@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu40000: (2016-08-06 )
MTIDHSVTNTEQLEQQNPAIKTKLKLKKLKDQVIVITGASSGIGLVTARMAAEKGAKVVAAARNEEALKELTDELKEKGHDAIWVKADVGKEEDVNRIAETAISTFGRFDTWVNNAAVSTFGHAMDVTVEDMKRMFDTNFWGPVYGTRAAVKHYTGRGVPGALINVGSLFGDRGTVIQSTYASAKFALHGWTESIRMELEKEQAPVSVTLIHPGRIDTPYNEHAHSYLDKQPAHYRSMIYPPEAVAEAILFAAEHPKRDMYIGSQAKAIAMLGALFPRLTDRLMEKIMYHSQHAERPSNPREESALYDAGCGMHDRGTNKGWMRSRSYYTKATKRPIVSAAVVAGLVAWAAAKRCR
Atome Classification :
(27 SA)
.........10........20........30........40.......-.50........60-.....-...70........80........90........100.......110....-...120.......130.......140.......150.......160.......170........180.......190.......200...--....210.........220--------......------.-.-------230-...-----..-.-..-----.-----240..--.....250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTIDHSVT
N
T
E
Q
L
E
QQNPA
I
K
T
K
L
K
L
K
KLKD
Q
V
I
V
I
TGASSGI
G
L
V
T
A
-
R
M
A
AEKG
A
K
V
V
A
A-AR
N
E
E
-
A
L
K
E
L
T
D
E
L
K
EKGH
D
A
I
W
V
KADVG
K
E
E
D
V
N
R
I
A
E
T
A
I
S
T
FG
R
F
D
T
W
V
N
N
A
-
A
V
S
TFGHAMDV
T
V
E
D
M
K
R
M
FDTNFWGPVYG
T
R
A
A
V
K
HYTGRGVP
G
A
L
I
N
V
G
S
LFG-DRG
T
V
I
Q
STYAS
A
K
F
A
LHGW
T
E
S
I
R
M
E
L
EKEQA
P
--
V
S
V
T
L
--IHPGRIDT
P
Y
-
N
--------
E
H
A
H
S
Y
------
L
-D-------K---QPA-----
H
Y
-R-SM-----I-----Y
P
P
E
A
--
V
A
E
A
I
L
F
AAEHPKRDMYIGS
Q
A
K
A
I
A
M
L
G
A
L
F
P
R
L
T
D
R
L
M
E
K
I
M
Y
H
S
Q
HAERPSNPREESALYDAGCGMHDRGTNKG
W
M
RSR
S
Y
YTKATKRP
I
V
S
A
A
V
V
A
G
L
V
A
W
A
A
AKRCR
50
PsiBlast_CBE
85.64
34%
-99
- C2 -
2JAP
2
?
C:
[5-231]
----------------------------
L
Q
G
K
V
A
L
I
T
G
A
S
S
G
I
G
E
A
T
A
-
R
A
L
A
A
E
G
A
A
V
A
I
A
-
A
R
R
V
E
-
K
L
R
A
L
G
D
E
L
T
A
A
G
A
K
V
H
V
L
E
L
D
V
A
D
R
Q
G
V
D
A
A
V
A
S
T
V
E
A
L
G
G
L
D
I
L
V
N
N
A
-
G
I
M
L
L
G
P
V
E
D
A
D
T
T
D
W
T
R
M
I
D
T
N
L
L
G
L
M
Y
M
T
R
A
A
L
P
H
L
L
R
S
--
K
G
T
V
V
Q
M
S
S
I
A
G
-
R
V
N
V
R
N
A
A
V
Y
Q
A
T
K
F
G
V
N
A
F
S
E
T
L
R
Q
E
V
T
E
R
--
G
--
V
R
V
V
V
--
I
E
P
G
T
T
D
T
E
L
-
R
--------
G
H
I
T
H
T
------
A
-
T
-------
K
---
E
M
Y
-----
E
Q
-
R
I
S
Q
-----
I
-----
R
K
L
Q
A
QD
I
A
E
A
V
R
Y
A
V
T
A
P
----------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
85.57
34%
-98
- C2 -
2JAP
2
?
