@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu39780: (2016-08-06 )
MKKAKLGKSDLQVFPIGLGTNAVGGHNLYPNLNEETGKELVREAIRNGVTMLDTAYIYGIGRSEELIGEVLREFNREDVVIATKAAHRKQGNDFVFDNSPDFLKKSVDESLKRLNTDYIDLFYIHFPDEHTPKDEAVNALNEMKKAGKIRSIGVSNFSLEQLKEANKDGLVDVLQGEYNLLNREAEKTFFPYTKEHNISFIPYFPLVSGLLAGKYTEDTTFPEGDLRNEQEHFKGERFKENIRKVNKLAPIAEKHNVDIPHIVLAWYLARPEIDILIPGAKRADQLIDNIKTADVTLSQEDISFIDKLFA
Atome Classification :
(22 SA)
.........10........20........30........40........50........60------.........70..--.---...--.-.80...--....-.90.-----.---.----..-.-...100.......110.......120.......130---------------.-........140.......150......----.160..----...----.----.--170--...--.....180...-....190........200.......210.......220.---.....---..230-.----.......-.-240.......250.-..--....260.........270.......280.......290..-.--.--...300.......310
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKKAKLGKSD
L
Q
V
F
P
I
GLGTNAVGGHNLYPNL
N
E
E
T
G
K
E
L
V
R
E
A
I
RNG
V
T
ML
D
T
A
Y
I
YGI-------G
R
S
E
E
L
I
G
E
V
L
R
E--F---NRE--
D
-
V
V
I
A
TK--AAHR-KQ-G-----N---D----FV-F-DN
S
P
D
F
L
K
K
S
V
D
E
S
L
K
R
LNTD
Y
I
D
L
F
Y
I
HFPDEH-----------------T-
P
K
D
E
A
V
N
A
L
N
E
M
K
K
AGK
I
R
S
IGVSNF
S
----
L
E
Q
L
K
E
----ANK----D----G--
L
-
V
--
D
V
L
--QG
E
Y
N
L
L
N
R
E
A
-
E
KTFFP-YTKEHN
I
S
F
I
P
Y
F
P
L
V
S
G
L
LAGKYTEDTTF-P---EGDLR---
N
E
Q
---
E
----
H
FK
G
E
R
F
-
K
-
E
N
I
R
K
V
N
K
LAP
I
A
E
-KH--NVDI
P
--
H
I
V
L
A
W
Y
LARP
E
I
D
I
L
IPGA
K
R
A
D
Q
L
I
D
NIKTAD-
V
--
T
--LS
Q
E
D
I
S
F
I
D
K
LFA
1
PsiBlast_PDB
95.09
99%
-95
- C7 -
1PYF
3
IOLS_BACSU
A:
[2-310]
-
K
K
A
K
L
G
K
S
D
L
Q
V
F
P
I
G
L
G
T
N
A
V
G
G
H
N
L
Y
P
N
L
N
E
E
T
G
K
E
L
V
R
E
A
I
R
N
G
V
T
M
L
D
T
A
Y
I
Y
G
I
-------
G
R
S
E
E
L
I
G
E
V
L
R
E
--
F
---
N
R
E
--
D
-
V
V
I
A
T
K
--
A
A
H
R
-
K
Q
-
G
-----
N
---
D
----
F
V
-
F
-
D
N
S
P
D
F
L
K
K
S
V
D
E
S
L
K
R
L
N
T
D
Y
I
D
L
F
Y
I
H
F
P
D
E
H
-----------------
T
-
P
K
D
E
A
V
N
A
L
N
E
M
K
K
A
G
K
I
R
S
I
G
V
S
N
F
S
----
L
E
Q
L
K
E
----
A
N
K
----
D
----
G
--
L
-
V
--
D
V
L
--
Q
G
E
Y
N
L
L
N
R
E
A
-
E
K
T
F
F
P
-
Y
T
K
E
H
N
I
S
F
I
P
Y
F
P
L
V
S
G
L
L
A
G
K
Y
T
E
D
T
T
F
-
P
---
E
G
D
L
R
---
N
E
Q
---
E
----
H
F
K
G
E
R
F
-
K
-
E
N
I
R
K
V
N
K
L
A
P
I
A
E
-
K
H
--
N
V
D
I
P
--
H
I
V
L
A
W
Y
L
A
R
P
E
I
D
I
L
I
P
G
A
K
R
A
D
Q
L
I
D
N
I
K
T
A
D
-
V
--
T
--
L
S
Q
E
D
I
S
F
I
D
K
L
F
A
2
PsiBlast_PDB
94.31
99%
-97
- C7 -
1PZ0
2
IOLS_BACSU
A:
[2-310]
-
K
K
A
K
L
G
