@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu39840: (2016-08-06 )
MGRLENKTAVITGAATGIGQATAEVFANEGARVIIGDINKDQMEETVDAIRKNGGQAESFHLDVSDENSVKAFADQIKDACGTIDILFNNAGVDQEGGKVHEYPVDLFDRIIAVDLRGTFLCSKYLIPLMLENGGSIINTSSMSGRAADLDRSGYNAAKGGITNLTKAMAIDYARNGIRVNSISPGTIETPLIDKLAGTKEQEMGEQFREANKWITPLGRLGQPKEMATVALFLASDDSSYVTGEDITADGGIMAYTWPGKMLIEEKWKEETK
Atome Classification :
(22 SA)
.........10........20........30........40-........50........60........70........80........90.......-.100.......110.......120.......130.--.-.-....140.......150--.......160.......170.....--..180.......190.......200......----.210..--.....220.......230.......240.......250.......260.......270.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGRLENK
T
A
V
I
T
GAATG
I
G
Q
A
T
A
E
V
F
ANEG
A
R
V
I
I
GDI
N
K
D
-
Q
M
E
E
T
V
D
A
I
R
KNGGQA
E
S
F
H
L
DVSDEN
S
V
K
A
F
A
D
Q
I
K
D
ACG
T
I
D
I
L
FNNAGVDQEGG-
K
V
HEY
P
V
D
L
F
D
R
I
I
A
V
DLR
G
T
F
L
C
S
K
Y
L
I
P
L
M
LEN--G-G-
S
I
I
NTSSMSGRAADLDR--SGYNAAKG
G
I
T
N
L
T
K
A
M
A
I
D
Y
ARNG--
I
R
VNSISPGTIET
P
L
I
D
K
LAGT
K
E
Q
E
M
G
E
Q
F
----
R
E
AN
K
W
--
I
TPLGRLGQPK
E
M
A
T
V
A
L
F
L
ASDDSSYVTGEDITADG
G
I
M
A
Y
TWPG
K
M
L
I
E
E
K
W
KEETK
9
PsiBlast_PDB
87.56
37%
-69
- C2 -
3R1I
2
?
A:
[30-276]
---
L
S
G
K
R
A
L
I
T
G
A
S
T
G
I
G
K
K
V
A
L
A
Y
A
E
A
G
A
Q
V
A
V
A
A
R
H
S
D
-
A
L
Q
V
V
A
D
E
I
A
G
V
G
G
K
A
L
P
I
R
C
D
V
T
Q
P
D
Q
V
R
G
M
L
D
Q
M
T
G
E
L
G
G
I
D
I
A
V
C
N
A
G
I
V
S
V
Q
A
-
M
L
-
D
M
P
L
E
E
F
Q
R
I
Q
D
T
N
V
T
G
V
F
L
T
A
Q
A
A
A
R
A
M
V
D
Q
GL
G
-
G
-
T
I
I
T
T
A
S
M
S
G
H
I
I
N
I
P
Q
QV
S
H
Y
C
T
S
K
A
A
V
V
H
L
T
K
A
M
A
V
E
L
A
P
H
Q
--
I
R
V
N
S
V
S
P
G
Y
I
R
T
E
L
V
E
P
L
A
---------
D
Y
----
H
A
L
W
E
P
--
K
I
P
L
G
R
M
G
R
P
E
E
L
T
G
L
Y
L
Y
L
A
S
A
A
S
S
Y
M
T
G
S
D
I
V
I
D
G
G
---
Y
T
C
P
--------------
105
HHSearch
86.09
38%
-44
- C2 -
4G81
2
?
