@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu39880: (2016-08-06 )
MSAVTESVLESIISPVTMSEFLEEYWPVKPLVARGEVERFTSIPGFEKVRTLENVLAIYNNPVMVVGDAVIEESEGITDRFLVSPAEALEWYEKGAALEFDFTDLFIPQVRRWIEKLKAELRLPAGTSSKAIVYAAKNGGGFKAHFDAYTNLIFQIQGEKTWKLAKNENVSNPMQHYDLSEAPYYPDDLQSYWKGDPPKEDLPDAEIVNLTPGTMLYLPRGLWHSTKSDQATLALNITFGQPAWLDLMLAALRKKLISDNRFRELAVNHQSLHESSKSELNGYLESLIQTLSENAETLTPEQIFQSQDSDFDPYQSTQLVFRQLLTSYKF
Atome Classification :
(20 SA)
----.........10.......-.20.....-...30.....----..----.40.-.......50........60--.-.----....----.--..--70.--.--..-.--.--.-.80........90..-..----....100..-------.----.....110....----.----..120----...--....130......-.140........150.......160.......170.-....-.---------.------------------------180--------------......-...190.......200.......210...-....220....---..----.230-.......---..240--.-.-------------......-.250..----..----...260---------.......270.......280.......290.......300.......310------------.......320.......330-----------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----M
S
A
V
T
E
S
V
L
E
S
I
ISP
V
T
M
-
S
E
F
L
E
E
YW-PVKPLVARG
E
----
V
E
----
R
FTS-IP
G
F
E
K
V
R
T
L
E
N
V
L
A
I
YN---N-
P
----
V
M
V
V
----
G
--
D
A
--
V
IE--E--SE-G--I--
T
-
D
RFLV
S
P
A
E
A
L
E
W
Y
E-KG----A
A
L
E
F
-
D
F
T
-------
D
----
L
F
I
P
Q
V
R
R
W
I
E
K
----
L
----
K
A
E
LR----LPA--GTSS
K
A
I
V
Y
A
AKN-GG-G
F
K
A
H
F
D
A
Y
T
N
L
I
F
Q
IQG
E
K
T
W
K
LAKNENVSN
P
-
M
Q
HY-D---------L------------------------S----------------EAPYY
P
-
D
D
L
Q
S
Y
WKGDPPKEDLPDA
E
I
V
NLTPG
T
M
-
L
YLPRGLWHST---KS----D
Q
---
A
T
L
A
L
N
I
---TFG----
Q
-
P
-------------
A
W
L
D
L
M
-
L
A
A
L
R
K
----
K
L----ISDN
R
F
---------
R
E
L
A
V
N
H
Q
S
L
H
ES
S
K
S
E
L
N
G
Y
L
E
S
L
I
Q
T
L
SENAETL
T
P
E
Q
I
F
QSQDSDFD------------P
Y
Q
S
T
Q
L
V
F
R
Q
L
L
T
SYKF-------------------------------------------------------------------------
23
HHSearch
94.20
100%
-91
- C3 -
1VRB
1
YXBC_BACSU
A:
[20-338]
-----------
V
L
E
S
I
I
S
P
V
T
M
-
S
E
F
L
E
E
Y
W
-
P
V
K
P
L
V
A
R
G
E
----
V
E
----
R
F
T
S
-
I
P
G
F
E
K
V
R
T
L
E
N
V
L
A
I
Y
N
---
N
-
P
----
V
M
V
V
-------------------------------
R
F
L
V
S
P
A
E
A
L
E
W
Y
E
-
K
G
----
A
A
L
E
F
-
D
F
T
-------
D
----
L
F
I
P
Q
V
R
R
W
I
E
K
----
L
----
K
A
E
L
R
----
L
P
A
--
G
T
S
S
K
A
I
V
Y
A
A
K
N
-
G
G
-
G
F
K
A
H
F
D
A
Y
T
N
L
I
F
Q
I
Q
G
E
K
T
W
K
L
A
K
N
E
N
V
S
N
P
-
M
Q
H
Y
-
D
---------
L
------------------------
S
--------------------
Y
P
-
D
D
L
Q
S
Y
W
K
G
D
P
P
K