D:
[5-231]
----------------------------
L
Q
G
K
V
A
L
I
T
G
A
S
S
G
I
G
E
A
T
A
-
R
A
L
A
A
E
G
A
A
V
A
I
A
-
A
R
R
V
E
-
K
L
R
A
L
G
D
E
L
T
A
A
G
A
K
V
H
V
L
E
L
D
V
A
D
R
Q
G
V
D
A
A
V
A
S
T
V
E
A
L
G
G
L
D
I
L
V
N
N
A
-
G
I
M
L
L
G
P
V
E
D
A
D
T
T
D
W
T
R
M
I
D
T
N
L
L
G
L
M
Y
M
T
R
A
A
L
P
H
L
L
R
S
--
K
G
T
V
V
Q
M
S
S
I
A
G
-
R
V
N
V
R
N
A
A
V
Y
Q
A
T
K
F
G
V
N
A
F
S
E
T
L
R
Q
E
V
T
E
R
--
G
--
V
R
V
V
V
--
I
E
P
G
T
T
D
T
E
L
-
R
--------
G
H
I
T
H
T
------
A
-
T
-------
K
---
E
M
Y
-----
E
Q
-
R
I
S
Q
-----
I
-----
R
K
L
Q
A
QD
I
A
E
A
V
R
Y
A
V
T
A
P
----------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
85.37
34%
-98
- C2 -
2JAP
2
?
B:
[5-231]
----------------------------
L
Q
G
K
V
A
L
I
T
G
A
S
S
G
I
G
E
A
T
A
-
R
A
L
A
A
E
G
A
A
V
A
I
A
-
A
R
R
V
E
-
K
L
R
A
L
G
D
E
L
T
A
A
G
A
K
V
H
V
L
E
L
D
V
A
D
R
Q
G
V
D
A
A
V
A
S
T
V
E
A
L
G
G
L
D
I
L
V
N
N
A
-
G
I
M
L
L
G
P
V
E
D
A
D
T
T
D
W
T
R
M
I
D
T
N
L
L
G
L
M
Y
M
T
R
A
A
L
P
H
L
L
R
S
--
K
G
T
V
V
Q
M
S
S
I
A
G
-
R
V
N
V
R
N
A
A
V
Y
Q
A
T
K
F
G
V
N
A
F
S
E
T
L
R
Q
E
V
T
E
R
--
G
--
V
R
V
V
V
--
I
E
P
G
T
T
D
T
E
L
-
R
--------
G
H
I
T
H
T
------
A
-
T
-------
K
---
E
M
Y
-----
E
Q
-
R
I
S
Q
-----
I
-----
R
K
L
Q
A
Q
D
I
A
E
A
V
R
Y
A
V
T
A
P
----------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
85.36
34%
-97
- C2 -
2JAP
2
?
A:
[5-231]
----------------------------
L
Q
G
K
V
A
L
I
T
G
A
S
S
G
I
G
E
A
T
A
-
R
A
L
A
A
E
G
A
A
V
A
I
A
-
A
R
R
V
E
-
K
L
R
A
L
G
D
E
L
T
A
A
G
A
K
V
H
V
L
E
L
D
V
A
D
R
Q
G
V
D
A
A
V
A
S
T
V
E
A
L
G
G
L
D
I
L
V
N
N
A
-
G
I
M
L
L
G
P
V
E
D
A
D
T
T
D
W
T
R
M
I
D
T
N
L
L
G
L
M
Y
M
T
R
A
A
L
P
H
L
L
R
S
--
K
G
T
V
V
Q
M
S
S
I
A
G
-
R
V
N
V
R
N
A
A
V
Y
Q
A
T
K
F
G
V
N
A
F
S
E
T
L
R
Q
E
V
T
E
R
--
G
--
V
R
V
V
V
--
I
E
P
G
T
T
D
T
E
L
-
R
--------
G
H
I
T
H
T
------
A
-
T
-------
K
---
E
M
Y
-----
E
Q
-
R
I
S
Q
-----
I
-----
R
K
L
Q
A
Q
D
I
A
E
A
V
R
Y
A
V
T
A
P
----------------------------------------------------------------------------------------------------
98
HHSearch
83.82
29%
-83
- C2 -
3WDS
2
?