D:
[5-253]
-
F
D
L
T
G
K
T
A
L
V
T
G
S
A
R
G
L
G
F
A
Y
A
E
G
L
A
A
A
G
A
R
V
I
L
N
D
I
R
A
T
-
L
L
A
E
S
V
D
T
L
T
R
K
G
Y
D
A
H
G
V
A
F
D
V
T
D
E
L
A
I
E
A
A
F
S
K
L
D
A
E
G
I
H
V
D
I
L
I
N
N
A
G
I
Q
Y
R
-
K
-
P
M
V
E
L
E
L
E
N
W
Q
K
V
I
D
T
N
L
T
S
A
F
L
V
S
R
S
A
A
K
R
M
I
A
R
NS
G
-
G
-
K
I
I
N
I
G
S
L
T
S
Q
A
A
R
P
T
V
--
A
P
Y
T
A
A
K
G
G
I
K
M
L
T
C
S
M
A
A
E
W
A
Q
F
N
--
I
Q
T
N
A
I
G
P
G
Y
I
L
T
D
M
N
T
A
L
I
E
D
------
K
Q
F
----
D
S
W
V
K
S
--
S
T
P
S
Q
R
W
G
R
P
E
E
L
I
G
T
A
I
F
L
S
S
K
A
S
D
Y
I
N
G
Q
I
I
Y
V
D
G
G
W
L
A
------------------
113
HHSearch
85.66
37%
-33
- C2 -
4URF
9
?
A:
[2-247]
--
L
L
E
G
K
T
A
L
V
T
G
A
G
N
G
I
G
R
T
I
A
L
T
Y
A
A
E
G
A
N
V
V
V
S
D
I
S
D
E
-
W
G
R
E
T
L
A
L
I
E
G
K
G
G
K
A
V
F
Q
H
A
D
T
A
H
P
E
D
H
D
E
L
I
A
A
A
K
R
A
F
G
R
L
D
I
A
C
N
N
A
G
I
S
G
E
F
T
-
P
T
A
E
T
T
D
A
Q
W
Q
R
V
I
G
I
N
L
S
G
V
F
Y
G
V
R
A
Q
I
R
A
M
L
E
T
G-
G
-
G
-
A
I
V
N
I
S
S
I
A
G
Q
I
G
I
E
G
I
--
T
P
Y
T
A
A
K
H
G
V
V
G
L
T
K
T
V
A
W
E
Y
G
S
K
G
--
I
R
I
N
S
V
G
P
A
F
I
N
T
T
L
V
Q
N
V
P
L
E
T
----
R
--------
R
Q
L
E
Q
--
M
H
A
L
R
R
L
G
E
T
E
E
V
A
N
L
V
A
W
L
S
S
D
K
A
S
F
V
T
G
S
Y
Y
A
V
D
G
G
Y
L
A
------------------
23
PsiBlast_CBE
85.52
41%
-48
- C2 -
4NBU
2
?
B:
[8-249]
M
S
R
L
Q
D
K
V
A
I
I
T
G
A
A
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
V
I
A
D
F
N
E
A
-
A
G
K
E
A
V
E
A
---
N
P
G
V
V
-
F
I
R
V
D
V
S
D
R
E
S
V
H
R
L
V
E
N
V
A
E
R
F
G
K
I
D
I
L
I
N
N
A
G
I
T
R
D
S
--
M
L
S
K
M
T
V
D
Q
F
Q
Q
V
I
N
V
N
L
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
A
E
Q
--
G
K
G
-
K
I
I
N
T
S
S
V
T
G
T
Y
G
N
V
G
Q
--
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
L
A
R
K
G
--
I
N
V
N
A
V
A
P
G
F
T
E
T
A
M
V
--------
A
E
V
P
E
K
V
----
I
E
K
M
K
A
--
Q
V
P
M
G
R
L
G
K
P
E
D
I
A
N
A
Y
L
F
L
A
S
H
E
S
D
Y
V
N
G
H
V
L
H
V
D
G
G
I
M
-------------------
1
PsiBlast_PDB
85.19
41%
-50
- C2 -
4NBU
1
?
