@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu38970: (2016-08-04 )
MRKQVALVTGAAGGIGFEIAREFAREGASVIVSDLRPEACEKAASKLAEEGFDAAAIPYDVTKEAQVADTVNVIQKQYGRLDILVNNAGIQHVAPIEEFPTDTFEQLIKVMLTAPFIAMKHVFPIMKKQQFGRIINIASVNGLVGFAGKSAYNSAKHGVIGLTKVGALEGAPHGITVNALCPGYVDTQLVRNQLSDLSKTRNVPYDSVLEQVIFPLVPQKRLLSVKEIADYAVFLASEKAKGVTGQAVVLDGGYTAQ
Atome Classification :
(29 SA)
.........10........20........30....-....-40.......-.50.........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
R
K
Q
V
A
L
V
TGAAGG
I
G
F
E
I
A
R
E
F
A
RE
G
A
S
V
I
V
S
DL-
R
P
E
A
-
C
E
K
A
A
S
K
L
A
-
E
E-GFDAAAIPYDVTKE
A
Q
V
A
D
T
V
N
V
I
Q
K
QYG
R
L
D
I
L
V
NNAGIQHVA
P
I
E
EFP
T
D
T
F
E
Q
L
I
K
V
M
LT
A
P
F
I
A
M
K
H
V
F
P
I
M
K
K
Q
QFG
R
I
I
N
I
A
SVNGLVGFAGKSAYNSAKHG
V
I
G
L
T
K
VGALEGAPH
G
I
T
V
NALCPG
Y
V
D
T
Q
L
V
R
N
Q
L
S
D
L
S
K
TRNV
P
Y
D
S
V
L
E
Q
V
I
F
PLV
P
Q
K
R
L
L
S
V
K
E
I
A
D
Y
A
V
F
LASEKAKGVTG
Q
A
V
V
LDGGYTAQ
48
PsiBlast_CBE
88.36
40%
-115
- C1 -
2Q2V
1
?
C:
[2-255]
L
K
G
K
T
A
L
V
T
G
S
T
S
G
I
G
L
G
I
A
Q
V
L
A
R
A
G
A
N
I
V
L
N
G
F
-
G
D
P
A
---
P
A
L
A
E
I
A
-
R
H
-
G
V
K
A
V
H
H
P
A
D
L
S
D
V
A
Q
I
E
A
L
F
A
L
A
E
R
E
F
G
G
V
D
I
L
V
N
N
A
G
I
Q
H
V
A
P
V
E
Q
F
P
L
E
S
W
D
K
I
I
A
L
N
L
S
A
V
F
H
G
T
R
L
A
L
P
G
M
R
A
R
N
W
G
R
I
I
N
I
A
S
V
H
G
L
V
G
S
T
G
K
A
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
V
G
L
E
T
A
T
S
N
V
T
C
N
A
I
C
P
G
W
V
L
T
P
L
V
Q
K
Q
I
D
D
R
-------
L
Q
A
-
Q
H
D
L
L
A
E
K
Q
P
S
L
A
F
V
T
P
E
H
L
G
E
L
V
L
F
L
C
S
E
A
G
S
Q
V
R
G
A
A
W
N
V
D
G
G
W
L
A
Q
49
PsiBlast_CBE
87.78
40%
-110
- C1 -
2Q2V
1
?
B:
[2-255]
L
K
G
K
T
A
L
V
T
G
S
T
S
G
I
G
L
G
I
A
Q
V
L
A
R
A
G
A
N
I
V
L
N
G
F
-
G
D
P
A
---
P
A
L
A
E
I
A
-
R
H
-
G
V
K
A
V
H
H
P
A
D
L
S
D
V
A
Q
I
E
A
L
F
A
L
A
E
R
E
F
G
G
V
D
I
L
V
N
N
A
G
I
Q
H
V
A
P
V
E
Q
F
P
L
E
S
W
D
K
I
I
A
L
N
L
S
A
V
F
H
G
T
R
L
A
L
P
G
M
R
A
R
N
W
G
R
I
I
N
I
A
S
V
H
G
L
V
G
S
T
G
K
A
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
V
G
L
E
T
A
T
S
N
V
T
C
N
A
I
C
P
G
W
V
L
T
P
L
V
Q
K
Q
I
D
D
R
A
A
--
G
D
P
L
Q
A
-
Q
H
D
L
L
A
E
K
Q
P
S
L
A
F
V
T
P
E
H
L
G
E
L
V
L
F
L
C
S
E
A
G
S
Q
V
R
G
A
A
W
N
V
D
G
G
W
L
A
Q
51
PsiBlast_CBE
86.63
40%
-113
- C1 -
2Q2Q
1
?