E
D
L
P
D
A
E
I
V
N
L
T
P
G
T
M
-
L
Y
L
P
R
G
L
W
H
S
T
---
K
S
----
D
Q
---
A
T
L
A
L
N
I
---
T
F
G
----
Q
-
P
-------------
A
W
L
D
L
M
-
L
A
A
L
R
K
----
K
L
----
I
S
D
N
R
F
---------
R
E
L
A
V
N
H
Q
S
L
H
E
S
S
K
S
E
L
N
G
Y
L
E
S
L
I
Q
T
L
S
E
N
A
E
T
L
T
P
E
Q
I
F
Q
S
Q
D
S
D
F
D
------------
P
Y
Q
S
T
Q
L
V
F
R
Q
L
L
T
-----------------------------------------------------------------------------
1
PsiBlast_PDB
93.79
98%
-91
- C3 -
1VRB
1
YXBC_BACSU
A:
[20-338]
-----------
V
L
E
S
I
I
S
P
V
T
M
-
S
E
F
L
E
E
Y
W
-
P
V
K
P
L
V
A
R
G
E
----
V
E
----
R
F
T
S
-
I
P
G
F
E
K
V
R
T
L
E
N
V
L
A
I
Y
N
---
N
-
P
----
V
M
V
V
-------------------------------
R
F
L
V
S
P
A
E
A
L
E
W
Y
E
-
K
G
----
A
A
L
E
F
-
D
F
T
-------
D
----
L
F
I
P
Q
V
R
R
W
I
E
K
----
L
----
K
A
E
L
R
----
L
P
A
--
G
T
S
S
K
A
I
V
Y
A
A
K
N
-
G
G
-
G
F
K
A
H
F
D
A
Y
T
N
L
I
F
Q
I
Q
G
E
K
T
W
K
L
A
K
N
E
N
V
S
N
P
-
M
Q
H
Y
-
D
---------
L
------------------------
S
--------------------
Y
P
-
D
D
L
Q
S
Y
W
K
G
D
P
P
K
E
D
L
P
D
A
E
I
V
N
L
T
P
G
T
M
-
L
Y
L
P
R
G
L
W
H
S
T
---
K
S
----
D
Q
---
A
T
L
A
L
N
I
---
T
F
G
----
Q
-
P
-------------
A
W
L
D
L
M
-
L
A
A
L
R
K
----
K
L
----
I
S
D
N
R
F
---------
R
E
L
A
V
N
H
Q
S
L
H
E
S
S
K
S
E
L
N
G
Y
L
E
S
L
I
Q
T
L
S
E
N
A
E
T
L
T
P
E
Q
I
F
Q
S
Q
D
S
D
F
D
------------
P
Y
Q
S
T
Q
L
V
F
R
Q
L
L
T
-----------------------------------------------------------------------------
45
Fugue
77.98
95%
16
- C3 -
1VRB
1
YXBC_BACSU
A:
[20-338]
-----------
V
L
E
S
I
I
S
P
V
T
-
M
S
E
F
L
E
E
Y
W
-
P
V
K
P
L
V
A
R
G
E
----
V
E
----
R
F
T
S
-
I
P
G
F
E
K
V
R
T
L
E
N
V
L
A
I
Y
N
---
N
-
P
----
V
-----------------------------
M
-
V
-
V
R
F
L
V
S
P
A
E
A
L
E
W
Y
E
-
K
G
----
A
A
L
E
F
-
D
F
T
-------
D
----
L
F
I
P
Q
V
R
R
W
I
E
K
----
L
----
K
A
E
L
R
----
L
P
A
--
G
T
S
S
K
A
I
V
Y
A
A
K
N
-
G
G
-
G
F
K
A
H
F
D
A
Y
T
N
L
I
F
Q
I
Q
G
E
K
T
W
K
L
A
K
N
E
N
V
S
N
P
M
Q
H
Y
D
-------------------------------------------------------
L
S
Y
P
-
D
D
L
Q
S
Y
W
K
G
D
P
P
K
E
D
L
P
D
A
E
I
V
-
N
L
T
P
G
T
M
L
Y
L
P
R
G
L
W
H
S
T
---
K
S
----
D
Q
---
A
T
L
A
L
N
I
---
T
F
G
----
Q
-
P
-------------
A
W
L
D
L
-
M
L
A
A
L
R
K
----
K
L
----
I
S
D
N
R
F
---------
R
E
L
A
V
N
H
Q
S
L
H
E
S
S
K
S
E
L
N
G
Y
L
E
S
L
I
Q
T
L
S
E
N
A
E
T
L
T
P
E
Q
I
F
Q
S
Q
D
S
D
F
D
------------
P
Y
Q
S
T
Q
L
V
F
R
Q
L
L
T
-----------------------------------------------------------------------------
9
PsiBlast_PDB
48.61
24%
-44
- C3 -
4CSW
3
?