A:
[9-249]
-
S
R
L
Q
D
K
V
A
I
I
T
G
A
A
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
V
I
A
D
F
N
E
A
-
A
G
K
E
A
V
E
A
---
N
P
G
V
V
-
F
I
R
V
D
V
S
D
R
E
S
V
H
R
L
V
E
N
V
A
E
R
F
G
K
I
D
I
L
I
N
N
A
G
I
T
R
D
S
--
M
L
S
K
M
T
V
D
Q
F
Q
Q
V
I
N
V
N
L
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
A
E
Q
--
G
K
G
-
K
I
I
N
T
S
S
V
T
G
T
Y
G
N
V
G
Q
--
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
L
A
R
K
G
--
I
N
V
N
A
V
A
P
G
F
T
E
T
A
M
V
--------
A
E
V
P
E
K
V
----
I
E
K
M
K
A
--
Q
V
P
M
G
R
L
G
K
P
E
D
I
A
N
A
Y
L
F
L
A
S
H
E
S
D
Y
V
N
G
H
V
L
H
V
D
G
G
I
M
-------------------
22
PsiBlast_CBE
83.97
41%
-48
- C2 -
4NBU
1
?
C:
[9-249]
-
S
R
L
Q
D
K
V
A
I
I
T
G
A
A
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
V
I
A
D
F
N
E
A
-
A
G
K
E
A
V
E
A
---
N
P
G
V
V
-
F
I
R
V
D
V
S
D
R
E
S
V
H
R
L
V
E
N
V
A
E
R
F
G
K
I
D
I
L
I
N
N
A
G
I
T
R
D
S
--
M
L
S
K
M
T
V
D
Q
F
Q
Q
V
I
N
V
N
L
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
A
E
Q
--
G
K
G
-
K
I
I
N
T
S
S
V
T
G
T
Y
G
N
V
G
Q
--
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
L
A
R
K
G
--
I
N
V
N
A
V
A
P
G
F
T
E
T
A
M
V
--------
A
E
V
P
E
K
V
----
I
E
K
M
K
A
--
Q
V
P
M
G
R
L
G
K
P
E
D
I
A
N
A
Y
L
F
L
A
S
H
E
S
D
Y
V
N
G
H
V
L
H
V
D
G
G
I
M
-------------------
117
HHSearch
83.56
32%
-60
- C2 -
4J2H
7
?
A:
[8-256]
-
F
D
L
S
G
R
R
A
L
V
T
G
A
S
R
G
I
G
Q
S
I
A
V
A
L
A
E
A
G
A
H
V
A
V
T
A
R
T
V
E
-
G
L
A
E
T
R
A
L
I
E
K
T
G
R
R
A
V
A
L
A
Q
D
V
R
D
V
E
A
C
A
S
V
T
R
A
A
A
E
G
L
G
G
L
D
I
L
V
N
N
A
G
F
E
N
V
-
R
-
P
S
F
D
V
D
E
A
L
W
D
T
I
V
S
T
N
L
K
G
A
F
F
C
A
Q
A
A
G
R
I
M
A
D
A
N-
G
-
G
-
A
I
V
N
L
C
S
L
T
S
Y
V
G
I
P
T
A
--
V
P
Y
G
A
S
K
S
G
L
L
G
V
T
R
A
L
A
T
E
W
A
A
H
N
--
I
R
V
N
A
I
A
P
G
Y
F
R
T
A
M
T
A
G
F
Y
E
D
------
E
D
W
----
Q
S
R
M
L
E
--
K
I
P
Q
R
R
F
G
K
E
S
D
I
G
G
V
A
V
F
L
C
S
D
A
A
A
Y
I
T
G
H
C
I
P
A
D
G
G
Y
L
A
S
-----------------
3
PsiBlast_PDB
83.43
39%
-81
- C2 -
4I5G
-
?