G:
[2-255]
L
K
G
K
T
A
L
V
T
G
S
T
S
G
I
G
L
G
I
A
Q
V
L
A
R
A
G
A
N
I
V
L
N
G
F
-
G
D
P
A
---
P
A
L
A
E
I
A
-
R
H
-
G
V
K
A
V
H
H
P
A
D
L
S
D
V
A
Q
I
E
A
L
F
A
L
A
E
R
E
F
G
G
V
D
I
L
V
N
N
A
G
I
Q
H
V
A
P
V
E
Q
F
P
L
E
S
W
D
K
I
I
A
L
N
L
S
A
V
F
H
G
T
R
L
A
L
P
G
M
R
A
R
N
W
G
R
I
I
N
I
A
S
V
H
G
L
V
G
S
T
G
K
A
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
V
G
L
E
T
A
T
S
N
V
T
C
N
A
I
C
P
G
W
V
L
T
P
L
V
Q
K
Q
I
D
D
R
A
A
----
P
L
Q
A
-
Q
H
D
L
L
A
E
K
Q
P
S
L
A
F
V
T
P
E
H
L
G
E
L
V
L
F
L
C
S
E
A
G
S
Q
V
R
G
A
A
W
N
V
D
G
G
W
L
A
Q
53
PsiBlast_CBE
85.51
40%
-113
- C1 -
2Q2Q
1
?
E:
[2-255]
L
K
G
K
T
A
L
V
T
G
S
T
S
G
I
G
L
G
I
A
Q
V
L
A
R
A
G
A
N
I
V
L
N
G
F
-
G
D
P
A
---
P
A
L
A
E
I
A
-
R
H
-
G
V
K
A
V
H
H
P
A
D
L
S
D
V
A
Q
I
E
A
L
F
A
L
A
E
R
E
F
G
G
V
D
I
L
V
N
N
A
G
I
Q
H
V
A
P
V
E
Q
F
P
L
E
S
W
D
K
I
I
A
L
N
L
S
A
V
F
H
G
T
R
L
A
L
P
G
M
R
A
R
N
W
G
R
I
I
N
I
A
S
V
H
G
L
V
G
S
T
G
K
A
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
V
G
L
E
T
A
T
S
N
V
T
C
N
A
I
C
P
G
W
V
L
T
P
L
V
Q
K
Q
I
D
D
R
A
------
L
Q
A
-
Q
H
D
L
L
A
E
K
Q
P
S
L
A
F
V
T
P
E
H
L
G
E
L
V
L
F
L
C
S
E
A
G
S
Q
V
R
G
A
A
W
N
V
D
G
G
W
L
A
Q
16
PsiBlast_PDB
85.43
40%
-120
- C1 -
2Q2W
-
?
A:
[3-256]
L
K
G
K
T
A
L
V
T
G
S
T
S
G
I
G
L
G
I
A
Q
V
L
A
R
A
G
A
N
I
V
L
N
G
F
-
G
D
P
A
---
P
A
L
A
E
I
A
-
R
H
-
G
V
K
A
V
H
H
P
A
D
L
S
D
V
A
Q
I
E
A
L
F
A
L
A
E
R
E
F
G
G
V
D
I
L
V
N
N
A
G
I
Q
H
V
A
P
V
E
Q
F
P
L
E
S
W
D
K
I
I
A
L
N
L
S
A
V
F
H
G
T
R
L
A
L
P
G
M
R
A
R
N
W
G
R
I
I
N
I
A
S
V
H
G
L
V
G
S
T
G
K
A
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
V
G
L
E
T
A
T
S
N
V
T
C
N
A
I
C
P
G
W
V
L
T
P
L
V
Q
K
Q
I
D
D
R
--
N
G
G
D
P
L
Q
A
-
Q
H
D
L
L
A
E
K
Q
P
S
L
A
F
V
T
P
E
H
L
G
E
L
V
L
F
L
C
S
E
A
G
S
Q
V
R
G
A
A
W
N
V
D
G
G
W
L
A
Q
14
PsiBlast_PDB
84.55
40%
-118
- C1 -
2Q2Q
1
?
A:
[2-255]
L
K
G
K
T
A
L
V
T
G
S
T
S
G
I
G
L
G
I
A
Q
V
L
A
R
A
G
A
N
I
V
L
N
G
F
-
G
D
P
A
---
P
A
L
A
E
I
A
-
R
H
-
G
V
K
A
V
H
H
P
A
D
L
S
D
V
A
Q
I
E
A
L
F
A
L
A
E
R
E
F
G
G
V
D
I
L
V
N
N
A
G
I
Q
H
V
A
P
V
E
Q
F
P
L
E
S
W
D
K
I
I
A
L
N
L
S
A
V
F
H
G
T
R
L
A
L
P
G
M
R
A
R
N
W
G
R
I
I
N
I
A
S
V
H
G
L
V
G
S
T
G
K
A
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
V
G
L
E
T
A
T
S
N
V
T
C
N
A
I
C
P
G
W
V
L
T
P
L
V
Q
K
Q
I
D
D
R
-----
D
P
L
Q
A
-
Q
H
D
L
L
A
E
K
Q
P
S
L
A
F
V
T
P
E
H
L
G
E
L
V
L
F
L
C
S
E
A
G
S
Q
V
R
G
A
A
W
N
V
D
G
G
W
L
A
Q
47
PsiBlast_CBE
83.77
40%
-117
- C1 -
2Q2V
1
?