A:
[7-245]
-------------------------
I
F
D
L
S
G
R
K
A
I
V
T
G
G
S
K
G
I
G
A
A
I
A
-
R
A
L
D
K
A
G
A
T
V
A
I
A
-
D
L
D
V
M
-
A
A
Q
A
V
V
A
G
L
E
---
N
G
G
F
A
V
E
V
D
V
T
K
R
A
S
V
D
A
A
M
Q
K
A
I
D
A
L
G
G
F
D
L
L
C
A
N
A
-
G
V
S
T
M
R
P
A
V
D
I
T
D
E
E
W
D
F
N
F
D
V
N
A
R
G
V
F
L
A
N
Q
I
A
C
R
H
F
L
A
S
N
T
K
G
V
I
V
N
T
A
S
L
A
A
-
K
V
G
A
P
L
L
A
H
Y
S
A
S
K
F
A
V
F
G
W
T
Q
A
L
A
R
E
M
A
--
P
K
N
--
I
R
V
N
C
--
V
C
P
G
F
V
K
T
A
M
-
Q
--------
E
R
E
I
I
W
E
A
E
L
R
G
M
T
P
E
A
V
R
A
E
Y
V
---
S
L
T
-----
P
L
---
G
R
-----
I
-----
E
E
P
E
D
--
V
A
D
V
V
V
F
L
A
S
D
A
----------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
83.41
31%
-88
- C2 -
3WYE
1
BUDC_CORGT (first)
A:
[3-244]
-------------------------------
K
V
A
L
V
T
G
A
G
Q
G
I
G
K
A
I
A
-
L
R
L
V
K
D
G
F
A
V
A
I
A
-
D
Y
N
D
A
-
T
A
K
A
V
A
S
E
I
N
Q
A
G
G
H
A
V
A
V
K
V
D
V
S
D
R
D
Q
V
F
A
A
V
E
Q
A
R
K
T
L
G
G
F
D
V
I
V
N
N
A
-
G
I
A
Q
I
K
P
L
L
E
V
T
E
E
D
L
K
Q
I
Y
S
V
N
V
F
S
V
F
F
G
I
Q
A
A
V
E
A
F
K
K
E
G
H
G
G
K
I
I
N
A
A
S
I
A
A
-
I
Q
G
F
P
I
L
S
A
Y
S
T
T
K
F
A
V
R
G
L
T
Q
T
A
A
R
D
L
----
A
P
--
L
G
I
T
V
N
G
Y
C
P
G
I
V
G
T
G
M
-
W
--------
E
Q
I
D
A
E
------
L
-
S
-------
K
I
NG
K
P
I
G
E
N
F
K
E
Y
-
S
-
S
S
-----
I
ALG
R
P
S
V
P
E
D
--
V
A
G
L
V
S
F
L
A
-
S
P
D
S
D
Y
M
T
G
---------------------------------------------------------------------------------------------
73
PsiBlast_CBE
80.68
31%
-94
- C2 -
3WYE
1
BUDC_CORGT (first)
B:
[3-244]
-------------------------------
K
V
A
L
V
T
G
A
G
Q
G
I
G
K
A
I
A
-
L
R
L
V
K
D
G
F
A
V
A
I
A
-
D
Y
N
D
A
-
T
A
K
A
V
A
S
E
I
N
Q
A
G
G
H
A
V
A
V
K
V
D
V
S
D
R
D
Q
V
F
A
A
V
E
Q
A
R
K
T
L
G
G
F
D
V
I
V
N
N
A
-
G
I
A
Q
I
K
P
L
L
E
V
T
E
E
D
L
K
Q
I
Y
S
V
N
V
F
S
V
F
F
G
I
Q
A
A
V
E
A
F
K
K
E
G
H
G
G
K
I
I
N
A
A
S
I
A
A
-
I
Q
G
F
P
I
L
S
A
Y
S
T
T
K
F
A
V
R
G
L
T
Q
T
A
A
R
D
L
----
A
P
--
L
G
I
T
V
N
G
Y
C
P
G
I
V
G
T
G
M
-
W
--------
E
Q
I
D
A
E
------
L
-
S
-------
K
-----------------
S
-----
I
ALG
R
P
S
V
P
E
D
--
V
A
G
L
V
S
F
L
A
-
S
P
D
S
D
Y
M
T
G
---------------------------------------------------------------------------------------------
23
PsiBlast_CBE
80.01
32%
-79
- C2 -
4NBU
2
?
B:
[8-232]
-------------------------
M
S
R
L
Q
D
K
V
A
I
I
T
G
A
A
N
G
I
G
L
E
A
A
-
R
V
F
M
K
E
G
A
K
V
V
I
A
-
D
F
N
E
A
-
A
G
K
E
A
V
----
E
A
N
P
G
V
V
F
I
R
V
D
V
S
D
R
E
S
V
H
R
L
V
E
N
V
A
E
R
F
G
K
I
D
I
L
I
N
N
A
-
G
I
T
R
D
S
M
L
S
K
M
T
V
D
Q
F
Q
Q
V
I
N
V
N
L
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
A
E
Q
G
-
K
G
K
I
I
N
T
S
S
V
T
G
-
T
Y
G
N
V
G
Q
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
L
A
R
K
--
G
--
I
N
V
N
A
--
V
A
P
G
F
T
E
T
A
M
V
A
--------
E
V
P
E
K
V
------
I
-
E
-------
K
---
M
K
A
-----
Q
V
P
M
-
G
R
-----
L
-----
G
K
P
E
D
--
I
A
N
A
Y
L
F
L
A
S
H
-----------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
79.92
34%
-118
- C2 -
2EHD
1
?