A:
[3-246]
--
R
L
L
N
K
T
A
V
I
T
G
G
G
S
G
I
G
L
A
T
A
K
R
F
V
A
E
G
A
Y
V
F
I
V
D
V
S
R
K
-
E
L
E
Q
A
A
A
E
I
G
R
N
---
V
T
A
V
K
A
D
V
T
K
L
E
D
L
D
R
L
Y
A
I
V
R
E
Q
R
G
S
I
D
V
L
F
N
N
A
G
A
I
E
Q
K
--
T
L
E
E
I
T
P
E
H
Y
D
R
T
F
D
V
N
V
R
G
L
I
F
T
V
Q
K
A
L
P
L
-
L
R
D
--
G
-
G
-
S
V
I
L
T
S
S
V
A
G
V
L
G
L
Q
A
H
--
D
T
Y
S
A
A
K
A
A
V
R
S
L
A
R
T
W
T
T
E
L
K
G
R
S
--
I
R
V
N
A
V
S
P
G
A
I
D
T
P
----------------------
A
K
F
A
A
--
A
T
P
L
G
R
V
G
R
P
E
E
L
A
A
A
V
L
F
L
A
S
D
D
S
S
Y
V
A
G
I
E
L
F
V
D
G
G
L
--------------------
2
PsiBlast_PDB
83.43
40%
-50
- C2 -
4DQX
-
?
A:
[25-268]
---
L
N
Q
R
V
C
I
V
T
G
G
G
S
G
I
G
R
A
T
A
E
L
F
A
K
N
G
A
Y
V
V
V
A
D
V
N
E
D
-
A
A
V
R
V
A
N
E
I
---
G
S
K
A
F
G
V
R
V
D
V
S
S
A
K
D
A
E
S
M
V
E
K
T
T
A
K
W
G
R
V
D
V
L
V
N
N
A
G
F
G
T
T
G
--
N
V
V
T
I
P
E
E
T
W
D
R
I
M
S
V
N
V
K
G
I
F
L
C
S
K
Y
V
I
P
V
M
R
R
N
--
G
-
G
G
S
I
I
N
T
T
S
Y
T
A
T
S
A
I
A
D
R
--
T
A
Y
V
A
S
K
G
A
I
S
S
L
T
R
A
M
A
M
D
H
A
K
E
G
--
I
R
V
N
A
V
A
P
G
T
I
D
S
P
Y
F
T
K
I
F
A
--
E
A
K
D
P
A
K
L
----
R
S
D
F
N
A
--
R
A
V
M
D
R
M
G
T
A
E
E
I
A
E
A
M
L
F
L
A
S
D
R
S
R
F
A
T
G
S
I
L
T
V
D
G
G
---------------------
14
PsiBlast_PDB
82.89
37%
-61
- C2 -
3O03
3
?
A:
[32-284]
---
L
K
G
K
I
A
L
V
T
G
A
S
Y
G
I
G
F
A
I
A
S
A
Y
A
K
A
G
A
T
I
V
F
N
D
I
N
Q
E
-
L
V
D
R
G
M
A
A
Y
K
A
A
G
I
N
A
H
G
Y
V
C
D
V
T
D
E
D
G
I
Q
A
M
V
A
Q
I
E
S
E
V
G
I
I
D
I
L
V
N
N
A
G
I
I
R
R
V
P
-
M
I
-
E
M
T
A
A
Q
F
R
Q
V
I
D
I
D
L
N
A
P
F
I
V
S
K
A
V
I
P
S
M
I
K
K
--
G
H
G
-
K
I
I
N
I
C
S
M
M
S
E
L
G
R
E
T
V
--
S
A
Y
A
A
A
K
G
G
L
K
M
L
T
K
N
I
A
S
E
Y
G
E
A
N
--
I
Q
C
N
G
I
G
P
G
Y
I
A
T
P
Q
T
------------
H
P
F
----
D
Q
F
I
I
A
--
K
T
P
A
A
R
W
G
E
A
E
D
L
M
G
P
A
V
F
L
A
S
D
A
S
N
F
V
N
G
H
I
L
Y
V
D
G
G
I
L
A
Y
-----------------
21
PsiBlast_CBE
82.82
41%
-48
- C2 -
4NBU
2
?