K
S
D
L
Q
V
F
P
I
G
L
G
T
N
A
V
G
G
H
N
L
Y
P
N
L
N
E
E
T
G
K
E
L
V
R
E
A
I
R
N
G
V
T
M
L
D
T
A
Y
I
Y
G
I
-------
G
R
S
E
E
L
I
G
E
V
L
R
E
--
F
---
N
R
E
--
D
-
V
V
I
A
T
K
--
A
A
H
R
-
K
Q
-
G
-----
N
---
D
----
F
V
-
F
-
D
N
S
P
D
F
L
K
K
S
V
D
E
S
L
K
R
L
N
T
D
Y
I
D
L
F
Y
I
H
F
P
D
E
H
-----------------
T
-
P
K
D
E
A
V
N
A
L
N
E
M
K
K
A
G
K
I
R
S
I
G
V
S
N
F
S
----
L
E
Q
L
K
E
----
A
N
K
----
D
----
G
--
L
-
V
--
D
V
L
--
Q
G
E
Y
N
L
L
N
R
E
A
-
E
K
T
F
F
P
-
Y
T
K
E
H
N
I
S
F
I
P
Y
F
P
L
V
S
G
L
L
A
G
K
Y
T
E
D
T
T
F
-
P
---
E
G
D
L
R
---
N
E
Q
---
E
----
H
F
K
G
E
R
F
-
K
-
E
N
I
R
K
V
N
K
L
A
P
I
A
E
-
K
H
--
N
V
D
I
P
--
H
I
V
L
A
W
Y
L
A
R
P
E
I
D
I
L
I
P
G
A
K
R
A
D
Q
L
I
D
N
I
K
T
A
D
-
V
--
T
--
L
S
Q
E
D
I
S
F
I
D
K
L
F
A
78
HHSearch
91.79
99%
-76
* C7 *
1PYF
3
IOLS_BACSU
A:
[2-309]
-
K
K
A
K
L
G
K
S
D
L
Q
V
F
P
I
G
L
G
T
N
A
V
G
G
H
N
L
Y
P
N
L
N
E
E
T
G
K
E
L
V
R
E
A
I
R
N
G
V
T
M
L
D
T
A
Y
I
Y
G
I
-------
G
R
S
E
E
L
I
G
E
V
L
R
E
--
F
---
N
R
E
--
D
-
V
V
I
A
T
K
--
A
A
H
R
-
K
Q
-
G
-----
N
---
D
----
F
V
-
F
-
D
N
S
P
D
F
L
K
K
S
V
D
E
S
L
K
R
L
N
T
D
Y
I
D
L
F
Y
I
H
F
P
D
E
H
-----------------
T
-
P
K
D
E
A
V
N
A
L
N
E
M
K
K
A
G
K
I
R
S
I
G
V
S
N
F
S
----
L
E
Q
L
K
E
----
A
N
K
----
D
----
G
--
L
-
V
--
D
V
L
--
Q
G
E
Y
N
L
L
N
R
E
A
-
E
K
T
F
F
P
-
Y
T
K
E
H
N
I
S
F
I
P
Y
F
P
L
V
S
G
L
L
A
G
K
Y
T
E
D
T
T
F
-
P
---
E
G
D
L
R
---
N
E
Q
---
E
----
H
F
K
-
G
E
R
-
F
K
E
N
I
R
K
V
N
K
L
A
P
I
A
E
-
K
H
--
N
V
D
I
P
--
H
I
V
L
A
W
Y
L
A
R
P
E
I
D
I
L
I
P
G
A
K
R
A
D
Q
L
I
D
N
I
K
T
A
D
-
V
--
T
--
L
S
Q
E
D
I
S
F
I
D
K
L
F
-
9
PsiBlast_PDB
67.09
31%
-94
- C7 -
1YNQ
10
?
A:
[21-306]
M
K
K
R
Q
L
G
T
S
D
L
H
V
S
E
L
G
F
G
C
M
S
L
G
-------
T
D
E
T
K
A
R
R
I
M
D
E
V
L
E
L
G
I
N
Y
L
D
T
A
D
L
Y
N
Q
-------
G
L
N
E
Q
F
V
G
K
A
L
K
G
------
R
R
Q
--
D
-
I
I
L
A
T
K
--
V
----------------------
W
W
-
W
-
D
P
S
K
A
Y
I
K
E
A
V
K
D
S
L
R
R
L
Q
T
D
Y
I
D
L
Y
Q
L
H
G
G
T
I
D
-----------------
D
-
P
I
D
E
T
I
E
A
F
E
E
L
K
Q
E
G
V
I
R
Y
Y
G
I
S
S
I
R
----
P
N
V
I
K
E
----
Y
L
K
----
R
----
S
--
N
-
I
--
V
S
I
--
M
M
Q
Y
S
I
L
D
R
R
P
-
E
E
-
W
F
P
-
L
I
Q
E
H
G
V
S
V
V
V
R
G
P
V
A
R
G
L
L
S
R
R
-----
P
L
-
P
---
E
G
------------
E
----
G
Y
L
N
Y
R
Y
-
D
-
E
-------
L
K
L
L
R
E
-
S
L
--
P
T
D
R
P
L
H
E
L
A
L
Q
Y
C
L
A
H
D
V
V
A
T
V
A
A
G
A
S
S
I
D
Q
V
K
A
N
V
Q
A
V
E
-
A
--
T
P-
L
T
A
E
E
R
Q
H
I
Q
K
L
--
79
HHSearch
65.72
38%
-10
- C7 -
1PZ1
1
GS69_BACSU
A:
[1-310]
M
E
Y
T
S
I
A
D
T
G
I
E
A
S
R
I
G
L
G
T
W
A
I
G
G
T
M
W
G
G
-
T
D
E
K
T
S
I
E
T
I
R
A
A
L
D
Q
G
I
T
L
I
D
T
A
P
A
Y
G
F
-------
G
Q
S
E
E
I
V
G
K
A
I
K
E
--
Y
M--
K
R
D
--
Q
-
V
I
L
A
T
K
--
T
A
L
D
-
W
K
-
N
-----
N
---
Q
----
L
F
-
R
-
H
A
N
R
A
R
I
V
E
E
V
E
N
S
L
K
R
L
Q
T
D
Y
I
D
L
Y
Q
V
H
W
P
D
P
L
-----------------
V
-
P
I
E
E
T
A
E
V
M
K
E
L
Y
D
A
G
K
I
R
A
I
G
V
S
N
F
S
----
I
E
Q
M
D
T
----
F
R
A
----
V
----
A
--
P
-
L
--
H
T
I
--
Q
P
P
Y
N
L
F
E
R
E
M
-
E
E
S
V
L
P
-
Y
A
K
D
N
K
I
T
T
L
L
Y
G
S
L
C
R
G
L
L
T
G
K
M
T
E
E
Y
T
F
-
E
---
G
D
D
L
R
---
N
H
D
---
P
----
K
F
Q
K
P
R
F
-
K
-
E
Y
L
S
A
V
N
Q
L
D
K
L
A
K
T
R
Y
--
G
K
S
V
I
--
H
L
A
V
R
W
I
L
D
Q
P
G
A
D
I
A
L
W
G
A
R
K
P
G
Q
L
E
A
L
S
E
I
T
G
-
W
--
T
--
L
N
S
E
D
Q
K
D
I
N
T
I
L
-
8
PsiBlast_PDB
64.43
31%
-97
- C7 -
1YNP
12
?
A:
[21-306]
M
K
K
R
Q
L
G
T
S
D
L
H
V
S
E
L
G
F
G
C
M
S
L
G
-------
T
D
E
T
K
A
R
R
I
M
D
E
V
L
E
L
G
I
N
Y
L
D
T
A
D
L
Y
N
Q
-------
G
L
N
E
Q
F
V
G
K
A
L
K
G
------
R
R
Q
--
D
-
I
I
L
A
T
K
--
V
-----------------------------
S
K
A
Y
I
K
E
A
V
K
D
S
L
R
R
L
Q
T
D
Y
I
D
L
Y
Q
L
H
G
G
T
I
D
-----------------
D
-
P
I
D
E
T
I
E
A
F
E
E
L
K
Q
E
G
V
I
R
Y
Y
G
I
S
S
I
R
----
P
N
V
I
K
E
----
Y
L
K
----
R
----
S
--
N
-
I
--
V
S
I
--
M
M
Q
Y
S
I
L
D
R
R
P
-
E
E
-
W
F
P
-
L
I
Q
E
H
G
V
S
V
V
V
R
G
P
V
A
R
G
L
L
S
R
R
-----
P
L
-
P
---
E
G
------------
E
----
G
Y
L
N
Y
R
Y
-
D
-
E
-------
L
K
L
L
R
E
-
S
L
--
P
T
D
R
P
L
H
E
L
A
L
Q
Y
C
L
A
H
D
V
V
A
T
V
A
A
G
A
S
S
I
D
Q
V
K
A
N
V
Q
A
V
E
-
A
--
T
P-
L
T
A
E
E
R
Q
H
I
Q
K
L
--
3
PsiBlast_PDB
64.29
37%
-11
- C7 -
1PZ1
1
GS69_BACSU
A:
[6-310]
-----
I
A
D
T
G
I
E
A
S
R
I
G
L
G
T
W
A
I
G
G
-
T
M
W
G
G
T
D
E
K
T
S
I
E
T
I
R
A
A
L
D
Q
G
I
T
L
I
D
T
A
P
A
Y
G
F
-------
G
Q
S
E
E
I
V
G
K
A
I
K
E
--
Y
---
M
K
R
--
D
Q
V
I
L
A
T
K
--
T
A
L
D
-
W
K
-
N
-----
N
---
Q
----
L
F
-
R
-
H
A
N
R
A
R
I
V
E
E
V
E
N
S
L
K
R
L
Q
T
D
Y
I
D
L
Y
Q
V
H
W
P
D
P
L
-----------------
V
-
P
I
E
E
T
A
E
V
M
K
E
L
Y
D
A
G
K
I
R
A
I
G
V
S
N
F
S
----
I
E
Q
M
D
T
----
F
R
A
----
V
----
A
--
P
-
L
--
H
T
I
--
Q
P
P
Y
N
L
F
E
R
E
M
-
E
E
S
V
L
P
-
Y
A
K
D
N
K
I
T
T
L
L
Y
G
S
L
C
R
G
L
L
T
G
K
M
T
E
E
Y
T
F
-
E
---
G
D
D
L
R
---
N
H
D
---
P
----
K
F
Q
K
P
R
F
-
K
-
E
Y
L
S
A
V
N
Q
L
D
K
L
A
K
T
R
Y
--
G
K
S
V
I
--
H
L
A
V
R
W
I
L
D
Q
P
G
A
D
I
A
L
W
G
A
R
K
P
G
Q
L
E
A
L
S
E
I
T
G
-
W
--
T
--
L
N
S
E
D
Q
K
D
I
N
T
I
L
-
84
HHSearch
63.51
32%
-98
- C7 -
1YNP
13
?