D:
[2-255]
L
K
G
K
T
A
L
V
T
G
S
T
S
G
I
G
L
G
I
A
Q
V
L
A
R
A
G
A
N
I
V
L
N
G
F
-
G
D
P
A
---
P
A
L
A
E
I
A
-
R
H
-
G
V
K
A
V
H
H
P
A
D
L
S
D
V
A
Q
I
E
A
L
F
A
L
A
E
R
E
F
G
G
V
D
I
L
V
N
N
A
G
I
Q
H
V
A
P
V
E
Q
F
P
L
E
S
W
D
K
I
I
A
L
N
L
S
A
V
F
H
G
T
R
L
A
L
P
G
M
R
A
R
N
W
G
R
I
I
N
I
A
S
V
H
G
L
V
G
S
T
G
K
A
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
V
G
L
E
T
A
T
S
N
V
T
C
N
A
I
C
P
G
W
V
L
T
P
L
V
Q
K
Q
I
D
D
R
--------
Q
A
-
Q
H
D
L
L
A
E
K
Q
P
S
L
A
F
V
T
P
E
H
L
G
E
L
V
L
F
L
C
S
E
A
G
S
Q
V
R
G
A
A
W
N
V
D
G
G
W
L
A
Q
54
PsiBlast_CBE
83.58
40%
-110
- C1 -
2Q2Q
1
?
D:
[2-255]
L
K
G
K
T
A
L
V
T
G
S
T
S
G
I
G
L
G
I
A
Q
V
L
A
R
A
G
A
N
I
V
L
N
G
F
-
G
D
P
A
---
P
A
L
A
E
I
A
-
R
H
-
G
V
K
A
V
H
H
P
A
D
L
S
D
V
A
Q
I
E
A
L
F
A
L
A
E
R
E
F
G
G
V
D
I
L
V
N
N
A
G
I
Q
H
V
A
P
V
E
Q
F
P
L
E
S
W
D
K
I
I
A
L
N
L
S
A
V
F
H
G
T
R
L
A
L
P
G
M
R
A
R
N
W
G
R
I
I
N
I
A
S
V
H
G
L
V
G
S
T
G
K
A
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
V
G
L
E
T
A
T
S
N
V
T
C
N
A
I
C
P
G
W
V
L
T
P
L
V
Q
K
Q
I
D
D
R
A
A
N
G
G
D
P
L
Q
A
-
Q
H
D
L
L
A
E
K
Q
P
S
L
A
F
V
T
P
E
H
L
G
E
L
V
L
F
L
C
S
E
A
G
S
Q
V
R
G
A
A
W
N
V
D
G
G
W
L
A
Q
3
PsiBlast_PDB
83.55
42%
-26
- C1 -
3VDQ
4
?
A:
[2-260]
L
K
G
K
K
A
V
V
T
G
S
T
S
G
I
G
L
A
M
A
T
E
L
A
K
A
G
A
D
V
V
I
N
G
F
G
Q
P
E
D
-
I
E
R
E
R
S
T
L
E
-
S
K
F
G
V
K
A
Y
Y
L
N
A
D
L
S
D
A
Q
A
T
R
D
F
I
A
K
A
A
E
A
L
G
G
L
D
I
L
V
N
N
A
G
I
Q
H
T
A
P
I
E
E
F
P
V
D
K
W
N
A
I
I
A
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
I
M
Q
K
Q
G
W
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
V
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
T
A
L
E
N
A
G
K
G
I
T
C
N
A
I
C
P
G
W
V
R
T
P
L
V
E
K
Q
I
E
A
I
S
Q
Q
K
G
I
D
I
E
A
A
A
R
E
L
L
A
E
K
Q
P
S
L
Q
F
V
T
P
E
Q
L
G
G
A
A
V
F
L
S
S
A
A
A
D
Q
M
T
G
T
T
L
S
L
D
G
G
W
T
A
R
55
PsiBlast_CBE
83.54
40%
-122
- C1 -
2Q2Q
1
?