D:
[9-249]
-
S
R
L
Q
D
K
V
A
I
I
T
G
A
A
N
G
I
G
L
E
A
A
R
V
F
M
K
E
G
A
K
V
V
I
A
D
F
N
E
A
-
A
G
K
E
A
V
E
A
---
N
P
G
V
V
-
F
I
R
V
D
V
S
D
R
E
S
V
H
R
L
V
E
N
V
A
E
R
F
G
K
I
D
I
L
I
N
N
A
G
I
T
R
D
S
--
M
L
S
K
M
T
V
D
Q
F
Q
Q
V
I
N
V
N
L
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
A
E
Q
--
G
K
G
-
K
I
I
N
T
S
S
V
T
G
T
Y
G
N
V
G
Q
--
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
L
A
R
K
G
--
I
N
V
N
A
V
A
P
G
F
T
E
T
A
M
V
--------
A
E
V
P
E
K
V
----
I
E
K
M
K
A
--
Q
V
P
M
G
R
L
G
K
P
E
D
I
A
N
A
Y
L
F
L
A
S
H
E
S
D
Y
V
N
G
H
V
L
H
V
D
G
G
I
M
-------------------
111
HHSearch
82.75
36%
-52
- C2 -
3TZQ
1
?
B:
[7-256]
-
A
E
L
E
N
K
V
A
I
I
T
G
A
C
G
G
I
G
L
E
T
S
R
V
L
A
R
A
G
A
R
V
V
L
A
D
L
P
E
T
-
D
L
A
G
A
A
A
S
V
---
G
R
G
A
V
H
H
V
V
D
L
T
N
E
V
S
V
R
A
L
I
D
F
T
I
D
T
F
G
R
L
D
I
V
D
N
N
A
A
H
S
D
P
A
D
M
L
V
T
Q
M
T
V
D
V
W
D
D
T
F
T
V
N
A
R
G
T
M
L
M
C
K
Y
A
I
P
R
L
I
S
A
G-
G
-
G
-
A
I
V
N
I
S
S
A
T
A
H
A
A
Y
D
M
S
--
T
A
Y
A
C
T
K
A
A
I
E
T
L
T
R
Y
V
A
T
Q
Y
G
R
H
G
--
V
R
C
N
A
I
A
P
G
L
V
R
T
P
R
L
E
---
P
Q
-------
P
I
----
V
D
I
F
A
T
--
H
H
L
A
G
R
I
G
E
P
H
E
I
A
E
L
V
C
F
L
A
S
D
R
A
A
F
I
T
G
Q
V
I
A
A
D
S
G
L
L
A
H
L
P
G
--------------
10
PsiBlast_PDB
82.47
37%
-55
- C2 -
3VTZ
-
?
A:
[2-247]
-
E
E
F
T
D
K
V
A
I
V
T
G
G
S
S
G
I
G
L
A
V
V
D
A
L
V
R
Y
G
A
K
V
V
--
S
V
S
L
D
-
E
----------
D
V
N
V
S
D
H
F
K
I
D
V
T
N
E
E
E
V
K
E
A
V
E
K
T
T
K
K
Y
G
R
I
D
I
L
V
N
N
A
G
I
E
Q
Y
S
--
P
L
H
L
T
P
T
E
I
W
R
R
I
I
D
V
N
V
N
G
S
Y
L
M
A
K
Y
T
I
P
V
M
L
A
I
--
G
H
G
-
S
I
I
N
I
A
S
V
Q
S
Y
A
A
T
K
N
A
--
A
A
Y
V
T
S
K
H
A
L
L
G
L
T
R
S
V
A
I
D
Y
A
P
K
---
I
R
C
N
A
V
C
P
G
T
I
M
T
P
M
V
I
K
A
A
---
K
M
E
V
G
E
D
E
N
A
V
E
R
K
I
E
E
W
G
R
Q
H
P
M
G
R
I
G
R
P
E
E
V
A
E
V
V
A
F
L
A
S
D
R
S
S
F
I
T
G
A
C
L
T
V
D
G
G
L
L
S
------------------
43
PsiBlast_CBE
82.36
37%
-83
- C2 -
4I5E
1
?