A:
[21-307]
M
K
K
R
Q
L
G
T
S
D
L
H
V
S
E
L
G
F
G
C
M
S
L
G
T
-------
D
E
T
K
A
R
R
I
M
D
E
V
L
E
L
G
I
N
Y
L
D
T
A
D
L
Y
N
Q
-------
G
L
N
E
Q
F
V
G
K
A
L
K
G
--
R
----
R
Q
--
D
-
I
I
L
A
T
K
--
V
-----------------------------
S
K
A
Y
I
K
E
A
V
K
D
S
L
R
R
L
Q
T
D
Y
I
D
L
Y
Q
L
H
G
G
T
I
D
-----------------
D
-
P
I
D
E
T
I
E
A
F
E
E
L
K
Q
E
G
V
I
R
Y
Y
G
I
S
S
I
R
----
P
N
V
I
K
E
----
Y
L
K
----
R
----
S
--
N
-
I
--
V
S
I
--
M
M
Q
Y
S
I
L
D
R
R
P
-
E
-
E
W
F
P
-
L
I
Q
E
H
G
V
S
V
V
V
R
G
P
V
A
R
G
L
L
S
R
R
P
L
P
E
G
E
G
----------------------------------
Y
L
N
Y
R
Y
D
E
L
K
L
L
R
E
-
S
L
PT
D
R
P
L
H
--
E
L
A
L
Q
Y
C
L
A
H
D
V
V
A
T
V
A
A
G
A
S
S
I
D
Q
V
K
A
N
V
Q
A
V
E
A
T
--
P
--
L
T
A
E
E
R
Q
H
I
Q
K
L
A
-
80
HHSearch
58.68
31%
15
- C7 -
3N2T
-
?
A:
[3-313]
S
D
T
I
R
I
P
G
I
D
T
P
L
S
R
V
A
L
G
T
W
A
I
G
G
W
M
W
G
G
-
P
D
D
D
N
G
V
R
T
I
H
A
A
L
D
E
G
I
N
L
I
D
T
A
P
V
Y
G
F
-------
G
H
S
E
E
I
V
G
R
A
L
A
E
--
K
----
P
N
--
K
-
A
H
V
A
T
K
--
L
G
L
H
-
W
V
-
G
ED---
E
KN
M
K
----
V
F
-
R
-
D
S
R
P
A
R
I
R
K
E
V
E
D
S
L
R
R
L
R
V
E
T
I
D
L
E
Q
I
H
W
P
D
D
K
-----------------
T
-
P
I
D
E
S
A
R
E
L
Q
K
L
H
Q
D
G
K
I
R
A
L
G
V
S
N
F
S
----
P
E
Q
M
D
I
----
F
R
E
----
V
----
A
--
P
-
L
--
A
T
I
--
Q
P
P
L
N
L
F
E
R
T
I
-
E
K
D
I
L
P
-
Y
A
E
K
H
N
A
V
V
L
A
Y
G
A
L
C
R
G
L
L
T
G
K
M
N
R
D
T
T
F
-
P
---
K
D
D
L
R
---
S
N
D
---
P
----
K
F
Q
K
-
P
N
-
F
E
K
Y
L
A
A
M
D
E
F
E
K
L
A
E
-
K
R
--
G
K
S
V
M
--
A
F
A
V
R
W
V
L
D
Q
G
P
V
-
I
A
L
W
G
A
R
K
P
G
Q
V
S
G
V
K
D
V
F
G
-
W
--
S
--
L
T
D
E
E
K
K
A
V
D
D
I
L
-
92
HHSearch
57.98
28%
-61
- C7 -
4WGH
2
?