C:
[2-255]
L
K
G
K
T
A
L
V
T
G
S
T
S
G
I
G
L
G
I
A
Q
V
L
A
R
A
G
A
N
I
V
L
N
G
F
-
G
D
P
A
---
P
A
L
A
E
I
A
-
R
H
-
G
V
K
A
V
H
H
P
A
D
L
S
D
V
A
Q
I
E
A
L
F
A
L
A
E
R
E
F
G
G
V
D
I
L
V
N
N
A
G
I
Q
H
V
A
P
V
E
Q
F
P
L
E
S
W
D
K
I
I
A
L
N
L
S
A
V
F
H
G
T
R
L
A
L
P
G
M
R
A
R
N
W
G
R
I
I
N
I
A
S
V
H
G
L
V
G
S
T
G
K
A
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
V
G
L
E
T
A
T
S
N
V
T
C
N
A
I
C
P
G
W
V
L
T
P
L
V
Q
K
Q
I
------------
A
-
Q
H
D
L
L
A
E
K
Q
P
S
L
A
F
V
T
P
E
H
L
G
E
L
V
L
F
L
C
S
E
A
G
S
Q
V
R
G
A
A
W
N
V
D
G
G
W
L
A
Q
15
PsiBlast_PDB
83.13
40%
-117
- C1 -
2Q2V
-
?
A:
[2-255]
L
K
G
K
T
A
L
V
T
G
S
T
S
G
I
G
L
G
I
A
Q
V
L
A
R
A
G
A
N
I
V
L
N
G
F
-
G
D
P
A
---
P
A
L
A
E
I
A
-
R
H
-
G
V
K
A
V
H
H
P
A
D
L
S
D
V
A
Q
I
E
A
L
F
A
L
A
E
R
E
F
G
G
V
D
I
L
V
N
N
A
G
I
Q
H
V
A
P
V
E
Q
F
P
L
E
S
W
D
K
I
I
A
L
N
L
S
A
V
F
H
G
T
R
L
A
L
P
G
M
R
A
R
N
W
G
R
I
I
N
I
A
S
V
H
G
L
V
G
S
T
G
K
A
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
V
G
L
E
T
A
T
S
N
V
T
C
N
A
I
C
P
G
W
V
L
T
P
L
V
Q
K
Q
I
D
D
R
A
A
N
G
G
D
P
L
Q
A
-
Q
H
D
L
L
A
E
K
Q
P
S
L
A
F
V
T
P
E
H
L
G
E
L
V
L
F
L
C
S
E
A
G
S
Q
V
R
G
A
A
W
N
V
D
G
G
W
L
A
Q
6
PsiBlast_PDB
82.52
42%
-25
- C1 -
3W8F
3
?
A:
[2-260]
L
K
G
K
K
A
V
V
T
G
S
T
S
G
I
G
L
A
M
A
T
E
L
A
K
A
G
A
D
V
V
I
N
G
F
G
Q
P
E
D
-
I
E
R
E
R
S
T
L
E
-
S
K
F
G
V
K
A
Y
Y
L
N
A
D
L
S
D
A
Q
A
T
R
D
F
I
A
K
A
A
E
A
L
G
G
L
D
I
L
V
N
N
A
G
I
Q
H
T
A
P
I
E
E
F
P
V
D
K
W
N
A
I
I
A
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
I
M
Q
K
Q
G
W
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
V
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
T
A
L
E
N
A
G
K
G
I
T
C
N
A
I
C
P
G
W
V
R
T
P
L
V
E
K
Q
I
E
A
I
S
Q
Q
K
G
I
D
I
E
A
A
A
R
E
L
L
A
E
K
Q
P
S
L
Q
F
V
T
P
E
Q
L
G
G
A
A
V
F
L
S
S
A
A
A
D
Q
M
T
G
T
T
L
S
L
D
G
G
W
T
A
R
50
PsiBlast_CBE
82.05
40%
-116
- C1 -
2Q2Q
1
?
H:
[2-255]
L
K
G
K
T
A
L
V
T
G
S
T
S
G
I
G
L
G
I
A
Q
V
L
A
R
A
G
A
N
I
V
L
N
G
F
-
G
D
P
A
---
P
A
L
A
E
I
A
-
R
H
-
G
V
K
A
V
H
H
P
A
D
L
S
D
V
A
Q
I
E
A
L
F
A
L
A
E
R
E
F
G
G
V
D
I
L
V
N
N
A
G
I
Q
H
V
A
P
V
E
Q
F
P
L
E
S
W
D
K
I
I
A
L
N
L
S
A
V
F
H
G
T
R
L
A
L
P
G
M
R
A
R
N
W
G
R
I
I
N
I
A
S
V
H
G
L
V
G
S
T
G
K
A
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
V
G
L
E
T
A
T
S
N
V
T
C
N
A
I
C
P
G
W
V
L
T
P
---------------
P
L
Q
A
-
Q
H
D
L
L
A
E
K
Q
P
S
L
A
F
V
T
P
E
H
L
G
E
L
V
L
F
L
C
S
E
A
G
S
Q
V
R
G
A
A
W
N
V
D
G
G
W
L
A
Q
1
PsiBlast_PDB
81.98
42%
-32
- C1 -
2YZ7
2
?