A:
[19-245]
-------------
E
T
I
L
G
G
L
A
P
-
E
E
F
L
A
N
Y
W
-
Q
K
R
P
L
L
I
R
--------------
Q
A
-
L
P
G
F
R
S
P
I
T
P
E
E
L
---------------------------
A
--
G
L
A
--
C
--
E
E
-
G
--
V
--
T
-
A
R
L
I
L
E
K
G
G
A
Y
P
W
E
V
-
R
Y
----
G
P
F
E
P
E
D
F
V
ALPPTH
W
T
----
L
L
V
Q
E
V
D
R
L
V
P
E
----
V
----
A
A
L
L
E
T
V
RF
V
P
N
--
W
R
L
D
D
I
M
V
S
Y
A
P
E
-
G
G
-
T
V
G
A
H
I
D
N
Y
D
V
F
L
V
Q
A
W
G
R
R
R
W
Q
I
N
H
-----
R
P
-
V
E
R
E
-
E
---------
L
------------------------------------------
V
P
G
L
E
-
V
R
L
L
A
H
F
E
--------
P
D
A
E
W
I
-
L
E
P
G
D
V
-
L
Y
L
P
P
R
I
P
H
Y
G
---
V
A
----
L
E
---
D
C
M
T
F
S
I
---
G
F
R
----
A
-
P
D
Q
A
E
L
A
E
A
M
P
R
M
A
A
W
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
48.23
24%
-48
- C3 -
4CUG
5
?
A:
[19-245]
-------------
E
T
I
L
G
G
L
A
P
-
E
E
F
L
A
N
Y
W
-
Q
K
R
P
L
L
I
R
--------------
Q
A
-
L
P
G
F
R
S
P
I
T
P
E
E
L
---------------------------
A
--
G
L
A
--
C
--
E
E
-
G
--
V
--
T
-
A
R
L
I
L
E
K
G
G
A
Y
P
W
E
V
-
R
Y
----
G
P
F
E
P
E
D
F
V
A
LPPTH
W
T
----
L
L
V
Q
E
V
D
R
L
V
P
E
----
V
----
A
A
L
L
E
T
V
RF
V
P
N
--
W
R
L
D
D
I
M
V
S
Y
A
P
E
-
G
G
-
T
V
G
A
H
I
D
N
Y
D
V
F
L
V
Q
A
W
G
R
R
R
W
Q
I
N
H
-----
R
P
-
V
E
R
E
-
E
---------
L
------------------------------------------
V
P
G
L
E
-
V
R
L
L
A
H
F
E
--------
P
D
A
E
W
I
-
L
E
P
G
D
V
-
L
Y
L
P
P
R
I
P
H
Y
G
---
V
A
----
L
E
---
D
C
M
T
F
S
I
---
G
F
R
----
A
-
P
D
Q
A
E
L
A
E
A
MPR
M
A
A
W
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
48.14
20%
7
- C3 -
4CCJ
1
NO66_HUMAN
A:
[21-273]
--------
A
A
R
L
F
E
W
L
I
A
P
M
P
P
-
D
H
F
Y
R
R
L
W
-
E
R
E
A
V
L
V
R
R
Q
D---
H
T
----
Y
Y
Q
G
-
L
F
S
---
T
A
D
L
D
S
M
L
R
N
E
E
---
V
-
Q
FGQH
L
D
A
A
--------
R
--
Y
I
N
--
G
--
R
R
E
T
--
L
--
N
-
P
P
G
R
A
L
P
A
A
A
W
S
L
Y
Q
-
A
G
----
C
S
L
R
L
-
L
C
P
-------
Q
----
A
F
S
T
T
V
W
Q
F
L
A
V
----
L
----
Q
E
Q
F
G
----
S
M
A
--
G
S
----
N
V
Y
L
T
P
P
N
S
Q
-
G
F
A
P
H
Y
D
D
I
E
A
F
V
L
Q
L
E
G
R
K
L
W
R
V
Y
R
P
R
A
P
T
E
E
-
L
A
L
T
-
S
---------
S
------------------------
P
------------------------
N
F
S
-------
Q
D
D
L
G
E
P
V
L
Q
T
V
L
E
P
G
D
L
-
L
Y
F
P
R
G
F
I
H
Q
A
---
E
C
----
Q
D
G
V
-
H
S
L
H
L
T
L
---
S
T
Y
----
Q
R
N
-------------
T
W
G
D
F