A:
[25-294]
K
K
T
V
R
F
G
-
E
Q
A
A
V
P
A
I
G
L
G
T
W
Y
M
G
E
H
-
A
---
A
Q
R
Q
Q
E
V
A
A
L
R
A
G
I
D
H
G
L
T
V
I
D
T
A
E
M
Y
A
D
-------
G
G
A
E
E
V
V
G
Q
A
I
R
G
--
L
----
R
D
--
R
-
V
V
L
V
S
K
--
V
Y
P
-----------------------
W
-
H
A
G
K
A
A
M
H
R
A
C
E
N
S
L
R
R
L
Q
T
D
Y
L
D
M
Y
L
L
H
W
R
G
D
I
-------------------
P
L
Q
E
T
V
E
A
M
E
K
L
V
A
E
G
K
I
R
R
W
G
V
S
N
L
D
----
T
E
D
M
Q
A
----
L
W
R
----
T
AD--
G
--
E
H
C
--
A
T
N
--
Q
V
L
Y
H
L
A
S
R
G
I
-
E
Y
D
L
L
P
-
W
C
Q
Q
H
S
L
P
V
M
A
Y
C
P
L
A
Q
A
G
R
L
R
D
G
L
F
------------------------------------------
Q
H
S
D
I
I
N
M
A
N
-
A
R
--
G
I
T
V
A
--
Q
L
L
L
A
W
V
I
R
H
P
G
V
L
-
A
I
P
K
A
A
S
I
E
H
V
V
Q
N
A
A
A
L
D
-
I
--
V
--
L
S
G
E
E
L
A
Q
L
D
R
L
Y
-
83
HHSearch
56.30
27%
7
- C7 -
3EAU
3
KCAB2_RAT
A:
[3-321]
Q
F
Y
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
F
G
G
Q
----
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
A
-------
G
K
A
E
V
V
L
G
N
I
I
K
K
--
K
GW-
R
R
S
--
S
-
L
V
I
T
T
K
--
I
F
W
G
-
G
K
-
A
-----
E
---
T
----
E
--
R
-
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
R
P
D
P
N
-----------------
T
-
P
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
----
S
M
E
I
M
E
----
A
Y
S
----
V
A
R
Q
F
N
L-
I
P
P
--
I
C
E
--
Q
A
E
Y
H
M
F
Q
R
E
K
V
E
V
Q
L
P
E
-
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
G
I
P
P
-
Y
S--
R
A
S
L
K
GY
Q
W
L
K
---
D
----
K
I
L
S
E
E
G
-
R
-
R
Q
Q
A
K
L
K
E
L
Q
A
I
A
E
-
R
L
--
G
C
T
L
P
--
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
--
L
S
S
S
I
V
H
E
I
D
S
I
L
-
7
PsiBlast_PDB
56.20
33%
23
- C7 -
3N2T
-
?
A:
[18-314]
---------------
V
A
L
G
T
W
A
I
G
G
W
-
M
W
G
G
P
D
D
D
N
G
V
R
T
I
H
A
A
L
D
E
G
I
N
L
I
D
T
A
P
V
Y
G
F
-------
G
H
S
E
E
I
V
G
R
A
L
A
E
------
K
P
N
--
K
-
A
H
V
A
T
K
--
L
G
L
H
-
W
V
-
G
-----
E
---
D
EKN
M
K
V
-
F
R
D
S
R
P
A
R
I
R
K
E
V
E
D
S
L
R
R
L
R
V
E
T
I
D
L
E
Q
I
H
W
P
D
D
K
-----------------
T
-
P
I
D
E
S
A
R
E
L
Q
K
L
H
Q
D
G
K
I
R
A
L
G
V
S
N
F
S
----
P
E
Q
M
D
I
----
F
R
E
----
V
----
A
--
P
-
L
--
A
T
I
--
Q
P
P
L
N
L
F
E
R
T
I
-
E
K
D
I
L
P
-
Y
A
E
K
H
N
A
V
V
L
A
Y
G
A
L
C
R
G
L
L
T
G
K
M
N
R
D
T
T
F
-
P
---
K
D
D
L
R
---
S
N
D
---
P
----
K
F
Q
K
P
N
F
-
E
-
K
Y
L
A
A
M
D
E
F
E
K
L
A
E
-
K
R
--
G
K
S
V
M
--
A
F
A
V
R
W
V
L
D
Q
G
P
V
-
I
A
L
W
G
A
R
K
P
G
Q
V
S
G
V
K
D
V
F
G
-
W
--
S
--
L
T
D
E
E
K
K
A
V
D
D
I
L
A
22
PsiBlast_CBE
55.96
31%
3
- C7 -
1YNP
6
?
B:
[21-306]
M
K
K
R
Q
L
G
T
S
D
L
H
V
S
E
L
G
F
G
C
M
S
L
G
-------
T
D
E
T
K
A
R
R
I
M
D
E
V
L
E
L
G
I
N
Y
L
D
T
A
D
L
Y
N
Q
-------
G
L
N
E
Q
F
V
G
K
A
L
K
G
------
R
R
Q
--
D
-
I
I
L
A
T
K
--
V
G
N
R
F
E
Q
-
G
-----
K
---
E
G
---
W
W
-
W
-
D
P
S
K
A
Y
I
K
E
A
V
K
D
S
L
R
R
L
Q
T
D
Y
I
D
L
Y
Q
L
H
G
G
T
I
D
-----------------
D
-
P
I
D
E
T
I
E
A
F
E
E
L
K
Q
E
G
V
I
R
Y
Y
G
I
S
S
I
R
----
P
N
V
I
K
E
----
Y
L
K
----
R
----
S
--
N
-
I
--
V
S
I
--
M
M
Q
Y
S
I
L
D
R
R
P
-
E
E
-
W
F
P
-
L
I
Q
E
H
G
V
S
V
V
V
R
G
P
V
A
R
G
L
L
S
R
R
-----
P
L
-
P
---
E
G
------------
E
----
G
Y
L
N
Y
R
Y
-
D
-
E
-------
L
K
L
L
R
E
-
S
L
--
P
T
D
R
P
L
H
E
L
A
L
Q
Y
C
L
A
H
D
V
V
A
T
V
A
A
G
A
S
S
I
D
Q
V
K
A
N
V
Q
A
V
E
-
A
--
T
P-
L
T
A
E
E
R
Q
H
I
Q
K
L
--
21
PsiBlast_CBE
55.63
31%
4
- C7 -
1YNQ
10
?