A:
[2-260]
L
K
G
K
K
A
V
V
T
G
S
T
S
G
I
G
L
A
M
A
T
E
L
A
K
A
G
A
D
V
V
I
N
G
F
G
Q
P
E
D
-
I
E
R
E
R
S
T
L
E
-
S
K
F
G
V
K
A
Y
Y
L
N
A
D
L
S
D
A
Q
A
T
R
D
F
I
A
K
A
A
E
A
L
G
G
L
D
I
L
V
N
N
A
G
I
Q
H
T
A
P
I
E
E
F
P
V
D
K
W
N
A
I
I
A
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
I
M
Q
K
Q
G
W
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
V
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
T
A
L
E
N
A
G
K
G
I
T
C
N
A
I
C
P
G
W
V
R
T
P
L
V
E
K
Q
I
E
A
I
S
Q
Q
K
G
I
D
I
E
A
A
A
R
E
L
L
A
E
K
Q
P
S
L
Q
F
V
T
P
E
Q
L
G
G
A
A
V
F
L
S
S
A
A
A
D
Q
M
T
G
T
T
L
S
L
D
G
G
W
T
A
R
35
PsiBlast_CBE
81.87
43%
-25
- C1 -
2ZTV
2
?
C:
[2-260]
L
K
G
K
V
A
V
V
T
G
S
T
S
G
I
G
L
G
I
A
T
A
L
A
A
Q
G
A
D
I
V
L
N
G
F
-
G
D
A
A
E
I
E
K
V
R
A
G
L
A
A
Q
H
-
G
V
K
V
L
Y
D
G
A
D
L
S
K
G
E
A
V
R
G
L
V
D
N
A
V
R
Q
M
G
R
I
D
I
L
V
N
N
A
G
I
Q
H
T
A
L
I
E
D
F
P
T
E
K
W
D
A
I
L
A
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
H
M
K
K
Q
G
F
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
A
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
F
T
K
V
T
A
L
E
T
A
G
Q
G
I
T
A
N
A
I
C
P
G
W
V
R
T
P
L
V
E
K
Q
I
S
A
-----
G
V
D
Q
E
T
A
A
R
E
L
L
S
E
K
Q
P
S
L
Q
F
V
T
P
E
Q
L
G
G
T
A
V
F
L
A
S
D
A
A
A
Q
I
T
G
T
T
V
S
V
D
G
G
W
T
A
R
33
PsiBlast_CBE
81.55
42%
-28
- C1 -
2YZ7
2
?
B:
[2-260]
L
K
G
K
K
A
V
V
T
G
S
T
S
G
I
G
L
A
M
A
T
E
L
A
K
A
G
A
D
V
V
I
N
G
F
G
Q
P
E
D
-
I
E
R
E
R
S
T
L
E
-
S
K
F
G
V
K
A
Y
Y
L
N
A
D
L
S
D
A
Q
A
T
R
D
F
I
A
K
A
A
E
A
L
G
G
L
D
I
L
V
N
N
A
G
I
Q
H
T
A
P
I
E
E
F
P
V
D
K
W
N
A
I
I
A
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
I
M
Q
K
Q
G
W
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
V
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
T
A
L
E
N
A
G
K
G
I
T
C
N
A
I
C
P
G
W
V
R
T
P
L
V
E
K
Q
I
E
A
I
S
Q
Q
K
G
I
D
I
E
A
A
A
R
E
L
L
A
E
K
Q
P
S
L
Q
F
V
T
P
E
Q
L
G
G
A
A
V
F
L
S
S
A
A
A
D
Q
M
T
G
T
T
L
S
L
D
G
G
W
T
A
R
25
PsiBlast_CBE
81.36
42%
-31
- C1 -
3VDQ
4
?
C:
[2-260]
L
K
G
K
K
A
V
V
T
G
S
T
S
G
I
G
L
A
M
A
T
E
L
A
K
A
G
A
D
V
V
I
N
G
F
G
Q
P
E
D
-
I
E
R
E
R
S
T
L
E
-
S
K
F
G
V
K
A
Y
Y
L
N
A
D
L
S
D
A
Q
A
T
R
D
F
I
A
K
A
A
E
A
L
G
G
L
D
I
L
V
N
N
A
G
I
Q
H
T
A
P
I
E
E
F
P
V
D
K
W
N
A
I
I
A
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
I
M
Q
K
Q
G
W
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
V
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
T
A
L
E
N
A
G
K
G
I
T
C
N
A
I
C
P
G
W
V
R
T
P
L
V
E
K
Q
I
E
A
I
S
Q
Q
K
G
I
D
I
E
A
A
A
R
E
L
L
A
E
K
Q
P
S
L
Q
F
V
T
P
E
Q
L
G
G
A
A
V
F
L
S
S
A
A
A
D
Q
M
T
G
T
T
L
S
L
D
G
G
W
T
A
R
2
PsiBlast_PDB
81.02
42%
-22
- C1 -
3VDR
4
?