G:
[16-259]
--
R
L
L
N
K
T
A
V
I
T
G
G
N
S
G
I
G
L
A
T
A
K
R
F
V
A
E
G
A
Y
V
F
I
V
G
R
R
R
K
-
E
L
E
Q
A
A
A
E
I
G
R
N
---
V
T
A
V
K
A
D
V
T
K
L
E
D
L
D
R
L
Y
A
I
V
R
E
Q
R
G
S
I
D
V
L
F
A
N
S
G
A
I
E
Q
K
--
T
L
E
E
I
T
P
E
H
Y
D
R
T
F
D
V
N
V
R
G
L
I
F
T
V
Q
K
A
L
P
L
-
L
R
D
--
G
-
G
-
S
V
I
L
T
S
S
V
A
G
V
L
G
L
Q
A
H
--
D
T
Y
S
A
A
K
A
A
V
R
S
L
A
R
T
W
T
T
E
L
K
G
R
S
--
I
R
V
N
A
V
S
P
G
A
I
D
T
P
I
I
E
N
Q
V
S
T
--
Q
E
E
A
D
E
L
----
R
A
K
F
A
A
--
A
T
P
L
G
R
V
G
R
P
E
E
L
A
A
A
V
L
F
L
A
S
D
D
S
S
Y
V
A
G
I
E
L
F
V
D
G
G
L
--------------------
42
PsiBlast_CBE
82.15
37%
-82
- C2 -
4I5E
1
?
H:
[16-259]
--
R
L
L
N
K
T
A
V
I
T
G
G
N
S
G
I
G
L
A
T
A
K
R
F
V
A
E
G
A
Y
V
F
I
V
G
R
R
R
K
-
E
L
E
Q
A
A
A
E
I
G
R
N
---
V
T
A
V
K
A
D
V
T
K
L
E
D
L
D
R
L
Y
A
I
V
R
E
Q
R
G
S
I
D
V
L
F
A
N
S
G
A
I
E
Q
K
--
T
L
E
E
I
T
P
E
H
Y
D
R
T
F
D
V
N
V
R
G
L
I
F
T
V
Q
K
A
L
P
L
-
L
R
D
--
G
-
G
-
S
V
I
L
T
S
S
V
A
G
V
L
G
L
Q
A
H
--
D
T
Y
S
A
A
K
A
A
V
R
S
L
A
R
T
W
T
T
E
L
K
G
R
S
--
I
R
V
N
A
V
S
P
G
A
I
D
T
P
I
I
E
N
Q
V
S
T
--
Q
E
E
A
D
E
L
----
R
A
K
F
A
A
--
A
T
P
L
G
R
V
G
R
P
E
E
L
A
A
A
V
L
F
L
A
S
D
D
S
S
Y
V
A
G
I
E
L
F
V
D
G
G
L
--------------------
25
PsiBlast_CBE
82.11
40%
-50
- C2 -
4NBT
1
?
C:
[2-238]
-
K
K
L
E
G
K
V
A
V
I
T
G
G
A
K
G
L
G
Q
A
I
A
L
A
Y
A
E
E
G
A
K
V
I
A
G
D
L
G
D
----------
L
T
Y
S
H
P
N
V
E
G
M
Y
L
N
V
T
D
V
T
G
V
E
K
F
Y
Q
S
V
I
D
K
Y
G
K
I
D
I
L
V
N
N
A
G
I
T
K
D
A
--
M
T
R
K
M
T
E
A
Q
W
D
A
V
I
D
V
N
L
K
G
V
F
N
L
T
R
L
V
G
P
Q
M
Q
T
N
--
G
Y
G
-
S
I
I
N
I
S
S
V
V
G
V
F
G
N
I
G
Q
--
A
N
Y
A
A
T
K
A
G
V
I
G
L
T
M
T
W
A
K
E
F
A
L
K
G
AN
V
R
V
N
A
I
A
P
G
Y
I
M
T
D
I
L
K
----
T
V
P
Q
D
L
L
D
K
F
----
A
A
------
L
T
M
L
N
R
L
G
Q
P
E
E
I
A
K
V
A
L
F
L
A
S
D
D
A
S
Y
V
T
G
Q
T
I
N
V
N
G
G
M
--------------------
45
PsiBlast_CBE
81.84
37%
-84
- C2 -
4I5E
2
?