B:
[8-218]
---------------------------------
V
L
I
T
G
A
S
R
G
I
G
E
A
T
A
-
R
L
L
H
A
K
G
Y
R
V
G
L
M
-
A
R
D
E
K
-
R
L
Q
A
L
A
A
E
L
E
----
G
A
L
P
L
P
G
D
V
R
E
E
G
D
W
A
R
A
V
A
A
M
E
E
A
F
G
E
L
S
A
L
V
N
N
A
-
G
V
G
V
M
K
P
V
H
E
L
T
L
E
E
W
R
L
V
L
D
T
N
L
T
G
A
F
L
G
I
R
H
A
V
P
A
L
L
R
R
G
-
G
G
T
I
V
N
V
G
S
L
A
G
-
K
N
P
F
K
G
G
A
A
Y
N
A
S
K
F
G
L
L
G
L
A
G
A
A
M
L
D
L
--
R
E
A
N
--
V
R
V
V
N
--
V
L
P
G
S
V
-----------------------------------------------------
K
L
------------
K
P
E
D
--
V
A
Q
A
V
L
F
A
L
E
M
P
G
H
A
M
------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
78.12
32%
-58
- C2 -
3TOX
1
?
E:
[4-235]
--------------------------
S
R
L
E
G
K
I
A
I
V
T
G
A
S
S
G
I
G
R
A
A
A
-
L
L
F
A
R
E
G
A
K
V
V
V
T
-
A
R
N
G
N
-
A
L
A
E
L
T
D
E
I
A
G
G
G
G
E
A
A
A
L
A
G
D
V
G
D
E
A
L
H
E
A
L
V
E
L
A
V
R
R
F
G
G
L
D
T
A
F
N
N
A
G
A
L
G
A
M
G
E
I
S
S
L
S
V
E
G
W
R
E
T
L
D
T
N
L
T
S
A
F
L
A
A
K
Y
Q
V
P
A
I
A
A
L
G
-
G
G
S
L
T
F
T
S
S
F
V
G
H
T
A
G
F
A
G
V
A
P
Y
A
A
S
K
A
G
L
I
G
L
V
Q
A
L
A
V
E
L
G
A
R
G
----
I
R
V
N
A
--
L
L
P
G
G
T
D
T
P
A
-
N
FANLPGAA
P
E
T
R
G
F
------
V
-
E
-------
G
---
L
H
A
-----
L
K
-
R
--------
I
-----
A
R
P
E
E
--
I
A
E
A
A
L
Y
L
A
-------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
77.76
32%
-82
- C2 -
4NBU
1
?
C:
[9-232]
--------------------------
S
R
L
Q
D
K
V
A
I
I
T
G
A
A
N
G
I
G
L
E
A
A
-
R
V
F
M
K
E
G
A
K
V
V
I
A
-
D
F
N
E
A
-
A
G
K
E
A
V
----
E
A
N
P
G
V
V
F
I
R
V
D
V
S
D
R
E
S
V
H
R
L
V
E
N
V
A
E
R
F
G
K
I
D
I
L
I
N
N
A
-
G
I
T
R
D
S
M
L
S
K
M
T
V
D
Q
F
Q
Q
V
I
N
V
N
L
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
A
E
Q
G
-
K
G
K
I
I
N
T
S
S
V
T
G
-
T
Y
G
N
V
G
Q
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
L
A
R
K
--
G
--
I
N
V
N
A
--
V
A
P
G
F
T
E
T
A
M
V
A
--------
E
V
P
E
K
V
------
I
-
E
-------
K
---
M
K
A
-----
Q
V
P
M
-
G
R
-----
L
-----
G
K
P
E
D
--
I
A
N
A
Y
L
F
L
A
S
H
-----------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
77.63
32%
-81
- C2 -
4NBU
1
?