A:
[2-260]
L
K
G
K
K
A
V
V
T
G
S
T
S
G
I
G
L
A
M
A
T
E
L
A
K
A
G
A
D
V
V
I
N
G
F
G
Q
P
E
D
-
I
E
R
E
R
S
T
L
E
-
S
K
F
G
V
K
A
Y
Y
L
N
A
D
L
S
D
A
Q
A
T
R
D
F
I
A
K
A
A
E
A
L
G
G
L
D
I
L
V
N
N
A
G
I
Q
H
T
A
P
I
E
E
F
P
V
D
K
W
N
A
I
I
A
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
I
M
Q
K
Q
G
W
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
V
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
T
A
L
E
N
A
G
K
G
I
T
C
N
A
I
C
P
G
W
V
R
T
P
L
V
E
K
Q
I
E
A
I
S
Q
Q
K
G
I
D
I
E
A
A
A
R
E
L
L
A
E
K
Q
P
S
L
Q
F
V
T
P
E
Q
L
G
G
A
A
V
F
L
S
S
A
A
A
D
Q
M
T
G
T
T
L
S
L
D
G
G
W
T
A
R
32
PsiBlast_CBE
81.00
42%
-34
- C1 -
2YZ7
2
?
C:
[2-260]
L
K
G
K
K
A
V
V
T
G
S
T
S
G
I
G
L
A
M
A
T
E
L
A
K
A
G
A
D
V
V
I
N
G
F
G
Q
P
E
D
-
I
E
R
E
R
S
T
L
E
-
S
K
F
G
V
K
A
Y
Y
L
N
A
D
L
S
D
A
Q
A
T
R
D
F
I
A
K
A
A
E
A
L
G
G
L
D
I
L
V
N
N
A
G
I
Q
H
T
A
P
I
E
E
F
P
V
D
K
W
N
A
I
I
A
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
I
M
Q
K
Q
G
W
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
V
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
T
A
L
E
N
A
G
K
G
I
T
C
N
A
I
C
P
G
W
V
R
T
P
L
V
E
K
Q
I
E
A
I
S
Q
Q
K
G
I
D
I
E
A
A
A
R
E
L
L
A
E
K
Q
P
S
L
Q
F
V
T
P
E
Q
L
G
G
A
A
V
F
L
S
S
A
A
A
D
Q
M
T
G
T
T
L
S
L
D
G
G
W
T
A
R
37
PsiBlast_CBE
80.88
43%
-20
- C1 -
2ZTL
4
?
D:
[2-260]
L
K
G
K
V
A
V
V
T
G
S
T
S
G
I
G
L
G
I
A
T
A
L
A
A
Q
G
A
D
I
V
L
N
G
F
-
G
D
A
A
E
I
E
K
V
R
A
G
L
A
A
Q
H
-
G
V
K
V
L
Y
D
G
A
D
L
S
K
G
E
A
V
R
G
L
V
D
N
A
V
R
Q
M
G
R
I
D
I
L
V
N
N
A
G
I
Q
H
T
A
L
I
E
D
F
P
T
E
K
W
D
A
I
L
A
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
H
M
K
K
Q
G
F
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
A
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
F
T
K
V
T
A
L
E
T
A
G
Q
G
I
T
A
N
A
I
C
P
G
W
V
R
T
P
L
V
E
K
Q
I
S
A
L
A
E
K
N
G
V
D
Q
E
T
A
A
R
E
L
L
S
E
K
Q
P
S
L
Q
F
V
T
P
E
Q
L
G
G
T
A
V
F
L
A
S
D
A
A
A
Q
I
T
G
T
T
V
S
V
D
G
G
W
T
A
R
9
PsiBlast_PDB
80.78
43%
-19
- C1 -
2ZTL
3
?
A:
[2-260]
L
K
G
K
V
A
V
V
T
G
S
T
S
G
I
G
L
G
I
A
T
A
L
A
A
Q
G
A
D
I
V
L
N
G
F
-
G
D
A
A
E
I
E
K
V
R
A
G
L
A
A
Q
H
-
G
V
K
V
L
Y
D
G
A
D
L
S
K
G
E
A
V
R
G
L
V
D
N
A
V
R
Q
M
G
R
I
D
I
L
V
N
N
A
G
I
Q
H
T
A
L
I
E
D
F
P
T
E
K
W
D
A
I
L
A
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
H
M
K
K
Q
G
F
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
A
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
F
T
K
V
T
A
L
E
T
A
G
Q
G
I
T
A
N
A
I
C
P
G
W
V
R
T
P
L
V
E
K
Q
I
S
A
L
A
E
K
N
G
V
D
Q
E
T
A
A
R
E
L
L
S
E
K
Q
P
S
L
Q
F
V
T
P
E
Q
L
G
G
T
A
V
F
L
A
S
D
A
A
A
Q
I
T
G
T
T
V
S
V
D
G
G
W
T
A
R
21
PsiBlast_CBE
80.69
42%
-24
- C1 -
3VDR
4
?