E:
[16-259]
--
R
L
L
N
K
T
A
V
I
T
G
G
N
S
G
I
G
L
A
T
A
K
R
F
V
A
E
G
A
Y
V
F
I
V
G
R
R
R
K
-
E
L
E
Q
A
A
A
E
I
G
R
N
---
V
T
A
V
K
A
D
V
T
K
L
E
D
L
D
R
L
Y
A
I
V
R
E
Q
R
G
S
I
D
V
L
F
A
N
S
G
A
I
E
Q
K
--
T
L
E
E
I
T
P
E
H
Y
D
R
T
F
D
V
N
V
R
G
L
I
F
T
V
Q
K
A
L
P
L
-
L
R
D
--
G
-
G
-
S
V
I
L
T
S
S
V
A
G
V
L
G
L
Q
A
H
--
D
T
Y
S
A
A
K
A
A
V
R
S
L
A
R
T
W
T
T
E
L
K
G
R
S
--
I
R
V
N
A
V
S
P
G
A
I
D
T
P
I
I
E
N
Q
V
S
T
--
Q
E
E
A
D
E
L
----
R
A
K
F
A
A
--
A
T
P
L
G
R
V
G
R
P
E
E
L
A
A
A
V
L
F
L
A
S
D
D
S
S
Y
V
A
G
I
E
L
F
V
D
G
G
L
--------------------
13
PsiBlast_PDB
81.63
37%
-58
- C2 -
3CXR
-
?
A:
[12-264]
---
L
K
G
K
I
A
L
V
T
G
A
S
Y
G
I
G
F
A
I
A
S
A
Y
A
K
A
G
A
T
I
V
F
N
D
I
N
Q
E
-
L
V
D
R
G
M
A
A
Y
K
A
A
G
I
N
A
H
G
Y
V
C
D
V
T
D
E
D
G
I
Q
A
M
V
A
Q
I
E
S
E
V
G
I
I
D
I
L
V
N
N
A
G
I
I
R
R
V
P
-
M
I
-
E
M
T
A
A
Q
F
R
Q
V
I
D
I
D
L
N
A
P
F
I
V
S
K
A
V
I
P
S
M
I
K
K
--
G
H
G
-
K
I
I
N
I
C
S
M
M
S
E
L
G
R
E
T
V
--
S
A
Y
A
A
A
K
G
G
L
K
M
L
T
K
N
I
A
S
E
Y
G
E
A
N
--
I
Q
C
N
G
I
G
P
G
Y
I
A
T
P
Q
T
A
P
L
R
E
L
------
H
P
F
----
D
Q
F
I
I
A
--
K
T
P
A
A
R
W
G
E
A
E
D
L
M
G
P
A
V
F
L
A
S
D
A
S
N
F
V
N
G
H
I
L
Y
V
D
G
G
I
L
A
Y
-----------------
24
PsiBlast_CBE
81.47
40%
-49
- C2 -
4NBT
1
?