A:
[9-232]
--------------------------
S
R
L
Q
D
K
V
A
I
I
T
G
A
A
N
G
I
G
L
E
A
A
-
R
V
F
M
K
E
G
A
K
V
V
I
A
-
D
F
N
E
A
-
A
G
K
E
A
V
----
E
A
N
P
G
V
V
F
I
R
V
D
V
S
D
R
E
S
V
H
R
L
V
E
N
V
A
E
R
F
G
K
I
D
I
L
I
N
N
A
-
G
I
T
R
D
S
M
L
S
K
M
T
V
D
Q
F
Q
Q
V
I
N
V
N
L
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
A
E
Q
G
-
K
G
K
I
I
N
T
S
S
V
T
G
-
T
Y
G
N
V
G
Q
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
L
A
R
K
--
G
--
I
N
V
N
A
--
V
A
P
G
F
T
E
T
A
M
V
A
--------
E
V
P
E
K
V
------
I
-
E
-------
K
---
M
K
A
-----
Q
V
P
M
-
G
R
-----
L
-----
G
K
P
E
D
--
I
A
N
A
Y
L
F
L
A
S
H
-----------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
77.56
32%
-58
- C2 -
3TOX
1
?
G:
[4-235]
--------------------------
S
R
L
E
G
K
I
A
I
V
T
G
A
S
S
G
I
G
R
A
A
A
-
L
L
F
A
R
E
G
A
K
V
V
V
T
-
A
R
N
G
N
-
A
L
A
E
L
T
D
E
I
A
G
G
G
G
E
A
A
A
L
A
G
D
V
G
D
E
A
L
H
E
A
L
V
E
L
A
V
R
R
F
G
G
L
D
T
A
F
N
N
A
G
A
L
G
A
M
G
E
I
S
S
L
S
V
E
G
W
R
E
T
L
D
T
N
L
T
S
A
F
L
A
A
K
Y
Q
V
P
A
I
A
A
L
G
-
G
G
S
L
T
F
T
S
S
F
V
G
H
T
A
G
F
A
G
V
A
P
Y
A
A
S
K
A
G
L
I
G
L
V
Q
A
L
A
V
E
L
G
A
R
G
----
I
R
V
N
A
--
L
L
P
G
G
T
D
T
P
A
-
N
FANLA---
P
E
T
R
G
F
------
V
-
E
-------
G
---
L
H
A
-----
L
K
-
R
--------
I
-----
A
R
P
E
E
--
I
A
E
A
A
L
Y
L
A
-------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
77.38
32%
-60
- C2 -
3TOX
1
?
I:
[4-235]
--------------------------
S
R
L
E
G
K
I
A
I
V
T
G
A
S
S
G
I
G
R
A
A
A
-
L
L
F
A
R
E
G
A
K
V
V
V
T
-
A
R
N
G
N
-
A
L
A
E
L
T
D
E
I
A
G
G
G
G
E
A
A
A
L
A
G
D
V
G
D
E
A
L
H
E
A
L
V
E
L
A
V
R
R
F
G
G
L
D
T
A
F
N
N
A
G
A
L
G
A
M
G
E
I
S
S
L
S
V
E
G
W
R
E
T
L
D
T
N
L
T
S
A
F
L
A
A
K
Y
Q
V
P
A
I
A
A
L
G
-
G
G
S
L
T
F
T
S
S
F
V
G
H
T
A
G
F
A
G
V
A
P
Y
A
A
S
K
A
G
L
I
G
L
V
Q
A
L
A
V
E
L
G
A
R
G
----
I
R
V
N
A
--
L
L
P
G
G
T
D
T
P
A
-
N
FANLPGAA
P
E
T
R
G
F
------
V
-
E
-------
G
---
L
H
A
-----
L
K
-
R
--------
I
-----
A
R
P
E
E
--
I
A
E
A
A
L
Y
L
A
-------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
77.16
32%
-60
- C2 -
3TOX
1
?
C:
[4-235]
--------------------------
S
R
L
E
G
K
I
A
I
V
T
G
A
S
S
G
I
G
R
A
A
A
-
L
L
F
A
R
E
G
A
K
V
V
V
T
-
A
R
N
G
N
-
A
L
A
E
L
T
D
E
I
A
G
G
G
G
E
A
A
A
L
A
G
D
V
G
D
E
A
L
H
E
A
L
V
E
L
A
V
R
R
F
G
G
L
D
T
A
F
N
N
A
G
A
L
G
A
M
G
E
I
S
S
L
S
V
E
G
W
R
E
T
L
D
T
N
L
T
S
A
F
L
A
A
K
Y
Q
V
P
A
I
A
A
L
G
-
G
G
S
L
T
F
T
S
S
F
V
G
H
T
A
G
F
A
G
V
A
P
Y
A
A
S
K
A
G
L
I
G
L
V
Q
A
L
A
V
E
L
G
A
R
G
----
I
R
V
N
A
--
L
L
P
G
G
T
D
T
P
A
-
N
FANLPGAA
P
E
T
R
G
F
------
V
-
E
-------
G
---
L
H
A
-----
L
K
-
R
--------
I
-----
A
R
P
E
E
--
I
A
E
A
A
L
Y
L
A
-------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
77.04
36%
0
- C- -
4MOW
1
?