L
-
E
A
I
L
P
L
A
V
Q
A
A
M
----
E
E
N
V
E
F
---------
R
R
G
L
-----------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
47.69
19%
-27
- C3 -
4QSZ
-
JMJD7_MOUSE (first)
A:
[398-669]
----------
R
V
V
P
Y
L
D
E
P
P
S
P
-
L
C
F
Y
R
D
W
V
C
P
N
R
P
C
I
I
R
N
A
----
L
Q
-------
H
-
W
P
A
L
Q
K
W
S
-
L
S
Y
L
R
A
T
V
G
---
S
T
E
----
V
S
V
A
----
V
T
P
D
G
--
Y
A
D
AV
R
--
G
D
-
R
F
V
M
--
P
-
A
E
R
R
L
P
I
S
H
V
L
D
V
L
E
-
G
R
A
Q
H
P
G
V
L
Y
V
-
Q
K
-CSNL---
P
----
T
E
L
P
Q
L
L
S
D
I
E
S
----
H
V
P
W
A
S
E
S
L
G
----
K
-----
M
P
D
A
V
N
F
W
L
G
D
A
-
S
A
-
V
T
S
L
H
K
D
H
Y
E
N
L
Y
C
V
V
S
G
E
K
H
F
L
L
H
P
P
S
D
R
P
F
I
-
P
Y
N
L
Y
T
---------
P
A
T
Y
Q
L
T
EEG
T
F
R
V
V
D
EEAM
E
K
V
P
W
I
----------------
P
L
D
P
L
A
-
P
D
L
T
Q
-----
Y
P
S
Y
S
Q
A
Q
A
L
H
C
T
V
R
A
G
E
M
-
L
Y
L
P
A
L
W
F
H
H
V
---
Q
Q
----
S
H
---
G
C
I
A
V
N
F
---
W
Y
D
----
M
-
E
-------------
Y
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
47.06
23%
2
- C3 -
4BXF
3
MINA_HUMAN
A:
[16-281]
---------
S
S
L
F
E
S
L
I
S
P
I
K
T
-
E
T
F
F
K
E
F
W
-
E
Q
K
P
L
L
I
Q
R
D
----
D
P
A
L
A
T
Y
Y
G
S
-
L
F
K
---
L
T
D
L
K
S
L
C
S
R
G
M
Y
Y
G
R
-
D
----
V
N
V
C
----
R
-------
C
V
--
N
--
G
K
-
K
K
V
L
--
N
-
K
D
G
K
A
H
F
L
Q
L
R
K
D
F
D
Q
K
R
----
A
T
I
Q
F
-
H
Q
P
-------
Q
----
R
F
K
D
E
L
W
R
I
Q
E
K
----
L
----
E
C
Y
F
G
----
S
L
V
--
G
----
S
N
V
Y
I
T
P
A
-
G
S
Q
G
L
P
P
H
Y
D
D
V
E
V
F
I
L
Q
L
E
G
E
K
H
W
R
L
Y
H
P
T
V
-
P
---
L
A
R
E
-
C
---------
S
------------------------
V
------------------------
E
--------
A
E
E
R
I
G
R
P
V
H
E
F
M
L
K
P
G
D
L
-
L
Y
F
P
R
G
T
I
H
Q
A
---
D
T
----
P
A
GL
A
H
S
T
H
V
T
I
---
S
T
Y
----
Q
N
N
-------------
S
W
G
D
F
L
-
L
D
T
I
S
G
----
L
V
F
D
TA
K
E
D
V
E
L
---------
R
T
G
I
-
P
R
Q
-------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
44.86
19%
-25
- C3 -
4QU2
2
JMJD7_MOUSE
A:
[30-300]
-----------
V
V
P
Y
L
D
E
P
P
S
P
-
L
C
F
Y
R
D
W
V
C
P
N
R
P
C
I
I
R
N
A
----
L
Q
-------
H
-
W
P
A
L
Q
K
W
S
-
L
S
Y
L
R
A
T
V
G
---
S
T
E
----
V
S
V
A
----
V
--
T
P
DG
Y
A
D
--
A
VR
G
D
-
R
--
F
VM
P
-
A
E
R
R
L
P
I
S
H
V
L
D
V
L
E
-
G
R
A
Q
H
P
G
V
L
Y
V
-
Q
K
Q
-------
C
SNLP
T
E
L
P
Q
L
L
S
D
I
E
S
HV
P
W
A
----
S
E
S
L
G
----
K
-----
M
P
D
A