B:
[21-306]
M
K
K
R
Q
L
G
T
S
D
L
H
V
S
E
L
G
F
G
C
M
S
L
G
-------
T
D
E
T
K
A
R
R
I
M
D
E
V
L
E
L
G
I
N
Y
L
D
T
A
D
L
Y
N
Q
-------
G
L
N
E
Q
F
V
G
K
A
L
K
G
------
R
R
Q
--
D
-
I
I
L
A
T
K
--
V
G
N
R
F
E
Q
-
G
-----
K
---
E
G
---
W
W
-
W
-
D
P
S
K
A
Y
I
K
E
A
V
K
D
S
L
R
R
L
Q
T
D
Y
I
D
L
Y
Q
L
H
G
G
T
I
D
-----------------
D
-
P
I
D
E
T
I
E
A
F
E
E
L
K
Q
E
G
V
I
R
Y
Y
G
I
S
S
I
R
----
P
N
V
I
K
E
----
Y
L
K
----
R
----
S
--
N
-
I
--
V
S
I
--
M
M
Q
Y
S
I
L
D
R
R
P
-
E
E
-
W
F
P
-
L
I
Q
E
H
G
V
S
V
V
V
R
G
P
V
A
R
G
L
L
S
R
R
-----
P
L
-
P
---
E
G
------------
E
----
G
Y
L
N
Y
R
Y
-
D
-
E
-------
L
K
L
L
R
E
-
S
L
--
P
T
D
R
P
L
H
E
L
A
L
Q
Y
C
L
A
H
D
V
V
A
T
V
A
A
G
A
S
S
I
D
Q
V
K
A
N
V
Q
A
V
E
-
A
--
T
P-
L
T
A
E
E
R
Q
H
I
Q
K
L
--
14
PsiBlast_PDB
55.09
27%
14
- C7 -
3EB3
2
KCAB2_RAT
A:
[8-322]
-----
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
F
G
G
Q
I
----
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
A
-------
G
K
A
E
V
V
L
G
N
I
I
K
K
K
G
W
---
R
R
S
--
S
-
L
V
I
T
T
K
I
F
A
G
G
K
-
A
E
-
T
-----
E
---
R
----
G
L
-----
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
R
P
D
P
N
-----------------
T
-
P
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
S
M
E
I
M
E
A
Y
S
V
----
A
R
Q
----
F
----
N
--
L
-
I
--
P
P
I
CE
Q
A
E
Y
H
M
F
Q
R
E
K
-
V
E
V
Q
L
P
E
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
--
D
S
G
I
-
P
PYS
R
A
S
L
K
---
G
Y
Q
W
L
K
D
----
K
I
L
S
E
E
G
-
R
-
R
Q
Q
A
K
L
K
E
L
Q
A
I
A
E
-
R
L
--
G
C
T
L
P
--
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
--
L
PK
L
S
S
S
I
V
H
E
I
D
S
I
L
G
86
HHSearch
54.61
28%
35
- C7 -
1LQA
1
TAS_ECOLI
A:
[1-338]
M
Q
Y
H
R
I
P
H
S
S
L
E
V
S
T
L
G
L
G
T
M
T
F
G
E
Q
-----
N
S
E
A
D
A
H
A
Q
L
D
Y
A
V
A
Q
G
I
N
L
I
D
V
A
E
M
Y
P
V
PPRPETQ
G
L
T
E
T
Y
V
G
N
W
L
A
K
--
H
G--
S
R
E
--
K
-
L
I
I
A
S
K
--
V
S
G
P
-
S
R
-
N
NDKGI
R
---
P
----
D
--
Q
-
A
L
D
R
K
N
I
R
E
A
L
H
D
S
L
K
R
L
Q
T
D
Y
L
D
L
Y
Q
V
H
W
P
Q
R
P
TNCFGKL
G
Y
S
W
T
DSAPA
V
-
S
L
L
D
T
L
D
A
L
A
E
Y
Q
R
A
G
K
I
R
Y
I
G
V
S
N
E
T
----
A
F
G
V
M
R
----
Y
L
H
L
A
D
K
H
----
D
LP
R
-
I
--
V
T
I
--
Q
N
P
Y
S
L
L
N
R
S
F
-
E
V
G
L
A
E
-
V
S
Q
Y
E
G
V
E
L
L
A
Y
S
C
L
G
F
G
T
L
T
G
K
Y
L
N
G
A
K
P
-
A
---
G
--
A
R
---
N
T
L
---
F
S---
R
F
T
R
Y
S
G
-
E
-
Q
T
Q
K
A
V
A
A
Y
V
D
I
A
R
-
R
H
--
G
L
D
P
A
--
Q
M
A
L
A
F
V
R
R
Q
P
F
V
A
S
T
L
L
G
A
T
T
M
D
Q
L
K
T
N
I
E
S
L
H
-
L
--
E
--
L
S
E
D
V
L
A
E
I
E
A
V
H
-
90
HHSearch
54.55
28%
-40
- C7 -
5C7H
1
?