B:
[9-205]
-------------------------
M
S
K
L
A
G
K
V
A
I
V
T
G
A
S
K
G
I
G
A
A
I
A
-
K
A
L
A
D
E
G
A
A
V
V
V
N
Y
A
S
S
K
A
-
G
A
D
A
V
V
S
A
I
T
E
A
G
G
R
A
V
A
V
G
G
D
V
S
K
A
A
D
A
Q
R
I
V
D
T
A
I
E
T
Y
G
R
L
D
V
L
V
N
N
S
-
G
V
Y
E
F
A
P
I
E
A
I
T
E
E
H
Y
R
R
Q
F
D
T
N
V
F
G
V
L
L
T
T
Q
A
A
V
K
H
L
-
G
E
G
A
--
S
I
I
N
I
S
S
V
V
T
-
S
I
T
P
P
A
S
A
V
Y
S
G
T
K
G
A
V
D
A
I
T
G
V
L
A
L
E
L
G
P
R
K
----
I
R
V
N
A
--
I
N
P
G
M
I
V
T
------------
E
G
T
H
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
76.72
32%
-81
- C2 -
4NBU
2
?
D:
[9-232]
--------------------------
S
R
L
Q
D
K
V
A
I
I
T
G
A
A
N
G
I
G
L
E
A
A
-
R
V
F
M
K
E
G
A
K
V
V
I
A
-
D
F
N
E
A
-
A
G
K
E
A
V
----
E
A
N
P
G
V
V
F
I
R
V
D
V
S
D
R
E
S
V
H
R
L
V
E
N
V
A
E
R
F
G
K
I
D
I
L
I
N
N
A
-
G
I
T
R
D
S
M
L
S
K
M
T
V
D
Q
F
Q
Q
V
I
N
V
N
L
T
G
V
F
H
C
T
Q
A
V
L
P
Y
M
A
E
Q
G
-
K
G
K
I
I
N
T
S
S
V
T
G
-
T
Y
G
N
V
G
Q
T
N
Y
A
A
A
K
A
G
V
I
G
M
T
K
T
W
A
K
E
L
A
R
K
--
G
--
I
N
V
N
A
--
V
A
P
G
F
T
E
T
A
M
V
A
--------
E
V
P
E
K
V
------
I
-
E
-------
K
---
M
K
A
-----
Q
V
P
M
-
G
R
-----
L
-----
G
K
P
E
D
--
I
A
N
A
Y
L
F
L
A
S
H
-----------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
76.69
32%
-58
- C2 -
3TOX
1
?
D:
[4-235]
--------------------------
S
R
L
E
G
K
I
A
I
V
T
G
A
S
S
G
I
G
R
A
A
A
-
L
L
F
A
R
E
G
A
K
V
V
V
T
-
A
R
N
G
N
-
A
L
A
E
L
T
D
E
I
A
G
G
G
G
E
A
A
A
L
A
G
D
V
G
D
E
A
L
H
E
A
L
V
E
L
A
V
R
R
F
G
G
L
D
T
A
F
N
N
A
G
A
L
G
A
M
G
E
I
S
S
L
S
V
E
G
W
R
E
T
L
D
T
N
L
T
S
A
F
L
A
A
K
Y
Q
V
P
A
I
A
A
L
G
-
G
G
S
L
T
F
T
S
S
F
V
G
H
T
A
G
F
A
G
V
A
P
Y
A
A
S
K
A
G
L
I
G
L
V
Q
A
L
A
V
E
L
G
A
R
G
----
I
R
V
N
A
--
L
L
P
G
G
T
D
T
P
A
-
N
FANLPGAA
P
E
T
R
G
F
------
V
-
E
-------
G
---
L
H
A
-----
L
K
-
R
--------
I
-----
A
R
P
E
E
--
I
A
E
A
A
L
Y
L
A
-------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
76.55
32%
-62
- C2 -
3TOX
1
?