V
N
F
W
L
G
D
A
-
S
A
-
V
T
S
L
H
K
D
H
Y
E
N
L
Y
C
V
V
S
G
E
K
H
F
L
L
H
P
P
S
D
R
P
F
I
-
P
Y
N
L
-
Y
T
P
A
T
Y
Q
L
T
E
E
------------------------
G
T
F
R
V
V
D
EEAM
E
K
V
P
W
I
P
L
D
P
L
A
-
P
D
L
T
Q
-----
Y
P
S
Y
S
Q
A
Q
A
L
H
C
T
V
R
A
G
E
M
-
L
Y
L
P
A
L
W
F
H
H
V
---
Q
Q
----
S
H
---
G
C
I
A
V
N
F
---
W
Y
D
----
M
-
E
-------------
Y
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
44.09
22%
18
- C3 -
4BXF
3
MINA_HUMAN
A:
[17-317]
----------
S
L
F
E
S
L
I
S
P
I
K
T
-
E
T
F
F
K
E
F
W
-
E
Q
K
P
L
L
I
Q
R
D
D
P
A
L
A
T
----
Y
Y
G
S
-
L
F
K
L
T
D
L
K
S
L
C
S
R
G
M
Y
Y
G
---
R
-
D
----
V
N
V
C
R
C
V
N
G
--
K
K
--
K
V
L
--
N
--
K
D
-
G
--
K
--
A
-
H
F
L
Q
L
R
K
----
D
F
D
Q
-
K
R
----
A
T
I
Q
F
-
H
Q
P
-------
Q
----
R
F
K
D
E
L
W
R
I
Q
E
K
----
L
----
E
C
Y
F
G
----
S
L
V
--
G
S
N
----
V
Y
I
T
P
A
-
G
S
Q
G
L
P
P
H
Y
D
D
V
E
V
F
I
L
Q
L
E
G
E
K
H
W
R
L
Y
---
H
P
T
V
P
-
L
A
R
E
-
C
---------
S
------------------------
V
----------------
E
A
---------
E
E
R
I
G
R
P
V
H
E
F
M
-------
L
K
P
G
D
L
-
L
Y
F
P
R
G
T
I
H
Q
A
---
D
T
P
A
GL
A
H
---
S
T
H
V
T
I
S
---
T
Y
Q
----
N
-
N
-------------
S
W
G
D
F
L
-
L
D
T
I
S
G
----
L
V
----
F
D
T
A
K
E
DVELRTGIP
R
Q
L
L
L
Q
V
E
S
T
T
V
A
T
R
-
R
L
S
G
F
L
R
T
L
A
D
R
L
E
G
T
K
E
L
L
S
S
D
------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
42.58
25%
-34
- C3 -
4CCJ
-
NO66_HUMAN
A:
[102-255]
-----------------------------------------------------------------------------------------------------------------------------
P
A
A
A
W
S
L
Y
Q
-
A
G
----
C
S
L
R
L
-
L
C
P
-------
Q
----
A
F
S
T
T
V
W
Q
F
L
A
V
----
L
----
Q
E
Q
F
G
----
S
M
A
--
G
S
N
---
V
Y
L
T
P
P
N
-
S
Q
-
G
F
A
P
H
Y
D
D
I
E
A
F
V
L
Q
L
E
G
R
K
L
W
R
V
Y
R
P
R
---
A
P
-
T
E
E
L
-
A
---------
L
------------------------
T
----------------
S
S
P
N
F
S
Q
D
D
L
-----
G
E
P
V
L
Q
T
V
-------
L
E
P
G
D
L
-
L
Y
F
P
R
G
F
I
H
Q
A
---
E
C
----
Q
D
---
G
V
H
S
L
H
L
T
L
S
T
Y
Q
----
R
-
N
-------------
T
W
G
D
F
L
-
E
A
I
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
41.87
25%
-33
- C3 -
4CCM
4
NO66_HUMAN
A:
[102-256]
-----------------------------------------------------------------------------------------------------------------------------
P
A
A
