
L
P
V
I
E
R
L
G
G
K
H
P
T
F
V
E
G
D
I
R
N
E
A
L
M
T
E
I
L
-
H
D
-
H
A
I
D
T
V
I
H
F
A
G
L
K
A
V
G
E
S
V
Q
K
P
L
E
Y
Y
D
N
N
V
N
G
T
L
R
L
I
S
A
M
R
A
A
N
V
K
N
F
I
F
S
S
S
--------
A
T
V
Y
G
----
D
Q
P
K
----
I
---
P
Y
V
E
S
F
P
T
-
G
-
T
P
Q
S
P
Y
G
K
S
K
L
M
V
E
Q
I
L
T
D
L
Q
K
A
-------------
Q
P
-------------
D
-
W
S
I
A
L
L
R
Y
F
N
P
V
G
A
H
P
S
G
D
M
G
E
--
D
P
Q
G
I
P
N
N
L
M
P
Y
I
A
Q
V
A
V
G
R
R
D
S
L
A
I
F
G
N
D
Y
P
T
E
D
G
T
G
V
R
D
Y
I
H
V
M
D
L
A
D
G
H
V
V
A
M
E
K
L
----
A
N
-
K
P
G
V
H
I
Y
N
L
G
A
G
V
G
N
S
V
L
D
V
V
N
A
F
S
K
A
C
G
K
P
V
N
Y
H
F
A
P
R
R
E
G
D
L
P
A
Y
W
A
D
A
S
K
A
D
R
E
L
N
W
R
V
T
R
T
-
L
D
E
---
M
A
Q
D
T
W
H
W
Q
S
R
H
P
Q
G
Y
----