D:
[2-238]
-
K
K
L
E
G
K
V
A
V
I
T
G
G
A
K
G
L
G
Q
A
I
A
L
A
Y
A
E
E
G
A
K
V
I
A
G
D
L
G
D
----------
L
T
Y
S
H
P
N
V
E
G
M
Y
L
N
V
T
D
V
T
G
V
E
K
F
Y
Q
S
V
I
D
K
Y
G
K
I
D
I
L
V
N
N
A
G
I
T
K
D
A
--
M
T
R
K
M
T
E
A
Q
W
D
A
V
I
D
V
N
L
K
G
V
F
N
L
T
R
L
V
G
P
Q
M
Q
T
N
--
G
Y
G
-
S
I
I
N
I
S
S
V
V
G
V
F
G
N
I
G
Q
--
A
N
Y
A
A
T
K
A
G
V
I
G
L
T
M
T
W
A
K
E
F
A
L
K
G
AN
V
R
V
N
A
I
A
P
G
Y
I
M
T
D
I
L
K
----
T
V
P
Q
D
L
L
D
K
F
----
A
A
------
L
T
M
L
N
R
L
G
Q
P
E
E
I
A
K
V
A
L
F
L
A
S
D
D
A
S
Y
V
T
G
Q
T
I
N
V
N
G
G
M
--------------------
122
HHSearch
81.40
36%
-8
- C2 -
1GEE
1
DHG_BACME
A:
[3-253]
-
K
D
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
N
Y
R
S
K
E
D
E
A
N
S
V
L
E
E
I
K
K
V
G
G
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
G
L
E
N
P
-
V
-
S
S
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
DI
K
-
G
-
T
V
I
N
M
S
S
V
H
E
K
I
P
W
P
L
F
--
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
--
I
R
V
N
N
I
G
P
G
A
I
N
T
P
I
N
A
E
K
F
A
D
P
------
E
Q
----
R
A
D
V
E
S
--
M
I
P
M
G
Y
I
G
E
P
E
E
I
A
A
V
A
A
W
L
A
S
S
E
A
S
Y
V
T
G
I
T
L
F
A
D
G
G
M
T
L
Y
-----------------
108
HHSearch
77.94
30%
-96
- C2 -
3GED
4
?
A:
[2-230]
-----
N
R
G
V
I
V
T
G
G
G
H
G
I
G
K
Q
I
C
L
D
F
L
E
A
G
D
K
V
C
F
I
D
I
D
E
K
-
R
S
A
D
F
A
K
E
----
R
P
N
L
F
Y
F
H
G
D
V
A
D
P
L
T
L
K
K
F
V
E
Y
A
M
E
K
L
Q
R
I
D
V
L
V
N
N
A
C
R
G
S
K
-
G
-
I
L
S
S
L
L
Y
E
E
F
D
Y
I
L
S
V
G
L
K
A
P
Y
E
L
S
R
L
C
R
D
E
L
I
K
N
--
K
-
G
-
R
I
I
N
I
A
S
T
R
A
F
Q
S
E
P
D
S
--
E
A
Y
A
S
A
K
G
G
I
V
A
L
T
H
A
L
A
M
S
L
G
P
-
D
--
V
L
V
N
C
I
A
P
G
W
I
N
V
T
---
E
F
T
Q
--------
E
--------
D
C
A
--
A
I
P
A
G
K
V
G
T
P
K
D
I
S
N
M
V
L
F
L
C
Q
Q
--
D
F
I
T
G
E
T
I
I
V
D
G
G
M
S
-------------------
109
HHSearch
75.86
33%
-41
- C2 -
4FN4
3
?
A:
[3-252]
-
Q
S
L
K
N
K
V
V
I
V
T
G
A
G
S
G
I
G
R
A
I
A
K
K
F
A
L
N
D
S
I
V
V
A
V
E
L
L
E
D
-
R
L
N
Q
I
V
Q
E
L
R
G
M
G
K
E
V
L
G
V
K
A
D
V
S
K
K
K
D
V
E
E
F
V
R
R
T
F
E
T
Y
S
R
I
D
V
L
C
N
N
A
G
I
M
D
G
V
T
-
P
V
A
E
V
S
D
E
L
W
E
R
V
L
A
V
N
L
Y
S
A
F
Y
S
S
R
A
V
I
P
I
M
L
K
Q
G-
K
-
G
-
V
I
V
N
T
A
S
I
A
G
I
R
G
G
F
A
G
--
A
P
Y
T
V
A
K
H
G
L
I
G
L
T
R
S
I
A
A
H
Y
G
D
Q
G
--
I
R
A
V
A
V
L
P
G
T
V
K
T
N
I
G
L
G
S
S
K
P
S
E
L
----
G
M
----
R
T
L
T
K
L
--
M
S
L
S
S
R
L
A
E
P
E
D
I
A
N
V
I
V
F
L
A
S
D
E
A
S
F
V
N
G
D
A
V
V
V
D
G
G
L
T
-------------------