A
W
S
L
Y
Q
-
A
G
----
C
S
L
R
L
-
L
C
P
-------
Q
----
A
F
S
T
T
V
W
Q
F
L
A
V
----
L
----
Q
E
Q
F
G
----
S
M
A
--
G
S
N
---
V
Y
L
T
P
P
N
-
S
Q
-
G
F
A
P
H
Y
D
D
I
E
A
F
V
L
Q
L
E
G
R
K
L
W
R
V
Y
R
P
R
---
V
P
-
T
E
E
L
-
A
---------
L
------------------------
T
----------------
S
S
P
N
F
S
Q
D
D
L
-----
G
E
P
V
L
Q
T
V
-------
L
E
P
G
D
L
-
L
Y
F
P
R
G
F
I
H
Q
A
---
E
C
----
Q
D
---
G
V
H
S
L
H
L
T
L
S
T
Y
Q
----
R
-
N
-------------
T
W
G
D
F
L
-
E
A
I
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
41.80
25%
-32
- C3 -
4CCK
3
NO66_HUMAN
A:
[102-257]
-----------------------------------------------------------------------------------------------------------------------------
P
A
A
A
W
S
L
Y
Q
-
A
G
----
C
S
L
R
L
-
L
C
P
-------
Q
----
A
F
S
T
T
V
W
Q
F
L
A
V
----
L
----
Q
E
Q
F
G
----
S
M
A
--
G
S
N
---
V
Y
L
T
P
P
N
-
S
Q
-
G
F
A
P
H
Y
D
D
I
E
A
F
V
L
Q
L
E
G
R
K
L
W
R
V
Y
R
P
R
---
A
P
-
T
E
E
L
-
A
---------
L
------------------------
T
----------------
S
S
P
N
F
S
Q
D
D
L
-----
G
E
P
V
L
Q
T
V
-------
L
E
P
G
D
L
-
L
Y
F
P
R
G
F
I
H
Q
A
---
E
C
----
Q
D
---
G
V
H
S
L
H
L
T
L
S
T
Y
Q
----
R
-
N
-------------
T
W
G
D
F
L
-
E
A
I
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
41.32
19%
25
- C3 -
2XDV
12
MINA_HUMAN
A:
[7-442]
PSAL
N
F
D
S
P
S
S
L
F
E
S
L
I
S
P
I
K
T
-
E
T
F
F
K
E
F
W
-
E
Q
K
P
L
L
I
Q
R
D
----
D
P
----
A
L
A
T
Y
Y
G
S
L
F
K
L
T
D
L
K
S
L
C
----------------------------------------------------------
K
D
F
D
Q
-
K
R
----
A
T
I
Q
F
-
H
Q
P
-------
Q
----
R
F
K
D
E
L
W
R
I
Q
E
K
----
L
----
E
C
Y
F
G
----
S
L
V
-----
G
S
N
V
Y
I
T
P
A
G
-
S
Q
-
G
L
P
P
H
Y
D
D
V
E
V
F
I
L
Q
L
E
G
E
K
H
W
R
L
Y
H
P
---------------------------------------------------------------------
T
-
V
P
L
A
R
E
Y
S
V
E
A
E
E
R
I
G
R
P
V
H
E
F
M
L
K
P
G
D
L
-
L
Y
F
P
R
G
T
I
H
Q
A
D
T
P
A
G
----
L
A
---
H
S
T
H
V
T
I
---
S
T
Y
QNNS
W
-
G
-------------
D
F
L
L
D
T
-
I
S
G
L
V
F
----
D
T
----
A
K
E
D
V
E
---------
L
R
T
G
I
P
R
Q
L
L
L
Q
E
S
T
T
V
A
T
R
R
L
S
G
F
L
R
T
L
A
D
R
L
E
G
T
K
E
L
L
S
S
D
M
K
K
D
F
I
M
H
RLPPYSAKLPR
L
D
S
V
V
R
L
Q
F
K
D
H
I
V
L
T
V
L
PE
K
M
V
Y
I
Y
H
SLKNSRETHMMGNH
G
L
R
F
P
LSH
L
D
A
L
K
Q
I
W
N
SPAISVKDLKLTT
D
E
E
K
E
S
L
V
L
S
L