D:
[2-260]
L
K
G
K
K
A
V
V
T
G
S
T
S
G
I
G
L
A
M
A
T
E
L
A
K
A
G
A
D
V
V
I
N
G
F
G
Q
P
E
D
-
I
E
R
E
R
S
T
L
E
-
S
K
F
G
V
K
A
Y
Y
L
N
A
D
L
S
D
A
Q
A
T
R
D
F
I
A
K
A
A
E
A
L
G
G
L
D
I
L
V
N
N
A
G
I
Q
H
T
A
P
I
E
E
F
P
V
D
K
W
N
A
I
I
A
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
I
M
Q
K
Q
G
W
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
V
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
T
A
L
E
N
A
G
K
G
I
T
C
N
A
I
C
P
G
W
V
R
T
P
L
V
E
K
Q
I
E
A
I
S
Q
Q
K
G
I
D
I
E
A
A
A
R
E
L
L
A
E
K
Q
P
S
L
Q
F
V
T
P
E
Q
L
G
G
A
A
V
F
L
S
S
A
A
A
D
Q
M
T
G
T
T
L
S
L
D
G
G
W
T
A
R
39
PsiBlast_CBE
80.63
43%
-21
- C1 -
2ZTL
3
?
B:
[2-260]
L
K
G
K
V
A
V
V
T
G
S
T
S
G
I
G
L
G
I
A
T
A
L
A
A
Q
G
A
D
I
V
L
N
G
F
-
G
D
A
A
E
I
E
K
V
R
A
G
L
A
A
Q
H
-
G
V
K
V
L
Y
D
G
A
D
L
S
K
G
E
A
V
R
G
L
V
D
N
A
V
R
Q
M
G
R
I
D
I
L
V
N
N
A
G
I
Q
H
T
A
L
I
E
D
F
P
T
E
K
W
D
A
I
L
A
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
H
M
K
K
Q
G
F
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
A
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
F
T
K
V
T
A
L
E
T
A
G
Q
G
I
T
A
N
A
I
C
P
G
W
V
R
T
P
L
V
E
K
Q
I
S
A
L
A
E
K
N
G
V
D
Q
E
T
A
A
R
E
L
L
S
E
K
Q
P
S
L
Q
F
V
T
P
E
Q
L
G
G
T
A
V
F
L
A
S
D
A
A
A
Q
I
T
G
T
T
V
S
V
D
G
G
W
T
A
R
38
PsiBlast_CBE
80.49
43%
-22
- C1 -
2ZTL
3
?
C:
[2-260]
L
K
G
K
V
A
V
V
T
G
S
T
S
G
I
G
L
G
I
A
T
A
L
A
A
Q
G
A
D
I
V
L
N
G
F
-
G
D
A
A
E
I
E
K
V
R
A
G
L
A
A
Q
H
-
G
V
K
V
L
Y
D
G
A
D
L
S
K
G
E
A
V
R
G
L
V
D
N
A
V
R
Q
M
G
R
I
D
I
L
V
N
N
A
G
I
Q
H
T
A
L
I
E
D
F
P
T
E
K
W
D
A
I
L
A
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
H
M
K
K
Q
G
F
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
A
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
F
T
K
V
T
A
L
E
T
A
G
Q
G
I
T
A
N
A
I
C
P
G
W
V
R
T
P
L
V
E
K
Q
I
S
A
L
A
E
K
N
G
V
D
Q
E
T
A
A
R
E
L
L
S
E
K
Q
P
S
L
Q
F
V
T
P
E
Q
L
G
G
T
A
V
F
L
A
S
D
A
A
A
Q
I
T
G
T
T
V
S
V
D
G
G
W
T
A
R
4
PsiBlast_PDB
80.37
42%
-27
- C1 -
3W8D
6
?