A:
[4-235]
--------------------------
S
R
L
E
G
K
I
A
I
V
T
G
A
S
S
G
I
G
R
A
A
A
-
L
L
F
A
R
E
G
A
K
V
V
V
T
-
A
R
N
G
N
-
A
L
A
E
L
T
D
E
I
A
G
G
G
G
E
A
A
A
L
A
G
D
V
G
D
E
A
L
H
E
A
L
V
E
L
A
V
R
R
F
G
G
L
D
T
A
F
N
N
A
G
A
L
G
A
M
G
E
I
S
S
L
S
V
E
G
W
R
E
T
L
D
T
N
L
T
S
A
F
L
A
A
K
Y
Q
V
P
A
I
A
A
L
G
-
G
G
S
L
T
F
T
S
S
F
V
G
H
T
A
G
F
A
G
V
A
P
Y
A
A
S
K
A
G
L
I
G
L
V
Q
A
L
A
V
E
L
G
A
R
G
----
I
R
V
N
A
--
L
L
P
G
G
T
D
T
P
A
-
N
FANLPGAA
P
E
T
R
G
F
------
V
-
E
-------
G
---
L
H
A
-----
L
K
-
R
--------
I
-----
A
R
P
E
E
--
I
A
E
A
A
L
Y
L
A
-------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
76.38
34%
-110
- C2 -
2EHD
1
?
A:
[8-218]
---------------------------------
V
L
I
T
G
A
S
R
G
I
G
E
A
T
A
-
R
L
L
H
A
K
G
Y
R
V
G
L
M
-
A
R
D
E
K
-
R
L
Q
A
L
A
A
E
L
E
----
G
A
L
P
L
P
G
D
V
R
E
E
G
D
W
A
R
A
V
A
A
M
E
E
A
F
G
E
L
S
A
L
V
N
N
A
-
G
V
G
V
M
K
P
V
H
E
L
T
L
E
E
W
R
L
V
L
D
T
N
L
T
G
A
F
L
G
I
R
H
A
V
P
A
L
L
R
R
G
-
G
G
T
I
V
N
V
G
S
L
A
G
-
K
N
P
F
K
G
G
A
A
Y
N
A
S
K
F
G
L
L
G
L
A
G
A
A
M
L
D
L
--
R
E
A
N
--
V
R
V
V
N
--
V
L
P
G
--------------------------------------------------------
L
------------
K
P
E
D
--
V
A
Q
A
V
L
F
A
L
E
M
P
G
H
A
M
------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
75.18
34%
-16
- C2 -
3AY6
2
DHG4_BACME
C:
[13-240]
----------------------------
L
K
D
K
V
V
V
I
T
G
G
S
T
G
L
G
R
A
M
A
V
R
F
G
Q
E
E
A
K
V
V
I
N
Y
-
Y
N
N
E
E
-
E
A
L
D
A
K
K
E
V
E
E
A
G
G
Q
A
I
I
V
Q
G
D
V
T
K
E
E
D
V
V
N
L
V
Q
T
A
I
K
E
F
G
T
L
D
V
M
I
N
N
A
-
G
V
E
N
P
V
P
S
H
E
L
S
L
D
N
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
D
I
K
G
N
V
I
N
M
S
S
V
H
E
-
M
I
P
W
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
----
A
P
KG
I
R
V
N
N
--
I
G
P
G
A
M
N
T
P
I
-
N
----------
A
E
K
F
------
A
-
D
-------
P
V
--
Q
R
A
-----
D
V
-
E
-
S
M
IPMGY
I
-----
G
K
P
E
E
--
V
A
A
V
A
A
F
L
A
-------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
74.85
34%
-14
- C2 -
3AY6
2
DHG4_BACME
A:
[13-240]
----------------------------
L
K
D
K
V
V
V
I
T
G
G
S
T
G
L
G
R
A
M
A
V
R
F
G
Q
E
E
A
K
V
V
I
N
Y
-
Y
N
N
E
E
-
E
A
L
D
A
K
K
E
V
E
E
A
G
G
Q
A
I
I
V
Q
G
D
V
T
K
E
E
D
V
V
N
L
V
Q
T
A
I
K
E
F
G
T
L
D
V
M
I
N
N
A
-
G
V
E
N
P
V
P
S
H
E
L
S
L
D
N
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
D
I
K
G
N
V
I
N
M
S
S
V
H
E
-
M
I
P
W
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
----
A
P
KG
I
R
V
N
N
--
I
G
P
G
A
M
N
T
P
I
-
N
----------
A
E
K
F
------
A
-
D
-------
P
V
--
Q
R
A
-----
D
V
-
E
-
S
M
IPMGY
I
-----
G
K
P
E
E
--
V
A
A
V
A
A
F
L
A
-------------------------------------------------------------------------------------------------------
92
HHSearch
74.45
31%
-18
* C2 *
1GEE
1
DHG_BACME
A:
[3-235]
--------------------------
K
D
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
-
I
R
F
A
T
E
K
A
K
V
V
V
N
-
Y
R
S
K
E
D
E
A
N
S
V
L
E
E
I
K
K
V
G
G
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
-
G
L
E
N
P
V
S
S
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