W
T
E
CLIQVV
26
HHSearch
41.22
16%
-28
- C3 -
4LIT
2
ROXA_ECOLI
A:
[36-253]
--------------
E
Y
Q
L
T
L
N
W
-
P
D
F
L
E
R
H
W
-
Q
K
R
P
V
V
L
K
R
G
----
F
N
-------
N
-
F
I
--
D
P
I
S
-
P
D
E
L
A
G
L
A
M
---
E
S
E
----
V
D
S
R
----
L
-------
V
S
--
H
--
Q
D
-
G
--
K
--
W
-
Q
V
S
H
G
P
F
E
S
Y
D
H
L
G
E
-
T
N
----
W
S
L
L
V
-
Q
A
V
-------
N
----
H
W
H
E
P
T
A
A
L
M
R
P
----
F
----
R
E
L
P
D
----
W
R
I
-----
D
D
L
M
I
S
F
S
V
P
-
G
G
-
G
V
G
P
H
L
D
Q
Y
D
V
F
I
I
Q
G
T
G
R
R
R
W
R
V
G
E
K
-------------------------------------------------------------------------
L
L
Q
V
-----
D
P
--
F
E
A
I
I
D
E
E
L
E
P
G
D
I
-
L
Y
I
P
P
G
F
P
H
E
G
---
Y
A
----
L
E
---
N
A
M
N
Y
S
V
---
G
F
R
----
A
-
P
-------------
N
T
R
E
L
I
-
S
G
F
A
D
Y
----
V
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
41.08
25%
-30
- C3 -
4CCN
3
NO66_HUMAN
A:
[102-256]
-----------------------------------------------------------------------------------------------------------------------------
P
A
A
A
W
S
L
Y
Q
-
A
G
----
C
S
L
R
L
-
C
S
P
-------
Q
----
A
F
S
T
T
V
W
Q
F
L
A
V
----
L
----
Q
E
Q
F
G
----
S
M
A
--
G
S
N
---
V
Y
L
T
P
P
N
-
S
Q
-
G
F
A
P
H
Y
D
D
I
E
A
F
V
L
Q
L
E
G
R
K
L
W
R
V
Y
R
P
R
---
A
P
-
T
E
E
L
-
A
---------
L
------------------------
T
----------------
S
S
P
N
F
S
Q
D
D
L
-----
G
E
P
V
L
Q
T
V
-------
L
E
P
G
D
L
-
L
Y
F
P
R
G
F
I
H
Q
A
---
E
C
----
Q
D
---
G
V
H
S
L
H
L
T
L
S
T
Y
Q
----
R
-
N
-------------
T
W
G
D
F
L
-
E
A
I
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
41.05
25%
-31
- C3 -
4CCO
4
NO66_HUMAN
A:
[102-256]
-----------------------------------------------------------------------------------------------------------------------------
P
A
A
A
W
S
L
Y
Q
-
A
G
----
C
S
L
R
L
-
L
C
P
-------
Q
----
A
F
S
T
T
V
W
Q
F
L
A
V
----
L
----
Q
E
Q
F
G
----
S
M
A
--
G
S
N
---
V
Y
L
T
P
P
N
-
S
Q
-
G
F
A
P
H
Y
D
D
I
E
A
F
V
L
Q
L
E
G
R
K
L
W
R
V
Y
R
P
R
---
A
P
-
T
E
E
L
-
A
---------
L
------------------------
T
----------------
C
S
P
N
F
S
Q
D
D
L
-----
G
E
P
V
L
Q
T
V
-------
L
E
P
G
D
L
-
L
Y
F
P
R
G
F
I
H
Q
A
---
E
C
----
Q
D
---
G
V
H
S
L
H
L
T
L
S
T
Y
Q
----
R
-
N
-------------
T
W
G
D
F
L
-
E
A
I
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