A:
[5-269]
I
P
T
I
A
F
P
-
D
G
R
K
V
P
A
L
G
Q
G
T
W
R
M
G
E
N
-
R
A
---
K
T
A
D
E
V
R
S
L
Q
T
G
L
D
L
G
M
T
L
I
D
T
A
E
M
Y
G
D
-------
G
A
A
E
R
I
V
G
E
A
I
K
G
--
R
----
R
D
--
E
-
A
F
V
V
S
K
--
V
L
P
-----------------------
S
-
N
A
S
R
A
G
T
V
A
A
C
E
R
S
L
R
N
L
G
I
D
C
V
D
L
Y
L
L
H
W
R
G
G
Y
-------------------
P
L
A
E
T
V
A
A
F
E
E
L
K
K
A
G
K
I
R
A
W
G
V
S
N
F
D
----
V
D
D
M
E
E
----
L
S
A
V
PD-
G
----
G
--
N
-
V
--
A
A
N
--
Q
V
L
Y
N
L
A
R
R
G
I
-
E
F
D
L
L
P
-
R
C
R
A
Q
G
V
P
V
M
A
Y
S
P
L
D
E
G
R
L
L
H
D
-----------------------------------------------
A
D
L
I
H
I
A
K
-
A
H
--
Q
A
T
P
A
--
Q
V
A
L
A
F
L
K
T
C
S
G
V
-
I
S
I
P
K
T
G
S
P
E
R
A
R
E
N
R
D
A
M
D
-
I
--
H
--
L
T
T
E
N
L
A
E
L
D
R
H
F
-
87
HHSearch
54.45
27%
15
- C7 -
3LUT
1
KCAB2_RAT
A:
[37-355]
Q
F
Y
R
N
L
G
K
S
G
L
R
V
S
C
L
G
L
G
T
W
V
T
F
G
G
Q
----
I
T
D
E
M
A
E
H
L
M
T
L
A
Y
D
N
G
I
N
L
F
D
T
A
E
V
Y
A
A
-------
G
K
A
E
V
V
L
G
N
I
I
K
K
K
G
W
---
R
R
S
--
S
-
L
V
I
T
T
K
--
I
F
W
G
-
G
K
-
A
-----
E
---
T
----
E
--
R
-
G
L
S
R
K
H
I
I
E
G
L
K
A
S
L
E
R
L
Q
L
E
Y
V
D
V
V
F
A
N
R
P
D
P
N
-----------------
T
-
P
M
E
E
T
V
R
A
M
T
H
V
I
N
Q
G
M
A
M
Y
W
G
T
S
R
W
S
----
S
M
E
I
M
E
----
A
Y
S
----
V
A
R
Q
F
N
L-
I
P
P
--
I
C
E
--
Q
A
E
Y
H
M
F
Q
R
E
K
V
E
V
Q
L
P
E
-
L
F
H
K
I
G
V
G
A
M
T
W
S
P
L
A
C
G
I
V
S
G
K
Y
D
S
G
I
P
P
Y
S
---
R
A
-
S
L
---
K
G
Y
---
Q
W
L
K
D
K
I
L
S
E
E
G
-
R
-
R
Q
Q
A
K
L
K
E
L
Q
A
I
A
E
-
R
L
--
G
C
T
L
P
--
Q
L
A
I
A
W
C
L
R
N
E
G
V
S
S
V
L
L
G
A
S
N
A
E
Q
L
M
E
N
I
G
A
I
Q
-
V
LP
K
--
L
S
S
S
I
V
H
E
I
D
S
I
L
-
89
HHSearch
54.33
28%
21
- C7 -
3ERP
17
?