D
I
K
G
T
V
I
N
M
S
S
V
H
E
-
K
I
P
W
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
--
P
K
G
--
I
R
V
N
N
--
I
G
P
G
A
I
N
T
P
I
-
N
--------
A
E
K
F
A
D
------
P
-
E
Q
R
A
D
V
--
E
---
S
M
I
-----
P
M
---
G
Y
-----
I
-----
G
E
P
E
E
--
I
A
A
V
A
A
W
L
A
S
S
E
----------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
73.61
34%
-13
- C2 -
3AY6
2
DHG4_BACME
B:
[13-240]
----------------------------
L
K
D
K
V
V
V
I
T
G
G
S
T
G
L
G
R
A
M
A
V
R
F
G
Q
E
E
A
K
V
V
I
N
Y
-
Y
N
N
E
E
-
E
A
L
D
A
K
K
E
V
E
E
A
G
G
Q
A
I
I
V
Q
G
D
V
T
K
E
E
D
V
V
N
L
V
Q
T
A
I
K
E
F
G
T
L
D
V
M
I
N
N
A
-
G
V
E
N
P
V
P
S
H
E
L
S
L
D
N
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
D
I
K
G
N
V
I
N
M
S
S
V
H
E
-
M
I
P
W
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
----
A
P
KG
I
R
V
N
N
--
I
G
P
G
A
M
N
T
P
I
-
N
----------
A
E
K
F
------
A
-
D
-------
P
V
--
Q
R
A
-----
D
V
-
E
-
S
M
IPMGY
I
-----
G
K
P
E
E
--
V
A
A
V
A
A
F
L
A
-------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
72.05
34%
-13
- C2 -
3AY6
2
DHG4_BACME
D:
[13-240]
----------------------------
L
K
D
K
V
V
V
I
T
G
G
S
T
G
L
G
R
A
M
A
V
R
F
G
Q
E
E
A
K
V
V
I
N
Y
-
Y
N
N
E
E
-
E
A
L
D
A
K
K
E
V
E
E
A
G
G
Q
A
I
I
V
Q
G
D
V
T
K
E
E
D
V
V
N
L
V
Q
T
A
I
K
E
F
G
T
L
D
V
M
I
N
N
A
-
G
V
E
N
P
V
P
S
H
E
L
S
L
D
N
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
D
I
K
G
N
V
I
N
M
S
S
V
H
E
-
M
I
P
W
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
----
A
P
KG
I
R
V
N
N
--
I
G
P
G
A
M
N
T
P
I
-
N
----------
A
E
K
F
------
A
-
D
-------
P
V--
Q
R
A
-----
D
V
-
E
-
S
M
IPMGY
I
-----
G
K
P
E
E
--
V
A
A
V
A
A
F
L
A
-------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
68.26
34%
-13
- C2 -
1GCO
1
DHG_BACME
E:
[3-213]
--------------------------
K
D
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
N
Y
-
R
S
K
E
D
-
E
A
N
S
V
L
E
E
I
K
K
V
G
G
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
-
G
L
E
N
P
V
S
S
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
D
I
K
G
T
V
I
N
M
S
S
V
H
E
-
K
I
P
W
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
----
A
P
KG
I
R
V
N
N
--
I
G
P
G
A
I
N
T
P
I
-
N
----------
A
E
K
F
------
A
-
D
P------
E
---
Q
R
A
-----
D
V
-
E
-
S
M
-----
I
----------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
67.58
34%
-12
- C2 -
1GCO
1
DHG_BACME
B:
[3-213]
--------------------------
K
D
L
E
G
K
V
V
V
I
T
G
S
S
T
G
L
G
K
S
M
A
I
R
F
A
T
E
K
A
K
V
V
V
N
Y
-
R
S
K
E
D
-
E
A
N
S
V
L
E
E
I
K
K
V
G
G
E
A
I
A
V
K
G
D
V
T
V
E
S
D
V
I
N
L
V
Q
S
A
I
K
E
F
G
K
L
D
V
M
I
N
N
A
-
G
L
E
N
P
V
S
S
H
E
M
S
L
S
D
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
D
I
K
G
T
V
I
N
M
S
S
V
H
E
-
K
I
P
W
P
L
F
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
----
A
P
KG
I
R
V
N
N
--
I
G
P
G
A
I
N
T
P
I
-
N
----------
A
E
K
F
------
A
-
D
P------
E
---
Q
R
A
-----
D
V
-
E
-
S
M
-----
I
----------------------------------------------------------------------------------------------------------------------------