40.82
18%
-3
- C3 -
4GJZ
3
KDM8_HUMAN
A:
[5-235]
---------------
R
L
H
R
P
S
L
-
Q
H
F
R
E
Q
F
L
V
P
G
R
P
V
I
L
K
G
V
----
A
D
-------
H
-
W
P
C
M
Q
K
W
S
-
L
E
Y
I
Q
E
I
A
G
---
C
R
T
----
V
P
V
E
----
V
--
G
--------------------
W
-
S
Q
T
L
M
T
V
N
E
F
I
S
K
Y
I
-
V
N
EPR-
D
V
G
Y
L
-
A
Q
H
Q
L
-----
F
----
D
Q
I
P
E
L
K
Q
D
I
S
I
---------
P
D
Y
C
S
----
L
G
D
GE
E
E
E
I
T
I
N
A
W
F
G
P
Q
-
G
T
-
I
S
P
L
H
Q
D
P
Q
Q
N
F
L
V
Q
V
M
G
R
K
Y
I
R
L
Y
S
P
Q
E
S
G
A
L
-
Y
P
H
D
-
T
HLLHN----
T
------------------------
S
----------------
Q
V
D
V
E
N
-
P
D
L
E
K
-----
F
P
K
F
A
K
A
P
F
L
S
C
I
L
S
P
G
E
I
-
L
F
I
P
V
K
Y
W
H
Y
V
---
R
A
----
L
D
---
L
S
F
S
V
S
F
---
W
W
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
40.29
25%
-34
- C3 -
4DIQ
2
NO66_HUMAN
A:
[124-279]
-----------------------------------------------------------------------------------------------------------------------------
P
A
A
A
W
S
L
Y
Q
-
A
G
----
C
S
L
R
L
-
L
C
P
-------
Q
----
A
F
S
T
T
V
W
Q
F
L
A
V
----
L
----
Q
E
Q
F
G
----
S
M
A
--
G
S
N
---
V
Y
L
T
P
P
N
-
S
Q
-
G
F
A
P
H
Y
D
D
I
E
A
F
V
L
Q
L
E
G
R
K
L
W
R
V
Y
R
P
R
---
A
P
-
T
E
E
L
-
A
---------
L
------------------------
T
----------------
S
S
P
N
F
S
Q
D
D
L
-----
G
E
P
V
L
Q
T
V
-------
L
E
P
G
D
L
-
L
Y
F
P
R
G
F
I
H
Q
A
---
E
C
----
Q
D
---
G
V
H
S
L
H
L
T
L
S
T
Y
Q
----
R
-
N
-------------
T
W
G
D
F
L
-
E
A
I
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
40.13
19%
-14
- C3 -
4CSW
3
?
A:
[16-235]
----------
Q
L
P
E
T
I
L
G
G
L
A
P
-
E
E
F
L
A
N
Y
W
-
Q
K
R
P
L
L
I
R
Q
A
----
L
P
-------
G
-
F
R
--
S
P
I
T
-
P
E
E
L
A
G
L
A
C
---
E
E
G
----
V
T
A
R
----
L
--
I
---
L
E
K
--
G
--
G
A
-
Y
--
P
W-
E
V
R
Y
G
P
F
E
P
E
D
F
V
A
L
P
P
-
T
H
----
W
T
L
L
V
-
Q
E
V
-------
D
----
R
L
V
P
E
V
A
A
L
L
E
T
----
V
----
R
F
V
P
N
----
W
R
L
--
D
---
D
I
M
V
S
Y
A
P
E
-
G
G
-
T
V
G
A
H
I
D
N
Y
D
V
F
L
V
Q
A
W
G
R
R
R
W
Q
I
N
H
R
P
V
E
R
E
E
-
L
V
P
G
-
L
---------
E
----------------------------------------------------
V
-----
R
L
L
A
H
F
E
P
D
A
E
W
I
L
E
P
G
D
V
-
L
Y
L
P
P
R
I
P
H
Y
G
---
V
A
----
L
E
---
D
C
M
T
F
S
I
---
G
F
R
----
A
-
P
-------------
D
Q
A
E
L
A
-
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------