A:
[2-260]
L
K
G
K
K
A
V
V
T
G
S
T
S
G
I
G
L
A
M
A
T
E
L
A
K
A
G
A
D
V
V
I
N
G
F
G
Q
P
E
D
-
I
E
R
E
R
S
T
L
E
-
S
K
F
G
V
K
A
Y
Y
L
N
A
D
L
S
D
A
Q
A
T
R
D
F
I
A
K
A
A
E
A
L
G
G
L
D
I
L
V
N
N
A
G
I
Q
H
T
A
P
I
E
E
F
P
V
D
K
W
N
A
I
I
A
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
I
M
Q
K
Q
G
W
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
V
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
T
A
L
E
N
A
G
K
G
I
T
C
N
A
I
C
P
G
W
V
R
T
P
L
V
E
K
Q
I
E
A
I
S
Q
Q
K
G
I
D
I
E
A
A
A
R
E
L
L
A
E
K
Q
P
S
L
Q
F
V
T
P
E
Q
L
G
G
A
A
V
F
L
S
S
A
A
A
D
Q
M
T
G
T
T
L
S
L
D
G
G
W
T
A
R
5
PsiBlast_PDB
80.36
42%
-26
- C1 -
3W8E
3
?
A:
[2-260]
L
K
G
K
K
A
V
V
T
G
S
T
S
G
I
G
L
A
M
A
T
E
L
A
K
A
G
A
D
V
V
I
N
G
F
G
Q
P
E
D
-
I
E
R
E
R
S
T
L
E
-
S
K
F
G
V
K
A
Y
Y
L
N
A
D
L
S
D
A
Q
A
T
R
D
F
I
A
K
A
A
E
A
L
G
G
L
D
I
L
V
N
N
A
G
I
Q
H
T
A
P
I
E
E
F
P
V
D
K
W
N
A
I
I
A
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
I
M
Q
K
Q
G
W
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
V
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
T
A
L
E
N
A
G
K
G
I
T
C
N
A
I
C
P
G
W
V
R
T
P
L
V
E
K
Q
I
E
A
I
S
Q
Q
K
G
I
D
I
E
A
A
A
R
E
L
L
A
E
K
Q
P
S
L
Q
F
V
T
P
E
Q
L
G
G
A
A
V
F
L
S
S
A
A
A
D
Q
M
T
G
T
T
L
S
L
D
G
G
W
T
A
R
22
PsiBlast_CBE
79.01
42%
-22
- C1 -
3VDR
3
?
C:
[2-260]
L
K
G
K
K
A
V
V
T
G
S
T
S
G
I
G
L
A
M
A
T
E
L
A
K
A
G
A
D
V
V
I
N
G
F
G
Q
P
E
D
-
I
E
R
E
R
S
T
L
E
-
S
K
F
G
V
K
A
Y
Y
L
N
A
D
L
S
D
A
Q
A
T
R
D
F
I
A
K
A
A
E
A
L
G
G
L
D
I
L
V
N
N
A
G
I
Q
H
T
A
P
I
E
E
F
P
V
D
K
W
N
A
I
I
A
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
I
M
Q
K
Q
G
W
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
V
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
L
T
K
V
T
A
L
E
N
A
G
K
G
I
T
C
N
A
I
C
P
G
W
V
R
T
P
L
V
E
K
Q
I
E
A
I
S
Q
Q
K
G
I
D
I
E
A
A
A
R
E
L
L
A
E
K
Q
P
S
L
Q
F
V
T
P
E
Q
L
G
G
A
A
V
F
L
S
S
A
A
A
D
Q
M
T
G
T
T
L
S
L
D
G
G
W
T
A
R
12
PsiBlast_PDB
78.26
43%
-19
- C1 -
2ZTM
3
?
A:
[6-260]
----
V
A
V
V
T
G
S
T
S
G
I
G
L
G
I
A
T
A
L
A
A
Q
G
A
D
I
V
L
N
G
F
-
G
D
A
A
E
I
E
K
V
R
A
G
L
A
A
Q
H
-
G
V
K
V
L
Y
D
G
A
D
L
S
K
G
E
A
V
R
G
L
V
D
N
A
V
R
Q
M
G
R
I
D
I
L
V
N
N
A
G
I
Q
H
T
A
L
I
E
D
F
P
T
E
K
W
D
A
I
L
A
L
N
L
S
A
V
F
H
G
T
A
A
A
L
P
H
M
K
K
Q
G
F
G
R
I
I
N
I
A
S
A
H
G
L
V
A
S
A
N
K
S
A
Y
V
A
A
K
H
G
V
V
G
F
T
K
V
T
A
L
E
T
A
G
Q
G
I
T
A
N
A
I
C
P
G
W
V
R
S
P
L
V
E
K
Q
I
S
A
L
A
E
K
N
G
V
D
Q
E
T
A
A
R
E
L
L
S
E
K
Q
P
S
L
Q
F
V
T
P
E
Q
L
G
G
T
A
V
F
L
A
S
D
A
A
A
Q
I
T
G
T
T
V
S
V
D
G
G
W
T
A
R
23
PsiBlast_CBE
77.35
42%
-27
- C1 -
3VDR
4
?
B:
[2-260]
L
K
G
K
K
A
V
V
T
G
S
T
S
G
I
G
L
A
M
A
T
E
L
A
K
A
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