A:
[34-349]
M
E
Y
R
R
C
G
R
S
G
V
K
L
P
A
I
S
L
G
L
W
H
N
F
G
D
----
T
T
R
V
E
N
S
R
A
L
L
Q
R
A
F
D
L
G
I
T
H
F
D
L
A
N
N
Y
G
P
PP-----
G
S
A
E
C
N
F
G
R
I
L
Q
E
--
D
FLP
W
R
D
--
E
-
L
I
I
S
T
K
--
A
G
Y
T
-
M
W
D
G
-----
P
---
Y
----
G
--
D
-
W
G
S
R
K
Y
L
I
A
S
L
D
Q
S
L
K
R
M
G
L
E
Y
V
D
I
F
Y
H
H
R
P
D
P
E
-----------------
T
-
P
L
K
E
T
M
K
A
L
D
H
L
V
R
H
G
K
A
L
Y
V
G
I
S
N
Y
P
----
A
D
L
A
R
Q
----
A
I
D
I
L
E
D
L
----
G
--
T
P
C
--
L
I
H
--
Q
P
K
Y
S
L
F
E
R
W
V
-
E
D
G
L
L
A
-
L
L
Q
E
K
G
V
G
S
I
A
F
S
P
L
A
G
G
Q
L
T
D
R
Y
L
N
----------------------------------
I
T
A
-
D
K
L
E
K
V
R
R
L
N
E
L
A
A
-
R
R
--
G
Q
K
L
S
--
Q
M
A
L
A
W
V
L
R
N
D
N
V
T
S
V
L
I
G
A
S
K
P
S
Q
I
E
D
A
V
G
M
L
A
N
R
--
R
--
F
S
A
A
E
C
A
E
I
D
A
I
L
-
4
PsiBlast_PDB
54.13
32%
-5
- C7 -
3UYI
-
PERR_RAUSE
A:
[1-306]
M
P
R
V
K
L
G
T
Q
G
L
E
V
S
K
L
G
F
G
C
M
G
L
S
G
------
L
P
E
E
Q
G
I
A
V
I
K
E
A
F
N
C
G
I
T
F
F
D
T
S
D
I
Y
G
E
N------
G
S
N
E
E
L
L
G
K
A
L
K
Q
--
L
---
P
R
E
--
K
-
I
Q
V
G
T
K
--
F
G
I
H
-
E
I
-
G
-----
F
---
S
----
G
V
K
A
-
K
G
T
P
D
Y
V
R
S
C
C
E
A
S
L
K
R
L
D
V
D
Y
I
D
L
F
Y
I
H
R
I
D
T
T
-----------------
V
-
P
I
E
I
T
M
G
E
L
-
K
L
V
E
E
G
K
I
K
Y
V
G
L
S
E
A
S
----
P
D
T
I
R
R
----
A
H
A
----
V
----
H
--
P
-
V
--
T
A
L
--
Q
I
E
Y
S
L
W
T
R
D
I
-
E
D
E
I
V
P
-
L
C
R
Q
L
G
I
G
I
V
P
Y
S
P
I
G
R
G
L
F
A
G
K
A
I
K
E
-
S
-----------------------------------
K
N
K
Q
I
Y
Y
R
I
E
A
L
S
Q
-
K
H
--
G
C
T
P
V
--
Q
L
A
L
A
W
V
L
H
Q
G
E
D
V
V
P
I
P
G
T
T
K
I
K
N
L
H
N
N
V
G
A
L
K
-
V
--
K
--
L
T
K
E
D
L
K
E
I
S
----
95
HHSearch
50.17
31%
8
- C7 -
3O0K
4
?
A:
[26-282]
V
P
T
V
K
L
-
N
D
G
N
H
I
P
Q
L
G
Y
G
V
W
Q
I
---------
S
N
D
E
A
V
S
A
V
S
E
A
L
K
A
G
Y
R
H
I
D
T
A
T
I
Y
G
N
----------
E
E
G
V
G
K
A
I
N
G
--
S
GI-
A
R
A
--
D
-
I
F
L
T
T
K
--
L
W
N
-----------------------
S
-
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
M
P
S
-----------------
K
D
L
F
M
E
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
----
T
A
D
L
E
R
----
L
I
K
----
E
S
---
G
--
V
T
P
--
V
L
N
--
Q
I
E
L
H
P
Q
F
Q
Q
---
D
E
L
R
L
-
F
H
G
K
H
D
I
A
T
E
A
W
S
P
L
G
Q
G
-
L
L
E
D
-----------------------------------------------
P
T
L
K
S
I
A
E
-
K
H
--
A
K
S
V
A
--
Q
I
I
L
R
W
H
I
E
T
G
N
--
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
-
F
--
T
--
L
N
G
T
D
H
D
A
I
T
K
L
--
23
PsiBlast_CBE
43.93
33%
10
- C7 -
1GVE
5
ARK73_RAT
A:
[28-226]
----------------------------------------
V
R
A
F
L
Q
R
G
H
T
E
I
D
T
A
F
V
Y
A
N
-------
G
Q
S
E
T
I
L
G
D
L
G
L
G
--
L
---
G
R
S
GC
K
-
V
K
I
A
T
K
--
A
A
P
M
-------------------
F
G
-
K
-
T
L
K
P
A
D
V
R
F
Q
L
E
T
S
L
K
R
L
Q
C
P
R
V
D
L
F
Y
L
H
F
P
D
H
G
-----------------
T
-
P
I
E
E
T
L
Q
A
C
H
Q
L
H
Q
E
G
K
F
V
E
L
G
L
S
N
Y
V
----
S
W
E
V
A
E
I
C
T
L
C
K
K
----
N
----
G
--
W
-
I
MP
T
V
Y
--
Q
G
M
Y
N
A
I
T
R
Q
V
-
E
T
E
L
F
P
-
C
L
R
H
F
G
L
R
F
Y
A
F
N
P
L
A
G
G
L
L
T
G
R
Y
----
K
Y
-
Q
---
D
K
D
G
K
---
N
P
E
---
S
----
R
F
F
G
N
P
F
-
S
-
Q
--------------------------------------------------------------------------------